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Category Archives: Transhuman News

DNA reveals world's most famous sea dog was infact male

Posted: October 19, 2014 at 8:47 pm

A DNA discovery has overturned an ancient mystery and proved that the world's most famous sea dog was in fact male.

Hatch, the unfortunate hound that went down with the Mary Rose 500 years ago, was originally thought to be the only female on board the ship.

The poor pooch went down with the ship and was named after divers discovered his remains near the hatch entrance to the carpenter's cabin.

Four years ago the dog's remains went on display at the Mary Rose Museum in Portsmouth, along with 19,000 objects from Henry VIII's ship, and became a popular tourist attraction.

But now test results published in the Forensic Science International journal show that not only was Hatch in fact a boy, he shared characteristics with the modern breed of Jack Russell.

Maritime archaeologist Alex Hildred told the Independent on Sunday: Genomic DNA extraction is something that we have only recently been able to use in amplifying ancient DNA.

It can give us the sex, colourings, coat and regressive genes, and confirm that Hatch is in fact a boy dog.

The testing was carried out by dental students at King's College, who analysed information taken from one of the dog's teeth.

Hatch was brought on board as a ratter because at the time, sailors believed cats brought bad luck.

Tudor sailors also thought that female members of crew brought bad luck to a vessel.

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DNA reveals world's most famous sea dog was infact male

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Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals

Posted: at 8:47 pm

7 hours ago

DNA has garnered attention for its potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, biology, and more. Researchers have been working to master the ability to coax DNA molecules to self assemble into the precise shapes and sizes needed in order to fully realize these nanotechnology dreams.

For the last 20 years, scientists have tried to design large DNA crystals with precisely prescribed depth and complex features a design quest just fulfilled by a team at Harvard's Wyss Institute for Biologically Inspired Engineering. The team built 32 DNA crystals with precisely-defined depth and an assortment of sophisticated three-dimensional (3D) features, an advance reported in Nature Chemistry.

The team used their "DNA-brick self-assembly" method, which was first unveiled in a 2012 Science publication when they created more than 100 3D complex nanostructures about the size of viruses. The newly-achieved periodic crystal structures are more than 1000 times larger than those discrete DNA brick structures, sizing up closer to a speck of dust, which is actually quite large in the world of DNA nanotechnology.

"We are very pleased that our DNA brick approach has solved this challenge," said senior author and Wyss Institute Core Faculty member Peng Yin, Ph.D., who is also an Associate Professor of Systems Biology at Harvard Medical School, "and we were actually surprised by how well it works."

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Scientists have struggled to crystallize complex 3D DNA nanostructures using more conventional self-assembly methods. The risk of error tends to increase with the complexity of the structural repeating units and the size of the DNA crystal to be assembled.

The DNA brick method uses short, synthetic strands of DNA that work like interlocking Lego bricks to build complex structures. Structures are first designed using a computer model of a molecular cube, which becomes a master canvas. Each brick is added or removed independently from the 3D master canvas to arrive at the desired shape and then the design is put into action: the DNA strands that would match up to achieve the desired structure are mixed together and self assemble to achieve the designed crystal structures.

"Therein lies the key distinguishing feature of our design strategyits modularity," said co-lead author Yonggang Ke, Ph.D., formerly a Wyss Institute Postdoctoral Fellow and now an assistant professor at the Georgia Institute of Technology and Emory University. "The ability to simply add or remove pieces from the master canvas makes it easy to create virtually any design."

The modularity also makes it relatively easy to precisely define the crystal depth. "This is the first time anyone has demonstrated the ability to rationally design crystal depth with nanometer precision, up to 80 nm in this study," Ke said. In contrast, previous two-dimensional DNA lattices are typically single-layer structures with only 2 nm depth.

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Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals

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How a Wiki Is Keeping Direct-to-Consumer Genetics Alive

Posted: at 8:46 pm

When Meg DeBoe decided to tap her Christmas fund to order a $99 consumer DNA test from 23andMe last year, she was disappointed: it arrived with no information on what her genes said about her chance of developing Alzheimers and heart disease. The report only delved into her genetic genealogy, possible relatives, and ethnic roots.

