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Polygenic Risk Score Performance Improved With Expression-Related Rare Variant Insights – GenomeWeb
Posted: May 25, 2022 at 4:27 am
NEW YORK A team from Stanford University and other centers in the US and China have demonstrated that polygenic risk scores (PRS) based on common variants can be bolstered by incorporating clues from rare variants linked to significant gene expression shifts, dubbed expression outliers.
"As individual PRS estimates are comprised of variants across hundreds to thousands of genes, we reasoned that the disease effects of outlier-associated rare variants might have the greatest impact in individuals with a relatively larger burden of outlier-associated rare variant effects mapping to disease-relevant genes," Stanford University researchers Craig Smail and Stephen Montgomery, first and senior authors on a studyappearingin the American Journal of Human Genetics on Wednesday, explained in an email.
Using genotyping data from UK Biobank participants, together with expression quantitative trait locus data from the GTEx project and a computational method known as CrossMap that takes rare variant-related gene expression changes into account, the researchers first flagged rare variants with outsized effects on gene expression.
From nearly 1.8 million rare variants found in the UK Biobank set and in the gnomAD database, they flagged nearly 90,900 rare outlier variants that appeared to impact the expression of 15,871 genes, based on rare variant annotations gleaned from whole-genome and transcriptome sequences in version 8 of the GTEx.
From there, the team used its "independent outlier gene count" (IOGC) score to demonstrate that the expression outlier-related rare variants could improve the performance of body mass index (BMI) PRSs in more than 96,600 of the UK Biobank participants, distinguishing between individuals at higher or lower risk of so-called severe obesity or early bariatric surgery findings that were further validated using data for Million Veteran Program participants.
"We have demonstrated that a high burden of rare variants identified by their association with outlier gene expression can lead to substantial deviations in PRS-predicted phenotype," the authors wrote. "Furthermore, by integrating these rare variants into genetic risk prediction using the IOGC score, we demonstrated improvements in predicting risk for obesity beyond what was achievable with common variant-based PRSs."
In particular, the investigators found that predictions made using expression outlier-linked rare variants outperformed those possible by incorporating insights on protein-truncating rare variants into PRSs. Based on UK Biobank GWAS data spanning more than 1,900 traits or conditions, meanwhile, they saw signs that gene expression outlier-linked variants were somewhat enriched compared to rare variants that did not shift gene expression.
The findings so far suggest that "prediction for multiple complex diseases will benefit from integrating outlier-associated rare variants, including coronary heart disease, type 2 diabetes, and breast cancer," Smail and Montgomery wrote, noting that preliminary work points to improved predictive accuracy in at least two populations, hinting that a similar strategy may boost efforts to apply PRSs in non-European cohorts.
The investigators cautioned that the current approach is reliant on rare variant annotation insights from a relatively small set of GTEx representatives so far, and may be further improved by tapping into growing RNA sequence datasets and resulting variant-gene expression annotations. Likewise, whole-genome sequences from the UK Biobank project are expected to reveal far more rare variants missed with more limited sequence data used in the current analysis.
Consequently, Smail and Montgomery called the current work "a baseline for phenotypic prediction of complex diseases by integrating outlier-associated rare variants."
"Future extensions to our model will include more rare variants as we continue to sequence both transcriptomes and genomes in populations, will look at tissue-specific outlier effects, and incorporate longer-range gene expression impacts such as outlier-associated rare variants in enhancer regions," they noted.
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Why some ancient societies were more unequal than others – BBC
Posted: at 4:27 am
This kind of first-degree offspring is extraordinary, only having been cited in royal families of the past headed by god-kings such as the Egyptian pharaohs seeking to maintain a pure dynastic bloodline. (It is known, for instance, that Akhenaten married his eldest daughter, Meritaten, and much later, Ptolemy II married his sister, Arsinoe II hence his nickname, "Philadelphus" or "sibling loving.") It has been suggested that this Neolithic elite may have claimed to possess divine powers to ensure the continuity of agricultural cycles by keeping the Sun's movements going.
