Page 205«..1020..204205206207..210220..»

Category Archives: Transhuman News

Atopic eczema and alopecia areata – zayqif.hydra-market.shop

Posted: August 29, 2022 at 7:30 am

2021. 9. 21. Eczema can also lead to patches of inflamed, oozing, crusting skin. Find out more about symptoms here. The first sign of eczema is a dry, itchy rash. Eczema can also lead to patches of inflamed, oozing, crusting skin. Find out more about symptoms here. Menu. Newsletters Search. .

2022. 6. 30. Atopic conditions: Atopic dermatitis (eczema), allergies, and/or asthma may raise the risk. Autoimmune diseases: Thyroid conditions, lupus, psoriasis, rheumatoid arthritis, or vitiligo may contribute. Race: A 2018 analysis found alopecia areata to be more common in people who are Black or Hispanic, at least in the case of women.

2021. 9. 21. Eczema can also lead to patches of inflamed, oozing, crusting skin. Find out more about symptoms here. The first sign of eczema is a dry, itchy rash. Eczema can also lead to patches of inflamed, oozing, crusting skin. Find out more about symptoms here. Menu. Newsletters Search. Manual de dermatologia clnica de Sampaio e Rivitti.

La Bibliothque Virtuelle de Sant est une collection de sources d'information scientifiques et techniques en sant, organise et stocke dans un format lectronique dans les pays de la Rgion d'Amrique Latine et des Carabes, universellement accessible sur Internet et compatible avec les bases de donnes internationales. The most common type of eczema is known as atopic dermatitis, or atopic eczema. Atopic refers to a group of diseases with an often inherited tendency to develop other allergic conditions, ... Of the 21 autoimmune diseases studied, 17 were found to be linked to psoriasis, including alopecia areata, celiac disease, scleroderma, lupus,.

Locating mesenchymal stem cells in the human hair follicle dermal papilla by focal plane array-fourier transform infrared spectroscopy. 2019. 4. 2. Darrigade AS, Legrand A, Andreu N, Jacquemin C, Boniface K, Taieb A, et al. Dual efficacy of dupilumab in a patient with concomitant atopic dermatitis and alopecia areata. Br J Dermatol 2018; 179: 534536. View article Google Scholar; Penzi LR, Yasuda M, Manatis-Lornell A, Hagigeorges D, Senna MM. Hair regrowth in a patient with long-standing alopecia totalis.

Autoimmune, atopic, and mental health comorbid conditions associated with alopecia areata in the United States. JAMA Dermatol . 2013;149(7):789-794.doi: 10.1001/jamadermatol.2013.3049 Guo H, Cheng.

.

2020. 8. 31. Do alopecia Areata and Atopic Dermatitis share HLA alleles and cytokine profiles? UT-MD Anderson Cancer Center Nazila Barahmani, M.D. NEASE/NAAF-Final Report July, 2005 Alopecia areata (AA) is hypothesized to be an organ-specific autoimmune disease mediated by T cells directed to the hair follicle. The severity of the clinical phenotype. . 2021. 8. 17. Alopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in hair loss, that affects up to 2% of the general population. The exact pathobiology of AA has still remained elusive, while the common theory is the collapse of the immune privilege of the hair follicle caused by immunological mechanism. Multiple genetic and environment factors.

IMPORTANCE: Previous studies found conflicting results as to whether atopic dermatitis (AD) is increased in patients with vitiligo and alopecia areata (AA). OBJECTIVE: To compare the prevalence of AD between patients with either vitiligo or AA and those without these disorders by performing a meta-analysis of observational studies. 2017. 6. 6. Introduction. Alopecia areata (AA) is a complex genetic, immune-mediated disease that targets hair follicles. The disease affects children and adults and is characterised by round or oval patches of hair loss, loss of all scalp hair (alopecia total), body hair (alopecia universal) or opiates pattern hair loss [].AA could be associated with asthma, allergic rhinitis, atopic.

2022. 3. 25. Pfizer Announces a Quality Improvement Grant RFP Innovative Solutions in Atopic Dermatitis and Alopecia Areata Management . 2022 I&I IT INNOVA-DERMA. Competitive Grant Program using Expert Review Panel . I. Background . Pfizer Global Medical Grants (GMG) supports the global healthcare communitys independent initiatives. La Bibliothque Virtuelle de Sant est une collection de sources d'information scientifiques et techniques en sant, organise et stocke dans un format lectronique dans les pays de la Rgion d'Amrique Latine et des Carabes, universellement accessible sur Internet et compatible avec les bases de donnes internationales. Associated Disease Condition: Individuals suffering from other autoimmune skin diseases, such as psoriasis, atopic dermatitis (eczema), and lichen planus, are prone to develop alopecia areata. For instance, a person having psoriasis of the scalp has scaling, and itchy skin which leads to hair loss, thereby causing bald patches in the affected area. Daily application of fluocinonide 0.1% cream for the treatment of atopic dermatitis Once- or twice-daily topical application of fluocinonide 0.1% cream for 14 days was safe and effective for treating atopic dermatitis in this adult patient population. The efficacy of once-daily application was comparable to twice-daily application.

