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Category Archives: Transhuman News

NASA sending new plant system to space station – The Hindu

Posted: March 4, 2017 at 2:49 pm


The Hindu
NASA sending new plant system to space station
The Hindu
NASA is sending a new, nearly self-sufficient plant growth system to the International Space Station (ISS) that will help prepare astronauts to grow their own food during deep-space exploration missions. The new plant system will this month join Veggie ...
Bigelow Aerospace offers plan for an expandable space station orbiting the moon by 2020Next Big Future
NASA to send new plant system to space stationThe Siasat Daily
NASA Space Station On-Orbit Status 1 March 2017 - Station Orbit BoostedSpace Ref (press release)
Space.com -ScrollToday
all 25 news articles »

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Elon Musk and SpaceX Announce Return to Moon – PJ Media

Posted: at 2:48 pm

Excitement has been building all afternoon about an announcement by Elon Musk and SpaceX, and the story is finally out: two private citizens have contracted with SpaceX to be the first humans to make a deep-space trip in 45 years. The mission will be the second crewed use of the SpaceX Dragon Crew vehicle, following two tests to the ISS under NASA's Commercial Crew Program -- an un-crewed test later this year, followed by taking a crew early in 2018.

SpaceX already has a contract with NASA for three cargo and one crewed mission a year.

Unlike the NASA missions, this lunar circumnavigation will use SpaceX's Falcon 9 Heavy booster, which SpaceX developed privately. It will be launched from Pad 39A, the same pad used by the Apollo and Space Shuttle missions.

This announcement seems to steal a march on NASA and the acting head of NASA, Robert Lightfoot. On February 15, Lightfoot announced a study to determine whether the first test of the Orion and Space Launch System could be used to send two people to the Moon:

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Battling Leptospira at the genome level – The Hindu

Posted: at 2:47 pm


The Hindu
Battling Leptospira at the genome level
The Hindu
At a glance: At the heart of these efforts is the focus on a 'One Health' approach, which integrates efforts to predict and control a disease at the human-animal-ecosystem interface. Getty Images/iStockphoto | Photo Credit: jarun011/Getty Images ...

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Sanofi, Regeneron say latest Dupixent eczema drug tests positive – Reuters

Posted: at 2:46 pm

PARIS Drugmakers Sanofi and Regeneron said on Saturday results from a one-year test of their Dupixent product aimed at adults with eczema or moderate-to-severe atopic dermatitis (AD) had been positive.

"In the CHRONOS study, Dupixent used with topical corticosteroids showed significantly greater clearance of skin lesions and overall disease severity compared to topical corticosteroids alone, which are commonly prescribed for moderate-to-severe atopic dermatitis," Andrew Blauvelt, the principal investigator of the study, said in a joint statement from the companies.

"This study provides positive long-term data for Dupixent, which is important given atopic dermatitis is a chronic inflammatory disease," he said.

A biologics license application (BLA) for Dupixent was accepted for Priority Review by the U.S. Food and Drug Administration (FDA) in September 2016.

(Reporting by Matthias Blamont; writing by John Irish; Editing by Clelia Oziel)

MAIQUETIA, Venezuela Venezuelan plumber Marcos Heredia scoured 20 pharmacies in one day but could not find crucial medicines to stop his epileptic 8-year-old from convulsions that caused irreparable brain damage late last year.

(Reuters Health) - - Obese people in the U.S. may not receive the same kind of care at the end of their lives as people who are thin or normal weight, suggests a new study.

Johnson & Johnson said on Friday that a state court jury in Missouri had returned a verdict in its favor in the latest trial to arise out of thousands of lawsuits alleging the company's talc-based products can increase the risk of ovarian cancer.

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Sanofi, Regeneron say latest Dupixent eczema drug tests positive - Reuters

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Sex, Gene Editing, And Electronic Dance Music: How To Teach Entrepreneurship In Biotechnology Part 1 – Forbes

Posted: at 2:44 pm


Forbes
Sex, Gene Editing, And Electronic Dance Music: How To Teach Entrepreneurship In Biotechnology Part 1
Forbes
Next: a recent piece by Derek Lowe on the failure of Merck's BACE inhibitor for Alzheimer's, and last week I told the students to read up on and be prepared to venture pitch Editas Medicine (EDIT). During sessions 5 and 6, none of the assignments was ...

