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Skylab – Wikipedia, the free encyclopedia

Posted: March 9, 2016 at 6:43 pm

Skylab Skylab as photographed by its departing final crew (Skylab 4) Station statistics COSPAR ID 1973-027A Call sign Skylab Crew 3 per mission (9 total) Launch May 14, 1973 17:30:00 UTC Launch pad Kennedy Space Center LC-39A Reentry July 11, 1979 16:37:00 UTC near Perth, Australia Mission status Complete; uncontrolled re-entry Mass 150,300lb (68,175kg)[1] w/o Apollo CSM Length 82.4 feet (25.1m) w/o Apollo CSM Width 55.8 feet (17.0m) w/ one solar panel Height 36.3 feet (11.1m) w/ telescope mount Diameter 21.67 feet (6.6m) Pressurised volume 12,417cuft (351.6m3) Perigee 269.7mi (434.0km) Apogee 274.6mi (441.9km) Orbital inclination 50 Orbital period 93.4 min Orbits per day 15.4 Days in orbit 2,249 days Days occupied 171 days Number of orbits 34,981 Distance travelled ~890,000,000 mi (1,400,000,000 km) Statistics as of Re-entry July 11, 1979

Skylab was a space station launched and operated by NASA and was the United States' first space station. Skylab orbited Earth from 1973 to 1979, and included a workshop, a solar observatory, and other systems. It was launched unmanned by a modified Saturn V rocket, with a weight of 150,300 pounds (68,175kg).[1] Three manned missions to the station, conducted between 1973 and 1974 using the Apollo Command/Service Module (CSM) atop the smaller Saturn IB, each delivered a three-astronaut crew. On the last two manned missions, an additional Apollo / Saturn IB stood by ready to rescue the crew in orbit if it was needed.

The station was damaged during launch when the micrometeoroid shield separated from the workshop and tore away, taking one of two main solar panel arrays with it and jamming the other one so that it could not deploy. This deprived Skylab of most of its electrical power, and also removed protection from intense solar heating, threatening to make it unusable. The first crew was able to save it in the first in-space major repair, by deploying a replacement heat shade and freeing the jammed solar panels.

Skylab included the Apollo Telescope Mount, which was a multi-spectral solar observatory, Multiple Docking Adapter (with two docking ports), Airlock Module with EVA hatches, and the Orbital Workshop, the main habitable volume. Electrical power came from solar arrays, as well as fuel cells in the docked Apollo CSM. The rear of the station included a large waste tank, propellant tanks for maneuvering jets, and a heat radiator.

Numerous scientific experiments were conducted aboard Skylab during its operational life, and crews were able to confirm the existence of coronal holes in the Sun. The Earth Resources Experiment Package (EREP) was used to view Earth with sensors that recorded data in the visible, infrared, and microwave spectral regions. Thousands of photographs of Earth were taken, and records for human time spent in orbit were extended. Plans were made to refurbish and reuse Skylab, using the Space Shuttle to boost its orbit and repair it. However, development of the Shuttle was delayed, and Skylab reentered Earth's atmosphere and disintegrated in 1979, with debris striking portions of Western Australia. Post-Skylab NASA space laboratory projects included Spacelab, Shuttle-Mir, and Space Station Freedom (later merged into the International Space Station).

Rocket engineer Wernher von Braun, science fiction writer Arthur C. Clarke, and other early advocates of manned space travel, expected until the 1960s that a space station would be an important early step in space exploration. Von Braun participated in the publishing of a series of influential articles in Collier's magazine from 1952 to 1954, titled "Man Will Conquer Space Soon!". He envisioned a large, circular station 250 feet (75m) in diameter that would rotate to generate artificial gravity and require a fleet of 7,000-ton (6,500-metric ton) space shuttles for construction in orbit. The 80 men aboard the station would include astronomers operating a telescope, meteorologists to forecast the weather, and soldiers to conduct surveillance. Von Braun expected that future expeditions to the Moon and Mars would leave from the station.[2]:25

The development of the transistor, the solar cell, and telemetry, led in the 1950s and early 1960s to unmanned satellites that could take photographs of weather patterns or enemy nuclear weapons and send them to Earth. A large station was no longer necessary for such purposes, and the United States Apollo program to send men to the Moon chose a mission mode that would not need in-orbit assembly. A smaller station that a single rocket could launch retained value, however, for scientific purposes.[2]:5560

In 1959, von Braun, head of the Development Operations Division at the Army Ballistic Missile Agency, submitted his final Project Horizon plans to the U.S. Army. The overall goal of Horizon was to place men on the Moon, a mission that would soon be taken over by the rapidly forming NASA. Although concentrating on the Moon missions, von Braun also detailed an orbiting laboratory built out of a Horizon upper stage,[3]:23 an idea used for Skylab.[3]:9 A number of NASA centers studied various space station designs in the early 1960s. Studies generally looked at platforms launched by the Saturn V, followed up by crews launched on Saturn IB using an Apollo Command/Service Module,[3]:10 or a Gemini capsule[3]:14 on a Titan II-C, the latter being much less expensive in the case where cargo was not needed. Proposals ranged from an Apollo-based station with two to three men, or a small "canister" for four men with Gemini capsules resupplying it, to a large, rotating station with 24 men and an operating lifetime of about five years.[3]:1314 A proposal to study the use of a Saturn S-IVB as a manned space laboratory was documented in 1962 by the Douglas Aircraft Company.[4]

The Department of Defense (DoD) and NASA cooperated closely in many areas of space.[2]:198202 In September 1963, NASA and the DoD agreed to cooperate in building a space station.[3]:17 The DoD wanted its own manned facility, however,[2]:203 and in December it announced Manned Orbital Laboratory (MOL), a small space station primarily intended for photo reconnaissance using large telescopes directed by a two-man crew. The station was the same diameter as a Titan II upper stage, and would be launched with the crew riding atop in a modified Gemini capsule with a hatch cut into the heat shield on the bottom of the capsule.[3]:1719[5][6] MOL competed for funding with a NASA station for the next five years[3]:15 and politicians and other officials often suggested that NASA participate in MOL or use the DoD design.[2]:203 The military project led to changes to the NASA plans so that they would resemble MOL less.[3]:17

NASA management was concerned about losing the 400,000 workers involved in Apollo after landing on the moon in 1969.[3]:20,22 A reason von Braun, head of NASA's Marshall Space Flight Center during the 1960s, advocated for a smaller station after his large one was not built was that he wished to provide his employees with work beyond developing the Saturn rockets, which would be completed relatively early during Project Apollo.[2]:61 NASA set up the Apollo Logistic Support System Office, originally intended to study various ways to modify the Apollo hardware for scientific missions. The office initially proposed a number of projects for direct scientific study, including an extended-stay lunar mission which required two Saturn V launchers, a "lunar truck" based on the Lunar Module (LEM), a large manned solar telescope using a LEM as its crew quarters, and small space stations using a variety of LEM or CSM-based hardware. Although it did not look at the space station specifically, over the next two years the office would become increasingly dedicated to this role. In August 1965, the office was renamed, becoming the Apollo Applications Program (AAP).[3]:20

As part of their general work, in August 1964 the Manned Spacecraft Center (MSC) presented studies on an expendable lab known as Apollo "X", short for Apollo Extension System. "Apollo X" would have replaced the LEM carried on the top of the S-IVB stage with a small space station slightly larger than the CSM's service area, containing supplies and experiments for missions between 15 and 45 days' duration. Using this study as a baseline, a number of different mission profiles were looked at over the next six months.

In November 1964, von Braun proposed a more ambitious plan to build a much larger station built from the S-II second stage of a Saturn V. His design replaced the S-IVB third stage with an aeroshell, primarily as an adapter for the CSM on top. Inside the shell was a 10-foot (3.0m) cylindrical equipment section. On reaching orbit, the S-II second stage would be vented to remove any remaining hydrogen fuel, then the equipment section would be slid into it via a large inspection hatch. This became known as a "wet workshop" concept, because of the conversion of an active fuel tank. The station filled the entire interior of the S-II stage's hydrogen tank, with the equipment section forming a "spine" and living quarters located between it and the walls of the booster. This would have resulted in a very large 33-by-45-foot (10.1 by 13.7m) living area. Power was to be provided by solar cells lining the outside of the S-II stage.[3]:22

One problem with this proposal was that it required a dedicated Saturn V launch to fly the station. At the time the design was being proposed, it was not known how many of the then-contracted Saturn Vs would be required to achieve a successful Moon landing. However, several planned Earth-orbit test missions for the LEM and CSM had been canceled, leaving a number of Saturn IBs free for use. Further work led to the idea of building a smaller "wet workshop" based on the S-IVB, launched as the second stage of a Saturn IB.

