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Category Archives: Transhuman News

DNA acts like electrical wire to replicate itself – Futurity: Research News

Posted: February 28, 2017 at 7:46 pm

DNAs ability to act like an electrical wire plays a part in how it replicates,new research shows.

In the early 1990s, Jacqueline Barton, professor of chemistry at Caltech, discovered an unexpected property of DNAthat it can act like an electrical wire to transfer electrons quickly across long distances. Later, she and colleagues showed that cells take advantage of this trait to help locate and repair potentially harmful mutations to DNA.

Now, Bartons lab has shown that this wire-like property of DNA is also involved in a different critical cellular function. When cells divide and replicate themselves in our bodiesfor example in the brain, heart, bone marrow, and fingernailsthe double-stranded helix of DNA is copied. DNA also copies itself in reproductive cells that are passed on to progeny.

The new study, based on work by graduate student Elizabeth OBrien in collaboration with Walter Chazins group at Vanderbilt University, offers evidencethat a key protein required for replicating DNA depends on electrons traveling through DNA.

Nature is the best chemist and knows exactly how to take advantage of DNA electron-transport chemistry, says Barton.

The electron transfer process in DNA occurs very quickly, says OBrien, lead author of the study in Science. It makes sense that the cell would utilize this quick-acting pathway to regulate DNA replication, which necessarily is a very rapid process.

The researchers found their first clue that DNA replication might involve the transport of electrons through the double helix by taking a closer look at the proteins involved. Two of the main players in DNA replication, critical at the start of the process, are the proteins DNA primase and DNA polymerase alpha. DNA primase typically binds to single-stranded, uncoiled DNA to begin the replication process. It creates a primer made of RNA to help DNA polymerase alpha start its job of copying the single strand of DNA to create a new segment of double-helical DNA.

DNA primase and DNA polymerase alpha molecules both contain iron-sulfur clusters. Barton and her colleagues previously discovered that these metal clusters are crucial for DNA electron transport in DNA repair. In DNA repair, specific proteins send electrons down the double helix to other DNA-bound repair proteins as a way to test the line, so to speak, and make sure there are no mutations in the DNA. If there are mutations, the line is essentially broken, alerting the cell that mutations are in need of repair. The iron-sulfur clusters in the DNA repair proteins are responsible for donating and accepting traveling electrons.

Barton and her group wanted to know if the iron-sulfur clusters were doing something similar in the DNA-replication proteins.

We knew the iron-sulfur clusters must be doing something in the DNA-replication proteins, otherwise why would they be there? Iron can damage the DNA, so nature would not have wanted the iron there were it not for a good reason, says Barton.

Through a series of tests in which mutations were introduced into the DNA primase protein, the researchers showed that this protein needs to be in an oxidized statewhich means it has lost electronsto bind tightly to DNA and participate in DNA electron transport. When the protein is reducedmeaning it has gained electronsit does not bind tightly to DNA.

The electronic state of the iron-sulfur cluster in DNA primase acts like an on/off switch to initiate DNA replication, says OBrien.

Whats more, the researchers demonstrated that electron transport through DNA plays a role in signaling DNA primase to leave the DNA strand. (Though DNA primase must bind to single-stranded DNA to kick off replication, the process cannot begin in earnest until the protein pops back off the strand).

The scientists propose that the DNA polymerase alpha protein, which sits on the double helix strand, sends electrons down the strand to DNA primase. DNA primase accepts the electrons, becomes reduced, and lets go of the DNA. This donation and acceptance of electrons is done with the help of the iron-sulfur clusters.

You have to get the DNA primase off the DNA quicklythat really starts the whole replication process, says Barton. Its a hand off of electrons from one cluster to the other through the DNA double helix.

Many proteins involved in DNA reactions also contain iron-sulfur clusters and may also play roles in DNA electron transport chemistry, Barton says. What began as a fundamental question 25 years ago about whether DNA could support migration of electrons continues to lead to new questions about the chemical workings of cells. Thats the wonder of basic research, she says. You start with one question and the answer leads you to new questions and new areas.

Funding for the work came from the National Institutes of Health.

