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Category Archives: Transhuman News
Genetic test to predict opioid risk lacks proof, experts say – Philly.com
Posted: February 6, 2017 at 2:46 pm
It sounds like a godsend for America's opioid epidemic: genetic tests that can predict how a patient will respond to narcotic painkillers, as well as an individual's risk of misuse, addiction, and potentially deadly side effects.
Proove Biosciences of Irvine, Calif., claims its "opioid response" and "opioid risk" tests are the only precision medicine tools on the market to do all that, giving doctors information "to guide opioid selection and dosage decisions as well as treat side effects."
But while the concept is captivating, addiction researchers say it is not yet possible to use genetic variation to gauge the risk of drug abuse. And ECRI Institute, a Plymouth Meeting nonprofit center that evaluates medical technology, says Proove has not published independently reviewed studies to support its claims.
"We cant say it doesnt work. All we can say is, theres no evidence it does," said ECRI research analyst Jeff Oristaglio.
In an interview, Proove CEO Brian Meshkin defended his five-year-old products, which he said retail for $1,000 a test and were used by about 400 doctors last year in treating 50,000 patients. He said he expects scientific journals to publish results from studies "within the next six months." Three clinical trials of the opioid response test are ongoing.
Consumers may assume that such high-tech genetic tests have to demonstrate safety and effectiveness to win regulatory approval, but they do not. Even though these complex diagnostics use the latest gene-sequencing and data-crunching techniques, they can come to market under 1988 federal regulations designed to ensure the quality of clinical laboratories.
Two years ago, the U.S. Food and Drug Administration proposed a new framework for overseeing "lab-developed tests" that would take into account their complexity and riskiness, because inaccurate or false results can harm patients. But the agency withdrew the controversial proposal after the November election, saying it needed "to continue to work with stakeholders, our new administration, and Congress."
Proove is one of many companies in the fast-growing genetic-susceptibility testing market, a multi-billion industry built on trying to foresee and thus, forestall disease, disability, and death.
Opioid-related deaths have become an urgent public-health crisis. Every day, on average, 3,900 people start abusing prescription painkillers, 580 graduate to cheaper heroin, and 78 die of a narcotic overdose, according to federal data.
In theory, genetics provides an opportunity to reduce this toll. Researchers have linked a predisposition to opioid dependency to gene variants involved in the brain's signaling of reward and pleasure. Addictive behavior, particularly alcohol abuse, is known to run in families.
But addiction experts say risky behavior involves the largely unpredictable interplay of environmental, cultural, and biological factors.
"It is hard to conceive of a genetic test or a genetic score that would be valuable as a predictor of opiate abuse or addiction in general," said Michael Vanyukov, a University of Pittsburgh professor of pharmaceutical sciences, psychiatry and human genetics.
Vanyukov, who wasn't familiar with Proove's products, said heredity plays a relatively small role in determining variation in addiction risk, while choices and perceptions can play a big role. "If the individual is informed of, say, a 'low' risk score, this very piece of information will change the risk. The error of a genetic score is likely to be great, and reliance on it in practice may be dangerous."
Psychiatrist Charles OBrien, founding director of the University of Pennsylvania's Center for Studies of Addiction, was also unfamiliar with Proove's test, but echoed that sentiment: "I could not in good conscience recommend that someone spend money on these tests."
O'Brien's own center recently identified gene variants associated with response to naltrexone, a drug that blocks the intoxicating effects of alcohol. But when the center studied alcoholics on naltrexone, strong and weak responders had the same number of heavy drinking days.
"We were very disappointed because we're all looking for precision medicine," O'Brien said.
Proove's tests analyze DNA from a cheek swab. The opioid risk test gives the patient a score low, moderate, or high risk of opioid abuse that is based on detecting variants in 12 genes, combined with clinical information such as a history of depression. The company's website claims the algorithm is 93 percent accurate.
