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Category Archives: Transhuman News
Dendritic cells affect onset and progress of psoriasis
Posted: September 13, 2014 at 1:42 pm
PUBLIC RELEASE DATE:
12-Sep-2014
Contact: Barry Whyte barry.whyte@embo.org EMBO @EMBOcomm
Different types of dendritic cells in human skin have assorted functions in the early and more advanced stages of psoriasis report researchers in the journal EMBO Molecular Medicine. The scientists suggest that new strategies to regulate the composition of dendritic cells in psoriatic skin lesions might represent an approach for the future treatment of the disease.
"We urgently need new ways to treat psoriasis, treatments that will deliver improved benefits to patients and reduce the incidence of known side effects for existing drugs," says EMBO Member Maria Sibilia, a Professor at the Medical University of Vienna in Austria, and one of the lead authors of the study. "Our experiments have revealed that increases in the number of plasmacytoid dendritic cells are important early triggers of the disease while other types of dendritic cells, the Langerhans cells, help to protect the balance of the immune response that is established during inflammation of the skin."
Psoriasis is an autoimmune disease that affects around 125 million people worldwide. Symptoms, which include the formation of red inflamed lesions that appear on the skin, vary from mild to severe. The disease is often associated with other serious health conditions such as diabetes, heart disease and depression.
The researchers observed an increase in the accumulation of plasmacytoid dendritic cells in the psoriatic lesions of patients as well as in mice that are model organisms for the study of the disease. Plasmacytoid dendritic cells are a specific type of immune cell that can infiltrate damaged tissue during the early phase of psoriasis. In contrast, the levels of another type of dendritic cells known as Langerhans cells, were significantly decreased in the lesions compared to healthy skin in humans and mice. If the levels of plasmacytoid dendritic cells in mice were decreased during the early stages of the disease then the symptoms of psoriasis were quelled. A similar decrease in Langerhans cells at an early stage of the disease had no effect. If the levels of Langerhans cells were reduced at advanced stages of the disease, the symptoms of psoriasis were exacerbated.
"The changes in the severity of symptoms we have observed related to changes in the composition of dendritic cells most likely impact the balance of inflammatory mediators at the site of disease. It may well be that by inducing favourable compositions of dendritic cells at the early stages of psoriasis we may be able to help reduce the effects of psoriasis by achieving a better balance of these mediators at the site of the disease. Further work is needed before we can say with any certainty if such an approach will lead to a viable clinical treatment for psoriasis."
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Specific roles for dendritic cell subsets during initiation and progression of psoriasis
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Mushroom Kingdom Meltdown–Episode 10: Still Politically Incorrect – Video
Posted: at 1:41 pm
Mushroom Kingdom Meltdown--Episode 10: Still Politically Incorrect
Still on my soapbox as we finish World 5. Levels Covered: Aquatic 2 (secret) Coastal Ghetto 5 (secret) Collection Castle.
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Mushroom Kingdom Meltdown--Episode 10: Still Politically Incorrect - Video
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Irreverent road-trip comedy banks on women power
Posted: at 1:41 pm
NOW SHOWING By Rito P. Asilo | Philippine Daily Inquirer
MCCARTHY, BATES AND SARANDON. Romance isnt the only thing that makes their journey eventful.
There are crass jokes and politically incorrect situations in Ben Falcones Tammybut, the cool confidence of the films supporting actresses, Susan Sarandon, Kathy Bates and Sandra Oh, rub off on the movie and its polarizing lead star, Melissa McCarthy. The characters the trio portrays dont always make the right decisions in life, but they stand by their choices and refuse to get trapped in the perceived limitations of their gender.
For her part, the 44-year-old, Oscar-nominated actress is cast as a woman who doesnt mind getting on everybodys bad sidewhich is similar to many of her past roles (Bridesmaids, The Heat, Identity Thief).
When Tammys car hits a deer on her way to work, the accident sets off a series of unfortunate situations that expose her to further abuse: She gets fired for reporting late for work and catches her husband (Nat Faxon) having a romantic dinner with their next-door neighbor (Toni Collette)!
She goes on a road trip and grudgingly agrees to let her grandmother, Pearl (Sarandon), tag along (its her car and money). Unlike Tammy, who doesnt know where shes headed, Pearl wants to go all the way to Niagara, about a thousand kilometers awayto make her childhood dream a reality!
Something unexpected
Then, something unexpected happens when Tammy and Pearl meet Bobby (Mark Duplass) and his father, Earl (Gary Cole), during a stopover in Kentucky, halfway through their journeysparks fly!
Romance isnt the only thing that makes the journey of this mismatched pair eventful: Someone is hauled off to prison, while the other is forced to rob a shopdire situations that compel a pair of married lesbians to come to their rescue! Thankfully, the couple isnt used as fodder for silly gender jokes, but provides surprising lessons about fighting for things that truly matter.