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Sex, Gene Editing, And Electronic Dance Music: How To Teach Entrepreneurship In Biotechnology Part 1 - Forbes

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Precision medicine test for breast cancer helps guide chemotherapy decisions – Knowridge Science Report

Posted: at 2:44 pm

One of the earliest widespread applications of precision medicine in cancer care is helping patients and physicians decide whether chemotherapy is needed, a new study finds.

Researchers reviewed a test that assesses the risk of breast cancer recurrence and whether chemotherapy is likely to help lower that risk in women with early stage disease.

The test looks at 21 genes known to increase risk of cancer recurrence. The idea is to avoid chemotherapy in women at such low risk that they arent likely to benefit from it and to ensure chemotherapy is recommended for women with higher risk.

Researchers surveyed 1,527 women with early stage breast cancer, noting whether they received the 21-gene recurrence score assay test and whether they subsequently received chemotherapy.

Currently, cancer care guidelines recommend the test for women with specific tumor features whose cancer has not spread to surrounding lymph nodes.

The study, published in Cancer, showed that most doctors recommended the test in line with these guidelines, though 13 percent of women with cancer in their lymph nodes still received the test.

Current guidelines typically recommend that these women should always receive chemotherapy, and therefore do not need the test. An ongoing clinical trial is looking at the value of the test for this group.

Among patients who had the test, the results aligned with the decision for or against chemotherapy: 87 percent of patients with a high score had chemotherapy.

For patients with the most favorable prognosis and the lowest test scores, only 3 percent received chemotherapy, compared to 13 percent of women who did not have the gene assay test but had a favorable prognosis.

An area of opportunity

Most patients accurately recalled receiving the test the researchers used registry and laboratory data to confirm that.

Nearly two-thirds thought the test was helpful, saying that their results helped shift their opinion for or against chemotherapy. Patients reported high satisfaction with their treatment choice.

Based on the diverse sample of patients, the researchers found that race or ethnicity did not play a role in the use of the recurrence score assay or in chemotherapy recommendations.

Although most examples of precision medicine involve clinical trials, the recurrence gene assay shows how precision medicine can be used in everyday clinical care.

Overall, the study shows use of the test, treatment recommendations and satisfaction all align. But the researchers note one opportunity.

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News source:Michigan Health. The content is edited for length and style purposes. Figure legend: This Knowridge.com image is credited to Michigan Health.

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Why Indian Censorship Is Hurting the Country’s Cinema – IndieWire

Posted: at 2:43 pm

Its always something with the Indian censors.

This time, its the refusal of the Central Board of Film Certification (CBFC) to grant filmmaker Alankrta Shrivastavas Lipstick Under My Burkha certification for a theatrical release in India. The film, a drama following four women in small-town India exploring sexual empowerment, freedom from patriarchy, and personal fulfillment won the Oxfam Award for Best Film on Gender Equality at the Mumbai Film Festival last October and the Spirit of Asia Award at the 2016 Tokyo International Film Festival, with upcoming screenings at festivals everywhere from Miami to Glasgow. The boards rejection of the film reignites familiar outrage, as the filmmakers and audiences alike have taken to social media to slam the decision as an assault on womens rights.

Infuriating as it is, this is hardly the boards first frustrating clampdown. The CBFC has long been the bane of films that push the envelope as far as social issues or physical intimacy are concerned. Some may recall the outright bans in the past of movies deemed too vulgar, like Shekhar Kapurs Bandit Queen in 1994, or Mira Nairs Kama Sutra A Tale of Love in 1996. More recently, in 2015, it raised objections to sex scenes in films like Anupam Sharmas UnIndian and Shonali Boses Margarita With a Straw, calling for re-edits that shortened the allegedly offensive depictions before clearing them for release.

And in its most high-profile and heavily disputed controversy to date, the CBFCcalled for a record 94 cuts pertaining to strong language, drug use and the mention of state names in last Junes star-studded Udta Punjab, arguing that the content jeopardized the countrys integrity and could compromise tourism in the region.

With a group as notoriously orthodox as the CBFC so often standing between films and theaters, then, some may say that the content of Lipstick Under My Burkha bold in the context of Indian cinema was bound to raise a few flags. But the refusal to certify this film, while unsurprising, has hit a particularly raw nerve for the wording used to explain its decision. The boards letter to the films producer, Prakash Jha, stated that the story is lady-oriented, their fantasy above life. There are contanious [sic] sexual scenes, abusive words, audio pornography, and a bit [sic] sensitive touch about one particular section of society, hence film refused under guidelines.