But when ECRI scientists looked to validate that claim, all they could find were brief summaries of two studies that the company presented at medical conferences. One studyof 290 patients compared the Proove risk test with the "opioid risk tool," a standard, one-minute screening questionnaire that doctors use to ask chronic pain patients about risk factors such as a history of mental illness or substance abuse.
"We cannot determine ... whether the test performs better or worse than the opioid risk tool in predicting opioid misuse," ECRI concluded.
Insurance plans either consider Proove's tests unnecessary or have no specific policies, ECRI found, although Meshkin said insurers are covering the cost "on a case-by-case basis."
"At some point, you've got to stop and produce the evidence if you want people to pay," said Diane Robertson, director of ECRI's health technology assessment service. "Why would anyone want to use something if there is no evidence that it has benefit?"
Published: February 6, 2017 10:09 AM EST The Philadelphia Inquirer
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Gene that protects against inflammatory bowel disease identified – Science Daily
Posted: at 2:46 pm
UT Southwestern Medical Center researchers have identified a gene that protects the gut from inflammatory bowel disease (IBD).
The mouse study found a mutation in the Gatm gene and used CRISPR/Cas9 gene-editing technology to confirm this link. The Gatm gene is required for the rapid replenishment of the intestinal mucosal barrier that guards the intestinal wall against inflammation caused by bacteria in the digestive tract, researchers determined.
"The Gatm gene is needed for the synthesis of creatine, a substance made in the liver that travels to the barrier cells and allows them to utilize energy in an efficient manner," said Nobel Laureate Dr. Bruce Beutler, Director of UT Southwestern's Center for the Genetics of Host Defense and senior author of the study, which was published this week in the Proceedings of the National Academy of Sciences.
IBD involves a chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn's disease, according to the Centers for Disease Control and Prevention. Although ulcerative colitis is limited to the large intestine, Crohn's disease can affect any part of the digestive tract.
Under normal conditions, the body maintains a balance between the intestinal tract's ability to respond to disease-causing bacteria and tolerance of normal commensal "good" bacteria that aid digestion.
To understand the mucosal barrier, researchers said, the intestines can be compared to a battlefield during a lull in fighting. Normally, mucus lines the intestines and forms a barrier that is similar to a demilitarized zone. That mucus barrier protects the intestinal walls from both the disease-causing and beneficial bacteria. However, if the bacteria somehow get through that mucus layer and reach the intestinal walls, inflammation is the result, explained lead author Dr. Emre Turer, Assistant Professor of Internal Medicine and in the Center for the Genetics of Host Defense.
In their experiments, mice with two copies of the recessive Gatm mutation showed symptoms similar to people with IBD: diarrhea, weight loss, and the death of cells lining the intestine. Those symptoms improved when the mice received creatine in their drinking water, the researchers said. The study indicates that creatine is necessary for providing the energy needed for the rapid replenishment of the mucosal barrier.
"Mutations in this gene and others needed for mobilization of energy in cells may account for some cases of IBD in humans," said Dr. Beutler, also Professor of Immunology.
The study identified several other potential colitis genes, he added, and this particular one's effect on the barrier cells' energy requirements suggests a new category of mutations with the potential to cause IBD. Each gene was found by random germline mutagenesis, meaning mutations were created in order to study resulting traits.
"IBD is a chronic, relapsing, remitting disease in which evidence of healing in the lining of the digestive tract is critical for long-term remission. Current therapy tends to focus on reducing the inflammatory response," Dr. Beutler said. "However, proper healing of the mucosal layer and cells that line the digestive tract is essential to long-term remission. This study indicates that healing requires effective energy metabolism."
Further, he added, "knowing these genes may help us to understand how IBD occurs in humans, and how to treat it." Earlier in his career, Dr. Beutler discovered an important family of receptors that allow mammals to sense infections when they occur, triggering a powerful inflammatory response. For that work he received the 2011 Nobel Prize in Physiology or Medicine. He now runs one of the world's largest mouse mutagenesis and forward genetics programs.
