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Category Archives: Transhuman News

Why humans should go to Mars and other places in space

Posted: January 20, 2015 at 12:46 am

Reusable, modular space systems could make human Mars missions more affordable and eliminate one long-running objection to them. (credit: J. Strickland)

In a recent op-ed published in the Richmond (Va.) Times-Dispatch, titled Why humans shouldnt go to Mars, University of Virginia biology professor Michael Menaker argues that human exploration of Mars doesnt make good sense. We are already exploring Mars with robotic spacecraft, he states, and there are urgent Earth-bound problems to solve.

However, he has not made his case, which is based on several wrong fundamental assumptions. Its possible he may be reacting to the blatant Mars Hype that was recently put out by some people within NASA who support the SLS and Orion programs, since the article does mention the Orion test launch. What the article really represents, however, is the zero sum game attitude by a few within the science community, some of whom depend on government science programs for their employment. I must emphasize that this point is not meant to denigrate the vast majority of scientists, many of whom work on valid and important research and struggle every year to maintain their labs financial survival. I suspect the majority of those who work on robotic spacecraft programs do strongly support the human space program, but those who do not sometimes get more media attention when they speak out, since taking such a position is controversial. Their attitude is that funding for a human Mars mission would take money away from their science. What Menaker forgets is that any human spaceflight program uses funding that could possibly go to the robotic or pure science programs instead, so that opposition to Mars programs is also in effect opposition to all human spaceflight. His comments later in the essay, about urgent Earth-bound problems, confirm that this is his position.

In my view, both robotic and human programs are both important and interdependent. The robotic program gets part of its support from interest in future human exploration, while that future human program will rely heavily on the data from the robotic programs to determine good landing sites and allow safe landings. As a very strong supporter of science in general, and space science and planetology in particular, I find it sad that some people have such a limited vision of how tightly linked science and exploration are. Professor Menaker works at the University of Virginia, whose first president was Thomas Jefferson. As US President, Jefferson sent the Lewis and Clark expedition across two-thirds of a continent and back. That expedition contributed tremendously to understanding the geography and biology of the American West. In like manner, future exploration of Mars by robots and humans will help us understand planets in general, even our own Earth. The exhortation by Menaker to stay home on the Earth would, if followed, greatly impede both our ability to understand the Earth and to protect it.

Menaker agonizes over the stress on crews on such long voyages, but these are nothing new, and in turn will contribute greatly to humanitys future. Previously, several nations, such as Portugal, Spain, and England, have sent crews of sailors on very long voyages of exploration, some lasting for three years, as long as a Mars expedition would last (just getting to Mars takes six to eight months.) The results of these voyages included finding an economical route to the Far East around Africa, proving yet again that the world was round by circumnavigation, and the discovery of Australia and the Hawaiian Islands. Furthermore, expeditions to Mars will be in constant contact with their families on Earth, even though there will be a time delay. The isolation and stress of a Mars mission will be nothing like such maritime crews withstood, in an age before good food and good health could be provided at sea.

Menakers take on the high cost of Mars expeditions and the risk to astronauts is also based on wrong and outdated assumptions. With current and past technology, as represented by the expendable SLS booster and Orion programs, the cost, the risk to crews, and the potential radiation doses would in fact be very high. If Mars missions were mounted using the current NASA plans, the cost would probably be in the hundreds of billions of dollars and radiation doses could exceed current lifetime safety limits. However, it is very unlikely that such huge amounts would ever be approved by Congress, and since just one of the unmanned programs, the James Webb Space Telescope, will cost almost $10 billion all by itself, complaining about only the current human space budget seems misplaced. It is also worth pointing outfor probably the millionth timethat the entire NASA budget is one half of one percent of the federal budget. All of the existing social programs vastly outspend it.

So it is much more likely that Mars expeditions will actually be conducted with reusable boosters and reusable spacecraft designed and built by private companies. Much of the space community is coming to share this view. In addition to reducing the cost, such boosters will allow the use of heavy and effective radiation shielding on the crew habitats, making the radiation issue moot. By the time we are ready for Mars expeditions, sometime after 2025, such boosters and spacecraft will be operating.