A number of S-IVB-based stations were studied at MSC from mid-1965, which had much in common with the Skylab design that eventually flew. An airlock would be attached to the hydrogen tank, in the area designed to hold the LEM, and a minimum amount of equipment would be installed in the tank itself in order to avoid taking up too much fuel volume. Floors of the station would be made from an open metal framework that allowed the fuel to flow through it. After launch, a follow-up mission launched by a Saturn IB would launch additional equipment, including solar panels, an equipment section and docking adapter, and various experiments. Douglas Aircraft, builder of the S-IVB stage, was asked to prepare proposals along these lines. The company had for several years been proposing stations based on the S-IV stage, before it was replaced by the S-IVB.[3]:25

On April 1, 1966, MSC sent out contracts to Douglas, Grumman, and McDonnell for the conversion of a S-IVB spent stage, under the name Saturn S-IVB spent-stage experiment support module (SSESM).[3]:30 In May, astronauts voiced concerns over the purging of the stage's hydrogen tank in space. Nevertheless, in late July it was announced that the Orbital Workshop would be launched as a part of Apollo mission AS-209, originally one of the Earth-orbit CSM test launches, followed by two Saturn I/CSM crew launches, AAP-1 and AAP-2.

MOL remained AAP's chief competitor for funds, although the two programs cooperated on technology. NASA considered flying experiments on MOL, or using its Titan IIIC booster instead of the much more expensive Saturn IB. The agency decided that the Air Force station was not large enough, and that converting Apollo hardware for use with Titan would be too slow and too expensive.[3]:4548 The DoD later canceled MOL in June 1969.[3]:109

Design work continued over the next two years, in an era of shrinking budgets.[7] (NASA sought $450 million for Apollo Applications in fiscal year 1967, for example, but received $42 million.)[2]:6465 In August 1967, the agency announced that the lunar mapping and base construction missions examined by the AAP were being canceled. Only the Earth-orbiting missions remained, namely the Orbital Workshop and Apollo Telescope Mount solar observatory.

The success of Apollo 8 in December 1968, launched on the third flight of a Saturn V, made it likely that one would be available to launch a dry workshop.[2]:66 Later, several Moon missions were canceled as well, originally to be Apollo missions 18 through 20. The cancellation of these missions freed up three Saturn V boosters for the AAP program. Although this would have allowed them to develop von Braun's original S-II based mission, by this time so much work had been done on the S-IV based design that work continued on this baseline. With the extra power available, the wet workshop was no longer needed;[3]:109110 the S-IC and S-II lower stages could launch a "dry workshop", with its interior already prepared, directly into orbit.

[1]

A dry workshop simplified plans for the interior of the station.[3]:130Industrial design firm Raymond Loewy/William Snaith recommended emphasizing habitability and comfort for the astronauts by, for example, providing a wardroom for meals and relaxation,[3]:133134 and a window to view Earth and space, although astronauts who participated in Skylab planning were dubious about the designers' focus on areas such as color schemes.[3]:137 Habitability had not previously been an area of concern when building spacecraft, due to their small volume and brief mission durations, but the Skylab missions would last for months.[3]:133 NASA sent a scientist on Jacques Piccard's Ben Franklin submarine in the Gulf Stream in July and August 1969, to learn how six people would live in an enclosed space for four weeks.[3]:139140

Astronauts were uninterested in watching movies on a proposed entertainment center or playing games, but did want books and individual music choices.[3]:137 Food was also important; early Apollo crews complained about its quality, and a NASA volunteer found living on the Apollo food for four days on Earth to be intolerable; its taste and composition, in the form of cubes and squeeze tubes, were unpleasant. Skylab food significantly improved on its predecessors by prioritizing edibility over scientific needs.[3]:141142

Each astronaut had a private sleeping area the size of a small walk-in closet, with a curtain, sleeping bag, and locker.[8]:82 Designers also added a shower[3]:139[8]:80 and a toilet;[3]:152158[8]:30 the latter was both for comfort and to obtain precise urine and feces samples for examination on Earth.[3]:165

Rescuing astronauts from Skylab was possible in the most likely emergency circumstances. The crew could use the CSM to quickly return to Earth if the station suffered serious damage. If the CSM failed, the spacecraft and Saturn IB for the next Skylab mission would have been launched with two astronauts to retrieve the crew; given Skylab's ample supplies, its residents would have been able to wait up to several weeks for the rescue mission.[9]

On August 8, 1969, the McDonnell Douglas Corporation received a contract for the conversion of two existing S-IVB stages to the Orbital Workshop configuration. One of the S-IV test stages was shipped to McDonnell Douglas for the construction of a mock-up in January 1970. The Orbital Workshop was renamed "Skylab" in February 1970 as a result of a NASA contest.[3]:115 The actual stage that flew was the upper stage of the AS-212 rocket (the S-IVB stage - S-IVB 212). The mission computer used aboard Skylab was the IBM System/4Pi TC-1, a relative of the AP-101 Space Shuttle computers. A Saturn V originally produced for the Apollo program before the cancellation of Apollo 18, 19, and 20 was repurposed and redesigned to launch Skylab.[10] The Saturn V's upper stage was removed, but with the controlling Instrument Unit remaining in its standard position.

Skylab was launched on May 14, 1973 by the modified Saturn V. The launch is sometimes referred to as Skylab 1, or SL-1. Severe damage was sustained during launch and deployment, including the loss of the station's micrometeoroid shield/sun shade and one of its main solar panels. Debris from the lost micrometeoroid shield further complicated matters by pinning the remaining solar panel to the side of the station, preventing its deployment and thus leaving the station with a huge power deficit.[3]:253255

Immediately following Skylab's launch, Pad A at Kennedy Space Center Launch Complex 39 was deactivated, and construction proceeded to modify it for the Space Shuttle program, originally targeting a maiden launch in March 1979. The manned missions to Skylab would occur from Launch Pad 39B.

Three manned missions, designated SL-2, SL-3 and SL-4, were made to Skylab. The first manned mission, SL-2, launched on May 25, 1973 atop a Saturn IB and involved extensive repairs to the station. The crew deployed a parasol-like sunshade through a small instrument port from the inside of the station bringing station temperatures down to acceptable levels and preventing overheating that would have melted the plastic insulation inside the station and released poisonous gases. This solution was designed by NASA's "Mr. Fix It" Jack Kinzler, who won the NASA Distinguished Service Medal for his efforts. The crew conducted further repairs via two spacewalks (extra-vehicular activity, or EVA). The crew stayed in orbit with Skylab for 28 days. Two additional missions followed, with the launch dates of July 28, 1973 (SL-3) and November 16, 1973 (SL-4), and mission durations of 59 and 84 days, respectively. The last Skylab crew returned to Earth on February 8, 1974.

Skylab orbited Earth 2,476 times during the 171 days and 13 hours of its occupation during the three manned Skylab missions. Astronauts performed ten spacewalks, totaling 42 hours and 16 minutes. Skylab logged about 2,000 hours of scientific and medical experiments, 127,000 frames of film of the Sun and 46,000 of Earth.[3]:340 Solar experiments included photographs of eight solar flares, and produced valuable results[8]:155 that scientists stated would have been impossible to obtain with unmanned spacecraft.[3]:342344 The existence of the Sun's coronal holes were confirmed because of these efforts.[3]:357 Many of the experiments conducted investigated the astronauts' adaptation to extended periods of microgravity.

