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Category Archives: Transhuman News

Human Longevity, Inc. and Discovery Ltd to Offer… — SAN …

Posted: October 26, 2015 at 9:42 am

SAN DIEGO and SANDTON, South Africa, Sept. 22, 2015 /PRNewswire/ -- Human Longevity, Inc. (HLI), the genomics-based, technology-driven company, and Discovery Ltd, a pioneering insurer dedicated to making people healthier, announced today that the two companies have entered into a multi-year agreement to offer whole exome, whole genome and cancer genome sequencing to Discovery's clients in South Africa and the United Kingdom.

Through this agreement, HLI will offer a full exome sequencing and analysis product tailored to Discovery's clients for just $250 USD.

Discovery clients will access these new services through the company's Vitality Program, a behavioral wellness solution that helps people get healthier by giving them the tools, knowledge, access and incentives to improve their health. Discovery partners with major global insurers across four continents with its Vitality program, which encourages behavior change, enables behavior-linked insurance pricing and offers shared value to insurers, clients and society.

"Discovery is excited to be partnering with HLI in bringing affordable genome sequencing to large numbers of its clients in South Africa and the United Kingdom. We believe that this is a pioneering approach in global health insurance, and will enable us to provide our clients with the world's most advanced, current knowledge on their genetically determined disease risks, as well as on personalized health, wellness and medical treatment strategies. In addition, the de-identified genomic data will be used for extensive ongoing research with numerous collaborators around the world, and we are excited that together with our clients, we will be able to make a material contribution to global research efforts aimed at improving the health of populations and reducing the growing burden of diseases of lifestyle," said Dr. Jonathan Broomberg, MD, Ph.D, CEO of Discovery Health.

All Discovery clients who choose to participate in this unprecedented health screening will be provided a comprehensive report of their genome findings which includes disease risk and potential wellness strategies. HLI will provide this information to Discovery who will deliver these reports to clients through their network of physicians and genetic counselors to aid in the understanding and interpretation of each individual's genome report. Clients will also benefit from regular updates to their reports, as new scientific discoveries emerge, and will be able to access these via specially designed web and app interfaces. The highest standards of data security will be implemented by both HLI and Discovery, ensuring that client data is fully protected.

"We are eager to begin working with Discovery and its Vitality program to bring this unique insurance offering to their clients. Discovery is one of the most forward-looking companies in the industry in motivating their clients to live healthier, better and hopefully longer lives. We can't imagine a better partner for our products and technology. We believe that genomic understanding of individuals is one of the best ways to positively impact human health and health outcomes. Together Discovery and HLI are paving the way for a new healthcare future," said J. Craig Venter, Ph.D., Co-founder and CEO, HLI.

HLI is developing and applying large scale computing and machine learning to make novel discoveries to revolutionize the practice of medicine. Through the agreement HLI will also receive de-identified data from participating Discovery clients. The combined genomic and phenotypic data becomes part of the HLI database and will support HLI in further expanding the world's largest and most comprehensive collection of whole genome, phenotype and clinical data.

As part of this agreement Discovery and HLI will also work to develop and open HLI Health Nucleus centers in South Africa and the UK. The HLI Health Nucleus is a unique free-standing health center where clients receive a complete biological and health assessment of themselves through genome, microbiome, metabolome sequencing, along with comprehensive MRI body scans and other more traditional clinical testing. The first Health Nucleus is opening October 2015 at HLI's San Diego, California headquarters.

The partnership between Discovery and HLI will be available in the UK to clients of VitalityHealth. Previously a joint venture with Prudential plc, PruHealth became a wholly-owned business in the Discovery Group and was branded as VitalityHealth. VitalityHealth's unique model offers a holistic healthcare solution that integrates wellness and prevention programs with traditional health coverage to over 550,000 customers in the UK.

About Human Longevity, Inc. Human Longevity Inc. (HLI) is the genomics-based, technology-driven company creating the world's largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries to revolutionize the practice of medicine.HLI will be licensing access to its database, and developing new diagnostics and therapeutics as part of their product offerings. For more information please visit, http://www.humanlongevity.com.

About Discovery Ltd Discovery Limited is a South African-founded financial services organization that operates in the healthcare, life assurance, short-term insurance, savings and investment products and wellness markets. Founded in 1992, Discovery was guided by a clear core purpose to make people healthier and to enhance and protect their lives. Underpinning this core purpose is the belief that through innovation, Discovery can be a powerful market disruptor.

The company, with headquarters in Johannesburg, South Africa, currently serves over 4.4 million clients across South Africa, the United Kingdom, the United States, China, Singapore and Australia. Discovery recently announced an intent to partner with Generali, a leading insurer in Europe, and has partnered with John Hancock in the US. These new partnerships will bring Discovery's shared-value business model to the insurance and protection industries in Europe and the US. In its partnerships and joint ventures with leading insurers globally, Discovery acts as an intellectual property provider, and uses the flexibility of the Vitality model to bring a comprehensive wellness platform that is non-discriminatory and intuitive to clients around the world, using a global network of screening, physical activity, nutrition and incentive partners.

Vitality, Discovery's wellness program, is the world's largest scientific, incentive-based wellness solution for individuals and corporates. The global Vitality membership base now exceeds three million lives in five markets. Discovery is an authorized financial services provider and trades under the code "DSY" on the Johannesburg Securities Exchange.Follow us on Twitter @Discovery_SA

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Psoriasis – American Academy of Dermatology

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What is psoriasis? Watch this video as dermatologist David M. Pariser, MD, FAAD, explains why we get psoriasis and the benefits of treatment.

To watch the entire video, which includes inspiring tips from Jerry Mathers, who lives with psoriasis and is best known as the Beaver in the TV show "Leave it to Beaver," visit thePsoriasis video library.

