Category Archives: Transhuman News

Red Recruitment Challenge, New Videos, Spring Break! (AW Double DNA Bomb)
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Red Recruitment Challenge, New Videos, Spring Break! (AW Double DNA Bomb) - Video

DNA Bomb in One Shot? (FFA)
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DNA Bomb in One Shot? (FFA) - Video

DNA Replication-Western Addition

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DNA Replication-Western Addition - Video

Call of Duty: Advanced Warfare DNA Bomb Fail... New YouTube, New Beginnings
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AW DNA Fail | Freestyle Commentary
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AW DNA Fail | Freestyle Commentary - Video

INSANE DNA GAMEPLAY
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INSANE DNA GAMEPLAY - Video

ST. PAUL, Minn. (AP) The body of a woman found in a drainage ditch 35 years ago has been identified as that of an 18-year-old Texas hitchhiker who was assaulted and killed by a former Minnesota state trooper, state authorities said Tuesday.

Michelle Yvette Busha's remains were identified over the weekend through DNA testing. Her body was found on May 30, 1980, and had been buried anonymously at a cemetery in the southern Minnesota city of Blue Earth for the past three decades.

Robert Leroy Nelson, a state trooper at the time, had confessed to killing a woman nine years later, but investigators had been unable to determine her identity.

"This was a case of not whodunit, but who was she," said Faribault County Sheriff Michael Gormley.

Busha's remains were exhumed in August and DNA was collected as part of a Minnesota Bureau of Criminal Apprehension effort to identify dozens of unidentified human remains in the state.

BCA Forensic Science Services Director Catherine Knutson said investigators built a DNA profile, and entered that information into a national database for missing persons in mid-February. The results matched DNA samples submitted by members of Busha's family in 2007.

"Michelle's family has experienced a terrible loss, but they now have answers about what has happened to their daughter," Gormley said, adding that her family was surprised to learn she was in Minnesota.

Jerry Kabe, former chief deputy sheriff in Faribault County and a former lead investigator on the case, said Nelson was being questioned in the sexual assault of a child in Texas when he admitted to killing an unidentified woman in Minnesota. Nelson was convicted in both cases and remains in prison, authorities said.

Kabe said Nelson told investigators he was watching traffic when a dark van let a young woman out. He followed her, put her in his car, and sexually assaulted, handcuffed and tortured her. He then strangled the woman with a cord, and left her body in a ravine near Interstate 90, east of Blue Earth.

Busha's family reported her missing in Texas on May 9, 1980. The body was found weeks later.

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DNA identifies woman slain by Minnesota trooper in 1980

Schenectady

The latest forensic science has not been working in John Wakefield's favor.

The inventor of a new computer-assisted DNA technology testified on Tuesday that DNA matching that of Wakefield, the defendant in a murder case, was found on the amplifier cord used to fatally choke 41-year-old Brett Wentworth as well as on the victim's forearm and shirt collar.

Mark Perlin, the creator of Cybergenetics True Allele Casework and the prosecution's star witness against Wakefield, 48, talked jurors through a PowerPoint slide presentation detailing the astronomical odds against the DNA he analyzed belonging to anyone other than Wakefield.

Schenectady County prosecutors say Wakefield killed Wentworth in the victim's home on Wendell Avenue in April 2010, using the amplifier cord.

Perlin compared the DNA found on the amplifier cord to Wakefield using his technology, which he developed over 10 years and with 25 different versions.

It uses mathematical formulas to pinpoint individual human DNA on an item that may have been touched by many people.

Perlin's estimates, which covered Caucasians, blacks and Hispanics, said the odds of the DNA belonging to someone else were all but impossible.

Perlin said a match between Wakefield and the DNA was 300 million times more probable than a coincidental match to an unrelated Caucasian; 2.25 billion times more probable than a coincidental match to an unrelated Hispanic person; and 5.88 billion more probable than a coincidental match to an unrelated black person.

