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Category Archives: Transhuman News

The slow ageing of tortoises could unlock secrets to human longevity, says study – HeraldScotland

Posted: June 29, 2022 at 12:40 am

A new study looking at creatures such as tortoises and turtles has found that theyhave biological mechanisms that slow down or even completely switch offageing, which may indicate a way to extend human longevity.

As reported by The Independent,the research, published in thejournalScienceon Thursday, looked at signs of senescence the gradual process of deterioration of physical and functional characteristics among tortoises and turtles living in zoos and aquariums.

The international team of scientistsfound that the pattern of ageing in these cold-blooded creatures does not resemble that seen in humans or other animals.

Most of the studied creatures aged slower, and in some cases, their senescence is negligible, scientists said.

Creatures that were studied included77 cold-blooded species from 107 wild populations, including turtles, amphibians, snakes, crocodilians and tortoises.

Species of tortoise were found to have less senescence (Canva)

Of the 52 species analysed in the study, scientists said three-fourths of them showed extremely slow senescence, while 80%appeared to have slower ageing than modern humans.

Some of the species have the ability to reduce their rate of ageing in response to the improved living conditions in zoos and aquariums, compared to the wild, scientists say.

Theories around senescence suggest that it begins after sexual maturity, where it invests more energy in reproduction than in repairing cells and tissue.

Due to this tradeoff, researchers have held that after reaching sexual maturity, individuals inevitably stop growing and start experiencing senescence a prediction that has been confirmed for several species, particularly mammals and birds.

Turtles and tortoises, and other organisms that keep growing after sexual maturity, could have the ability to keep investing in repairing cellular damages - which then avoid the effects of senescence.

Although humans have witnessed unprecedented increases in longevity in the last century, scientists say improved living conditions does not modify the rate of ageing in humans and other primates.

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Longevity Investors Conference to be held in Gstaad, Switzerland Sept. 2830 – Cointelegraph

Posted: at 12:40 am

Longevity Investors Conference (LIC) returns for its third annual edition from Sept. 2830 in Gstaad, Switzerland.

The conference attracts the worlds top longevity leaders, institutional and private investors, wealthy private investors and family offices and funds in an exclusive setting. For two days, opinion leaders and high-ranking representatives will exchange their knowledge about longevity, trends, attractive investments and business opportunities in the longevity space. The conference will ensure a private atmosphere and the opportunity to establish partnerships with other business leaders and investment opportunities in a unique setting at Le Grand Bellevue, a five-star hotel in Gstaad and one of the most exclusive Swiss mountain resorts.

The LIC has the honor of welcoming leading longevity experts and scientists, such as Harvard Medical School genetics professor George Church, SENS Research Foundation chief of science offices Aubrey de Grey, Buck Institute for Research on Ageing president and CEO Eric Verdin, Institute for Ageing Research at Albert Einstein College of Medicine director Nir Barzilai, Forever Healthy Foundation founder Michael Greve, Human Longevity Inc. associate professor, internal medicine specialist and longevity physician Evelyne Yehudit Bischof, Insilico Medicine founder and CEO Alex Zhavoronkov, First Longevity founder and Longevity.Technology editor-in-chief Phil Newman, and Wei-Wu He, Human Longevity Inc. executive chairman, Casi Pharmaceuticals Inc. CEO and chairman, and Genetron Health founder and chairman.

More speakers will be announced closer to the conference.

LIC was initiated by Tobias Reichmuth and Marc Bernegger, two successful serial entrepreneurs who, among others, launched CfC St. Moritz, one of the most exclusive conferences for digital assets.

Keynote speeches, fireside chats, panel discussions and breakout sessions on topics including biotech, aging technology, diagnostics, AI, health prevention, longevity therapy and investment strategy await the attendees of the 2022 conference.

