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Category Archives: Transhuman News
DNA leads to charges in 6 rapes dating back to 2003
Posted: October 2, 2014 at 7:43 pm
With the aid of DNA evidence, a North Side man has been charged in a string of brutal sexual assaults across Chicago that stretched back to 2003 and included two he allegedly committed with his brother, authorities said Tuesday.
Leondo Joseph, 38, and his brother LB Joseph, 29, appeared in bond court over the weekend, where they were ordered held without bail for their alleged roles in the case which experts said illustrates the potential and the shortcomings of the state's DNA evidence collection and testing.
Women were terrorized and sexually assaulted in their apartments or forced into vehicles by threat of violence in the six attacks, which occurred in the city's Lakeview and Brighton Park neighborhoods and the community areas of North Lawndale and Belmont Cragin, court documents reveal.
Leondo Joseph, arrested Saturday night at his home in the 2500 block of North Halsted Street, is charged in all six attacks, according to records. LB Joseph is charged in the two most recent attacks in 2011 and 2012. Both brothers also face aggravated kidnapping charges.
Chicago detectives linked the brothers to the assaults through Illinois State Police crime lab examinations of all six assaults, prosecutors said in court at the bond hearing. In addition, some victims have identified the brothers, and Leondo Joseph gave statements regarding some of the cases, prosecutors said.
The number of years covered by the assaults nine was noteworthy, though victim's advocates point out that rapists, including in acquaintance assaults, are often repeat offenders.
But the experts also pointed to the fact that Chicago police were not notified by the crime lab until this year that the 2012 case was linked to the other five attacks, which was critical information because in the 2012 attack, Chicago police stopped a vehicle carrying the two brothers, though they were not charged.
"With a stranger case, DNA has a different kind of function, to identify and to connect cases to each other," said Sharmili Majmudar, executive director of Rape Victim Advocates. "Then the question becomes are we allocating enough resources to address and process the DNA we do receive through these kits in keeping with the trust the survivors are placing in the system.
"The crime lab is not resourced fully. There is definitely not a 'Law and Order: SVU' turnaround," she said, referring to the police procedural TV drama. "It is nowhere near what people expect."
Officials at the crime lab were not available Tuesday afternoon to answer questions about the case. The turnaround time at the lab has long been a concern of police, who rely on the work-ups.
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DNA leads to charges in 6 rapes dating back to 2003
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Twice the DNA yield in less time
Posted: at 7:43 pm
PUBLIC RELEASE DATE:
2-Oct-2014
Contact: Beth Parada apps@botany.org American Journal of Botany @Botanical_
Molecular studies of plants often depend on high-quantity and high-quality DNA extractions. This can be quite difficult in plants, however, due to a diversity of compounds and physical properties found in plants. "Tannins, tough fibrous material, and/or secondary compounds can interfere with DNA isolation," explains Dr. Thomas Givnish, principal investigator of a new study published by Jackson Moeller et al. in the October issue of Applications in Plant Sciences (available for free viewing at http://www.bioone.org/doi/pdf/10.3732/apps.1400048).
This is further complicated by the fact that different plant groups have different compounds and, therefore, different DNA extraction methods may be necessary to obtain sufficient high-molecular-weight DNA depending on the species you are working with.
Moeller, Givnish, and their colleagues at the University of WisconsinMadison evaluated a new DNA isolation technique and compared it to two often-used DNA extraction methods for plant tissues. The new technique is based on MagnaCel paramagnetic cellulose particles (PMC), and was originally designed and developed for forensic applications in which only minute amounts of DNA are present.
The utility of the PMC method was compared with both a silica column technique (DNeasy Plant Mini Kit) and the cetyltrimethylammonium bromide (CTAB) method. This comparison was done across a wide range of flowering plants, from lilies to sunflowers. The PMC method was found to be more efficient and, unlike the CTAB technique, does not involve the use of hazardous chemicals. Most important, DNA yield from PMC was double that of either DNeasy or CTAB.
"We were eager to explore techniques that might reduce the amount of time and labor required to obtain genomic DNA reliably from leaf samples from taxa with a very wide range of leaf chemistries," says Givnish.
Statistical analyses were conducted to test for significant differences in quality and quantity of DNA obtained between extraction techniques and the different species tested. "We feel this study provides a telling test of the efficacy of paramagnetic cellulose DNA isolation relative to other techniques. We found that Promega's MagnaCel DNA extraction kit substantially outperformed CTAB and DNeasy extractionsproviding an average of twice the DNA yield across 25 plant species in 21 families and producing more consistent DNA purity based on absorbance ratios at 260 nm vs. 280 nm and 230 nm," explains Givnish. "The advantage of the MagnaCel approach is especially high at low DNA concentrations."