Its already flawed logic to deem a film inappropriate merely because it provides a perspective that could be displeasing to a certain segment of the audience. But to specify that the content is unsuitable precisely because it prioritizes the physical and emotional expression of female characters takes the decision to new levels of hypocrisy. Despite the widespread outrage over social media by industry members and audiences alike, the CBFC has only doubled down on its rejection. Board member Mamta Kale defended the decision, claiming that being a woman, you can talk about your sexual rights but you have to keep one thing in mind as to how you are showing that issue. Can families go together to watch such a movie? No, they cannot.

The argument is weak, given that watching movies especially non-mainstream ones like Lipstick Under My Burkha is less of a family affair in India today than it once was. More importantly, its a tone-deaf assessment from a group that evidently believes that routinely objectifying women for the sake of the male gaze qualifies as family-friendly entertainment.

In fact, if placing fantasy above life werentacceptable, an overwhelming proportion of mainstream, escapist Bollywood should have been banned as unsuitable for Indian audiences by now. For decades, weve watched item numbers cater predominantly to male sexual imaginations, whether in their early iterations in 1930s, when actresses playing cabaret dancers would shimmy for a roomful of men to lyrics dripping with innuendo, topresent-day Bollywood, where lithe actresses do essentially the same thing, only in even skimpier costumes, much to the delight of men ogling and hooting from the lower stalls of cinema halls.

Theres been little pushback by anyone of influence to the notion of stalking as an appropriate form of wooing a woman, a strategy that began in the 60s, when heartthrob Shammi Kapoor made it look like innocent persistence rather than harassment, and has continued to this day with 2014s Raanjhanaa, 2016s Sultan, and possibly even in the upcoming Badrinath Ki Dulhania next month. Actors over the age of 50 still woo heroines less than half their age, and actresses half-naked bodies are still plastered on posters and highlighted in film trailers to shamelessly lure in the male contingent.

The CBFC has protested to little, if any, of this. Yet the moment an outspoken film like Lipstick Under My Burkha gives female perspectives a realistic voice, or attempts to shed light on how women discover and experience their own fantasies, the censor board decides that a lady-oriented film is inappropriate. The message is clear: A male fantasy is a natural expression of masculinity; its female equivalent is somehow a threat to the sanctity of Indian society.

Its a double standard so blatant, it delegitimizes any lingering credibility the CBFC enjoyed, and throws into question the sincerity of any government calls to support creative liberty over excessive moral policing. The eventual court ruling last June to release Udta Punjab with an A (restricted to adults) certificate and a single cut, seemed to be an encouraging move pushing the board to stick to its role of certification rather than censorship. For many, it was an indication that audiences could henceforth make their own judgements about what they should or shouldnt watch. The ability of a movie like last years Parched a daring and sometimes explicit critique of misogyny in rural India to escape relatively unscathed from the boards easily offended sensibilities further re-stoked the sputtering confidence of the public.

But those hopes were extinguished just as fast when the CBFC kicked off a year-long battle with the makers of Haraamkhor, the BAFTA-nominated film about arelationship between a teenage student and her teacher, after deeming the subject matter not suitable for India. (The film was finally released in January after several enforced cuts made it suitable for a U/A certificate.) Later last year, outrage was sparked once again after the trailer of Hansal Mehtas Aligarh was restricted to adult-only audiences simply due to its mention of the word homosexuality.

By outright refusing to give Lipstick Under My Burkha a certification at all, effectively blocking a theatrical release, the CDFC confirmed that for all the alleged intent to certify rather than cut, it essentially remains a censorship body. Exercising creative liberties in India remains an exhausting, one step forward, three steps back process, at the mercy of an overly conservative boards arbitrary guidelines of what constitutes appropriate entertainment or art.

As far as Lipstick Under My Burkha goes, director Shrivastava has vowed to fight for the films big-screen release in India though it remains to be seen whether it can happen with or without edits that inevitably dilute the films message. As the country misses out on the bold storytelling talent of its own natives, well appreciate that the rest of the world can still acknowledge what India has to offer and hope that Netflix is watching.

