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Category Archives: Transhuman News

8 super mushrooms that you cannot pass up – Voxy

Posted: March 6, 2017 at 2:42 pm

By Yoko Inoue, founder of Shokuiku

A large variety of vegetables implemented into your daily diet is very important, but there are some vegetables we seem to skip past. Mushrooms, mushrooms are the one vegetable that some of us really love or really hate but this little baby is one superfood you should not skip past in your diet. Shokuiku have put together a list of 8 super mushrooms that you cannot pass up and this is why:

Reishi - Hailed in ancient Eastern medicine as the "mushroom of immortality" and the "medicine of kings", the Eastern world has been using Reishi for thousands of years, particularly in China and Japan. It is also used to treat certain medical conditions. The Reishi mushroom is very strong in antioxidants. It is believed to suppress the growth of tumors in people with cancer. Have anti-inflammatory properties and are therefore used sometimes for patients who have Alzheimers and heart disease. Reishi mushrooms can improve the flow of blood to the heart and reduce the amount of oxygen the heart consumes. It can help to lower cholesterol and some of the ingredients may help combat high blood pressure.

Chaga - Rather than soft like a mushroom, chaga is hard, almost as hard as wood. It is unique, nothing like common mushrooms. In fact, chaga is the most nutritionally dense of all tree growths. Known by the Siberians as the "Gift from God" and the "Mushroom of Immortality," this vibrant growth has been used by humans to support health for thousands of years. Number of studies on cell cultures show that chaga possesses antioxidant, anti-inflammatory, and immune-stimulating properties. kChaga may help treat inflammatory bowel disease (such as ulcerative colitis and Crohns disease), Chaga also shows promise as a treatment for diabetes.

Lionsmane - Lions mane is one of the more interesting looking mushrooms, showing teeth like spines, this mushroom that has been used for centuries as a traditional Chinese medicine and best known for its immune boosting properties. Lions mane has also being known to help improve memory and brain function and also can be helpful in treating anxiety and depression. There is also studies that have shown that lions mane has also being beneficial to people suffering from high blood pressure and eliminating toxins from the body.

Turkey tail - The turkey tail mushroom is one of the most common mushrooms and used as a traditional Chinese medicine. This magical mushroom is best known for its antioxidants, and believed to have great healing elements and strengthening the body against disease. Its immune strengthening components has been known that it can rebuild the immune system in people with cancer. Fighting off infection, prevents and treats the common cold and can also aid in digestion when incorporated into your diet.

Cordyceps - This is a rare, wild Chinese mushroom that grows on caterpillar larvae and other insects. Militaris variety is said to have more and better quality of spores. This fungus is known helps to combat Fatigue, it has been used to improve sexual dysfunction, Increase immunity and anti-viral properties and is being studied as a cure for cancer. Most of cordyceps on the market are grown without a use of insects and safe for vegans.

Shiitake - The shiitake mushroom is native to East Asia and famous for its rich texture and smokey flavour. Also known as "medical mushrooms" due to a long history of fighting infection, this mushroom is filled with flavour, antioxidants, vitamins and minerals. Shiitakes benefits include improving liver function, fighting antiviral infections, strengthening the immune system, improving liver functions and helping cure liver diseases.

Maitake - This mushroom native to Japan, north America and Europe. Maitake has been known as one of the most promising medical mushrooms used to treat cancer and also used to treat some of the effects from chemotherapy. It has been known for helping fight diabetes (controlling glucose levels), high cholesterol and high blood pressure. It can also be used to help maintain weight which can promote heart health.

Meshima - Grown on a mulberry tree in Japan this mushroom also known as "womens island" this has been known for its remarkable health benefits for women. It has been used to support healthy breast cells, by having extremely positive effects of treating breast cancer tumors and also prostate cancer. The mushroom is also known for stimulating the immune system. Other health benefits include anti-ageing properties, antiviral, antibacterial, and protecting the body against DNA damage.

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You’re Dead? No Problem – Undark Magazine

Posted: at 2:41 pm

In a large warehouse next to the Scottsdale Airport in Arizona, 149 patients occupy large cylinders filled with liquid nitrogen. None are alive; some are just decapitated heads. Yet to adherents of the practice called transhumanism, they arent dead either, but suspended between life and death. When the technology becomes available, the thinking goes, they will, in some shape or form, come back to life.

