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Category Archives: Transhuman News

Woolly mammoth 2.0 could be walking the Earth within 10 years – Genetic Literacy Project

Posted: February 20, 2017 at 6:49 pm

The woolly mammoth vanished from the Earth 4,000 years ago, but now scientists say they are on the brink of resurrecting the ancient beast in a revised form, through an ambitious feat of genetic engineering.

Our aim is to produce a hybrid elephant-mammoth embryo, said Prof George Church, the scientist leading the de-extinction effort. Actually, it would be more like an elephant with a number of mammoth traits. Were not there yet, but it could happen in a couple of years.

Church said that these [genetic] modifications could help preserve the Asian elephant, which is endangered, in an altered form. However, others have raised ethical concerns about the project.

Matthew Cobb, professor of zoology at the University of Manchester, said: The proposed de-extinction of mammoths raises a massive ethical issue the mammoth was not simply a set of genes, it was a social animal, as is the modern Asian elephant. What will happen when the elephant-mammoth hybrid is born? How will it be greeted by elephants?

Church predicts that age-reversal will become a reality within 10 years as a result of the new developments in genetic engineering.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:Woolly mammoth on verge of resurrection, scientists reveal

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New Marshfield Clinic study aims to ID genetic factors linked to severity of blastomycosis illnesses – Wisconsin State Farmer

Posted: at 6:48 pm

Wisconsin State Farmer 10:45 a.m. CT Feb. 20, 2017

Marshfield Clinic Research Foundation(Photo: Supplied)

Marshfield -Marshfield Clinic scientists have launched a new study aimed at determining which genetic factors increase peoples susceptibility to blastomycosis, a deadly fungal infection found throughout central and northern Wisconsin.

The first phase will include recruitment of up to 350 study participants. Anyone previously diagnosed with blastomycosis, or blasto, is encouraged to participate in the study, which could give doctors insight into a mysterious disease that has impacted Wisconsinites for generations.

Were in the heart of blasto country; one significant frustration is we dont know a lot about the disease, said Dr. Holly Frost, study co-investigator and pediatrician at Marshfield Clinic Minocqua Center. If we can find genetic variations that indicate which people respond severely to this disease, it could speed up diagnoses and allow doctors to treat it earlier.

A concern with blasto is the spectrum of severity among patients of all ages and overall health. For instance, the lung infection may spread quickly in a healthy child, resulting in death. Meanwhile, a 70-year-old adult with a compromised immune system may recover quickly.

Thats why its so important researchers unearth any genetic clues that could put doctors closer to understanding blastomycosis, said Jennifer Meece, Ph.D., a Marshfield Clinic Research Foundation (MCRF) scientist and national blasto expert who has studied the disease for more than 10 years.

Scientists know breathing in a naturally occurring fungus often found in moist soil containing rotting plants and wood causes blasto and most infections occur in spring and fall. However, symptoms are similar to other respiratory illnesses, making it difficult to identify early. Also, symptoms dont develop until 3-15 weeks after infection. And while its classified as a rare disease nationally, cases in Wisconsin far exceed the national average.

So much about blastomycosis remains unknown and seemingly random from who is susceptible to what exactly spurs an outbreak but we know the answers are on the horizon, said Meece, co-investigator and director of MCRFs Integrated Research and Development Laboratory. Its enthralling to launch such a study that could impact so many peoples lives.

The study is open to children and adults in Wisconsin, regardless of where they were diagnosed. Study participants do not need to be Marshfield Clinic patients. Due to budget constraints, this first study requires all participants speak English, given no resources for translation.

Participation requires about one hour of clinic time for researchers to gather a sample, explain the study and answer questions. Each participant will receive $25. For more information call 715-221-6445 or email Blastomycosis.study@mcrf.mfldclin.edu.

This study is funded by $150,000 from the Marshfield Clinic Developments Clinician Scientist Research Award.

Marshfield Clinic Research Foundation (MCRF), a division of Marshfield Clinic, was founded in 1959. Its the largest private medical research institute in Wisconsin. MCRF consists of research centers in clinical research, agricultural health and safety, epidemiology, human genetics, and biomedical informatics. Marshfield Clinic investigators publish extensively in peer-reviewed medical and scientific journals addressing a wide range of diseases and other health issues, including cancer, infectious diseases, heart disease, diabetes, eye disease, neurological disease, pediatrics, radiology, women's health, agricultural safety and genetics.