Watch the trailer of Lipstick Under My Burkha below:

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The End of the Libertarian Dream? – POLITICO Magazine

Posted: at 2:42 pm

Justin Amash cant seem to concentrate. His eyes keep drifting toward the TV behind me, mounted on the wall inside his congressional office. The 36-year-old representative from Michigan, who arrived in Washington six years ago as a self-described libertarian Republican, is rattling off a list of concerns about the newly inaugurated president, but he is distracted by C-SPANs programming: Mick Mulvaney, his close friend and colleague from South Carolinaand a similarly libertarian-minded Republicanis getting grilled during his confirmation hearing to become director of the Office of Management and Budget. Arizona Senator John McCain had just finished his inquisition and was particularly harsh, scolding Mulvaney for voting to slash military spending and withdraw American troops from Europe and Afghanistan. It was a tense exchange, and Amash savored every moment of it. The ascent of Mulvaney to such a powerful position in the federal government, libertarians believe, proves that their ideology has invaded and influenced the Republican mainstream in a manner unimaginable a decade ago.

There is, however, a complicating factor: Mulvaneys new boss is President Donald Trump.

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In campaigning for the presidency, Trump frequently sang from the same hymnal as libertarian primary rival Senator Rand Paul, warning against regime change and nation-building abroad, decrying the allied invasions of Iraq and Libya (never mind that Trump initially supported both), and promising to disengage from a self-immolating Middle East while re-evaluating American involvement in NATO. The election of an ideologically unmoored reality-TV star was startling to many libertarians, but at least it suggested some progress in their struggle with the GOPs interventionist wing. The silver lining is that Trump proved you can win the Republican nomination, and the presidency, by criticizing neoconservative foreign policy, says David Boaz, executive vice president of the libertarian Cato Institute.

I think the McCain-Graham wing of the party is withering, Amash tells me in his office, referring to South Carolinas hawkish senator. It was dominant 10 or 15 years ago on foreign policy matters and surveillance and other things. But today, its a rather weak force compared to a decade ago in D.C. And its almost nonexistent at home.

And yet, Trump also pledged to oversee a massive military buildup. He threatened to bomb the shit out of the Islamic State; suggested killing the families of terrorists; expressed an interest in seizing Iraqs sovereign oil; advocated the return of torture; and, in his inaugural address, declared he would eradicate Islamist terrorism from the face of the Earth. When I mention all this, Amash bursts out laughing. Not exactly a libertarian philosophy, I say. No, he shakes his head. Its not.

There are areas, certainly, in which Trumpism and libertarianism will peacefully co-exist; school choice, as evidenced by Trumps selection of Education Secretary Betsy DeVos, is one example. Deregulation is another. But by and large, they cannot be reconciled. Where libertarians champion the flow of people and capital across international borders, Trump aims to slow, or even stop, both. Where libertarians advocate drug legalization and criminal justice reform, Trump and his attorney general, Jeff Sessions, seek a return to law-and-order policies. Where libertarians push to protect the First and Fourth Amendments, Trump pushes back with threats of banning Muslims and expanding the surveillance state. And where Mulvaney has dedicated his career to the argument that dramatic fiscal measures are needed to prevent the United States from going bankrupt, Trump campaigned unambiguously on accumulating debt, increasing spending and not laying a finger on the entitlement programs that make up an ever-growing share of the federal budget.

THE LIBERTARIAN STANDARD-BEARERS: Rep. Justin Amash and Sen. Rand Paul outside the Capitol in 2015. | Bill Clark/CQ Roll Call

Sooner or later, something has to give. Mick knows the numbers. And hes going to get to, at some point, a soul-testing moment, Mark Sanford, his fellow South Carolina representative and a self-identified, lifelong libertarian, tells me. Do I go with, you know, what Donald is saying? Or do I go with what I know to be mathematic reality?

This disconnect captures the sense of uncertainty and conflict that libertarianswhether they are Republicans, Democrats or adherents of the eponymous third partyfeel in the age of Trump. After generations of being relegated to the periphery of American politics, they are seeing some of their most precious ideals accepted and advocated for at the highest levels of government. But in many policy areas, there has never been a president who poses a greater threat to what they hold dearone who is poised, potentially, to reorient the GOP electorate toward a strong, active, centralized and protectionist federal government. The Trump presidency, then, is shaping up to be a defining moment for the libertarian movement.

But it wont come down to intraparty disputes over marijuana, or sentencing reform, or government data collection. Rather, the viability of libertarianismfor the next four or eight years, and potentially much longerwill be determined to an overwhelming extent by the relative stability of international affairs and the level of security Americans feel as a result.

Not long ago, libertarians were having their long-awaited moment, with Rand Paulsupposedly the candidate who could rebrand their once-fringe ideology for a new generation of Americansgracing magazine covers and converting Republicans to a philosophy of laissez-faire at home and restraint abroad. But the reason he isnt president today, his allies say, owes equally to the rise of Trump and that of another disruptive phenomenon.