Psoriasis (sore-EYE-ah-sis) is a chronic (long-lasting) disease. It develops when a persons immune system sends faulty signals that tell skin cells to grow too quickly. New skin cells form in days rather than weeks.

The body does not shed these excess skin cells. The skin cells pile up on the surface of the skin, causing patches of psoriasis to appear. Psoriasis may look contagious, but it's not.

You cannot get psoriasis from touching someone who has it. To get psoriasis, a person must inherit the genes that cause it.

If you have psoriasis, you will have one or more of these types:

Some people get more than one type. Sometimes a person gets one type of psoriasis, and then the type of psoriasis changes.

Image used with permission of the American Academy of Dermatology National Library of Dermatologic Teaching Slides.

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Gene Therapy – Genetics Home Reference

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Please choose from the following list of questions for information about gene therapy, an experimental technique that uses genetic material to treat or prevent disease.

On this page:

Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patients cells instead of using drugs or surgery. Researchers are testing several approaches to gene therapy, including:

Replacing a mutated gene that causes disease with a healthy copy of the gene.

Inactivating, or knocking out, a mutated gene that is functioning improperly.

Introducing a new gene into the body to help fight a disease.

Although gene therapy is a promising treatment option for a number of diseases (including inherited disorders, some types of cancer, and certain viral infections), the technique remains risky and is still under study to make sure that it will be safe and effective. Gene therapy is currently only being tested for the treatment of diseases that have no other cures.

MedlinePlus from the National Library of Medicine offers a list of links to information about genes and gene therapy.

Educational resources related to gene therapy are available from GeneEd.

The Genetic Science Learning Center at the University of Utah provides an interactive introduction to gene therapy and a discussion of several diseases for which gene therapy has been successful.

The Centre for Genetics Education provides an introduction to gene therapy, including a discussion of ethical and safety considerations.

KidsHealth from Nemours offers a fact sheet called Gene Therapy and Children.

Additional information about gene therapy is available from the National Genetics and Genomics Education Centre of the National Health Service (UK)

Gene therapy is designed to introduce genetic material into cells to compensate for abnormal genes or to make a beneficial protein. If a mutated gene causes a necessary protein to be faulty or missing, gene therapy may be able to introduce a normal copy of the gene to restore the function of the protein.

A gene that is inserted directly into a cell usually does not function. Instead, a carrier called a vector is genetically engineered to deliver the gene. Certain viruses are often used as vectors because they can deliver the new gene by infecting the cell. The viruses are modified so they cant cause disease when used in people. Some types of virus, such as retroviruses, integrate their genetic material (including the new gene) into a chromosome in the human cell. Other viruses, such as adenoviruses, introduce their DNA into the nucleus of the cell, but the DNA is not integrated into a chromosome.

The vector can be injected or given intravenously (by IV) directly into a specific tissue in the body, where it is taken up by individual cells. Alternately, a sample of the patients cells can be removed and exposed to the vector in a laboratory setting. The cells containing the vector are then returned to the patient. If the treatment is successful, the new gene delivered by the vector will make a functioning protein.

Researchers must overcome many technical challenges before gene therapy will be a practical approach to treating disease. For example, scientists must find better ways to deliver genes and target them to particular cells. They must also ensure that new genes are precisely controlled by the body.

A new gene is injected into an adenovirus vector, which is used to introduce the modified DNA into a human cell. If the treatment is successful, the new gene will make a functional protein.

The Genetic Science Learning Center at the University of Utah provides information about various technical aspects of gene therapy in Gene Delivery: Tools of the Trade. They also discuss other approaches to gene therapy and offer a related learning activity called Space Doctor.

The Better Health Channel from the State Government of Victoria (Australia) provides a brief introduction to gene therapy, including the gene therapy process and delivery techniques.

Penn Medicines Oncolink describes how gene therapy works and how it is administered to patients.

Gene therapy is under study to determine whether it could be used to treat disease. Current research is evaluating the safety of gene therapy; future studies will test whether it is an effective treatment option. Several studies have already shown that this approach can have very serious health risks, such as toxicity, inflammation, and cancer. Because the techniques are relatively new, some of the risks may be unpredictable; however, medical researchers, institutions, and regulatory agencies are working to ensure that gene therapy research is as safe as possible.

Comprehensive federal laws, regulations, and guidelines help protect people who participate in research studies (called clinical trials). The U.S. Food and Drug Administration (FDA) regulates all gene therapy products in the United States and oversees research in this area. Researchers who wish to test an approach in a clinical trial must first obtain permission from the FDA. The FDA has the authority to reject or suspend clinical trials that are suspected of being unsafe for participants.

The National Institutes of Health (NIH) also plays an important role in ensuring the safety of gene therapy research. NIH provides guidelines for investigators and institutions (such as universities and hospitals) to follow when conducting clinical trials with gene therapy. These guidelines state that clinical trials at institutions receiving NIH funding for this type of research must be registered with the NIH Office of Biotechnology Activities. The protocol, or plan, for each clinical trial is then reviewed by the NIH Recombinant DNA Advisory Committee (RAC) to determine whether it raises medical, ethical, or safety issues that warrant further discussion at one of the RACs public meetings.

An Institutional Review Board (IRB) and an Institutional Biosafety Committee (IBC) must approve each gene therapy clinical trial before it can be carried out. An IRB is a committee of scientific and medical advisors and consumers that reviews all research within an institution. An IBC is a group that reviews and approves an institutions potentially hazardous research studies. Multiple levels of evaluation and oversight ensure that safety concerns are a top priority in the planning and carrying out of gene therapy research.

Information about the development of new gene therapies and the FDAs role in overseeing the safety of gene therapy research can be found in the fact sheet Human Gene Therapies: Novel Product Development Q&A.

