Category Archives: Transhuman News

(BPT) - Whitney was only 19 years old, home from college freshman year, when her mother noticed spots on her arms and elbows. As any parent would be, Whitneys mother was concerned and suggested her daughter see a dermatologist. That visit revealed her diagnosis of moderate-to-severe plaque psoriasis. Little did Whitney know, this would be a lifelong battle that would impact all aspects of her life.

Plaque psoriasis is a chronic autoimmune skin disease that speeds up the growth cycle of skin cells, causing patches of thick red skin and silvery scales affecting approximately 6 million Americans.1

When I was younger and my psoriasis was flaring, it was very embarrassing and shameful, Whitney said. People didnt understand that I was not contagious. I can remember being turned away by hair stylists who didnt want to cut my hair and being refused a pedicure. My friends and boyfriends didnt understand what was going on with me and I could feel them pulling away at times.

After talking with her doctor about her symptoms, she prescribed a biologic treatment called STELARA (ustekinumab).

I went through some very challenging times with my psoriasis symptoms. Starting treatment with STELARA helped me to take control of my disease and start to create new memories with my family and friends, said Whitney. With clearer skin, I was able to walk down the aisle in a strapless wedding dress, and it was amazing!

Eventually, Whitney would also be diagnosed with psoriatic arthritis, an inflammatory arthritis causing joint pain, stiffness and swelling that affects approximately 30 percent of people with psoriasis.2 STELARA (ustekinumab) also is approved to treat psoriatic arthritis and, over time, Whitneys joint pain and swelling have diminished significantly.

Visit http://www.STELARAINFO.com to learn more about STELARA

WHAT IS STELARA?

STELARA is a prescription medicine approved to treat adults 18 years and older with moderate or severe plaque psoriasis that involves large areas or many areas of their body, who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills).

STELARA is a prescription medicine approved to treat adults 18 years and older with active psoriatic arthritis, either alone or with methotrexate.

STELARA (ustekinumab) works by targeting an underlying cause of plaque psoriasis and psoriatic arthritis an overactive immune system. It blocks two proteins called IL-12 and IL-23 that may play a role in plaque psoriasis and psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

STELARA (ustekinumab) is a prescription medicine that affects your immune system. STELARA can increase your chance of having serious side effects including:

Serious Infections

STELARA may lower your ability to fight infections and may increase your risk of infections. While taking STELARA, some people have serious infections, which may require hospitalization, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses.

Your doctor should check you for TB before starting STELARA and watch you closely for signs and symptoms of TB during treatment with STELARA.

If your doctor feels that you are at risk for TB, you may be treated for TB before and during treatment with STELARA.

You should not start taking STELARA if you have any kind of infection unless your doctor says it is okay.

Before starting STELARA, tell your doctor if you:

think you have an infection or have symptoms of an infection such as:

After starting STELARA, call your doctor right away if you have any symptoms of an infection (see above).

STELARA can make you more likely to get infections or make an infection that you have worse. People who have a genetic problem where the body does not make any of the proteins interleukin 12 (IL-12) and interleukin 23 (IL-23) are at a higher risk for certain serious infections that can spread throughout the body and cause death. People who take STELARA may also be more likely to get these infections.

Cancers

STELARA may decrease the activity of your immune system and increase your risk for certain types of cancer. Tell your doctor if you have ever had any type of cancer. Some people who had risk factors for skin cancer developed certain types of skin cancers while receiving STELARA. Tell your doctor if you have any new skin growths.

Reversible posterior leukoencephalopathy syndrome (RPLS)

RPLS is a rare condition that affects the brain and can cause death. The cause of RPLS is not known. If RPLS is found early and treated, most people recover. Tell your doctor right away if you have any new or worsening medical problems including: headache, seizures, confusion, and vision problems.

Serious Allergic Reactions

Serious allergic reactions can occur. Stop using STELARA and get medical help right away if you have any symptoms such as: feeling faint, swelling of your face, eyelids, tongue, or throat, chest tightness, or skin rash.