The conference is in the Bellevue Hotel in Gstaad, recently rated Hotel of the Year by the Swiss media. The hotel will be privatized for LICs guests, ensuring an exclusive networking experience. Some of the conferences partners include PricewaterhouseCoopers, Credit Suisse, Maximn, Korify Capital, Apollo Health Ventures, Clinique La Prairie, Biolytica AG, Avea Solutions and many more.

The unique event format combines rich content and insight-sharing during the day, with numerous opportunities to recharge and network at the lunches, evening receptions, dinners and longevity experiences occurring during the course of the two-day conference.

There are more and more traditional investors joining the longevity space, which creates massive investment opportunities. The special setup of this years conference enables not only knowledge exchange but also effective community-building, which is very unique for the industry and has never happened before to this extent, said Marc Bernegger, one of the driving forces behind the conference.

Tobias Reichmuth, co-founder of LIC and Berneggers partner, said, The longevity industry will be one of the biggest investment opportunities during the next decade expected to be worth at least $600 billion by 2025. It is experiencing great momentum, and this is the ideal time to use it in favor of educating and spreading information to investors. In a sea of science-oriented conferences, a professional and global investor-focused longevity conference such as LIC will provide an opportunity for the industrys top investors and innovators to get acquainted with recent developments and breakthroughs.

Early bird tickets are available until the end of June on the site.

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The Rejuvenation Startup Summit Speakers – Lifespan.io News

Posted: at 12:40 am

Berlin/Germany, June 23, 2022 TheRejuvenation Startup Summit(Berlin, Oct. 14-15, 2022) is a vibrant networking event that brings together startups and members of the longevity venture capital/investor ecosystem all aiming to create therapies to vastly extend the healthy human lifespan. Rejuvenation/Longevity biotech is a new, emerging field of medicine. It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself.

In addition to an exciting range of presentations from CEOs of startups in the field of rejuvenation/longevity, the summit features an all-day startup forum for vibrant networking. Starting midday on Friday and finishing off on Saturday night with a big party, it offers ample opportunity to get in touch, learn and network with some of the most promising companies in the field like:

Investors may explore concrete investment opportunities, or if new to the field, get jumpstarted on the upcoming new megatrend Rejuvenation/Longevity a still young industry that will eventually become much bigger than todays largest technology markets.

Early Bird pricing for theRejuvenation Startup Summit (Oct 14-15) ticketsstays effective till Thursday, 21 of July, 12:00 pm CET (03:00 am Pacific).

The Rejuvenation Startup Summit (Berlin, Oct. 14-15, 2022) hosted by the Forever Healthy Foundation, is a vibrant networking event that aims to accelerate the development of the rejuvenation biotech industry.

Rejuvenation/Longevity biotech is a new, emerging field of medicine. It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself.Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification, tissue stiffening, loss of stem cell function, genetic alterations, and impaired energy production.

The Summit brings together startups, members of the longevity venture capital / investor ecosystem, and researchers interested in founding or joining a startup all aiming to create therapies to vastly extend the healthy human lifespan.

Further information can be found atwww.forever-healthy.org/summit.

Frank Schueler, Chief Operating Officer

[emailprotected]

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Your immunity has a life span – The New Indian Express

Posted: at 12:40 am

Express News Service

HYDERABAD: Ageing of the immune system is becoming a matter of concern, more so, amid the pandemic. But what does immune ageing even mean? Is that a concern for just the researchers or us too? For answers to these and more, experts explain it all to CE. Dr G Navodaya, consultant, general medicine, Care Hospitals, Banjara Hills, feels that immune ageing has a wider perspective and says, Immune ageing is a phenomenon that occurs in any patient who is ageing, so this is not specific to immunity.

The human body has many cells with unique responsibilities. Some keep the person alive, others build muscle structure, and some maintain the functions of the body, etc. Now, every cell has a basic function and age and after a certain function and time, the cells die. Immunity ageing is the same if a person is ageing, meaning, growing older, they are likely to see physical changes in and outside the body. Similarly, cell functions start to reduce inside the body, eventually. Cells that maintain our immunity to help fight infections too meet the same fate.