The Genetic Science Learning Center at the University of Utah explains challenges related to gene therapy.

The NIHs Office of Biotechnology Activities provides NIH guidelines for biosafety.

Because gene therapy involves making changes to the bodys set of basic instructions, it raises many unique ethical concerns. The ethical questions surrounding gene therapy include:

How can good and bad uses of gene therapy be distinguished?

Who decides which traits are normal and which constitute a disability or disorder?

Will the high costs of gene therapy make it available only to the wealthy?

Could the widespread use of gene therapy make society less accepting of people who are different?

Should people be allowed to use gene therapy to enhance basic human traits such as height, intelligence, or athletic ability?

Current gene therapy research has focused on treating individuals by targeting the therapy to body cells such as bone marrow or blood cells. This type of gene therapy cannot be passed on to a persons children. Gene therapy could be targeted to egg and sperm cells (germ cells), however, which would allow the inserted gene to be passed on to future generations. This approach is known as germline gene therapy.

The idea of germline gene therapy is controversial. While it could spare future generations in a family from having a particular genetic disorder, it might affect the development of a fetus in unexpected ways or have long-term side effects that are not yet known. Because people who would be affected by germline gene therapy are not yet born, they cant choose whether to have the treatment. Because of these ethical concerns, the U.S. Government does not allow federal funds to be used for research on germline gene therapy in people.

The National Human Genome Research Institute discusses scientific issues and ethical concerns surrounding germline gene therapy.

A discussion of the ethics of gene therapy and genetic engineering is available from the University of Missouri Center for Health Ethics.

Gene therapy is currently available only in a research setting. The U.S. Food and Drug Administration (FDA) has not yet approved any gene therapy products for sale in the United States.

Hundreds of research studies (clinical trials) are under way to test gene therapy as a treatment for genetic conditions, cancer, and HIV/AIDS. If you are interested in participating in a clinical trial, talk with your doctor or a genetics professional about how to participate.

You can also search for clinical trials online. ClinicalTrials.gov, a service of the National Institutes of Health, provides easy access to information on clinical trials. You can search for specific trials or browse by condition or trial sponsor. You may wish to refer to a list of gene therapy trials that are accepting (or will accept) participants.

Next: The Human Genome Project

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Definitions of Censorship – PBS

Posted: at 9:42 am

The term "censorship" comes from The Latin, censere "to give as one's opinion, to assess." The Roman censors were magistrates who took the census count and served as assessors and inspectors of morals and conduct.

In contrast to that straightforward definition from Roman times, contemporary usage offers no agreed-upon definition of the term or when to use it. Indeed, even whether the word itself applies to a given controversy in the arts is often vigorously contested.

Here are excerpts of definitions of "censorship" from U.S. organizations and publications with varying views. They are not intended as any composite mega-definition of the term, only as indications of the variety of approaches to this concept.

Censorship: The use of the state and other legal or official means to restrict speech. --Culture Wars, Documents from the Recent Controversies in the Arts, edited by Richard Boltons

In general, censorship of books is a supervision of the press in order to prevent any abuse of it. In this sense, every lawful authority, whose duty it is to protect its subjects from the ravages of a pernicious press, has the right of exercising censorship of books. --The Catholic Encyclopedia (a publication of the Catholic Church)

What Is Censorship? Censorship is the suppression of ideas and information that certain persons -- individuals, groups or government officials -- find objectionable or dangerous. It is no more complicated than someone saying, "Don't let anyone read this book, or buy that magazine, or view that film, because I object to it!" Censors try to use the power of the state to impose their view of what is truthful and appropriate, or offensive and objectionable, on everyone else. Censors pressure public institutions, like libraries, to suppress and remove from public access information they judge inappropriate or dangerous, so that no one else has the chance to read or view the material and make up their own minds about it. The censor wants to prejudge materials for everyone.

For the ALA, technically censorship means the "The Removal of material from open access by government authority." The ALA also distinguishes various levels of incidents in respect to materials in a library which may or may not lead to censorship: Inquiry, Expression of Concern, Complaint, Attack, and Censorship. --The American Library Association

The word "censorship" means "prior restraint" of First Amendment rights by government. --Morality in Media (Morality in Media is "a national, not-for-profit, interfaith organization established in 1962 to combat obscenity and uphold decency standards in the media.")

Censorship 1. The denial of freedom of speech or freedom of the press. 2. The review of books, movies, etc., to prohibit publication and distribution, usually for reasons of morality or state security. --Oran's Dictionary of Law

Censorship: official restriction of any expression believed to threaten the political, social, or moral order. --Encyclopedia.Com

Censorship - the prevention of publication, transmission, or exhibition of material considered undesirable for the general public to possess or be exposed to. --Fast Times' Political Dictionary (Fast Times is "a nonpartisan publication on contemporary world affairs & media with no political, ideological, or religious affiliation of any kind.")

Censorship: the cyclical suppression, banning, expurgation, or editing by an individual, institution, group or government that enforce or influence its decision against members of the public -- of any written or pictorial materials which that individual, institution, group or government deems obscene and "utterly" without redeeming social value," as determined by "contemporary community standards." --Chuck Stone, Professor of Journalism and Mass Communication, University of North Carolina

Censorship is a word of many meanings. In its broadest sense it refers to suppression of information, ideas, or artistic expression by anyone, whether government officials, church authorities, private pressure groups, or speakers, writers, and artists themselves. It may take place at any point in time, whether before an utterance occurs, prior to its widespread circulation, or by punishment of communicators after dissemination of their messages, so as to deter others from like expression. In its narrower, more legalistic sense, censorship means only the prevention by official government action of the circulation of messages already produced. Thus writers who "censor" themselves before putting words on paper, for fear of failing to sell their work, are not engaging in censorship in this narrower sense, nor are those who boycott sponsors of disliked television shows. --Academic American Encyclopedia