Alopecia areata (AA) is an immunologic hair loss disorder that results in non-scarring hair loss 1.The severity of AA is divided according to the extent of hair loss of the scalp 2.Although not a life-threatening condition, moderate to severe AA reduces health-related quality of life (QoL) and is also associated with psychological disorders such as depression and anxiety 3, 4.

2018. 6. 1. Mohan et al. 14 assessed the association between AE and vitiligo (16 studies, 10 200 patients from 11 countries) and alopecia areata (17 studies, 798 597 patients from 11 countries). Pooled data from two studies showed a positive association between vitiligo and AE (OR = 7.82, 95% CI 3.0620.00).

Eczema (also known as dermatitis) is a non-contagious dry skin condition that can affect people of all ages, including 1 in 10 adults and 1 in 5 children in the UK. Atopic eczema is the most common form of eczema and tends to run in families. Atopic is a term used to describe the tendency to develop eczema, asthma and hay fever.

Atopic dermatitis (AD) is a hereditary, and chronically relapsing inflammatory skin disease characterized by a perivascular infiltrate of activated T-cells. Like AA, AD also may be triggered by environmental factors such as stress or viral infections. The incidence of having both AA and AD has been reported to be 10-60%. Patients with.

2012. 10. 3. Alopecia areata (AA) is an autoimmune disease that presents with nonscarring hair loss from some or all hair-bearing areas of the body, typically the scalp. Its reported prevalence in the United States is in the 0.1% to 0.2% range, but it can be as high as 0.7% to 3.8% in dermatology patients. 1,2 It has a tremendous effect on patients quality of life, but.

Importance: Previous studies found conflicting results as to whether atopic dermatitis (AD) is increased in patients with vitiligo and alopecia areata (AA). Objective: To compare the prevalence of AD between patients with either vitiligo or AA and those without these disorders by performing a meta-analysis of observational studies..

Read the original post:
Atopic eczema and alopecia areata - zayqif.hydra-market.shop

Posted in Eczema | Comments Off on Atopic eczema and alopecia areata – zayqif.hydra-market.shop

fort worth map with zip codes – prxrzj.rids-gear.shop

Posted: at 7:30 am

Having dealt with eczema since she was a toddler, she has extensive experience with all of the many over-the-counter eczema products, shampoos included, out there. According to our Diversity Pledge , 15% of products in our newly-published market roundups will feature Black-owned and/or Black-founded brands. Formulated as an over-the-counter treatment for people with eczema, psoriasis, and sensitive skin, Bodewell's Anti-Inch Cream helps curb redness, burning, dryness, and irritation.

May 04, 2022 Apply a dressing or wet wrap. Avoid scratching the skin. Avoid harsh soaps, lotions, or detergents. You may find that a bath soothes the skin. Some bath treatments that might help include soaking in a full tub of lukewarm water with one of the following: cup of baking soda to relieve itching.. Buy on Amazon. Puriya has been making great treatments for years, thanks to a combination of clever design and appropriate materials. The Puriya Over The Counter Topical Eczema Treatment has cracked feet, has a light scent and it is great for inner thighs. Gently effective and made just for you in a non greasy cream.

smokey mountain map

OTC hydrocortisone is often the first thing doctors recommend to treat mild eczema. You may need different strengths of these steroids, depending on where and how bad your rash is. For.

Visit link:
fort worth map with zip codes - prxrzj.rids-gear.shop

Posted in Eczema | Comments Off on fort worth map with zip codes – prxrzj.rids-gear.shop

Ear Eczema: Symptoms, Causes, and Treatments – Healthgrades

Posted: at 7:30 am

Ear eczema is a skin condition that causes itchy, red patches on or inside the ear. Another name for eczema is atopic dermatitis, which is basically skin inflammation that is itchy. There is no cure for ear eczema, but treatments can help manage symptoms.Ear eczema is more common in children but can also develop in adults.

This article discusses what ear eczema is, ear eczema symptoms, its causes, and how to treat it.

Eczema is a chronic inflammatory skin condition that causes patches of red, scaly, or itchy skin in or around the area affected. Eczema is not contagious and is more common in children.

Ear eczema can occur in the ears, behind the ears, in the ear canal, on the earlobes or ear fold (pinna), or on the ear drum. Symptoms range from mild skin dryness to extensive skin loss and irritation.