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Letter to the Editor: Political dishonesty – The Lake Country Echo
Posted: at 2:46 pm
They promote speculative conspiracies to somehow make people think they are smarter than everyone. And they are going to show us by resorting to violent protests, threats and obstruction of the political process set forth by the Founding Fathers.
Grow up. Our government's first loyalty is to its citizens and the national interests and the preservation of our culture and our civil institutions. The people who elected Donald Trump top worries are terrorism, national security, the economy and the ballooning national debt. We voted for Trump because he isn't afraid to say the things we also say, even if those things are deemed racist, sexist, xenophobic or politically incorrect.
People are fed up, people are hurting, they are very distressed about the fact that their kids don't have a future. America is tired of the 20 percent professional class, which encompasses the vast majority of our media figures, economists, Washington officials and Democratic powerbrokers destroying what built this country - jobs and American ingenuity.
The other 80 percent, the working class, is tired of the 30 years of Washington's free-market consensus, which did nothing more than weaken our economic future. We are the people who elected Donald Trump.
Pastor Dale Anderson,
Backus
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CBS’s ‘Training Day’ Features a Politically Incorrect Cop Liberals Will Hate – NewsBusters (blog)
Posted: at 2:46 pm
NewsBusters (blog) | CBS's 'Training Day' Features a Politically Incorrect Cop Liberals Will Hate NewsBusters (blog) CBS's new police drama, Training Day, debuted Thursday night with the episode titled Apocalypse Now. Based on the 2001 movie with the same name and using the movie's director (Antoine Fuqua) as a producer, the show diverges with its portrayal of a ... |
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Pakistan’s Censorship Takes a Dangerous Turn – The Diplomat
Posted: at 2:45 pm
Renowned Pakistani poet, social activist and academic Salman Haider was abducted on January 6 from Islamabad Highway while he was on his way back home. His wife received a text from his own number, telling her to pick the car from a place few hundred meters away from their house. As the news about his abduction emerged in the mainstream media, the families of two other bloggers, Aasim Saeed and Ahmed Waqas Goraya, reportedto the police that they had been missing since January 4. Two other activists, Ahmed Raza Naseer and Samar Abbas, also went missing in the following days. All of them are well-known for holding a progressive worldview, often critical of the militarys policies.
After weeks of speculation and widespread protests across the country, fourof them returned to their families on January 28. Two of them have since left the country after an active media campaign framing them as blasphemers threatened their lives. The other two, although still in Pakistan, have relocated along with their families, uncertain about their future.
While several quarters suspect military spy agencies of being behind the abductions, the director general of the militarys Inter Services Public Relations (ISPR), Major General Asif Ghafoor, in his first press conference, denied the armys involvement. Still, abold editorial appearing in Dawn newspaper on January 11 read, The sanitized language missing persons, the disappeared, etc. cannot hide an ugly truth: the state of Pakistan continues to be suspected of involvement in the disappearance and illegal detentions of a range of private citizens.
Dawns editorial predicted that a dark new chapter in the states murky, illegal war against civil society appears to have been opened.
After protests against the disappearances erupted, a popular Twitter and Facebook hashtag #WhoAreTheyDefending accused the protesters of supporting blasphemers, with many tweets calling for their deaths. TV anchor and televangelist Aamir Liaquat Hussain launched an attack against leading journalists like Owais Tohid, media outlets like Jang and Dawn group, as well as several members of the civil society, accusing them of committing treason and blasphemy. In doing so, Hussain who hosts a controversial talk show in a recently-launched TV channel repeatedlydefied a banon such accusations laid down bythe Pakistan Electronic Media Regulatory Authority(PEMRA), which called Liaquats commentshate speech.
Renowned activist and analysts Marvi Sirmed, who herself has come under personal attacks from Aamir Liaquat Hussain, believes there is no way to know if he is parroting someones line. However, looking at who else is taking the position that Aamir Liaquat is taking, it becomes clearer which unseen power wants that line to be propagated, she says.