Censorship: supervision and control of the information and ideas circulated within a society. In modern times, censorship refers to the examination of media including books, periodicals, plays, motion pictures, and television and radio programs for the purpose of altering or suppressing parts thought to be offensive. The offensive material may be considered immoral or obscene, heretical or blasphemous, seditious or treasonable, or injurious to the national security. --Encarta Encyclopedia

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Media Censorship – Censorship | Laws.com

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Media Censorship Defined Media Censorship is the act of altering, adjusting, editing, or banning of any or all media resulting from the presumption that its content is perceived to be objectionable, incendiary, illicit, or immoral by the applicable legislative authority or Government within a specific jurisdiction. The ideology, methodology, and measures or determination regarding media subject to Media Censorship exists in conjunction to the vast expanse of the varieties of media in existence; this can include but is not limited to books, publications, expressions, products, services, radio broadcasts, televised broadcast, Internet-based broadcasts, films, movies, pictures, images, videos, and speech: The Causes of Media Censorship The nature of the media in question, as well as any prospective measures of Media Censorship undertaken is in direct violation of applicable legislation existing within a specific location or jurisdiction; in the event that Media Censorship is considered to be unlawful or in violation of human or civil rights entitled to the respective citizenship, the Media Censorship in question may undergo judicial review. Media Censorship of Criminal Activity Online Crimes are defined as the participation or engagement in unlawful, illicit, and illegal behavior through the usage of the Internet; digital Media Censorship of activities and expressions considered to be criminal in nature are vast the following are examples of criminal activity subject to censorship within the media: Media involving the promotion or undertaking of criminal activity, threat, malice, or the promotion of illegal and damaging ideas with the intent to cause harm Media involving subject matter and content presumed to endanger the welfare of the general public, in addition to media assumed to compromise the safety and wellbeing of the public Media that is in direct violation of accepted and applicable legislation with regard to a particular jurisdiction or location Media Censorship of Sexual Expression Illegal in Nature Media including pornographic images depicting minors, children, or individuals below the age of 18 is considered to be a very serious offense; this criminal activity is not only applicable to those parties responsible for the release of this nature of media, but also to those individuals in ownership of that material: The ownership, transmission, or receipt of pornography or media sexual in nature involving children The solicitation of minors or those below the age of consent to participate in sexual activity; this can range from physical sex crimes to virtual sex crimes Pornographic images depicting sexual acts involving animals, violence, injury, and simulated relationships illicit and unlawful in nature are also considered to be illegal and subject to Censorship in America Digital Media Censorship Internet Law, which may be classified under as a subgenre of Cyber Law or Computer Law, is considered by many to be one of the most recently-developed legal fields as a result of the ongoing advent of computer-based technology; furthermore, the notion of digital or virtual Media Censorship is considered to be overseen by legislation expressed within this legal field. The reliance of the media of modernity on Internet-based, online activity has promoted the development of a variety of measures addressing digital media censorship, including the ethical and moral use of the Internet for lawful and legal purposes. Comments

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Libertarianism: What Everyone Needs to Know

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Historically, Americans have seen libertarians as far outside the mainstream, but with the rise of the Tea Party movement, libertarian principles have risen to the forefront of Republican politics. But libertarianism is more than the philosophy of individual freedom and unfettered markets that Republicans have embraced. Indeed, as Jason Brennan points out, libertarianism is a quite different--and far richer--system of thought than most of us suspect.

In this timely new entry in Oxford's acclaimed series What Everyone Needs to Know, Brennan offers a nuanced portrait of libertarianism, proceeding through a series of questions to illuminate the essential elements of libertarianism and the problems the philosophy addresses, including such topics as the Value of Liberty, Human Nature and Ethics, Economic Liberty, Civil Rights, Social Justice and the Poor, Government and Democracy, and Contemporary Politics. Brennan asks the most fundamental and challenging questions: What do Libertarians think liberty is? Do libertarians think everyone should be selfish? Are libertarians just out to protect the interests of big business? What do libertarians think we should do about racial injustice? What would libertarians do about pollution? Are Tea Party activists true libertarians? As he sheds light on libertarian beliefs, Brennan overturns numerous misconceptions. Libertarianism is not about simple-minded paranoia about government, he writes. Rather, it celebrates the ideal of peaceful cooperation among free and equal people. Libertarians believe that the rich always capture political power; they want to minimize the power available to them in order to protect the weak. Brennan argues that libertarians are, in fact, animated by benevolence and a deep concern for the poor.

Clear, concise, and incisively written, this volume explains a vitally important philosophy in American history--and a potent force in contemporary politics.

What Everyone Needs to Know is a registered trademark of Oxford University Press.

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International Encyclopedia of Economic Sociology: Libertarianism

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This essay first appeared in the International Encyclopedia of Economic Sociology, edited by Jens Beckert and Milan Zafirovski (London and New York: Routledge, 2006, pp. 403-407). It was posted as a Notablog entry on 5 January 2006. Comments welcome (post here).

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"LIBERTARIANISM"

By Chris Matthew Sciabarra

Libertarianism is the political ideology ofvoluntarism, a commitment to voluntary action in a social context, where no individual or group of individuals can initiate the use of force against others. It is not a monolithic ideological paradigm; rather, it signifies a variety of approaches that celebrate therule of law and the free exchange of goods, services, and ideas a laissez-faire attitude towards what philosopher Robert Nozick (1974) once called capitalist acts between consenting adults.