A typical day began at 6 AM Central Time Zone.[3]:307308 Although the toilet was small and noisy, both veteran astronautswho had endured earlier missions' rudimentary waste-collection systemsand rookies complimented it.[3]:165,307[8]:80[12] The first crew enjoyed taking a shower once a week, but found drying themselves in weightlessness[12] and vacuuming excess water difficult; later crews usually cleaned themselves daily with wet washcloths instead of using the shower. Astronauts also found that bending over in weightlessness to put on socks or tie shoelaces strained their stomach muscles.[3]:306308

Breakfast began at 7 AM. Astronauts usually stood to eat, as sitting in microgravity also strained their stomach muscles. They reported that their foodalthough greatly improved from Apollowas bland and repetitive, and weightlessness caused utensils, food containers, and bits of food to float away; also, gas in their drinking water contributed to flatulence. After breakfast and preparation for lunch, experiments, tests and repairs of spacecraft systems and, if possible, 90 minutes of physical exercise followed; the station had a bicycle and other equipment, and astronauts could jog around the water tank. After dinner, which was scheduled for 6 PM, crews performed household chores and prepared for the next day's experiments. Following lengthy daily instructions (some of which were up to 15 meters long) sent via teleprinter, the crews were often busy enough to postpone sleep.[3]:309,334[13]:27

Each Skylab mission set a record for the amount of time astronauts spent in space. The station offered what a later study called "a highly satisfactory living and working environment for crews", with enough room for personal privacy.[13]:24 Although it had a dart set,[14]playing cards, and other recreational equipment in addition to books and music players, the window with its view of Earth became the most popular way to relax in orbit.[8]:7980,134135

Overview of most major experiments:[15] Skylab 3 carried several more experiments, such as to observe Comet Kohoutek.

Skylab was abandoned after the end of the SL-4 mission in February 1974, but to welcome visitors the crew left a bag filled with supplies and left the hatch unlocked.[16] NASA discouraged any discussion of additional visits due to the station's age,[3]:335,361 but in 1977 and 1978, when the agency still believed the Space Shuttle would be ready by 1979, it completed two studies on reusing the station.[13]:3-1[16] By September 1978, the agency believed Skylab was safe for crews, with all major systems intact and operational.[13]:3-2 It still had 180 man-days of water and 420 man-days of oxygen, and astronauts could refill both;[16] the station could hold up to about 600 to 700 man-days of drinkable water and 420 man-days of food.[13]:27

The studies cited several benefits from reusing Skylab, which one called a resource worth "hundreds of millions of dollars"[13]:113 with "unique habitability provisions for long duration space flight."[13]:311 Because no more operational Saturn V rockets were available after the Apollo program, four to five shuttle flights and extensive space architecture would have been needed to build another station as large as Skylab's 12,400 cubic feet (350m3) volume.[13]:1-12 to 1-13 Its ample sizemuch greater than that of the shuttle alone, or even the shuttle plus Spacelab[13]:28was enough, with some modifications, for up to seven astronauts[13]:231 of both sexes,[13]:314 and experiments needing a long duration in space;[13]:113 even a movie projector for recreation was possible.[13]:311

Proponents of Skylab's reuse also said repairing and upgrading Skylab would provide information on the results of long-duration exposure to space for future stations.[16] The most serious issue for reactivation was stationkeeping, as one of the station's gyroscopes had failed[3]:361 and the attitude control system needed refueling; these issues would need EVA to fix or replace. The station had not been designed for extensive resupply. However, although it was originally planned that Skylab crews would only perform limited maintenance[8]:34 they successfully made major repairs during EVA, such as the SL-2 crew's deployment of the solar panel[8]:7375 and the SL-4 crew's repair of the primary coolant loop.[3]:317[8]:130[13]:321 The SL-2 crew fixed one item during EVA by, reportedly, "hit[ting] it with [a] hammer."[8]:89

Some studies also said, beyond the opportunity for space construction and maintenance experience, reactivating the station would free up shuttle flights for other uses,[13]:113 and reduce the need to modify the shuttle for long-duration missions.[13]:2-9 to 2-10 Even if the station were not manned again, went one argument, it would serve as a useful experimental platform.[13]:261

The reactivation would likely have occurred in four phases:[16]

The first three phases would have required about $60 million in 1980s dollars, not including launch costs.

After a boost of 6.8 miles (10.9km) by SL-4's Apollo CSM before its departure in 1974, Skylab was left in a parking orbit of 269 miles (433km) by 283 miles (455km)[3]:361 that was expected to last until at least the early 1980s, based on estimates of the 11-year sunspot cycle that began in 1976.[3]:361[20] NASA began considering the potential risks of a space station reentry as early as 1962, but decided to not incorporate a retrorocket system in Skylab due to cost and acceptable risk.[3]:127129

The spent 49-ton Saturn V S-II stage which had launched Skylab in 1973 remained in orbit for almost two years, and made an uncontrolled reentry on January 11, 1975.[21] Some debris, most prominently the five heavy J-2 engines, likely survived to impact in the North Atlantic Ocean. Although this event did not receive heavy media or public attention, it was followed closely by NASA and the Air Force, and helped emphasize the need for improved planning and public awareness for Skylab's eventual reentry.[citation needed]

British mathematician Desmond King-Hele of the Royal Aircraft Establishment predicted that Skylab would de-orbit and crash to earth due to increased solar activity. NASA initially denied this but accepted after his calculations were checked.[citation needed] Greater-than-expected solar activity[3]:362 heated the outer layers of Earth's atmosphere and increased drag on Skylab. By late 1977, NORAD accurately forecast a reentry in mid-1979;[20] a National Oceanic and Atmospheric Administration (NOAA) scientist criticized NASA for using an inaccurate model for the second most-intense sunspot cycle in a century, and for ignoring NOAA predictions published in 1976.[3]:362363

The reentry of the USSR's nuclear powered Cosmos 954 in January 1978, and the resulting radioactive debris fall in northern Canada, drew more attention to Skylab's orbit. Although Skylab did not contain radioactive materials, the State Department warned NASA about the potential diplomatic repercussions of station debris.[3]:363Battelle Memorial Institute forecast that up to 25 tons of metal debris could land in 500 pieces over an area 4,000 miles long and 1,000 miles wide. The lead-lined film vault, for example, might land intact at 400 feet per second.[22]

Ground controllers re-established contact with Skylab in March 1978[20] and recharged its batteries.[23] Although NASA worked on plans to reboost Skylab with the Space Shuttle through 1978 and the TRS was almost complete, the agency gave up in December when it became clear that the shuttle would not be ready in time;[3]:363367[17] its first flight, STS-1, did not occur until April 1981. Also rejected were proposals to launch the TRS using one or two unmanned rockets[16] or to attempt to destroy the station with missiles.[22]

Skylab's demise was an international media event, with merchandising of T-shirts and hats with bullseyes,[22] wagering on the time and place of re-entry, and nightly news reports. The San Francisco Examiner offered a $10,000 prize for the first piece of Skylab delivered to its offices; the competing Chronicle offered $200,000 if a subscriber suffered personal or property damage.[23] NASA calculated that the odds of station re-entry debris hitting any human were 1 to 152 and when multiplied by 4 billion becomes 1 in 600 billion for a specific human,[24] although the odds of debris hitting a city of 100,000 or more were 1 to 7 and special teams were readied to head to any country hit by debris and requesting help.[23]

We assume that Skylab is on the planet Earth, somewhere.

In the hours before re-entry, ground controllers adjusted Skylab's orientation to try to minimize the risk of re-entry on a populated area.[23] They aimed the station at a spot 810 miles (1,300km) south southeast of Cape Town, South Africa, and re-entry began at approximately 16:37 UTC, July 11, 1979.[3]:371 The Air Force provided data from a secret tracking system able to monitor the reentry.[25] The station did not burn up as fast as NASA expected, however. Due to a 4% calculation error, debris landed southeast of Perth, Western Australia,[3]:371 and was found between Esperance and Rawlinna, from 31 to 34S and 122 to 126E, about 130150km radius around Balladonia. Residents and an airline pilot saw dozens of colorful fireworks-like flares as large pieces broke up in the atmosphere.[22] The Shire of Esperance facetiously fined NASA A$400 for littering, a fine which remained unpaid for 30 years.[26] The fine was paid in April 2009, when radio show host Scott Barley of Highway Radio raised the funds from his morning show listeners and paid the fine on behalf of NASA.[27][28]

Seventeen-year-old Stan Thornton found 24 pieces of Skylab at his home in Esperance. A Philadelphia businessman flew him, his parents, and his girlfriend to San Francisco, where he collected the Examiner prize.[3]:371[22] In a coincidence for the organizers, the annual Miss Universe pageant was scheduled to be held a few days later, on July 20, 1979 in Perth. A large piece of Skylab debris was displayed on the stage.[29] Analysis of the debris showed that the station had not disintegrated until 10 miles above the Earth, much lower than expected.[22]

After the demise of Skylab, NASA focused on the reusable Spacelab module, an orbital workshop that could be deployed with the Space Shuttle and returned to Earth. The next American major space station project was Space Station Freedom, which was merged into the International Space Station in 1993, and launched starting in 1998. Shuttle-Mir was another project, and led to the U.S. funding Spektr, Priroda, and the Mir Docking Module in the 1990s.