BOOK REVIEW To Be a Machine: Adventures Among Cyborgs, Utopians, Hackers, and the Futurists Solving the Modest Problem of Death, by Mark OConnell (Doubleday, 256 pages).

For $200,000, you can have your own body suspended there or if you opt to have only your brain preserved, the cost is $80,000. The facility in Scottsdale, the Alcor Life Extension Foundation, is one of three cryopreservation sites in the United States. (A fourth is in Russia.)

What if technology could set us free from our own mortal bodies? If there were a way to expand our mental and physical beings beyond the limitations we were born with? If we could harness science to morph our flesh and bones into a machinelike state?

In the transhumanist school of thought, these are not far out propositions. They are our future.

To adherents of the practice called transhumanism, they arent dead either, but suspended between life and death.

The history, plight, and future of transhumanism are examined in Mark OConnells first book, To Be a Machine: Adventures Among Cyborgs, Utopians, Hackers, and the Futurists Solving the Modest Problem of Death. OConnell, a Slate book columnist and staff writer for the literary website The Millions, defines transhumanism as a total emancipation from biology itself. In this thoughtful and readable book, he aims to understand the motivations of those who are guided by the belief that technology will enable humans to transcend the human condition.

In an attempt to explore what it means to think of ourselves as machines, OConnell takes readers on an all-encompassing tour, meeting artificial intelligence researchers, philosophers, brain-uploading scientists, roboticists with the Defense Advanced Research Projects Agency, and grinders (people who implant cybernetic devices into their own skin). He closes with his travels on the immortality bus with Zoltan Istvan, a transhumanist author and entrepreneur who ran for president in 2016 on the Transhumanist Party ticket. (He didnt make a dent in the election, but he claimed that winning was not the point he wanted to bring awareness to the concept of conquering death with technology, as he reported to Inverse). OConnell touches on concepts like the singularity the moment when artificial intelligence surpasses human intelligence along with mind uploading, life extension, and space colonization. He writes in an agreeable, conversational tone, offering his opinions, doubts, and fears along the way.

OConnell makes it clear that he does not fit into the subcultures he observes: In no sense was I among my people. In no sense was this my world. As a self-proclaimed interloper, he connects directly with readers who may know next to nothing about AI, but worry about its implications. Often he closes these sections with reflections about his own uneasy relationship with machines: The effects of technology on my own life were something about which I was profoundly ambivalent; for all I had gained in convenience and connectedness, I was increasingly aware of the extent to which my movements in the world were mediated and circumscribed by corporations whose only real interest was in reducing the lives of human beings to data, as a means to further reducing us to profit.

The flip side of creating machinelike humans is creating humanlike machines, and OConnell is equally fascinated by the astounding but fraught recent strides in artificial intelligence. He visits the Machine Intelligence Research Institute in Berkeley, California, to understand why AI safety has become a pressing issue. While the existential dangers of AI may seem a far-off concern, they are a preoccupation for many Silicon Valley elites, with billions in research funding from tech icons like Elon Musk and giants like Facebook and Microsoft. OConnell observes the DARPA robotics challenge to see just how far robots have evolved, what they are capable of, and what their creators envision for the future.

If transhumanism is the core subject of this book, OConnells explorations of artificial superintelligence and high-tech robotics come off as somewhat confusing detours. Transhumanism, it should be stressed, is one subset of AI not the other way around. Nick Bostrom, one of the most vocal proponents of investing in research to develop safe AI, would likely distance himself from transhumanism, as would many computer scientists and traditional AI researchers. Even within transhumanist thought, there are divides. OConnell does not fully investigate them.

Who are you when your body is part or all machine? If you could choose immortality, would you?

OConnell tries to understand the extreme branches of transhumanism that would turn brains and bodies into virtual machines. But not all transhumanists go so far. Theres a spectrum, and some of the most pressing ethical and scientific dilemmas may lie within it. What does it mean to be half human, half machine, for instance? If we could live longer by using technology to replace parts of our aging, dying bodies, would we? What about fixing certain parts of the brain with artificial replacements? Where is the line? What about the concept of Google Glass, the failed tool intended to literally attach to our line of vision, giving us intelligence in real time? These questions are current and relevant, and it would have been interesting to see OConnell engage them in more depth.