The findings support the notion that these Neolithic communities were socially stratified and that the massive stone structures were used to bury transgenerational patrilineal members of these clans. Perhaps equally interesting is the fact that in one case relatives were separated by up to 12 generations, pointing to an unusual stability through time of both the funerary tradition and the stratified society where they lived.
We have seen several case studies of past inequality correlating funerary archaeology with genetics that might no longer apply today, where legal regulations (and also the exponential increase of cremations) represent a certain degree of standardisation in funeral practices. Nevertheless, an opposite trend could shape thefuture of the archaeology of death: the trend toward personalised coffins, unconventional funerary memorials, and special grave goods. One way or another, mortuary archaeology will always be an important subfield of this discipline, and one that will need to rely on the hard sciences such as genetics and forensics.
Perhaps one encouraging conclusion is that despite what we have seen on the archaeology of past inequality, societies have been able to evolve and change their social stratifications. One example is Iceland the country has become one of the most egalitarian societies in the world. In 2018, Iceland passed a law that all companies employing more than 25 people will have four years to ensure gender-equal payment because, according to the head of the Equality Unit at Iceland's Welfare Ministry, "equality won't come about by itself, from the bottom up alone".
* This is an edited version of an article thatoriginally appearedinThe MIT Press Reader, and is republished with permission.
--
Carles Lalueza-Foxis Research Professor and Director of the Paleogenomics Lab at the Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra) in Barcelona. He participated in the Neanderthal Genome Project and led the first retrieval of the genome of an 8,000-year-old European hunter-gatherer. He is the author of Inequality: A Genetic History, from which this article is adapted (this is an edited version of the original MIT Reader piece).
--
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Top 10 Benefits Of Putting All Your Money Into Gold – The Babylon Bee
Posted: at 4:20 am
Brought to you by:
Enjoy eating food? Like having a healthy family? Then you'd better drop all your money into gold right now!
Still not convinced? Check out these amazing benefits:
1) As far as we know, the Federal Reserve hasn't figured out how to print gold yet: Which means they won't be able to crater its value.
2) It's shiny: And yellow-ish!
3) You'll be able to get James Bond's autograph before you cut him in half with a laser: Make sure to get his autographbeforeattempting to kill him.
4)When it's time to withdraw your retirement, the bank will put it in a complimentary pirate's chest: Neat!
5) You can use the word "doubloons", which is an awesome word: You'll be the envy of all your friends.
6) Impress your date after an expensive dinner when you drop a gold brick on the table and say I think that should cover it: Nice power move.
7)Can melt down and mold into an image of a calf to worship: You'll be the coolest guy at your impromptu wilderness party.
8)Forgea ring into which you pour your cruelty, malice, and will to dominate all life: With enough effort, you can turn into a giant flaming eyeball.
9)Can bury it in the backyard then forget where you buried it and on your deathbed whisper there's a gold bar somewhere in the backyard"and make your kids regret selling your house and moving you into a nursing home:Classic!
10) Ron Paul said so: He's been right about so many things. It'd be a mistake to ignore him now.
NOT SATIRE:No one is going to protect your retirement but you. Lets face it. Our economy is struggling. Experts say the dollar is collapsing. Inflation is at 40-year highs and economists and many Americans dont have faith that the Fed can or will fix it. So, why would you trust them to protect your financial future? With the ongoing economic and geopolitical crises, experts are worried that investors dont have a safe corner to hide in the stock, bond, and crypto markets. Nows the time to safeguard your retirement by investing in precious metals. Gold has proven to be a safe haven that holds its value during times of economic crisis.
Claim your FREE guide to see how precious metals can protect everything youve worked for.
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Susan K. Averitt – The Daily Globe – Your Daily Globe.com
Posted: at 4:20 am
IRONWOOD, Mich. Susan K. Averitt, 75, of Ironwood, passed away peacefully on May 17, 2022.
On Feb. 9, 1947, Sue was born in Ironwood, the daughter of the late Eugene and Ann (Lopez) Jacquart. She attended school in Ironwood and graduated from St. Ambrose High School in 1965. Sue then attended Gogebic Community College and worked as an LPN for some time after completing the nursing program.
