Page 2,013«..1020..2,0122,0132,0142,015..2,0202,030..»

Category Archives: Transhuman News

Sangamo Therapeutics Receives Orphan Drug Designation from the FDA for SB-913 Genome Editing Treatment for … – PR Newswire (press release)

Posted: March 1, 2017 at 8:45 pm

In 2017, Sangamo is conducting a Phase 1/2 clinical trial evaluating SB-913 as an in vivo genome editing treatment for MPS II. Sangamo is also conducting Phase 1/2 studies this year evaluating in vivo genome editing treatments SB-318 for MPS I, another rare lysosomal storage disorder, and SB-FIX for hemophilia B, a rare blood disease. Data from these studies and from a clinical trial for a fourth lead program, SB-525, a gene therapy approach for hemophilia A, are expected in late 2017 or early 2018.

Sangamo's In Vivo Genome Editing Approach Sangamo's ZFN-mediated in vivo genome editing approach makes use of the endogenous albumin gene locus, a highly expressing and liver-specific site that can be edited with ZFNs to accept and express therapeutic genes. The approach is designed to enable the patient's liver to permanently produce circulating therapeutic levels of a corrective protein. The ability to permanently integrate the therapeutic gene in a highly specific, targeted fashion significantly differentiates Sangamo's in vivo genome editing approach from conventional AAV cDNA gene therapy. Ultimately, the target population for these programs will include pediatric patients, and it will be important in this population to be able to produce stable levels of therapeutic protein for the lifetime of the patient.

About Sangamo Therapeutics Sangamo Therapeutics, Inc. is focused on translating ground-breaking science into genomic therapies that transform patients' lives using the company's industry leading platform technologies in genome editing, gene therapy, gene regulation and cell therapy. The Company is advancing Phase 1/2 clinical programs in hemophilia A and hemophilia B, and lysosomal storage disorders MPS I and MPS II. Sangamo has a strategic collaboration with Bioverativ Inc. for hemoglobinopathies, including beta thalassemia and sickle cell disease, and with Shire International GmbH to develop therapeutics for Huntington's disease. In addition, it has established strategic partnerships with companies in non-therapeutic applications of its technology, including Sigma-Aldrich Corporation and Dow AgroSciences. For more information about Sangamo, visit the Company's website at http://www.sangamo.com.

Forward Looking Statements This press release may contain forward-looking statements based on Sangamo's current expectations. These forward-looking statements include, without limitation references relating to research and development of therapeutic applications of Sangamo's gene therapy and ZFP technology platforms, the potential of Sangamo's technology to treat hemophilia and lysosomal storage disorders, the expected timing of these clinical trials and the release of data from these trials, the impact of Sangamo's clinical trials on the field of genetic medicine and the benefit of orphan drug status. Actual results may differ materially from these forward-looking statements due to a number of factors, including uncertainties relating to substantial dependence on the clinical success of lead therapeutic programs, the initiation and completion of stages of our clinical trials, whether the clinical trials will validate and support the tolerability and efficacy of ZFNs, technological challenges, Sangamo's ability to develop commercially viable products and technological developments by our competitors. For a more detailed discussion of these and other risks, please see Sangamo's SEC filings, including the risk factors described in its Annual Report on Form 10-K and its most recent Quarterly Report on Form 10-Q. Sangamo Therapeutics, Inc. assumes no obligation to update the forward-looking information contained in this press release.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/sangamo-therapeutics-receives-orphan-drug-designation-from-the-fda-for-sb-913-genome-editing-treatment-for-mps-ii-300415719.html

SOURCE Sangamo Therapeutics, Inc.

http://www.sangamo.com

Go here to read the rest:
Sangamo Therapeutics Receives Orphan Drug Designation from the FDA for SB-913 Genome Editing Treatment for ... - PR Newswire (press release)

Posted in Gene Medicine | Comments Off on Sangamo Therapeutics Receives Orphan Drug Designation from the FDA for SB-913 Genome Editing Treatment for … – PR Newswire (press release)

Gene therapy lets a French teen dodge sickle cell disease – Medical Xpress

Posted: at 8:45 pm

March 1, 2017 by Marilynn Marchione This 2009 colorized microscope image made available by the Sickle Cell Foundation of Georgia via the Centers for Disease Control and Prevention shows a sickle cell, left, and normal red blood cells of a patient with sickle cell anemia. Researchers say a French teen who was given gene therapy for sickle cell disease more than two years ago now has enough properly working red blood cells to dodge the effects of the disorder. The case is detailed in the March 2, 2017 issue of the New England Journal of Medicine. (Janice Haney Carr/CDC/Sickle Cell Foundation of Georgia via AP)

A French teen who was given gene therapy for sickle cell disease more than two years ago now has enough properly working red blood cells to dodge the effects of the disorder, researchers report.

The first-in-the-world case is detailed in Thursday's New England Journal of Medicine.

About 90,000 people in the U.S., mostly blacks, have sickle cell, the first disease for which a molecular cause was found. Worldwide, about 275,000 babies are born with it each year.

"Vexing questions of race and stigma have shadowed the history of its medical treatment," including a time when blacks who carry the bad gene were urged not to have children, spurring accusations of genocide, Keith Wailoo of Princeton University wrote in a separate article in the journal.

The disease is caused by a single typo in the DNA alphabet of the gene for hemoglobin, the stuff in red blood cells that carries oxygen. When it's defective, the cells sickle into a crescent shape, clogging tiny blood vessels and causing bouts of extreme pain and sometimes more serious problems such as strokes and organ damage. It keeps many people from playing sports and enjoying other activities of normal life.

A stem cell transplant from a blood-matched sibling is a potential cure, but in the U.S., fewer than one in five people have a donor like that. Pain crises are treated with blood transfusions and drugs, but they're a temporary fix. Gene therapy offers hope of a lasting one.