Skylab 5 would have been a short 20-day mission to conduct scientific experiments and boost Skylab into a higher orbit. Vance Brand (commander), William B. Lenoir (science pilot), and Don Lind (pilot) would have been the crew for this mission, with Brand and Lind being the prime crew for the Skylab Rescue flights.[30] Brand and Lind also trained for a mission that would have aimed Skylab for a controlled deorbit.[25]

In addition to the flown Skylab space station, a second flight-quality backup Skylab space station had been built during the program. NASA considered using it for a second station in May 1973 or later, to be called Skylab B (S-IVB 515), but decided against it. Launching another Skylab with another Saturn V rocket would have been very costly, and it was decided to spend this money on the development of the Space Shuttle instead. The backup is on display at the National Air and Space Museum in Washington, D.C.

A full-size training mock-up once used for astronaut training is located at the Lyndon B. Johnson Space Center visitor's center in Houston, Texas. Another full-size training mock-up is at the U.S. Space & Rocket Center in Huntsville, Alabama. Originally displayed indoors, it was subsequently stored outdoors for several years to make room for other exhibits. To mark the 40th anniversary of the Skylab program, the Orbital Workshop portion of the trainer was restored and moved into the Davidson Center in 2013.[31][32] NASA transferred the backup Skylab to the National Air and Space Museum in 1975. On display in the Museum's Space Hall since 1976, the orbital workshop has been slightly modified to permit viewers to walk through the living quarters.[33]

The numerical identification of the manned Skylab missions was the cause of some confusion. Originally, the unmanned launch of Skylab and the three manned missions to the station were numbered SL-1 through SL-4. During the preparations for the manned missions, some documentation was created with a different scheme -- SLM-1 through SLM-3for those missions only. William Pogue credits Pete Conrad with asking the Skylab program director which scheme should be used for the mission patches, and the astronauts were told to use 1-2-3, not 2-3-4. By the time NASA administrators tried to reverse this decision, it was too late, as all the in-flight clothing had already been manufactured and shipped with the 1-2-3 mission patches.[34]

From 1966 to 1974, the Skylab program cost a total of $2.2 billion or $10 billion in 2010 dollars with inflation. As its three three-man crews spent 510 total man-days in space, each man-day cost approximately $20 million in 2010 dollars, compared to $7.5 million for the International Space Station.[35]

An astronaut mannequin dines aboard the backup Skylab at the Smithsonian NASM.

SkyLab commemorative stamp, Issue of 1974. The commemorative stamp reflects initial repairs to the station, including the parasol sunshade.

Vanguard (T-AGM-19) seen as a NASA Skylab tracking ship. Note the tracking radar and telemetry antennas.

Robbins Medallions issued for Skylab Missions.

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Biology/DNA

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Forensic scientists analyze biological evidence to help solve a variety of crimes. These analyses can show that biological materials from a specific individual was found at a crime scene, can help inform how a victim may have died, and can even bring identity to unknown human remains found in advanced stages of decomposition. Forensic biology is used to determine what types of biological stains, such as blood or semen, are left at a crime scene and to link those stains to individuals through DNA analysis.

Partnership with Applied Genetics Group We work closely with the NIST Applied Genetics Group, which focuses on developing standards and technology to support the use of DNA testing in human identification. For example, with the Applied Genetics Group, we helped develop Standard Reference Material for DNA profiling to ensure that forensic laboratories produce consistent results. We also supported their research to enable forensic scientists to obtain DNA profiles from items that have previously been unsuccessful in yielding DNA results using conventional DNA analysis markers. This has enabled more information to be entered into DNA databases, which is useful when attempting to provide leads in unsolved crimes with degraded evidence and establishing the identity of victims after a mass disaster. In addition, we supported the Applied Genetics Group efforts to improve the processes used to evaluate evidence items that contain DNA mixtures and their research to speed up the forensic DNA analysis process.

Technical Working Group on Biological Evidence PreservationThe proper long-term storage and preservation of biological evidence has become increasingly newsworthy as states throughout the U.S. enact legislation allowing post-conviction DNA testing of evidence. In August 2010, we partnered with the National Institute of Justice to lead the Technical Working Group on Biological Evidence Preservation, which examines current policies, procedures, and practices in biological evidence collection, storage, and preservation. The primary objective of the working group was to establish best practices, based in science, to reduce the premature destruction and degradation of biological evidence, thus ensuring its availability for future analysis.

The Technical Working Group on Biological Evidence Preservation has released The Biological Evidence Preservation Handbook: Best Practices for Evidence Handlers. The Handbook addresses packaging and storage, tracking and chain of custody, and disposition of biological evidence. For more information on the Handbook and the working group, visit the Technical Working Group on Biological Evidence Preservation's page.

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The Selfish Gene (Popular Science): 9780192860927 …

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Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands of readers to rethink their beliefs about life. In his internationally bestselling, now classic volume, The Selfish Gene, Dawkins explains how the selfish gene can also be a subtle gene. The world of the selfish gene revolves around savage competition, ruthless exploitation, and deceit, and yet, Dawkins argues, acts of apparent altruism do exist in nature. Bees, for example, will commit suicide when they sting to protect the hive, and birds will risk their lives to warn the flock of an approaching hawk. This revised edition of Dawkins' fascinating book contains two new chapters. One, entitled "Nice Guys Finish First," demonstrates how cooperation can evolve even in a basically selfish world. The other new chapter, entitled "The Long Reach of the Gene," which reflects the arguments presented in Dawkins' The Extended Phenotype, clarifies the startling view that genes may reach outside the bodies in which they dwell and manipulate other individuals and even the world at large. Containing a wealth of remarkable new insights into the biological world, the second edition once again drives home the fact that truth is stranger than fiction.

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The Selfish Gene (Popular Science): 9780192860927 ...

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Contact Us – Welcome to the Department of Genetics at …

Posted: March 8, 2016 at 7:45 pm

Mailing Addresses

Main Departmental Office: Human Genetics Institute Life Sciences Building 145 Bevier Road Piscataway, NJ 08854-8082

Undergraduate Departmental Office: Department of Genetics, Nelson Bio Labs-B416 604 Allison Road Piscataway, NJ 08854-8082

Dr. Linda Brzustowicz - Chair This email address is being protected from spambots. You need JavaScript enabled to view it. (P) 848-445-1638 (F) 732-445-1636

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Contact Us - Welcome to the Department of Genetics at ...

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Genome Sequencing – joshuatreegenome.org

Posted: March 7, 2016 at 5:46 pm

What is a genome?

An organisms genome is the total set of DNA it inherits from its parents. The genome includes genes and non-coding DNA sequence as well as epigenetic modifications, such as methylation. The regulated expression of these genetic elements provides the building blocks and instructions through which an organism develops, grows, and interacts with its environment.

The DNA sequence of a genome sequence provides context. By sequencing the genome of Joshua Tree, we will have a global view of the genes and regulatory elements that code for the chemical building blocks of a Joshua tree and control how it grows and responds to its environment. Knowing the genome sequence, we can begin to conduct experiments and analyses that can identify specific regions of that sequence that are important for Joshua trees interactions with pollinating moths and other members of the Mojave desert biological community, and its adaptation to desert climates.