Eczema can sometimes run in families, so you may have a higher chance of developing eczema if a close family member has the condition. Food allergies can be a trigger for eczema, especially in younger children. Your doctor may ask you to keep a food diary to track your eczema symptoms.

Because ear eczema results in skin breakdown, there is an increased risk of developing skin infections. Otitis externa, also known as swimmers ear, is sometimes caused by skin problems such as ear eczema.

Ear eczema symptoms can also become exacerbated due to certain ear-piercing materials, such as nickel.

Several types of eczema can affect the ears and the skin behind the ears:

Symptoms of ear eczema include:

Ear eczema often looks like red, scaly patches in or around the ear. A common site for this to occur in people with atopic ear eczema is the junction between the earlobe and face. Sometimes painful cracks or fissures occur in this area, which can become easily infected.

Seborrheic dermatitis on the ears typically looks like itchy, flaky skin with a yellowish, greasy scale. This type of eczema is sometimes confused with psoriasis.

Weeping of the skin is usually a sign that the area of eczema has become infected. With weeping eczema, the area oozes clear or straw-colored fluid and may have fluid-filled blisters.

Ear eczema is believed to be caused by a gene mutation called filaggrin. When someone has this gene mutation, their skin is unable to repair damage to its skin barrier.

Normally, each skin cell has two copies of the filaggrin gene. But people at risk for developing eczema only have one copy of this gene.

When the skin barrier becomes disrupted, moisture leaves the skin and it becomes dry and flaky. Environmental allergens can also enter the skin and trigger an immune system response, causing the skin to become inflamed.

Eczema is more likely to occur if you have a family history of eczema or if you have an allergic condition, such as hay fever or asthma. Stress does not cause eczema.

While its not possible to prevent ear eczema, you can manage your symptoms with the following tips:

Your doctor will diagnose ear eczema by looking at your ear and examining your skin. They may ask you some questions, such as:

You do not need any lab or imaging tests to be diagnosed with ear eczema. To be diagnosed with ear eczema, the itchy skin condition must be present during the past 12 months.

Ear eczema treatments depend on the type and cause of eczema. Treatments for eczema include both at-home remedies and medical treatment. Talk with your doctor about which treatments are best for your ear eczema. Treatments may include:

The most common complication of ear eczema is a skin infection. Weeping of the skin is the most common sign of infection. Infection is more likely to occur in areas of the ear where cracks have developed, such as the juncture of the ear and face and on the ear folds.

Its also possible to develop an ear infection from ear eczema. The most common type of ear infection to occur is otitis externa, which is an infection of the outer part of the ear. This type of infection is also known as swimmers ear.

Symptoms include:

In severe cases, hearing can be affected.

People with eczema are more prone to bacterial and viral skin infections such as impetigo, herpes simplex virus (cold sores), and warts.

Ear eczema is a skin condition characterized by red, itchy patches on the skin of the ear.

Ear eczema is more common in people with a family history of eczema or in those with allergic conditions. Certain foods and contact with environmental irritants can trigger eczema. In some cases, an infection can occur in the area of eczema.

The most common form of treatment for ear eczema is moisturizers and topical steroids. In cases that dont respond to these treatments, oral medications are used.

Read the original here:
Ear Eczema: Symptoms, Causes, and Treatments - Healthgrades

Posted in Eczema | Comments Off on Ear Eczema: Symptoms, Causes, and Treatments – Healthgrades

The Mutha Body Oil Is Worth the Splurge, Especially If You Have Sensitive Skin – POPSUGAR

Posted: at 7:30 am

I have eczema, and I've found that it can very easily be triggered by the body moisturizing products I use. For a while, I had found a holy-grail body lotion, but it's summertime, and in California, it's blisteringly hot. The body lotion I had been using is super thick, and it was sort of sitting on top of my skin. While it's perfect for winter, I knew I needed a lightweight product that was still deeply nourishing for my dry skin, so I searched for a body oil. As someone who's very particular about body products, I have fallen in love with the Mutha Body Oil ($104).

I love this body oil because it's substantial enough to be nourishing for my dry skin and it actually soaks in, leaving my body soft and hydrated. I use it after I get out of the shower, and I appreciate how quickly I can put my pajamas on afterward; it soaks into my skin almost immediately. I also adore the smell; it's not artificially fragranced, but it's a little bit sweet and a little bit citrusy. If I had to guess, I'd say the scent comes primarily from the sweet almond oil, orange-peel oil, and grapefruit-peel oil. It has a slightly yellow and orange tint to it, and it makes my skin glow or look like I just came from the beach, but there's no transfer to my white sheets. You can see the way the oil looks rubbed into my skin in the picture below. I also like that the Mutha Body Oil ($104) is a 100 percent botanical oil, made from certified organic plant extracts and oils, and is free of parabens, sulfates, and petroleum. I've found that my skin tends to respond better to products with hydrating bases like coconut oil or rosehip oil, but this is not a general prescription; it's important to try to find what works for you, particularly if you're dealing with a condition like eczema, and consult with your doctor as needed.