In October last year, Dawn newspaper staffer Cyril Almeida reported the details of an off-camera meeting where the civilian leadership confronted the then-director general of Inter-Services Intelligence(ISI), Lt. General Rizwan Akhtar, about not allowing action against banned outfits in Punjab. Almeidas story drew a strong backlash from the government, andhis name was put on the Exit Control List only to be removed a few days later after a strong response from the English press and overall media platforms.
Daily The Nation, in aneditorial following the ban on Cyril Almeida, wrote, how dare the government and military top brass lecture the press on how to do their job. How dare they treat a feted reporter like a criminal. And how dare they imply that they have either the right or the ability or the monopoly to declare what Pakistans national interest is.
While the media attempt to push back, the state-sponsored censorship seems to be expanding from topics like Balochistan to the China-Pakistan Economic Corridor (CPEC); from mainstream to social media. Marvi Sirmed has observed the same phenomenon. I havent received any direct censorship directions from anywhere ever. Its just that they show their displeasure through hundreds of anonymous Twitter accounts, she says.
Sirmed, who writes a weekly column for Pakistan Today, recounts how her voice was censored: Recently, my regular column in The Nation has been stopped abruptly in the wake of pressure from some known unknowns.
The Nation became a target of social media abuse under the hashtag #ShameOnTheNation after publishing some op-eds criticizing the states policies. After a barrage of abuse and threats online, the publication was forced to remove some of the op-eds from its website.
After The Newsrecently broke the news that 90 acres of land had been allotted to the former chief of army staff, General Raheel Sharif, an organized campaign, both online and offline, called Jang Group treasonous and a blasphemer. Overnight, banners calling for the death of Najam Sethi a senior journalist and analyst associated with Jang Group appeared in front of the Karachi Press Club.
Shad Khan, a U.K.-based Pakistani journalist, was recently removed from the country while he was filming for a documentary on the effects of investment brought by CPEC on the people of Gwadar.
I was granted permission by the Gwadar Port Authority to shoot around the area, Khan says.
Known for The Secret Drone War, which won him an Amnesty Award, Khan was provided with a security official in Gwadar. I filmed with Pakistan Navy for a day after they verified all of the documentation provided by me, he says. However, on the fifth day of shooting, I started receiving visits from officials in civilian clothes who asked for my identity card and I was interrogated by an army major.
Khan was asked to leave Gwadar without his equipment and the intelligence officials accompanying escorted him to a plane for the U.K.
Khan explains the apparent reason for his removal. I had to cover a rally of Sardar Akhtar Mengal, the head of Balochistan National Party, when they came to me and asked me to not cover the rally at all, Khan recalls. Upon my refusal to comply with their demand, they requested to cover the rally positively, which, as a journalist, is not a good practice.
Im a Pakistani citizen but not sure if I was just removed or deported. Im not sure if I still hold the Pakistani nationality or not. Pakistani High Commission in the U.K. hasnt returned my queries, he laments.
A similar incident happened with two New York City-based filmmakers, Rehana Esmail and Sina Zekavat, who have been working on a documentary called Boats Above My House for the past 18 months. The film is about a landslide in the northern areas of Pakistan and the chain of environmental, social, political, and economic events that followed. We focus on a group of people in Attabad village who are not formally recognized as citizens and are attempting to build their lives back after they lost their homes after this landslide, Zekavat says.
Their film received an on-site stop order on November 3, 2016from the Pakistani security agencies. Our line producer and DP (all locals) were forced to undergo a prolonged and unclear investigation process, Zekavat says, adding, all of our gear (including rental equipment and personal cell phones) and footage is being held for a forensic investigation and weve been informed that there are possibilities of serious charges against our fellow crew members.
One of the people they were filming with was Naz, who is the sister of the Baba Jan a left-wing activist and politician currently imprisoned for life. Naz is partially involved in her brothers release from prison as well the general human rights situation for people of Gilgit-Baltistan, Sina Zekavat says, adding, however, the footage that we got up until the stop, mainly consisted of Naz and her family cooking and eating together and doing very ordinary things.
