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Category Archives: Transhuman News

Zelig Eshhar and Carl H. June honored for research on T cell engineering for cancer immunotherapy

Posted: November 11, 2014 at 5:42 pm

PUBLIC RELEASE DATE:

11-Nov-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, November 11, 2014--Zelig Eshhar, PhD, The Weizmann Institute of Science and Sourasky Medical Center, and Carl H. June, MD, PhD, Perelman School of Medicine, University of Pennsylvania, are co-recipients of the Pioneer Award, recognized for lentiviral gene therapy clinical trials and for their leadership and contributions in engineering T-cells capable of targeting tumors with antibody-like specificity through the development of chimeric antigen receptors (CARs). Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, is commemorating its 25th anniversary by bestowing this honor on the leading Pioneers in the field of cell and gene therapy selected by a blue ribbon panel* and publishing a Pioneer Perspective by the award recipients. The Perspectives by Dr. Eshhar and Dr. June are available free on the Human Gene Therapy website at http://www.liebertpub.com/hgt until December 11, 2014.

In his Pioneer Perspective entitled "From the Mouse Cage to Human Therapy: A Personal Perspective of the Emergence of T-bodies/Chimeric Antigen Receptor T Cells" Professor Eshhar chronicles his team's groundbreaking contributions to the development of the CAR T-cell immunotherapeutic approach to treating cancer. He describes the method's conceptual development including initial proof-of-concept, and the years of experimentation in mouse models of cancer. They first tested the CAR T-cells on tumors transplanted into mice then progressed to spontaneously developing cancers in immune-competent mice, which Dr. Eshhar describes as "a more suitable model that faithfully mimics cancer patients." He recounts successful antitumor effects in mice with CAR modified T-cells injected directly into tumors, with effects seen at the injection site and at sites of metastasis, and even the potential of the CAR T-cells to prevent tumor development.

Dr. Carl H. June has led one of the clinical groups that has taken the CAR therapeutic strategy from the laboratory to the patients' bedside, pioneering the use of CD19-specific CAR T-cells to treat patients with leukemia. In his Pioneer Perspective, "Toward Synthetic Biology with Engineered T Cells: A Long Journey Just Begun" Dr. June looks back on his long, multi-faceted career and describes how he combined his knowledge and research on immunology, cancer, and HIV to develop successful T-cell based immunotherapies. Among the lessons Dr. June has embraced throughout his career are to follow one's passions. He also says that "accidents can be good: embrace the unexpected results and follow up on these as they are often times more scientifically interesting than predictable responses from less imaginative experiments."

"These two extraordinary scientists made seminal contributions at key steps of the journey from bench to bedside for CAR T-cells," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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*The blue ribbon panel of leaders in cell and gene therapy, led by Chair Mary Collins, PhD, MRC Centre for Medical Molecular Virology, University College London selected the Pioneer Award recipients. The Award Selection Committee selected scientists that had devoted much of their careers to cell and gene therapy research and had made a seminal contribution to the field--defined as a basic science or clinical advance that greatly influenced progress in translational research.

About the Journal

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Zelig Eshhar and Carl H. June honored for research on T cell engineering for cancer immunotherapy

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OBAMA PUSHES TPP IN CHINA TO GET NET NEUTRALITY. INTERNET CENSORSHIP. – Video

Posted: at 5:41 pm


OBAMA PUSHES TPP IN CHINA TO GET NET NEUTRALITY. INTERNET CENSORSHIP.
http://www.dailymail.co.uk/news/article-2828549/Obama-asks-FCC-strong-net-neutrality-rules.html ...

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Putin's gesture to leader's wife covered up by Chinese

Posted: at 5:41 pm

Russia's President Vladimir Putin (R) helps put a blanket on Peng Liyuan, wife of China's President Xi Jinping, as they watch watch a lights and fireworks show to celebrate Asia-Pacific Economic Cooperation (APEC) Leaders' Meeting, at National Aquatics Center, or Water Cube, in Beijing, November 10, 2014. CHINA STRINGER NETWORK, REUTERS

BEIJING -- It was a warm gesture on a chilly night when Vladimir Putin wrapped a shawl around the wife of Xi Jinping while the Chinese president chatted with Barack Obama. The only problem: Putin came off looking gallant, the Chinese summit host gauche and inattentive.

29 Photos

Russian leader often seeks to foster image as rugged nature lover, but his stunts have seen opponents ridicule him as a strongman selling an imag...

Worse still were off-color jokes that began to circulate about the real intentions of the divorced Russian president - a heartthrob among many Chinese women for his macho, man-of-action image.

That was too much for the Chinese authorities.

The incident at a performance linked to this week's Asia-Pacific summit originally was broadcast on state broadcaster CCTV and spread online as a forwarded video. But it was soon scrubbed clean from the Chinese Internet, reflecting the intense control authorities exert over any material about top leaders while also pointing to cultural differences over what's considered acceptable behavior in public.

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While in Beijing for a global economic summit, President Obama briefly spoke with Russian President Vladimir Putin about Ukraine. Obama also stru...

"China is traditionally conservative on public interaction between unrelated men and women, and the public show of consideration by Putin may provide fodder for jokes, which the big boss probably does not like," said Beijing-based historian and independent commentator Zhang Lifan.

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Putin's gesture to leader's wife covered up by Chinese

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Gold, Peace, and Prosperity by Ron Paul – Full Audiobook – Video

Posted: at 5:41 pm


Gold, Peace, and Prosperity by Ron Paul - Full Audiobook
Ron Paul has been the leading champion of sound money in the Congress. Here he explains why sound money means a new gold standard. The monograph is written i...