With these, a continuing program of Mars exploration will be possible within annual NASA budget limits. The cost of an initial human NASA Mars program would probably be in the tens of billions of dollars, but that is trivial compared to the vast sums spend on the inefficient shuttle program. The more that private companies are involved, the lower the cost will be. If the cost is shared by developing standardized vehicles to also support a lunar base, the overall cost will be lower still. In any case, total costs of a program are misleading, since it is the annual cost that is more important to an exploration program run by a government. Over a 15-year time framefive years for development and ten years for operationsthe cost of a $30-billion program would be roughly comparable to what is now being wasted on the SLS.

A program will also not run out of vehicles quickly if they are all designed for reuse, so the program can be continued at a lower cost. With a robust Mars mission architecture, the issue of whether crew members stay at Mars or come home after one expedition becomes moot. Since the vehicles that would take crew members to Mars are reusable, we would want them back at Earth to use for another expedition. This means at least some of the crew members would return after the first expedition was over. The high amounts of mass that a robust mission can land on the surface would allow other crew members to remain on Mars and augment the next crew to arrive, with food and supplies sufficient for many years. A larger crew would provide more hands to do work such as enlarging the base and its pressurized habitat volume. Thus a flexible policy on who returns and who stays could allow a larger crew to do useful work at a Mars science base with each succeeding mission.

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Why humans should go to Mars and other places in space

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OMD Genetic Engineering – Saturday Superstore – Video

Posted: at 12:45 am


OMD Genetic Engineering - Saturday Superstore
Here we have a very old and rare clip of Orchestral Manoeuvres in the Dark on the Saturday Superstore and they are doing Genetic Engineering.

By: Neil Taylor

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OMD Genetic Engineering - Saturday Superstore - Video

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'Molecular scissors' could prevent genetic diseases before conception

Posted: at 12:45 am

15 hours ago by Vicky Just The technique can edit DNA at the point of fertilisation, speeding up the process of genetic research

Scientists from our Department of Biology & Biochemistry have developed a new technique that will streamline biomedical research and could in the future prevent genetic diseases before the moment of conception.

In a study published in the Nature Group journal Scientific Reports, the scientists used 'molecular scissors' that can edit the DNA of either the egg or sperm of mice during fertilisation.

The researchers used the enzyme Cas9 to cut a precise point in the genome, enabling them accurately to inactivate a specific gene. This allows scientists to study specified gene function in mice by creating a 'knock-out' in closer to one month rather than the six required using conventional techniques.

This powerful tool should accelerate biomedical research and promises to reduce the number of animals used in experiments to answer fundamental medical questions.

Dr Tony Perry, the study's senior author at the University's Laboratory of Mammalian Molecular Embryology, explained: "We're really excited about this research. Previously, this technique had been demonstrated with established embryos but we've shown that we can accurately edit genes in the sperm or egg around the time of fertilisation, just as the embryo is starting to develop.

"Cas9 works by cutting the DNA at a precise point in the genome. The cell repairs this cut but chews the frayed ends before rejoining them, destroying the function of the gene.

"The technique has many exciting potential applications. It could help to provide disease resistance to livestock or perhaps provide a method for preventing serious genetic conditions in humans at the point of conception - for example by allowing carriers of life-threatening genetic conditions such as cystic fibrosis to conceive healthy babies without the risk of passing on the disease."

Researchers anticipate that the method could also be used to enable the transplant of organs of some large animals into humans without the problem of rejection, by making the organs immunologically invisible.

Dr Perry added: "This is a dream for transplant surgeons and patients awaiting immunologically matched organs. It means that one day it may be possible to transplant these engineered organs - even if only until a suitable human one is found - and save lives."

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'Molecular scissors' could prevent genetic diseases before conception

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Annunaki, Elohim and Human Genetics: Basis, Bias, or BS? Please Share! – Video

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Annunaki, Elohim and Human Genetics: Basis, Bias, or BS? Please Share!
This video covers the HARD SCIENCE behind the properties observed in DNA and various aspects of the Origins of Life. We will cover various concepts of geneti...