The line of questioning by the investigators focused on filming Baba Jans house, which the co-directors insist wasnt the highlight of the documentary. Human rights activist and lawyer Asma Jahangir has decided to take up their case in the court.
In another sign of a growing crackdown, the Pakistan Telecommunication Authority (PTA) recently banned Khabaristan Times, a satire news website famous for taking on politicians, the military, and religious extremists.
Khabaristan Timeseditor Kunwar Khuldune Shahid considers the ban a continuation of the states crackdown on dissent in online spaces. Our content was published without any bylines, and the author only revealed their name to their audience if they chose to. Article 23 of the cybercrime law itself outlaws spoof and parody, and hence could be triggered to ban the satirical publication, he says.
Khuldune adds: Whether it was to target satire or anonymity, it is evident that secular and liberal voices are being targeted. For many jihadist groups are open to express themselves many do it anonymously as well.
Islamabad-based journalist Taha Siddiqui believes the attempts by the state to coerce journalists into toeing their narrative line are increasing. State has financially squeezed news networks if they tried to challenge the state narrative or openly report on taboo topics like Pakistani military affairs independently, since manages stories on such topics.
Siddiqui predicts tougher days for dissenting voices in Pakistan. The worst part is that journalists and activists have no idea what the red line is anymore and the state has started to react even more violently when it wants to clamp down on those who are vocal about critically evaluating sociopolitical issues in Pakistan, he asserts.
Kunwar Khuldune Shahid, who is a keen observer of current affairs himself, agrees.
This targeting of secular pages and websites could be a way to appease the Islamist sections at a time when a crackdown against jihadist groups and leaders has become inevitable owing to international pressure.
Hafiz Saeed being under house arrest, and members of LeT and JuD being put under the ECL [exit control list], highlights this. Maybe the states action against liberal voices, and the fact that it preceded the crackdown, was designed to forestall the Islamist backlash, he concludes.
Umer Ali is a freelance journalist based in Pakistan. He reports on human rights issues, social problems and more. He can be reached on Twitter at @iamumer1.
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Arizona Bill Would Stop Censorship Of High-School Newspapers – KJZZ
Posted: at 2:45 pm
Arizona Bill Would Stop Censorship Of High-School Newspapers KJZZ A Supreme Court decision has ruled student newspapers don't have the same constitutional rights as other publications. But an Arizona state senator saw that as having a chilling effect and introduced a bill to stop school administrators from censoring ... |
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Australia’s chief scientist: Trump’s EPA changes akin to Stalin’s censorship of science – TheBlaze.com
Posted: at 2:45 pm
Australias top governmentscientist is likeningPresident Donald Trumps changes at the U.S. Environmental Protection Agency to scientific censorship under Soviet Union dictator Joseph Stalin.
Chief Scientist Alan Finkel, speaking during a roundtable discussion in Australias capital city ofCanberra, said Monday that science is literally under attack in the United States, according to the Guardian:
TheTrump administrationhas mandated that scientific data published by the United States Environmental Protection Agency from last week going forward has to undergo review by political appointees before that data can be published on the EPA website or elsewhere.
It defies logic. It will almost certainly cause long-term harm. Its reminiscent of the censorship exerted by political officers in the old Soviet Union.
Every military commander there had a political officer second-guessing his decisions.
Finkel was referring to a decisionby the Trump administration last month for political appointees toreview all the scientific data foundby scientists at the EPA before it can be cleared for publication.Doug Ericksen, communications director for Trumps EPA transition team, said that the review also applies to information on the agencys website and social media accounts.
And in January, EPA staffers said that the Trump White House ordered the agencyto remove its webpage on climate change a move that ruffled the feathers of many environmentalists.
If the website goes dark, years of work we have done on climate change will disappear, one unnamed EPA staffer told Reuters last month, adding that some employees were working to preserve the data stored there.
Were taking a look at everything on a case-by-case basis, including the web page and whether climate stuff will be taken down, Ericksentold the Associated Press. Obviously with a new administration coming in, the transition time, well be taking a look at the web pages and the Facebook pages and everything else involved here at EPA.