The Mutha Body Oil ($104) was formulated by the founder of Mutha when she was pregnant, so it's safe for those who are expecting. The main ingredient in this product is rosehip oil, which is known for its moisture-retaining benefits. It's also packed with vitamin E, which is essential for reducing inflammation caused by a condition like eczema, and vitamin A, which can both naturally tighten and firm the skin as well as help even out skin tone and even be used to treat the appearance of scars or stretch marks.

If you have skin conditions or really sensitive skin and have struggled to find a quality, nonirritating body product, the Mutha Body Oil ($104) is a game changer. It's the ideal summertime hydrator for all skin types and is also a great product that's safe for pregnancy.

The short answer to this is yes, with an asterisk. For full transparency, this product was sent to me by the brand. I have really sensitive skin on my body and have found most body lotions, butters, and creams to trigger my eczema. For me, finding a quality product that actually nourishes without irritating is worth its weight in gold, and I'd happily pay the price, though it's definitely pricey. However, if you don't have skin sensitivity or trouble finding a great moisturizer, you could probably get away with a less expensive product.

A portion of all proceeds of Mutha products are donated to International Medical Corps, a nonprofit organization that helps mothers around the globe deliver their children safely.

You can find this product on the Mutha website, as well as at Violet Grey, Net-a-Porter, and FRWD.Rating:

Image Source: POPSUGAR Photography / India Yaffe

Here is the original post:
The Mutha Body Oil Is Worth the Splurge, Especially If You Have Sensitive Skin - POPSUGAR

Posted in Eczema | Comments Off on The Mutha Body Oil Is Worth the Splurge, Especially If You Have Sensitive Skin – POPSUGAR

Are You Allergic to Your Beauty Products? A Patch Test Might Tell You – Allure

Posted: at 7:30 am

"She was routinely rubbing into the mat while sweaty, so the allergen absorbs quickly," she explains. Other such mystery cases were caused by the sulfites in beer, and for one baker, her severe hand eczema came from daily contact with kneading dough laced with Balsam of Peru, a substance found in ingredients like cinnamon.

Dr. Bordone recently saw a patient with red, swollen eyelids who had swapped all her products with new brands, stopped wearing eye makeup, and pared down her routine to just concealer, but was still reacting. "It turned out it was the rubber in her makeup sponges. She lived with this for over a year before she came in for patch testing and we identified the rubber allergy," says Dr. Bordone.

Fragrance and preservative ingredients are common triggers in beauty and personal-care products. Methylisothiazolinone, commonly called MI, tops the list, according to Dr. Bordone, along with Paraphenylenediamine (PPD), which is widely used in permanent hair dyes that frequently causes severe allergies. "They can appear all over the body and people don't often make the connection with their hair dye, because they think that will only manifest on the scalp. However, you can get severe eyelid swelling and a rash all over the body," says Dr. Lazic Strugar.

Fragrances, both synthetic and natural that include essential oils, can be allergy-inducing. Linalool and limonene are two citrus-derived fragrance compounds that are common culprits. "If patients get skin-care products from Whole Foods and it's organic, they think it's not causing their rash, but essential oils are actually very sensitizing," Dr. Lazic Strugar says.

Allergies to these ingredients aren't always instant. In fact, people sometimes notice that they develop allergies to a product after months or even years, and struggle to believe they're now allergic to it after using it reliably for so long. That's because of a phenomenon called cumulative exposure, which is usually how ACD develops. "It never happens the first time you touch something. Your body needs to see it at least twice to get sensitized to it and then produce this memory immune response every time it sees that chemical," says Dr. Lazic Strugar.

A very common example of that is the notorious Neosporin allergy. Neosporin, a topical antibiotic, has become a product that some dermatologists have condemned. "Neomycin, the main active ingredient, is very highly sensitizing. It's commonly used and people tend to overuse it, slathering it on cracked, dry skin, or chapped lips. In those cases, when you're using it on an already compromised skin barrier, it's more likely to cause an allergic reaction," she says. But before you begin to suspect all your beauty products of irritating your skin, check in with your dermatologist or allergist to see if a patch test is right for you.

See more here:
Are You Allergic to Your Beauty Products? A Patch Test Might Tell You - Allure

Posted in Eczema | Comments Off on Are You Allergic to Your Beauty Products? A Patch Test Might Tell You – Allure

Stinky sweat turns out to have a surprising health benefit : Goats and Soda – NPR

Posted: at 7:30 am

Tennis great Rafael Nadal of Spain might think twice about shaking off his beads of perspiration. It turns out that sweat leads to a surprising health benefit. Matthew Stockman/Getty Images hide caption

Tennis great Rafael Nadal of Spain might think twice about shaking off his beads of perspiration. It turns out that sweat leads to a surprising health benefit.

