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Category Archives: Transhuman News

Ancient Europeans intolerant to lactose for 5,000 years after they adopted agriculture

Posted: October 22, 2014 at 1:44 am

By analysing DNA extracted from the petrous bones of skulls of ancient Europeans, scientists have identified that these peoples remained intolerant to lactose (natural sugar in the milk of mammals) for 5,000 years after they adopted agricultural practices and 4,000 years after the onset of cheese-making among Central European Neolithic farmers.

The findings published online in the scientific journal Nature Communications (21 Oct) also suggest that major technological transitions in Central Europe between the Neolithic, Bronze Age and Iron Age were also associated with major changes in the genetics of these populations.

For the study, the international team of scientists examined nuclear ancient DNA extracted from thirteen individuals from burials from archaeological sites located in the Great Hungarian Plain, an area known to have been at the crossroads of major cultural transformations that shaped European prehistory. The skeletons sampled date from 5,700 BC (Early Neolithic) to 800 BC (Iron Age).

It took several years of experimentation with different bones of varying density and DNA preservation for the scientists to discover that the inner ear region of the petrous bone in the skull, which is the hardest bone and well protected from damage, is ideal for ancient DNA analysis in humans and any other mammals.

According to Professor Ron Pinhasi from the UCD Earth Institute and UCD School of Archaeology, University College Dublin, the joint senior author on the paper, "the high percentage DNA yield from the petrous bones exceeded those from other bones by up to 183-fold. This gave us anywhere between 12% and almost 90% human DNA in our samples compared to somewhere between 0% and 20% obtained from teeth, fingers and rib bones."

For the first time, these exceptionally high percentage DNA yields from ancient remains made it possible for scientists to systematically analyse a series of skeletons from the same region and check for known genetic markers including lactose intolerance.

"Our findings show progression towards lighter skin pigmentation as hunter and gatherers and non-local farmers intermarried, but surprisingly no presence of increased lactose persistence or tolerance to lactose" adds Professor Pinhasi.

"This means that these ancient Europeans would have had domesticated animals like cows, goats and sheep, but they would not yet have genetically developed a tolerance for drinking large quantities of milk from mammals," he says.

According to Professor Dan Bradley from the Smurfit Institute of Genetics, Trinity College Dublin, co-senior author on the paper, "our results also imply that the great changes in prehistoric technology including the adoption of farming, followed by the first use of the hard metals, bronze and then iron, were each associated with the substantial influx of new people. We can no longer believe these fundamental innovations were simply absorbed by existing populations in a sort of cultural osmosis."

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Asian Carp DNA Found in the Fox River

Posted: at 1:44 am

Green Bay (WFRV) The Wisconsin Department of Natural Resouces (DNR) reports Asian Carp DNA has been found in the Fox River in Green Bay. Even though the DNA was found in the river, that does not mean the invasive species is in the river.

Here is the news release from the WI DNR:

State pursues additional testing after silver carp environmental DNA detected in Lower Fox River

Weekly News Article Published: October 21, 2014 by the Central Office MADISON -- Continued surveillance to protect Wisconsin waters against invasive species has turned up a single positive environmental DNA, or eDNA, sample for silver carp in the Lower Fox River.

The sample, among hundreds taken statewide in recent months, does not necessarily signal the presence of live fish. To determine the source of the eDNA found in the river, the Wisconsin Department of Natural Resources is collaborating with the U.S. Fish and Wildlife Service and has asked the federal agency for its help to collect additional samples from the Fox River in the next two weeks.

Asian carp pose significant ecological and economic threats to the Great Lakes region and its fishery because they eat voraciously and compete directly with valuable native fish for food.

"The tests for environmental DNA are extremely sensitive and can detect genetic material shed in mucus or excrement from fish as well as from birds that have eaten the fish elsewhere," said Bob Wakeman, aquatic invasive species coordinator for DNR. "Bilge water from boats also can carry traces of the fish. While these genetic fingerprints are clear enough to help us identify specific invasive carp species, the eDNA testing program relies on multiple positive samples over time to indicate the likelihood of live fish." For example, more than 100 additional samples following a single positive detection for silver carp DNA in Sturgeon Bay in late 2013 did not turn up further evidence of the fish. In the latest case, the single positive sample from the Lower Fox River was among 200 samples collected from the river in June and July. The monitoring was part of a coordinated program that included drawing some 1,950 samples from tributaries to Lake Michigan during the summer months.