Two people were Senator Pauls undoing in the presidential race, Chip Englander, his campaign manager, tells me. Donald Trump and Jihadi John.

DEFINING MOMENT: At a 2007 primary debate, Ron Paul argued U.S. interventionism led to 9/11. | Mark Wilson/Getty Images

Libertarians call it the Giuliani moment. It was May 15, 2007, and the former New York mayor stood across from Ron Paul on a debate stage in Columbia, South Carolina. They had nothing in commonpersonalities and ideologies aside, Rudy Giuliani was comfortably leading the GOP presidential field, while Paul was polling in the low single digitsbut they would soon produce an inflection point in the partys modern history, one that triggered a decade of unprecedented progress for libertarians.

As a panel of Fox News moderators mocked his opposition to the Iraq War, Paul argued that American intervention in the Middle East was a major contributing factor to the September 11 attacks. Have you ever read the reasons they attacked us? he asked. They attack us because weve been over there. Giuliani, whose candidacy arose from his heroic handling of 9/11, pounced, calling it an extraordinary statement and asking Paul to withdraw it. The crowd roared with approval, but Paul didnt budge. I believe very sincerely that the CIA is correct when they teach and talk about blowback, he responded.

That statement, better suited to an Ivy League faculty lounge than a Republican debate stage, was the spark that started everything, says A.J. Spiker, the former Iowa GOP chairman who backed Ron Paul and later his son Rand for president. Before long, there was talk of a Ron Paul Revolution, which somehow wasnt an overstatement: As he climbed in the polls and gained name recognition, Paul began raising eye-popping sums of money online with the help of liberty movement groups that had begun forming across the country, with much of their grass-roots energy concentrated on college campuses.

There was, however, an unintended consequence: Pauls popularity served to cement libertarianisms reputation as an exotic strand of internecine opposition rather than a reliable, cooperative piece of the GOP coalition. Even though he emphasized other issues in his campaignmost memorably, auditing the Federal Reserveit was Pauls harsh critique of President George W. Bushs interventionism that defined his candidacy in 2008 and again in 2012, as well as his sons political ambitions, in the eyes of the party elite.

He alienated a lot of Republicans with a very isolationist foreign policy message, says Bob Barr, the former Georgia congressman who abandoned the GOP and became the Libertarian Partys presidential nominee in 2008. Barr, listening to Paul that year, recalls thinking, If libertarians continue to exist on ideological purity in that regard ... it will condemn them to not expanding their influence in the party.

The Republican establishment was banking on exactly that. Having watched with alarm as Pauls 2012 campaign attracted significantly more support than its 2008 iteration, the partys elder statesmen were eager to undermine the movements long-term viability. When I spoke with Karl Rove a month after Election Day 2012, he predicted libertarianism would soon regress to pre-Paul irrelevance. I dont think the antiwar sentiment is durable, Rove told me. The Republican Party is not going to find itself in five or 10 years committed to neo-isolationism.

In the year that followed, Roves prediction looked anything but prescient. In July 2013, Amash sponsored an amendment to restrict the National Security Agencys bulk data collection program; it fell just 12 votes shy of passage in the House, despite fierce opposition from President Barack Obama and the congressional leadership of both parties. That amendment was inspired by blockbuster revelations a month earlier, made by intelligence contractor Edward Snowden, that the governments domestic surveillance practices were illegal. That followed a watershed moment in March 2013, when Rand Paul, then a freshman senator from Kentucky and inheritor of his fathers messianic following, had completed a nearly 13-hour filibuster in opposition to the nomination of John Brennan as Obamas CIA directorand more broadly, to the administrations refusal to rule out drone strikes on American citizens. This momentum was validated by Republican leader Mitch McConnell, a mascot of the Washington establishment, hiring Jesse Benton, the Paul family consigliere, to manage his own 2014 Senate reelection.

With another White House campaign on the horizon, the dreams of a movement rested on the younger Pauls shoulders. Everyone recognized that the disheveled, curmudgeonly 70-something Ron could win hearts and minds but never the presidency. Randmore polished, more nuanced and nearly 30 years youngerwas the libertarians chosen one. (Gary Johnson, the Libertarian Partys 2016 nominee, was never taken as seriously.) Ron had won 21 percent of the vote in Iowa and 23 percent in New Hampshire in the 2012 primary; Rand, in the eyes of his bullish base, had nowhere to go but up.