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Human Genetics Contributes To Zika-Induced Brain Damage – MedicalResearch.com (blog)

Posted: at 6:48 pm

MedicalResearch.com Interview with:

Dr. Ping Wu

Ping Wu, MD, PhDJohn S. Dunn Distinguished Chair in Neurological Recovery Professor, Department of Neuroscience & Cell Biology University of Texas Medical Branch Galveston, TX 77555-0620

MedicalResearch.com: What is the background for this study? What are the main findings? Response: Zika viral infection poses a major global public health threat, evidenced by recent outbreaks in America with many cases of microcephaly in newborns and other neurological impairments. A critical knowledge gap in our understanding is the role of host determinants of Zika-mediated fetal malformation. For example, not all infants born to Zika-infected women develop microcephaly, and there is a wide range of Zika-induced brain damage. To begin to fill the gap, we infected brain stem cells that were derived from three human donors, and found that only two of them exhibited severer deficits in nerve cell production along with aberrant alterations in gene expression.

MedicalResearch.com: What should readers take away from your report?

Response: Our study indicates that human genetic makeup may be a determinant for the severity of Zika-induced brain damage.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: Further studies are needed to identitywhat genes contribute to the human differences after Zika infection.

MedicalResearch.com: Is there anything else you would like to add?

Response: It is known that not all Zika virus strains causemicrocephaly. Our study now shows that brain cells from different human individuals can respond to the same Zika virus strain differently.Understanding the molecular mechanisms of human and viral determinants in response to Zika injection will provide important insights into new strategies to minimize ZIKV-mediated fetal brain malformations.

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.

Citation:

Stem Cell Reports:

Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection

Erica L. McGrath10,Shannan L. Rossi10,Junling Gao10,Steven G. Widen,Auston C. Grant,Tiffany J. Dunn,Sasha R. Azar, Christopher M. Roundy,Ying Xiong,Deborah J. Prusak,Bradford D. Loucas,Thomas G. Wood,Yongjia Yu,Ildefonso Fernndez-Salas,Scott C. Weaver,Nikos Vasilakis ,Ping Wu10Co-first author Published Online: February 16, 2017

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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Human Genetics Contributes To Zika-Induced Brain Damage - MedicalResearch.com (blog)

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Bill that allows police to take DNA upon arrest advances – Indianapolis Star

Posted: at 6:48 pm

Damoine A. Wilcoxson, 21(Photo: Provided by Boone County Sheriff's Office)

Two bills that would allow police to takeDNA samples from people who are arrested, but not yet convicted, are steadily advancing but lawmakers have added safeguards for people who may have been falsely accused.

In Indiana, law enforcement officials can only enter DNA samples into a national database upon a felony conviction. But some lawmakers are pushing for a lower threshold, allowing police to takea DNA samplewhen they make a felony arrest.

Bills similar to those proposed this session House Bill 1577 and Senate Bill 322 have failed to generate support in the past, but the issue gained traction last year when DNA from an Ohiodatabase that includes arrestees helped solve boththe slaying of an elderly Zionsville man in November and attacks on two Indianapolis police stations.

The Indiana House of Representativeson Monday opted to send House Bill 1577 to a third reading. The House will likely vote on the bill Tuesday after its final reading.

Rep. Greg Steurerwald, one of the bill's authors, says he "totally expects" the bill will pass the House.

Supporters say taking a DNA sampleupon arrest will expand the database and make it easier for police to solve crimes, as well as clear the name of innocent people. Despite some early concern from some legislatorsabout privacy, the bills have generated bipartisan support, and faced few obstacles thus far.

"It will not only help solve crimes, it will help prevent crimes," Steurerwald told IndyStar.

However, oin Monday, the House approved an amendment that prohibits police from taking a DNA sample during a warrantlessarrest. Rather, police must wait until a judge finds probable cause for the arrest. Lawmakers amended the bill after the issue was raised during a February committee hearing.

