Category Archives: Transhuman News

The Deeper Genome
John Parrington, author of The Deeper Genome, looks at the latest research about human DNA and why it is far more complex and more dynamically changing -- than we initially believed. http://ukc...

By: Oxford Academic (Oxford University Press)

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The Deeper Genome - Video

Thyroid Cancer: Biomarkers and Lessons from The Cancer Genome Atlas.Dr. Giordano. ThyCa Conference
241 Biomarkers in Thyroid Cancer: Lessons From The Cancer Genome Atlas (TCGA). 241 Thomas J. Giordano, M.D., Ph.D., Pathologist Biomarkers in Thyroid Cancer: Lessons From The Cancer ...

By: ThyCa: Thyroid Cancer Survivors #39; Association, Inc.

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Thyroid Cancer: Biomarkers and Lessons from The Cancer Genome Atlas.Dr. Giordano. ThyCa Conference - Video

251pp osu! Daidai Genome [Insane] NC
player https://osu.ppy.sh/u/3021716.

By: Res wery

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251pp osu! Daidai Genome [Insane] NC - Video

STI Genome Subaru Legacy B4 2007 BL9 2.5i
STI Genome Subaru Legacy B4 2007 BL9 2.5i Subaru Legacy B4 BLE 3.0 . ...

By: Genome

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STI Genome Subaru Legacy B4 2007 BL9 2.5i - Video

Breaking the Human Genome Code - Opening Pandora #39;s Box
Recent technology advances have resulted in the ability to sequence anyone #39;s genome cheaply and quickly, but we are only just beginning the journey to discover the true meaning of our individual...

By: The University of Sheffield

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Breaking the Human Genome Code - Opening Pandora's Box - Video

Citing the need to keep up with a rapidly changing field of science, Canadas principal entity for supporting research in genomics is changing its approach.

On Tuesday, Genome Canada is expected to announce it will spend $15.5-million over the next two years to jump-start the creation of what it calls an innovation network by doling out funds to 10 research centres across the country. Matching funds from other public and private sources will bring the initial investment in the network to $31-million. In addition, the centres will compete with one another to divide a $15-million pot earmarked for technology development.

The funding replaces an earlier five-centre model and puts more emphasis on collaboration between centres to avoid building up silos that cannot talk to each other, said Genome Canada president Pierre Meulien.

The expanded network represents a pivot for the non-profit organization, which channels federal money toward the branch of science that deals with the decoding and analysis of DNA sequences.

When Genome Canada was established in February, 2000, the price tag for sequencing a single human genome was about $100-million. Since then, a revolution in sequencing technology has pushed the price down to just more than $1,000 per genome and the field is increasingly concerned with comparing genetic differences among populations (of humans and many other organisms).

To reflect the change, Dr. Meulien said that the new network will include substantial investments in Canadas capacity to do bioinformatics, which marries computing power with the reams of data now available as genetic sequences accumulate. Analysis of such data has already yielded important breakthroughs in identifying the causes of genetically inherited diseases and in spotting genetically based susceptibilities to more complex maladies such as cancer and diabetes.

Data generation is getting easier, but in the end you have to interpret and analyze all of that data, said Guillaume Borque, co-director of the Canadian Centre for Computational Genomics, a collaboration between McGill Univeristy and the University of Toronto and one of the new centres in the expanded network.

Other new centres that will be included for the first time under the Genome Canada funding umbrella demonstrate a broader trend in the field to link genes identified through sequencing to their biological functions and health implications. For example, the Toronto Centre of Phenogenomics, another of the nodes, specializes in creating strains of mice with specific genetic mutations. that can be used in the development of new approaches for disease.

Its the whole picture thats going to give rise to new treatments and diagnostics, said Dr. Meulien.

The new network amounts to a retooling of the countrys genomics infrastructure, he added, marking a shift from the era when Genome Canada was needed to ensure that Canadian scientists had access to an expensive but crucially important new technology for biomedical research. Now, the research that the organization funds has expanded beyond health, with applications in agriculture and environmental science, among other areas.

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Genome Canada to create innovation network of 10 research centres

14 hours ago by Anthony Wrigley And Ainsley Newson, The Conversation In the future, our DNA could be different by design. Credit: http://www.shutterstock.com

The ability to precisely and accurately change almost any part of any genome, even in complex species such as humans, may soon become a reality through genome editing. But with great power comes great responsibility and few subjects elicit such heated debates about moral rights and wrongs.

Although genetic engineering techniques have been around for some time, genome editing can achieve this with lower error rates, more simply and cheaply than ever although the technology is certainly not yet perfect.

Genome editing offers a greater degree of control and precision in how specific DNA sequences are changed. It could be used in basic science, for human health, or improvements to crops. There are a variety of techniques but clustered regularly inter-spaced short palindromic repeats, or CRISPR, is perhaps the foremost.

CRISPR has prompted recent calls for a genome editing moratorium from a group of concerned US academics. Because it is the easiest technique to set up and so could be quickly and widely adopted, the fear is that it may be put into use far too soon outstripping our understanding of its safety implications and preventing any opportunity to think about how such powerful tools should be controlled.

The ethics of genetics, revisited

Ethical concerns over genetic modification are not new, particularly when it comes to humans. While we don't think genome editing gives rise to any completely new ethical concerns, there is more to gene editing than just genetic modification.

First, there is no clear consensus as to whether genome editing is just an incremental step forward, or whether it represents a disruptive technology capable of overthrowing the current orthodoxy. If this is the case and it's a very real prospect then we will need to carefully consider genome editing's ethical implications, including whether current regulation is adequate.

Second, there are significant ethical concerns over the potential scope and scale of genome editing modifications. As more researchers use CRISPR to achieve more genome changes, the implications shift. Our consideration of a technology that is rarely used and then only in specific cases will differ from one that is widely used and put to all sorts of uses.

Should we reach this tipping point, we will have to revisit the conclusions of the first few decades of the genetic modification debate. Currently modifying plants, some animals, and non-inheritable cells in humans is allowed under strict controls. But modifications that alter the human germ-line are not allowed, with the exception of the recent decision in the UK to allow mitochondrial replacement.

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Genome editing poses ethical problems that we cannot ignore