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Category Archives: Transhuman News

Bacterial genome important to fuel and chemical production sequenced

Posted: September 30, 2014 at 1:43 am

Researchers at the Department of Energy's Oak Ridge National Laboratory are the first team to sequence the entire genome of the Clostridium autoethanogenum bacterium, which is used to sustainably produce fuel and chemicals from a range of raw materials, including gases derived from biomass and industrial wastes.

The ORNL work was funded by LanzaTech, a biotechnology company based in Illinois with an innovative carbon recycling process. LanzaTech's gas fermentation platform uses proprietary microbes for efficiently converting carbon-rich waste gases and residues into useful fuels and chemicals.

Successfully sequencing Clostridium autoethanogenum -- classified as a complex, class III microbe because of its many repeating units of DNA bases -- has been of significant interest to the biotechnology industry. A Biotechnology for Biofuels paper co-authored by ORNL's Steve Brown and Miriam Land, University of Tennessee doctoral student Sagar Utturkar and collaborating LanzaTech researchers generated a top-5-percent rating from Altmetric, an online rating system that measures the volume and value of recognition an article receives from research communities and media outlets.

"With the complete genomic sequence, we will have a better understanding of the microbe's metabolism and mutations that will enable LanzaTech to make modifications to the wild-type, or naturally occurring, strain for optimizing the conversion of waste into fuel," Brown said. "Our ORNL lab has a lot of experience sequencing genomes, and we have the analytic capability to tackle this project."

The research team sequenced the more than 4.3 million base pairs of DNA that make up the organism's genome using RS-II long-read sequencing technology developed by Pacific Biosciences (PacBio).

Although long-read sequencing technologies still struggle with high error rates, they promise to advance the biotechnology industry by making it possible to sequence microorganisms with many repeating sequences, such as Clostridium autoethanogenum, within a reasonable amount of time at reasonable cost. The ORNL team performed a greater number of reads and used data algorithms to correct for errors associated with the long-read technology. The team also compared the RS-II long-read results to two short-read technologies, concluding the short-read technologies were unable to sequence the entire genome because of the bacterium's repetitive sequences, as expected.

"In our paper we compared three generations of sequencing technologies and explained why the long-read technology was able to finish the genome," Brown said. "Now, ORNL is independently looking at six different organisms using PacBio to compare and contrast experiences using this technology."

The project also revealed information about the genetic history of Clostridium autoethanogenum through short DNA sequences known as CRISPR systems, which retain genetic mutations such as those created during a viral infection that are subsequently passed on to future generations of a microbe. CRISPR systems are important indicators of strengths and vulnerabilities that biotechnology companies like LanzaTech look for when genetically modifying a microbe.

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The above story is based on materials provided by Oak Ridge National Laboratory. Note: Materials may be edited for content and length.

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Stanford scientists say drought linked to climate change

Posted: at 1:43 am

By Ker Than

Associate Professor Noah Diffenbaugh and graduate student Daniel Swain explain the 'ridiculously resilient ridge' and its role in the California drought.

The atmospheric conditions associated with the unprecedented drought currently afflicting California are "very likely" linked to human-caused climate change, Stanford scientists write in a new research paper.

In a new study, a team led by Stanford climate scientist Noah Diffenbaugh used a novel combination of computer simulations and statistical techniques to show that a persistent region of high atmospheric pressure hovering over the Pacific Ocean that diverted storms away from California was much more likely to form in the presence of modern greenhouse gas concentrations.

The research, published on Sept. 29 as a supplement to this month's issue of the Bulletin of the American Meteorological Society, is one of the most comprehensive studies to investigate the link between climate change and California's ongoing drought.

"Our research finds that extreme atmospheric high pressure in this region which is strongly linked to unusually low precipitation in California is much more likely to occur today than prior to the human emission of greenhouse gases that began during the Industrial Revolution in the 1800s," said Diffenbaugh, an associate professor of environmental Earth system science at Stanford and a senior fellow at the Stanford Woods Institute for the Environment.

The exceptional drought currently crippling California is by some metrics the worst in state history. Combined with unusually warm temperatures and stagnant air conditions, the lack of precipitation has triggered a dangerous increase in wildfires and incidents of air pollution across the state. A recent report estimated that the water shortage would result in direct and indirect agricultural losses of at least $2.2 billion and lead to the loss of more than 17,000 seasonal and part-time jobs in 2014 alone. Such impacts prompted California Gov. Jerry Brown to declare a drought emergency and the federal government to designate all 58 California counties as "natural disaster areas."

Scientists agree that the immediate cause of the drought is a particularly stubborn "blocking ridge" over the northeastern Pacific popularly known as the Ridiculously Resilient Ridge, or "Triple R" that prevented winter storms from reaching California during the 2013 and 2014 rainy seasons.

Blocking ridges are regions of high atmospheric pressure that disrupt typical wind patterns in the atmosphere. "Winds respond to the spatial distribution of atmospheric pressure," said Daniel Swain, a graduate student in Diffenbaugh's lab and lead author of the study. "We have seen this amazingly persistent region of high pressure over the northeastern Pacific for many months now, which has substantially altered atmospheric flow and kept California largely dry."