Modern libertarians draw inspiration from writings attributed to the Chinese sage Lao Tzu, as well as the works of Aristotle, among the ancients; [seventeenth-,] eighteenth- and nineteenth-century classicalliberalism (e.g. John Locke, the Scottish Enlightenment, the American founders, Carl Menger, andHerbert Spencer); individualist anarchism (e.g. Benjamin Tucker and Lysander Spooner); Old Right opponents of Franklin D. Roosevelts New Deal (e.g. Albert Jay Nock, John T. Flynn, Isabel Paterson andH. L. Mencken); modern Austrian economics (e.g. Ludwig von Mises, F. A. Hayek and Murray Rothbard), as well as the economics of the Chicago school(Milton Friedman) and Virginia school (James Buchanan); and the Objectivist philosopherAyn Rand.

Classical liberalism is the most immediatepredecessor of contemporary libertarianism. Locke and the American founders had an impact on those libertarians, such as Rothbard and Rand, who stress individual rights, while the Scottish Enlightenment and Spencer had a major impact on thinkerssuch as Hayek, who stress the evolutionary wisdom of customs and traditions in contradistinctionto the constructivist rationalism of state planners.

Among evolutionists, Spencer in particularmade important contributions to what would become known as general systems theory; some consider him to be the founder of modern sociology. Indeed, he authored Principles of Sociology and TheStudy of Sociology, which was the textbook used for the first sociology course offered in the United States, at Yale University. A contemporary of Charles Darwin, he focused on social evolution the development of societies and organizational structuresfrom simple to compound forms. In such works as The Man Versus the State, he presented a conception of society as a spontaneous, integrated growth and not amanufacture, an organically evolving context for the development of heterogeneity and differentiation among the individuals who compose it. Just as Spencer emphasized organic social evolution, so too did he focus on the organic evolution of the state with its mutually reinforcing reliance onbureaucracy and militarism, and how it might be overcome.

The Austrian-born Carl Menger, a founder along with W. S. Jevons and Lon Walras of the marginalist revolution in economics, held a similar view of social life as a dynamic, spontaneous, evolving process. Influenced by Aristotle in his methodological individualism, Menger wasfervently opposed to the historical relativism of the German historicists of the Methodenstreit. Menger focused on the purposeful actions of individuals in generating unintended sociologicalconsequences a host of institutions, such as language, religion, law, the state, markets, competition and money.

In the twentieth century, the Nobel laureate Austrian economist F. A. Hayek carried on Mengers evolutionist discussion and praised it for providing outstanding guidelines for general sociology. For Hayek (1991), Menger was among the Darwinians before Darwin those evolutionists,such as the conservative Edmund Burke and the liberals of the Scottish Enlightenment, who stressed the evolution of institutions as the product of unintended consequences, rather than deliberate design. Hayek drew a direct parallel between hisown concept of spontaneous order and Adam Smiths notion of the invisible hand. Hayek argued that, over time, there is a competition among various emergent traditions, each of which embodies rivalrules of action and perception. Through a process of natural selection, those rules and institutions that are more durable than others will tend to flourish, resulting in a relative increase in population and wealth. Though he didnt argue for a theory of inevitable progress, as Spencer had, heclearly assumed that liberalism was the social system most conducive to such flourishing.

Like Karl Marx, Hayek criticized utopiansfor their desire to construct social institutions as if from an Archimedean standpoint, external to history and culture. But Hayek turned this analysis on Marx; he developed a full-fledged critique of socialism and central planning as utopian requiring an unattainable synoptic knowledge of all the articulated and tacit dimensions of social life. Hayek argued that market prices were indispensable to rational entrepreneurial calculation. He also focused on the sociological and psychological ramifications of the movement away from markets. He maintains in The Road to Serfdom (1944), for example, that there is a structural connection between social psychology and politics: to the extent that the stateimposes collectivist arrangements on individuals, it is destructive of individualchoice, morals and responsibility, and this destruction of individualism reinforces the spread of statism. And the more the state comes to dominate social life, says Hayek, the more state power will be the only power worth having which is why theworst get on top.

The Austrian economist Ludwig von Mises was similarly opposed to statism and collectivism, and presented, in [1922], an influential book entitled Socialism, which was an economic and sociological analysis of all forms of state intervention from fascism to communism. Mises used the tools of praxeology, the science of humanaction, to demonstrate the calculational problems that all non-market systems face, due to their elimination of private property, entrepreneurialism and the price system. More important, perhaps, is Misess development of a non-Marxist, libertarian theoryof class. Like Charles Dunoyer, Charles Comte, James Mill and other classical liberals, Mises argued that traders on the market share a mutuality of benefit that is destroyed by political intervention. For Mises, the long-term interests of marketparticipants are not in fundamental conflict. It is only with government action that such conflict becomes possible, Mises claims,because it is only government that can create a caste system based on the bestowal of special privileges.

Mises located the central caste conflictin the financial sector of the economy. In such books as The Theory of Money and Credit, he contends that government control over money and banking led to the cycle of boom and bust. A systematicincrease in the money supply creates differentialeffects over time, redistributing wealth to those social groups, especially banks and debtor industries, which are the first beneficiaries of the inflation.

Mises student, Murray Rothbard, developed this theory of caste conflict into a full-fledged libertarian class analysis. Rothbard views central banking as a cartelizing device that has created a powerful structure of class privilege in modern political economy. These privileges growexponentially as government restricts market competition and free entry, thereby creating monopoly through various coercive means (e.g. compulsory cartelization, price controls, output quotas, licensing, tariffs, immigration restrictions, labourlaws, conscription, patents, franchises, etc.).

Rothbards view of the relationship between big business and government in the rise of American statism draws additionally from the work of New Left historical revisionists, such as Gabriel Kolko andJames Weinstein. These historians held that big business was at the forefront of the movement towards government regulation of the market. That movement, according to Rothbard, had both a domestic and foreigncomponent, since it often entailed both domestic regulation and foreign imperialism to secure global markets. The creation of a welfare-warfare state leads necessarily to economic inefficiencies and deep distortions in the structure of production. Like Marx, Rothbard views these internal contradictions as potentially fatal to the economic system; unlike Marx, Rothbard blames these contradictions not on the free market, but on the growth of statism.