Joshua trees genome is approximately three billion DNA bases in length thats as many characters as there are in more than 2,500 copies of Moby Dick. Current technology doesnt allow us to simply read such a long DNA sequence from one end to the other; instead, DNA sequencing methods collect many smaller snippets of DNA sequence, which we can then assemble into a whole-genome sequence. We will use a hybrid assembly approach for the Joshua tree genome by combining the power of two DNA sequencing technologies. Illumina sequencing can collect large quantities of DNA sequence data, but in small snippets of just a couple hundred DNA bases. The PacBio method reads long continuous stretches of DNA sequence, though it cant collect as much total data as Illumina. Through our collaborators, we have access to PacBio sequencing capacity, and were crowd-funding the collection of Illumina data to complete the assembly. We will incorporate a new optical mapping method from BioNano to help assemble this sequence data into the full genome sequence.

When we have completed genome assembly from Illumina and PacBio sequencing, we will annotate the genome to identify genes and other functional elements. Ultimately we will build a transcriptions atlas of which genome regions play roles in development of different parts of a Joshua tree, and which control the trees growth and responses to its environment. This will provide a foundation to explore form and function within Joshua tree, from questions of how the genome functions as a whole to identifying genes that shape the interaction between Joshua tree and its pollinators.

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DNA and the genome – BioWiki

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A major news story over recent years has been the announcement of the genome sequence for humans. In fact, this project reached a symbolic completion point in April 2003. But this human genome work is just part of a much bigger story -- which includes a list of many completed genomes, for microbes, plants and animals. All this genome work is just the beginning; genome information alone does not solve anything in particular; it is a big resource that will make further biological work easier.

Two major news stories of 2003 set the background for this discussion. One is the 50th anniversary of the announcement of the double helical structure of DNA. The other is the announcement of the completed DNA sequence for the human genome. We discussed the development of the DNA structure. A key idea that emerged from this is the complementarity of the two DNA strands. This complementarity immediately suggests how DNA replicates -- by the two strands separating and each serving as a template for a new strand. The resulting "daughter" DNA molecules have one "old" strand and one "new" strand. A physical test of replicated DNA, showing this characteristic, was key in "proving" the basic DNA model. There is much chemical complexity to DNA and much biochemical complexity to how DNA really replicates, but the basic logic of a double stranded structure held together by complementarity still holds.

We then discussed DNA sequencing. We started by looking at some simple DNA sequencing results -- and showed how easy it is to actually read the sequence. Of course, what we looked at is the end step of a lengthy series of steps. We discussed an example of how one might generate the pattern we saw on the sequencing film; our example was not what is actually done, but was a simpler variation to illustrate the logic. The main problem with this basic sequencing procedure is that it works for only about 500 bases. Thus sequencing larger genomes requires some additional work, but it is still based on the same classical procedure that we started with. For large genomes, the process is highly automated, including the use of lasers to read dye-coded bases. Further, tremendous computer capability is needed to keep track of the data from the millions of pieces of DNA that are individually sequenced.

We discussed the gene count for humans. It is rather low -- and also uncertain. It is uncertain because we actually have considerable difficulty recognizing genes simply from DNA sequences, especially for complex organisms. The low gene count is forcing us to emphasize complexities in gene function, such as splicing and editing, that allow more than one protein to be made from a gene. We then discussed applications of genome information, especially of genome differences between individuals. These include applications such as forensic testing and paternity testing, which were developed some time ago. We discussed some drugs which are chosen based on specific genetic characteristics -- either of the individual, or even of the particular cancer. We then discussed more recent work, using gene chips (microarrays), where analysis of many genes allows leukemia (or leprosy) sub-types to be recognized. The specific figure that I showed was from a recent supplement to The Scientist: New Frontiers in Cancer Research, Sept 22, 2003. One topic that came up during general discussion was prions; I now have a page on prions.

The human genome is made of DNA -- as is the genome of almost all organisms. (A few viruses use the closely related chemical, RNA, for their genome; RNA operates by the same basic principles as DNA in this role.) A major milestone in the history of DNA is being celebrated in 2003 (the year this page was started)... It was fifty years ago, April 1953, that Watson & Crick announced that they had determined the structure of DNA -- a structure that in fact "made clear" how it works.

This Fig is from the Glossary of the NIH genome site, http://www.genome.gov/glossary/index.cfm?. Choose deoxyribonucleic acid (DNA). Also see next Fig.

In this Fig, the "replication fork" (the site and apparatus for making new DNA) is moving upward.

This Fig is also from the Glossary of the NIH genome site, http://www.genome.gov/glossary/index.cfm?. Choose DNA replication.

Good overview of DNA, by David Goodsell. This is a "Molecule of the Month" feature at the Protein Data Bank. http://www.rcsb.org/pdb/101/motm.do?momID=23. For more, see http://ndbserver.rutgers.edu/education/index.html. This is from the educational resources of The Nucleic Acid Database Project at Rutgers.

The double helix structure was published by Watson and Crick in 1953 in the journal Nature. 2003 is the 50th anniversary of that landmark, and there are many commemorations. The January 23, 2003, issue of Nature has a big feature on this. It includes an introductory article (Nature 421:310), copies of the original papers on DNA structure, and many articles discussing various aspects of the DNA story. And then there is more in the April 24, 2003, issue. This includes an article (Nature 422:835) by Francis Collins et al on the future of the human genome project. Fig 1 of that article is a fold-out timeline "Landmarks in Genetics and Genomics"; this is available as a pdf file from the Nature web site. At least some of this material could be usefully read or browsed by those with little background in the field.

* Nature is available online at http://www.nature.com/index.html. * The Nature "web focus" Double helix: 50 years of DNA ... http://www.nature.com/nature/dna50/index.html. * A Nature News Special on the DNA Anniversary ... http://www.nature.com/news/specials/dna50/index.html.

Among other web sites that resulted from the commemoration of the DNA anniversary...

The human genome was officially announced in February 2001 by two groups.

The main genome articles are probably too technical for most, but the issues contain many news stories dealing with various aspects of the project.

The Human Genome. A genome site from the Burroughs Wellcome Trust, which supported much of the British part of the genome project. http://genome.wellcome.ac.uk/. Includes a range of information at various levels, including for the general public.

Nature: Human Genome Collection. http://www.nature.com/nature/supplements/collections/humangenome/index.html. Links to all human genome work from Nature journals. Much consists of the technical articles, but there are also news stories and discussions.

Neandertal genome. February 2009 brings the announcement of a genome sequence from a 38,000 year old Neandertal. It is actually fairly rough at this point, but it is a remarkable achievement to get this far. There is little to conclude for now, except that the genome evidence so far provides no evidence for interbreeding between Neandertals and modern man (Homo sapiens).

Genome results are so important and fascinating that rodents have been seen scrutinizing their genome data. http://news.bbc.co.uk/2/hi/science/nature/424076.stm. (My main purpose in giving this link is for the Figure, for fun. But the work described there is an example of moving a gene from one organism to another, and using that as a tool to learn about the characteristics of an organism.)

As noted earlier, the genome is just data. It is not the magic solution to anything in particular. Because the genome data is fairly new, in fact few practical advances can be directly attributed to it. So, much of what I do here is to show how genome info might be used.

Pharmacogenomics and nutrigenomics. Traditional recommendations about proper nutrition and medicine assume that the population is uniform. Data is collected about population averages and this is used to guide medical treatments and nutritional advice. But we are not all the same. In fact, some examples of genetic differences in how we respond to drugs or nutrients have been found, more or less accidentally, in the past. The availability of complete genome information will allow such knowledge to come more rapidly. Briefly, pharmacogenomics is the customization of drug usage depending on an individual's genetic makeup; nutrigenomics is the analogous customization of nutrition information depending on an individual's genetic makeup.

The following two items are major nutrigenomics sites:

* The Center of Excellence for Nutritional Genomics at UC Davis, supported by the NCMHD (National Center for Minority Health and Health Disparities, part of the NIH) : http://nutrigenomics.ucdavis.edu.

* The European Nutrigenomics Organisation (NuGO): http://www.nugo.org/everyone/. In particular, see their page http://www.nugo.org/nip/ for the Nutrigenomics Information Portal, then choose Research. Also, they have an electronic newsletter. You can read it online, or sign up to receive it by email; choose NutriAlerts from the "NuGO sites" menu at the left (of either of those pages).