Before receiving STELARA, tell your doctor if you:

have any of the conditions or symptoms listed above for serious infections, cancers, or RPLS.

ever had an allergic reaction to STELARA or any of its ingredients. Ask your doctor if you are not sure.

are allergic to latex. The needle cover on the prefilled syringe contains latex.

have recently received or are scheduled to receive an immunization (vaccine). People who take STELARA should not receive live vaccines. Tell your doctor if anyone in your house needs a vaccine. The viruses used in some types of vaccines can spread to people with a weakened immune system, and can cause serious problems. You should not receive the BCG vaccine during the one year before taking STELARA or one year after you stop taking STELARA.

have any new or changing lesions within psoriasis areas or on normal skin.

are receiving or have received allergy shots, especially for serious allergic reactions.

receive or have received phototherapy for your psoriasis.

have any other medical conditions.

are pregnant or plan to become pregnant. It is not known if STELARA will harm your unborn baby. You and your doctor should decide if you will take STELARA.

are breast-feeding or plan to breast-feed. It is thought that STELARA passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take STELARA.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

When prescribed STELARA:

Use STELARA exactly as prescribed by your doctor.

If your doctor decides that you or a caregiver may give your injections of STELARA at home, you should receive training on the right way to prepare and inject STELARA. Do not try to inject STELARA yourself until you or your caregiver has been shown how to inject STELARA by your doctor or nurse.

Common side effects of STELARA include: upper respiratory infections, headache, and tiredness in psoriasis patients; joint pain and nausea in psoriatic arthritis patients; and upper respiratory infections, redness at the injection site, vaginal yeast infections, itching, urinary tract infections, and vomiting in Crohns disease patients. These are not all of the possible side effects with STELARA. Tell your doctor about any side effect that you experience. Ask your doctor or pharmacist for more information.

Please read the full Prescribing Information and Medication Guide for STELARA and discuss any questions you have with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

061408-161010

References

1. About the National Psoriasis Foundation. (n.d.) https://www.psoriasis.org/about-us. Accessed July 24, 2016.

2. National Psoriasis Foundation. About Psoriatic Arthritis. https://www.psoriasis.org/psoriatic-arthritis. Accessed November 3, 2016.

(c) Janssen Biotech, Inc. 2016 11/16 057315-160728

Originally posted here:
My Life with Plaque Psoriasis and How I'm taking Control - The Killeen Daily Herald

(BPT) - Whitney was only 19 years old, home from college freshman year, when her mother noticed spots on her arms and elbows. As any parent would be, Whitneys mother was concerned and suggested her daughter see a dermatologist. That visit revealed her diagnosis of moderate-to-severe plaque psoriasis. Little did Whitney know, this would be a lifelong battle that would impact all aspects of her life.

Plaque psoriasis is a chronic autoimmune skin disease that speeds up the growth cycle of skin cells, causing patches of thick red skin and silvery scales affecting approximately 6 million Americans.1

When I was younger and my psoriasis was flaring, it was very embarrassing and shameful, Whitney said. People didnt understand that I was not contagious. I can remember being turned away by hair stylists who didnt want to cut my hair and being refused a pedicure. My friends and boyfriends didnt understand what was going on with me and I could feel them pulling away at times.

After talking with her doctor about her symptoms, she prescribed a biologic treatment called STELARA (ustekinumab).

I went through some very challenging times with my psoriasis symptoms. Starting treatment with STELARA helped me to take control of my disease and start to create new memories with my family and friends, said Whitney. With clearer skin, I was able to walk down the aisle in a strapless wedding dress, and it was amazing!

Eventually, Whitney would also be diagnosed with psoriatic arthritis, an inflammatory arthritis causing joint pain, stiffness and swelling that affects approximately 30 percent of people with psoriasis.2 STELARA (ustekinumab) also is approved to treat psoriatic arthritis and, over time, Whitneys joint pain and swelling have diminished significantly.