OConnell plays into the presumed fears of readers. While he is sympathetic to the pursuit of a post-human condition, he displays his own doubts. He occupies a safe space, an us versus them world in which they are misguided or outside the bounds of normal society. It is easier to look askance at Istvans extremely problematic idea of implanting microchips in Syrian refugees, to track their whereabouts and whether they are contributing to society, than to explore whether you might choose to have a nonfunctioning piece of your body artificially replaced. It would have been riskier for OConnell to dig into his own thoughts in this murky space. To resist the temptation to highlight the strangeness of his characters. To wrestle not with why they arrived at their conclusions, but with whether there are merits to these ideas. Or to let the characters speak solely for themselves. Many of these people are highly intelligent, capable, and influential; they deserve due respect for philosophies that lie outside what many consider normal.

To Be a Machine raises deep religious and philosophical questions. What does it mean to be human? Who are you when your body is part or all machine? If you could choose immortality, would you?

As OConnell himself admits, he wound up substantially more confused after writing this book. Many readers will likely experience the same mystification. But perhaps thats the point.

Hope Reese is a staff writer for TechRepublic, a division of CBS Interactive. She covers the intersection of technology and society, focusing on AI, robotics, and driverless cars.

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You're Dead? No Problem - Undark Magazine

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Man’s ‘human fly’ attempt goes horribly wrong – New York Post

Posted: at 2:41 pm

A man who was locked out of his room at a Lower East Side shelter tried to human-fly himself over to his window by jumping off a fire escape Sunday but landed in an air shaft, police sources said.

The man survived the more than three-story fall, they said.

The victim, who lives at the Bowery Residents Committee homeless shelter on Pitt Street, jumped from a fifth-floor fire escape and landed in an air shaft between the second and first floors just after 3:30 p.m., according to police.

Staff at the scene say they were trying to un-jam the mans door for him but could not keep him from heading for the fire escape.

He was trying to human-fly to his window, a police source told the Post. He wasnt thinking very logically.

Emergency responders were able to extricate him and rushed him to Bellevue Hospital. Doctors say he is expected to survive.

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Man's 'human fly' attempt goes horribly wrong - New York Post

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Human remains found inside Houston house – CT Post

Posted: at 2:41 pm

Photo: Brett Coomer, Houston Chronicle

This house on Allston Street in the Heights, where human remains were discovered in a wall on Saturday, is shown surrounded by development on Sunday, March 5, 2017, in Houston.The house was the former residence of a 61-year-old woman, who was the last holdout in the neighborhood, refusing to sell to developers who were leveling 1930s bungalows in favor of modern apartments, She went missing in 2015. The house was foreclosed, repaired and flipped and the new owners discovered human remains inside one of the walls of the home.

This house on Allston Street in the Heights, where human remains were discovered in a wall on Saturday, is shown surrounded by development on Sunday, March 5, 2017, in Houston.The house was the former

The picture of Mary Cerruti that was on a Houston Police Department Missing Persons Unit flyer in 2015. Cerruti had last been seen in the spring of 2015. (Photo courtesy Houston Police Department)

The picture of Mary Cerruti that was on a Houston Police Department Missing Persons Unit flyer in 2015. Cerruti had last been seen in the spring of 2015. (Photo courtesy Houston Police Department)

Mary Cerruti's basket holds photos of her mother and father, Ruth and Boyd Stewart, who died 35 years ago.

Mary Cerruti's basket holds photos of her mother and father, Ruth and Boyd Stewart, who died 35 years ago.

This house on Allston Street in the Heights, where human remains were discovered in a wall on Saturday, is shown surrounded by development on Sunday, March 5, 2017, in Houston.The house was the former residence of a 61-year-old woman, who was the last holdout in the neighborhood, refusing to sell to developers who were leveling 1930s bungalows in favor of modern apartments, She went missing in 2015. The house was foreclosed, repaired and flipped and the new owners discovered human remains inside one of the walls of the home.

This house on Allston Street in the Heights, where human remains were discovered in a wall on Saturday, is shown surrounded by development on Sunday, March 5, 2017, in Houston.The house was the former

This house on Allston Street in the Heights, where human remains were discovered in a wall on Saturday, is shown surrounded by development on Sunday, March 5, 2017, in Houston.The house was the former residence of a 61-year-old woman, who was the last holdout in the neighborhood, refusing to sell to developers who were leveling 1930s bungalows in favor of modern apartments, She went missing in 2015. The house was foreclosed, repaired and flipped and the new owners discovered human remains inside one of the walls of the home.