The boy, now 15, was treated at Necker Children's Hospital in Paris in October 2014. Researchers gave him a gene, taken up by his blood stem cells, to help prevent the sickling. Now, about half of his red blood cells have normal hemoglobin; he has not needed a transfusion since three months after his treatment and is off all medicines.

"It's not a cure but it doesn't matter," because the disease is effectively dodged, said Philippe Leboulch, who helped invent the therapy and helped found Bluebird Bio in Cambridge, Massachusetts, the company that treated the boy. The work was supported by a grant from the French government's research agency.

Bluebird has treated at least six others in the U.S. and France. Full results have not been reported, but the gene therapy has not taken hold as well in some of them as it did in the French teen. Researchers think they know why and are adjusting methods to try to do better.

Two other gene therapy studies for sickle cell are underway in the U.S.at the University of California, Los Angeles and Cincinnati Children's Hospitaland another is about to start at Harvard and Boston Children's Hospital using a little different approach.

"This work gives considerable promise" for a solution to a very common problem, said Dr. Stuart Orkin, a Boston Children's Hospital doctor who is an inventor on a patent related to gene editing.

"The results are quite good in this patient," he said of the French teen. "It shows gene therapy is on the right track."

Explore further: BCL11A-based gene therapy for sickle cell disease passes key preclinical test

More information: Gene therapy: ghr.nlm.nih.gov/primer/therapy/availability

2017 The Associated Press. All rights reserved.

A precision-engineered gene therapy virus, inserted into blood stem cells that are then transplanted, markedly reduced sickle-induced red-cell damage in mice with sickle cell disease, researchers from Dana-Farber/Boston Children's ...

Sickle cell disease and the blood disorder beta thalassemia affect more than 180,000 Americans and millions more worldwide. Both diseases can be made milder or even cured by increasing fetal hemoglobin (HbF) levels, but current ...

Scientists at the Center for Regenerative Medicine (CReM) at Boston Medical Center (BMC) and Boston University School of Medicine (BUSM) are creating an induced pluripotent stem cell (iPSC)-based research library that opens ...

UCLA stem cell researchers have shown that a novel stem cell gene therapy method could lead to a one-time, lasting treatment for sickle cell diseasethe nation's most common inherited blood disorder.

A team of researchers at the Stanford University School of Medicine has used a gene-editing tool known as CRISPR to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward ...

Scientists have developed a new approach to repair a defective gene in blood-forming stem cells from patients with a rare genetic immunodeficiency disorder called X-linked chronic granulomatous disease (X-CGD). After transplant ...

A French teen who was given gene therapy for sickle cell disease more than two years ago now has enough properly working red blood cells to dodge the effects of the disorder, researchers report.

A research team, led by the University of Minnesota, has discovered a groundbreaking process to successfully rewarm large-scale animal heart valves and blood vessels preserved at very low temperatures. The discovery is a ...

Working with yeast and human cells, researchers at Johns Hopkins say they have discovered an unexpected route for cells to eliminate protein clumps that may sometimes be the molecular equivalent of throwing too much or the ...

By changing one small portion of a stimulus that influences part of one molecule's function, engineers and researchers at Washington University in St. Louis have opened the door for more insight into how the molecule is associated ...

A minimally invasive, fiber-optic technique that accurately measures the passive stretch and twitch contraction of living muscle tissue could someday be an alternative to the painful muscle biopsies used to diagnose and treat ...

An in-depth computational analysis of genetic variants implicated in both schizophrenia and rheumatoid arthritis by researchers at the University of Pittsburgh points to eight genes that may explain why susceptibility to ...

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Originally posted here:
Gene therapy lets a French teen dodge sickle cell disease - Medical Xpress

Posted in Gene Medicine | Comments Off on Gene therapy lets a French teen dodge sickle cell disease – Medical Xpress

What is Pompe disease? 5 things to know about the rare gene mutation – Today.com

Posted: at 8:45 pm

share

pin

email

During his address to Congress last night, President Donald Trump introduced Megan Crowley, a 20-year-old woman with a rare disease.

Crowley, who has a neuromuscular disorder known as Pompe disease, credits her survival to her father's small biotechnology company for developing and producing a therapy for the rare genetic mutation.

During the speech, the President suggested that Crowleys story highlighted the need to scale back regulations and to streamline the processes of the Food and Drug Administration. While Crowley's doctor welcomed the spotlight shown on Pompe disease and on rare diseases, in general, others cautioned that rushing experimental treatments through the Food and Drug Administration could have disastrous results.

Related: Speed up drug approvals? The FDA already did

The big problem isnt with the FDAs procedures, but rather a shortage of funds and the small numbers of people in whom scientists can study the ailments, researcher Dr. Puneet Opal told TODAY.

FDA drug approval procedures are intended to prevent patient deaths from experimental treatments, said Opal, a professor of neurology at Northwestern Universitys Feinberg School of Medicine.

"You do need the FDA to be the police dog," said Opal.

Crowleys physician, Dr. Priya Sunil Kishnani, division chief of medical genetics at the Duke University Medical Center, was excited to have rare diseases given such high-profile attention.

We diagnosed Megan at Duke in 1998 when she was just 15 months old. Its been an amazing journey to see how she has not just survived but is thriving despite her limitations, Kishnani, who is also professor of pediatrics and division chief of medical genetics, told TODAY.

Pompe disease occurs in an estimated 1 in 12,000 to 20,000 babies and people with an adult-onset form, according to Duke University experts. Crowley's fathers struggle to find a cure for the disease was profiled in the book The Cure: How a Father Raised $100 Million and Bucked the Medical Establishment in a Quest to Save His Children and also inspired a 2010 movie called Extraordinary Measures.