In addition to the federal eDNA monitoring, DNR fisheries team members conduct a variety of netting, electroshocking and trawling operations in state waters as part of the ongoing monitoring effort. To date, these efforts have not captured any Asian carp in any waters of the Lower Fox River, Green Bay or Lake Michigan. "The U.S. Fish and Wildlife Service appreciates Wisconsin's commitment to our shared fight against these invaders," said U.S. Fish and Wildlife Service Deputy Regional Director Charlie Wooley. "At the state's request, we are providing all the resources and technical expertise we have available as part of a multistate effort to prevent the establishment of self-sustaining populations of Asian carp in the Great Lakes."

Asian carp species including bighead and silver carp were introduced into the southern United States in the 1970s and eDNA has been found upstream of the electric dispersal barriers in Lake Calumet, seven miles from Lake Michigan on the Indiana-Illinois border as well as in Lake Erie. DNR encourages anglers and others to review Asian carp identification materials, to report any sightings of Asian carp and to make sure that bait buckets don't inadvertently contain the fish because young Asian carp resemble popular bait species. Photo identification tools and more information on Asian carp can be found on DNR's website, dnr.wi.gov, by searching "Asian carp."

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Asian Carp DNA Found in the Fox River

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Asian Carp DNA found in Fox River

Posted: at 1:44 am

Green Bay (WFRV) The Wisconsin Department of Natural Resouces (DNR) reports Asian Carp DNA has been found in the Fox River in Green Bay. Even though the DNA was found in the river, that does not mean the invasive species is in the river.

Here is the news release from the WI DNR:

State pursues additional testing after silver carp environmental DNA detected in Lower Fox River

Weekly News Article Published: October 21, 2014 by the Central Office MADISON -- Continued surveillance to protect Wisconsin waters against invasive species has turned up a single positive environmental DNA, or eDNA, sample for silver carp in the Lower Fox River.

The sample, among hundreds taken statewide in recent months, does not necessarily signal the presence of live fish. To determine the source of the eDNA found in the river, the Wisconsin Department of Natural Resources is collaborating with the U.S. Fish and Wildlife Service and has asked the federal agency for its help to collect additional samples from the Fox River in the next two weeks.

Asian carp pose significant ecological and economic threats to the Great Lakes region and its fishery because they eat voraciously and compete directly with valuable native fish for food.

"The tests for environmental DNA are extremely sensitive and can detect genetic material shed in mucus or excrement from fish as well as from birds that have eaten the fish elsewhere," said Bob Wakeman, aquatic invasive species coordinator for DNR. "Bilge water from boats also can carry traces of the fish. While these genetic fingerprints are clear enough to help us identify specific invasive carp species, the eDNA testing program relies on multiple positive samples over time to indicate the likelihood of live fish." For example, more than 100 additional samples following a single positive detection for silver carp DNA in Sturgeon Bay in late 2013 did not turn up further evidence of the fish. In the latest case, the single positive sample from the Lower Fox River was among 200 samples collected from the river in June and July. The monitoring was part of a coordinated program that included drawing some 1,950 samples from tributaries to Lake Michigan during the summer months.

In addition to the federal eDNA monitoring, DNR fisheries team members conduct a variety of netting, electroshocking and trawling operations in state waters as part of the ongoing monitoring effort. To date, these efforts have not captured any Asian carp in any waters of the Lower Fox River, Green Bay or Lake Michigan. "The U.S. Fish and Wildlife Service appreciates Wisconsin's commitment to our shared fight against these invaders," said U.S. Fish and Wildlife Service Deputy Regional Director Charlie Wooley. "At the state's request, we are providing all the resources and technical expertise we have available as part of a multistate effort to prevent the establishment of self-sustaining populations of Asian carp in the Great Lakes."