So what does this mean for us? He responds, Immunity is maintained so as to protect us from infections. But when these cells have less strength then the human body is prone to infections. He adds that immune ageing happens not just when one turns older but the process is fastened if habits like smoking and drug intake grow.

Dr Jagadeesh Kumar V, consultant physician at KIMS Hospital, Secunderabad, says that when one bears the brunt of too many infections, the immune cells in the body take a hit. The advent of Covid has worsened this fear. Immune ageing, which is otherwise called inflammaging, points that inflammation in our body is growing or ageing. Every time a body undergoes inflammation or infection, peoples immunity ages. The cells lose their functional capacity once a person is infected, says he.

Talking about the aftermath of this, he says, people become obese, theyre vulnerable to infection, their cognition declines (memory comes down), comprehensive capacity and capability come down, etc. On a concluding note he adds that stress too, is a catalyst for immune ageing. Lack of sleep, unhealthy lifestyle lead to stress, which is making many prone to immune ageing and thus, to many diseases, he cautions.

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PGA urges to protect the ocean, ensure its health and longevity – Raajjemv

Posted: at 12:40 am

Abdulla Shahid, President of the 76th session of the United Nations General Assembly (UNGA) has urged communities across the globe to protect the ocean and ensure its health and longevity.

He said this in his remarks at the opening ceremony of the 2022 UN Oceans Conference on Monday, where he spoke extensively on the concrete, demonstrable action required to underscore the commitment to save the ocean, to protect it against the threats - both human-driven and otherwise - that would take it away from us.

The PGA noted that the ocean being an essential part of life on this planet is an inescapable reality for him as a person and as a Maldivian, adding that for small islanders, coastal residents, workers dependent on tourism and coral reefs, fisherpersons and for all those who turn to the ocean for livelihood, for reprieve, and for enjoyment, this reality rings true.

I am a Maldivian. Whether I am here as President of the General Assembly or not, the ocean is in my blood; it runs through my lifes narrative, from childhood to parenthood; from my career in the Foreign Service to my Parliamentary experience, to what I represent today. I am from a large ocean State. I am a child of the ocean.

Abdulla Shahid, PGA.

Highlighting that beyond those who look to the blue horizon each day, the entirety of humanity relies upon the ocean for half of the oxygen that people intake, the PGA said that the ocean connects communities across the globe.

He added that the ocean connects humanity and the planet, adding that there is no context communities across the globe can live without it.

Stressing that the ocean conference came at a critical and timely opportunity, Shahid noted that on one hand the ocean faces countless threats from climate change to plastic pollution and from over-fishing to acidification and that on the other hand there is momentum.

In this regard, on Friday, we will adopt a declaration, that will give direction and set the tone for our future work. I was pleased to reappoint the Permanent Representative of Grenada, Ms. Keisha McGuire, and Permanent Representative of Denmark Mr. Martin Hermann, for this task. And I commend them and their experts Nerissa Williams and Mira Bergem, for delivering! And thank all Member States for their commitment.

Abdulla Shahid, PGA.

PGA Shahid stated that the 40th anniversary of the UN Convention on Law of the Sea has reiterated the shared responsibility for the ocean, adding that recent efforts such as the landmark agreement on ending plastic pollution and the new World Trade Organization deal on fisheries subsidies, gives cause for hope.

Further, Shahid said that there is optimism towards an international legally binding instrument on the conservation and sustainable use of marine biological diversity of areas beyond national jurisdiction.

He noted that solid partnerships across all stakeholders are being established and strengthened, as observed at the Our Ocean Conference in Palau earlier this year.

With this being said, he highlighted how there is a strong foundation to build upon and how the ocean conference can set the tone for what needs to be done.

PGA Shahid urged the global communities to not fall prey to shortsightedness or lack of ambition, to invest in, trust in, and act upon science.