Thats because just a month earlier, in November 2013, the Food and Drug Administration had cracked down on 23andMe. The direct-to-consumer gene testing companys popular DNA health reports and slick TV ads were illegal, it said, since theyd never been cleared by the agency.

But DeBoe, a mommy blogger and author of childrens books, found a way to get the health information she wanted anyway. Using a low-budget Web service called Promethease, she paid $5 to upload her raw 23andMe data. Within a few minutes she was looking into a report with entries dividing her genes into Bad news and Good news.

As tens of thousands of others seek similar information about their genetic disposition, they are loading their DNA data into several little-known websites like Promethease that have become, by default, the largest purveyors of consumer genetic health services in the United Statesand the next possible targets for nervous regulators.

After the FDA crackdown, consumers are trading information on where to learn about their genes. Dont let the man stop you, said one.

Promethease was created by a tiny, two-man company run as a side project by Greg Lennon, a geneticist based in Maryland, and Mike Cariaso, a computer programmer. It works by comparing a persons DNA data with entries in SNPedia, a sprawling public wiki on human genetics that the pair created eight years ago and run with the help of a few dozen volunteer editors. Lennon says Promethease is being used to build as many as 500 gene reports a day.

Many people are arriving from directly from 23andMe. After its health reports were blocked, consumers complained angrily about the FDA on the companys Facebook page, where they also uploaded links to the Promethease website, calling it a workaround, a way to get exhaustive medical info in reports that are similar, but not as pretty. The mood was one of civil disobedience. Dont let the man stop you from getting genotyped, wrote one.

The FDA is being cautious with personal genomics because although DNA data is easy to gather, its medical meaning is less certain.

Consumer DNA tests determine which common versions of the 23,000 human genes make up your individual genotype. As science links these variants to disease risk, the idea has been that genotypes could predict your chance of getting cancer or heart disease, or losing your eyesight. But predicting risk is tricky. Most genes dont say anything decisive about you. And if they do, you might well wish for a doctor at your side when you find out. I dont believe that this kind of risk assessment is mature enough to be a consumer product yet, says David Mittelman, chief scientific officer of Gene by Gene, a genetic laboratory that performs tests.

In barring 23andMes health reports, the FDA also cited the danger that erroneous interpretations of gene data could lead someone to seek out unnecessary surgery or take a drug overdose. Critics of the decision said it had more to do with questions about whether consumers should have the right to get genetic facts without going through a doctor. Its an almost philosophical issue about how medicine is going to be delivered, says Stuart Kim, a professor at Stanford University who helped developed a DNA interpretation site called Interpretome as part of a class he teaches on genetics. Is it going to be concentrated by medical associations, or out there on the Internet so people can interact?

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How a Wiki Is Keeping Direct-to-Consumer Genetics Alive

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psoriasis treated by Dr. Rajesh Khandelwal at Astha clinic (best treatment for psoriasis in India) – Video

Posted: at 8:46 pm


psoriasis treated by Dr. Rajesh Khandelwal at Astha clinic (best treatment for psoriasis in India)
Visit our official site at http://www.asthaclinic.com/ like us on Facebook https://www.facebook.com/AsthaClinicajmer follow us on twitter https://twitter.com/asthaclinic.

By: Dr Rajesh Khandelwal

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Yellow mustard for leg cramps and psoriasis

Posted: at 8:46 pm

Q: My husband is disabled by osteoarthritis and psoriatic arthritis. He experienced frequent muscle cramping and was eating extra yellow mustard for relief.

His psoriasis was treated for years by a dermatologist. After a few weeks of taking large amounts of mustard, he noticed his psoriasis was greatly improved.

After his muscles stopped cramping, he stopped eating mustard. His psoriasis started returning. He has now resumed taking mustard this time for psoriasis.

A: Many readers have reported that a teaspoon or two of yellow mustard eases leg cramps, but you are the first to suggest that this condiment might be helpful for psoriasis.