Climate Central reported last weekthat the EPA has, in fact, started removing Obama-era information from the government website. Theyre mostly scrubbing it of anything that has a hint of Obama, Gretchen Goldman,research director for the Center for Science and Democracy at the Union of Concerned Scientists, said.
The administration, however, has downplayed the ordeal. White Housepress secretary Sean Spicer, who first denied Trumpdirectly orderedthe EPAs data scrub, said in January that the communications clampdown on scientific datawas not out of the ordinary, telling reporters, I dont think its any surprise that when theres an administration turnover, that were going to review the policy.
ButGeorge Gray, who was theassistant administrator for the EPAs Office of Research and Development under former PresidentGeorge W. Bush, told the Guardian that scientific studies are typically reviewed at lower levelsand rarely by political appointees.
Scientific studies would be reviewed at the level of a branch or a division or laboratory, he said. Occasionally, things that were known to be controversial would come up to me as assistant administrator and I was a political appointee. Nothing in my experience would go further than that.
Finkel, for his part, sees the White Houses decision as akin to Stalins efforts to censor science.
Soviet agricultural science was held back for decades because of the ideology of Trofim Lysenko, who was a proponent of Lamarckism, he said. Stalin loved Lysenkos conflation of science and Soviet philosophy and used his limitless power to ensure that Lysenkos unscientific ideas prevailed.
As the Smithsonian Magazine outlined, Lysenko was Stalins director of biology and he led a group of animal and plant breeders who rejected the science of genetics. He worked to discredit the genetic discoveries of Gregor Mendel and Thomas Hunt Morgan, attacking them for being foreigners with idealistic ideas that were the product of bourgeois capitalism.
Lysenko argued that he could quickly force plants and animals and even the Soviet people into forms that could meet practical needs and that those characteristic changes could be passed on to their offspring a debunked theory known as Lamarckism.
One of Lysenkosmost infamous claims was that he changed a species of spring wheat into winter wheat after just a few years. That was, of course, impossible, but it fed into Stalins mantra that the Soviet government could create the perfect utopia.
So while Western scientists embraced evolution and genetics, Russian scientists who thought the same were sent to the gulag. Western crops flourished. Russian crops failed, Finkel said. Today, the catch-cry of scientists must be frank and fearless advice, no matter the opinion of political commissars stationed at the U.S. EPA.
Last week, the Senate Committee on Environment and Public Works suspended rules to approve Oklahoma Attorney General Scott Pruitt to lead the EPA without any Democrats present. The Democrats boycotted Pruitts hearing last Wednesday, citing concerns over his rejection of climate change science.
A date for the Trump appointees full Senate vote has not yet been set, but given Republicans lead the Senate, his nominationis expected to be approved.
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Australia's chief scientist: Trump's EPA changes akin to Stalin's censorship of science - TheBlaze.com
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Censorship or parental control? Va. lawmakers divided on bill – WTOP
Posted: at 2:45 pm
The bill would require schools to notify parents of any potentially sexually explicit classroom material and require that schools offer an alternative for the students of any parents who opt out. (Thinkstock)
WASHINGTON Virginias House of Delegates could take a final vote Monday on a bill that would require schools to notify parents of any potentially sexually explicit classroom material and require that schools offer an alternative for the students of any parents who opt out.
Opponents of the bill said it amounts to censorship in schools. Supporters said it is simply a requirement to keep parents informed and in control.
This does not prohibit any teacher from assigning any type of material they deem necessary or appropriate. It does not ban books. It does not ban any materials that teachers or school systems would like to have on their reading list and the like. It doesnt do that, the bills patron Del. Steve Landes, R-Augusta, said Friday.
This legitimately addresses a legitimate concern that parents raised, he said.
Del. Dave Albo, R-Springfield, described the bill as a compromise that strikes a fair balance.
I think that 99.99999 percent of the parents in Virginia would like to know if someone assigned a book that has scenes about sexual abuse of a child and infected sexual battery, Albo said.