The films irreverent humor is too in-your-face and broad to pass for sophisticated comedy some of its jokes work, while others dont. However, its refreshing to see headstrong women do crazy things that are often only expected from men and its even more comforting to hear them owning up to their faults, and learning from them!
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Irreverent road-trip comedy banks on women power
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Peruchaazhi lands in soup
Posted: at 1:41 pm
Special arrangement Veteran film director Harikumar is making a film on the late child artist prodigy Clint (in the photo along with his parents).
If the cold reception from the fans as well as the general audience was not enough, Mohanlals Onam release Peruchaazhi has now landed in the soup over a few politically incorrect dialogues in its script.
One of the dialogues delivered by Vijay Babus character in the film has been deemed derogatory of those hailing from Attappady. Though a few critics had raised the issue at the time of the release, things actually heated up two days back with director Biju Damodaran putting up a Facebook post against such insensitiveness. He particularly held the superstar himself responsible for this and criticised him for promoting such regressive thinking.
Now, the actors fans, known to be intolerant of even mild criticism of the man, attacked Mr. Biju verbally on his page. Some of the comments mirrored the insensitive dialogue in the film, thus vindicating the directors stand that such lines have a huge impact on the viewers. The fans are of the opinion that the star cannot be held responsible for what the scriptwriter has written.
Last checked, the fans are still hunting him in packs, a la Sachin-Sharapova episode.
Some of the other sequences in the film, including that of the star creating racial tension for the sake of a few votes, have also been criticised for political incorrectness. Though it has been explained away as a reflection of real life, critics have pointed at how it is all depicted in a positive light, as a sign of intelligence of the star.
******
Clint will remain a sorrow for Malayalis always. He had died, in 1983, at the age of six, after leaving behind about 25,000 paintings. Paintings that belied his age.
Two decades after his death, veteran director Harikumar is making a film on the prodigys life.
I felt Clints extraordinary life needed to be told on celluloid, says the director of films such as Sukrutham, Ayanam and Udyanapalakan. A few days ago, I discussed the possibility of such a film with M.T. Vasudevan Nair, who also encouraged me to work on it.
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FUNNY RomanAtwoodVlogs Unnecessary Censorship (CENSORED)! – Video
Posted: at 1:41 pm
FUNNY RomanAtwoodVlogs Unnecessary Censorship (CENSORED)!
subscribe: http://www.youtube.com/user/LSWLaughing?sub_confirmation=1 RomanAtwoodVLOGS Unnecessary Censorship ( PART 1 ) I Hope you like it guys!! please like and subscribe for more videos...
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Ron Paul's 'Audit the Fed' bill returns to Congress
Posted: at 1:41 pm
Ron Paul may not be in Congress anymore, but his Audit the Fed bill lives on after him.
House Republican leaders scheduled a vote on the legislation for sometime in the next week, as one of a series of pre-election bills designed to highlight lawmakers stances just before they go home to face voters.
Mr. Paul made the bill one of his causes, and after years of trying finally pushed it through the House in 2012 on an overwhelming 327-98 vote. But Senate Majority Leader Harry Reid, who had previously said he supported an audit of the Federal Reserve, reversed himself.
If Harry Reid refuses to hold the vote before the Senate leaves town, you can help us make sure the American people hear about it all the way until Election Day and build so much pressure by the time Congress returns, the Senate will be forced to act in the Lame Duck, Mr. Paul said in an email to supporters from his advocacy group, Campaign For Liberty.
Mr. Paul retired from the House after the last Congress. The current House version of the legislation is sponsored by Rep. Paul Broun, a Georgia Republican. His version cleared the House oversight committee on a voice vote in July, suggesting continued bipartisan support.
The bill would order the Government Accountability Office, which is Congresss chief investigative arm, to review the Feds decision-making particularly on monetary policy.
Congress established the Federal Reserve nearly a century ago. The system, which consists of a board of governors and 12 regional banks, act as lenders of last resort to the countrys banking system, and it is charged both with fighting inflation and with promoting economic growth and employment.
The Congressional Budget Office said the bill would cost about $5 million for the staff required to conduct the audit. The CBO also said the Federal Reserve would spend money complying with the review, which would end up costing the government about $3 million in lower revenue from the Fed over the next decade.
The previous chairman of the Federal Reserve, Ben Bernanke, had opposed an audit, saying it could lead to politicians second-guessing the secretive boards decisions. When Mr. Pauls bill came up for a vote in 2012, Mr. Bernanke called it a nightmare scenario.
Mr. Pauls son, Sen. Rand Paul, Kentucky Republican, has a companion bill in the Senate, but that has not seen any action with Democrats controlling the chamber.
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Catholicism and libertarianism clash over property and the common good
Posted: at 1:41 pm
Editor's note: Michael Sean Winters is on vacation this week. Filling in for him are various writers from Millennial, a journal featuring the writing of millennial Catholics. Winters will be back next week.