Your story led us to do some digging in the medical literature. A mouse study published in China demonstrated that when mustard seed was fed to rodents, it suppressed psoriasislike inflammation (Journal of Southern Medical University, September 2013). Japanese scientists concluded that the results of their research provide a basis for mustard seed to be used as a promising intervention for psoriasis in the future (Journal of Dermatology, July 2013).

Your husbands experiment with mustard appears to confirm the preliminary research carried out in animals. Thanks for sharing his experience. Perhaps others will benefit from his discovery.

Q: Your column mentioned using pineapple or banana skin as a topical treatment for plantar warts. The treatment of choice (unfortunately not well known among family doctors or even dermatologists) may be the daily topical application of vitamin A.

Vitamin A can be bought in capsules in any drugstore. Puncture a capsule of the vitamin with a sharp needle. Each day, squeeze a drop or two of the vitamin A oil out of the capsule onto the wart and rub it in well.

Dr. Robert Garry reported 100 percent success within five months in 50 consecutive patients (New England Journal of Medicine, Oct. 14, 2004). I likewise had success with this treatment for a very stubborn plantar wart, although mine required applying the vitamin twice a day to get results.

No side effects have been reported. It just requires stubborn persistence.

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Yellow mustard for leg cramps and psoriasis

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New Clues: Whole-Gene Scan Analyzes Mystery Illnesses

Posted: at 8:45 pm

A new kind of genetic test that analyzes all of a persons genes can provide a diagnosis about a quarter of the time for patients whose conditions have baffled doctors, scientists reported Saturday. And for young children with mysterious developmental delays, the test gives a diagnosis more than 40 percent of the time.

The test is called whole-exome sequencing, and it looks at all 20,000 or so genes in the human body. Its not a whole genome sequence because it leaves out DNA thats not classified as a gene. But such tests provide a good map of the so-called protein coding sequences.

It was a relief for Audrey Lapidus of Los Angeles, whose baby son Calvin seemed just fine at first. But at 6 months, an osteopath suggested genetic testing. She said he had some very interesting facial features, Lapidus told NBC News. Other pediatricians rejected the notion.

But then he just wasnt hitting the milestones, she said. He wasnt sitting up or rolling over.

Deep down, I knew something was wrong."

Still, pediatricians and friends alike reassured her. A basic genetic panel came back clear.

Everyone wants to tell you about their nephew who didnt walk until he was 2 and he graduated from Harvard, Lapidus said. I was holding on to those stories.

At the same time, she continued to visit geneticists and neurologists. Deep down, I knew something was wrong, she said.

Calvin became the first child at UCLA to get a whole-exome genetic test at UCLA, in 2012. When it came back, it showed Calvin had Pitt-Hopkins Syndrome, a rare genetic disorder affecting only 250 children worldwide.

Its caused by a single mutation on one gene found on chromosome 18. It causes developmental delays, seizures and, as Calvins osteopath suspected, distinctive facial features, such as thin eyebrows and sunken eyes. Children often never learn to speak or walk without help.

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Free: Censorship Beep – NI Massive (Lulz) – Video

Posted: at 8:45 pm


Free: Censorship Beep - NI Massive (Lulz)
Download Patch: http://adfoc.us/24435448230970.

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Politicking: Ron Paul Blasts ‘Deeply Flawed’ U.S. Foreign Policy – Video

Posted: at 8:44 pm


Politicking: Ron Paul Blasts #39;Deeply Flawed #39; U.S. Foreign Policy
Former Republican congressman three-time presidential candidate Ron Paul tells Larry how he #39;d handle ISIS why he thinks U.S. Foreign Policy is to blame for the group #39;s rise. Plus, he opens...

By: RT America

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Politicking: Ron Paul Blasts 'Deeply Flawed' U.S. Foreign Policy - Video

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CONNOLLY: Come Rand soon

Posted: at 8:44 pm

Rand Paul represents a new breed of Libertarian who might rejuvenate the GOP by John Connolly | Sep 25 2014 | 09/25/14 12:55am

Rand Paul is perhaps the most intriguing potential 2016 presidential candidate. Rand is not his father committed libertarian Ron Paul, who developed a passionate but ultimately small movement of devoted followers and he seems to have largely escaped the lazy media narrative that he is just like his dad. Like his father, Paul brings unorthodox Republican policy positions onto the national stage. Unlike his father, he may have the mainstream appeal to pull off a Republican presidential primary victory, at the very least. According to a July poll, he leads all other potential Republican candidates in New Hampshire, and is tied for the lead in Iowa.