Back in college, I had an embarrassing moment that's forever etched into my memory. A girlfriend borrowed my backpack for a weekend trip. And when she came back, she handed me the backpack and said something I'll never forget:

"Michaeleen, you must sweat a lot because your backpack stinks. The armstraps smell like onions. Ew."

I stood there in silence, feeling totally ashamed. I'm not sure how I responded. But I remember thinking to myself, "I don't eat many onions. Does my sweat really smell that bad?"

Now 25 years later, I've come to find out that my stinky sweat was actually a signal of something good on my skin something that prevents skin problems, like eczema, and protects me from dangerous infections such as MRSA,, which is found in hospitals around the world and is the leading cause of skin infections in the U.S.

To figure out what I'm talking about, we need to step back and look at what actually creates body odor. It's not the sweat itself.

"No, I don't think your sweat by itself smells," says microbiologist Gavin Thomas at York University. "It certainly doesn't have these really stinky, odorous molecules."

Thomas studies how and why humans have a particular bouquet of scents. He says that sweat, immediately after it comes out of your pores, is essentially odorless.

"So most sweat is salty water," he says. That's the sweat that's secreted pretty much all over your body and cools you down when you're hot.

"But that's not what we're interested in," he explains. "We're interested in this other type of sweat, which is produced in our underarms and around the genitals."

This other type of sweat isn't just salty water but also contains a cornucopia of compounds, including oils, fats and proteins.

No one knows exactly why humans have this second type of sweat. But, Thomas says, one purpose likely has to do with the odors that it ends up emitting.

On its own, this second type of sweat isn't smelly. But something living on our skin tiny creatures takes that sweat and makes it stinky.

Yes, I'm talking about the bacteria on your skin.

Warning: This illustration "grossed out" our visuals editor! It depicts bacteria around a sweat gland pore on the surface of human skin. Sweat pores bring sweat from a sweat gland to the skin's surface. Some of these bacteria enjoy eating the molecules in our sweat. Then they spit out new molecular compounds, some of which can be quite stinky. Juan Gaertner/Science Source hide caption

"The human skin has almost 200 different species of bacteria living on it," says biologist Teruaki Nakatsuji at the University of California, San Diego. "And each person has different strains of these bacteria. So the skin microbiota is so diverse."

These bacteria are hungry. And some of them really enjoy eating the molecules in our sweat. They munch off a piece of the molecule and then spit out new molecular compounds, some of which are quite aromatic. For example, they can smell like cumin or goats, the American Society for Microbiology asserts.

And some of these molecules are downright stinky.

Back in 2020, Thomas and his colleagues found that one critter on the skin, called Staphylococcus hominis, produces an especially pungent odor: "We've had people describe it as kind of an onion smell or a cheesy onion smell," he says. "These types of compounds do smell pretty bad."

So back in college, when my backpack smelled a bit stinky, it wasn't so much my sweat to blame but rather a little microbe called Staphylococcus hominins.

Which may make you want to go take shower stat. But wait! Before you go grab the antibacterial soap, there's something about this bacteria you need to know. Something that I didn't realize until recently: These bacteria and their relatives actually do something really good for you and your skin. In fact, you need these bacteria.

"Without S. hominins, you're in trouble," says dermatologist Richard Gallo at the University of California, San Diego.

Over the past five years, Gallo, Teruaki Nakatsuji and their colleagues have published a series of studies showing how S. hominins actually protects our skin from inflammatory problems, such as eczema, and dangerous infections, including Methicillin-resistant Staphylococcus aureus, or MRSA.

The team has even developed a cream, made with the bacteria and tested in preliminary trials, as a treatment for eczema.

"S. hominins basically make a type of antibiotic, which specifically targets the bacteria that causes MRSA," Gallo says. "And it kills this bacteria by punching holes in its cell membrane."

But, Gallo says, this critter isn't the only part of your skin that produces antimicrobial agents. Twenty years ago, he and his colleagues found that your body itself also makes antimicrobial molecules and puts them inside your sweat.

"So sweat is almost like an antibiotic juice," Gallo says. "And as the water evaporates, those antibiotics actually increase in concentration. So it kind of leaves a little coating on your skin. So that's one of the ways our skin tries to fight the bad bacteria."

So the next time you're hot, sticky and maybe a bit stinky, before you hit the shower, take a moment to thank your sweat and the bacteria that eat it for helping to keep your skin healthy and safe.

Because even after you do take a shower, the protective critters will still be there to help you, Gallo says even if you use antibacterial soap.

