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Category Archives: Transhuman News
Scientists Say Space Is Filled With Invisible Walls – Futurism
Posted: May 17, 2022 at 7:47 pm
Scientists current best theories about the arrangement of the cosmos suggest that small galaxies should be distributed around their host galaxies in seemingly random orbits.
But observations have found that these smaller galaxies arrange themselves in thin disks around their hosts, Vice reports, not unlike Saturns rings. Needless to say, that represents a puzzling gap between knowledge and theory.
Researchers are now trying to reconcile this gap by suggesting smaller galaxies may be conforming to invisible walls created by a new class of particles called symmetrons a fascinating proposal that could rewrite the laws of astrophysics.
The standard theory, known as the Lambda cold dark matter (Lambda-CDM) model suggests that the universe is made up of three key elements: the cosmological constant, which is a coefficient added by Einstein to explain his equations of general relativity, cold dark matter which are slow moving theoretical particles that dont emit radiation, and the conventional matter we interact with every day.
That theory suggests that smaller galaxies should be captured by the gravitational pull of larger host galaxies and forced into chaotic orbits, something that has not been reflected in real world observations.
Now, two researchers from the University of Nottingham may have come up with an explanation, as detailed in a new, yet-to-be-peer-reviewed study.
They suggest a fifth force could be arranging the galaxies into disk shapes, while still considering the existence of dark matter, the mysterious substance that appears to make up the vast majority of the universes mass.
According to their theory, speculative particles known as symmetrons, which researchers have used to explain gaps in our knowledge of the cosmos, could generate this force to form domain walls, or boundaries in space.
We know that we need new particles because we have dark matter and dark energy and so we suspect that were going to need to add new particles to our standard model to account for those things, Aneesh Naik, a research fellow at the University of Nottingham, and lead author of the preprint, told Vice.
Thats the context in which people study theories like symmetron theory its a new particle candidate for dark energy and/or dark matter, he added.
These particles could exist in groups of different polar states, forming invisible walls between them. These walls, in turn, could trigger smaller galaxies to form disks around much bigger host galaxies.
But many questions remain, and Naik and his colleague University of Nottingham physicist Clare Burrage have plenty of work ahead of them to solidify the theory.
READ MORE: Space Has Invisible Walls Created by Mysterious Symmetrons, Scientists Propose [Vice]
More on dark matter: Scientist Says Dark Matter Could Likely Be Incredible Fuel for Spacecraft
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Team Claims to Have Found Chunk of Asteroid That Killed the Dinosaurs – Futurism
Posted: at 7:47 pm
They also found an impaled turtle and fish full of debris.Die Hard
Scientists say theyve figured out what happened the day an apocalyptic asteroid crashed into Earth and annihilated the dinosaurs.
Naturalist Sir David Attenborough and paleontologist Robert DePalma filmed a documentary about the 66-million-year old rock fragment they found in North Dakota.The film, Dinosaur Apocalypse, debuts on PBSthis week, but yesterdays CNN report on the pair explains where the fragment was located and how its related to the dino wipeout.
According to CNN, tiny pieces of amber that contain vaporized asteroid dust are from the Hell Creek Formation in the Western United States, which they believe preserved part of the deadly day due its proximity to the impact site. Fossils from the area include fish with gills full of toxic debris, a turtle impaled on a stick, and a dino leg that was possibly blown off its owner.
It gives a moment by moment story of what happens right after impact and you end up getting such a rich resource for scientific investigation, DePalma told the news outlet. In that amber weve located a number of spherules that were basically frozen in time. Theyre perfectly preserved.
The site is 2,000 miles away from the purported asteroid crater located off the coast of Mexico, which means its just far enough that the Hell Creek animals may have died on the day the asteroid struck.
Although the findings have yet to be published in a peer-reviewed journal, CNN reported that Michael Benton, a professor of vertebrate paleontology at the University of Bristol, worked as scientific adviser on the film and thinks the conclusions are accurate.
Its grim thought to imagine the last day for the dinos. But as the work holds up to scrutiny, it would help to understand what happened to untold species, forever changing the course of natural history.
More on sudden changes: Watch an Entire House Suddenly Fall Into the Ocean
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Team Claims to Have Found Chunk of Asteroid That Killed the Dinosaurs - Futurism
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It’s Surprisingly Likely That You Have a Nasty Parasite in Your Eyeball – Futurism
Posted: at 7:47 pm
They say the eyes are the windows to the soul.