Shahid, who also serves as the Minister of Foreign Affairs of Maldives, also urged the people to protect the ocean, leverage its power, relish its beauty, cherish its diversity and ensure its health and longevity in order to save it.

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Big Tech Dives into Healthcare With Google Parent Alphabet at the Forefront – The Quint

Posted: at 12:40 am

The market for wearable technology has grown a lot in the last ten years, with fitness and health tracking features being the main USP of most such devices in the market.

Googles 2021 acquisition of Fitbit for over $2 billion was their entry into the wearables market. Since then, the Pixel Watch has also entered the ring, with revolutionary new features.

Aside from the basic features like counting steps taken or calories burned, there are also new technologies being introduced like a sensor that can detect irregularities in the wearers pulse.

This sensor has recently received FDA approval, The Economist reports. Googles Pixel phone cameras can detect heart blood oxygen levels using image processing and their smart home devices can monitor sleep patterns by listening to snoring.

Apple is another strong player in this arena, with their whole arsenal of fitness and health tracking features on the Apple Watch and iPhone.

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Big Tech Dives into Healthcare With Google Parent Alphabet at the Forefront - The Quint

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The Answer to a Red Fox Mystery is in Their DNA – NC State News

Posted: at 12:38 am

Scientists know that Europeans brought red foxes to North America, likely for hunting, while other red foxes escaped into the wild from fur farms. But are some red foxes found on the East Coast, and in North Carolina, native?

According to wildlife genetics expert Liz Kierepka, the answer to this mystery is in their DNA.

The Abstract spoke to Kierepka, who has a joint appointment at NCState and at the North Carolina Museum of Natural Sciences, about what we know so far about the origin of red foxes, Vulpes vulpes, in North Carolina, and in North America more broadly.

The Abstract: Are there native red foxes in the Southeast?

Liz Kierepka: Based on genetic studies, we think the vast majority of red foxes in the Southeast are native to North America and mostly belong to a line of foxes known as the eastern lineage. The eastern lineage is one of three relatively well-established, genetically distinct lineages of red foxes in North America. All of these lineages were separated during the Ice Ages, and we can see differences in their DNA today. There is also another group in Alaska that is more closely related to Asian red foxes.

We know there was an introduction of European red foxes in the mid-Atlantic region of the eastern United States. There is a higher proportion of non-native foxes in Virginia and Maryland because of that introduction, which was dated to about the 1700s. There were also foxes bred for their fur, and many foxes either escaped or were released. A lot of those foxes have interbred with our native foxes.

TA: How far back do foxes go in North America?

Kierepka: Red foxes originated in the Middle East, and then they expanded across the globe. They crossed from Eurasia over the land bridge between Russia and Alaska about 400,000 years ago. When the Ice Ages occurred, previous habitats were covered in ice and foxes had to re-arrange themselves in unglaciated areas. Because of the glaciers, certain populations of foxes were no longer in genetic contact. They then evolved into the genetically different groups that you can still see today.

TA: How do you know all this?

Kierepka: Red foxes have been subject of much genetic study across the years. Researchers from the University of California, Davis were able to identify the three genetically distinct groups of red fox in North America by studying their DNA. The more differences that occur across their DNA sequences, the more differentiated the animals are.

In these genetic analyses, researchers looked at the DNA from the mitochondrion. Mitochondrial DNA is nice for building phylogenetic trees because it often reflects isolation that occurred during the Ice Ages. Mitochondrial DNA is much easier to get than nuclear DNA. There is one nucleus per cell whereas there are hundreds to thousands of mitochondria. You can get the DNA from hair samples, fecal samples or even saliva.

TA: What about red foxes in North Carolina are they native or were they introduced?

Kierepka: The thing is about red foxes in North Carolina is that we havent really looked at the population here closely. In the study that characterized red fox genetics for North America, there were only a handful of samples from North Carolina. Of the few samples that they ran, one was likely a fur farm individual and two were native. It is likely that there are native foxes here, but we dont know the frequency. We just do not have enough samples.