"When you wash your skin, you get rid of the material on its surface," he says. But these bacteria live deep inside your skin's pores, where detergents and antibiotics can't reach. "So within 10 minutes after washing, the bacteria grow back and populate your skin's surface.

"So in a way, your skin is smarter than you," he adds. It knows what it needs better than you do.

Go here to read the rest:
Stinky sweat turns out to have a surprising health benefit : Goats and Soda - NPR

Posted in Eczema | Comments Off on Stinky sweat turns out to have a surprising health benefit : Goats and Soda – NPR

Similar faces share similar DNA – EL PAS USA

Posted: at 7:28 am

Examples of photographs of virtual doubles (with similar facial features, but without family ties) used in the research published in the journal 'Cell Reports'FRANOIS BRUNELLE

Our faces, at first glance, are what differentiate us from one another. Sometimes, though, people can look virtually identical, even if they dont have any shared blood. Spanish researchers have discovered that these lookalikes actually have more than superficial features in common in fact, they may even have genetic similarities.

What unites lookalikes the most is their DNA sequence, says lead scientist Manel Esteller, who has published his groups findings in the scientific journal Cell Reports. Genomics groups them together.

The study reveals that genetic similarities may not only result in facial resemblances, but also in similar habits or behaviors. The results will likely have long-term implications within the forensic sciences.

The researchers identified pairs of virtual doppelgangers by looking through the works of photographer Franois Brunelle, a Canadian artist who has spent more than 20 years taking images of lookalikes around the world. The researchers subsequently passed them through facial recognition programs so that algorithms could verify the similarities. The 32 pairs that were eventually recruited ended up having confirmed resemblances in three recognition systems, with scores similar to those obtained by identical twins. Biological samples were then taken from the 64 participants, who were then subjected to exhaustive questionnaires about their habits and lifestyles.

In 2005, we discovered that identical twins, called monozygotes, had the same DNA. I then decided to look at people who looked alike, but werent twins. I wanted to know how much [of that resemblance] came from nature or from the environment that surrounded them, explains Esteller.

The researchers looked at the genome, but also at the epigenome, which can attach to DNA and cause functional changes, like a kind of switch that conditioned by environments or habits turns off or turns on the activity of genes. The scientists also analyzed the microbiome of the participants, or the ecosystem of microorganisms that populate a human being.

We found that what binds [each pair of virtual doubles] the most is their DNA sequence, their genomes. By chance, similar genomes end up being produced [in unrelated people]. Thats because there are so many people in the world that DNA is repeated, explains Esteller. They are not identical, but they share similarities, the researcher specifies: Similarities in their genomes explain the similarity of these pairs; however, the different composition of their epigenomes helps to differentiate them.

The research offers clues about the genetic environment associated with facial appearance. For example, genetic variations shared by the doubles were associated with physical characteristics, such as lip or eye color, hip circumference, height, body mass index or hair. But the research suggests that these molecular similarities found influence beyond the construction of the face. The study points out a facial correlation with certain physical attributes, habits and behaviors:

We saw that there is greater genetic determination in whether [the participants] are left-handed or right-handed, or prone to addictions like smoking.

Through the lifestyle questionnaires and biometric parameters, the article points out that, in matters such as height, weight, level of education or smoking habits, those who are superficially similar have more in common than those who do not look alike.

The researchers admit that there are some limitations in their study, such as the small number of participants, the fact that the majority were European, or that the photos were in black-and-white, resulting in a lack of definition of skin tone and features. But Esteller is confident that, despite all of this, the study opens a new door in the scientific community and points to two possible derivatives:

It may have forensic implications, because from an unknown genome, you can start to construct a face. And, on the other hand, by looking at a face, we can also begin to deduce the genome of the person. For example, if they have a certain kind of face, they may be more or less at risk of cardiovascular disease,

ngel Carracedo, a geneticist at the Institute of Forensic Sciences of the University of Santiago de Compostela who did not participate in the study notes that, while the results are interesting, they do not currently have direct application in the forensic field. It is, for now, an exploratory work

but the study broadens perspectives in the forensic field, which uses some biomarkers, he says, such as the biological witnesses in police investigations.

At the moment, the physical characteristics that can be determined with a good level of prediction for forensic purposes are pigmentation (especially eye and skin color), hair type and little else new genes are very important to explore other facial and physical characteristics.

Carracedo who leads a project to design techniques that determine the physical characteristics, biographical origins and ages of people based on their DNA agrees, however, that all of this must continue to be studied, replicated and validated, while meeting the highest forensic standards.

Read more:
Similar faces share similar DNA - EL PAS USA

Posted in DNA | Comments Off on Similar faces share similar DNA – EL PAS USA

Scientists race to digitize DNA of every known species on the planet – CBS News

Posted: at 7:28 am

Scientists around the world are racing to record the genetic blueprints of every known species on the planet. The effort comes as the United Nationswarns that an estimated one million plant and animal species are at risk of becoming extinct within the coming decades.

