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Category Archives: Transhuman News

First gene therapy drug sets million-euro price record

Posted: November 26, 2014 at 1:45 pm

FRANKFURT/LONDON - The Western world's first gene therapy drug is set to go on sale in Germany with a 1.1 million euro ($1.4 million) price tag, a new record for a medicine to treat a rare disease.

The sky-high cost of Glybera, from Dutch biotech firm UniQure and its unlisted Italian marketing partner Chiesi, shows how single curative therapies to fix faulty genes may upend the conventional pharmaceutical business model.

After a quarter century of experiments and several setbacks, gene therapy is finally throwing a life-line to patients by inserting corrective genes into malfunctioning cells - but paying for it poses a challenge.

The new drug fights an ultra-rare genetic disease called lipoprotein lipase deficiency (LPLD) that clogs the blood with fat. The medicine was approved in Europe two years ago but its launch was delayed to allow for the collection of six-year follow-up data on its benefits.

Now Chiesi has filed a pricing dossier with Germany's Federal Joint Committee, or G-BA, which will issue an assessment of the drug's benefits by the end of April 2015. The company is seeking a retail price of 53,000 euros per vial, or 43,870 euros ex-factory.

That equates to 1.11 million euros for an typical LPLD patient, averaging 62.5 kg in clinical trials, who will need 42 injections from 21 vials. This price will be subject to a standard 7 percent discount under Germany's drug pricing system.

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"Horrible Bosses 2": How horrible is it?

Posted: at 1:45 pm

"Horrible Bosses 2": How horrible is it?

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Find out what to see in the upcoming movie season

The "horrible bosses" are back with a sequel, but it does the film live up to the 2011 original?

The new movie, out Wednesday, stars Jason Bateman, Jason Sudeikis, Charlie Day, Jennifer Aniston, Chris Pine, Christoph Waltz, Jamie Foxx and Kevin Spacey. In the sequel, Dale, Kurt and Chris decide to start their own company but it doesn't go as planned because of a slick investor and a kidnapping scheme.

At last check "Horrible Bosses 2" had just a 30 percent rating on movie review aggregator site, Rotten Tomatoes, with some critics saying the jokes simply fall flat. Others are calling the movie "inappropriate," "racist" and "politically incorrect."

Take a closer look at what critics say:

Bilge Ebiri of New York magazine writes, "It's not really about bosses or office politics. Its only allegiance seems to be to the law of the sequel: It puts the same characters into a vaguely familiar situation, with diminishing, tepid returns. They should have just called it 2."

Claudia Puig of USA Today says: "Bateman's comic timing and slow burn have slackened into blandly dull reactions, while his partners in crime seem to have grown markedly less intelligent...This sequel is misogynistic and occasionally racist. Edgy, inappropriate humor has its appeal, but 'Horrible Bosses 2' is merely offensive, without the barest minimum of wit."

The New York Times' Stephen Holden calls it "one of the sloppiest and most unnecessary Hollywood sequels ever made," adding, "But it is infinitely dumber and not half as funny. ... The story doesn't even try to make sense. You often have the queasy feeling that the screenplay was improvised on the spot."

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"Horrible Bosses 2": How horrible is it?

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Fear, Panic & Censorship – Video Nasty Documentary – Video

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Fear, Panic Censorship - Video Nasty Documentary
Rare documentary about Video Nasties and film, video and internet censorship in the UK. Was first screened as part of Channel 4 #39;s controversial "Banned Weeke...

By: ThisAintMyShoe

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Opie & Anthony Facebook Censorship, Language and Culture Policing 02 20 14 – Video

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Opie Anthony Facebook Censorship, Language and Culture Policing 02 20 14

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Opie & Anthony Facebook Censorship, Language and Culture Policing 02 20 14 - Video

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Europe wants Google to expand 'right to be forgotten' censorship to global search

Posted: at 1:45 pm

Google should start applying the European Unions right to be forgotten to its global, .com domain, European privacy regulators say.

European data protection authorities in the so-called Article 29 Working Party (WP29) have compiled a set of guidelines detailing how search engines should apply a court ruling that gave Europeans the right to be forgotten by search engines. As of the May decision, EU citizens have the right to compel search engines to remove search resultsin Europe for queries that include their names if the results are inadequate, irrelevant or no longer relevant, or excessive.

However, it is not enough to only de-list search results on EU domains, the WP29 said in a news release Wednesday. In order to give full effect to a persons rights as defined in the courts ruling, link removals in search results should be extended to .com domains.