Sure enough, by July 2014, he sat atop the GOP presidential field in the RealClearPolitics average of national surveys; that same month, NBC News released polls showing him leading in New Hampshire and tied for first place in Iowa. As he prepared to launch his campaign in early 2015, Paul basked in hisand the libertarian movementsascendance, which crescendoed with an August 2014 New York Times Magazine feature, with the headline, Has the Libertarian Moment Finally Arrived? It was met with hosannas inside Pauls political operation.

Twelve days after the Times piece was published, an organization known as the Islamic State, or ISISwhich had announced the formation of a caliphate to govern Muslims worldwide, but globally was not yet a household namereleased a video depicting the beheading of American journalist James Foley. Exactly two weeks later, ISIS published a similar video showing another American journalist, Steven Sotloff, also being beheaded. With the spectacular barbarism piercing Western consciousnessamid wall-to-wall coverage, the executioner was dubbed Jihadi John by media outletsObama delivered a prime-time address on September 10 and pledged to destroy ISIS.

The next month, Time magazine featured Paul on its cover as The Most Interesting Man in Politics. The timing could not have been worse: Having intended to capture Pauls rise, the story marked the onset of his decline. He had already dropped to 12 percent in the RCP national poll average, from 14 percent in July; by Christmas, he was at 9 percent. The crash continued throughout 2015, interrupted by only a fleeting bounce after his April 7 campaign launch. In late July, he was below 6 percent, and by October, one year after Times cover, he hovered at just over 2 percent.

We did a survey in Iowa that fall, and in the survey, Republican caucus-goers were very much opposed to the policies that Senator Paul was waving the flag for: less spying, less drone strikes, less foreign intervention, closing of foreign bases, recalls Vincent Harris, the campaigns chief digital strategist.

Embarrassingly, Pauls numbers plunged so low that Fox Business excluded him from its main debate in January 2016, less than a month before Iowas first-in-the-nation caucuses. (Paul boycotted the undercard debate.) A few weeks later, after winning just 4.5 percent of the vote in Iowa, Paul quit the race.

THE NEW BOSS: Rand Paul with Donald Trump after the president signed a bill undoing a coal rule. | Rex Features/AP

It was a dramatic, if unsurprising, fall from grace. Ron Paul had masterfully exploited the frustrations of a war-weary Republican Party, and though his son was hyped as an objectively superior messenger, everyone understood the foundation of his appeal could crumble with a sudden shift in public opinion. We as libertarians know that at a time of fear, our brand doesnt sell very well, says Jack Hunter, the editor of Rare Politics and co-author of Rand Pauls 2011 book, The Tea Party Goes to Washington. So when we saw beheadings on the news ... we knew it would be problematic.

Polling suggested as much. In November 2013when Rand Paul was riding high43 percent of Republicans said U.S. anti-terrorism policies were going too far in restricting civil liberties, while 41 percent said they werent going far enough to protect the homeland, according to Pew Research. In September 2014during the immediate aftermath of the Foley and Sotloff execution videosthose figures were 24 percent and 64 percent, respectively. The shift in sentiment would only accelerate. A separate poll in September 2014, commissioned by CBS News, found that 39 percent of Americans favored sending U.S. ground troops to Iraq and Syria to fight ISIS, with 55 percent opposed. Five months later, in February 2015, the percentages inverted: 57 percent of Americans wanted U.S. ground troops deployed to battle ISIS, and 37 percent were opposed. (Among Republican voters, it was 72 percent and 27 percent, respectively.)

To remain competitive, Paulwhose candidacy was already suffering from other manifest shortcomings, lack of financial support and personal prickliness chief among themtried to thread an impossible needle: projecting greater toughness to reassure mainstream Republicans, without sounding so muscular as to alienate his base. We accomplished neither, Tony Fabrizio, the Paul campaigns pollster, says. With all respect to Rand I think he wanted to prove he and his father were different. And that created natural tensions. By trying to please both sides, he wound up pleasing neither.

Drew Ivers, who chaired Ron Pauls 2008 and 2012 campaigns in Iowa, shocked his fellow libertarian activists by declining to endorse Rands 2016 bid. I remember him telling me once by phone that he was going to submit a proposal to go to war with ISIS, Ivers tells me. Go to war? Wait a minute. What do you mean, go to war?

I busted his chops about it, Matt Welch, editor at large of Reason, recalls of Pauls proposed declaration of war. And he said to me, Look, I cant win a Republican primary under these conditions if I dont support some kind of confrontation with ISIS.