This house on Allston Street in the Heights, where human remains were discovered in a wall on Saturday, is shown surrounded by development on Sunday, March 5, 2017, in Houston.The house was the former

Broken sheet rock lies in the front yard of a home on Allston Street after new homeowners discovered a human skeleton inside a wall Saturday, March 4, 2017. The previous owner went missing in 2015.

Broken sheet rock lies in the front yard of a home on Allston Street after new homeowners discovered a human skeleton inside a wall Saturday, March 4, 2017. The previous owner went missing in 2015.

Human remains found inside Houston house

HOUSTON - The two-bedroom, steel-blue 1930s-era home is among the last few standing next to condo towers and shiny new townhomes in Houston's Heights neighborhood.

The new owners were just moving into the 1,161-square-foot house on Saturday -- the upturned soil still fresh in a row of pink, white, yellow and purple flowers in front of the porch -- when one of them shifted a board in the attic, peered down inside a wall and saw a jumble of bones.

In the rain-soaked grass, thrown into relief by the soft glow of a single porch light, a little pile of broken sheet rock looked like just another moving-day project.

"We popped a pretty good hole in the wall," Houston Police Detective Jason Fay said.

Neighbors said the remains could belong to a woman who went missing in 2015. Mary Cerruti, 61, was last seen in February or March of 2015 and is still listed as missing, Fay said. Public records show she was the previous homeowner of the $400,000 home.

According to a post on the West Heights Coalition website, police visited the home in the summer of 2015 after receiving calls about the house, but didn't find Cerruti.

"Neighbors remain hopeful that Mary will be found alive and well," the post said.

There was nothing else in the wall but a tattered rag and a pair of red-framed eyeglasses, of the $5 drugstore variety. Animals had disturbed the skeleton.

The owners called police in the afternoon, and the medical examiner's office finished extracting the bones shortly before 7 p.m. They appeared to belong to an adult, Fay said.

The new residents left after nightfall.

They were "a little worried because they have a body in the house," Fay said. "Was it someone who was killed and stuffed in the wall, or did they accidentally pass away by ending up in the wall?" It's possible the person tripped in the attic and fell into the empty space, he said.

Mark DeBoer said the home was abandoned, the lawn overgrown, with a "for sale" sign out front, since he moved to the area a few years ago. He wondered how the new owners might be coping with their discovery.

"That sort of thing is supposed to go on the seller's disclosure," he said.

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Human remains found inside Houston house - CT Post

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Italian Futurism and Fascism: How an artistic trend …

Posted: at 2:40 pm

The connection between Italian Futurism and fascism is well known. Alan Woods looks at the psychology of the Italian bourgeois and petit bourgeois intellectuals in the period before and during the First World War that gave rise to this singular phenomenon. It is an object lesson on how art and politics can become inextricably linked, and how this mixture arises from a definite social and class basis.

During my recent speaking tour of Austria, I was taken to visit an exhibition of Italian futurist art in Vienna. It was a very revealing experience. The connection between Italian Futurism and fascism is well known, but here for the first time I was able to see with complete clarity the psychology of the Italian bourgeois and petit bourgeois intellectuals in the period before and during the First World War that gave rise to this singular phenomenon. It is an object lesson on how art and politics can become inextricably linked, and how this mixture arises from a definite social and class basis.

This is not to say that the two things are the same, or that the relation between them is automatic and direct. On the contrary, the development of art, literature and music follows its own immanent laws. The development of art and politics form two entirely separate lines, with their own determining features, turning points, complex relations and revolutions. However, since all social phenomena share a common ground, the two lines frequently meet and bisect. The study of this complicated and dialectical interrelationship would be a fascinating but difficult exercise. It is not often that the connection can be clearly established. But in this case it is quite transparent.