Visit http://www.STELARAINFO.com to learn more about STELARA

WHAT IS STELARA?

STELARA is a prescription medicine approved to treat adults 18 years and older with moderate or severe plaque psoriasis that involves large areas or many areas of their body, who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills).

STELARA is a prescription medicine approved to treat adults 18 years and older with active psoriatic arthritis, either alone or with methotrexate.

STELARA (ustekinumab) works by targeting an underlying cause of plaque psoriasis and psoriatic arthritis an overactive immune system. It blocks two proteins called IL-12 and IL-23 that may play a role in plaque psoriasis and psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

STELARA (ustekinumab) is a prescription medicine that affects your immune system. STELARA can increase your chance of having serious side effects including:

Serious Infections

STELARA may lower your ability to fight infections and may increase your risk of infections. While taking STELARA, some people have serious infections, which may require hospitalization, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses.

Your doctor should check you for TB before starting STELARA and watch you closely for signs and symptoms of TB during treatment with STELARA.

If your doctor feels that you are at risk for TB, you may be treated for TB before and during treatment with STELARA.

You should not start taking STELARA if you have any kind of infection unless your doctor says it is okay.

Before starting STELARA, tell your doctor if you:

think you have an infection or have symptoms of an infection such as:

After starting STELARA, call your doctor right away if you have any symptoms of an infection (see above).

STELARA can make you more likely to get infections or make an infection that you have worse. People who have a genetic problem where the body does not make any of the proteins interleukin 12 (IL-12) and interleukin 23 (IL-23) are at a higher risk for certain serious infections that can spread throughout the body and cause death. People who take STELARA may also be more likely to get these infections.

Cancers

STELARA may decrease the activity of your immune system and increase your risk for certain types of cancer. Tell your doctor if you have ever had any type of cancer. Some people who had risk factors for skin cancer developed certain types of skin cancers while receiving STELARA. Tell your doctor if you have any new skin growths.

Reversible posterior leukoencephalopathy syndrome (RPLS)

RPLS is a rare condition that affects the brain and can cause death. The cause of RPLS is not known. If RPLS is found early and treated, most people recover. Tell your doctor right away if you have any new or worsening medical problems including: headache, seizures, confusion, and vision problems.

Serious Allergic Reactions

Serious allergic reactions can occur. Stop using STELARA and get medical help right away if you have any symptoms such as: feeling faint, swelling of your face, eyelids, tongue, or throat, chest tightness, or skin rash.

Before receiving STELARA, tell your doctor if you:

have any of the conditions or symptoms listed above for serious infections, cancers, or RPLS.

ever had an allergic reaction to STELARA or any of its ingredients. Ask your doctor if you are not sure.

are allergic to latex. The needle cover on the prefilled syringe contains latex.

have recently received or are scheduled to receive an immunization (vaccine). People who take STELARA should not receive live vaccines. Tell your doctor if anyone in your house needs a vaccine. The viruses used in some types of vaccines can spread to people with a weakened immune system, and can cause serious problems. You should not receive the BCG vaccine during the one year before taking STELARA or one year after you stop taking STELARA.

have any new or changing lesions within psoriasis areas or on normal skin.

are receiving or have received allergy shots, especially for serious allergic reactions.

receive or have received phototherapy for your psoriasis.

have any other medical conditions.

are pregnant or plan to become pregnant. It is not known if STELARA will harm your unborn baby. You and your doctor should decide if you will take STELARA.

are breast-feeding or plan to breast-feed. It is thought that STELARA passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take STELARA.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

When prescribed STELARA:

Use STELARA exactly as prescribed by your doctor.

If your doctor decides that you or a caregiver may give your injections of STELARA at home, you should receive training on the right way to prepare and inject STELARA. Do not try to inject STELARA yourself until you or your caregiver has been shown how to inject STELARA by your doctor or nurse.