Blocking ridges occur periodically at temperate latitudes, but the Triple R was exceptional for both its size and longevity. While it dissipated briefly during the summer months of 2013, it returned even stronger by fall 2013 and persisted through much of the winter, which is normally California's wet season.

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Eczema Skincare | What Works For Us! – Video

Posted: at 1:43 am


Eczema Skincare | What Works For Us!
Here #39;s what has worked for us when it comes to Ikaika #39;s eczema skin care. It #39;s not anything fancy, just treat and moisturize! Hope this helps! Enjoy!

By: LuLewbelle

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Eczema Skincare | What Works For Us! - Video

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Nummular Eczema Treatment Explained – Video

Posted: at 1:43 am


Nummular Eczema Treatment Explained
Nummular Eczema Treatment Explained Eczema or dermatitis, one of the most common skin complaints, has affected the young and old globally. Although there is no definite cure for it, eczema...

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Painful Eczema Symptoms? How You Can Reduce Eczema Symptoms Within Three Months – Video

Posted: at 1:43 am


Painful Eczema Symptoms? How You Can Reduce Eczema Symptoms Within Three Months
Painful Eczema Symptoms? How You Can Reduce Eczema Symptoms Within Three Months If you suffer from eczema then you know the pain of that dry itchy skin. An eczema breakout can mean skin irritatio...

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Painful Eczema Symptoms? How You Can Reduce Eczema Symptoms Within Three Months - Video

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Facts About Eczema Herpeticum – Video

Posted: at 1:43 am


Facts About Eczema Herpeticum
Facts About Eczema Herpeticum Eczema herpeticum is not a very common kind of disease related to the skin. This is caused by a virus called herpes simplex. There #39;s not a strong determinant...

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Best Medicine For Eczema – Video

Posted: at 1:43 am


Best Medicine For Eczema
Eczema: http://www.curediseasesinsights.com/eczema/ Eczema is a condition that makes your skin red and itchy. It #39;s common in children but can occur at any age. Atopic dermatitis is long lasting...

By: Madison Tisdale

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Glendale Chiropractor | Chiropractic Care for Eczema Treatment – Video

Posted: at 1:43 am


Glendale Chiropractor | Chiropractic Care for Eczema Treatment
Glendale Chiropractor | http://www.elitechiropracticandwellness.com Elite Chiropractic and Wellness welcomes anyone having a variety of pains and issues such as car accident injuries, neck...

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Tampa dermatologist commences clinical trial for eczema

Posted: at 1:43 am

Tampa dermatologist Dr. Seth Forman is currently conducting a clinical trial in hopes of finding a breakthrough treatment that will relieve those suffering from eczema.

Even though the clinical trial has already begun, the Tampa dermatologist is still looking for new patients with eczema.

This is a great opportunity for eczema sufferers to receive a one-of-a-kind, breakthrough treatment, says Dr. Forman. The hope is that by the end of the trial, patients will see noticeable improvement in their once problematic areas, relieving the unappealing look and annoying itch that comes with it.

Also known as atopic dermatitis, eczema is a medical skin condition characterized by inflammation and irritation of the epidermis. Common symptoms include itchiness and dryness of the skin and a development of thick red patches on areas of the body including the face, hands and neck.

Patients enrolled in the trial will receive subcutaneous (injected under the skin) medication at no cost, as well as free lab tests and exams by the Tampa dermatologist and his office. In addition, volunteers will be compensated for their participation in the research study.

Atopic dermatitis can cause a terrible itch, as well as be unsightly and unpleasant to live with, says Dr. Forman. We are looking for a treatment that can effectively improve the lives of those who have suffer from the condition.

Dr. Forman is the founder of Forman Dermatology and Skin institute, located in Tampa, Fla. and has appeared on TV shows across the country, including the nationally syndicated show The Doctors to provide sun-protection tips and to demonstrate his breakthrough skin cancer treatments.

If interested in being a part of the clinical trial for eczema, or for more on Dr. Seth Forman, Tampa dermatology or Forman Dermatology and Skin Cancer Institute, please visit http://www.FormanDerm.com.

About Dr. Seth Forman: Dr. Forman is a board-certified dermatologist practicing in Tampa, Florida. He was voted the Best Dermatologist in Carrollwood in 2011 and 2012 by the Carrollwood News and Tribune. In December 2011, he opened his new Tampa dermatology office, Forman Dermatology and Skin Cancer Institute, where he gives psoriasis sufferers access to the latest treatment options, including topical and oral medications, as well as biological and phototherapy. Dr. Forman is one of the few Tampa dermatologists to offer narrowband light therapy, which uses pharmaceutical grade light to suppress psoriasis. Hes also one of the few board-certified dermatologists in the U.S. to use the SRT-100 radiotherapy to treat basal cell carcinoma, the most common form of skin cancer.

MEDIA CONTACT Nathan Legg PR Firm: The Publicity Agency Email: Nathan@Seligmultimedia.com Phone: (813) 708-1220 x 7781 Website: http://www.thepublicityagency.com

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Psoriasis Remedies How To Cure Psoriasis Fast – Video

Posted: at 1:42 am


Psoriasis Remedies How To Cure Psoriasis Fast
Click here: http://www.sniplink.info/RHAR56 for *much* more information.

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