Category Archives: Transhuman News

7 Day Genome DNA Stemcell Healing - Self Help/Practitioner Certification
To learn more about this healing method go to http://www.genomehealing.com or http://www.genomehealing.com.au.

By: Gabi Bliss

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7 Day Genome DNA Stemcell Healing - Self Help/Practitioner Certification - Video

DaiDai Genome AR11 [DT HD]

By: Ole Zhang

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DaiDai Genome AR11 [DT HD] - Video

CRISPR technology for genome editing
CRISPR, a pioneering genome-editing technique, technology will allow AstraZeneca to identify and validate new drug targets in preclinical models that closely resemble human disease.

By: astrazeneca

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CRISPR technology for genome editing - Video

NCI Press Release

Investigators with The Cancer Genome Atlas (TCGA) Research Network have discovered genomic differences with potentially important clinical implications in head and neck cancers caused by infection with the human papillomavirus (HPV). HPV is the most common sexually transmitted virus in the United States, and the number of HPV-related head and neck cancers has been growing. Almost every sexually active person will acquire HPV at some point in their lives, according to the Centers for Disease Control and Prevention.

The researchers also uncovered new smoking-related cancer subtypes and potential new drug targets, and found numerous genomic similarities with other cancer types. Taken together, this studys findings may provide more detailed explanations of how HPV infection and smoking play roles in head and neck cancer risk and disease development, and offer potential novel diagnostic and treatment directions.

The study is the most comprehensive examination to date of genomic alterations in head and neck cancers. The results were published online Jan. 28, 2015 in the journal Nature. TCGA is jointly supported and managed by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both parts of the National Institutes of Health.

The U.S. Food and Drug Administration-approved HPV vaccines should be able to prevent the cancers caused by HPV infection in head and neck cancers and elsewhere, including anal cancer, whose incidence has also been increasing. However, these vaccines work by preventing new infections, and the long interval between infection and cancer development make it important to understand the molecular changes that bring about these HPV-positive head and neck cancers as well as those that lead to the HPV-negative cancers - and to develop new approaches for treating them.

The rapid increase in HPV-related head and neck cancers, noticeably in oropharyngeal tumors, has created an even greater sense of urgency in the field, said D. Neil Hayes, M.D., M.P.H, senior author of the study report and associate professor of medicine at the University of North Carolina (UNC) and the UNC Lineberger Cancer Center at Chapel Hill. Oropharyngeal cancer starts in the oropharynx, which is the part of the throat just behind the mouth. Were uncovering differences between tumors with and without HPV infection, and these new data are allowing us to rethink how we approach head and neck cancers.

In the study, researchers performed genomic analyses on 279 tumors head and neck squamous cell carcinomas (HNSCC) from untreated patients. Approximately 80 percent of tumor samples were from individuals who smoked. The majority of samples were oral cavity cancers (61 percent) and larynx cancers (26 percent).

While only about 25 percent of head and neck cancers are linked to HPV infection, TCGA researchers confirmed that many patients with HPV-associated tumors have specific alterations of the gene FGFR3 and mutations in the PIK3CA gene, which are also found in a much broader set of mutations in smoking-related tumors. In contrast, while the EGFR (epidermal growth factor receptor) gene is frequently altered in HPV-negative tumors in smokers, it is rarely abnormal in HPV-positive tumors. Such insights may help in developing potential therapies and biomarkers, noted Dr. Hayes.

Head and neck cancers comprise a constellation of tumors of the mouth, throat, larynx, nasal cavity, salivary gland and elsewhere that have frequently been attributed to tobacco and alcohol use in most patients. Some 90 percent are squamous cell carcinomas, which occur in the surface layers of cells in the body. An estimated 55,000 people developed head and neck cancer in the United States in 2014. Approximately 12,000 Americans die from the diseases each year. Head and neck cancers are common worldwide, with more than 600,000 cases diagnosed each year.

The rising worldwide incidence of head and neck cancers makes these types of large integrated genomic analyses by TCGA vital to establish a more detailed understanding of disease causes and behavior, and for the development of new treatment approaches, said NIH Director Francis S. Collins, M.D., Ph.D.

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NIH-funded study uncovers range of molecular alterations in head and neck cancers, new potential drug targets; TCGA ...

Mouat Grade 9 science student Kirsten Spitzig transfers a sample of Kiwi DNA during a school visit by Genome BCs Geneskool program.

image credit: Tyler Olsen

Secondary students in Abbotsford got a peak inside the world of genomics and genetics when Genome BCs Geneskool program visited science and biology classes at local secondary schools earlier this week.

Students at WJ Mouat secondary school and Dasmesh Punjabi School worked to solve a fun mystery involving a rich father, a kidney donation, and a child who was switched at birth in a hospital.

The students learned about genomes, DNA and how researchers use them in the lab.

Genomics is an information science that is increasingly becoming more important as every living organism on the planet has a genome.

The Genome BC Geneskool volunteers, scientist presenters from UBCs Lets Talk Science program, are often MSc and PhD candidates who share their motivation and passion for science with the students.

The Genome BC Geneskool programs have been active in communities throughout the province for almost a decade. The program also shares science in a mobile fashion with creative Genome BC Geneskool "travelling suitcase exhibits" full of portable displays and hands on activities and materials.

Molecular biology is an integral part of our natural world, said Sally Greenwood, vice-president of communications and education at Genome BC. The Genome BC Geneskool program offers students a chance to use advanced laboratory technology and techniques to see the tiny world that exists at the microbial level while learning, having fun and garnering a greater appreciation of the world around us.

I dont think we can underestimate the need to promote science to the next generation, said Dr. Alan Winter, president and chief executive officer of Genome BC.

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Geneskool visits Abbotsford schools