Rand Paul has the potential to change the Republican Party. Even if he does not win the Republican presidential primary, the ideas he brings to the table might inspire policy shifts among Republican voters and politicians. It is too early to tell whether Pauls flirtation with alternative positions will pay off, so he might be tempted to temper his platform in order to appeal to the traditional Republican primary voter. But doing so would be a grave mistake for the future of the party, as it is crucial that Republicans have substantive dialogue over hot-button issues such as mandatory minimum sentences for drug crimes and Americas role in the international community. (Whether or not Pauls policy suggestions are actually good ones is up for debate. I find many of them to be dubious.)

Paul brings the most diverse platform to the 2016 Republican field. Like practically all of his Republican colleagues in the Senate, he is a budget hawk, supporting deep cuts in government spending. He is also a committed social conservative, supporting a definition of marriage as between one man and one woman, and opposing abortion in all cases, including rape or incest. This is par for the course among potential Republican candidates.

But his penchant for tackling issues not traditionally addressed by Republicans distinguishes him from his prospective primary peers. For instance, Paul has compared the War on Drugs to Jim Crow legislation in its effect on African-American men, pointing out that mandatory minimum sentencing laws do not lead to the arrests of drug kingpins, but rather, to the incarceration and often, the disenfranchisement of thousands of low-level drug dealers. Whats more, Paul has partnered with Democratic Senators Patrick Leahy and Chris Murphy to tackle this issue, a stroke of bipartisanship that few of his Republican colleagues have matched.

Paul most notably differs from his Republican colleagues on issues of the military and national defense. He has called for sweeping defense cuts, opposed the PATRIOT Act, and has proposed that the United States eliminate foreign aid. He has not gone as far as his father, who once declared the United States should eliminate all military bases on foreign soil, but he has stood up for libertarian conservatives who do not view the Iraq War as a quintessentially conservative approach to foreign policy. In an April editorial for National Review, Paul suggests neo-conservatism must be tempered with a dash of libertarianism, in recognition of governments inability to remake the world in its precise preferred image. William Buckley himself, one of the intellectual godfathers of modern conservatism, decried the decision to invade Iraq. As Jeffrey Hart wrote in a 2008 column, Buckley thought the conservative movement had committed intellectual suicide by supporting the war with almost no dissent. If real foreign policy discourse among conservatives is dead, then perhaps Rand Paul can help revive it.

If nothing else, Rand Paul brings a breath of fresh air to a Republican Party that desperately needs it. My hope is that Paul will continue to speak out on issues not ordinarily broached by Republicans, in addition to advocating for a more limited view of foreign policy than the brand practiced under both the Bush and Obama Administrations. I say it is my hope because evidence has suggested, in recent days, that Paul may be reshaping his foreign policy stance to be more consistent with the Republican platform of the last ten years. As the Wall Street Journal pointed out, Paul has backed airstrikes against Islamic militants in Syria and Iraq, bringing him more in line with the GOP mainstream.

A shift to the center might make him more appealing to the average Republican voter, but Paul should be careful not to lose his distinctiveness in the process. What makes Paul intriguing is his willingness to buck party lines, to reach out to minorities through his condemnation of mandatory minimums, and to hold a foreign policy position several rungs to the left of Hillary Clinton and other prominent Democrats. He has the power to start a worthwhile dialogue within the Republican Party. It is my hope that he does not throw this away.

John Connolly is an Opinion Columnist for The Cavalier Daily. His columns run bi-weekly on Thursdays.

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Libertarianism and Derk Pereboom. Summer school "Free will and Moral responsibility". Part two – Video

Posted: at 8:44 pm


Libertarianism and Derk Pereboom. Summer school "Free will and Moral responsibility". Part two

By: Moscow Center for Consciousness Studies

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