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genome pronounciation pagbigkas aussprache pronncia prononciation uitspraak – Video
Posted: April 14, 2015 at 9:44 pm
genome pronounciation pagbigkas aussprache pronncia prononciation uitspraak
YouTube: http://bit.ly/1HSTKia The video does not have sound. The video shows you how to move your tongue and lips to pronounce the word. The tongue is shown on the left from the side view....
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High fidelity: Researcher finds keys to genome
Posted: at 9:44 pm
Maintaining the stability and the correct sequence of our genetic information is vital to the accurate transmission of our genetic code. However, in the course of replicating, our DNA frequently runs into roadblocks, arising from both internal and external sources, that threaten the fidelity of our genetic information. The accurate processing of these roadblocks is paramount to genome integrity. Defects in this process can lead to cancer, genetic problems and premature aging.
In a research paper published in the Journal of Cell Biology, Alessandro Vindigni, Ph.D., professor in the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University, shares a discovery that explains how cells use a process called replication fork reversal in order to deal with these roadblocks and transmit accurate genetic data.
Lesions in DNA can occur as often as 100,000 times per cell per day. They can be the result of normal metabolic activities, like free radicals, as well as exposure to environmental factors such as UV radiation, X-rays and chemical compounds.
Improper repair of DNA lesions can lead to mutations, abnormal chromosome structures, or loss of genetic information that in turn can cause premature aging, cancer, and genetic abnormalities.
Depending on the degree of genome instability, these alterations will determine whether a cell survives, goes into a growth-arrest state, or dies.
If the cell's replication machinery collides with the lesion, a strand break can occur.
"If these strands are not repaired properly, the cell may simply die," Vindigni said. "Or, growth may be permanently interrupted.
"Or, a serious lesion may be tolerated and the cell will continue to replicate. This may or may not be a good decision, as this can lead to cancer. It is the degree of genomic instability caused by the lesion that will determine whether the cell will survive."
While these scenarios pose serious threats, our cells have evolved elegant mechanisms to cope, Vindigni says.
DNA replicates by unzipping its two interwoven strands and making copies of each. As the DNA strands separate and copy, they form a "replication fork." Sometimes, these forks run into obstacles -- like the lesions described above -- that block their progress. When they do, cells often perform a maneuver called fork reversal.
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High fidelity: Researcher finds keys to genome
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High fidelity: SLU researcher finds keys to genome integrity
Posted: at 9:44 pm
IMAGE:Saint Louis University research team: Shivasankari Gomathinayagam, Alessandro Vindigni, Monica Carron, Megan Fabry, Denisse Carvajal, Galyna Yakymechko, Matteo Berti, Saravanabhavan Thangavel. view more
Credit: Saint Louis University
ST. LOUIS - Maintaining the stability and the correct sequence of our genetic information is vital to the accurate transmission of our genetic code. However, in the course of replicating, our DNA frequently runs into roadblocks, arising from both internal and external sources, that threaten the fidelity of our genetic information. The accurate processing of these roadblocks is paramount to genome integrity. Defects in this process can lead to cancer, genetic problems and premature aging.
In a research paper published in the Journal of Cell Biology, Alessandro Vindigni, Ph.D., professor in the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University, shares a discovery that explains how cells use a process called replication fork reversal in order to deal with these roadblocks and transmit accurate genetic data.
Lesions in DNA can occur as often as 100,000 times per cell per day. They can be the result of normal metabolic activities, like free radicals, as well as exposure to environmental factors such as UV radiation, X-rays and chemical compounds.
Improper repair of DNA lesions can lead to mutations, abnormal chromosome structures, or loss of genetic information that in turn can cause premature aging, cancer, and genetic abnormalities.
Depending on the degree of genome instability, these alterations will determine whether a cell survives, goes into a growth-arrest state, or dies.
If the cell's replication machinery collides with the lesion, a strand break can occur.
"If these strands are not repaired properly, the cell may simply die," Vindigni said. "Or, growth may be permanently interrupted.
"Or, a serious lesion may be tolerated and the cell will continue to replicate. This may or may not be a good decision, as this can lead to cancer. It is the degree of genomic instability caused by the lesion that will determine whether the cell will survive."