Source: Caltech

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Taming traits from the wild genome – Good Fruit Grower

Posted: at 7:45 pm

The second generation of apple trees bred with resistance to blue mold from a wild ancestor are growing in the U.S. Department of Agricultures Appalachian Fruit Research Laboratory in Kearneysville, West Virginia. DNA tests developed through RosBREED and apples genetically engineered to flower early are helping researchers introduce the disease resistance into high-quality cultivars faster. (Courtesy Jay Norelli, USDA Appalachian Fruit Research Laboratory)

Over generations, as breeders have selected apple trees with the best flavor, size and color, resistance to many common diseases was lost.

But genes for resistance are often still lurking in wild apple ancestors, and new DNA tools are giving breeders the power to return those key genes to domestic apple varieties in a matter of years, not decades.

In the case of blue mold the most significant postharvest disorder globally scientists found resistance hiding in the genome of Malus sieversii, the wild Eurasian apple from which the domestic species was derived. Now, researchers with the U.S. Department of Agricultures Appalachian Fruit Research Station in Kearneysville, West Virginia, are breeding that wild resistance back into an elite breeding parent.

New tools are helping them to do it fast: Cultivars are expected to be ready for breeders in just a few more years, said Jay Norelli, the plant pathologist leading the project. We are tapping into the latest advantages that have been made in genomics science to really advance the efficiency of apple breeding, Norelli said.

But while some of the tools used to expedite breeding are the result of genetic engineering, Norelli stressed that the process is not creating genetically modified apples.

The final, blue-mold resistant cultivar will have no genetically modified DNA. Thats very important to growers because some consumers have been wary of genetically modified crops, he said.

All the genomics tools are available thanks to RosBREED a national team of scientists seeking to improve the quality and disease resistance of apple, blackberry, peach, pear, rose, strawberry and sweet and tart cherry crops and to a sister effort in Europe known as FruitBreedomics.

The American project was funded by the U.S. Department of Agriculture first in 2009 with a $14 million grant to look at fruit quality traits, then re-upped in 2015 for a $10 million focus on disease resistance.

From the start, RosBREED has been clear that it was not seeking to genetically engineer better crops, but rather to use DNA analysis tools to inform and improve conventional crossbreeding, said Cameron Peace, RosBREED co-director and horticulture professor at Washington State University.

Every generation, Norelli sends samples from his new seedlings to Peaces lab at WSU, where RosBREEDs DNA-informed breeding programs for apple and cherries are based.

The lab focuses on translating discoveries from genomics research into strategies breeders can use, Peace said.

So far, his lab is developing DNA markers for disease resistance, fruit color, acidity levels and other desirable traits so that breeders can test and select seedlings without waiting for fruit.

That saves breeders the expense and time of growing a nursery full of trees that lack the desired genes in search of the perfect fruit. Eventually, RosBREED aims to help commercial service providers offer the tests it develops to breeders, expanding access to the tools, Peace said.

One-year-old apple trees are fruiting, thanks to an early-flowering gene that accelerates the crossbreeding process. These trees are the second generation of a cross to bring blue mold resistance from a wild apple ancestor into a modern cultivar. This fruit will be exposed to blue mold to verify that the DNA test scientists are using in the breeding program is accurate. (Courtesy Jay Norelli, USDA Appalachian Fruit Research Laboratory)

The challenge for breeders is that the wild ancestors carrying resistance also come with lots of undesirable traits that have been bred out of modern apples.

Keeping only the key resistance gene traditionally required four or five decades of back-crossing with high-quality cultivars to get rid of that wild DNA. Now, DNA-markers and genetically engineered tools have dramatically improved the pace.

Locating the blue mold resistance marker involved developing a genetic map of a cross between the resistant wild apple and a Royal Gala.

Then scientists compared the DNA of all the offspring to find the DNA associated with the resistance trait. In the case of blue mold, there was one clear spot on one of the apples 17 chromosomes associated with resistance.

That key finding enabled the research to move forward much more quickly and is much easier to work with than a trait that appears to be associated with multiple genes, Norelli said.

Once that locus a location on a chromosome was identified, WSU researchers built a DNA test to assess which seedlings inherited the resistance gene.

The growing library of DNA tests means that Norellis seedlings can also be screened for about 10 other desirable traits, such as acidity and skin color, Peace said.