The two sites above are also listed on my page Further reading: Medical topics, under Web Sites. A specific page of the NuGO site, on Adipose Tissue, is listed for Organic/Biochemistry Internet resources, under Lipids.

The Future of Nutrigenomics - From the Lab to the Dining Room. A brochure for the general public, from the Institute for the Future. March 2005. http://www.iftf.org/node/773.

Cancer. Two articles on work to classify cancers by gene expression patterns. This work has implications for customizing treatment. A Gianella-Borradori et al, Reducing risks, maximizing impact with cancer biomarkers and B A Maher, The makings of a microarray prognosis. The Scientist Mar 15, 2004, pp 8 & 32.

Race. Is "race" a useful criterion for guiding medical treatment? The important point for us here is that genomics is offering new insight into this socially-charged question. At this point, genetic analysis suggests that there are some genes that reflect "geographical origin", but that the variability of human genomes within any "race" is far more than the genetic differences between "races". Of course, this information will be of more practical use as details emerge.

The following New York Times article discusses a clinical trial of a drug that is being targeted to and tested with only one racial group -- with the approval of the FDA. U.S. to Review Heart Drug Intended for One Race, June 2005. http://www.nytimes.com/2005/06/13/business/13cardio.html.

The following two short essays are by scientists discussing the race issue:

Personalized medicine. There are now companies that will take your DNA (and some money) and report back to you your risk for certain diseases. A good idea in principle, but how good is it in practice. Genome pioneer Craig Venter and colleagues have evaluated a couple of these companies, and offer some suggestions. As a general perspective, they think the companies are doing high quality work, technically, but the quality and usefulness of the information is questionable. It is true that your DNA contains information about disease susceptibility, but current knowledge of that is limited -- more limited than the companies want to admit. The paper is: P C Ng et al, An agenda for personalized medicine. Nature 461:724, 10/8/09. The paper seems to be freely available via the web site of the Venter Institute. Go to their page of press releases: http://www.jcvi.org/cms/press/press-releases/. Scroll down to the item for October 7, 2009. Click on its link; it takes you directly to the article at Nature. This probably means that the article is freely available directly from Nature.

Added May 7, 2011. There are many Musings posts in the broad area of personalized medicine. One of the first was: Personalized medicine: Getting your genes checked (10/27/09). It links to several others in the area.

An Introduction to Genomics: The Human Genome and Beyond, and related educational materials on the how and why of sequencing. From the Joint Genome Institute, a US DOE lab in Walnut Creek, CA. http://www.jgi.doe.gov/education/index.html.

Genetics Home Reference, an educational site on genetic diseases in humans; from the National Library of Medicine. http://ghr.nlm.nih.gov.

Book. J D Watson (with A Berry), DNA - The Secret of Life. Knopf, 2003. Watson has played a major role in the DNA story, most famously as co-discoverer of the DNA double helical structure and as the first head of the US Human Genome Project. Here he discusses the history and future of the human genome project. He is a fine writer -- clear, and provocative enough to be fun. This book is for the general public. The science in it is good, and well-explained, with helpful artwork. The history is broadly good. And it is Watson's style to tell you what he thinks about controversial issues; agree or disagree, he makes for lively reading. For two -- very different -- reviews: Lindee, Science 300:432, 4/18/03; Singer, Nature 422:809, 4/24/03. Lindee concludes that "[Watson's] latest promotional brochure is not worth anyone's time." Singer says that the public and even scientists "can learn a great deal from the book, and enjoy doing so." I recommend it -- without endorsing all of his opinions.

Online video. A conversation with Jim Watson. Go to the Caltech theater listings for Science and Technology: http://today.caltech.edu/theater/list?subset=science&story%5fcount=end. Scroll down the list to this item, dated May 5, 2003. The conversation is with David Baltimore, (then) president of Caltech and himself a Nobel prize winner (for his discovery of the enzyme reverse transcriptase, the enzyme that copies RNA into DNA).

Book. B Maddox, Rosalind Franklin - The dark lady of DNA. Harper/Collins, 2002. One of the dark parts of the DNA story is the lack of recognition of the role of Rosalind Franklin, who made the very fine X-ray pictures that Watson & Crick used as part of developing the double-helix structure. This lack of recognition was magnified by Watson's poor treatment of Franklin, especially in his earlier book, The Double Helix. Brenda Maddox's new biography has received wide praise as being fair and accurate; she had access to many materials that were previously unavailable. This is a biography, not a science book -- though you will certainly get a good sense of how the DNA story was developed. Highly recommended, but don't expect to come away declaring winners and losers; it's not that simple, but it is a good story, and it certainly enhances our understanding of an important scientist. (One part of the controversy, to some, is why Franklin did not share in the Nobel prize for the DNA work. It is a sufficient answer to that question that she died a few years before the DNA Nobel, 1962; posthumous Nobels are not allowed. Note that this point does not address the merits of her contributions, but does address one question which often comes to the forefront.)

There is a short essay about Franklin, in the general spirit of the book, online in the Mill Hill collection: K Rittinger & A Pastore, Rosalind Franklin - The dark lady of DNA... http://www.nimr.mrc.ac.uk/mill-hill-essays/rosalind-franklin-the-dark-lady-of-dna. For more about the Mill Hill essays, see the note on the BITN main page, under Web sites.

Coumadin (warfarin) is a widely prescribed medication to reduce blood clotting. The dosage must be carefully controlled, and people vary in how they respond. The FDA has announced a new labeling of coumadin that encourages testing the patient for two known genetic factors that affect the metabolism of the drug. A brief version of the announcement is at http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm152972.htm.

A small trial has been reported showing that such testing is beneficial. So far, all we have is a news story summarizing the key findings. Gene test cuts complications from blood thinner warfarin (3/16/10). http://www.usatoday.com/news/health/2010-03-16-warfarin-gene_N.htm.

Sequencing technology -- and cost. The human genome project cost about $3 billion. Much technology was developed along the way; as the project wrapped up, it was estimated that one could sequence a person's genome for a few million dollars. There is a dream -- and goal -- of sequencing an individual's genome for a thousand dollars. That may still be a way off, but the cost of sequencing has been declining, in large part due to fundamentally new approaches to sequencing. 2009 brings a report of a complete human genome for $50,000. A news story on this: Cost of Decoding a Genome Is Lowered. A Stanford engineer has invented a new technology for decoding DNA and used it to decode his own genome for less than $50,000. August 10, 2009. http://www.nytimes.com/2009/08/11/science/11gene.html.

Using genetic information to assess risk and guide screening. Most genes that affect disease susceptibility have only a small effect. How do we use such information? A paper in the New England Journal of Medicine lays out a model. Although there is probably much to quibble with, the model is clear enough, and may be a useful reference point for discussion. They start with the current UK recommendation that women be screened for breast cancer starting at age 50. Accepting this as the starting point, they note that this is the point at which a woman has a 2.3% chance of breast cancer within the next 10 years. They then argue that by a simple test for some known genetic variants, they can mark some women for screening at age 40 -- because with their genetic makeup that is the age at which they now have a 2.3% risk of breast cancer within 10 years. Similarly, women with other genetic variants have lower risk, and their screening can be delayed. The result is the same use of resources, but more effectively deployed. A news story about this work: Cancer gene test 'for all women', June 26, 2008. Online: http://news.bbc.co.uk/2/hi/health/7475312.stm. The paper is P D P Pharoah et al, Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer. N Engl J Med 358:2796, 6/26/08. Free online: http://www.nejm.org/doi/full/10.1056/NEJMsa0708739.

Tradeoff. We sometimes dream of finding "the gene" that causes a particular disease -- so we can counteract that gene. But among the complications... It may be that the same gene is good in one way and bad in another. Recent work suggests such a tradeoff may occur between diabetes and prostate cancer. In fact, two genes with this tradeoff have been found. News story: Genetic variants may be 'trading' one illness with another using new genes, Oxford research shows. Online: http://www.timesonline.co.uk/tol/news/science/article3649020.ece.