Asian carp species including bighead and silver carp were introduced into the southern United States in the 1970s and eDNA has been found upstream of the electric dispersal barriers in Lake Calumet, seven miles from Lake Michigan on the Indiana-Illinois border as well as in Lake Erie. DNR encourages anglers and others to review Asian carp identification materials, to report any sightings of Asian carp and to make sure that bait buckets don't inadvertently contain the fish because young Asian carp resemble popular bait species. Photo identification tools and more information on Asian carp can be found on DNR's website, dnr.wi.gov, by searching "Asian carp."

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Asian Carp DNA found in Fox River

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Genome Engineering with CompoZr Custom Zinc Finger Nucleases (ZFNs) – Video

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Genome Engineering with CompoZr Custom Zinc Finger Nucleases (ZFNs)

By: Sigma-Aldrich

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NC State researchers advance genome editing technique

Posted: at 1:43 am

PUBLIC RELEASE DATE:

21-Oct-2014

Contact: Mick Kulikowski mick_kulikowski@ncsu.edu 919-515-8387 North Carolina State University @NCStateNews

Customized genome editing the ability to edit desired DNA sequences to add, delete, activate or suppress specific genes has major potential for application in medicine, biotechnology, food and agriculture.

Now, in a paper published in Molecular Cell, North Carolina State University researchers and colleagues examine six key molecular elements that help drive this genome editing system, which is known as CRISPR-Cas.

NC State's Dr. Rodolphe Barrangou, an associate professor of food, bioprocessing and nutrition sciences, and Dr. Chase Beisel, an assistant professor of chemical and biomolecular engineering, use CRISPR-Cas to take aim at certain DNA sequences in bacteria and in human cells. CRISPR stands for "clustered regularly interspaced short palindromic repeats," and Cas is a family of genes and corresponding proteins associated with the CRISPR system that specifically target and cut DNA in a sequence-dependent manner.

Essentially, the authors say, bacteria use the system as a defense mechanism and immune system against unwanted invaders such as viruses. Now that same system is being harnessed by researchers to quickly and more precisely target certain genes for editing.

"This paper sheds light on how CRISPR-Cas works," Barrangou said. "If we liken this system to a puzzle, this paper shows what some of the system's pieces are and how they interlock with one another. More importantly, we find which pieces are important structurally or functionally and which ones are not."

The CRISPR-Cas system is spreading like wildfire among researchers across the globe who are searching for new ways to manipulate genes. Barrangou says that the paper's findings will allow researchers to increase the specificity and efficiency in targeting DNA, setting the stage for more precise genetic modifications.

The work by Barrangou and Beisel holds promise in manipulating relevant bacteria for use in food think of safer and more effective probiotics for your yogurt, for example and in model organisms used in agriculture, including gene editing in crops to make them less susceptible to disease.

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NC State researchers advance genome editing technique

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Eczema Treatment in London – Video

Posted: at 1:43 am


Eczema Treatment in London
For world class eczema treatment on London #39;s Harley Street come to http://claudialouch.com for a natural remedy to eczema.

By: The Claudia Louch Natural Skin Clinic

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Eczema Treatment in London - Video

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DermaMed Psoriasis Kit – Rescue Balm and Nutrition for Troubled Skin – Video

Posted: at 1:43 am


DermaMed Psoriasis Kit - Rescue Balm and Nutrition for Troubled Skin
http://www.biologicalhealthgroup.com/product/dermamed-psoriasis-kit/ Provides a focused, two-step support program for managing psoriasis. Contains a powerful...

By: PDC BiologicalHealthGroup

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Novartis' plaque psoriasis drug candidate AIN457 gets FDA committee recommendation

Posted: at 1:43 am

PBR Staff Writer Published 21 October 2014

The US Food and Drug Administration's (FDA) Dermatologic and Ophthalmic Drugs Advisory Committee (DODAC) has approved Novartis' AIN457 (secukinumab), a selective interleukin-17A (IL-17A) inhibitor, to treat moderate-to-severe plaque psoriasis in adult patients.

The DODAC recommendation is based on the safety and efficacy outcomes from ten psoriasis Phase II/III clinical trials which included nearly 4,000 patients with moderate-to-severe plaque psoriasis.

Novartis Pharmaceuticals global head development Vas Narasimhan said moderate-to-severe psoriasis is a serious condition where patients suffer from skin lesions that cause itching, pain and scaling.