Sue dedicated her life to raising her three boys: Jim, Dan and Nick. She loved children and operated a residential daycare for several different children over the years that she cared for greatly.
Sue loved a good TV crime drama and her Hallmark movies. In addition, she loved to knit and spend her time working on Word Seek puzzle books and enjoyed watching the Minnesota Vikings during the NFL season. She also had a special love for dogs, especially Old English Sheepdogs, of which she had three over the years.
Surviving are Sues two sons, Dan Averitt of Minneapolis, Minnesota, and Nick (Krystal) Averitt of Burnsville, Minnesota; grandchildren, Brayden Averitt, Kate Averitt, Ian Averitt, Marshall Averitt and Louis Averitt; great-grandchildren, Layla Averitt and Leo Averitt-Foster; sister, Mimi (Chatsie) Moncher; brothers, Don (Diane) Jacquart and Ron (Gary) Jacquart; nephew Paul (Christy) Jacquart; nieces, Jamey Jackson, Anney Jackson, Joey Jackson, Toni (Kevin) Hogan, Leslie (Matt) Young and Jeanine Bessette; cousins, Kathy (Fred) Friedman and Bob (Denise) Jacquart; daughter-in-law, Tiffany Averitt; special friend, Debbie (Ray) Bastman; and many other dear friends and family.
Besides her parents, Sue was preceded in death by a son, Jim P. Averitt; her brother, Paul Jacquart; aunt, Kay Jacquart; uncle, Bob Jacquart; and her ex-husband, Jim B. Averitt.
Sues family would like to extend a special thank you to all of the workers at Westgate Nursing Home for the support and care they have provided to her over the past several months.
There will be a private family funeral service at Our Lady of Peace Catholic Church per Sues wishes. Interment will be in Riverside Cemetery in Ironwood.
Memorial contributions in her honor may be made to HOPE Animal Shelter, 510 Easy St., Ironwood, MI 49938.
The family has chosen McKevitt-Patrick Funeral Home of Ironwood to honor Sues legacy of life. You can leave a condolence or a tribute at mckevittpatrickfuneralhome.com.
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‘It’s Time To Talk About The Stolen Election,’ Says Wild-Eyed Bill Maher Surrounded By Crates Of Ammo And Emergency Food – The Babylon Bee
Posted: at 4:20 am
LOS ANGELES, CAIn a shocking monologue this past weekend, comedian and political commentator Bill Mahersaid it's time to finally start talking about whether or notthe 2020 election was rigged.
"Good evening fellow patriots, it's time to talk about the stolen election," said the wild-eyed host, who was wearing a MAGA hat and was surrounded by stockpiles of ammunition and emergency food. "I've been doing some research and my eyes have been opened. I think the Deep State may have orchestrated a coup against Donald Trump! And have you really listened to this Ron Paul guy? He really makes a ton of sense! And do you know what else? I'm starting to think gun control will do nothing to reduce gun crime! And by the way, have you seen how the government is spending our money? And have you seen the crap they're teaching in schools? THEY'RE GROOMING KIDS! WE'RE BEING RULED BY A CABAL OF PEDOPHILES! AHHHHHHH!"
According to sources, the crowd sat in stunned silence for a few seconds before someone in the back started a slow clap that spread throughout the audience until everyone was on their feet chanting "BILL! BILL! BILL! BILL!"
Maher says he still identifies as a Liberal andis glad to have finally found the true home of liberal values: conservatism.
The host is reportedly changing the name of his show to Bill's Patriot Hour, where he will rant aboutprogressive insanity, cancel culture, and whether or not Q will finally do what he promised and reinstate President Trump.
You can support Bill's new show by purchasing a high-quality MyPillow using code "BILLMAHER."
In the social justice system, words are considered violence. In New York City, the dedicated detectives who investigate these vicious attacks are members of an elite squad known as the Microaggression Victims Unit. These are their stories.
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'It's Time To Talk About The Stolen Election,' Says Wild-Eyed Bill Maher Surrounded By Crates Of Ammo And Emergency Food - The Babylon Bee
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Athletes of the Week: Losing helps badminton champ HaNeul Jeong-McDonell gain ground – Star Tribune
Posted: at 4:20 am
HaNEUL JEONG-McDONELL
St. Paul Highland Park badminton
Jeong-McDonell learns quickly from her losses.