"This is absolutely urgent," researcher Joanna Harley told CBS News correspondent Roxana Saberi. "It's really important to protect species on this planet. They share with us and they keep us going and the more we erode away at the world, the less there will be."

Around 5,000 scientists across the globe are part of the Earth BioGenome Project. Over the next decade, teams will digitize DNA of the 1.8 million named plant, animal, fungi and single-celled eukaryote species on the planet. By the end of 2022, the scientists plan on sequencing 3,000 genomes.

By DNA sequencing life on Earth, the researchers have goals of benefitting human welfare, protecting biodiversity and better understanding ecosystems.

"Everything's interconnected," Mark Blaxter, who leads a group working under the Earth BioGenome Project, told Saberi. "We need the services that these plants and animals and fungi give us...so by understanding how they do it, we can help humans as well."

So far, researchers in Britain have recorded the genetic blueprints of nearly 400 of the country's 70,000 known species.

The lengthy process begins with researchers like Harley who help search for species. The collected specimens are then sent for sorting before they're shipped off to sequencing labs. The data is then shared online.

"We'll be able to look at a species and work out whether it's endangered or not, and we'll know what to do to keep it going," Blaxter said.

The scientists added that decoding DNA won't save endangered plants and animals alone, but that it can be beneficial as more species are on the track of extinction.

Trending News

Tori B. Powell is a breaking news reporter at CBS News. Reach her at tori.powell@viacomcbs.com

Continue reading here:
Scientists race to digitize DNA of every known species on the planet - CBS News

Posted in DNA | Comments Off on Scientists race to digitize DNA of every known species on the planet – CBS News

Scientists Discover Surprise Anticancer Properties of Common Lab Molecule | Newsroom – UNC Health and UNC School of Medicine

Posted: at 7:28 am

Experiments from the UNC School of Medicine lab of Nobel Prize-winning scientist Aziz Sancar, MD, PhD, show how a common molecular tool for DNA labeling also has anticancer properties worthy of further investigation, especially for brain cancers.

CHAPEL HILL, NC Scientists at the UNC School of Medicine have made the surprising discovery that a molecule called EdU, which is commonly used in laboratory experiments to label DNA, is in fact recognized by human cells as DNA damage, triggering a runaway process of DNA repair that is eventually fatal to affected cells, including cancer cells.

The discovery, published in the Proceedings of the National Academy of Sciences, points to the possibility of using EdU as the basis for a cancer treatment, given its toxicity and its selectivity for cells that divide fast.

The unexpected properties of EdU suggest it would be worthwhile to conduct further studies of its potential, particularly against brain cancers, said study senior author Aziz Sancar, MD, PhD, the Sarah Graham Kenan Professor of Biochemistry and Biophysics at the UNC School of Medicine and member of the UNC Lineberger Comprehensive Cancer Center. We want to stress that this is a basic but important scientific discovery. The scientific community has much work ahead to figure out if EdU could actually become a weapon against cancer.

EdU (5-ethynyl-2-deoxyuridine) is essentially a popular scientific tool first synthesized in 2008 as an analog, or chemical mimic, of the DNA building block thymidine which represents the letter T in the DNA code of adenine (A), cytosine (C), guanine (G) and thymine (T). Scientists add EdU to cells in lab experiments to replace the thymidine in DNA. Unlike other thymidine analogs, it has a convenient chemical handle to which fluorescent probe molecules will bond tightly. It thus can be used relatively easily and efficiently to label and track DNA, for example in studies of the DNA replication process during cell division.

Since 2008, scientists have used EdU as a tool in this way, as published in thousands of studies. Sancar, who won the 2015 Nobel Prize for Chemistry for his seminal work on DNA repair, is one such scientist. When his lab began using EdU, his team unexpectedly observed that EdU-labeled DNA triggered a DNA repair response even when it wasnt exposed to DNA-damaging agents, such as ultraviolet light.

That was quite a shock, Sancar said. So we decided to explore it further.

Following up on the strange observation, the team discovered that EdU, for reasons that are still unclear, alters DNA in a way that provokes a repair response called nucleotide excision repair. This process involves the removal of a short stretch of damaged DNA and re-synthesis of a replacement strand. This is the mechanism that repairs most damage from ultraviolet light, cigarette smoke, and DNA-altering chemo drugs. The researchers mapped EdU-induced excision repair at high resolution and found that it occurs across the genome, and it apparently occurs again and again, since each new repair strand includes EdU and thus provokes the repair response anew.

It had been known that EdU is moderately toxic to cells, though the mechanism of its toxicity had been a mystery. The teams findings strongly suggest that EdU kills cells by inducing a runaway process of futile excision repair, which ultimately leads the cell to terminate itself through a programmed cell-death process called apoptosis.