And now, scientists say, it turns out they might also be windows toone of the worlds preeminent parasites.
In an essay for The Conversation, researchers described how they were able to detect infection from the Toxoplasma gondii parasite by studying thousands of retinal photographs, searching for signs of the sometimes eye-attacking disease.
Toxoplasmosis has, in recent years, gained a somewhat memetic reputation because its main carriers are cats and its primary transmission vector is, well, cat poop. Studies conducted over the last few decades have associated toxoplasmosis with everything from changes in sexual proclivities to higher rates of car accidents, and Futurism recently spoke to one of the authors of a study that found a correlation between childhood cat ownership and psychosis in adulthood.
As it turns out, toxoplasmosis is extremely common. The latest research suggests that anywhere between 30 and 50 percent of the global population is infected, and as Justine Smith and Joo Furtado recount in their essay for The Conversation, that percentage may be as high as 66 percent per a recent community-based study.
The parasite which, it should be noted, can also can be spread via undercooked meat often attacks the retina, and ocular toxoplasmosis is one of the most common afflictions associated with Toxoplasma gondii. It can cause floaters that obscure ones vision and result in vision loss, and as Smith and Furtado wrote, it can scar the back of the eyeball, too.
In an analysis of Western Australias Busselton Healthy Ageing Study, which took retinal photographs of more than 5,000 baby boomers born between 1946 and 1964, they found that an alarming one in 150 of the eyeball photos showed signs of scarring from ocular toxoplasmosis.
As they noted, there is currently no drug or vaccine to stop or prevent toxoplasmosis infection, and with its estimated rates of prevalence in the global population, it makesToxoplasma the leader of the parasitic pack.
Toxoplasma gondii is probably the most successful parasite in the world today, the researchers wrote and its hard to argue with that conclusion given the numbers.
Heres hoping the experimental toxoplasmosis vaccines that have been cropping up over recent years gets to pharmacies and veterinarians sooner rather than later, because the last thing we need is a parasite in our eyeballs.
READ MORE: One in three people are infected withToxoplasma parasite and the clue could be in our eyes [The Conversation]
More on toxoplasmosis:Elon Musk Suggests That a Brain Parasite is Forcing Humans to Create Superhuman AI
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Reinventing the Workplace – MarketScale
Posted: at 7:47 pm
A futurologist, not to be confused with a futurist, refers to an artist of the 1900s artist movement Futurism. There are some crossovers. Both adore tech and love speed. Critically, a futurologist writes, speaks, and studies trends to forecast the future. Richard Watson, Futurist-In-Residence at Cambridge Universitys Judge Business School Entrepreneurship Centre, says that proper futurism sits somewhere between 10 to 20 years out. A prediction about three to five years ahead is basically talking about next Wednesday, and more than 20 years gets into sci-fi, said Watson.
A Racounter article explains that futurologists tend to be widely read and study trends to understand where the world is going next. Watson says futurologists are not going to get it 100% right, but you hopefully avoid being 100% wrong.
The last few years and the pandemic have brought tremendous changes in our daily lives. Few business leaders, who I am intimately aware of, seem to do anything other than react. That may have to do with the speed of change, says Mark Landini, Creative Director of Landini Associates. Watson poses that the innovative companies dont worry about what is going to happen. Theyre creating their own future, and everyone else can fall in line with it.
Remote work has become the norm and is widely expected. However, the concept isnt as new as we think. Landini referenced an interview with Arthur C. Clarke, in which he predicted the possibility of remote meetings more than fifty years ago. Thanks to the pandemic, weve adapted to remote opportunities. Weve been forced to be less physical, and within a few months, weve decided that we quite like that, said Landini. The Economist reported that before the pandemic, Americans spent 5% of their working time at home. By spring 2020, the figure was 60%.
Watson pointed out that many trends made mainstream by the pandemic were already happening on a smaller scale. Watson explains, I fail to think of a single thing with the pandemic that wasnt happening already. However, the pandemic acted as a global catalyst and sped up the adoption of trends. Challenges in the workplace as things return to normal, including conflicting needs and desires between managers and workers. Were at a stage where we have to find a sweet spot between generations, said Watson. Recreating symbiosis between different work styles is key to progress and success in a business.