The Scots senior defeated St. Paul Washington's Cinderella New 21-12, 21-14 to win the singles championship in the badminton state tournament at Edina High School. She was the runner-up in the state tournament in 2021.
"I was overwhelmed and excited," Jeong-McDonell said. "You can learn from your losses. I just kept plugging away."
Jeong-McDonell lost to New the previous week, 10-21, 21-16, 21-16, in the singles final in the St. Paul City Conference championships.
"I knew I could face her again in the state tournament," Jeong-McDonell said. "I worked hard on receiving her high serves. That helped me in the state tournament."
Jeong-McDonell was seeded second behind New entering the event. The previous year she was more of an unknown.
"I wasn't expected to place last year. I surprised myself," Jeong-McDonell said. "This year was a lot of fun."
Northfield lacrosse
The three-year captain is a big reason the Raiders are 9-2 this season. Northfield's leading scorer, he has 42 goals, three more than he scored a year ago, and 20 assists. He has five games of at least five goals. "Spencer is a natural goal scorer who can also be a two-way contributor," Raiders coach Jeff Wright said.
White Bear Lake softball
Barber is 13-2 as a pitcher with a 1.11 ERA while striking out 190 in 101 innings. At the plate, the junior is hitting .446 with 12 home runs and 36 RBI. "Chloe's talent, potential and knowledge of the game make her a special player," Bears coach Kaity Wightman said.
Edina golf
The senior is one of the reasons Edina is ranked No. 1 in the state by the Minnesota Golf Association. Nasby, ranked No. 34 among individuals, shot a 7-under-par 64 in a Lake Conference meet at Wild Marsh Golf Club in Buffalo. "A 64 is a crazy low number for a high school golfer to shoot, and he made it look easy," Edina coach Mike McCollow said.
Bloomington Kennedy lacrosse
The senior has 73 goals on the season, which includes five games of eight or more. She has three 10-goal games in the past two years, helping turn the Eagles program into a winner.
Farmington baseball
The senior first baseman homered in three consecutive games as the Tigers (17-2) extended their winning streak to 15 games. "He continuously finds ways to reach base and help us produce runs," Farmington coach Jon Graff said.
Belle Plaine softball
The sophomore catcher is hitting .559 with 23 runs scored and 37 RBI. She has belted seven of her 13 home runs in May. "Cam works very hard to get better every year," Tigers coach Brent Jaeger said. "She is one of those players every coach would love to have."
RON HAGGSTROM
Nominate an athlete: Send an e-mail with supporting information to preps@startribune.com. Include a photo and a link, if available, to video.
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NSSCL Division Seven: Jake Mills makes history in Cheadle thirds’ weekend win – Stoke-on-Trent Live
Posted: at 4:20 am
Cheadle thirds batsman Jake Mills broke the individual NSSCL Division Seven batting record in his sides victory at Rode Park & Lawton seconds at the weekend.
The previous record was Nigel Sargeants 177 for Oakamoor against Bagnall in 2011 - when it was known as Division Three B - but Mills raced past that landmark.
Mills struck an unbeaten 202 to dominate Cheadles 284-2 from their 40 overs on the road.
Mills faced 149 balls in his innings, hitting 29 fours and three sixes in his record-breaking knock - not the first time he has set a landmark in the league.
He actually holds the overall league highest score record after scoring 262 not out for Cheadle in a 2017 Division Five win against Meakins. That surpassed the 242 scored by James McCarthy for Porthill Park in 2004.
On Saturday, Sam Cliffe (34) and Joe Degg (27) lent support at the other end as Cheadle virtually had the game wrapped up by the halfway stage.
Rode Park & Lawton didnt disgrace themselves in reply as they managed a highly-respectable 168-6 from their allocation.
Thomas Atkinson scored an unbeaten 50, featuring 10 fours, with Cosmos Cupid (33) and Gary Jennison (25) also spending decent time at the crease.
