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Category Archives: Transhuman News
CoD Advance Warfare Spawn Trap DNA Bomb – Video
Posted: March 26, 2015 at 10:47 am
CoD Advance Warfare Spawn Trap DNA Bomb
Nuestro fan Nathaniel1216 nos enva un video de un spawn trap jugando uplink.
By: Gamers el Movimiento Oficial
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CoD Advance Warfare Spawn Trap DNA Bomb - Video
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DNA samples gathered from rare DeKalb quad calves, cow
Posted: at 10:47 am
DEKALB, TX (KSLA) -
DNA samples have been taken from the 4 calves born to a DeKalb, TX cow last week.
Veterinarian Dr. Michael Baird says the parentage testing was arranged in order to put to rest any doubts that the calves are siblings born to the same cow.
Click here to see new photos from the DNA sampling of the cow and her calves.
Those doubts are not surprising, considering births with 4 surviving calves like this are estimated to be more than one in 11 million.
News of the calves birth has been reported the around the country and the world, including Japan.
"Both the owners and I have full faith that these quads are legitimate. I have no reason to believe otherwise. However, in the interest of science and the animal industry, we have decided to leave nothing to speculation," Baird said on his Facebook page Tuesday.
Tissue samples were taken Tuesday from each of the calves' ears and their mother by GeneSeek, a Nebraska-based biotechnology company specializing in genetics, identity and trait determination.
Baird himself had his doubts when he first learned of the rare birth. He says he the owners, Dora and Jim Barling, came to his clinic the day the calves were born with a picture and told him their cow had just delivered quadruplets.
"I was immediately suspicious that one or 2 of these calves belonged to another cow. I have seen ranchers as well mama cows themselves become confused as to which calves belong to which cows."
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Mobile DNA sequencer shows potential for disease surveillance
Posted: at 10:47 am
A pocket-sized device that can rapidly determine the sequence of an organism's DNA has shown its potential in disease detection, according to a study published in the open access, open data journal GigaScience
IMAGE:This is a close up of MinION. view more
Credit: Andrew Kilianski
A pocket-sized device that can rapidly determine the sequence of an organism's DNA has shown its potential in disease detection, according to a study published in the open access, open data journal GigaScience.
In the first analysis of its kind, researchers were able to use the device to accurately identify a range of closely-related bacteria and viruses within six hours, demonstrating the potential for this technology to be used as a mobile diagnostic clinic during outbreaks.
The MinION 'Nanopore sequencer' is a low-cost palm-sized sequencing device from Oxford Nanopore Technologies that has been made available to some research groups for testing. It is powered and operated via a USB connection plugged into a laptop, which means that it could potentially be used for on-site clinical analyses in remote locations, negating the need for samples to be sent off to laboratories.
Lead author Andrew Kilianski from Edgewood Chemical Biological Center, USA, whose team tested the device in joint collaboration with Signature Science, LLC, said: "Our findings are important because we have for the first time communicated to the community that this technology can be incredibly useful in its current state.
"Being able to accurately identify and characterize strains of viruses and bacteria using a mobile platform is attractive to anyone collecting biological samples in the field. And we expect that as the technology improves, the sequencing will generally become cheaper, faster and more accurate, and could have further clinical applications."
The researchers were able to use the MinION to accurately identify and differentiate viral and bacterial species from samples. Within six hours, the device generated sufficient data to identify an E. coli sample down to species level, and three poxviruses (cowpox, vaccinia-MVA, and vaccinia-Lister) down to strain level. The device was able to distinguish between the two vaccinia strains despite them being closely related and over 98% similar to each other.
The technology relies on protein 'nanopores' to determine the sequence of a strand of DNA. At the core of the protein is a hollow tube only a few nanometres in diameter, through which a single DNA strands can pass. As the DNA strand passes through the nanopore, it causes characteristic electrical signatures, from which bases can be identified, and the sequence of the strand determined.
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Mobile DNA sequencer shows potential for disease surveillance
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Applied DNA Sciences and Divatex Sign Agreement to Commercialize the World's First Supply Chain-DNA-Verified Cottons
Posted: at 10:47 am
STONY BROOK, NY--(Marketwired - March 25, 2015) - Applied DNA Sciences, Inc. (NASDAQ: APDN) (Twitter: @APDN), a provider of DNA-based anti-counterfeiting technology, supply chain and product authentication solutions, has entered into a mutual license agreement with Divatex, a leading supplier of home textiles, to commercialize the world's first supply-chain-DNA-verified cotton product. Divatex is responsible for marketing, while APDN licenses its patented SigNature T DNA technology for application to ensure the veracity of the product. Divatex is a wholly-owned subsidiary of Himatsingka Group, India.