Megan Crowley listens as President Donald Trump addresses Congress.

Related: Parents race to save girl with rare, deadly disease

For those not familiar with Pompe, here are five things to know:

That means that a child must inherit two copies one from each parent to be affected by it. Children born with just one copy of the mutated gene are healthy and generally are completely unaware they have it.

When someone has both copies of the mutated gene, the body lacks enough of an enzyme that breaks down the starch glycogen into glucose, a form of sugar that fuels the muscles. The result is a damaging overabundance of glycogen.

Because the heart is also a muscle, damage to it is what generally kills patients even before there is respiratory distress, Opal said.

In babies, the earliest symptoms are not meeting motor milestones, Kishnani said. Babies might not hold their heads up or start rolling over at the expected age. They may not have the same strength as other babies of similar age.

"When you pick them up you feel like theyre almost slipping through your fingers," said Kishnani.

Respiratory symptoms or pneumonia might reveal a massively enlarged heart.

The severity of the symptoms and when they appear depend on the exact type of mutation. There are children who show up with worse symptoms than Crowley and others who show up with milder ones, Kishnani said.

The treatment isnt a cure for the disease, but it is lifesaving. Crowley is confined to a wheelchair and must use a ventilator to breathe.

These individuals do have a life," said Kishnani, talking about Megan's spunk and passion.

"She has life goals. People should not just look past her ... and think there are not going to be any cognitive abilities.

Read more here:
What is Pompe disease? 5 things to know about the rare gene mutation - Today.com

Posted in Gene Medicine | Comments Off on What is Pompe disease? 5 things to know about the rare gene mutation – Today.com

A New Cancer Treatment Has Given Terminal Patients a Second Chance at Life – Futurism

Posted: at 8:45 pm

Could This Treatment Cure Cancer?

Despite the many advances in medicine over the last century, a cure for one of the most prevalent and devastating diseases in the world todaycontinues to evade us. But thanks to new research, that could soon change.

Kite Pharma, a US pharmaceutical company, just released the groundbreaking results of their six-month gene therapy trial: terminal cancer patients incomplete remission after just a single round.

The treatment filters a patients blood to remove T-cells, immune system cells that can be genetically engineered in a lab to identify cancer cells. Cancer cells thrive because of their ability to evade the immune system.This new therapy boosts immune cells so that they are able to eliminate cancer cells more effectively.

Patients who participated in the trial had one of three types of non-Hodgkin lymphoma. The advanced stageof their conditions meant all of them were given only a few months to live. However, following the first round of gene therapy, which took place nine months after the trial began, half the patients are not only still alive, but a third of themappear to be cured.

Among them is a 43- year-old named Dimas Padilla from Orlando, Florida whose cancer had stopped responding to chemotherapy. He completed the first round of the trials treatment last August, and his cancer is now in remission.

These results are promising and suggest that one day CAR-T cells could become a treatment option for some patients with certain types of lymphoma, said head cancer information nurse, Martin Ledwick from the Cancer Research UK, in an interview with The Telegraph.

While the results are promising and could prove to be life- changing for patients with terminal cancer, the treatment is not without risks.

Because the therapy essentially puts the human immune system to go into overdrive by radically altering human cells, complications are certainly possible some of which could be fatal. In fact, during the trial, two people diedas a resultof the therapy not because of the cancer. Some patientsimmune systems overreacted in its effort to kill the cancer cells, while others developed blood-count related issues such as anemia. Reports of patients suffering from neurological problems were also cited, but these side effectsapparently only lasted a few days.

More studies are needed tounderstand the therapys side effects, potential complications, and long-term benefits.

The trials full results wont be presented until April, and the pharmaceutical company still has to get approval from the European regulatory boards which means it will be a while yet before the therapy becomes available. Given the possible risks, it might give them enough time to study the therapy further and refine the process hopefully eliminating any adverse effects.

Although, as the Cancer Institutes Dr. Steven Rosenberg points out: Its a safe treatment, certainly a lot safer than having progressive lymphoma.

Excerpt from:
A New Cancer Treatment Has Given Terminal Patients a Second Chance at Life - Futurism

Posted in Gene Medicine | Comments Off on A New Cancer Treatment Has Given Terminal Patients a Second Chance at Life – Futurism

Censorship in Saudi Arabia – Wikipedia

Posted: at 8:44 pm

Books, newspapers, magazines, broadcast media and Internet access are censored in Saudi Arabia.

In 2014, Reporters Without Borders describes the government as "relentless in its censorship of the Saudi media and the Internet",[1] and ranked Saudi Arabia 164th out of 180 countries for freedom of the press.[2]

The Royal Decree On Press and Publications (1982) set up the initial government regulation of Saudi books, newspapers and magazines, as well as all foreign publications sold in the kingdom. In addition to obtaining government permission, the Saudi citizen creating and distributing the content, had to ensure that it did not cause sectarian tension among citizens, or insult the royal family or Islamic values.