Sam Akram took a couple of wickets for Cheadle as they eased to victory.
Audley thirds had few concerns in beating Wood Lane seconds.
Visitors Audley posted 246-7 on their visit to Megacre, in which Charles Birkin made 46 and Andrew Forster chipped in with 40.
Levi Smith and Andrew Norcup both grabbed a couple of wickets for Wood Lane.
In reply, Matthew Hagan (31), Deane Jervis (27) and Smith (25) shone, but Wood Lane were bundled out for 138.
Thomas Boundy did the damage with 4-26, with Huey Nield capturing 3-13.
Onneley were in good form to win at home against Sandbach seconds.
Set 136 for victory, Onneley seconds had Geoff Hall (32no) and Michael Knowles (31no) to thank primarily for their six-wicket triumph.
But Kyle Knowles (29) and Ash Hall (26) also played their part, despite Paul Jacksons two wickets.
Sandbach had stuck 135-9 on the board earlier on in the afternoon, with Jackson top-scoring with 30.
Evergreen batsman Richard Bowyer also starred with 22 at the top of the oder.
Bradley Hall, Kyle Knowles and Ash Hall shared six of the wickets to fall in the Sandbach innings.
Porthill Park fourths had a productive away-day as they netted the 18 points on offer at Kidsgrove.
Calum Biltons unbeaten 40 was backed up by Chris Tattons 33 and 31 from Harry Stubbs as Porthill Park made fine progress to 184-7. Kane Lowton and Thomas Plant snared a couple of victims apiece.
Chris Highfield (31), James Green (28) and Plant (21) fronted the Grove response, but they were limited to 144-8 at the close.
That was thanks to double strikes from Alex Lockett and Bilton.
Woore seconds won on their visit to Checkley thirds.
Andrew Burton hit 10 fours and one six in his 73 to form the cornerstone of Woores 192-9.
Michael Griffiths weighed in with 34, while Jack Farrington claimed 3-35 for Checkley.
Farrington (32) showcased his all-round ability after tea, with Andrew Eccles chipping in with 25.
But Jake Toppings 3-25, plus a couple of wickets from Lauren Kenvyn, ensured Checkley drew stumps on 120-8.
Audlem cruised to victory in their home meeting with Endon seconds.
Half-centuries from Andy Rothwell and Dave Parkinson were instrumental in Audlems 208-7 from their 40 overs.
Rothwell made 60 and Parkinson added 56, with Callum McIlveen adding late momentum with an unbeaten 38.
Liam Clows 20 was the main contribution in reply, but double strikes from McIlveen, Simon Swift and Ron Paul, saw Endon dismissed for 122.
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Pau Torres agents flying to Manchester this week, Ten Hag confirms he wants Ronaldo to stay Man Utd tra… – The US Sun
Posted: at 4:20 am
Good morning United fans
Anthony Martial is back at Manchester United after Sevilla reportedly rejected the chance to sign him.
United have been urged to sign Norwich ace Max Aarons by Rio Ferdinand.
Ferdinand believes Aarons would have a lot of longevity at United and would prove to be a clever investment.
Duo Alex Telles and Hannibal Mejbri have been named as the two players that were involved in a bust-up at Carrington earlier this month.
SunSport exclusively revealed that twoRed Devils stars had to be pulled apart in shocking scenesfollowing their training ground scrap, and now the men have been named.
Manchester Evening Newsreported that new boss Erik ten Hag is still yet to meet Ralf Rangnick.
And Ten Hag says he is relishing working with former Everton loanee Donny van de Beek again after their time together at Ajax.
And he warned rivals Liverpool and Manchester City he is coming for them.
Ten Hag said: In this moment, I admire them both, Manchester City and Liverpool. They both play really fantastic football, both Liverpool and Man City.
But you will always see an era can come to an end and I am looking forward to battling with them.
Im really looking forward to doing this job at this club with massive history. And we want to restore it to where it belongs.