"The court must be involved in each of these circumstances," Steurerwald said during the bill's second reading.

A similar bill, authored by Sen. Erin Houchin, is also weaving its way through the Indiana Senate.

In the original Senate bill, a DNA sample could only be expunged from the database if the individual was acquitted of felony charges in a trial. That meant that the DNA sample would remain in the database even if prosecutorsnever filed criminal charges after an arrest, or if charges were dismissed.

But lawmakers have dialed back that measure considerably. Now, an individual can expunge the DNA sample if the case is dismissed, if the felony is reduced to a misdemeanor or if prosecutors do not file charges within a year of the arrest. The House bill includes similar criteria.

Houchin said those changes implemented upon a recommendation from the Indiana State Police lab put the bill in line with similar legislation in other states.

The bill heads to the Senate Appropriations Committee on Thursday where lawmakers will evaluate its cost. Houchin said a study conducted by Indiana University Purdue University-Indianapolis estimated the measure's crime prevention capabilitiescould save taxpayers $60 million a year.

"The savings will help the bill pay for itself,"' Houchin said.

Call Star reporter Madeline Buckley at (317) 444-6083. Follow her on Twitter:@Mabuckley88.

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‘Flood fighting is in our DNA’: To live by the Feather River is to know its power and danger – Los Angeles Times

Posted: at 6:47 pm

The early settlers snatched up the rich, loamy land along the Feather River to grow grapes and orchards.

Edward Mathews, an Irishman who fled the potato famine, was peddling vegetables and didnt have the cash for that kind of soil.

During heavy rains, the Yuba River would flow so hard into the Feather at Marysville, it pushed the Feather back north into Jack Slough, named for a freed slave who in 1861 sold Mathews 200 acres of its poor red soil.

On that backwashed clay, the Mathews clan would scratch out a living grazing livestock.

If you came into the bank with red soil on your boots, they wouldnt loan you money, said Edwards great-grandson Charlie Mathews, 77, who lives on the land today.

But the Mathews family did well for themselves. The arrival of a type of ricefrom Japan that grew in sunlight this far north transformed the cursed clay into a blessing: Water didnt drain through it, giving the ricegrass the pooled paddies it thrived in.

Life in the region has long evolved around the ebb, flow and overflow of the Feather River. Its meandering course and merciless moods dictated where soil was good, which crops farmers grew, where they built towns, how deep they dug wells, where families went broke or dynasties were born.

When California dammed the Feather River as part of its monumental project to bring water to Southern California and other parts of the state, the river became more predictable, but not totally so. Levees blew out in 1986 and 1997 and caused widespread flooding, similar to inundations that hit before the Oroville Dam was finished in 1967.

And the crisis at the dam last week, when more than 100,000 people wereevacuated due to potential failure of an emergency spillway, showed that nature relentlessly works to rip down humanitys efforts to control it. Residents remain anxious as another big storm is expected to hit the area Monday.

Farmers here are keenly aware of one point: They live at the pleasure of the river.

Al Montna remembersthe eerie moonlight glimmer off the tin roofs of houses floating downstream.

Its been more than six decades since the floodwaters hit, but he still pictures it perfectly. They were the homes of his classmates.

He was 10 at the time, living south of Yuba City near the river. His dad was busy trying to move equipment at the farm a few miles away, leaving his wife and kids perched on high ground of the family home.

I heard this roar. I can still hear it, Montna said. It was Christmas Eve 1955.

The flood, caused by a levee break at Shanghai Bend, killed 38 people and destroyed 450 homes. Waters rose to the roofs of low-lying barns.

Seeing the waters surrounding them, Montnas family evacuated to the nearby Sutter Buttes dormant lava domes that loom 2,000 feet above the floodplain like a volcanic beacon for the bedraggled refugees of the valley floor.

His fathers crops were lost and most of the family farm was destroyed. His dad feared financial ruin and died of a heart attack three months later.

Montna lived through two more great floods along the river in 1986 and 1997. But the thought of pulling up stakes never crossed his mind.

Were very ingrained here. My grandfather came here as a French immigrant. ... He drowned in that river, Montna said. This is home. This is part of our soul.