Del. Alfonso Lopez, D-Arlington, said that even though this years bill set for a final vote is narrower than the bill that was vetoed by Gov. Terry McAuliffelast year, there would still be significant unintended consequences and problems.
More than likely, a teacher will not be able to do two entire lesson plans for the same class, sometimes on a very quick turnaround, after an objection from just one parent. This makes it much less likely that theyd be willing to even attempt to use anything that might be considered objectionable in their lessons, Lopez said.
He said it would be a form of censorship that could limit all kinds of classic art and literature.
For a junior taking AP English and learning iambic pentameter, what is less objectionable literary work that is the equivalent to any of Shakespeares plays? Lopez said.
Most importantly, what is an equivalent work to Toni Morrisons Beloved, which teaches us in a very raw and unflinching manner and terms about the horrors of slavery? he added.
The bill was originally triggered by a Fairfax County mother who protested the use of Beloved in her sons class when he was a senior in high school.
Lopez and Del. Vivian Watts, D-Annandale, warned of a potential black eye for Virginias reputation if the bill passes, and it becomes widely reported or mentioned on late-night TV.
Lopez cited the widespread reaction to the recent move in Accomac, Virginia, to pull To Kill a Mockingbird and The Adventures of Huckleberry Finn following a parents complaint.
We will end up with excluding for all what might be objectionable to just a few, she added.
The bill advanced Friday on a voice vote to a final vote that is expected on Monday. The bill would then go to the state Senate.
Del. Nicholas Freitas, R-Culpeper, said this is simply a service for parents.
I dont care how many Pulitzer Prizes it has. If its sexually explicit material, that might be something as a parent that I want to be notified of, Freitas said.
Read the proposed bill on theVirginia General Assembly website.
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Censorship or parental control? Va. lawmakers divided on bill - WTOP
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A Pirate Podcast App Takes on Iran’s Hardline Censors – WIRED
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Slide: 1 / of 2. Caption: RadiTo
Slide: 2 / of 2. Caption: RadiTo
Reza Ghazinouri remembers the importance of pirate radio as a teenager growing up in in the city of Mashhad in northeast Iran. His father tuned in multiple times a day to the banned Farsi version of the BBC transmitted from neighboring countries, to hear the truth about Iranian political scandals like the impeachment of the countrys liberal minister of culture, and the shutdown of dozens of its newspapers. While Ghazinouri studied for his college entrance exams in 2003, hed listen to the US government-funded Radio Farda coverage of student protests against university privatization. I still remember those programs so clearly, Ghazinouri says, Every night Id imagine myself protesting like the students.
Today, Ghazinouri has found his own form of protest. Hes one of the creators of an app that aims to bring the same contraband audio to modern Iran in a revamped form: the pirate podcast. Today he and his fellow activists and coders at the Berkeley-based, Iran-focused app developer IranCubator will launch RadiTo, an audio app for Android uniquely suited to the conditions of the countrys internet. It navigates slow, expensive data connections, users who speak a variety of languages and dialects ignored by most podcast distributors, and trickiest of all, a draconian digital censorship regime. With RadiTo, the group hopes to evade that internet filtering and bring a rare stream of aural information about the outside world to the countrys burgeoning smartphone culture.
For now, the app works as a kind of digital radio tool, offering banned foreign channels like the BBC, Radio Farda, and Amsterdam-based Radio Zamaneh. But eventually RadiTo, whose name means Radio You in Farsi, plans to let anyone create their own podcast channel, serving as a kind of audio-only Iranian YouTube for illicit ideas and entertainment. This allows individuals to have a platform to broadcast whatever they want to broadcast, says Firuzeh Mahmoudi, one of IranCubators founders and the executive director of its creator United For Iran. Getting access to radio stations outside the country is imperative, and a platform where individuals can have channels to share information is critical.