Drawing inspiration from Franz Oppenheimers and Albert Jay Nocks distinction between state power and social power, or state and market, and from John C. Calhouns class theory, as presented in Disquisition on Government, Rothbard sawsociety fragmenting, ultimately, into two opposing classes: taxpayers and tax-consumers. In his book Power and Market, Rothbard identifies bureaucrats, politicians and the net beneficiaries of government privilege as among the tax-consumers. Unlike his Austrian predecessors Hayek andMises, however, Rothbard argues that it is only with the elimination of the state that a fully just and productive society can emerge. His anarcho-capitalist ideal society would end the states monopoly on the coercive use of force, as well as taxation and conscription, and allow for the emergence of contractual agencies for the protectionof fully delineated private property rights (thereby resolving the problems of externalities and public goods) and the adjudication of disputes. His scenario had a major impact on Nozick, whose Anarchy,State, and Utopia was written in response to the Rothbardian anarchist challenge.

Ayn Rand, the Russian-born novelist and philosopher, author of best-selling novels TheFountainhead and Atlas Shrugged, was one of those who eschewed the libertarian label, partially because of its association with anarchism. An epistemological realist, ethical egoist and advocate of laissez-faire capitalism, Rand maintained that libertarians had focused too much attention on politics to the exclusion of the philosophical and cultural factors upon which it depended. But even though she saw politics as hierarchically dependent on these factors, she often stressed the reciprocal relationships among disparate elements, from politicsand pedagogy to sex, economics and psychology. She sought to transcend the dualities of mind and body, reason and emotion, theory and practice, fact and value, morality and prudence, and theconventional philosophic dichotomies of materialism and idealism, rationalism and empiricism, subjectivism and classical objectivism (which she called intrinsicism). Yet, despite her protestations, Rand can be placed in the libertarian tradition, given her adherence to its voluntarist political credo.

From the perspective of social theory, Rand proposed a multi-level sociological analysis of human relations under statism. Echoing the Austrian critique of state intervention in her analysis of politics and economics, Rand extended her critique toencompass epistemology, psychology, ethics and culture. She argued that statism both nourished and depended upon an irrational altruist and collectivist ethos that demanded the sacrifice of the individual to the group. It required and perpetuated a psychology of dependence and a groupmentality that was destructive of individual authenticity, integrity, honesty and responsibility. Rand also focused on the cultural preconditions and effects of statism since coercive social relations required fundamental alterations in the nature of language, education, pedagogy, aesthetics and ideology. Just as relations of power operatethrough ethical, psychological, cultural, political and economic dimensions, so too, for Rand, the struggle for freedom and individualism depends upon a certain constellation of moral, psychological, cultural and structural factors that support it. Randadvocated capitalism, the unknown ideal, as the only system capable of generating just social conditions, conducive to the individuals survival and flourishing.

See also: inflation; laissez faire; monopolyand oligopoly.

References and further reading

Calhoun, John C. ([1853]1953) A Disquisition onGovernment and Selections from the Discourse on the Constitution and Government of the United States, Indianapolis, IN: Bobbs-Merrill.

Hayek, F. A. (1944) The Road to Serfdom, Chicago:University of Chicago Press.

(1991) The Collected Works of F. A. Hayek,Volume 3: The Trend of Economic Thinking: Essays on Political Economists and Economic History, Chicago: University of Chicago Press.

Mises, Ludwig von ([1912]1981) The Theory ofMoney and Credit, Indianapolis, IN: Liberty Classics.

(1936) Socialism: An Economic and SociologicalAnalysis, London: Jonathan Cape.

Nozick, Robert (1974) Anarchy, State, and Utopia,New York: Basic Books.

Rand, Ayn (1967) Capitalism: The UnknownIdeal, New York: New American Library.

Rothbard, Murray ([1970]1977) Power and Market:Government and the Economy, Kansas City, MO: Sheed Andrews and McMeel.

(1978) For a New Liberty: The LibertarianManifesto, revised edition, New York: Collier Books.

Sciabarra, Chris Matthew (1995) Ayn Rand: TheRussian Radical, University Park, PA: PennsylvaniaState University Press.

(1995) Marx, Hayek, and Utopia, Albany,NY: State University of New York Press.

(2000) Total Freedom: Toward a DialecticalLibertarianism, University Park, PA: PennsylvaniaState University Press.

Spencer, Herbert (1873) The Study of Sociology,New York: D. Appleton.

(188298) The Principles of Sociology, threevolumes, London: Williams and Norgate.

([1940]1981) The Man Versus the State, withSix Essays on Government, Society, and Freedom, Indianapolis, IN: Liberty Classics.

CHRIS MATTHEW SCIABARRA

______ Note: [bracketed words] above are corrections to online version

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International Encyclopedia of Economic Sociology: Libertarianism

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Transhuman Singularity

Posted: at 9:40 am

A list of links to my science fiction short stories:

I am a Hummingbird After my body died the surgeons put me in a hummingbird. It took a while to get use to having my perspective darting around so quickly, but my mind had finally adapted to it.

Sneeze! A few days Mr. Anderson. Don't worry, it's a positive virus, I'm origin zero. Then you'll be one of us, welcome to the new global hivemind, we-I always choose well. It will be unlike anything you have ever experienced or imagined. Expect a mental call, anything will be possible, said Kay, a future echo ... Kay Noble replied, then collected the documents, velvet and all, and left the room without a further word.

Muffy the Time Traveling Chihuahua Muffy was a loyal pack dog on the locally collapsed time-day of his death, which varied in fractal quantum probability across a multitude of bifurcated futures or space-time universes.