Montna Farms not only recovered but is prospering, he said, specializing in premium, short-grain Japanese rice used in sushi.

When county officials ordered the emergency evacuation of Yuba City last week, many residents again fled to the buttes for safety. Montna took different measures.

As a board member of Levee District 1 of Sutter County, he and his entire work crew scrambled to shore up the levees, looking for leaks that could lead to bigger breaches.

Flood fighting is in our DNA, he said.

A few miles upstream on Feb. 12, Sarb Johl listened in disbelief to the alert that the emergency spillway on Oroville Dam might fail within 60 minutes. He loaded his wife and 92-year-old mother into a car and told them to drive to stay withfamily in the hilly Sacramento suburb of Roseville. He stayed an extra hour talking to other farmers and fellow officials on his levee board, determining what to do.

We didnt have time to rationally plan: Would the water break to the west or the east? Could the levees hold it? You have to believe it when someone is telling you a 15-foot-high wall of water is coming down. That is a lot of water, Johl said.

His father, who came from Punjab, India, began farming peaches and prunes on this reclaimed land in the 1960s. The area is known as Yuba CountyLevee District 10, which was formed in 1909 to make the floodplain available to farmers.

While most orchard growers here dont directly draw from the river, they still survive on it. Because the state water project continued to direct the Feather River water down its historical course, the river replenishes the aquifer as it always has. Johl pumps water from wells and now conserves it by using drip irrigation for his trees, which favor the porous loam slurried down from the mountains over eons.

On Feb. 13, seeing that the spillway had not collapsed, Johl came back to move his equipment onto the levee. On the other side, the silty river sifted slowly through a wild land of oak and cottonwood. A family of deer picked delicately over the bank and into the orchards safety, as one of Johls workers tried to fix a valve in the levee that the farm needed for the land to drain.

His family had survived the last two big floods, but the notion that the dam could fail a nightmare that had never crossed his mind spooked him. As soon as he was done, he got in his truck and headed to Roseville.

***

The Oroville Dam was sold to residents as a flood control measure, but no one who understood water politics ever doubted its core purpose was to bring more water to Southern California. Population studies in the 1950s predicted millions of people would continue toflow into the region with not enough water, even with canals from the Colorado River and Eastern Sierras, to meet their needs.

Plans to dam the stormy rivers of the North Coast the Eel, Mad, Klamath and Smith were scuttled as too costly or controversial. That left the Sacramento Rivers main tributary, the Feather, to become the linchpin of the states ambitious new water project.

The three forks of the Feather gathered snowmelt tributaries from nearly 6,000 square miles of the Northern Sierra and Southern Cascades, converging in the canyons north of the small town of Oroville. The main stem then flowed another 71 miles to the Sacramento River, and on to San Francisco Bay.

Govs. Earl Warren and Goodwin Knight helped get what was then called the Feather River Project rolling in the 1950s, and the deadly 1955 flood gave it a needed dose of urgency. Gov. Pat Brown lobbied groups up and down the state notably the powerful Metropolitan Water District of Southern California, which feared the project might threaten its legal battles with Arizona for Colorado River water to bring it to fruition.

By the time the renamed State Water Project was largely completed in the 1970s, the flow was diverted in the Sacramento Delta before it flowed into the San Francisco Bay. From the Clifton Court Forebay, it was pumped up into the 444-mileCalifornia Aqueduct that would follow the new Interstate 5. With branch canals and massive pumps and siphons to cross hills and mountains, Feather River water now poured out of taps in the Bay Area, Bakersfield, San Luis Obispo, Santa Barbara, Los Angeles and the Inland Empire.

But during rainy winters, the old levee system just below the Oroville Dam still struggled to contain the flow.

In Olivehurst, Mary Jane Griego said the evacuation order brought flashbacks of the floods in 1986 and 1997.

Griego, owner of Dukes Diner,was stopped at a red light outside of Yuba City that night in 1986 when a police patrol car screeched into the intersection.

He saidthe levee broke. The water is coming, Griego recalled. Then she heard a rumble and saw a churning wave of water heading toward her. It was like a scene from The Poseidon Adventure.