In 1992 the "Basic Law of Governance" was enacted as an informal Constitution. Article 39 of the kingdom's "Basic Law of Governance" states that

Mass media and all other vehicles of expression shall employ civil and polite language, contribute towards the education of the nation and strengthen unity. It is prohibited to commit acts leading to disorder and division, affecting the security of the state and its public relations, or undermining human dignity and rights. Details shall be specified in the Law.[3]

The Ministry of Interior has "responsibility for all the Saudi media and other channels of information".[4] The ministry has been called the "main agent of censorship" in the kingdom.[4] It is charged with the `purification` of culture prior to it being permitted circulation to the public. A special unit, the Management of Publications department, "analyzes all publications and issues directives to newspapers and magazines" stating that way in which a given topic must be treated.[4]

According to the Encyclopedia of Censorship

There is no precensorship of publications but if any material goes against a directive, or more generally qualifies as `impure`, the department will check it and notify the minister of information, who decides in what way and to what extent the publication and its employees are to be punished. The main effect of this system has been to impose on journalists rigorous self- censorship.[4]

Saudi Arabia directs all international Internet traffic through a proxy farm located in King Abdulaziz City for Science & Technology. A content filter is implemented there, based on software by Secure Computing.[5] Since October 2006, the Communications and Information Technology Commission (CITC) has been handling the DNS structure and filtering in Saudi Arabia in the place of KACST. Additionally, a number of sites are blocked according to two lists maintained by the Internet Services Unit (ISU):[6] one containing "immoral" (mostly pornographic or supportive of LGBT-rights) sites and sites promoting Shia Ideology, the others based on directions from a security committee run by the Ministry of Interior (including sites critical of the Saudi government). An interesting feature of this system is that citizens are encouraged to actively report "immoral" sites (mostly adult and pornographic) for blocking, using a provided web form, available on the government's website.

The initial legal basis for content filtering is the resolution by Council of Ministers dated 12 February 2001.[7] According to a study carried out in 2004 by the Open Net Initiative "the most aggressive censorship focused on pornography, drug use, gambling, religious conversion of Muslims, and filtering circumvention tools."[5]

This resolution was subsequently modified and expanded into The Anti-Cyber Crime Law (2007). Article 6 of this royal decree makes it a crime to produce, possess, distribute, transmit or store Internet content or a computer program that involves gambling, human trafficking, pornography or anything deemed to be against Islam, public morals or public order.

On 11 July 2006 the Saudi government blocked access to Wikipedia and Google Translate, which was being used to bypass the filters on the blocked sites by translating them.[8][9]

In 2011, the Saudi government introduced new Internet rules and regulations that require all online newspapers and bloggers to obtain a special license from the Ministry of Culture and Information.[10] The Communications and Information Technology Commission (CITC) is responsible for regulating the Internet and for hosting a firewall which blocks access to thousands of websites, mainly due to sexual and political content. Many articles from the English and Arabic Wikipedia projects are censored in Saudi Arabia with no given explanation.

As of 2014, Saudi Arabia has plans to regulate local companies producing input for YouTube. The General Authority for Audiovisual Media, a recently formed watchdog, will issue a public declaration to regulate the work of YouTube channels. They plan to censor material that is "terrorist" in nature which according to the proposed rule will be any content that "disturbs public order, shakes the security of society, or subjects its national unity to danger, or obstructs the primary system of rule or harms the reputation of the state".[11][12][13]

Any speech or public demonstration that is deemed to be immoral or critical of the government, especially the royal family, can lead to imprisonment or corporal punishment.

Saudi and foreign newspapers and magazines, including advertising, are strictly controlled by censorship officials to remove content that is offensive. Newspapers and magazines must not offend or criticize the Wahabi Muslims and especially The Royal family, Wahabi government officials or government version of Islamic morality.

Censorship of foreign newspapers and magazines tends to focus on content of sexual nature.[14] Nudity and pornography are illegal in the kingdom and this can extend to inking out public displays or affection like hugging and kissing, the uncovered arms and legs of women and men or anything deemed to be promoting "sexual immorality", such as adultery, fornication, sodomy or homosexuality. Even advertising for driving classes for women is banned, in keep with the ban in the kingdom.

In 1994, all Saudi women magazines were banned by the Ministry of Information. This move was considered to be related to the pressures of the religious establishment or ulema. After this ban, nineteen of twenty-four magazines closed down since their major revenue was advertisement earnings paid by the Saudi companies.[15]

Public cinemas have been illegal since the 1980s when conservative clerics deemed cinemas to be a waste of time and a corrupting influence.

In 2007, permission was granted to two hotels to screen American children's films, to celebrate the end of Ramadan. That following year the first Saudi film festival took place.[16]

Television and radio news, educational and entertainment programming is subjected to government censorship and control. Live television broadcasting on government-owned national TV stations was briefly suspended in 2008 after disgruntled callers on a live show on Al-Ikhbariya news channel displayed discontent with the latest governmental salary increases and made critical remarks of some Saudi officials. The minister of Culture and Information then fired the network's director, Muhammad Al-Tunsy, and replaced him with one of his personal assistants. The minister also formed a censorship committee of which the approval would be required prior to airing any program or inviting any guests on national television stations. The legal status of satellite receivers is in something of a grey area.[17]

In 1994, the government banned ownership of satellite television receivers but throughout the 1990s, an increasingly large percentage of the population bought a satellite receiver and subscribed to various programming packages. Despite the ban, the Saudi government was, generally, willing to tolerate satellite television as long as the programming content was not pornographic, critical of the Saudi government or Islam.[17]

In the 2000s, the Saudi government launched its own satellite stations and expressed a desire to work with other governments in the region to develop common censorship guidelines and restrictions.[18]

In 2005, the two-part episode of American Dad! named "Stan of Arabia" was banned by the Saudi government. The English daily ArabNews published an article that accused the series of "a particularly brutal portrayal of Saudis and Saudi Arabia"; although some of what was being shown, such as intolerance of homosexuality as well as the ban of alcohol, was true. As a result, the two-part episode was banned in Saudi Arabia, although the rest of the TV series itself can still be seen.[19]

See the original post here:
Censorship in Saudi Arabia - Wikipedia

Posted in Censorship | Comments Off on Censorship in Saudi Arabia – Wikipedia

Chinese Censorship of Feminism – Daily Trojan Online

Posted: at 8:44 pm

Photo from Womens March on Washington

Following the Womens March on Washington and its sister marches around the world, Chinese women were noticeably absent from the international media spotlights. This is because street protests and demonstrations that promote falsehoods are illegal in China, and the Chinese government has a history of cracking down and retaliating against public events and figures that bring light to gender inequality.