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Twice the DNA yield in less time
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DNA suggests humanity has more mothers than fathers
Posted: at 7:43 pm
LEIPZIG, Germany, Oct. 1 (UPI) -- Throughout human history monogamy has been a sexual philosophy largely eschewed by men, yet demanded of women. This was especially so for men of early human societies, who preferred the company of numerous wives.
We know this much thanks to the research skills of several generations of anthropologists. And now, this understanding has been confirmed by DNA analysis and the work of researchers in the field of human evolution. As a recent study of human DNA revealed, humanity has absorbed the genetics of many more mothers than fathers -- further proof the men of early societies fathered children with multiple women.
"[Historically] more of the women were reproducing than the men," Mark Stoneking, a biological anthropologist at Germany's Max Planck Institute for Evolutionary Anthropology, told Live Science. "This often happens in human societies, because not all men are able to afford wives, or sometimes a few men will have many wives."
Stoneking and his colleagues used a new technique for observing the variances within the paternally inherited Y chromosome, passed down from father to son, and the mitochondrial DNA, the genes inherited from mothers. After collecting DNA samples of 623 males sourced from 51 populations around the world, including Australian, European, and American populations, researchers were able to show that females not only reproduced more frequently than males, but that women also migrated more often.
Because women of early societies often traveled for marriages, moving in with their husbands in a faraway village, females spread their DNA around geographically, resulting in fewer variances from population to population. Men and their sons, on the other hand, tended to stay put, enabling male DNA to remain more distinct from place to place.
Researchers hope these new DNA analysis techniques can continue to be used to learn more about the history of humanity's fathers and mothers.
The study was published last week in the journal Investigative Genetics.
2014 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
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DNA suggests humanity has more mothers than fathers
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BrianLehrer.tv: Soldier Debts; Bike Crash; Ashkenazi Genome; NY101 – Video
Posted: at 7:43 pm
BrianLehrer.tv: Soldier Debts; Bike Crash; Ashkenazi Genome; NY101
It #39;s deep debt and wage garnishment for soldiers who buy into deals at discount stores near military bases. Paul Kiel, an investigative reporter with ProPublica, explains. Then, following...
By: cunytv75
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BrianLehrer.tv: Soldier Debts; Bike Crash; Ashkenazi Genome; NY101 - Video
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Ebola genome browser now online to aid researchers' response to crisis
Posted: at 7:43 pm
PUBLIC RELEASE DATE:
1-Oct-2014
Contact: Guy Lasnier lasnier@ucsc.edu 831-459-2955 University of California - Santa Cruz @ucsc
The UC Santa Cruz Genomics Institute late Tuesday (September 30) released a new Ebola genome browser to assist global efforts to develop a vaccine and antiserum to help stop the spread of the Ebola virus.
The team led by University of California, Santa Cruz researcher Jim Kent worked around the clock for the past week, communicating with international partners to gather and present the most current data. The Ebola virus browser aligns five strains of Ebola with two strains of the related Marburg virus. Within these strains, Kent and other members of the UC Santa Cruz Genome Browser team have aligned 148 individual viral genomes, including 102 from the current West Africa outbreak.
UC Santa Cruz has established the UCSC Ebola Genome Portal, with links to the new Ebola genome browser as well as links to all the relevant scientific literature on the virus.
"Ebola has been one of my biggest fears ever since I learned about it in my first microbiology class in 1997," said Kent, who 14 years ago created the first working draft of the human genome. "We need a heroic worldwide effort to contain Ebola. Making an informatics resource like the genome browser for Ebola researchers is the least we could do."
Scientists around the world can access the open-source browser to compare genetic changes in the virus genome and areas where it remains the same. The browser allows scientists and researchers from drug companies, other universities, and governments to study the virus and its genomic changes as they seek a solution to halt the epidemic.
The release of the new Ebola genome browser comes as the U.S. Centers for Disease Control and Prevention Tuesday confirmed the first case of Ebola in the United States.
The Ebola browser was started shortly after a phone conversation between Kent and his sister, an epidemiologist at the CDC, who spoke of how she and her staff were consumed with Ebola research in the face of the escalating crisis. UC Santa Cruz Professor Phil Berman, an HIV specialist, had also asked Kent for help with his efforts in developing a vaccine for Ebola.
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Ebola genome browser now online to aid researchers' response to crisis
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Ebola genome browser now online
Posted: at 7:43 pm
The UC Santa Cruz Genomics Institute has released a new Ebola genome browser to assist global efforts to develop a vaccine and antiserum to help stop the spread of the Ebola virus.