Limiting de-listing to EU domains on the grounds that users tend to access search engines via their national domains cannot be considered a sufficient means to satisfactorily guarantee the rights of a person according to the ruling, the group said. In practice, this means that in any case, de-listing should also be effective on all relevant .com domains in order to prevent circumvention of EU laws.

The guidelines, which have not yet been published in full, will probably cause a further escalation of the battle between privacy regulators and Google, as the search engine has so far refused to remove links on its .com domain.

Further reading:Wikipedia's Jimmy Wales: 'Right to be forgotten' is censorship

Google has been removing links from all 28 EU country domains, as well as from the Google domains in Iceland, Liechtenstein, Norway and Switzerland, countries belonging to the European Free Trade Association (EFTA).

Links, however, are not removed from the international, .com domain, as it is clear to the company that other courts in other parts of the world wouldnt have reached the same conclusion as the Court of Justice of the European Union (CJEU), Googles Global Privacy Council, Peter Fleischer, explained last week.

Whether Google will change its policy remains unclear. We havent yet seen the Article 29 Working Partys guidelines, but we will study them carefully when theyre published, a Google spokesman said.

The WP29s guidelines also contain a list of common criteria that data protection authorities will apply to handle complaints filed with national offices following refusals of de-listing by search engines. The list contains 13 main criteria that should be applied on a case-by-case basis, and aims to provide a flexible tool to help authorities to make the right decisions.

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Europe wants Google to expand 'right to be forgotten' censorship to global search

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Libertarian Party lashes out at the newly warlike Rand Paul

Posted: at 1:44 pm

FILE - In this June 20, 2014 file photo Sen. Rand Paul, R-Ky. speaks in Washington. Their party has seized the Senate majority. Now, an ambitious class of Republican senators faces unique challenges, and opportunities, in a GOP-led Senate under ... more >

Some are not happy with Sen. Rand Pauls recent resolution for a declaration of war against the Islamic State. We agree with your father, Ron Paul, who for decades was a lonely yet brave voice in Congress for peace. He was right when he called for getting the U.S. military out of the Middle East. Everyone knows that youre posturing to get the Republican nomination for president in 2016, says Libertarian Party chairman Nicholas Sarwark in an open letter to the Kentucky Republican.

But for this long-shot hope of winning the nomination, you have endorsed a roster of hawkish big government Republicans - from Mitt Romney to Mitch McConnell. And now youre calling for sending our troops back to Iraq, which will be a death sentence for many of them, Mr. Sarwark cautions.

Just how much can your long-shot presidential bid be worth? Is it worth the lives of these young men and women? The Libertarian Party says Absolutely not! While we agree with your view that no funds should be allocated to an illegal war, a policy of non-intervention remains the only just and reasonable approach to dealing with the Middle East - a land halfway around the world where the United States does not belong, Mr. Sarwark says. Your bid for a declaration of war against ISIS is unjustifiable and dangerous. Please withdraw it immediately.

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Libertarian Party lashes out at the newly warlike Rand Paul

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Ferguson Burns. R these Actors ? – Video

Posted: at 1:44 pm


Ferguson Burns. R these Actors ?
This chick loos like an actor or something. Im so not buying it. Look at this nonsense.. Tags dollar, crash, obama, border, isis, isil, collapse, ebola, hyperinflation, conspiracy, big brother,...

By: MAXLIBERTY

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Ferguson Burns. R these Actors ? - Video

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News, Libertarianism and Obama (part 8 of 10, made with Spreaker) – Video

Posted: at 1:44 pm


News, Libertarianism and Obama (part 8 of 10, made with Spreaker)
Source: http://www.spreaker.com/user/letstalkfreedom/news-libertarianism-and-obama.

By: Robert Cancel

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News, Libertarianism and Obama (part 7 of 10, made with Spreaker) – Video

Posted: at 1:44 pm


News, Libertarianism and Obama (part 7 of 10, made with Spreaker)
Source: http://www.spreaker.com/user/letstalkfreedom/news-libertarianism-and-obama.

By: Robert Cancel

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News, Libertarianism and Obama (part 7 of 10, made with Spreaker) - Video

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News, Libertarianism and Obama (part 1 of 10, made with Spreaker) – Video

Posted: at 1:44 pm


News, Libertarianism and Obama (part 1 of 10, made with Spreaker)
Source: http://www.spreaker.com/user/letstalkfreedom/news-libertarianism-and-obama.

By: Robert Cancel

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News, Libertarianism and Obama (part 1 of 10, made with Spreaker) - Video

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