That flood blasted through the county mall in the nearby town of Linda, which still stands gutted and empty.

After the 1997 flood, Griego decided to run for Yuba County supervisor, with her top campaign issue to fix the levees in the southern portion of the county. She won and, since that time, the levees have been improved and fortified through the more populated areas.

While farmers and officials along the river understand the hydrology around them like cardiologists know arteries and veins, millions of other Californians rely on the same system with varying degrees of awareness. Some know enough to complain about its great flaws its waste by evaporation or its environmental impact. Others marvel at its grand ambition, allowing great cities to exist where they otherwise could not. Some dont even know it exists.

North of Lake Oroville in the small wooded town of Magalia, Keith Noble runs a hunting and fishing shop that depends on anglers coming to the lake. With the lake closed due to the spillway crisis, he was irked that several bass tournaments had been scrubbed.

Noble thinks the state could have prevented the damage if officials hadnt neglected the spillway all these years in his mind, another example of the northern reaches of California getting short shrift by the big-city liberals controlling Sacramento.

At the southern end of the project, Feather River water pours out of a 28-mile-long pipeline into the Lake Perris reservoir, more than 500 miles from its source and nearly 700 feet higher in elevation.

Saddled between high hills of boulders and white sage, the lake draws campers, boaters and fishermen from across the region. The water teems with rainbow trout, Florida bluegill, black crappie and carp. Anglers there have caught record-size Alabama spotted bass.

But the dam has its own problems. In 2005, the state Department of Water Resources discovered that parts of the foundation might be at risk during an earthquake and ordered the water lowered by 25 feet.Construction to fix the problem is expected to be completed by early next year. But the drought reduced the lake by an additional 17 feet.

Brian Place, manager ofthe boat rental and fishing shop at Lake Perris, looks out at the low water and wonders when the state will open the spigot to bring it back up.

He says Water Resources told him the lake would come up 10 feet in January, but its just starting to fill.

Within the last week, its come up about 3 feet, he said.

He hopes the state sends the water before the fish lay their eggs in spring, and then maintains it at that level, so a sudden change in depth doesnt kill off the spawn.

He can only wait and see.

State bureaucracy feeds Lake Perris, and no meteorologist can read that forecast.

joe.mozingo@latimes.com

Twitter:@joemozingo

phil.willon@latimes.com

Twitter: @philwillon

ALSO

The government failure at the heart of the Oroville Dam crisis

Oroville Dam is about to face its next big test as a new storm moves into the area

Life below Oroville Dam: Stoicism, faith ... and cars poised for a fast getaway

Oroville Dam is just part of California's crumbling infrastructure

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'Flood fighting is in our DNA': To live by the Feather River is to know its power and danger - Los Angeles Times

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ACLU sues San Diego police over how it collects DNA from juveniles – The San Diego Union-Tribune

Posted: at 6:47 pm

A blackteenager who was stopped by police last year while walking through a San Diego park is challenging the Police Departments policies and practices for obtainingDNA from minors without first notifying a parent.

Lawyers from the American Civil Liberties Union of San Diego & Imperial Counties filed a federal lawsuit last week on behalf of the boy and his mother, Jamie Wilson.They contend police officers violated the boys civil rights in March when they detained, handcuffed and searched him at Memorial Community Park in Logan Heights, and then took a sample of his DNA without a warrant or his mothers consent.

According to the complaint, San Diego Police Department policy allows officers to obtainconsent from a minor for DNA collection the same way they would for an adult.

California law restricts the collection of DNA from a juvenile for inclusion in Californias DNA database, but the lawsuit says San Diego has sidestepped that by maintaining its own local database. Officers are required to notify a juveniles parents only after a DNA sample has been taken.

San Diegos policy systematically works to circumventparents right to advise their kids, saidJonathan Markovitz, one of the attorneys representing Wilson and her son.

A Police Department spokesman declined to comment about the lawsuit but provided a copy of the agencys procedures for dealing with juveniles. The document states that a minors DNA can be taken and stored in the departments own data bank if obtained legally and for investigative purposes.

We have just been made aware of the lawsuit filed by the ACLU.This case is pending litigation we therefore cannot comment further, police Lt.Scott Wahl said in an email.