Common side effects of STELARA include: upper respiratory infections, headache, and tiredness in psoriasis patients; joint pain and nausea in psoriatic arthritis patients; and upper respiratory infections, redness at the injection site, vaginal yeast infections, itching, urinary tract infections, and vomiting in Crohns disease patients. These are not all of the possible side effects with STELARA. Tell your doctor about any side effect that you experience. Ask your doctor or pharmacist for more information.

Please read the full Prescribing Information and Medication Guide for STELARA and discuss any questions you have with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

061408-161010

References

1. About the National Psoriasis Foundation. (n.d.) https://www.psoriasis.org/about-us. Accessed July 24, 2016.

2. National Psoriasis Foundation. About Psoriatic Arthritis. https://www.psoriasis.org/psoriatic-arthritis. Accessed November 3, 2016.

(c) Janssen Biotech, Inc. 2016 11/16 057315-160728

See the original post:
My Life with Plaque Psoriasis and How I'm taking Control - Bloomer ... - Bloomer Advance (subscription)

Back to Browse Journals Psoriasis: Targets and Therapy Volume 7

Ilja L Kruglikov,1 Uwe Wollina2

1Scientific Department, Wellcomet GmbH, Karlsruhe, 2Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany

Abstract: The structure and physiological state of the local white adipose tissue (WAT) located underneath the lesional psoriatic skin and inside of the joints affected by psoriatic arthritis play an important role in the pathophysiology of these diseases. WAT pads associated with inflammatory sites in psoriasis and psoriatic arthritis are, correspondingly, dermal WAT and articular adipose tissue; these pads demonstrate inflammatory phenotypes in both diseases. Such local WAT inflammation could be the primary effect in the pathophysiology of psoriasis leading to the modification of the local expression of adipokines, a change in the structure of the basement membrane and the release of keratinocytes with consequent epidermal hyperproliferation during psoriasis. Similar articular adipose tissue inflammation can lead to the induction of structural modifications and synovial inflammation in the joints of patients with psoriatic arthritis.

Keywords: psoriasis, psoriatic arthritis, pathophysiology, adipose tissue, dermal adipocytes, articular adipose tissue

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

The rest is here:
Local effects of adipose tissue in psoriasis and psoriatic arthritis - Dove Medical Press

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LeAnn Rimes is a country music superstar who's been making hit records since she was only 13 years old. The powerhouse vocalist reflects on growing up in the spotlight and how she's been able to embrace her insecurities and own them with confidence!

One of my biggest insecurities is my skin. I've had psoriasis since I was 2 and was 80 percent covered by the time I was 6, so I was constantly in a state of covering up everything as a kid and feeling really uncomfortable.

RELATED: LeAnn Rimes shares adorable throwback photo from her first cassette tape

I didn't realize how much it had impacted my self-confidence and just really kind of feeling like a woman.

LeAnn Rimes isn't afraid to bare her skin after managing her psoriasis.

So there's been a ton of bikini photos of me in the past several years; it's because I would go naked if I could because I'm clear and it's all good!

I think music really was what gave me confidence.

RELATED: Ashley Graham: What I tell myself in the mirror to feel confident

I think I was very disconnected from my body so that was the one way I could really connect. So I think music has been a very, very healing thing for me.

"Music ... was a place for me to be able to escape in a way but also kind of come out of my shell."

I never thought I could get to the place where I could really be grateful for every single thing that's happened in my life ... but I am now and it feels really good.

RELATED: 'Forever Country' brings singers from past and present together for epic video

As I get older, I've learned how to accept the things that bother me about myself and really start to love those things. They're what make me, me.

My advice to others is to own it. Own who you are, because it feels really good when you do.

As told to TODAY's Jordan Muto.

Originally posted here:
LeAnn Rimes: Psoriasis is 'one of my biggest insecurities' - Today.com