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Cancer Genome Sequencing Market: Rising Incidences of Cancer across the Globe to Drive the Market – BioSpace
Posted: at 7:29 pm
Albany NY, United States: Cancer Genome Sequencing Market: Snapshot
Cancer genome sequencing market is anticipated to witness exponential growth during the forecast period of 2021-2031 due to emergence of next-gen sequencing technology that is offering exclusive sensitivity and resolution. Cancer genome sequencing is developing at a faster pace and can be altered in their gross chromosomal structure through amplification, Furthermore, the efforts to make it cost-effective and accurate, may generate ample revenue opportunities for the cancer genome sequencing market.
On the basis of technology the cancer genome sequencing market can be segmented into second generation technology platforms and third generation technology platforms. Further, the second generation technology platform can be classified into solid sequencing, pyro sequencing, and bridge amplification sequencing technology. The third generation technology platforms include single molecule real time sequencing, Nanopore sequencing, florescent resonant energy transfer sequencing.
The in-depth analysis performed by the team of analysts TMR provides all important information about the current market scenario. It assists the CXOs to make proper decisions regarding investments and collaborations. The factors that are taken into consideration are the market trends, key drivers, restrains, opportunities, and challenges in the cancer genome sequencing market.. The impact of COVID-19, in particular, is also covered in this report.
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Cancer Genome Sequencing Market: Key Trends and Opportunities
The rising incidences of cancer across the globe has led to the development of cancer genome sequencing for detecting copy number alterations, exome wide base substitutions, and translocations in all cancer cells easily. Taking all these aspects into consideration, the global cancer genome sequencing market may grow substantially. Significant rise in the geriatric population and the escalating rate of patients diagnosed with chronic diseases and cancer are increasing the demand for the cancer genome sequencing market. Thus, these aspects are likely to bring multiple growth opportunities for the market.
Cancer genome sequencing helps in the proper diagnosis of tumors irrespective of its location. It also helps in viewing the whole genome and has the ability to eliminate the requirement of having updates regarding patients history. Further, the personalization of cancer treatment is likely to be a growth booster for the cancer genome sequencing market in the coming years.
Development in computing power has led to wide range of applications in cancer genome sequencing market such as personalized medicine, detection of biomarker, and others. In addition, the improved and quick computing technologies in anticancer therapies and pharmacogenomics are likely to create multiple opportunities for the cancer genome sequencing market.
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Cancer Genome Sequencing Market: Competitive Insights
The key players are trying hard to make the sequencing technology cost effective by finding out alternatives that can be comparatively inexpensive. One such alternative is targeted gene sequencing method which is affordable and effective.
The key players are investing in research and development activities to innovate new technologies to upgrade their products. The key players are analyzing the prevailing opportunities to strengthen their market presence. The investments in R&D activities have led to replacing the traditional tools of genomics with technologically advanced cancer genome sequencing applications.
The key players operating in the Cancer genome sequencing market are Ambry Genetics, BGI Americas Corporation, Beckman Coulter Genomics, Illumina, Inc., Pacific Biosciences, and Pacific Biosciences
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Cancer Genome Sequencing Market: Regional Prospects
Cancer genome sequencing market can be segmented into North America, Europe, Asia Pacific, and LAMEA based on the regions. North America is anticipated to show a high growth trajectory in the cancer genome sequencing market due to the increasing awareness about cancer genome sequencing applications. Europe also may create multiple growth avenues for the global market owing to the rigorous R&D activities being conducted in this region.
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Digital Pathology Market: Rising awareness about digital pathology and increase in demand for advanced technology are the factors likely to boost the growth of digital pathology market. Moreover, high incidence and prevalence of cancer and other chronic diseases is poised to escalate the growth of digital pathology market.
Mechanical Ventilators Market: The global mechanical ventilators market is estimated to witness increased sales during forecast period. This increased sales rate is attributed to growing older population and rising cases of respiratory diseases. Mechanical ventilator is an artificial breathing device majorly used for treating patients with severe medical conditions.
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Most People With Hypermutated Genome Obtain Excess Mutations from Father, Study Finds – GenomeWeb
Posted: at 7:29 pm
NEW YORK While the human germline appears to be relatively impervious to acquiring many mutations, some genetic vulnerabilities or paternal exposure to chemotherapy can prompt pronounced de novo mutations, new research has found.