The plaintiffs are seeking a permanentinjunction from the court that would forbid the San Diego Police Department from enforcing the citys policy on DNA collection from juveniles without a warrant or parental consent. They are also asking for an order compelling the Police Department to return any DNA samples from the teen identified in the lawsuit.

They also are seeking unspecified monetary damages.

According to the lawsuit, police officers chose to conduct a pat-down search of the 16-year-old boy identified in the document by the initials P.D. and four of his friends not because there was a reasonable suspicion they had been involved in a crime, but because they were black juveniles, some of whom were wearing blue, walking through a park in southeast San Diego on a particular day.

The officers expectedgang activity in the park that day, March 30, a supposed gang holiday, the lawsuit said. Blue is a color associated with a particular street gang.

P.D. and the other minors told the officers they had been playing basketball in the area.

After the pat-down search, the officerssearched a duffel bag P.D. had with him that afternoon and found an unloaded handgun. They collected DNA samples from him and his four companionsafter obtaining their signed consent.

The friends were released and P.D. was booked into Juvenile Hall.

The difficulty with kids giving consent is that they are particularly vulnerable to authority,Markovitz said, noting that children and teens are less likely to think through the consequences of their actions a concept state and federal laws have acknowledged.

Hesaid the search of the teensduffel bag was unlawful and any consent the teen had given for the taking of his DNA sample was essentially coerced, given that the officers let his friends go after they each signed a form agreeing to let the officers swab the inside of their mouths to collect DNA.

There wasnt anything approaching knowing and voluntary consent. ... He wasnt given the opportunity to talk to his mother,Markovitz said.

Per department procedure,a San Diego policeofficer has to notify a supervisor or contact a field lieutenant for approval before collecting a mouth swab DNA sample from a juvenile. The office must also fill out a Consent to Collect Saliva form and obtain the minors signature.

An officer who takes a mouth swab sample from a juvenile will notify the parent or legal guardian that a sample was taken and document that information on a report,according to the department.

According to the lawsuit, the District Attorneys Office filed charges in Juvenile Court against P.D. on April 4, stemming from the discovery of the gun in the duffel bag. He remained inJuvenile Hall until April 8, when he was released and placed on home supervision.

On June 27, a judge threw out the evidence related to the gun because it was fruit of an unlawful search that violated P.D.s Fourth Amendment rights, under the U.S. Constitution. A month later, the court dismissed the charges but no order was made to destroy the teens DNA sample.

Its caused tremendous emotional and financial suffering, Markovitz said, referring to the effects of the arrest and subsequent court proceedings on the teen and his family.

Hismother is expected to appearat a news conference Wednesday, when ACLU representatives will discuss the lawsuit and issues related to local policing.

dana.littlefield@sduniontribune.com

Twitter: @danalittlefield

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Screening of kin of breast cancer victims vital, says genome expert – The Hindu

Posted: at 6:47 pm

Every woman who had ovarian or breast cancer with the BRCA1 and BRCA2 mutation, and was detected after her diagnosis, is a missed opportunity to prevent a cancer. No sister or daughter of a person with such a mutation should die of breast or ovarian cancer, it doesnt have to happen; it is completely preventable, Mary-Claire King, Professor of Genome Sciences at the University of Washington, said here on Monday. In a sense, it all began with Prof. King after she identified the mutation in the BRCA1 gene that causes breast cancer.

Genetic testing is crucial for prevention, treatment, and families, Prof. King underlined throughout her lecture on Understanding Inherited Breast and Ovarian Cancer: From Gene Discovery to Precision Medicine and Public Health. Prof. King was in Chennai for the first Cell Press-TNQ India distinguished Lectureship Series, 2017. She will be speaking in three other cities: Bengaluru on Wednesday, New Delhi on Friday, and Kolkata, the following Tuesday.

Prof. King also had a proposition for India to undertake to test genetically every breast and ovarian cancer patient for the BRCA1 and BRCA2 and all other known breast and ovarian cancer genes. The yield in testing of patients will probably be 18 per cent of ovarian cancer patients who have a mutation in one of these genes and about 10-15 per cent of breast cancer patients who do, with a higher proportion of younger women.