While the Chinese governments restriction of public protests and demonstrations is nothing new, over the past few years, China has been slowly increasing its censorship of feminist media and publications. For example, in 2015, the imprisonment by the government of the Feminist Five, a group of vocal Chinese womens rights activists, made headlines and led to an international outcry, leading to their subsequent release. The members of the group had been detained for distributing pamphlets about sexual harassment on March 8, International Womens Day.

This event from last year also mirrors a recent attack on feminist press. Just last week, a Chinese feminist social media account run on Weibo, a Twitter-like platform, was suspended for a month after it re-posted news about a strike taking place in the United States to honor International Womens Day. The account, Feminist Voices, which is one of the most popular in the nation with 80,000 followers, has temporarily moved to a different name. Citizens reacted with anger and fear on social media, warning of the threat to general civil liberties and to womens groups who want to remain outspoken against U.S. President Donald Trump and on gender equality issues.

However, besides high-profile cases such as this, the more insidious censorship and oppression of female artists and writers in China who dedicate their lives to the production of pieces that will inform and illuminate a worldwide audience has remained less publicized throughout the last year.

Consider the film Hooligan Sparrow, which was on this years short list for the Oscars category of feature length documentary. The director, Nanfu Wang, captured the story of Ye Haiyan, one of the most prominent womens rights activists in China. Ye and seven other activists risked arrest for publicly protesting against the outcome of a child rape case in Hainan involving a government official. Wang filmed undercover and smuggled the footage out of the country. The documentary was also nominated for the Grand Jury Prize at the 2016 Sundance Film Festival.

Before the announcements of the final Oscar nominees, local authorities shut off all of Yes utilities and Internet from her apartment on the outskirts of Beijing. The film was not ultimately included in the nominee list; if it had been, Ye would have had an extremely difficult time remaining in China and most likely would have had to leave the country somehow, though the government confiscated her passport in 2014. Ye is now facing eviction, and her daughter is not allowed to enroll in school because of Yes political activities.

The film is strictly prohibited from being shown within China but has garnered international acclaim. Wang and Chinese organizations have worked to plan underground screenings of the film domestically, risking government backlash.

Though the Chinese government supposedly supports the promotion of gender equality, it views any press or publicity that reveals a less-than-stellar status quo of womens rights as a threat to its order and stability. Working in these unfavorable conditions, Chinese feminists have increased efforts and are looking to forge alliances with other womens rights activists in the United States and beyond in order to foster international awareness. Journalists and activists such as Lu Pin, who is New York-based, have founded organizations such as the Chinese Feminism Collective that promotes the communication of Chinese feminism to Western nations.

Read the rest here:
Chinese Censorship of Feminism - Daily Trojan Online

Posted in Censorship | Comments Off on Chinese Censorship of Feminism – Daily Trojan Online

As North Koreans use phones, state finds new ways to censor – ABC News

Posted: at 8:44 pm

North Koreans have gained unprecedented connectedness with greater access to media and devices like cellphones over Kim Jong Un's five-year rule. But private citizens' embrace of a state-controlled network has opened the way to unparalleled state censorship and surveillance in the long-isolated, totalitarian country.

A U.S.-government-funded report, released Wednesday, said technology is giving North Korean authorities "more modern forms of control" as they step up efforts to stop foreign content creeping in.

"North Korea not only demonstrates technological sophistication but also has the ability to dictate what devices their citizens use, and they have complete control over hardware and software that essentially no other country does," said Nat Kretchun, co-author of the report by the consulting group Intermedia.

While the global explosion of network communications and internet use over the past two decades has provided surveillance opportunities for both authoritarian and democratic governments, North Korea's case is unique. The communist government prohibits public access to the World Wide Web. Outside media trickles in, but with significant challenges.

The state's stranglehold over the flow of information was first subverted during a famine in the 1990s when informal markets emerged and citizens began trading with each other. For the past decade or more, outside digital devices and content have flowed into North Korea across the border from China, enabling people to watch forbidden content, typically South Korean and Chinese soap operas.

The Intermedia report, which is based on interviews with North Korean defectors, refugees and travelers, found more such information making its way in over the past five years, notwithstanding Kim's intensified efforts to stop it. He took power after his father's death in late 2011 and has cracked down on smuggling and illicit viewing of foreign media.

Nearly every segment of society, from the elite in Pyongyang to farmers in inland areas, has access at least to televisions and DVD players, the report found. North Koreans have shifted toward using thumb drives instead of compact discs as they can hold more content and are easier to hide and share.

Viewing outside content, rather than the stodgy fare of state broadcasters, is shaping people's behavior.

The report quoted a 22-year-old construction worker who defected in 2014 as saying that South Korean and Chinese dramas have made men more willing to voice their affection to women. He said men increasingly marry women they date rather than having arranged marriages.

The report also cites respondents who have more than one TV. One is fixed to the state TV channel and put on display in the house; the other is concealed and dedicated to South Korean programing.

The government is finding new methods of control. Kretchun said North Korea was taking steps on regulation of cellphones "to regain control of the information climate." It can do so without relying on internet service providers to spy on people in its network, as other governments might.

There are now more than 3 million cellphone users in the North Korea-only network that was established in 2008. The growth has allowed authorities that traditionally relied on human surveillance to gain "a far greater ability to monitor the communications of its citizens," the report found.

Authorities have tried to stop people sharing and viewing nonsanctioned media content on their phones, the report said. Around three years ago, authorities updated software used by all phones, making nonsanctioned media files unplayable.