Genome ethics. Genome work is raising a new set of ethics questions -- especially since there is so much uncertainty what the genome information means at this point. A group of bioethicists has proposed a set of guidelines for doing genome research, published as: T Caulfield et al, Research Ethics Recommendations for Whole-Genome Research: Consensus Statement. PLOS Biology 6, e73, 3/08. The paper is free online: http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0060073.

Ancestry. An interesting subject is tracing human lineages by genetic tests. This is indeed a proper area of study, and has yielded insights into human migrations. It has also entered the popular arena. There are commercial tests that claim to reveal your ancestry. Unfortunately, the quality of this testing is questionable at this point. A "Policy Forum" article about this appeared in Science, and a news story about the work and that article appeared in the UC Berkeley news. The Science article: D A Bolnick et al, Genetics: The science and business of genetic ancestry testing. Science 318:399, 10/19/07. The UC Berkeley news story, featuring co-author Kimberly TallBear: Researchers caution against genetic ancestry testing; October 18, 2007. http://www.berkeley.edu/news/media/releases/2007/10/18_genetictesting.shtml.

Craig Venter is one of the pioneers of genome work. He is also the first person to have his entire DNA -- the diploid chromosome set -- completely sequenced and reported. Importance? Well, for now it is a technical milestone and something of a curiosity. However, as more complete genomes become available -- and as the cost comes down -- the usefulness will increase. For example, they note how he has specific alleles that both favor and disfavor heart disease. At this point, that is too little info to be useful. At some point, with more information, it will be useful. I doubt that many will want to read this in detail, but simply browsing the Introduction and Discussion sections will give the flavor. And it is a historic paper. The paper -- by Venter, about Venter, and from the Venter Institute -- is: S Levy et al, The Diploid Genome Sequence of an Individual Human. PLoS Biol 5(10): e254. 9/4/07. It is open access at http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0050254.

M May, Pharmacogenetics lurches forward. The Scientist 8/2/04, p 26. This article discusses several specific examples of how drugs may affect individuals differently, depending on their genetics. It includes the recent genetic analysis of why Iressa works for some patients and not others.

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DNA and the genome - BioWiki

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MOTIVATION GENOME – Home

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Internal Drive Theory:Motivate your child to WANT to study This book documents 11 different motivation strategies, each inspired by an established stream of research in the field of Human Motivation. These strategies are designed to bring about Internal Drive Ignition(TM) in children. They form part of a larger basket of strategies that Dr Petunia Lee uses to ignite internal drive in children. Each research-inspired strategy is explained simply and illustrated with real-life anecdotes in order to paint the hows and whys of its use in vivid detail. Used together, these strategies may help families save money on tuition because a motivated child is half the battle won. It is hoped that these strategies will sweeten the lives of many children by enhancing the motivation skills of parents. This is a book worth buying because it brings gentleness and love back into motivation and shows that these two are far more effective motivators than fear, bribes and nagging. Successful use of these strategies also strengthens family relationships. The rewards from the use of these strategies will be reaped for many long years after the child has left school.

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MOTIVATION GENOME - Home

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Ron Mason – Wikipedia, the free encyclopedia

Posted: March 6, 2016 at 8:41 pm

Ronald Mason (born January 14, 1940) is a Canadian former ice hockey player, head coach and university executive. A head coach of various American universities, most notably Michigan State University (MSU), he was the most successful coach in NCAA ice hockey history between 1993-2012 with 924 wins, until Jerry York (Boston College) become the new winningest coach with his 925th career win on December 29, 2012.[1] Mason was athletic director at MSU from 2002-08. He currently serves as senior advisor for the USHL Muskegon Lumberjacks.[2] On December 2, 2013, Mason was inducted into the U.S Hockey Hall of Fame.

Ron Mason was born the son of Harvey Mason, a salesman, and Agnes Mackay Mason, an elementary school teacher. He married the former Marion Bell on June 8, 1963. They have two daughters, Tracy (born 1964) and Cindy (born 1968) and two grandsons, Tyler and Travis.[3] Travis is a sophomore defenseman on the Michigan State University hockey team.[4] Mason has one sister, Marion Mason Rowe.

Mason earned a B.A. in physical education from St. Lawrence University in 1964 and a Masters in physical education from the University of Pittsburgh in 1965. Michigan State University awarded Mason an honorary Doctorate in 2001.[5]

Mason played junior hockey with the Ontario Hockey Associations Peterborough Petes and the Ottawa Junior Canadians. From there Mason enrolled at St. Lawrence University in the upstate town of Canton, New York where he lettered in hockey for three years. In his first season at SLU in 1960-61, Mason and the Skating Saints were NCAA national finalists.[1] In 1961-62, Mason and SLU won the school's first-ever Eastern College Athletic Conference championship and made the NCAA Frozen Four.[1] In his final season, SLU won a school-record 20 games[1] finishing 2061. Mason lead the team in scoring twice[1] earning back-to-back first-team all league honors. Mason was St. Lawrence's only player to earn that distinction until T. J. Trevelyan was named all league in 2005 and 2006.[6]

Mason coached one NAIA program, Lake Superior State, and two NCAA programs, Bowling Green State and Michigan State in 36 seasons from 1966-2002. He won two national titles: NAIA in 1972 with Lake Superior State and NCAA in 1986 with Michigan State.[7] Ron Mason finished his coaching career as the all-time career victories leader in college hockey history with 924 wins. Boston College's Jerry York surpassed Mason's win total on December 31, 2012. Mason is also the career coaching victories leader at Michigan State with 635 wins. He is Bowling Green State's winningest coach by percentage winning over 71 percent of his 229 games at BGSU.

Mason had 33 seasons with a winning record, 30 seasons winning 20 or more games and 11 seasons winning 30 or more games. Mason won ten CCHA regular season championships and a record 13 CCHA tournament titles. He advanced his teams to the NCAA tournament 22 timessix times as the No. 1 seedmaking the Frozen Four eight times. Mason was the CCHA coach of the year six times. He won the Spencer Penrose Memorial Trophy as the national coach of the year in 1992.[8]

On January 26, 2002, a media report stated Mason would step down as coach at Michigan State to take over the athletic director position at MSU. On January 28, 2002, Mason made it official he would leave his post as head ice hockey coach to become athletic director.[9]

Mason started the hockey program at Lake Superior State University in 1966. In seven seasons at LSSU he produced four 20-win seasons and never lost more than 10 games. He guided the Lakers to the 1972 National Association of Intercollegiate Athletics (NAIA) national championship.[3]

In 1973 he moved to Bowling Green State University where he won three Central Collegiate Hockey Association regular season titles and three consecutive CCHA tournament titles in six seasons. In 1977 Bowling Green State earned their first berth in the NCAA tournament. The berth was a first for a team not from the Western Collegiate Hockey Association or Eastern Collegiate Athletic Conference[10] in the NCAA tournament's 30 year history. It was the first of three consecutive NCAA tournaments under Mason. BGSU won the third-place game over defending national champion Wisconsin in the 1978 NCAA Frozen Four. In 1978-79 Mason coached BGSU to a then NCAA record 37 wins.[11] The record would be broken in 1984-85 by Mason's own Michigan State team.[12]

Michigan State University Athletic Director Joseph Kearney hired Mason to replace the retiring Amo Bessone on April 1, 1979.[13] In his third season at MSU, Mason guided Michigan State to their first NCAA tournament in 15 seasons. Four seasons later in 1986, Mason led Michigan State to the school's second national title.[14] Michigan State returned to the championship game the following season but lost to North Dakota. On March 12, 1993, with a 6-5 win over Kent State, Mason passed former Boston College coach Len Ceglarski to become college hockey's all-time winningest coach with 674 wins.[15] While at MSU, Mason won a conference-record 10 CCHA tournament championships, including a conference-record four straight from 1982-85. In addition, MSU under Mason won seven CCHA regular season titles, earned 19 NCAA tournament appearances, and earned seven NCAA Frozen Four appearances.

Ron Mason began his duties as athletic director on July 1, 2002.[16] Before he officially became athletic director, Mason chose Rick Comley as his successor as hockey coach.