Informed choice

She went on to add that it was important because a patient who finds that she has a mutation can decide whether to remove her ovaries and fallopian tubes in her late 30s or 40s so that she does not get breast cancer; that her sisters and daughters can be aware that they should undergo genetic testing ideally. If they are resistant to that, then they can be subject to surveillance, at least. The sister or daughter of a patient with such mutations has a 50-50 chance of acquiring a mutation herself, the geneticist said.

The costs for such testing have come down drastically, Prof. King said. The cost is much less, even lower than it was a year ago. For instance, in the [United] States, in Indian terms, it costs about Rs. 15,000 to test all the genes all at once. It used to be 20 times that just a couple of years ago. She also touched upon the new Broca Gene Panel available now, that runs a single blood sample through tests for all known classes of mutation that cause breast and ovarian cancer.

Prof. King came back many times during her lecture to the role of menarche in breast cancer. When menarche occurs at a younger age, good epidemiological evidence suggests that the interval between menarche and child birth has a direct relationship with the risk of breast cancer. As the interval increases, the risk also increases, she explained.

Generational change

One study showed that women born before 1958, have, a lower risk of developing breast or ovarian cancer, than say, women born after 1958. This cannot be genetics. This difference is, I think, the same reasons that we see a rapid increase in incidence of breast cancer. Between these generations, there was change in womens lives.

Of course, plenty of women who do not carry the mutation, have the disease too. Some of the women actually have inherited the mutation from the father and not the mother. Their decision to go in for prophylactic surgeries removal of the ovaries and fallopian tubes, and/or double mastectomies depends on their personal experience. Most women who go in for surgery have watched a mother or sister die of breast or ovarian cancer, Prof. King explained.

N. Ram, chairman, Kasturi and Sons, introduced the speaker, while Mariam Ram, MD, TNQ Books and Journals, spoke of the lecture series through the years.

Emilie Marcus, CEO, Cell Press, announced the names of the finalists of the Inspiring Science awards: Balaji Banoth, Vijay Soni, Richa Pahuja, Abhishek Trivedi, Pankaj Kumar Dubey, and Ramya Purkanti.

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Screening of kin of breast cancer victims vital, says genome expert - The Hindu

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‘Feeding Your Genome’ Conference Scheduled at UA – UANews (press release)

Posted: at 6:47 pm


UANews (press release)
'Feeding Your Genome' Conference Scheduled at UA
UANews (press release)
To that end, the Department of Nutritional Sciences, part of the College of Agriculture and Life Sciences, will host the "Feeding Your Genome: Precision Nutrition and Health" conference Feb. 22-24 at the UA. The conference agenda, with event locations, ...

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'Feeding Your Genome' Conference Scheduled at UA - UANews (press release)

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The USA Just Approved HUMAN Embryo Genome Modification Research Paving the Way For Designer Babies – The Christian Truther

Posted: at 6:47 pm

Sometime very soon the first humans to be genetically edited will be born, and the United States just paved the way.

In December 2015, scientists and ethicists at an international meeting held at the NAS in Washington said it would be irresponsible to use gene editing technology in human embryos for therapeutic purposes, such as to correct genetic diseases, until safety and efficacy issues are resolved.

On February 14th, 2017; the National Academy of Sciences and the National Academy of Medicine issued a report outlining the permissible circumstances upon which the research into editing human embryos could be conducted.

Their latest statement signals that the NASis softening its approach, to the use of gene-editing technology such as CRISPR-CAS9.

Previously genome editing was already being planned for use in clinical trials on people to correct diseases. However, the primary concern is over the utilization of the technology in human reproductive cells or early embryos because the changes would be passed along to offspring.

Although gene editing of human reproductive cells to correct inherited diseases must be approached with caution, caution does not mean prohibition, the committee said in a statement.

The rise in genome editing signals the real end of the human being. Simply put, directly after the first genome alteration and birth, the natural genome would be something entirely man-made.