"Our results suggest that the germline is well protected from mutagenic effects, hypermutation is rare, the number of excess mutations is relatively modest, and most individuals with a hypermutated genome will not have a genetic disease," senior author Matthew Hurles, a researcher at the Wellcome Sanger Institute, and his colleagues wrote in Nature on Wednesday.
Following prior studies in mice with specific DNA repair mutations or mutagenic exposures, the team set out to search for signs of hypermutation in the human germline, where far less is known about individuals at the high end of the germline mutation spectrum.
Using exome or whole-genome sequence data for nearly 21,900 parent-child sets from the 100,000 Genomes Project or the Deciphering Developmental Disorders project including families with children suspected of having rare genetic conditions the researchers found a dozen participants who had up to seven times as many de novo single-base mutations in their germline than the median of other individuals.
In nine of the 12 individuals, the team traced the hypermutation back to their fathers. In some families, individuals carried damaging alterations affecting DNA repair genes, while others had germline mutation signatures linked to platinum-based chemotherapy, including children born to fathers who went through cancer treatment prior to conceiving children.
When the investigators explored the latter results further using data for dozens of parents from the 100,000 Genomes Project who had a history of cancer treatment, they found germline hypermutation in children born to two of 27 fathers treated for cancer. They also detected a nominal increase in de novo single-nucleotide changes in children born to mothers with a cancer treatment history, though the women also tended to be older than unaffected mothers when their children were born.
Among other implications, the results suggest that there may be a benefit for male cancer patients to preserve sperm prior to chemotherapy treatment, particularly for men who wish to have children in the future. At the moment, measures are typically offered to protect against chemotherapy-related infertility.
"Clinically, patients receiving chemotherapy who might want to go on to have children in the future are often offered the opportunity to freeze sperm prior to treatment as part of standard of care in the UK," Hurles explained in an email, adding that "it is not just cancer patients that receive mutagenic chemotherapies; these drugs are also given for non-cancer conditions, for example for immune suppression in some auto-immune disorders."
Although the evidence available so far suggests that the germline "generally appears to be well protected from large increases in mutation rate," the authors wrote, Hurles and his colleagues called for additional studies that include individuals exposed to a broader set of potential mutagens, and their family members, to find more modest germline mutation signatures and ties between genes and other environment factors.
"I anticipate that the publication of our study will trigger a range of future studies looking into the germline effects of a range of mutagens, including many chemotherapies," Hurles wrote. "I also think that more studies will identify genetic causes of hypermutation, and through these studies, we will learn more about the differences between the soma and the germline in terms of how mutations are minimized."
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Most People With Hypermutated Genome Obtain Excess Mutations from Father, Study Finds - GenomeWeb
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Horrifying Discovery: Scientists Find That DNA Mutations Are More Common Than Previously Thought – SciTechDaily
Posted: at 7:29 pm
Researchers at EMBL Heidelberg found that inversions in the human genome are more common than previously thought, which impacts our understanding of certain genetic diseases.
Our DNA serves as a blueprint for the cellular machinery that allows cells, organs, and even whole organisms to work. However, mutations in our DNA can cause genetic illnesses. Point mutations at a single site, as well as deletions, duplications, and inversions, are examples of such DNA mutations.
Inversion refers to a piece of DNA inverting its orientation in the genome. Because inversions are more difficult to analyze than other forms of mutations, they are poorly understood. Scientists from EMBL Heidelberg, working with colleagues from the University of Washington in the United States and Heinrich Heine University Dsseldorf in Germany, have determined that inversions are one of the most common mutational processes in humans.
The researchers uncovered how inversions are formed and investigated in detail a set of 40 inversions that form recurrently in the genome, where the DNA sequence flips back and forth. These flip-flopping inversions typically lie in regions linked to the development of certain human diseases called genomic disorders.
We found that inversions form at a much higher rate than previously thought. In humans, at least 0.6% of the genome repeatedly changes direction, making inversion one of the fastest mutational processes in humans, said Jan Korbel, EMBL Senior Scientist and Head of Data Science. At these sites, the genome is not stable the direction of the DNA code continues to switch back and forth.