Beyond mere news, RadiTo will offer audio channels devoted to other subjects forbidden in Iran. One show it plans to distribute, called Taboo, has in the last several months devoted episodes to censored topics like pre-marital sex, separatist groups, and the female orgasm. Another show will focus on Iranian mysticism, a controversial topic under Irans strict interpretation of Islam. Both shows are run by Iranians living in America; the subjects they cover, after all, are a form of thought crime in Iran. Irans digital censorship body, the Supreme Council for Cyberspace, has long blocked all internet content in the country that violates its tight restrictionseverything from political dissent against the countrys hardline regime to cultural content it considers anti-Islamic.
RadiTo has a few ideas about how to stay ahead of that filtering. It offers two ways to download RadiTo: both Google Play and trusted Telegram accounts, like the one run by pseudonymous Iranian activist and blogger Vahid Online. Iran doesnt currently block either method, Ghazinouri says, and since connections to Google Play are encrypted, the Iranian censors cant easily block downloads of RadiTo without blocking all connections to the Android app store that serves more than 70 percent of the countrys smartphone users. The server that hosts RadiTos content, Ghazinouri explains, is hosted on Amazon Web Services and encrypted, which similarly hides its data in a tough-to-block collection of other services. (The encrypted calling and texting app Signal recently used a similar tactic to circumvent blocking of the app in Egypt and the United Arab Emirates.)
Ghazinouri concedes that the government might still find a way to block the apps connections by, say, identifying the exact IP range of the apps Amazon servers, or using deep packet inspection to spot its data in transit. So the group also has a workaround in mind: In the case of a block, its ready to push an update to the app via both Google Play and Telegram that would embed a proxy function, routing its data over the Psiphon network, an anti-censorship tool created by the University of Torontos Citizen Lab, which bounces users connections through the computers of volunteers outside Iran. Individual Farsi audio apps from broadcasters like Radio Zamaneh do have their own Android apps, but probably arent as well prepared to play the cat-and-mouse game of censorship evasion, argues Ghazinouri. The Iranian government comes up with new censorship techniques all the time, says Ghazinouri. You always have to have a Plan B.
Iranians can already access some of these services piecemeal, through proxies and other workarounds. But RadiTo on top of censorship circumvention, RadiTo also has features that solve uniquely Iranian problems. Its interface offers not only Farsi and English, but four other Iranian minority languages: Balouchi, Iranian-dialect Turkish, Kurdish, and Arabic. And it allows users to download content and listen offline, a crucial setting in a country where a lack of infrastructure and intentional government throttling slows internet speeds to an expensive trickle. Theres no other Iranian app that offers all this, says Fereidoon Bashar, an internet activist and developer at the Toronto-based technology lab ASL-19, which is working with IranCubator on future apps for the same market. Its accommodating not just the user experience, but also the internet ecosystem that exists in Iran, the limited access to data.
RadiTo is only the first official launch for IranCubator. In the coming months, it hopes to launch a dozen apps, all tailored for Iranian users and the challenges of Irans cloistered internet. Later in February, for instance, IranCubator plans to release a tool called Hamdam, aimed at womens health education. Hamdam will include a period tracker, information about marriage rights and divorce, and advice about dealing with domestic violence.
IranCubator founder Mahmoudi says she hopes the groups human-rights focused apps can collectively ride the growing wave of mobile device adoption in Iran, where 40 million people already own smartphones, with a million more added every month. Iranians are tech-savvy and globally minded. They want to be in a county thats more democratic and worldly, says Mahmoudi. All the indicators are there. Technology is the right tool to engage people where they want to engage.
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A Pirate Podcast App Takes on Iran's Hardline Censors - WIRED
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Australia’s chief scientist tears Trump’s EPA mandate: ‘It’s reminiscent of the censorship exerted by political … – Yahoo News
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Yahoo News | Australia's chief scientist tears Trump's EPA mandate: 'It's reminiscent of the censorship exerted by political ... Yahoo News Washington's new UN envoy Nikki Haley is putting in motion a far-reaching review of UN peacekeeping that is likely to lead to closures and downsizing of missions, according to diplomats. Haley took up her post with a vow to overhaul the United Nations ... |
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