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High fidelity: SLU researcher finds keys to genome integrity
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Northeast Delta HSA and Louisiana Department of Health and Hospitals (DHH) Provide Healthcare State of the Region at …
Posted: at 9:44 pm
Monroe, LA (PRWEB) April 14, 2015
Northeast Delta Human Services Authority (NE Delta HSA) hosted its annual Substance Abuse Prevention and Treatment Services Public Forum today with Louisiana DHH officials. NE Delta HSA Executive Director Dr. Monteic A. Sizer welcomed guests and led a dialogue that enabled healthcare providers and other attendees to voice some of the greatest concerns and issues our region faces.
Louisiana Department of Health and Hospitals Assistant Secretary/Medical Director, Dr. Rochelle Head-Dunham, MC, FAPA, updated guests in regard to the upcoming fiscal year 2016 transition to the Bayou Health Managed Care Organizations (MCO) model, which goes into effect on December 1, 2015. We will all have to do business much differently to expand services to our population, she said. Our goal is to not only meet our citizens needs, but also improve their health outcomes by decreasing morbidity and mortality and increase longevity.
Were working with DHH to effectively navigate this transitional period, making sure our clients are not lost, said Dr. Sizer. Were seeking to build a stronger network which is being delivered every step of the way with our three tenets: greater access to services, delivered by quality, competent providers with excellent customer service.
Additionally, we are seeking to establish new service agreements with all five Bayou Health Plan organizations in an effort to maximize service opportunities for our clients, said Dr. Sizer. But most importantly, we will strive to utilize innovation and collaboration to ensure that our citizens health will prosper across our region.
NE Delta HSA Director of Clinic Services, Martha Phillips and Regional Prevention Coordinator Jean Hartzog presented the State of the Region by explaining substance abuse, addiction and prevention services available to citizens.
Avius Carroll-Zimmerman, NE Delta HSA Research & Development, gave the attendees an update about NE Delta HSAs Primary and Behavioral Health Integration Model, which is centered around regional partnerships with primary care organizations and hospitals to provide integrated behavioral and primary healthcare services.
At the conclusion of the presentation, Forum attendees had the opportunity ask questions about how changes in statewide healthcare will affect the way they serve consumers.
NE Delta HSA administers its Substance Abuse Prevention and Treatment Block Grant (SABG) from the Substance Abuse and Mental Health Services Administration (SAMHSA), the federal agency that leads public health efforts to advance the behavioral health of the nation.
To see photos from the Public Forum on our Facebook page, click here.
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Will we ever see a 200-year-old human?
Posted: at 9:44 pm
Chuck Bednar for redOrbit.com @BednarChuck
From legends of the Fountain of Youth to classic comedy skits about people who have lived for more than two millennia, age has long captured the imagination of people all over the world who wonder just how far science may one day be able to stretch the limits of longevity.
Following last weeks death of 116-year-old Arkansas native Gertrude Weaver (who briefly was the worlds oldest living person), Discovery News posed the question, given new kinds of drugs and technology, can we push the limits of human lifespan beyond 130, to even 200 years?
Technology might keep us alive for even 1,000 years
According to the website, Aubrey de Grey, editor-in-chief of the academic journal Rejuvenation Research and Chief Science Officer of the SENS Research Foundation, claims that by finding a cure for a handful of diseases and developing new treatments for aging, we could one day wind up with humans who live for upwards of 1,000 years.
De Grey, who received his Ph.D. in Biology from the University of Cambridge and who is a fellow of the Gerontological Society of America and the American Aging Association, and his SENS colleagues explain on their website that they not only fund studies on aging, but also conduct experiments of their own at their California-based research center, fund researchers through educational grants, and host conferences to discuss medical issues.
SENS explains that its goal is to address the cellular and molecular damage to a persons body that is responsible for aging without altering the metabolism. Instead, the group said that it is seeking new therapies that target and repair this damage treatments that apply techniques from regenerative medicine to the damage of aging called rejuvenation biotechnologies.
Age-related research projects: are they worth it?
However, as Discovery News pointed out, SENS is not the only organization looking to find the scientific equivalent to the Fountain of Youth. Dr. Joon Yun, a board-certified radiologist and the managing partner and president of investment management firm Palo Alto Investors, LLC, has recently offered a $1 million dollar prize to scientists who can reverse the aging process.
Similarly, Google launched a research division known as Calico Labs last year to study ways to slow the aging process and to combat age-related diseases. In March, that company reached a four-year deal with the University of Californias QB3 biotech institute to conduct research into longevity and age-related diseases. The goal, Calico said in a statement, was to better understand the biology of aging and to develop new therapies for treating age-related diseases.