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Pau Torres agents flying to Manchester this week, Ten Hag confirms he wants Ronaldo to stay Man Utd tra... - The US Sun
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Cool Sunday and to start the week, temps rebound nicely Thursday & Friday – MPR News
Posted: at 4:20 am
This is a great time of year, with colorful blossoms on many trees. Although its cool today, the weather will cooperate with most outdoor plans. A brief passing sprinkle is possible in Minnesota and western Wisconsin.
Sunday afternoon highs will be in the 50s across much of Minnesota and western Wisconsin. A few spots in the Twin Cities metro area and southeastern Minnesota could touch 60 degrees. For reference, our average Twin Cities high temp is 71 degrees this time of year.
Low temps late Sunday night and early Monday morning are forecast to reach the 30s in roughly the northern half of Minnesota plus western Wisconsin:
Forecast low temps late Sunday night/early Monday morning
National Weather Service
When winds are light, the temperature near the ground can be several degrees colder than the official temp which is measured 5 feet above the ground. Frost advisories may be needed overnight in the coldest areas.
You can hear updated weather information for Minnesota and western Wisconsin on the Minnesota Public Radio Newsnetwork, and you can see updated weather info on the MPR Newslive weather blog.
Temperature trends
Monday highs will reach the 60s in most areas, with a few upper 50s in parts of northeastern Minnesota:
Monday forecast highs
National Weather Service
Twin Cities metro area highs are projected to be in the mid 60s Monday and Tuesday, then around 60 degrees on Wednesday, followed by 70 Thursday and mid 70s on Friday.
Wednesday looks like the rainiest day this coming week, but we could also see a few showers late on Tuesday. Check updates.
June outlook
The June temperature outlook from the NWS Climate Prediction Center shows equal chances of above normal or below normal temps for most of Minnesota and western Wisconsin:
June temperature outlook
NWS Climate Prediction Center
Even if our June temps average out close to normal, it will be enjoyable; our average Twin Cities high temp goes from 75 degrees on June 1 to 83 degrees on June 30.
Flood update
Flood warnings (shaded green on the following three maps) continue along several rivers in Minnesota, including the Rainy River Basin of northeastern Minnesota:
Flood warnings are shaded green
National Weather Service
Flood warnings are shaded green
National Weather Service
Flood warnings are shaded green
National Weather Service
Here are details on the Rainy River Basin flood warning in northeastern Minnesota:
Flood Statement National Weather Service Duluth MN 304 PM CDT Sat May 21 2022 MNC071-075-137-252200- /O.CON.KDLH.FA.W.0011.000000T0000Z-220525T2200Z/ /00000.0.RS.000000T0000Z.000000T0000Z.000000T0000Z.OO/ Koochiching MN-Lake MN-St. Louis MN- 304 PM CDT Sat May 21 2022 ...FLOOD WARNING REMAINS IN EFFECT UNTIL 5 PM CDT WEDNESDAY... * WHAT...Flooding caused by rain and snowmelt is occurring. Namakan Lake has already surpassed the level reached in the 2014 flood and is continuing to rise. Rainy Lake is expected to exceed the 2014 level. * WHERE...Portions of north central Minnesota and northeast Minnesota, including the following counties, in north central Minnesota, Koochiching. In northeast Minnesota, Lake and St. Louis. * WHEN...Until 500 PM CDT Wednesday. * IMPACTS...Lake level rises are ongoing. Flooding continues on areas lakes and rivers. Widespread impacts are ongoing for shoreline residents. * ADDITIONAL DETAILS... - At 301 PM CDT, Emergency management reported ongoing flooding across the warned area. - Lake inflows are slowing for Crane Lake, Kabetogama Lake and Namakan Lake. However... inflows still exceed outflows so rises will continue... especially on Rainy Lake. Lake levels on Namakan Lake are expected to rise 6 to 7 inches through May 27th with continued rises thereafter. Namakan Lake inflows are expected to decline but remain high for the remainder of the month. Rainy Lake is expected to rise 12 inches through May 27th. The 2014 level on Rainy Lake will be exceeded early this week and rises will continue at a slower rate beyond the 7 day forecast. Expect minimal rainfall amounts over the next 7 days. - Areas affected include Rainer, Island View, Voyageurs National Park, Crane Lake, Kabetogama Lake and Lake Vermilion. - http://www.weather.gov/dlh/RainyRiverBasin PRECAUTIONARY/PREPAREDNESS ACTIONS... Turn around, don`t drown when encountering flooded roads. Most flood deaths occur in vehicles. Use extreme caution if venturing our on these water bodies as many hazards exist.