It seems our ongoing religious consideration of the merits of libertarianism has come at precisely the right time. With The New York Times wondering if the "libertarian moment" has come -- and substantially lesser venues hoping that it has -- now is the time for a definitive Christian ethical case to be taken up with regard to libertarianism. Such a case is being mounted with increasing vigor. Yet while Vatican officials disown libertarianism and all Pope Francis' statements on politics militate firmly against it, a loud portion of American Catholics in the political realm seem doggedly committed to it. Why?
One source of libertarian sentiment among Catholics is likely, as argued by Meghan Clark, the popularity of a certain mistaken anthropology. By this, Clark means a story about what type of creature man is and what his purpose is that has been fundamentally divorced from the biblical narrative and tradition by vested political interests. Clark points out that the chief feature of this warped anthropology is its naked individualism and its inability, therefore, to grasp the necessity of solidarity in producing whole and morally upright people. For the radically individualistic libertarian, solidarity is a burden, not a boon. If it is a boon, it is only so insofar as it produces certain desired outcomes for the individual -- but this utilitarian understanding of solidarity is, as Clark demonstrates, a far cry from the real thing.
Clark is right to note the failed anthropology at the heart of libertarianism. But yet another thematic failure animates libertarian philosophy as well: a vital misapprehension of the nature and purpose of property.
One thing to note about libertarianism is that it is first and foremost liberal, in the sense of classical Enlightenment liberals like John Locke. Liberalism arose as a political philosophy at a time when hostility to the Catholic church was well received, and many assumptions that contradict truths held obvious and foundational by the Catholic church remain tied up in liberal, and therefore libertarian, reasoning. Chief among them is the philosophical preference for the primacy of private property rights over all other institutions or conditions, including the common good. Consider Murray Rothbard, arguing that all rights disputes are little more than disputes of private property:
There are other vexed problems which would be quickly cleared up in a libertarian society where all property is private and clearly owned. In the current society for example, there is continuing conflict between the "right" of taxpayers to have access to government-owned streets, as against the desire of residents of a neighborhood to be free of people whom they consider "undesirable" gathering in the streets. ... They are, in brief, complaining about the "human right" of certain people to walk at will on the government streets. But as taxpayers and citizens, these "undesirables" surely have the "right" to walk on the streets, and of course they could gather on the spot, if they so desired, without the attraction of McDonald's. In the libertarian society, however, where the streets would all be privately owned, the entire conflict could be resolved without violating anyone's property rights: for then the owners of the streets would have the right to decide who shall have access to those streets, and they could then keep out "undesirables" if they so wished.
It is a foregone conclusion in Rothbard's ethics that owners of property have the absolute right to exclude people from what they own, be it land or material objects, even in the case of individuals who have nowhere else to go -- as "undesirables" here surely refers to homeless people who congregate in or near fast food restaurants for warmth and shelter. Rothbard flatly does not see the need to argue for such a right on behalf of owners, but smoothly progresses from the problem of "undesirables" to the "cure" of private property ownership: If only land held in common were held privately, he laments, you would presumably never have to see another "undesirable" for any longer than it took you to banish them. That your ownership claim supersedes their right to shelter, warmth, perhaps even food -- is simply assumed.
Libertarian luminary Hans Hermann Hoppe makes this claim explicit, writing:
It becomes apparent that nothing could be further from the truth as soon as one explicitly formulates the norm that would be needed to arrive at the conclusion that the state has to assist in the provision of public goods. The norm required to reach the above conclusion is this: whenever one can somehow prove that the production of a particular good or service has a positive effect on someone else but would not be produced at all or would not be produced in a definite quantity or quality unless certain people participated in its financing, then the use of aggressive violence against these persons is allowed, either directly or indirectly with the help of the state, and these persons may be forced to share in the necessary financial burden.
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CBS Executive Declares He is Immortal – Billionaire Transhumanist Sumner Redstone’s Scary Quest – Video
Posted: at 1:41 pm
CBS Executive Declares He is Immortal - Billionaire Transhumanist Sumner Redstone #39;s Scary Quest
CBS Executive Declares He is Immortal - Billionaire Transhumanist Sumner Redstone #39;s Scary Quest. *SUBSCRIBE* for more great videos! Mark Dice is a media analyst, author, and political activist...
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"Building a Transhuman Social Movement" by Darshan Elena Campos – Video
Posted: at 1:40 pm
"Building a Transhuman Social Movement" by Darshan Elena Campos
Global Existential Risks Radical Futures" ~ H+X Conference H+X Conference (Transhuman Visions), June 14, 2014 more info: http://www.hplusx.com http://www...
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Crysis 3 Let’s Play: Post Human – Video
Posted: at 1:40 pm
Crysis 3 Let #39;s Play: Post Human
I die over and over fighting Cell guys. 5 likes.
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