In traditional breeding efforts combining two already high-quality cultivars, fewer DNA tests are usually needed, but theres a lot more bad genetics in this material from the wild apple, Peace said. Using all the tests on each generation of seedlings helps to weed out those unwanted wild genes faster.

Before DNA tests, breeders measured disease resistance by purposely infecting new trees. But having access to the genetic markers is a huge advantage, especially for a disease like blue mold, which causes fruit decay during storage rather than damages the tree itself.

For a lot of diseases like scab and fire blight, we can screen seedlings directly with the pathogens, but DNA tests are better. And one of the big advantages of DNA markers for fruit traits is it saves us years versus waiting for apples, Norelli said.

To speed up the breeding process even further, Norelli is using a genetically modified apple that carries a gene from a birch tree that initiates early flowering. By using it as a parent, his trees are blooming and ready to breed at just over a year old, instead of having to wait three years for each generation to flower.

That transgene for early flowering was introduced into the Pinata cultivar by German researchers, who used it in a similar way to breed fire blight resistance into modern cultivars as part of the FruitBreedomics project.

The early flowering trait comes from a single, dominant gene, which means that every generation, half the seedlings produced are early flowering; the other half flower normally because they did not inherit the chromosome with the transgene.

To accelerate this breeding process, Norelli crossed the parents the offspring of the wild apple and the Royal Gala and the Pinata cultivar containing the birch tree gene in the conventional manner and selected offspring with both the resistance gene and the early flowering gene. Now, he is continuing to cross those offspring for several more generations to weed out unwanted wild apple genes.

Once that breeding process creates high-quality, blue mold resistant cultivars, Norelli will no longer need the early flowering gene. So in the final round of the breeding process, he will select offspring that dont carry the transgenic gene from the birch tree and thus are not considered genetically modified to grow into normal apple trees.

The second generation of blue-mold resistant, early flowering apple trees are growing in the U.S. Department of Agriculture greenhouse in West Virginia. Some of the spindly trees are already fruiting. But even high-tech tools need to be proven in the nursery. So, Norelli is preparing to test the DNA-based breeding by exposing the first crop of fruit to the blue mold fungus, so he can evaluate how susceptible they really are.

We are validating whether that test actually predicts resistance. Thats really important because before we at RosBREED release a tool, we test it so breeders can use it with confidence, Norelli said.

If the test proves itself, as scientists suspect, the cultivar should be ready for breeders by 2019. There are a few more crosses to go, Norelli said, to maximize the domestic apple genes and minimize the wild genes. To meet that deadline, the team is employing one more novel genetic tool that helps to select seedlings with the least wild DNA.

Every new generation has a mix of its parents traits typically 50-50 but due to some genetic rearranging that happens as chromosomes are passed on, theres always a little variation.

By the third generation, about 25 percent of the genetics should be M. seversii, but because of crossing over of the chromosomes, some have less and some have more, Norelli said. Were using a DNA test to track how much wild DNA is left.

FruitBreedomics developed the test to track apples lineage by looking at about 20,000 loci. Thats far from sequencing the entire genome, but it provides a significant snapshot of an apples 17 chromosomes.

After the test is run on each parent the wild apple, Royal Gala, and Pinata with the early flowering gene the offspring can be compared to see how much they still resemble the wild apple. With that insight, Norelli can beat the 50-50 odds slightly with each cross and select those seedlings with both the key traits and the least wild DNA to give rise to his next generation.

With the accelerated system, that should be a one- to two-year window to get that next generation, he said. Our first objective is to produce elite breeding parents with resistance alleles and then trying to incorporate other resistance alleles for fire blight and scab.

by Kate Prengaman

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The Human Microbiome: Advancing New Frontiers in a Rapidly … – Yahoo Finance

Posted: at 7:45 pm

LONDON, Feb. 28, 2017 /PRNewswire/ -- of Human Microbiome research and development is apparently one of the most popular hubs of the biotechnology industry. While the Human Microbiome Project, MetaHIT and other huge studies of human microbiota, have garnered a lot of attention over that past few years, the microbiome space has literally exploded in terms of both basic and applied biomedical research.

Download the full report: https://www.reportbuyer.com/product/3599059/

This report focuses on biomedical aspects of research, development, and commercial endeavors in the human microbiome space. It includes essential background information, evolution of the field, advances in basic research, events in the emerging commercial market, deal activity, interviews with experts, and trends in microbiome research and commerce. Primary sources of information for this report include the scientific literature, discussions with experts, and an online survey of individuals working in this space.