These unstable areas are home to the many essential human genes. Scientific studies of long-distance gene regulation or epigenetics must now take into account this flipping behavior of genomic regions.
Artistic interpretation of inversions in the human genome. Credit: Isabel Romero Calvo/EMBL
Inversions are also relevant for the development of human diseases, such as developmental delays in children or neuropsychiatric disorders in adults. Despite their importance, these regions have been very difficult to study before because of their complexity. Showing that these inversions indeed flip-flop back and forth required a new set of computational methods, said Tobias Marschall, Director of the Institute of Medical Biometry and Bioinformatics and the Heinrich Heine University Dsseldorf. We can now provide human geneticists with a new tool to understand the origin of disease in their patients.
Evan Eichler, group leader at the University of Washington, said: We showed for the first time that inversions can be associated with rare genomic rearrangements found in pediatric autism, developmental delay, and epilepsy. The question now is why? We hypothesize that certain configurations at the flanks of the inversions either predispose or protect individuals and their offspring from disease-associated rearrangements. This could have a practical application in the clinic, where it could be used to identify families at risk for developing these disorders.
Reference: Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders by David Porubsky, Wolfram Hps, Hufsah Ashraf, PingHsun Hsieh, Bernardo Rodriguez-Martin, Feyza Yilmaz, Jana Ebler, Pille Hallast, Flavia Angela Maria Maggiolini, William T. Harvey, Barbara Henning, Peter A. Audano, David S. Gordon, Peter Ebert, Patrick Hasenfeld, Eva Benito, Qihui Zhu, Human Genome Structural Variation Consortium (HGSVC), Charles Lee, Francesca Antonacci, Matthias Steinrcken, Christine R. Beck, Ashley D. Sanders, Tobias Marschall, Evan E. Eichler and Jan O. Korbel, 6 May 2022, Cell.DOI: 10.1016/j.cell.2022.04.017
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Excision BioTherapeutics to Present Preclinical and Bioinformatic Data Showing Robust and Specific Editing of HIV Proviral DNA with EBT-101 at the…
Posted: at 7:29 pm
Excision BioTherapeutics
SAN FRANCISCO, May 17, 2022 (GLOBE NEWSWIRE) -- Excision BioTherapeutics Inc., a biotechnology company developing CRISPR-based therapies intended to cure viral infectious diseases, today announced that preclinical and bioinformatic data showing robust and specific editing of HIV proviral DNA with EBT-101 will be featured in an upcoming poster presentation at the American Society of Gene & Cell Therapy (ASGCT) 25th Annual Meeting, which is taking place at the Walter E. Washington Convention Center in Washington, D.C.
EBT-101 is a unique, clinical-stage, in vivo CRISPR-based therapeutic designed to functionally cure HIV infections after a single intravenous infusion. It employs an adeno-associated virus (AAV) to deliver CRISPR-Cas9 and dual guide RNAs targeting three sites within the HIV genome. Bioinformatic analyses featured in the ASGCT poster compare these EBT-101 target sites against the human reference genome and show no identical matches. Moreover, there are no candidate off-target sites in the human reference genome with only one or two differences from EBT-101 target sites, and only a single candidate off-target site with three differences. These findings predict a lack of off-target activity for EBT-101, which has been confirmed by in vitro and in vivo studies showing HIV excision without unintended editing.
Taken together, the data being presented at ASGCT highlight the key advantages of Excisions novel therapeutic approach, said TJ Cradick, Ph.D., Chief Scientific Officer of Excision and lead author on the poster. By leveraging our in-silico design platform, we carefully crafted EBT-101 to minimize viral escape and off-target effects by cutting at three target sites that are specific to the HIV genome. Latent viral reservoirs were eradicated in in multiple disease models and resulted in functional cures in transgenic mice. We are now working to build on these results through the advancement of EBT-101s recently initiated Phase 1/2 clinical trial, and look forward to discussing our program with the scientific community at the upcoming ASGCT meeting.
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The ASGCT poster, entitled, EBT-101 achieves robust CRISPR-based editing of HIV proviral DNA without detectable off-target effects, will be presented today from 5:30 6:30 PM ET during the Hematologic and Immunologic Disease II poster session (Board No. TU-205). The poster was authored in collaboration with researchers from institutions including Temple University and Dartmouth-Hitchcock Medical Center. A copy of the poster will be posted to the Excisions website following its presentation at the meeting.