The team led by University of California, Santa Cruz researcher Jim Kent worked around the clock for the past week, communicating with international partners to gather and present the most current data. The Ebola virus browser aligns five strains of Ebola with two strains of the related Marburg virus. Within these strains, Kent and other members of the UC Santa Cruz Genome Browser team have aligned 148 individual viral genomes, including 102 from the current West Africa outbreak.
UC Santa Cruz has established the UCSC Ebola Genome Portal, with links to the new Ebola genome browser as well as links to all the relevant scientific literature on the virus.
Ebola has been one of my biggest fears ever since I learned about it in my first microbiology class in 1997," said Kent, who 14 years ago created the first working draft of the human genome. "We need a heroic worldwide effort to contain Ebola. Making an informatics resource like the genome browser for Ebola researchers is the least we could do.
Scientists around the world can access the open-source browser to compare genetic changes in the virus genome and areas where it remains the same. The browser allows scientists and researchers from drug companies, other universities, and governments to study the virus and its genomic changes as they seek a solution to halt the epidemic.
The release of the new Ebola genome browser comes as the U.S. Centers for Disease Control and Prevention Tuesday confirmed the first case of Ebola in the United States.
The Ebola browser was started shortly after a phone conversation between Kent and his sister, an epidemiologist at the CDC, who spoke of how she and her staff were consumed with Ebola research in the face of the escalating crisis. UC Santa Cruz Professor Phil Berman, an HIV specialist, had also asked Kent for help with his efforts in developing a vaccine for Ebola.
Kent asked his supervisor, UC Santa Cruz bioinformatics researcher David Haussler, if he could divert his team to Ebola work. Haussler replied with an enthusiastic affirmative, and they pulled together a team of UC Santa Cruz bioinformatics scientists that, within a week, was able to create a fully functional Ebola genome browser.
"The incredible speed with which this group was able to assemble all the genetic information about Ebola and make it available to the world shows what a great team Jim Kent has assembled," Haussler said.
In June 2000, Kent and Haussler released the first working draft of the human genome sequence on the web. Two months later, Kent developed the UCSC Genome Browser, which has become an essential resource to biomedical science.
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Genomics
Posted: at 7:43 pm
DEFINITION of 'Genomics'
The study of the genome, which is the complete set of the genetic material or DNA present in an organism. Genomics studies all genes and their inter relationships in an organism, so as to identify their combined influence on its growth and development. The field of genomics attracted worldwide attention in the late 1990s with the race to map the human genome. The Human Genome Project (HGP), completed in April 2003, made available for the first time the complete genetic blueprint of a human being. Genomics has already made huge strides in better health care by enabling researchers to develop improved diagnostics and more effective therapies, while providing better decision-making tools for patients and health care providers.
The human genome is a very complex entity containing huge amounts of information. DNA molecules are made of two twisting, paired strands often called a double helix and each strand consists of four chemical units called nucleotide bases adenine (A), thymine (T), guanine (G) and cytosine (C). Bases on opposite strands pair in a very specific manner for example, an A always pairs with a T, and a C always pairs with a G. The order of this genetic alphabet determines the meaning of the information encoded in that part of the DNA molecule.
The human genome contains about 3 billion of these base pairs. Genome sequencing involved figuring out the exact order of all 3 billion of these DNA nucleotides, a feat which would not have been possible without massive amounts of computing power.
The Human Genome Project, which was formally initiated by the U.S. Department of Energy and National Institutes of Health in 1988, was successfully completed in April 2003. It was designed to create a resource that could be used for extensive biomedical studies, such as looking for the genetic variations that increase the risk of specific diseases. A study released in June 2013 reported that the $14.5-billion investment in HGP by the U.S. had paid off more than 60-fold in new jobs, drugs and a booming genetics industry, with a total economic impact of $966 billion.
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Nose knows when death is imminent, smell study suggests
Posted: at 7:43 pm
Sense of smell is the canary in the coalmine of human health, say U.S. researchers, who have found that difficulty identifying particular scents is linked to an increased risk of death.
A new study of more than 3,000 people found that participants with the poorest sense of smell, also called olfactory dysfunction, had a risk of death three times greater than those with a normal sense of smell.
That was even after taking into account other factors, including age, gender, nutrition, mental health status, a history of smoking or alcohol abuse, and other health issues.
Olfactory dysfunction was an independent risk factor for death, stronger than several common causes of death, such as heart failure, lung disease and cancer, the researchers concluded, indicating that this evolutionarily ancient special sense may signal a key mechanism that affects human longevity.
The study was published Wednesday in the journal PLOS One.
For their research, scientists at the University of Chicago studied 3,005 adults between the ages of 57 and 85.