That discovery was interesting in its own right, Sancar said, because it suggested that researchers using EdU to label DNA need to take into account its triggering of runaway excision repair.

As we speak, hundreds and maybe thousands of researchers use EdU to study DNA replication and cell proliferation in lab experiments without knowing that human cells detect it as DNA damage, Sancar said.

Sancar and colleagues also realized that EdUs properties might make it the basis for an effective brain cancer drug because EdU becomes incorporated into DNA only in cells that are actively dividing, whereas, in the brain, most healthy cells are non-dividing. Thus, in principle, EdU could kill fast-dividing cancerous brain cells while sparing non-dividing, healthy brain cells.

Sancar and his team hope to pursue follow-up collaborations with other researchers to investigate EdUs properties as an anticancer agent.

Prior studies have already found evidence that EdU kills cancer cells, including brain cancer cells, but strangely, no one has ever followed up on those results, Sancar said.

Nucleotide excision repair removes thymidine analog 5-ethynyl-2-deoxyuridine from the mammalian genome was co-authored by Li Wang, Xuemei Cao, Yanyan Yang, Cansu Kose, Hiroaki Kawara, Laura Lindsey-Boltz, Christopher Selby, and Aziz Sancar. Funding was provided by the National Institutes of Health (GM118102, ES02755).

Media contact: Mark Derewicz, UNC School of Medicine, 919-923-0959

Read this article:
Scientists Discover Surprise Anticancer Properties of Common Lab Molecule | Newsroom - UNC Health and UNC School of Medicine

Posted in DNA | Comments Off on Scientists Discover Surprise Anticancer Properties of Common Lab Molecule | Newsroom – UNC Health and UNC School of Medicine

We Think Denbury (NYSE:DEN) Might Have The DNA Of A Multi-Bagger – Yahoo Finance

Posted: at 7:28 am

If you're looking for a multi-bagger, there's a few things to keep an eye out for. One common approach is to try and find a company with returns on capital employed (ROCE) that are increasing, in conjunction with a growing amount of capital employed. Ultimately, this demonstrates that it's a business that is reinvesting profits at increasing rates of return. With that in mind, the ROCE of Denbury (NYSE:DEN) looks great, so lets see what the trend can tell us.

If you haven't worked with ROCE before, it measures the 'return' (pre-tax profit) a company generates from capital employed in its business. To calculate this metric for Denbury, this is the formula:

Return on Capital Employed = Earnings Before Interest and Tax (EBIT) (Total Assets - Current Liabilities)

0.24 = US$378m (US$2.1b - US$539m) (Based on the trailing twelve months to June 2022).

So, Denbury has an ROCE of 24%. That's a fantastic return and not only that, it outpaces the average of 16% earned by companies in a similar industry.

Check out our latest analysis for Denbury

roce

In the above chart we have measured Denbury's prior ROCE against its prior performance, but the future is arguably more important. If you're interested, you can view the analysts predictions in our free report on analyst forecasts for the company.

Denbury has not disappointed in regards to ROCE growth. We found that the returns on capital employed over the last five years have risen by 450%. That's a very favorable trend because this means that the company is earning more per dollar of capital that's being employed. Interestingly, the business may be becoming more efficient because it's applying 61% less capital than it was five years ago. If this trend continues, the business might be getting more efficient but it's shrinking in terms of total assets.

On a side note, we noticed that the improvement in ROCE appears to be partly fueled by an increase in current liabilities. The current liabilities has increased to 25% of total assets, so the business is now more funded by the likes of its suppliers or short-term creditors. Keep an eye out for future increases because when the ratio of current liabilities to total assets gets particularly high, this can introduce some new risks for the business.

Story continues

In the end, Denbury has proven it's capital allocation skills are good with those higher returns from less amount of capital. And investors seem to expect more of this going forward, since the stock has rewarded shareholders with a 29% return over the last year. So given the stock has proven it has promising trends, it's worth researching the company further to see if these trends are likely to persist.

Like most companies, Denbury does come with some risks, and we've found 1 warning sign that you should be aware of.

If you'd like to see other companies earning high returns, check out our free list of companies earning high returns with solid balance sheets here.

Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team (at) simplywallst.com.

This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Join A Paid User Research SessionYoull receive a US$30 Amazon Gift card for 1 hour of your time while helping us build better investing tools for the individual investors like yourself. Sign up here

See original here:
We Think Denbury (NYSE:DEN) Might Have The DNA Of A Multi-Bagger - Yahoo Finance

Posted in DNA | Comments Off on We Think Denbury (NYSE:DEN) Might Have The DNA Of A Multi-Bagger – Yahoo Finance

Page 205«..1020..204205206207..210220..»