About EBT-101
EBT-101 is a unique, in vivo CRISPR-based therapeutic designed to functionally cure HIV infections after a single intravenous infusion. It employs an adeno-associated virus (AAV) to deliver CRISPR-Cas9 and dual guide RNAs targeting three sites within the HIV genome. This novel approach enables the excision of large portions of the HIV genome, thereby minimizing potential viral escape. EBT-101 is being evaluated in clinical trials and is the only therapeutic candidate in history to achieve functional cures of HIV in animal models.
About Excision BioTherapeutics, Inc.
Excision BioTherapeutics, Inc. is a biotechnology company developing CRISPR-based therapies as potential cures for viral infectious diseases. Excision unites next-generation CRISPR nucleases with a novel gene editing approach and has become the first and only company in history to cure HIV with a therapeutic in an animal model. EBT-101, the companys lead program intended to cure HIV with a single IV infusion, is being evaluated in clinical trials. Excisions pipeline includes one-time potential cures for Herpes Virus, JC Virus, which causes PML, and Hepatitis B virus. The Companys foundational technologies were developed in the laboratories of Dr. Kamel Khalili at Temple University and Dr. Jennifer Doudna at University of California, Berkeley. For more information, please visit http://www.excision.bio.
Contacts:
InvestorsJohn FrauncesLifeSci Advisors917-355-2395jfraunces@lifesciadvisors.com
MediaRobert Flamm, Ph.D.Burns McClellan, Inc.212-213-0006 ext. 316 / 364rflamm@burnsmc.com
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Startup Genome and the Ministry of the Economy Launch a Study to Assess and Benchmark the Luxembourg Star – Benzinga
Posted: at 7:29 pm
SAN FRANCISCO - May 16, 2022 - (
)
The Ministry of the Economy launches a strategic initiative aimed at assessing the Luxembourg start-up ecosystem in order to identify further steps to bring the ecosystem towards a next level of development over the upcoming years.
The Luxembourg start-up ecosystem has been on a constant rise over the past decade. In its latest mapping (www.startupluxembourg.com/why-luxembourg/ecosystem-mapping), Luxinnovation, the Luxembourg's national innovation agency, identified more than 500 start-ups active in developing and offering innovative digital and data driven solutions, mostly in the key fields of economic diversification.
Luxembourg has an established history of empowering innovators, entrepreneurs, and investors to implement their vision and contribute to economic diversity through regional and globally competitive enterprises.Given Luxembourg's central position in the European single market, highly advanced legislative and regulatory frameworks and competitive digital infrastructure, the start-up ecosystem attracts innovative professionals and start-up companies from all over the world.
In order to gain a more granular view of the Luxembourg start-up ecosystem and its international positioning, an assessment and a benchmarking will start in May. This assessment and benchmarking will provide a thorough qualitative and quantitative understanding of the Luxembourg start-up ecosystem, based on data analysis, information gathered from the start-up community and interviews with key stakeholders. The study will provide relevant comparisons with international peers, highlighting potential future development opportunities as well as ecosystem success factor strengths and gaps.
Startup Genome, a leading research and policy advisory organization specialized in the analysis of start-up ecosystems was chosen to carry out this assessment and benchmarking in close collaboration with the dedicated team at the Ministry of the Economy and at Luxinnovation. In this process, Startup Genome will leverage its experience of over 200 ecosystems worldwide and the knowledge and data gathered through its yearlyGlobal Startup Ecosystem Report (GSER).
Within the context of the study and in order to collect the feedback from the start-up community, Startup Genome will reach out to entrepreneurs with a dedicated survey. Start-ups and entrepreneurs willing to take the survey and give their input can find more information on http://www.startupluxembourg.com.
The results of the study as well as a consultation process with key stakeholders of the ecosystem will be taken into account for the elaboration of a strategic roadmap for the further development of the Luxembourg start-up ecosystem.
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Startup Genome and the Ministry of the Economy Launch a Study to Assess and Benchmark the Luxembourg Star - Benzinga
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Android app deals of the day: EZ Voice Notes, Jumanji, Galaxy Genome, and more – 9to5Toys
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Android app deals of the day: EZ Voice Notes, Jumanji, Galaxy Genome, and more - 9to5Toys
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