"There is a need for novel therapies as not all treatments are appropriate or effective in every patient," Narasimhan said.

"Today's recommendation is based on the efficacy and safety data put forth in our robust clinical trial program and brings us one step closer to delivering an innovative, new treatment option for people suffering from moderate-to-severe psoriasis. We look forward to working with the FDA as it finalizes its review."

The Phase III clinical program for secukinumab included four placebo-controlled pivotal trials which examined secukinumab 300mg and 150mg in patients with moderate-to-severe plaque psoriasis.

In these studies, secukinumab met all primary and key secondary endpoints, including Psoriasis Area and Severity Index (PASI) 75 and 90 and Investigator's Global Assessment modified 2011 (IGA mod 2011) 0/1 responses, showing significant skin clearance at Week 12.

The company submitted a Biologics License Application (BLA) for secukinumab to the FDA in October 2013 and the FDA action date is expected in early 2015.

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Novartis' plaque psoriasis drug candidate AIN457 gets FDA committee recommendation

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OHSU, partners Kineta, UW, VGTI Florida awarded NIH contract to develop vaccine adjuvants

Posted: at 1:42 am

PUBLIC RELEASE DATE:

20-Oct-2014

Contact: Todd Murphy murphyt@ohsu.edu 503-494-8231 Oregon Health & Science University @ohsunews

Oregon Health & Science University's Vaccine & Gene Therapy Institute (OHSU), has been awarded a $10 million contract from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). Kineta, Inc., the University of Washington Center for Innate Immunity and Immune Disease (CIIID), and the Vaccine & Gene Therapy Institute of Florida (VGTI Florida) will collaborate with OHSU as major sub-contractors to develop new vaccine adjuvants that could boost the effectiveness of a wide range of human vaccines for infectious diseases including West Nile Virus, Dengue and Japanese Encephalitis. The work will also provide novel applications for enhancing the immune response against Ebola virus, HIV, and other virus infections. Infectious diseases affect millions of people in developed and developing nations, many with no effective protective vaccines.

Vaccines are the first line of defense against infectious disease and have saved millions of lives over the years. However, some people with weakened immune systems and the elderly lose the ability to respond to vaccines. The effectiveness of vaccines can be improved by the addition of substances called adjuvants that not only enhance the body's immune response to the vaccine but also decrease the dose of the vaccine, allowing the vaccine supply to be extended.

Currently, the Food and Drug Administration has approved only three vaccine adjuvants. This award is part of an NIH push to develop more adjuvants.

"Although vaccines are extremely effective at preventing disease, the elderly and infants, who are the most vulnerable part of our population, are not efficiently protected," said Jay Nelson, Ph.D., professor and director of OHSU's VGTI, who will co-lead work on the NIH contract. "For example, while 80 percent of normal healthy adults are protected with the flu vaccine, more than 40 percent of people over 65 do not develop protective immunity. We have found that the addition of adjuvants to vaccines can better protect older animals from virus infection," Nelson added.

Nelson and other OHSU VGTI scientists will work with Shawn Iadonato, Ph.D., Chief Scientific Officer for Kineta, Inc., a biotechnology company in Seattle, on the development of new adjuvants using the company's innate immune drug development platform.

"Kineta has significant experience in high through-put methods to identify chemical compounds that stimulate the immune system and that are safe and effective. Developing these new adjuvants could change the paradigm for generating lasting immunity to pathogens," said Dr. Iadonato.

Michael Gale, Jr., Ph.D., Professor of Immunology and Director of the CIIID at the University of Washington, will co-lead this project with Nelson. "The identification of new adjuvants will also be important to make vaccines for other diseases such as Ebola virus, influenza A virus, HIV, bacterial infection, and cancer more effective," Gale said.

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Politically Incorrect KLAV- 10/16/2014 (made with Spreaker) – Video

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Politically Incorrect KLAV- 10/16/2014 (made with Spreaker)
Source: http://www.spreaker.com/user/radiomarkowitz/politically-incorrect-klav-10-16-2014 On today #39;s episode, live from the KLAV Studio in Las Vegas NV, we d...

By: Warren Markowitz

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