This Report Covers:Advances in Research on the Human Microbiome Commercial Aspects of Microbiome Research and Development Current Deal Activity Over 25 Companies Profiled Survey data from exclusive Insight Pharma Reports Survey

Interviews with:Lee Jones, Founder CEO, Rebiotix Brian Varnum, PhD, Chief Development Officer C3 Jian Yanjiao Zhou, MD, PhD, Research Scientist, The Jackson Laboratory for Genomic Medicine Dr Bernard Malfroy-Camine, President and CEO, ViThera Pharmaceuticals Mark L. Heiman, Ph.D., FTOS, Vice President, Research and CSO, MicroBiome Therapeutics (formerly NuMe Health) Larry Weiss, MD, Chief Medical Officer, AOBiome, LLC Karen E. Nelson, PhD, President, J. Craig Venter Institute (JCVI), Head, Microbiome Program, Human Longevity Institute (HLI) Sara Malcus, PhD, CEO, MetaboGen AB

Download the full report: https://www.reportbuyer.com/product/3599059/

About Reportbuyer Reportbuyer is a leading industry intelligence solution that provides all market research reports from top publishers http://www.reportbuyer.com

For more information: Sarah Smith Research Advisor at Reportbuyer.com Email: query@reportbuyer.com Tel: +44 208 816 85 48 Website: http://www.reportbuyer.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/the-human-microbiome-advancing-new-frontiers-in-a-rapidly-emerging-market-300415250.html

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Fitness blogger praised for sharing makeup-free photo after eczema flareup – Fox News

Posted: at 7:45 pm

Everyone has bad days. But usually online, we only see peoples good ones.

However, we all know thats not reality and thats precisely the inspiring message from Carys Gray, a fitness blogger whos being praised after sharing an honest makeup-free photo of herself during an eczema flareup.

MODEL'S AMAZING JOURNEY FROM PREGNANT TO 6-PACK

Gray, who has more than 148,000 followers on the social media platform, shows two photos of herself in the viral image: one with her eczema under control and makeup on her face, and another with her eczema flared up and her face makeup-free.

Social media/Instagram will show the good days, Gray wrote in part in the now viral post, which had garnered over 80,000 likes as of Tueday afternoon. But here's a reminder that next time you see something on social media that you think is 'goals' that it's not the full story, it's not how that person will look or be alllllll the time!

Eczema, or atopic dermatitis, is a chronic skin condition that causes redness and itchiness, according to the Mayo Clinic. It can occur at any age, and it does not have a cure.

THIS FIT MOM DROPPED 6 DRESS SIZES BY LOSING ONLY 2 POUNDS

In the caption of the post, Gray goes on to encourage her followers to have body confidence despite their imperfections.

I'm still struggling to accept myself on the right, it's a big insecurity of mine and that's fine, she wrote. I'm learning to accept myself knowing that everyone has their own struggles and insecurities and that's what makes us unique and special.

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Women’s stress levels before pregnancy could influence risk of … – Medical Xpress

Posted: at 7:45 pm

February 28, 2017 Womens stress levels before pregnancy could influence risk of eczema in child. Credit: University of Southampton

Infants whose mothers who felt stressed before they fell pregnant had a higher risk of eczema at age 12 months, new Southampton research has shown.

The study from the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, is the first to link preconception maternal stress to the risk of atopic eczema in the child.

The researchers believe the findings support the concept that eczema partly originates as a baby develops in the womb and could reveal ways of reducing the risk of the skin condition.

The research, published in Clinical and Experimental Allergy, assessed the stress levels of women recruited to the Southampton Women's Survey before they were pregnant. They were asked to report how stressed they were in their daily lives. A sub-group were asked about their psychological wellbeing.

Around 3,000 babies born into the Survey were then assessed for eczema at ages six and 12 months.

Dr Sarah El-Heis, the study's lead researcher from the University of Southampton, comments: "We know that maternal stress can release certain hormones that can have an effect on the baby's immune response, leading to an increased risk in conditions like eczema.