North Korea also uses a program that records the browsing history on the user's SD data card, making it harder to conceal illicit content. While laptops and computers are less widespread, the operating system they use "watermarks" files, allowing authorities to track their origin.

In effect, North Korean devices are "completely compromised," Kretchun said, creating options for state surveillance and censorship "much more effective than just about anywhere else."

To call outside the country, North Koreans need illicit phones that can tap into Chinese networks along the nation's northern border. Limiting that option is now a priority for North Korea, the report found, and its technological capability to locate users has improved.

See the original post here:
As North Koreans use phones, state finds new ways to censor - ABC News

Posted in Censorship | Comments Off on As North Koreans use phones, state finds new ways to censor – ABC News

Iranian TV censors got creative with Charlize Theron’s Oscars dress … – A.V. Club (blog)

Posted: at 8:44 pm

Despite not being there in person, Iranian director Asghar Farhadi won big at Sunday nights Oscars, taking home Best Foreign Language Film for his movie The Salesman. Farhadis victory was broadcast on Iranian TV, but not without a few alterations; according to The Hollywood Reporter, at least one outlet decided that presenter Charlize Therons Oscars dress needed some touch-ups before it could be broadcast to the people.

But the digital wizards at the Iranian Labour News Agency didnt content themselves with a mere blurring of Therons body; instead, someone at the state-run agency attempted to take advantage of the relative immobility of Oscar presenters to add their own flair to her outfit, filling in long black sleeves and a high neckline with what looked like the black spray paint tool from MS Paint. The effect wasless than convincing, especially when Theronpresenting with Shirley MacLaineabruptly moved, forcing her dress to trail a few seconds behind her.

As displayed in a video by Facebooks My Stealthy Freedom, the censor team at ILNA later reverted to a simple censorship bar for Therons body. But they got a little creative again when Iranian-American engineer Anousheh Ansari took the stage to accept the award on Farhadis behalf. (The director boycotted the ceremony in protest of the policies of President Donald Trump.) Rather than editing out all of Ansaris pretty modest dress, they simply filled in one exposed bit of skin with blurring, resisting the urge to add some earrings or a new pattern of their own devising to her ensemble as they did.

For the record, heres what Theron and Ansari were both wearing Sunday night:

(Photo: Kevin Winter/Getty Images)

(Photo: Kevin Winter/Getty Images)

Submit your Newswire tips here.

Read the original post:
Iranian TV censors got creative with Charlize Theron's Oscars dress ... - A.V. Club (blog)

Posted in Censorship | Comments Off on Iranian TV censors got creative with Charlize Theron’s Oscars dress … – A.V. Club (blog)

Rothbard’s Revenge: The Developing Libertarian-Right Alliance To Crush Leftist Influence In Modern Society – The Liberty Conservative

Posted: at 8:43 pm

The past week has been a wild one in the libertarian movement that resulted in a great deal of soul-searching and reflecting. With left-libertarians triggered and showing their nasty, totalitarian colors under the pressure, many rational libertarians are realizing that this poison must be removed from the movement post haste before even more damage is done.

Anarcho-capitalist author and philosopher Christopher Chase Rachels has taken the lead in this valiant effort. In an apparent response to the growing acceptance of violence, harassment, and mob tactics by left-libertarians, Rachels is striking back. He drafted a manifesto for his new right-libertarian alliance that he published earlier today.

We as the libertarian right seek first and foremost to promote a society whose prevailing legal system(s) is/are firmly rooted in the private property ethic and the NAP, Rachels said in his manifesto. That this is the fundamental core of the peaceful, civilized, and prosperous society.

Those words sound like doctrinaire libertarianism, but Rachels manifesto definitely could appeal to those on the right as well. Rachels cleverly outlined language to satisfy right-wingers who are growingly interested in forming model communities to rid themselves of leftists completely, a noble goal if there ever was one.

People have the right to pool their property and form whatever type of community they wish based on whatever cultural values they have so long as insodoing they do not violate the private property of others, Rachels said.

This means that right-wing people could clique up with fellow right-wingers, even if they happen to be white, and form exclusionary communities. While this notion may make a left-libertarian run shrieking to the safety of a lynch mob, right-libertarians understand that this is true freedom. Rachels alliance might finally be the vehicle to promote a consistent, unapologetic strain of libertarianism that unabashedly promotes freedom, no matter what the outcome.

Jared Howe of Being Libertarian has provided a great deal of intellectual ammunition on Rachels behalf as he embarks upon his new mission.

When the left organizes, the right traditionally does nothing, though this is rapidly changing, Howe said. When the right organizes, the left spergs the fuck out and lapses into hysterical purity spiraling, gaslighting and Kafkatrapping.

This tells me that the left is TERRIFIED of the right. As Brexit, the election of Trump, and the rise of the Alt-Right have demonstrated, the left clearly isnt going to prevail through verbal abuse alone. Thats why theyve been escalating and provoking violent conflicts with Trump supporters. For them, it isnt about being right; its about survival through parasitism.

As the libertarian movement inevitably splits along partisan lines, opportunities will arise for libertarians to regroup, strike back, and make a lasting impact. Rachels and Howe clearly understand the need to combat the stasis in the libertarian movement. Their project has the real potential to focus libertarian resources toward achieving necessary ends.

The alliance does not have a website at the current time, but interested individuals are encouraged to email [emailprotected] for more details.

Originally posted here:
Rothbard's Revenge: The Developing Libertarian-Right Alliance To Crush Leftist Influence In Modern Society - The Liberty Conservative

Posted in Libertarianism | Comments Off on Rothbard’s Revenge: The Developing Libertarian-Right Alliance To Crush Leftist Influence In Modern Society – The Liberty Conservative

Panaseeda | IMMORTALITY EXTRACT

Posted: at 8:43 pm

You're not only about to see how this revolutionary new - patented liquid vitality extract - is scientifically-proven to combat all "major causes of death" below, but also how it may ADD YEARS TO YOUR LIFE - while shedding years OFF your physical appearance!