There are historical records where people that would speculate about this question. They suggested the possibility of the introduction of European foxes, but these are from records from the early 1800s and 1900s. There are multiple accounts saying they may have been brought over, but it is hard to verify these records.

TA: Why is it important to try to answer questions like this?

Kierepka: Its important for understanding how species can adapt to new environments. When you have invasive species coming in, it can cause invasive and native species to breed together. This interbreeding can disrupt populations that are adapted to certain environments.

In California, for example, the non-native foxes do really well in human-dominated landscapes, while the native foxes prefer unaltered habitats. Some of these native foxes are on the brink of extinction due to habitat loss and climate change. We might lose some of this genetic diversity that we did not know existed until we looked. I do not know if thats happening in North Carolina or not, but we will only find out if we study it.

In conservation, one of the goals is to preserve as much genetic diversity as we can because it can help species adapt in the future with habitat loss and climate change.

TA: Are gray foxes and red foxes the same species?

Kierepka: Gray foxes are the oldest canid in the dog family. They are so divergent from red foxes; I would be flabbergasted if they hybridized. Its like a rat and a squirrel interbreeding successfully.

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Expert: Suspect’s DNA found on gun that killed Ayshawn Davis, 11 – Times Union

Posted: at 12:38 am

TROY A sample of DNA found on the handgun used in the drive-by shooting of 11-year-old Ayshawn Davis matched the DNA profile of Jahquay Brown, a State Police forensic scientist testified at Browns murder trial Tuesday.

Meredith Pelletier, a DNA expert who has worked with the State Police for 16 years, told jurors Browns profile matched that of the major contributor of DNA on the .40 caliber handgun with the chances of it being from someone else less than 1 in 320 billion.

Police said they discovered the gun in a book bag found in Browns home in Cohoes. The DNA of three lesser contributors was also found on the gun.

Rensselaer County prosecutors allege the evidence backs their contention that Brown, 22, was in a blue Honda Accord that carried the gunman who opened fire at a crowd on Old Sixth Avenue in Troy, killing Davis on Sept. 13, 2020, at 11:20 p.m.

Chief Assistant District Attorney Matthew Hauf has not said Brown was or was not the triggerman. The defendant is not charged with being the shooter, but acting together with another person in the car to commit the murder in a case of depraved indifference second-degree murder.

During cross-examination, Browns defense attorney, Robert Molloy, asked Pelletier about the DNA of the other three people found on the gun.

The DNA that was the most, that had the highest (amount), matched that of Jahquay Brown, Pelletier said.

She testified that a soda bottle recovered from the Honda had DNA that did not match Brown or anyone in the case.

Another prosecution witness, State Police forensic scientist Victoria OConnor, testified that projectile fragments and shell casings found at the crime scene were fired from the weapon found in Browns book bag.

Molloy asked OConnor if she could say who fired the weapon and when. She said she could not.

A forensic pathologist, Bernard Ng, testified later Tuesday that Davis cause of death was severe head trauma from a gunshot to the head.

Hauf, who called 14 witnesses and entered more than 200 pieces of evidence, rested his case.Molloy did not present a defense.

Both sides are expected to deliver closing arguments on Wednesday.

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French Defense Innovation Agency Investigates the Use of DNA Script’s SYNTAX System to Synthesize Custom qPCR Probes for On-demand Detection of…

Posted: at 12:38 am

SOUTH SAN FRANCISCO, Calif. & PARIS--(BUSINESS WIRE)--DNA Script, a world leader in Enzymatic DNA Synthesis (EDS) for DNA on demand, has announced the first successful qPCR assays using primers and probes synthesized by a customer via enzymatic synthesis using the companys SYNTAX System DNA printer. This success was achieved as part of a contract with the French Defense Innovation Agency, in liaison with the French Armament General Directorate (DGA), first announced in January 2021.