"More than one in six women of the mothers in the Southampton Women's Survey reported that stress affected their health 'quite a lot' or 'extremely' our analyses showed that their infants had a 20% higher likelihood of developing atopic eczema at age 12 months when compared with the remainder of the study cohort. The findings also showed that stress and low mood experienced closer to the time of conception may have a greater impact on the risk offspring atopic eczema."

The research showed similar findings of an increased risk of infant eczema for the women who reported psychological distress before they became pregnant. The associations were robust to adjustment for other influences, including a history of eczema in the mother, smoking during pregnancy and infant gestational age, sex and breastfeeding duration.

Professor Keith Godfrey, Director of the NIHR Southampton Biomedical Research Centre in Nutrition, added: "Previous research has linked low maternal mood after delivery with an increased risk of eczema in the infant, but the new research showed no association between postnatal mood and eczema after taking account of preconception stress. More research is needed to investigate this interesting association, but the findings are further evidence of the influence preconception maternal health and wellbeing has on infants."

Explore further: Vitamin B levels during pregnancy linked to eczema risk in child

Infants whose mothers had a higher level of a particular type of vitamin B during pregnancy have a lower risk of eczema at age 12 months, new Southampton research has shown.

(HealthDay)People dealing with the itchy skin condition known as eczema may have other medical conditions to cope with as well, including heart disease, a dermatologist says.

(HealthDay)Atopic dermatitis (AD) is most commonly referred to as AD in the literature, according to a review published online July 8 in Allergy.

A*STAR researchers have shown that eczema has different risk factors depending on its age of onset, after evaluating more than 1,000 Asian newborns over in an 18-month study.

(HealthDay)Self- and caregiver-reported history of eczema is valid for identifying atopic dermatitis (AD), according to a study published online July 17 in the British Journal of Dermatology.

Children with eczema have a more diverse set of bacteria in their guts than non affected children, finds a new study in BioMed Central's open access journal BMC Microbiology. The types of bacteria present were also more typical ...

Researchers at Cardiff University have discovered that genetic variation is the reason why some immune systems overreact to viruses.

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new regulator of the innate immune responsethe immediate, natural immune response to foreign invaders. The study, published recently ...

A new discovery by researchers at the Fred Hutchinson Cancer Research Center in Seattle makes an important step in identifying which specific T cells within the diverse army of a person's immune system are best suited to ...

As much as we try to avoid it, we are constantly sharing germs with those around us. But even when two people have the same infection, the resulting illnesses can be dramatically differentmild for one person, severe or ...

Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseases as a possible treatment with fewer risks and lower costs than current therapies.

If you've ever wondered how a vaccine given decades ago can still protect against infection, you have your plasma cells to thank. Plasma cells are long-lived B cells that reside in the bone marrow and churn out antibodies ...

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Scientists Are Making Personalised Eczema Treatments From People’s Own Microbes – ScienceAlert

Posted: at 7:45 pm

Cultivating 'friendly' bacteria from people's skin makes it possible to develop personalised lotions to treat skin conditions like eczema, a new study shows.

It's the latest evidence that beneficial bacteria in our microbiome can be used to treat infections spurred by harmful microbes, and could provide a new direction in antibiotics research: something we desperately need, in light of rising antimicrobial resistance.

While everybody's skin is populated with a mixture of healthy and harmful bacteria, the ratio of good to bad isn't always the same. This imbalance could help to explain why some people have conditions like atopic dermatitis (AD) the most common form of eczema, which produces inflamed and irritated skin, and affects almost 18 million Americans.

"People with this type of eczema, for some reason that's not quite known yet, have a lot of bacteria on the skin, but it's the wrong type of bacteria," dermatologist Richard Gallo from UC San Diego told the Associated Press.

"They're not producing the antimicrobials they need."

To find out about the makeup of these bacteria populations, Gallo and his team examined skin culture swabs taken from 30 healthy people and 49 subjects with AD.

After screening thousands of colonies of bacteria, they found that the skin of healthy people is rich in two bacterial species Staphylococcus hominis and Staphylococcus epidermis. Both of these are known to defend against a harmful kind of bacterium called Staphylococcus aureus aka Golden Staph, the precursor to the deadly superbug MRSA.

Dermatologists don't know if Staph actually causes AD, but it's been shown that the bacteria can help promote AD symptoms with studies going back as far as the 1990s demonstrating that the density ofS. aureus colonies corrolates with the inflammation and severity of eczema.