During cross-examination, defense attorney Frederick Rench said that lengthy parts of the cord did not contain his client's DNA.

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DNA expert links man to Schenectady murder

To pack two meters of DNA into a microscopic cell, the string of genetic information must be wound extremely carefully into chromosomes. Surprisingly the DNA's sequence causes it to be coiled and uncoiled much like a yoyo, scientists reported in Cell.

"We discovered this interesting physics of DNA that its sequence determines the flexibility and thus the stability of the DNA package inside the cell," said Gutgsell Professor of Physics Taekjip Ha, who is a member of the Carl R. Woese Institute for Genomic Biology at the University of Illinois. "This is actually very elementary DNA physics. Many people thought we should have known this many decades ago, but there are still surprises in the physics of DNA."

The DNA is packaged into chromosomes, which resemble beaded bracelets. The string of DNA is coiled around beads, called histones, to create nucleosomes. These nucleosomes are braided together into beaded strings that are intricately woven into chromosomes.

Scientists knew the DNA could be uncoiled from the nucleosome, but it was assumed that the two ends were symmetric, meaning uncoiling the DNA would be like untying a shoe. University of Illinois researchers found that the DNA is actually very asymmetric, like the string wrapped around a yoyo. Pulling on one end of DNA will simply tighten the coil while pulling on the other will cause it to uncoil like a yoyo.

The physics of this nucleosome packaging is determined by the DNA's sequence, which makes the strand of DNA flexible enough to satisfy two conflicting principles: it has to be stable enough to compact DNA, but dynamic enough so the strand can be uncoiled and read to make proteins.

"There are many good studies that show that if you change the sequence of the gene, then it will affect other things. Different proteins may be created because they require certain sequences for binding and so on," said Ha. "But no one had really thought about sequence changes having an effect on DNA physics, which in turn cause changes in the biology."

Ha's research has shown that it is easier for the cell's protein-making machinery to read from the "weak" end of the nucleosome that uncoils more easily. They believe that genetic mutations related to diseases, like cancer, alter the stability of the nucleosome.

"This could have a major impact on how the information is read out and how different proteins are produced," Ha said. "For example, cancer-fighting proteins or cancer-causing proteins may be made differently depending on the changes in DNA flexibility and stability caused by mutations."

Next Ha plans to use next generation sequencing to determine the flexibility of an entire genome. He hopes to create the first genome-wide map of physical properties. He also wants to find out if mutations can make the DNA easier or more difficult to read.

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DNA is packaged like a yoyo, scientists find

A group of Russian and South Korean researchers has begun their attempt to clone a woolly mammoth, starting by extracting DNA from a spectacularly well-preserved specimen discovered in the Siberian permafrot in 2013. The project is led by Hwang Woo-Suk, a Korean cloning scientist who was the focus of a scandal in 2006 involving fraudulent research on human stem cells. Hwang has had success with animals, however, reportedly creating the world's first cloned dog and several cloned coyotes.

The research team, from the Sooam Biotech Research Foundation and Russia's North-Eastern Federal University, began this week to extract DNA from the leg of the long-frozen animal. The news was reported by the university and the Siberian Times.

Note: Video is in Korean and Russian, but subtitles can be roughly auto-translated in the 'settings' box of the player.

"We take samples of bone marrow it is one of the best materials for DNA analysis," explained Semyon Grigoriev, director of the Mammoth Museum in Yakutsk, where scientists gathered this week to examine the remains. "If the samples are good then our coordinated work, I think, will allow in a year or two to decipher the world's first nuclear genome of the mammoth," he continued.

If no complete cells can be found to resuscitate, mapping the genome is a critical step in the process of cloning the long-extinct animal by creating an artificial cell nucleus. It is, however, nowhere near the end of potential difficulties for the ambitious program the reconstructed DNA would have to be successfully transplanted in a living elephant embryo and carried to term.

First published March 16 2015, 3:26 PM

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Scientists Tap Mammoth Leg's DNA for Cloning Project