The partnership leverages the SYNTAX System to produce high-quality DNA primers and probes to rapidly develop qPCR assays for infectious disease detection. Based on these results, the collaboration has been extended to further test EDS primers and probes for qPCR assay development, giving the DGA access to new versions of synthesis and labeling technologies that the company commercially develops.

This markets applications in biodefense are a strategic focus contributing to the sovereign production of biological assays for the French Ministry for the Armed Forces.

This extension validates the importance of our SYNTAX benchtop DNA printing system for rapid response programs, said Thomas Ybert, CEO and co-founder of DNA Script. We have demonstrated that SYNTAX can consistently print high-quality DNA probes for mobile and onsite deployment, enabling same-day qPCR from design to results, which is an enormous advantage for any pathogen early warning system.

The ultimate goal is to create a platform that can quickly develop new assays targeting biological threats or emerging pathogens during an outbreaks earliest phases.

COVID has taught us that we need to be prepared for new threats, said Ybert. Our work with the DGA takes that preparation to the next level, providing the ability to respond faster to new biothreats.

The SYNTAX System delivers a DNA printing technology that is compliant with the DGAs requirements. The system relies on enzymatic synthesis, a safer, more sustainable technology that does not rely on toxic reagents or produce the hazardous organic waste associated with phosphoramidite chemistry DNA printing.

The SYNTAX printer synthesizes high-quality, custom nucleic acids for immediate use within hours. As a result, researchers developing new assays can save days, sometimes even weeks, by printing in-house versus waiting for oligos to be delivered from third-party service providers. This capability is critically important for programs focused on improving the response time to emerging biological risks and biothreats.

Financial terms were not disclosed.

About DNA Script

Founded in 2014, DNA Script is a pioneering life sciences technology company developing a new, faster, more powerful and versatile way to design and manufacture nucleic acids. The company has developed an alternative to traditional DNA synthesis called Enzymatic DNA Synthesis, or EDS, enabling this technology to be accessible to labs with the first benchtop enzymatic synthesis instrument, the SYNTAX System. By putting DNA synthesis back in the lab, DNA Script aims to transform life sciences research through innovative technology that gives researchers unprecedented control and autonomy. http://www.dnascript.com

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French Defense Innovation Agency Investigates the Use of DNA Script's SYNTAX System to Synthesize Custom qPCR Probes for On-demand Detection of...

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Sony’s Vampire Movie ‘The Invitation’ Shows the Dangers of DNA Testing – Pajiba Entertainment News

Posted: at 12:38 am

Im of the opinion that genetic testing to find your ancestral background and lost relatives is a Bad Idea. For one thing, whichever company you use owns that information. They sell it to pharmaceutical companies. They hand it over to law enforcement. They store it in online databases ripe for hacking. Plus, I dont care for most of the relatives I grew up around. Why would I want to know about others?

But orphan Evie (Nathalie Emmanuel, Ramsey from the Fast & Furious franchise) thinks the answer to her loneliness is family (HA!). So she sends off her DNA to a testing service and discovers shes related to English aristocrats. They invite her overseas to attend a family wedding and things get weird.

Note: The trailer is spoiler-heavy, and I recommend opting out after the first slit throat.

The Invitation looks fun if a little heavyhanded on the allegory. We get it, the 1% are literal vampires sucking the life from society. But I appreciate that the protagonist is a person of color. It adds another layer to the interactions between poor American and wealthy Brits. The movie feels very like 2019s Ready or Not, a personal favorite; I hope its more inspired by than derivative. That being said, my hopes for the heroine are slim. If you cant figure out the spooky rich guy named Walter DeVille is evil, well, your chances of survival are that of an old horse in a glue factory.

The Invitation is directed and written by Jessica M. Thompson, known for The Light of the Moon and The End, and also written by Blair Butler (Helstrom). It hits theaters this August 26.

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