"We are excited to use this amazing new innovation to help us deliver a verified, undiluted and authentic proposition to the consumer. It has become increasingly important to our customers that they understand what it is that they are buying, and trust they are getting what they paid for," said David Greenstein, CEO of Divatex.
Using APDN's patented SigNature T DNA technology, US-grown cotton fibers were DNA-tagged at the ginner, enabling all nodes of the supply chain to verify purity along the way. Earlier this year bulk quantities of this year's pima harvest have undergone SigNature T DNA tagging in the San Joaquin Valley in California.
The first finished product made from this tagged fiber will be offered for sale across the US later this year under the PimaCott content-branded label.
In addition, APDN expects to license its "On-Site" DNA authentication technology to the suppliers within this retailer's supply chain. Traceability, and authenticity of the cotton supply will be verified as the cotton evolves into finished goods.
Dr. James A. Hayward, CEO of APDN, commented: "The arrangement with Divatex is strategic, retailer-driven, providing the incentive for all supply chain members to participate. Together, we will deliver an unmatched value proposition to retail and consumers in exchange for a new revenue stream from licensing of our core DNA marking technology and our On-Site DNA Authentication services. We will be meeting with many industry brands to demonstrate the platform during NYC market week in which commitments are made for the coming harvest."
About Applied DNA Sciences We make life real and safe by providing botanical-DNA based security and authentication solutions and services that can help protect products, brands, entire supply chains, and intellectual property of companies, governments and consumers from theft, counterfeiting, fraud and diversion.SigNature DNA describes the platform ingredient that is at the heart of all of our security and authentication solutions.SigNature DNA is at the core of a family of uncopyable products such as DNAnet, our anti-theft product, SigNature T, targeted toward textiles, and digitalDNA, providing powerful track and trace. All provide a forensic chain of evidence and can be used to prosecute perpetrators.
Applied DNA Sciences common stock is listed on NASDAQ under the symbol APDN, and its warrants are listed under the symbol APDNW.
Forward-Looking StatementThe statements made by APDNin this press releasemay be"forward-looking"in naturewithin the meaning of the Private Securities Litigation Act of 1995.Forward-looking statements describe APDN's future plans, projections, strategies and expectations, and are based on assumptions and involve a number of risks and uncertainties, many of which are beyond the control of APDN. Actual results could differ materially from those projected due to our short operating history, limited financial resources, limited market acceptance, market competition and various other factors detailed from time to time in APDN's SEC reports and filings, including our Annual Report on Form 10-K filed onDecember 15, 2014, as amended on March 6, 2015, and our subsequent quarterly report on Form 10-Q which are available atwww.sec.gov. APDN undertakes no obligation to update publicly any forward-looking statements to reflect new information, events or circumstances after the date hereof to reflect the occurrence of unanticipated events, unless otherwise required by law.
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Applied DNA Sciences and Divatex Sign Agreement to Commercialize the World's First Supply Chain-DNA-Verified Cottons
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Ravenswood murder victim's DNA found at home of accused man Marco Rusterholz
Posted: at 10:47 am
DNA from a murder victim was detected on a fuel can found at the home of the accused man, a Supreme Court jury in Launceston has heard.
Marco Daniel Rusterholz pleaded not guilty to the 2012 murders of Angela Hallam and Joshua Newman in a Ravenswood unit.
The crown alleged he stabbed the pair to death and then set fire to their bodies using petrol, motivated by a drug debt and a desire to please his new girlfriend.
Forensic scientist Dr Cory Griffiths conducted DNA profiles on samples found at the crime scene as well as items seized by police from Rusterholz's home.
He told the court Newman was the major contributor to DNA found on parts of a fuel can that were recovered by police from a shed at Rusterholz's home.
Dr Griffiths said there was a "one-in-one-billion" chance of the DNA matching a random person who was not Newman.
Earlier the trial heard human blood was detected on the fuel can.
Dr Griffiths said samples from a later examination of the back of the fuel can contained DNA from Rusterholz.
The trial also heard one of the victims was stealing drugs from the accused.
Matthew James Coventry told the jury he and Angela Hallam had sold boxes of morphine around the state, which the accused had supplied.
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Thief's DNA found on pair of pliers left at scene
Posted: at 10:47 am
North Staffordshire Justice Centre in Newcastle
THIEF William Lockley was caught after breaking into a shop when his DNA was found on a pair of pliers.
DNA taken from a pair of pliers found at a shop which had been burgled, led officers to arrest William Lockley.
North Staffordshire Justice Centre heard the owner of the Butty Box, in Uttoxeter Road, Longton, found the door had been damaged and a security camera and jar of loose change was missing when she arrived at work.