In Gallo's research, the team found that people with AD don't exhibit large populations of S. hominis and S. epidermis, while S. aureus was found to abundant.

To see if it would be possible to give people with low levels of these beneficial bacteria a boost, the researchers ran another experiment, isolating S. hominis and S. epidermis cultures from five participants with AD.

After isolating strains that counter S. aureus thanks to the production of proteins called antimicrobial peptides (AMPs), the team grew more of these bacteria in the lab.

Once they'd boosted the population counts of these healthy bacteria, the researchers mixed them into a moisturiser, giving each participant a personalised skin lotion sourced from their own microbiome.

Applying the lotion to participants' arms to give them about the same amount of beneficial bacteria as the healthy participants about 100,000 colony-forming units per square centimetre of skin saw S. aureus disappear completely in two patients within just 24 hours, while dropping significantly in the three others.

The researchers haven't announced if the physical symptoms of AD eased up in addition to the S. aureus count being reduced, but they are confident that they've found the basis of a working treatment here.

"We now have a rational therapeutic approach for atopic dermatitis by using bacterial transplant technology," Gallo said in a press release.

"It appears that people with this disorder will need to have it reapplied because their body does not naturally promote the growth of these organisms. The good thing is this is easy to do because it's just a cream."

Better still, compared with broad-spectrum antibiotics that kill a wide range of bacteria both good and bad the researchers' technique enables them to cultivate strains that only target harmful bugs.

"[Antibiotics] not only target S. aureus, but also kill beneficial bacteria," Gallo told Ed Yong at The Atlantic. "Our approach identified antimicrobials that have evolved to kill S. aureus while leaving the good bacteria alone."

We should keep in mind that this is a very small study so far, with the lotion just having been tested on five participants for a short period of time the participants only applied the cream once, with the results being checked 24 hours later.

But there are reasons to be optimistic, with the team now conducting a much larger clinical study, involving 60 patients using personalised lotions for longer periods up to weeks and months in duration to see how treatments pan out in the long term.

Until we hear those findings, we shouldn't get too carried away about the results of this study, but hopefully there's more good news to report on this in the future.

"It's a big step towards using microbial therapies to treat skin disease," immunologist Shruti Naik from Rockerfeller University, who wasn't involved with the study, told The Atlantic.

"It will be interesting to take it a step further, and test if the beneficial microbes can dampen or cure eczema."

The findings are reported in Science Translational Medicine.

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Evaluation of psoriasis patients’ attitudes toward benefitrisk and therapeutic trade-offs in their choice of treatments – Dove Medical Press

Posted: at 7:44 pm

Lina Eliasson,1 Anthony P Bewley,2 Farhan Mughal,3 Karissa M Johnston,4 Andreas Kuznik,5 Chloe Patel,1 Andrew J Lloyd1

1Clinical Outcomes Assessment, ICON Clinical Research UK Ltd, 2Department of Dermatology, Whipps Cross University Hospital, Barts Health National Health Service Trust, London, 3Health Economics Outcomes Research, Celgene Ltd, Uxbridge, UK; 4Epidemiology, ICON Commercialisation and Outcomes, Vancouver, BC, Canada; 5Global Health Economics and Outcomes Research, Celgene Corporation, Summit, NJ, USA

Objective: Treatment options for psoriasis offer trade-offs in terms of efficacy, convenience, and risk of adverse events. We evaluated patients preferences with respect to benefitrisk in the treatment of psoriasis. Methods: A discrete choice experiment was conducted in adults from the UK with moderate-to-severe psoriasis using an orthogonal design with 32 hypothetical choice sets. Participants were randomly assigned to one of two surveys with 16 choice sets. Patients preferences were investigated with respect to the following attributes: reduction in body surface area affected by psoriasis, treatment administration (frequency and mode of delivery), short-term diarrhea or nausea risk, and 10-year risk of developing melanoma or nonmelanoma skin cancer, tuberculosis, or serious infections. A mixed effects logistic regression model generated relative preferences between treatment profiles. Results: Participants (N=292) had a strong preference to avoid increased risk of melanoma or nonmelanoma skin cancer (odds ratio [OR]: 0.44 per 5% increased 10-year risk) and increased risks of tuberculosis and serious infections (both ORs: 0.73 per 5% increased 10-year risk) and preferred once-weekly to twice-daily tablets (OR: 0.76) and weekly (OR: 0.56) or fortnightly (OR: 0.65) injections. Participants preferred avoiding treatments that may cause diarrhea or nausea in the first 2 weeks (OR: 0.87 per 5% increase) and preferred treatments that effectively resolved plaque lesions (OR: 0.93 for each palm area still affected). Conclusion: All attributes were significant predictors of choice. Patients preference research complements clinical trial data by providing insight regarding the relative weight of efficacy, tolerability, and other factors for patients when making treatment choices.