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After serving country, Lanham Marine served fellow vets — Gazette.Net

Posted: at 5:40 pm

Jamie Anfenson-Comeau/The Gazette

U.S. Marine Corps veteran Sam Hofberg of Lanham, at the Greenbelt American Legion Post 136 where he has served for over 60 years.

When the Greenbelt American Legion Post 136 remodeled their banquet hall last year, they decided to name it in honor of one of their longest-serving members and chaplain emeritus, Sam Hofberg of Lanham.

Post 136 Commander Michael Moore said Hofberg is modest about his own efforts on behalf of veterans, but the Post wanted to do something to honor Hofberg for his work with the Post, particularly as chaplain.

Hes one of the finest human beings Ive ever known, Moore said. Hes always been the first to volunteer, the first to reach out to help fellow veterans.

At 92, Hofberg is one of the longest-serving members of the American Legion Post 136 Greenbelt, having joined the post after returning from World War II.

During his time at the post, he has served twice as post commander, in 1983 and 1991, and held just about every other office available, according to Moore.

Hofberg doesnt like to talk about his own accomplishments, but he is proud of the time, over 25 years, that he served as chaplain for the Post.

I felt very dedicated to being chaplain. When you take that job, you have to take care of all veterans, of all nationalities and religions, Hofberg said. I performed services for everyone, no matter who they were.

Hofberg said not everyone was able to do that.

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After serving country, Lanham Marine served fellow vets -- Gazette.Net

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Microsofts human-resources chief Lisa Brummel leaving

Posted: at 5:40 pm

Originally published November 10, 2014 at 7:06 PM | Page modified November 10, 2014 at 8:50 PM

Lisa Brummel, leader of Microsoft human resources for nearly a decade, will step down at the end of the year.

Brummel, executive vice president for human resources, is a 25-year veteran of the company and part-owner of the Seattle Storm. She has held a variety of roles in management and marketing in Microsofts hardware, consumer and productivity businesses, and has led human resources since 2005.

She will be succeeded in the HR post by Kathleen Hogan, who currently leads Microsoft Services.

Microsoft Services, with about 21,000 employees, is Microsofts customer-support and consulting network and the largest single organization within the company.

Hogan joined Microsoft in 2003, and previously worked for the McKinsey consulting firm, as well as Oracle.

Kathleen is an accomplished, well-respected and well-rounded leader who obsesses over our customers and is motivated by peoples passion for how technology can change the world, Chief Executive Satya Nadella said. She is the right person to continue pushing our cultural transformation forward, and she will ensure Microsoft remains the best, most inclusive place to work.

Brummel grew up in Westport, Conn., and joined Microsoft in 1989 after receiving a masters in business administration from UCLA. An athlete during undergraduate years at Yale University, Brummel was part of a group of four Storm season-ticket holders who joined forces to buy the team from Clay Bennett in 2008.

Most of Brummels years at the helm of human resources came during Microsofts oft-criticized practice of stack-ranking, the process of ranking employees during performance reviews. Some employees said the system lowered morale and limited the incentives for workers to collaborate.

Under stack ranking, managers were required to designate their staff into five groups from top to bottom performers based on set percentages. Even if everyone in a team performed well, managers were required to designate some as underperformers.

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After serving country, Lanham Marine served fellow vets

Posted: at 5:40 pm

Jamie Anfenson-Comeau/The Gazette

U.S. Marine Corps veteran Sam Hofberg of Lanham, at the Greenbelt American Legion Post 136 where he has served for over 60 years.

When the Greenbelt American Legion Post 136 remodeled their banquet hall last year, they decided to name it in honor of one of their longest-serving members and chaplain emeritus, Sam Hofberg of Lanham.

Post 136 Commander Michael Moore said Hofberg is modest about his own efforts on behalf of veterans, but the Post wanted to do something to honor Hofberg for his work with the Post, particularly as chaplain.

Hes one of the finest human beings Ive ever known, Moore said. Hes always been the first to volunteer, the first to reach out to help fellow veterans.

At 92, Hofberg is one of the longest-serving members of the American Legion Post 136 Greenbelt, having joined the post after returning from World War II.

During his time at the post, he has served twice as post commander, in 1983 and 1991, and held just about every other office available, according to Moore.

Hofberg doesnt like to talk about his own accomplishments, but he is proud of the time, over 25 years, that he served as chaplain for the Post.

I felt very dedicated to being chaplain. When you take that job, you have to take care of all veterans, of all nationalities and religions, Hofberg said. I performed services for everyone, no matter who they were.

Hofberg said not everyone was able to do that.

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After serving country, Lanham Marine served fellow vets

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Shine On (Protoxic & Futurism Remix) – Video

Posted: at 5:40 pm


Shine On (Protoxic Futurism Remix)
Shine On B.Vivant Corey Andrew 2013 Roba Music Publishing Released on: 2013-07-29 Auto-generated by YouTube.

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Ending up in flames while denying futurism – Video

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Ending up in flames while denying futurism
Ending up in flames while denying futurism I Fused Ici d #39;Ailleurs Released on: 2005-12-20 Composer: Lavaysse David Music Publisher: Ici d #39;Ailleurs Auto...

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Ending up in flames while denying futurism - Video

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Futurist Limited – Video

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Futurist Limited
Futurist Limited Spahn Ranch 1997 Cleopatra Records Released on: 2006-04-25 Auto-generated by YouTube.

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Futurist Limited - Video

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