Lunch 2032 Her IQ was probably skyrocket norm. It seems the gene engineers had given her both great brains and beauty. She wanted to be a Terraforming Research Scientist, but on Earth she would have to settle for other work. Her parents had lost most of their money in a wild Marsearth start-up investment, so she had to work her way through the university, no one would give a genmod scholarship. It was just plain and simple prejudice.

Virtuality Zane Pax hid behind a large bolder as the black alien warship flew overhead. NaHan had swarmed the cities of the world laying waste to human civilization. Humanity was on the endangered species list, on our way out for good.

The Alien Time-Traveler Historian Mathew answers, Variations of me exist in most all future branches. Thats really rare, and thats why Im allowed to speak to you. To help you understand. You see, those that are still basically human in the future have great compassion. They want to help reduce the suffering. Im here on their behalf to try and influence things.

The Galactic Culture Finally, in order to survive the approaching technological singularity and remove their aggressive and self-destructive evolved behaviors, pre-type 1 species sometimes begin an extensive program of self-initiated genetic re-engineering and intelligence amplification (usually proceeded by development of a global computing system -Internet). Sometimes this is successful, other times not.

Lunar CityOutward space exploration and expansion grew at a rapid pace, due to the privatization of all space exploration and its subsequent exploitation. Corporations headed by forward thinking executives now controlled access to space. Spaceports have sprouted up all over the world, giving average citizens access to affordable space travel. Now space stations, moon bases and asteroid factories, which provided most of the raw materials, have become independent space communities. Distant science outposts have been constructed on the outer planets and moons. The solar system has become the playground of humanity.

VR Prototype Jason Chen bent over in his subway seat to pick up a rarely seen plastic penny he spotted face-up on the train floor. A penny existed today only to make exact change for those who still stubbornly used physical money. He didnt understand why, but somehow its continued existence was comforting for some. Angling the lucky coin in his fingers to see the three-dimensional head of Abraham Lincoln, he noted the year on the coin was 2053, the year of his birth.

Dr. Xanoplatu Dr. Xanoplatu, an alien anthropologist, historian, and time traveler, materialized on stage wearing the body of his ancestors, a giant green Praying Mantis with large yellow eyes and small black pupils. He was speaking at a galactic cultural lecture, inside a de-localized spherical space station, somewhere and some when in a multi-versed space-time reality.

Virtuality Mind Marcus replies, Yes, you can assume Im crazy. But, Im just communicating to you through this mans body. For a short period of time, I can do this, without his knowing it. When I leave and his consciousness re-awakens, this memory will seem like a daydream to him.

Resurrection Birth Jason awoke to a static humming sound.It was so annoying, grating on his nerves more than a badly tuned alarm clock.He lifted his heavy eyelids to blinding light, and out of focus images.His vision slowly cleared and he realized he was inside a plastic coffin thing.

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Transhuman Singularity

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LIBERTARIANISM 101 – The Advocates for Self-Government

Posted: October 25, 2015 at 2:41 am

Your Way to Freedom, Abundance, Peace, and Justice

Libertarianism is, as the name implies, the belief in liberty. Libertarians strive for the best of all worlds a free, peaceful, abundant world where each individual has the maximum opportunity to pursue his or her dreams and to realize his full potential.

The core idea is simply stated, but profound and far-reaching in its implications. Libertarians believe that each person owns his or her own life and property, and has the right to make his own choices as to how he lives his life and uses his property as long as he simply respects the equal right of others to do the same.

Another way of saying this is that libertarians believe you should be free to do as you choose with your own life and property, as long as you dont harm the person or property of others.

Libertarianism is thus the combination of liberty (the freedom to live your life in any peaceful way you choose), responsibility (the prohibition against the use of force against others, except in defense) and tolerance (honoring and respecting the peaceful choices of others).

Libertarians believe that this combination of personal and economic liberty produces abundance, peace, harmony, creativity, order and safety. Indeed, that is one of the central lessons of world history. Virtually all the progress the human race has enjoyed during the past few centuries is due to the increasing acceptance of these principles. But we are still far from a truly libertarian world. Libertarians believe we would see far more progress, abundance and happiness if the ideas of liberty were fully accepted and allowed to work their miracles.

Our goal as libertarians is to bring liberty to the world, so that these humane and proven ideas can be put into action. This will make our world a far better place for all people.

If this interests you, please explore the material at this site. Evaluate these ideas. Kick their tires and take them for an intellectual test drive.

We hope you will join us in embracing this ideal and in taking a stand to personally help bring about a world of liberty, abundance and peace.

Theres more than just left or right.

Libertarians offer you a better choice than just left or right. The libertarian way gives you more choices, in politics, in business, your personal life. Libertarians advocate both personal and economic liberty. Todays liberals like personal liberty but want government to control your economic affairs. Conservatives reverse that, advocating more economic freedom but wanting to clamp down on your private life.

Libertarian positions on the issues are neither left nor right, nor a combination of the two. Libertarians believe that, on every issue, you have the right to decide for yourself whats best for you and to act on that belief as long as you respect the right of other people to do the same and deal with them peacefully and honestly.

In a sense, true conservatives tend to be libertarian on most economic issues, and true liberals tend to be libertarian on most social issues. Libertarians call for freedom across the board, on both economics and social issues, coupled with a foreign policy of peace as described by Thomas Jefferson:Peace, commerce, and honest friendship with all nations entangling alliances with none.

Libertarianism offers the opportunity to go beyond the stale left versus right debate and embrace liberty on every issue.