Steve Knowles, prosecuting, said the owner discovered a pair of pliers, which didn't belong to her.
He said DNA from them led police to Lockley, of no fixed address, was arrested when his DNA matched but refused to comment . The defendant declined to comment when he was interviewed.
He later pleaded guilty to that between March 7 and March 9 this year at Longton, he entering as a trespasser the Butty Box as a trespasser and stealing the camera and change together worth 500.
The defendant also asked for an offence of stealing five sirloin steaks, four rump steaks and three lamb steaks worth 75 from the Co-op, Normacot, to be taken into consideration. He was jailed for a total of 16 weeks.
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Icelandic genome offers clues to human diversity, gene-disease links
Posted: at 10:47 am
Scientists who sequenced the entire genomes of 2,636 people in Iceland have produced a trove of information about the nature, location, and frequency of human genetic variations.
The new research not only sheds light on the range of human genetic variability; it helps equip researchers to draw more direct lines between genes and diseases.
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FOR THE RECORD
A previous version of this story said the director of the Genetic Variation Program at the National Human Genome Research Institute was Linda D. Brooks. She is Lisa D. Brooks.
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In a package of articles published Wednesday in the journal Nature Genetics, a private consortium of researchers found genetic abnormalities long thought to doom their host to early death to be more common than has been believed. They also discovered new genetic contributors to such varied afflictions as Alzheimer's disease, liver disease and atrial fibrillation.
The effort, underwritten by Amgen's DeCode Genetics, a biopharmaceutical company based in Reykjavik, Iceland, offers scientists insight to the human genome that will expand their ability to investigate the genetic bases of human diseases.
By sequencing the full genomes of more than 2,500 Icelanders and comparing the results with less extensive genotype data from more than 104,000 other Icelanders, the teams identified more than 20 million genetic variants in the Icelandic population.
They then cross-checked that information against Iceland's extensive genealogical and healthcare information records, which would document diagnoses, chronicle treatment response and allow researchers to see how a single disease might run through generations of a given family.
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Genome Study Predicts DNA of the Whole of Iceland
Posted: at 10:47 am
Large genome databases are starting to reveal critical health informationeven about people who have not contributed their DNA.
Maps show how common certain risk-causing DNA mutations are around Iceland.
The CEO of an Icelandic gene-hunting company says he is able to identify everyone from that country who has a deadly cancer risk, but has been unable to warn people of the danger because of ethics rules governing DNA research.
The company, DeCode Genetics, based in Reykjavk, says it has collected full DNA sequences on 10,000 individuals. And because people on the island are closely related, DeCode says it can now also extrapolate to accurately guess the DNA makeup of nearly all other 320,000 citizens of that country, including those who never participated in its studies.
Thats raising complex medical and ethical issues about whether DeCode, which is owned by the U.S. biotechnology company Amgen, will be able to inform members of the public if they are at risk for fatal diseases.
Kri Stefnsson, the doctor who is founder and CEO of DeCode, says he is worried about mutations in a gene called BRCA2 that convey a sharply increased risk of breast and ovarian cancers. DeCodes data can now identify about 2,000 people with the gene mutation across Icelands population, and Stefnsson saidthat the company has been in negotiations with health authorities about whether to alert them.
We could save these people from dying prematurely, but we are not, because we as a society havent agreed on that, says Stefnsson. I personally think that not saving people with these mutations is a crime. This is an enormous risk to a large number of people.
The Icelandic Ministry of Welfare said a special committee had been formed to regulate such incidental findings and would propose regulations by the end of the year.
Kri Stefnsson
The technique used by DeCode to predict peoples genes offers clues to the future of so-called precision medicine in other countries, including the U.S., where this year President Barack Obama called for researchers to assemble a giant database of one million people (see U.S to Develop DNA Study of One Million People). A large enough U.S. database could also be used to infer genes of people whether or not they had joined it, says Stefnsson, and could raise similar questions about whether and how to report health hazards to the public.
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Iceland's Giant Genome Project Points to Future of Medicine
Posted: at 10:47 am
Photo: Chris Lund The blood of a thousand Icelanders.
When the first Viking explorers began settling Iceland, none could have imagined that theirdescendants would pioneer thefuture of modern medicine by surveying the human genome. Fast forward 1000 years to today, whenanIcelandic company has revealedits success insequencing the largest-ever set of human genomes from a single population. The new wealth of genetic data has already begunchanging our understanding of human evolutionary history. It also sets the stage for a new era of preventive medicinebased on individual genetic risks fordiseases such as cancer and Alzheimers disease.