See how this amazing extract can revolutionize your health and enhance your "life-span expectancy" - while combatting the most-threatening culprits like:

*You'll see how this life-giving extract, derived from "juicing a common food" - combats each of these threats - in detail, and MORE - on this page as you read below...

Location: Ontario, Activation Lab Facility Re: "The most essential substance you can feed your body today..."

This vitality secret has been woven in legends carried through centuries.

The Japanese have been long known for their longevity... and reputation for living long-healthy lives.

They also have among the lowest incidences of cancer and coronary heart disease.

And although not "all Japanese" habits are created equal - for the purposes of ultimate vitality & longevity, there is some very interesting history among their elite...

There is a definitive legend of ancient fisherman among the coastlines of the Suruga Bay - that were extraordinarily strong and infused with vitality - due to undiscovered-extracts they were taking.

As Shoguns caught word of this... after they too began consuming it, they also began requiring all their Samurai warriors to ingest this secret extract as well.

And even though the extracts reputation exceeded all expectations... no one really knew WHY it actually worked, or what it really was inside, or what it was called.

There was no particularly known reasoning for it's many health & life-giving properties!

All they knew is - somebody had caught a "deep sea shark" known as the dogfish shark (or aizame) in the pacific ocean, extracted oil from its liver - and decided to drink it!

...But it wasn't until 1906, that an unsaturated-hydrocarbon in this shark liver oil, was actually discovered, and deemed responsible for all the folklore.

And in 1916, it was publically announced by its given name -- Squalene.

(*and even at this time, Squalene was still only known to come from the liver of deep sea sharks)

In fact, Squalene has been the defining reason and answer to the question -

Technically, there have been less that 5 tumors ever discovered in Sharks...

So while it is a possible anomaly, cancer is almost non-existent in sharks.

To put this into perspective... a human would be about 1,000 times more likely to get "struck by lightning", than a shark would be to get cancer!

It's virtually non-existent!

Why sharks?

Sharks livers are made up of a tremendous amount of Squalene... which seems to have cancer fighting and preventative properties. And "deep sea" sharks contain the MOST - which is thought to be what enables them to go DEEPER into the ocean, and for longer periods of time.

The reason being, is Squalene's very unique ability to supply oxygen to the cells.

This is what gives Squalene the ability to enhance your body with...

The premier benefit of Squalene is its ability to supply Oxygen to your cells.

Simply put, when oxygen is deficient, cells deteriorate!

It is when the cells receive the necessary supply of oxygen - that the ultimate benefits of Squalene are received. Healthy oxygen-rich cells help in ensuring an efficient working body and the better conversion of nutrients into energy.

In Dan Buettners book, about "people who've lived the LONGEST" - he talks about the places these cultures each live, which he calls...

"The Blue Zones".

The main-distinction of what most "zones", or areas of people living in longevity shared - is they were extremely-rich in clean Oxygen!

Which brings up an important question...

..."What if you don't live on a (clean) beach or in the desolate Mountains?"

Well that's just it!

Here's how it works:

Oxygen rich cells allow more efficient removal of metabolic waste from cells providing better bowel movement, urination and efficient disposal through the respiratory system.

All are signs of good health - which is commonly seen when people ingest Squalene.

Think of how a healthy baby consistently moves their bowel at least two, if not three times per day. Young children typically also sleep more soundly because of their healthier cells.

In Japan, and other advanced countries, it's also widely known that stressed people head for either the mountain or sea-side resorts...

Why? To get "away from it all" and find seclusion, sure. But the other reason - is the kind of fresh oxygen supply found in these areas! People innately know it will make them feel better, even though most of them don't know WHY!

But Oxygenation is only ONE essential element. There is far more to...

"Squalene exhibits a remarkable ability to help strengthen the human immune system and is perhaps the most amazing immune enhancer ever discovered."

~North American Research Excerpts

The main cause of disease is thought to be cellular impairment.

And a major known cause of cellular impairment is due to oxygen deficiency.

(...Which we covered just a few moments ago, in regards to "The Blue Zone Effect".)

But the rabbit-hole goes much deeper...

Obviously we know that Squalene can enhance your health and combat disease through its oxygenation capabilities... but Squalene has many more remarkable traits.

To understand why it's so important to put Squalene in your body, lets start with...

What exactly Squalene is...

Squalene is an unsaturated-hydrocarbon and lipid found it small quantities in shark liver, olive, palm, and wheat germ oil. However, the highest containing source of Squalene in the world - is found in a "plant oil", without previous capabilities of proper extraction.

(Which you'll learn about in just a minute...)

But here's the most important thing you need to know about Squalene itself...

Squalene is the greatest anti-oxidant and anti-inflammatory oil in the world!

AND - It is also the ultimate skin rejuvenator for everlasting beauty and body health! Which is only logical, considering it's naturally found in your body and makes up about 12% of your skin!

In fact, here are a just a few of Squalene's remarkable abilities...

Lack of oxygen is the main voiced reason for development of cancer cells. Squalene has distinct anticarcinogenic effects, specifically on Cancer. Squalene is a chemoprotective substance and reduces risk of cancer and has anti-tumor property.

In a study involving the development of lung cancer, from tar induced toxicity, Squalene prevented 58% of all tumor growth.

Squalene is also a (powerful angiogenesis inhibitor) - which means it can prevent blood vessels from feeding tumors - by cutting off it's blood & food supply, potentially starving its growth!