Paul declined an interview request for this article. His spokesman, Sergio Gor, said in an email, Our focus is on Obamacare repeal and replacement exclusively right now. More accurately, the senators friends and allies say, he simply has no interest in re-litigating his presidential run or participating in a post-mortem of it.

Ironically, there was one Republican in 2016 who outdid Ron Pauls rants against Bushs interventionismand he won the partys nomination. Look at Trump. He went to South Carolina, a military state, and said the Iraq War was a disaster, said 9/11 happened on Bushs watch, shared these borderline conspiracy theories, Welch says. He was stridently antiwar and anti-interventionand he stomped the competition.

Trump had beaten Paul at what was supposed to be his own game.

***

Its the wild card of global affairsand the terrible hand it dealt Pauls 2016 campaignthat distracts from libertarianisms successful infiltration of the domestic policymaking complex. Education, which Republicans nationalized under Bush, is increasingly being handed back to the states. A coalition of liberal Democrats and conservative Republicans has begun challenging the status quo on issues ranging from police militarization to asset forfeiture to sentencing reform. Meanwhile, two of the libertarian communitys other longtime goals, marijuana decriminalization and marriage equality, have been realized in irreversible ways.

And yet, all of this momentum might be rendered insignificant, even irrelevant, if the new Republican president ends up going to war. In fighting for the heart and soul and future of the GOP, libertarians understand their chief strategic priority is holding Trump to his non-interventionist rhetoric. This explains why Paul was willing to support Sessions nomination, despite the new attorney generals sharply divergent views on issues such as drug prosecution and asset forfeiture: Paul, it appears, would rather spend what political capital he has opposing anyone who might inflame Trumps foreign policy. (Do not let Elliott Abrams anywhere near the State Department, the Kentucky senator wrote the week of Sessions confirmation vote, responding to reports that Trump could pick the well-known neoconservative to be deputy to Secretary of State Rex Tillerson.)

So far, Paul and his ilk are taking some comfort in the company Trump keeps. The president passed on hiring Abrams. And the principals of Trumps national security teamTillerson, Defense Secretary Jim Mattis, Homeland Security Secretary John Kellyare regarded as pragmatic realists who will restrain, rather than encourage, the presidents more aggressive instincts.

TRUMPs LIBERTARIAN: Mick Mulvaney is sworn in as director of the Office of Management and Budget. | Ron Sachs/picture-alliance/DPA/AP Images

That said, Trump, who loves to be called a man of action, feels a mandate to escalate various conflicts with Americas enemies. Exit polls on Election Day found that 24 percent of all voters thought the fight against ISIS was going very badly, and Trump won 83 percent of that group. Some in the Pentagon reportedly want to send ground forces into Syria. Trump has already proved unhesitant to deploy American troopsspecial operators at minimumto foreign soil. That he decided to greenlight a tremendously dangerous operation in Yemen almost immediately after taking office shows an appetite for boldness and a willingness to accept collateral damage; a Navy SEAL, as well as several civilians, were killed in the operation.

Its not what President Rand Paul would have done. And yet libertarians, who feared they ultimately would choose between an interventionist Democrat in Hillary Clinton and a neoconservative Republican nominee, still believe, perhaps naively, that this was their next best outcome. Marco Rubio, the hawkish Republican senator from Florida, would have been much worse for us, Amash tells me. I think Rubio would have ushered in a long decline of American foreign policy. Trump is just a shock to the system. Rubio is a younger, more charming John McCain.

In any case, the grass-roots foundation laid by Ron and Rand Paul seems likely to outlast Trump. Young Americans for Liberty, the group that grew out of Rons 2008 campaign, went from 96 chapters nationwide in 2009 to 602 chapters in May 2015, the month after Rands campaign launched. Today, there are 804 chapters. This growth, combined with continuous, non-election-year activismand polling showing that younger voters, both left- and right-leaning, are increasingly libertarian in their views of governmentwards off pessimistic assertions that their moment might have just come and gone.

Look at every single candidate who ran, and look at their infrastructures, Cliff Maloney, president of Young Americans for Liberty, tells me. Do you see people out still knocking doors for Marco Rubio or Jeb Bush or Ben Carson? No. This is going to be a slog. And were going to fight through.

The more important fight will take place on Capitol Hill. With the vast majority of Republicans already capitulating to Trump, libertarian-minded lawmakers are positioned as the most vocal bloc of intraparty opposition. Ron Paul was a lonely voice of dissent in Bushs GOP, and benefited politically when the party faithful eventually came around to some of his arguments. Today, theres a much larger contingent in the Congress oriented toward libertarianismAmash, Sanford, Thomas Massie of Kentucky and others in the House; Rand Paul and Mike Lee in the Senateand it has already shown a willingness to tangle with Trump where others in the party have passed. The aggressiveness with which libertarians check Trumps overreach, at home and abroad, will correlate with the movements credibility, and popularity, if Republican voters turn against the presidents policies.