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LIBERTARIANISM 101 - The Advocates for Self-Government

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DNA Sequencing Costs – Genome.gov | National Human Genome …

Posted: October 24, 2015 at 12:42 pm

DNA Sequencing Costs Data from the NHGRI Genome Sequencing Program (GSP) Overview

For many years, the National Human Genome Research Institute (NHGRI) has tracked the costs associated with DNA sequencing performed at the sequencing centers funded by the Institute. This information has served as an important benchmark for assessing improvements in DNA sequencing technologies and for establishing the DNA sequencing capacity of the NHGRI Genome Sequencing Program (GSP). Here, NHGRI provides an analysis of these data, which gives one view of the remarkable improvements in DNA sequencing technologies and data-production pipelines in recent years.

The cost-accounting data presented here are summarized relative to two metrics: (1) "Cost per Megabase of DNA Sequence" - the cost of determining one megabase (Mb; a million bases) of DNA sequence of a specified quality [see below]; (2) "Cost per Genome" - the cost of sequencing a human-sized genome. For each, a graph is provided showing the data since 2001; in addition, the actual numbers reflected by the graphs are provided in a summary table. NHGRI welcomes people to download these graphs and use them in their presentations and teaching materials. NHGRI plans to update these data on a regular basis.

To illustrate the nature of the reductions in DNA sequencing costs, each graph also shows hypothetical data reflecting Moore's Law, which describes a long-term trend in the computer hardware industry that involves the doubling of 'compute power' every two years (See: Moore's Law [wikipedia.org]). Technology improvements that 'keep up' with Moore's Law are widely regarded to be doing exceedingly well, making it useful for comparison.

In both graphs, note: (1) the use a logarithmic scale on the Y axis; and (2) the sudden and profound out-pacing of Moore's Law beginning in January 2008. The latter represents the time when the sequencing centers transitioned from Sanger-based (dideoxy chain termination sequencing) to 'second generation' (or 'next-generation') DNA sequencing technologies. Additional details about these graphs are provided below.

These data, however, do not capture all of the costs associated with the NHGRI Large-Scale Genome Sequencing Program. The sequencing centers perform a number of additional activities whose costs are not appropriate to include when calculating costs for production-oriented DNA sequencing. In other words, NHGRI makes a distinction between 'production' activities and 'non-production' activities. Production activities are essential to the routine generation of large amounts of quality DNA sequence data that are made available in public databases; the costs associated with production DNA sequencing are summarized here and depicted on the two graphs. Additional information about the other activities performed by the sequencing centers is provided below.

The expenditures included in each category were established based on discussions between NHGRI staff and sequencing center personnel.

For the two graphs ("Cost per Megabase of DNA Sequence" and "Cost per Genome"), the following 'production' costs are accounted for:

In the case of costs covered by significant subsidies to a sequencing center (e.g., a grantee institution providing funds for purchasing large equipment), NHGRI has attempted to appropriately account for such costs in these analyses.

The costs associated with the following 'non-production' activities are not reflected in the two graphs:

In both graphs, the data from 2001 through October 2007 represent the costs of generating DNA sequence using Sanger-based chemistries and capillary-based instruments ('first generation' sequencing platforms). Beginning in January 2008, the data represent the costs of generating DNA sequence using 'second-generation' (or 'next-generation') sequencing platforms. The change in instruments represents the rapid evolution of DNA sequencing technologies that has occurred in recent years.

For the Sanger-based sequence data, the cost accounting reflects the generation of bases with a minimum quality score of Phred20 (or Q20), which represents an error probability of 1 % and is an accepted community standard for a high-quality base. For sequence data generated with second-generation sequencing platforms, there is not yet a single accepted measure of accuracy; each manufacturer provides quality scores that are, at this time, accepted by the NHGRI sequencing centers as equivalent to or greater than Q20.

In the "Cost per Megabase of DNA Sequence" graph, the data reflect the cost of generating raw, unassembled sequence data; no adjustment was made for data generated using different instruments despite significant differences in the sequence read lengths. In contrast, the "Cost per Genome" graph does take these differences into account since sequence read length influences the ability to generate an assembled genome sequence.

The "Cost per Genome" graph was generated using the same underlying data as that used to generate the "Cost per Megabase of DNA Sequence" graph; the former thus reflects an estimate of the cost of sequencing a human-sized genome rather than the actual costs for specific genome-sequencing projects.

To calculate the cost for sequencing a genome, one needs to know the size of that genome and the required 'sequence coverage' (i.e., 'sequence redundancy') to generate a high-quality assembly of the genome given the specific sequencing platform being used. For generating the "Cost per Genome" graph, the assumed genome size was 3,000 Mb (i.e., the size of a human genome). The assumed sequence coverage needed differed among sequencing platforms, depending on the average sequence read length for that platform.

For data since January 2008 (representing data generated using 'second-generation' sequencing platforms), the "Cost per Genome" graph reflects projects involving the 're-sequencing' of the human genome, where an available reference human genome sequence is available to serve as a backbone for downstream data analyses. The required 'sequence coverage' would be greater for sequencing genomes for which no reference genome sequence is available.

See: http://www.genome.gov/10001691

Mardis E. A decade's perspective on DNA sequencing technology. Nature, 470: 198-203. 2011. [PubMed]

Metzker M. Sequencing technologies - the next generation. Nature Genetics, 11: 31-46. 2010. [PubMed]

Stein L. The case for cloud computing in genome informatics. Genome Biology, 11: 207-213. 2010. [PubMed]

Human genome at ten: the sequence explosion. Nature, 464: 670-671. 2010. [PubMed]

Wetterstrand KA. DNA Sequencing Costs: Data from the NHGRI Genome Sequencing Program (GSP) Available at: http://www.genome.gov/sequencingcosts. Accessed [date of access].

Kris Wetterstrand, M.S. Scientific Liaison to the Director for Extramural Activities National Human Genome Research Institute, NIH Phone: 301-435-5543 E-mail: wettersk@mail.nih.gov

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Last Updated: October 2, 2015

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