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Will we ever see a 200-year-old human?
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Curing Psoriasis Naturally Week 29, GUESS THE SONG, BLOOD RAIN IS COMING and MORE PENNY TIME – Video
Posted: at 9:44 pm
Curing Psoriasis Naturally Week 29, GUESS THE SONG, BLOOD RAIN IS COMING and MORE PENNY TIME
A fantastic week, skin is doing very well. The UK weather has been absolutely stunning this week and the sun has been very warm. This has helped a lot I think, I #39;ve even got a slight tan! ...
By: Jon Maddison
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Curing Psoriasis Naturally Week 29, GUESS THE SONG, BLOOD RAIN IS COMING and MORE PENNY TIME - Video
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Mystery of Rett timing explained in MeCP2 binding
Posted: at 9:43 pm
HOUSTON - (April 13, 2015) - For decades, scientists and physicians have puzzled over the fact that infants with the postnatal neurodevelopmental disorder Rett syndrome show symptoms of the disorder from one to two years after birth.
In a report in the Proceedings of the National Academy of Sciences, Dr. Huda Zoghbi and her colleagues from Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, unravel the mystery by looking at when and how the causal gene involved (methyl-CpG binding protein 2 or MECP2) binds to methylated cytosine over the course of brain development.
Using mice in which the MeCP2 protein is tagged with a fluorescent green protein, they determined genome-wide MeCP2 binding profiles in the adult animal brain. In addition to the expected finding of MeCP2 binding to methylated cytosine with guanine (CG) with high affinity, they also found that MeCP2 binds to cytosine when it is followed by either adenine, cytosine or thymine instead of guanine (non-CG methylation or "mCH").
"This pattern is unique to the maturing and adult nervous system," said Zoghbi. She noted that genes that accumulate non-CG methylation after birth are preferentially dysregulated in mouse of models of diseases associated with the lack of, or elevations, of the MeCP2 protein.
"This suggests that MeCP2 binds to newly established methylated cytosine followed by any base other than a guanine as neurons mature to enact its function of regulating gene expression," said Zoghbi
The study provides insight into the molecular mechanism that governs MeCP2 and also gives a rationale for why the symptoms occur at least a year after birth.
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Others who took part in this work include Drs. Lin Chen, Kaifu Chen, Laura A. Lavery, Steven Andrew Baker, Chad Shaw and Wei Li, all of Baylor College of Medicine. Zoghbi is director of the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and a Howard Hughes Medical Institute investigator.
Funding for this work came from the Genomic and RNA Profiling Core at Baylor College of Medicine and National Institutes of Health Grant P30HD024064 (Intellectual and Developmental Disabilities Research Center) to generate the datasets; National Institutes of Health Grant 5R01NS057819 (to H.Y.Z.); National Institutes of Health Grant HG007538 (to W.L.); Cancer Prevention Research Institute of Texas Grants RP110471 and RP150292 (to W.L.) and the Howard Hughes Medical Institute.
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
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Mystery of Rett timing explained in MeCP2 binding
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ReviewTechUSA Pro Censorship Exposed As Hypocrite – Video
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ReviewTechUSA Pro Censorship Exposed As Hypocrite
Tags: ReviewTechUSA Hypocrite Pro-Censorship Censor E-Begged Marriage Liar Flip flop Lies Eating Disorder Food Addiction eBay Fraud Selling Broken Hardware Exposed Rich richard masucci ...
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ReviewTechUSA Pro Censorship Exposed As Hypocrite - Video
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5 Censorship Trivia – VGFacts Five Trivia Feat. Caddicarus – Video
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5 Censorship Trivia - VGFacts Five Trivia Feat. Caddicarus
Subscribe for more gaming trivia! http://bit.ly/DYKG_Subscribe http://vgfacts.com - http://didyouknowgaming.com Check out VGFacts.com! You can also follow us at the links below. https://www.faceb...
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CENSORSHIP: X -FILES AND SUPER-SOLDIERS OF DR. WILHELM REICH – Video
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CENSORSHIP: X -FILES AND SUPER-SOLDIERS OF DR. WILHELM REICH
Doctor of Medicine "Reich #39;s theories held that deficits or constrictions in bodily orgone were at the root of many diseasesincluding cancermuch as deficits or constrictions in the libido...
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CENSORSHIP: X -FILES AND SUPER-SOLDIERS OF DR. WILHELM REICH - Video
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