By: Cullen Smith Lifting The Veil

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Genetics underpinning antimalarial drug resistance revealed

Posted: at 12:45 am

Largest genome-wide study of parasite provides clearest picture yet of genetic changes driving artemisinin resistance

The largest genome-wide association study to date of the malaria parasite Plasmodium falciparum unveils a complex genetic architecture that enables the parasite to develop resistance to our most effective antimalarial drug, artemisinin. The results could help to improve early detection of emerging artemisinin resistance.

The global research collaboration analysed 1612 samples from 15 locations in Southeast Asia and Africa finding 20 mutations in the kelch13 gene, a known artemisinin resistance marker, that appear to work in concert with a set of background mutations in four other genes to support artemisinin resistance.

"Our findings suggest that these background mutations emerged with limited impact on artemisinin resistance -- until mutations occurred in the kelch13 gene," explains Dr Roberto Amato, a first author and Research Associate in Statistical Genomics at the Wellcome Trust Sanger Institute and Oxford University's Wellcome Trust Centre for Human Genetics. "It's similar to what we see with pre-cancerous cells which accumulate genetic changes but only become malignant when they acquire critical driver mutations that kick-off growth."

The variety of kelch13 mutations associated with artemisinin resistance, with new variants continually emerging, makes it difficult to use this gene alone as a marker for genetic surveillance.

Monitoring parasite populations for a specific genetic background - in this case, a fixed set of four well-defined mutations in the fd, arps10, mdr2, and crt genes - could allow researchers to assess the likelihood of new resistance-causing mutations emerging in different locations, helping to target high-risk regions even before resistant parasites take hold.

"We are at a pivotal point for malaria control. While malaria deaths have been halved, this progress is at risk if artemisinin ceases to be effective," says Nick Day, Director of the Mahidol-Oxford Tropical Medicine Research Unit (MORU) in Bangkok, Thailand. "We need to use every tool at our disposal to protect this drug. Monitoring parasites for background mutations could provide an early warning system to identify areas at risk for artemisinin resistance."

Researchers also uncovered new clues about how artemisinin resistance has evolved in Southeast Asia. By comparing parasites from Cambodia, Vietnam, Laos, Thailand, Myanmar and Bangladesh, scientists found that the distribution of different kelch13 mutations are localised within relatively well-defined geographical areas.

Whilst artemisinin resistant parasites do appear to have migrated across national borders, this only happened on a limited scale and, in fact, the most widespread kelch13 mutation, C580Y, appeared to have emerged independently on several occasions. Notably parasites along the Thailand-Myanmar border appear to have acquired this mutation separately from those in Cambodia and Vietnam. Crucially, parasite populations in both regions possess the genetic background mutations, even though they are clearly genetically distinct.

There remain many unanswered questions. "We don't yet know the role of these background mutations," says Dr Olivo Miotto, a first author and Senior Informatics Fellow at MORU and the Centre for Genomics and Global Health. "Some may not affect drug resistance directly, but rather provide an environment where drug resistance mutations are tolerated. Since kelch13 has hardly changed in 50 million years of Plasmodium evolution, we can assume that this gene is essential to parasite survival. Therefore, kelch13 mutations may severely handicap mutant parasites, compromising their survival unless some other change can counteract this negative effect."

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Genetics underpinning antimalarial drug resistance revealed

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DNA 11 – Video

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DNA 11
Call of Duty Advanced Warfare https://store.sonyentertainmentnetwork.com/#!/tid=CUSA00803_00.

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DNA Reiners w Michelle Epps w Bridge Church Columbus #bebraver – Video

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DNA Reiners w Michelle Epps w Bridge Church Columbus #bebraver

By: Donna Reiners

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Call of Duty: Advanced Warfare AlMOST a DNA so mad – Video

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Call of Duty: Advanced Warfare AlMOST a DNA so mad
So mad dudes subscribe for more Call of Duty: Advanced Warfare https://store.sonyentertainmentnetwork.com/#!/tid=CUSA00803_00.

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Road to DNA: Episode 1 – Video

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Road to DNA: Episode 1
I have not yet named this video.

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Road to DNA: Episode 1 - Video

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DNA BOMB FAIL – Video

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DNA BOMB FAIL
Add me NoYP-K3Nz SHAREfactory https://store.sonyentertainmentnetwork.com/#!/tid=CUSA00572_00.

By: Kenechu KSL

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DNA BOMB FAIL - Video

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