Keywords: benefit, discrete choice experiment, patients preferences, psoriasis, risk, treatment

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Scientists Favor Gene Editing, But Only For ‘Fixing Diseases’ – ValueWalk

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ValueWalk
Scientists Favor Gene Editing, But Only For 'Fixing Diseases'
ValueWalk
An international body of scientific experts has stated, with caution, that gene editing technologies should be allowed for treating diseases or disabilities. The US National Academy of Sciences and the National Academy of Medicine said in a 200-page ...
Gene Editing Could Make You SmarterFuturism

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Scientists Favor Gene Editing, But Only For 'Fixing Diseases' - ValueWalk

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Many genetic changes can occur early in human development – Science Daily

Posted: at 7:44 pm


Science Daily
Many genetic changes can occur early in human development
Science Daily
"The diagnostics lab Baylor Genetics is one of the pioneers in this new era of clinical genomics-supported medical practice and disease gene discovery research," Lupski said. "They are developing the clinical genomics necessary to foster and support ...

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Genetic variant linked to overactive inflammatory response – Medical Xpress

Posted: at 7:44 pm

February 28, 2017 Credit: Cardiff University

Researchers at Cardiff University have discovered that genetic variation is the reason why some immune systems overreact to viruses.

Previous research had already revealed that a gene called Ifitm3 influences how sensitive people are to the influenza virus, with a variant form of the gene making cells more susceptible to viral infection. The new research reveals that Ifitm3 also plays an important role in controlling the extent of the inflammatory response triggered by virus infection.

The study suggests that individuals with deficiencies in Ifitm3 may have an overactive immune response to viral infection and may therefore be helped by a combination of anti-inflammatory drugs in addition to medicine that directly targets the virus.

World-wide the frequency of the variant Ifitm3 gene is 1 in 400, although it is much more common in certain ethnicities.

Dr Ian Humphreys from Cardiff University's School of Medicine said: "Now we know that genetic make-up influences how the immune system copes with infections, not only by influencing how the body controls an infection but also by controlling how strongly the body's immune system reacts, we can design therapeutic strategies for individuals who are seriously ill with infections, which are tailored to the individual based on their genetic profile."

The data were collected using immune cells from mice with and without the variant form of Ifitm3, to observe how the immune system responds to a virus called cytomegalovirus. The results could also be relevant for other viral infections such as influenza epidemics/pandemics.

Explore further: Genetics of flu susceptibility: Researchers find gene that can transform mild influenza to a life-threatening disease

More information: Maria A. Stacey et al. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis, Journal of Clinical Investigation (2017). DOI: 10.1172/JCI84889

Researchers at Cardiff University have discovered that genetic variation is the reason why some immune systems overreact to viruses.

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new regulator of the innate immune responsethe immediate, natural immune response to foreign invaders. The study, published recently ...

A new discovery by researchers at the Fred Hutchinson Cancer Research Center in Seattle makes an important step in identifying which specific T cells within the diverse army of a person's immune system are best suited to ...

As much as we try to avoid it, we are constantly sharing germs with those around us. But even when two people have the same infection, the resulting illnesses can be dramatically differentmild for one person, severe or ...

Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseases as a possible treatment with fewer risks and lower costs than current therapies.

If you've ever wondered how a vaccine given decades ago can still protect against infection, you have your plasma cells to thank. Plasma cells are long-lived B cells that reside in the bone marrow and churn out antibodies ...

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Genetic variant linked to overactive inflammatory response - Medical Xpress

Posted in Gene Medicine | Comments Off on Genetic variant linked to overactive inflammatory response – Medical Xpress

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