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The USA Just Approved HUMAN Embryo Genome Modification Research Paving the Way For Designer Babies - The Christian Truther

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Genome Editing Has Begun How Will It Be Controlled? | Big Think – Big Think

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CRISPR-Cas9 is a precise method of gene editing. It can snip a gene out of the DNA sequence say, a harmful mutation then add a healthy gene to replace it. This new but exciting technique is being used in clinical trials to treat things like hereditary cancer. It could also be a godsend for certain genetic diseases, such as Huntingtons or Tay-Sachs disease, among others. Experimental studies with cancer and blindness are slated to reap benefits this year.

Despite the great promise this new technique affords, there is controversy surrounding applying it to human embryos. One such concern is creating designer babies. Another is accidentally creating a hereditary disease and allowing it to enter the human genome. This could be passed down from parent to child, dooming future generations. But some fear that stifling regulation suppresses innovation and the march of progress. So, of course, there needs to be balance between regulation and freedom of exploration.

The National Academy of Sciences (NAS), aware of the growing debate, put together a committee of experts last year to consider the ethical quandaries the technique presents when applied to human embryos. It's just recently released its report, a full 261 pages, which suggests allowing CRISPR to be performed on embryos in certain instances, and barring others. The committee concluded that cures for serious diseases and disabilities should be allowed, especially when conventional medicine offers no reasonable alternative. But the advisory panel wont abide designer babies or the creation of super soldiers.

The committee suggests opening the door a crack, and allowing gene editing on embryos for research on certain diseases.

Richard Hynes co-chaired the committee. He wrote that since the science is flying by at an outrageous clip, we should keep a tight grasp on it for now. You want to have a good control of what is being done, he wrote. Chinese scientists have already modified the DNA of five embryos as of 2015, using this technique. Sweden is also conducting advanced experiments, fueling the fear that the US could fall behind.

Many hailed the NAS committees move. This framework should allow for more cancer studies and those on genetic diseases, like retinal degeneration, which can lead to blindness. But some say, the guidelines are still too stringent. There are a lot of genetic diseases such as muscular dystrophy, sickle cell anemia, or even Parkinsons, which may benefit from CRISPR experiments. But the panel fears allowing a technique whose outcome isnt entirely known.

University of Wisconsin ethicist Alta Charo was a co-chair of the advisory group. She said that although off-label uses, or those which a drug wasnt intended for, are tolerated with pharmaceuticals commonly, gene editing of embryos would not allow such a practice. Whats more, a social consensus is needed before the gene editing of embryos becomes common practice. It is essential for public discussions to precede any decisions about whether or how to pursue clinical trials of such applications, said Charo. And we need to have them now.

Some fear that this technique could someday be used to add muscle tissue to a persons body to make them stronger or faster, or neural manipulation will be performed to reap greater intelligence. Gene editing may even allow for certain anti-aging features to become available. This last one might be allowed as a sort of preventative medicine.

With these guidelines, Charo and colleagues were clear: you can use gene editing to undo illness but not enhance the human body. Some geneticists find the prospect of genetic enhancement ethically inviolable. Even so, the technique is not able to perform such feats, yet. Genome editing to enhance traits or abilities beyond ordinary health raises concerns about whether the benefits can outweigh the risks, and about fairness if available only to some people," Charo said.

This research could create a backlash. Committee members point out the need for a societal consensus on the gene editing of embryos, before it becomes commonplace.

Should we continue to embrace individuality, or are we destined to edit out everything that makes us unique, creating a race of beautiful, bland, healthy geniuses, and in the end, losing heterogeneity? With it could go innovation, novelty, uniqueness, disruption, and creativity. After all, it is usually the mavericks, the marginalized, and the outliers that revolutionize society. Or would a startling divide be born, between those who could afford gene editing and those who couldnt?

The philosopher Alan Watts once said that if we reached the point where we could design people, we should make as diverse a group of possible, so to have enormous flexibility. For who knows what kinds of people will best populate the late 21st century and beyond.

These guidelines posit a tight way of allowing the exploration of CRISPR for use in the human genome. Currently, the FDA bars the germline engineering, or gene editing, of human offspring. But the guidelines are meant as a crack of light, showing the way, but also a way of beginning the conversation of how we should proceed.

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Genome Editing Has Begun How Will It Be Controlled? | Big Think - Big Think

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