And here is more info:
Flooding update for the Rainy River Basin
National Weather Service
You can get updated info on the flood warning areas by clicking on the maps that are posted by the Duluth, Grand Forks, and the Twin Cities NWS offices.
Hydrographs of river levels
Map of river stages on May 22
NOAA/NWS/U.S. Geological Survey
NOAAsAdvanced Hydrologic Prediction Servicesite shows river gauges across our region. You can click on any gauge at that site to get recent and current river levels plus the forecast levels over the next few days.
The Mississippi River at Aitkin had been at moderate flood stage, and has now dropped to minor flood stage:
The Mississippi River at Aitkin, Minnesota
NOAA/NWS/U.S. Geological Survey
The Mississippi River is expected to stay below minor flood stage at St. Paul this week:
The Mississippi River at St. Paul
NOAA/NWS/U.S. Geological Survey
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Originally posted here:
Cool Sunday and to start the week, temps rebound nicely Thursday & Friday - MPR News
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Fireproof "Handmaid’s Tale" edition is up for auction: A "symbol against censorship" – CBS News
Posted: at 3:43 am
A record number of books have been banned or challenged in the U.S. in the last year, part of a push by conservatives torein in discussionof issues that some find distasteful. Now, author Margaret Atwood is responding to the rise in censorship by auctioning a fireproof edition of her novel "The Handmaid's Tale," which ranks among the most frequently banned books in the U.S.
In a video posted onSotheby's sitefor "The Unburnable Book," Atwood is shown with a flamethrower as she takes aim at the edition, which is printed on pages made from heat-resistantCinefoil, sewn together with nickel wire. The flames lick at the book, but the pages remain intact.
"I never thought I'd be trying to burn one of my own books ... and failing," Atwood said in a statement.
The edition is "designed to protect this vital story and stand as a powerful symbol against censorship," the auction site notes.
The auction, which places the expected sale range at $50,000 $100,000, will direct all proceeds to PEN America, a group that advocates for free expression and that plans to use the money to support those efforts. "The Handmaid's Tale," first published in 1985, is a dystopian vision of a future America where women are stripped of their rights and live under a theocracy that prizes them strictly for their reproductive abilities.
Interest in "The Handmaid's Tale" has increased amid a leaked Supreme Court draft opinion that, if finalized, would pave the way for states to severely curtail abortion rights in the U.S. The prospect Roe v. Wade being overturned has sparked observations about the book's prescience and relevance to modern events.
"The Handmaid's Tale" has been among the most challenged publications in America, with the American Library Association (ALA) noting that it has been targeted for "vulgarity and sexual overtones."
Efforts to ban books have surged in the past year, with the ALA finding there were a record 729 challenges to more than almost 1,600 titles in 2021, double the number in 2020.
Atwood said in the statement that her book has been banned "by whole countries, as Portugal and Spain in the days of Salazar and the Francoists, sometimes by school boards, sometimes by libraries." She also expressed hope that society doesn't get to the point of "wholesale book burnings, as in 'Fahrenheit 451'," referring to the Ray Bradbury classic.
More recently, Barnes & Noble has faced pressure from a Virginia lawmaker and a congressional candidate to restrict sales of two books deemed "obscene" to minors without parental consent. The candidate, Tommy Altman, said he is running for Congress to protect freedom, including the right to free speech. One of the books the pair is aiming to restrict is the most challenged book of 2021, the memoir "Gender Queer" by Maia Kobabe.
"To see [Atwood's] classic novel about the dangers of oppression reborn in this innovative, unburnable edition is a timely reminder of what's at stake in the battle against censorship," Penguin Random House CEO Markus Dohle said in a statement.
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Fireproof "Handmaid's Tale" edition is up for auction: A "symbol against censorship" - CBS News
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