The participants were each asked to identify five scents that had been placed in felt-tip pens: rose, leather, orange, fish and peppermint.
The researchers followed up with the participants five years later.
They found that 39 per cent of older participants with olfactory dysfunction were dead, compared to just 10 per cent who had a normal sense of smell.
The researchers say that the sense of smell is unique compared to other senses in that it relies on stem cell turnover to function properly. A deteriorating sense of smell may indicate a break down in the cell regeneration process, either due to age or the effect of ongoing exposure to environmental toxins.
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Nose knows when death is imminent, smell study suggests
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Life-extending drugs take humanity into new territory
Posted: at 7:43 pm
The reasons to be cautious about taking longevity drugs probably wont hold us back. They will just be too tempting to turn down
BENJAMIN FRANKLIN once wrote that "in this world nothing can be said to be certain, except death and taxes". That has not deterred a good many people usually wealthy, ageing men from trying to dodge one, or the other, or both.
Tax avoidance is one thing, but as yet nobody has achieved immortality, or even modest life extension beyond the apparent upper limit of about 120 years. The well of human optimism runs deep, though, and on a fairly regular basis somebody with deep pockets unveils ambitious plans to tackle or end ageing. The latest is Google, which a year ago announced plans to get into the longevity business with a biotech start-up called Calico.
It is easy to be cynical about such ventures. Around a decade ago there was a similar flurry of interest from Silicon Valley as the backers of the Ansari X Prize fresh from awarding $10 million to aviation pioneer Burt Rutan for putting a private vehicle into space announced plans for an institute to solve the "problem" of death. The science of ageing was sufficiently advanced, it claimed, for us to be able to intervene to slow or even stop it.
Like so many quests for immortality, this one proved quixotic. But one of its main goals to extend human lifespan by reducing the rate of ageing appears to have unexpectedly been achieved (see "Everyday drugs could give extra years of life"). A number of drugs that were developed for other purposes seem to have the happy side effect of increasing lifespan in animals. Some researchers who work on them are now so convinced of their potential to add about 10 years to a human life that they have started self-medicating.
The appropriate warnings need to be wheeled out: the history of life-extension research is virtually defined by cycles of hype and disappointment. The evidence is little more than suggestive and the side effects unknown. But if the drugs work as the researchers believe by slowing the ageing process itself humanity is about to enter new territory.
There will be many scientific and regulatory hoops to jump through the inevitable rise of a black market notwithstanding. There are also important political and ethical issues to chew over.
A critical one concerns overpopulation: if everybody alive today added a decade to their life expectancy, the world's already bloated population would inevitably rise even further. Quality of life is another concern: life extension could lead to a nightmarish "nursing home world" full of decrepit people who need to be supported by an ever-dwindling supply of youngsters. Yet another is inequality: drugs cost money, so could exacerbate the divide between haves and have-nots.
These are important questions. But it is hard to see them standing in the way. The temptation of extending our lives is too great.
It need not lead to a dystopian future. There has long been a strand of thought within gerontology that rejects radical life extension or immortality in favour of more modest goals. If we could slow ageing by about seven years, the argument goes, people would live longer, healthier lives, and then decline and die quickly with minimal decrepitude. The effects on population would be negligible, and the drugs are as cheap as aspirin and statins.
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Life-extending drugs take humanity into new territory
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Sense of smell may predict longevity
Posted: at 7:43 pm
Researchers in the US have found that olfactory dysfunction was better at predicting mortality than a diagnosis of heart failure, cancer or lung disease. Photo: Supplied
Smelly socks have never seemed so life-affirming. According to a study published in scientific journalPLOS One, olfactory dysfunction - a weakening sense of smell - is a strikingly good indicator of imminent death.
No, a bad sense of smell isn't fatal - and it probably isn't the symptom of some insidious illness. But based on this new study, it seems that our noses may act as canaries in the coal mines of our bodies.
When things are amiss, and systems are shutting down, the researchers suggest, our sense of smell might be one of the best outward indicators.
Aromatic? A vintage leather armchair.
Researchers in the US tested a nationally representative sample of 3005 men and women aged 57 to 85 on their ability to identify five smells: rose, leather, orange, fish and peppermint. The study appearsonline in PLOS One.
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They controlled for many factors age, sex, socioeconomic status, smoking, alcohol intake, education, body mass index, race, hypertension, diabetes, heart attack, emphysema, stroke and diet.
Five years later, the researchers found that 430 of the original participants had died.
Thirty-nine per cent of study subjects who failed a simple smelling test died within five years, compared with 19 per cent of those with moderate smell loss and just 10 per cent of those with a healthy sense of smell, PLOS ONE reported.
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