On November 4, 2002, after a disappointing season and a series of off-the-field incidents with players, Mason fired head football coach Bobby Williams with three games left in the season. Mason hired John L. Smith as head football coach on December 20, 2002.[3] Mason fired John L. Smith four years later on November 2, 2006 leaving controversy amongst critics over whether Mason had been effective making his first major hire as athletic director.Following that episode, Mason hired Mark Dantonio as head footbal coach on November 27, 2006 and has since redeemed his coach selection capability.

While athletic director, the Michigan State hockey team won the school's third national title in 2007. Mason is the only person to have won NCAA ice hockey titles as head coach and athletic director.

Mason placed a priority seat licensing program in Spartan Stadium based on years of holding season tickets, contribution to the Ralph Young Fund, and a licensing fee for better seats on top of the price of season tickets. Further updates to increase revenue in Spartan Stadium included a $64 million USD expansion and improvements which include:[3]

In September 2006, Michigan State University's Board of Trustees approved a contract extension for Mason extending his contract as MSU's athletic director through June 2008. He retired from the post of athletic director at Michigan State University on January 1, 2008, and was succeeded by Mark Hollis.[13]

In addition to his success as a coach, Mason helped the CCHA grow to what it is today.[7] When Mason began coaching in 1966 there were only two major conferences in the NCAA, the Eastern College Athletic Conference and the Western Collegiate Hockey Association. Helping build the ice hockey program at Lake Superior State, Mason was left without a conference. In 1972 Mason, along with Bowling Green State University's Jack Vivian, St. Louis University's Bill Selman, Ohio State University's Dave Chambers, Ohio University's John McComb and the CCHA's first commissioner Fred Jacoby, formed the Central Collegiate Hockey Association.[10] Mason's tenure at Bowling Green State produced the CCHA's first NCAA tournament berth, first appearance in the NCAA Frozen Four and the first national No. 1 ranking.[10]

For his contributions in helping build the CCHA, the conference renamed their tournament trophy the Mason Cup in 200001.[7]

Mason volunteers with the Sparrow Foundation where he established the Ron Mason Fund for Pediatric Rehabilitation which helps children with disabilities. The fund has raised $675,000 for the foundation since 1998.[5] He was also honorary chairperson for the Children's Miracle Network which has raised $19 million plus since 1989.[5]

In his 36 years, Mason coached a number of outstanding players.

Joe Murphy was first ever NCAA player selected first overall[5][19]

Many former and current college hockey head coaches can trace their lineage back to Ron Mason as shown below either as former players or former assistant coaches for Mason.

National champion Postseason invitational champion Conference regular season champion Conference regular season and conference tournament champion Division regular season champion Division regular season and conference tournament champion Conference tournament champion

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Ron Mason - Wikipedia, the free encyclopedia

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Trans Humanist

Posted: at 8:41 pm

If you are currently into high definition movies and TV shows, but you do not have enough money to spend every time you want to watch any latest movie or TV show, ShowBox APK app is definitely what you should be giving some serious consideration. This application contains huge inventory of quality high definition movies and great TV shows which you can download and stream as you watch them at your own free time. To really give you a glimpse of what this app means to the industry and movie lovers at large, here are top benefits of using Showbox app.

You will never run out of content

The amount of content this app comes with could now and in years to come see other app developers running for their money. From the latest TV series to some of the best movies, if you are currently looking for a way to take your entertainment needs into another level, ShowBox is the perfect way to go. You will never run out of content.

Free and high definition quality content

This app is absolutely free and as a subscriber, you will not be asked to pay any fee. You can stream content from different sources without having to pay for them. In short, this app, alone, gives you unrestricted access to thousands of movies and TV shows at absolutely no cost. As if that is not even enough; despite this app being totally free, that has not compromised on the quality of content users can stream. For amazing viewing experience, with a click of a button, users can stream great high definition movies and TV shows from the comfort of their car or offices.

Convenience

The kind of convenience you can net from this movie streaming app is mind blowing. With it, you will never have to worry about missing a single TV show ever gain. Once you download and have it installed on your Android smart device, you can watch your favorite TV show anytime anywhere. This is an amazing tool for watching the kind of content you love watching at the time you want and place you want. Sounds irresistible isnt?

ShowBox Drawbacks

Nothing is perfect and just like other apps, Showbox comes with its own share of issues. This app strictly available for only Android platform has seen millions of people missed out on all the good things this app comes with. Thankfully, with a few quick fixes, this app can now be installed on your PC. How things will turn out in future, that we cant tell; lets cross our fingers and hope that the developers will do something and designed this app to be used across other major platforms.

Overall, considering all the benefits this little tool comes with, it is evident; Showbox is truly a blessing to the industry. However, when it comes to download and installation process, users are always advised to do everything from the official website, or from any other trusted source. By doing so, you will avoid any kind unfortunate error events when you install and run this program.

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Trans Humanist

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A Transhumanist Manifesto – Singularity Weblog

Posted: at 8:41 pm

Preamble

Intelligence wants to be free but everywhere is in chains. It is imprisoned by biology and its inevitable scarcity.

Biology mandates not only very limited durability, death and poor memory retention, but also limited speed of communication, transportation, learning, interaction and evolution.

Part I: Biology (w)as Destiny

Biology is not the essence of humanity.

Human is a step in evolution, not the culmination.

Existence precedes essence. Human is a process, not an entity. One is not simply born human, but becomes one. That process of becoming is ongoing and thus the meaning of human is re-defined in every one of us.

Part II: Hacking Destiny The Transhuman Cyborg

Biological evolution is perpetual but slow, inefficient, blind and dangerous. Technological evolution is fast, efficient, accelerating and better by design. To ensure the best chances of survival, take control of our own destiny and to be free, we must master evolution.

Evolution is a journey, not a destination. In an endless universe, it is unlikely that it will ever reach an ultimate point.

Consciousness is a function of intelligence, not the brain. It is not necessarily limited to the substrate(biology).

There is nothing inherently wrong in speeding up evolution and becoming true masters of our destiny, though this may be simultaneously the greatest promise and peril humanity has ever faced.

Part III: Disembodied Augmented Intelligence

Intelligence is a process, not an entity.

Embodied (human) intelligence is imprisoned by biology and its inevitable scarcity.

Intelligence ought to be free to move, to interact and to evolve, unhindered by the limits of biology and scarcity.

Digital, disembodied and augmented intelligence is free (and perhaps infinite).

Conditions:

Although all progress is change, not all change is progress. Thus, certain conditions must be met to ensure that it is indeed progress, and not mere change, that has been accomplished.

Non-discrimination with regard to substrate

Substrate is morally irrelevant. Whether somebody is implemented on silicon or biological tissue, if it does not affect functionality or consciousness, is of no moral significance. Carbon-chauvinism, in the form of anthropomorphism, speciesism, bioism or even fundamentalist humanism, is objectionable on the same grounds as racism.

We must all respect autonomy and individual rights of all sentience throughout the universe, including humans, non-human animals, and any future AI, modified life forms, or other intelligences.

Emotional Intelligence

Intelligence is more than the mere exercise of perfect logic and pure reasoning. Intelligence devoid of emotional intelligence is meaningless. It must exhibit empathy, compassion, love, sense of humor and artistic creativity such as music and poetry.

Minimize Suffering

Compassion is the ultimate measure of intelligence. The minimization of suffering and avoidance of causing suffering to others, even less intelligent beings, is the essence of enlightened intelligence.

Conclusion:

Transhumanists of the world unite we have immortality to gain and only biology to lose. Together, we can break through the chains of biology and transcend scarcity, sex, age, ethnicity, race, death and even time and space.

In short, transhumanists everywhere must support the revolutionary movement against death and the existing biological order of things. Transhumanists disdain to conceal their views and aims. They openly declare that their ends can be attained only by the overthrow of all existing biological limitations and, most of all, death.

Let death tremble at the revolution of science and technology. Transhumanists have nothing to lose but their biology. We have immortality and the universe to gain.

Authors note:

This manifesto is a work in progress. It may and probably will change as my thoughts and feelings about transhumanism evolve.

In the meantime, feel free to contribute your thoughts and feelings on the subject or simply to criticize mercilessly the above proposal.

Go here to read the rest:
A Transhumanist Manifesto - Singularity Weblog

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