But what if they dont? Knowing the Libertarian Party just nominated its most experienced presidential ticket ever and won just 3 percent nationally, the grave fear among libertarians is that Trumps actions will represent the very worst of his campaign promisesintervening militarily, adding to the debt, abandoning trade, restricting civil libertiesand that the GOP electorate will love him for it.

If the Republican Party becomes thoroughly Trumpist, Boaz says, theres not much room for libertarians.

Tim Alberta is national political reporter at Politico Magazine.

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Iowa makes Libertarianism official – Death and Taxes

Posted: at 2:42 pm

There are three duties two-time Iowa Secretary of State Paul Pate swore to uphold upon retaking office in 2014: compliment Senator Joni Ernst on her timeless hairdo, consume plenty of local cold brew coffee, and legitimize any third party that met established criteria. And earlier this week, Patewho we assume ran for secretary 20 years removed from his first tenure because Cedar Rapids Mayordidnt flow so seamlessly with his surnamegot to execute that latter privilege.

Upon releasing an inscrutable document detailing Iowas final voter-registration totals from the 2016 general election, Pate took to social media and declared that the Libertarian Party now had an official place on state voter-registration forms as of 2018s primaries.

Credit is due to Gary Johnson (not an oft-used phrase in 2017), who secured just under four percent of Iowans presidential votes. And sincea candidate need only exceed two percent of the in-state vote to have their party officially recognized, Johnson and his followers in the Hawkeye State can take a bow and bask in their authenticity.

According to local publication Daily Nonpareil, there are close to 10,000 registered Iowa Libertarians, a roughly five-fold increase since Barack Obamas 2012 re-election. Now if only one of those nearly 10K citizens knew how to update the state-party website.

[Daily NonPareil | photo: Getty]

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Scientists Have Grown the First Synthetic Self-Developing Embryo – Futurism

Posted: at 2:40 pm

The Tale of Two Stem Cells

Embryo-based research has advanced rapidly over the past few years. While scientists have developed progressive opinions regarding the ethics of gene editing and chimera embryosthe research continues to carry a large stigma due to theethical limit on embryos. We might now be able to avoid ethical dilemmas entirely thanks to the innovation of thesynthetic self-developing embryo.

A study published in the journal Sciencefeatures the external development of a mouse embryo. With the use of embryonic stem cells, developmental biologist Magdalena Zernicka-Goetz and her team at the University of Cambridge were able to replicate a living mouse embryo.

By combining genetically modified mouse embryonic stem cells (ESCs) and extra-embryonic trophoblast stem cells (TSCs) in a 3D gel scaffold, Zernicka-Goetzs team was able to drive the development of a synthetic embryo very similar to that of natural embryos. The synthetic embryo mirrored a natural embryo notonly did it form anatomically correct regions, but it also formed them at the right time. This means that the stem cells utilized are able to talk to one another to guide the specific steps of development.

The synthetic embryo cannot develop into a healthy fetuslargely due to the fact that a third stem cell would be required to develop a yolk sac, the part of the embryo that provides nourishment. The current conditions that allowthe synthetic embryo to develop are not optimal for placenta development either, closing the door entirely on a synthetic fetus. The rest of methods can be duplicated for others to emulate, however.

Many research teams in the past have tried to develop the embryo in synthetic form with limited success. Zernicka-Goetzs team introduced a 3D extracellular matrix into the equation, which made it possible for the stem cells to operate and form the synthetic embryo. The teams discovery is a promising sign for the future of embryo research.

Development in the early stages of the embryo is important to pregnancies, with more thantwo-thirds of miscarriages, linked to genetic glitches during fertilization. With the advent of the synthetic embryo, Zernicka-Goetz noted to The Guardian that researchers can conduct studies on key stages of the human development without actually having to work on embryos.

Currently, researchers are shackled by a shortage of human embryos to study, as scientists depend on donated eggs fromIVF clinics. Embryonic stem cells, on the other hand, are in limitless supply and avoid the ethical dilemma posed by donated or discarded embryos.

The teams next step is to successfully synthesize a human embryo analog they are convinced that its inception will push us forward in studying our earliest stages of development.

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