Themilestone in genome sequencing comesfromdeCODE Genetics, a biopharmaceutical company inReykjavk, Iceland. Theirwork, published as four papers in the 25 March 2015 issue of the journalNature Genetics,has yielded new insights aboutthecommon human ancestor for the male Y chromosomenarrowed tosomewhere between 174,000 and 321,000 years agobased on their latest calculation of human mutation rates. Another part of their work discovered thatabout 7.7 percent of the modern-day population has rare knockout genesgenes that have beendisabled by mutations. Early research has also revealed a mutation in theABCA7gene,whichdoubles the risk of Alzheimers disease in Iceland and other populations dominated by European ancestry.
These are just a handful of observations that have come out of the ability to look at the sequence of the genome of an entire nation,saidKari Stefansson, founder of deCODE Genetics, during a press briefing onMonday, 23 March.What is more, we are now sitting in Iceland with the possibility of taking advantage of these insights when it comes to the Icelandic healthcare system.
The company sequenced thewhole genomes of 2636 Icelanders and used those genomes as the basis for calculatingthe genetic variances for the entire Icelandic population.Iceland represents a unique laboratory for genetics researchers because much of the modern population traces its lineage to a relatively small number of founders; a fact that makes it easier to trace genealogies and pedigrees.
Myles Axton, chief editor ofNature Genetics, introduced the Monday press briefingbydescribing how the genetic sequencing strategy in Iceland could also work for other countries:
This strategy of sequencing the DNA of about 1 in 100 of the population, a total of 2,636 Icelanders, and then using shared sets of common genetic variance to predict the full spectrum of genetic variance carried by the whole population, is a great model for the future of human genetics. This technique can be applied to any population and is all the more accurate when there are pedigrees available for much of the population.
Genome sequencing has alloweddeCODE Genetics to begin data-mining information about how certain genes function and their relationship to a broad array of diseases. Past findings from such research included additional insights about gene variants associated with Alzheimers disease and schizophrenia.
The growing database on knockout genes may prove particularly helpful when matched against the phenotypes of individualsthe physical traits or characteristics that can be observed. Perhaps unsurprisingly, the researchers found that knockouts are least common among genes expressed in the brain, given that organs importance.
Basically what we hope to get out of phenotyping the carriers of these knockouts is to figure out which biochemical pathways are necessary for which physiological functions, Stefansson explained.Then the question is whetherthere is redundancy in some of these physiological functions;are there alternative biochemical pathways that can compensate for the loss of one?
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A mile deep, ocean fish facing health impacts from human pollution
Posted: at 10:47 am
IMAGE:The testicle from a male trout which contains a developing egg is an example of "intersex " conditions that can result from pollution. view more
CORVALLIS, Ore. - Deep-water marine fish living on the continental slopes at depths from 2,000 feet to one mile have liver pathologies, tumors and other health problems that may be linked to human-caused pollution, one of the first studies of its type has found.
The research, conducted in the Bay of Biscay west of France, also discovered the first case of a deep water fish species with an "intersex" condition, a blend of male and female sex organs. The sampling was done in an area with no apparent point-source pollution, and appears to reflect general ocean conditions.
The findings have been published in Marine Environmental Research, by scientists from Oregon State University; the Centre for Environment, Fisheries and Aquaculture Science in the United Kingdom; and other agencies. It was supported by the European Union.
The research is of particular interest, OSU researchers said, when contrasted to other studies done several years ago in national parks of the American West, which also found significant pollution and fish health impacts, including male fish that had been "feminized" and developed eggs.
"In areas ranging from pristine, high mountain lakes of the United States to ocean waters off the coasts of France and Spain, we've now found evidence of possible human-caused pollution that's bad enough to have pathological impacts on fish," said Michael Kent, a professor of microbiology in the OSU College of Science, co-author on both these research projects and an international expert on fish disease.
"Deep in the ocean one might have thought that the level of contamination and its biological impact would be less," Kent said. "That may not be the case. The pathological changes we're seeing are clearly the type associated with exposure to toxins and carcinogens."
However, linking these changes in the deep water fish to pollution is preliminary at this time, the researchers said, because these same changes may also be caused by naturally-occurring compounds. Follow up chemical analyses would provide more conclusive links with the pathological changes and man's activity, they said.
Few, if any health surveys of this type have been done on the fish living on the continental slopes, the researchers said. Most past studies have looked only at their parasite fauna, not more internal biological problems such as liver damage. The issues are important, however, since there's growing interest in these areas as a fisheries resource, as other fisheries on the shallower continental shelf become depleted.
As the sea deepens along these continental slopes, it's been known that it can act as a sink for heavy metal contaminants such as mercury, cadmium and lead, and organic contaminants such as PCBs and pesticides. Some of the "intersex" fish that have been discovered elsewhere are also believed to have mutated sex organs caused by "endocrine disrupting chemicals" that can mimic estrogens.
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