Squalene prevents lipid peroxidation in human skin surface. Lipid peroxidation refers to the oxidative degradation of lipids (fats). It is the process in which free radicals "steal" electrons from the lipids in cell membranes, resulting in cell damage. It is also an extremely effective moisturizer.

Those that have applied Squalene Oils to their face and skin, have consistently reported it as "the most powerful skin rejuvenator and moisturizer ever used" - commonly resulting in softer, more even-toned skin, with a more "youthful" visual appearance!

They say "you're only as healthy as your gut". Well, Squalene is a cytoprotectant - which combats thinning of intestinal lining and can prevents ulcers by increasing mucosal protection in the stomach.

Squalene helps treat conditions resulting form inadequate immune response. Because of its potent immune-boosting effects, it's known to help against colds, flu, chronic infections, asthma, psoriasis, arthritis, and even AIDS.

Squalene is also a very strong immunostimulant and source of vitamin D - the "immunity vitamin", and our bodies can transform Squalene into sterols, which can also be converted into more Vitamin D!

Cholesterol is absolutely vital to human cell membrane structure. You simply cannot have a properly functioning cell membrane without healthy cholesterol!

Up to 80% of dietary Squalene is absorbed through the intestinal tract, and is converted to cholesterol in the human body!

This occurs because Squalene is a precursor to cholesterol. Squalene is converted into cholesterol via lanosterol. Healthy cholesterol, or HDL - not associated with LDL, or "bad cholesterol", is absolutely vital to great health.

HDL also makes up the inner-outer layer of every cell, as well as hormones essential for biomechanism. It's also an insulator for the nerves and is responsible for producing bile acids needed to digest fats in the gut. Thus, a body WITHOUT adequate healthy cholesterol, can break down from impaired function.

Because Squalene increases HDL, or "good cholesterol", it stimulates excretion of "bad cholesterol" in bile acids - helping lower dangerous "high cholesterol" that can contribute to heart disease - by improving our overall total cholesterol ratio, thus helping reduce the risk of heart disease!

Because Squalene is a precursor to important sterols such as cholesterol, it can improve hormone balance, as cholesterol is the basic building block for all bodily hormones.

Squalene supports the endocrine/hormone system because it allows hormones to be made with proper materials. Especially for even healthy vegans & vegetarians, there are not a lot of good sources of plant sterols (the main sterol in the human body is cholesterol).

Affected "hormones" include hormones like - testosterone, estrogen, androgens, Vitamin D, progesterone, and sex hormones. Why is the main reason Squalene is said to also improve...

Chinese medicine has long correlated "sexual vitality" with LONGEVITY... or simply living a longer, healthier life. Squalene aids in the production of adrenal hormones as well as sex hormones for both males and females... such as testosterone, estrogen, androgens, Vitamin D, progesterone, and other sex hormones. Thus, taking Squalene regularly improves sexual vitality!

Basically, the scrotum in the case of men, and the womb and ovaries in the case of women, have a very high cellular activity. As a result, nutrients and oxygen are continuously required in sufficient quantities.

The oxygen-supplying action of Squalene augments the cellular activity in these organs, thus increasing sexual vitality. Allowing you to also gain MORE ENERGY and...

But the philosophy of seeking these life-extending benefits goes beyond the "benefits themselves"... but rather... the importance of Squalene's ability to elevate your body's natural threshold for impairment.

Squalene can help your body "put up with more abuse" from chemicals, toxicity, oxygen deficiency, stress, general cellular impairment, and MORE...

These are just a few reasons why you should be ingesting Squalene on a daily basis!

Plus, Squalene is potentially the best natural protectant against -

"This is the greatest public health hazard the world has ever witnessed - apart from the threat of nuclear war."

~Dr. Helen Caldicott, MD

Radiation is a major, MAJOR threat.

To us, and to everyone else in the world.

We are exposed via a multitude of ways, including... microwaves, xrays, cell-phones, airport body scans, CT scans, cell towers, power lines, power plants, EMF's... airplane flights, etc.

Escaping this "everyday" radiation is near impossible.

But a MUCH BIGGER addition to this threat has been Fukushima's Nuclear Plant Disaster.

The Fukushima Daiichi Plant has continuously leaked over 300,000 gallons of radioactive poison PER DAY into the pacific... and years later today - it's STILL LEAKING!

The new found exposure from Fukushima is simply compounding onto our already threatening - daily exposure.

Recently there have been new reports of high levels of Radioactive CESIUM 137 - from the leakage, discovered right in the United States - found in everything from: seaweeds, fish, dairy milk, meat agricultural top soil - (used to grow produce), even breast milk!

Meaning: We are ingesting this radiation in our food... and there's nothing we can do about it.

Well... ALMOST nothing.

Obviously we can choose our food sources wisely, etc... but this problem is beyond that.

It lurks in our shore, ground and rainwater...

It's airborne. And it's coming for every one of us.

The health effects of radioactive particles from "normal daily exposure" alone, can be devastating.

Causing a variety of happiness-stealing issues, from - tumors, leukemia, central nervous system impairment, heart disease, and cancer, among others. It can also plague your family with birth complications, from: birth defects, spontaneous abortion, premature birth, still birth, to SIDS (sudden-infant-death).

Now, all radiation is extremely damaging, and accumulates... contributes to all cancers.

But things have gotten MUCH WORSE...

On March 11, 2011 the Fukushima Nuclear Power Plant had a meltdown, exposing the world to deadly radioactive isotopes.

Read more here:
Panaseeda | IMMORTALITY EXTRACT

Posted in Immortality Medicine | Comments Off on Panaseeda | IMMORTALITY EXTRACT

Page 2,013«..1020..2,0122,0132,0142,015..2,0202,030..»