Futurism arose as part of the general artistic ferment that characterised the intellectual life of Europe, and particularly France, in the period before 1914. This was a period of spectacular advance of capitalism, which was developing the productive forces at a dizzying pace. Europe and the USA were industrialising rapidly. Industry was advancing at the expense of agriculture, the proletariat at the expense of the peasantry. Old ideas were crumbling. In the field of science the basis was being laid for a twin revolution, connected with relativity theory and quantum mechanics. The human mind was gradually penetrating beyond the world of appearance and discovering a deeper reality in the sub-atomic world, where the laws of the ordinary world of sense perception do not apply. The sensation existed that this was a new age, an age of progress in which the machine was king. Out of this idea arose the cult of the modern.

Britain and Europe before 1914

When the new generation of artists raised the standard of revolt against the old conservative style of academic art they were reflecting this new spirit. This ferment and clash of ideas and schools indicated a profound current in the intelligentsia of the main countries of continental Europe. The exception was Britain, where the new trends were weakly represented, if they were represented at all. This difference was no accident. At the commencement of the 20th century, British capitalism still enjoyed a crushing superiority over its rivals. Its industry ruled supreme in world markets as its warships ruled supreme on the high seas. It presided over an empire on which the sun never set, as they boasted in London.

The super profits from this privileged position created a feeling of quiet self-satisfaction and superiority over less fortunate nations. The psychology of the British ruling class was cast in stone in Tower Bridge, surely the most remarkable bridge that has ever been built. It resembles not a bridge but a cathedral. Here is a statement of a ruling class that was firmly convinced that it would dominate the world for a thousand years! It is no accident that this celebrated monument, built at the threshold of the 20th century, is purely medieval in style.

The outlook of all classes in British society was shaped by the special position of British capitalism in the world. The super profits derived from its colonies and its domination of world trade, allowed it to give concessions to the middle class and part of the working class. Reformism was the dominant tendency, first with the Liberal Party of Lloyd George and later with the young Labour Party. The British Labour movement, unlike its cousins in continental Europe, was characterised by a lack of any theory. In general, the Anglo-Saxon mentality is averse to broad theoretical generalisations of any kind, preferring to muddle through on the basis of what is known from past experience.

This is the basis of Anglo-Saxon empiricism and pragmatism. It is a tradition that could only arise from a privileged economic position that does not place any serious demands on the intellect. It breeds a generally conservative outlook that regards the present situation as eminently satisfactory and encourages a kind of vulgar evolutionism that imagines that tomorrow will always be better than today. Such an intellectual background is unfavourable to bold and imaginative thought in general. It is profoundly anti-dialectical, holding fast to the belief that nature does not make leaps. Only great historical events could shake this smug and superficial view of the universe.

The relative poverty of artistic development in Britain at a time when its continental neighbours were in a state of violent intellectual ferment can only be explained by the insularity of the British at a time when everything seemed to be for the best in the best of all possible capitalist worlds. At a time when the French were overthrowing the old academic art, in Britain it was firmly entrenched. The British Pre-Raphelite school of art that pretended to be modern was really a conservative trend that looked backward, not forward. When compared to the new developments in European art, it seems merely quaint and provincial. Here we look in vain for anything new or revolutionary. While composers like Debussy and Ravel, Stravinsky, Bartok and Prokofiev were experimenting with a new musical language, Elgar was still writing symphonies in a style that looked back to the world of the 19th century.

There are some signs of life in the works of Beardsley, but in general there was little or no innovation. Insofar as there was anything new it was imported either from France or from Englands oldest colony, Ireland. In literature, it is no accident that the most important writers were all Irish: Oscar Wilde, Bernard Shaw, and above all that great genius, James Joyce. As for the wretched Bloomsbury Group of writers and artists, they never rose beyond the level of provincial English middle class second-raters, whose well-merited epitaph was written by the American poet Ezra Pound:

O bury me not in Bloomsbury

Where the gravy tastes like the dust.

Ferment in France

The striking contrast between the intellectual life of Britain and France before the First World War is explained both by the different traditions of the two countries and their recent history. British capitalism developed organically over several centuries. Its evolution was slow and gradual. All the stages of capitalist economic development can be clearly seen in England from the 14th century onwards. That is why Marx always took England as the classical country of capitalism from an economic point of view, while France was taken as the classical capitalist country from the political standpoint.

The history of modern France begins with the French Revolution of 1789-93, and continues through the revolutionary and Napoleonic wars, through the Bourbon reaction after 1815, the Revolutions of 1830 and 1848, the Bonapartist reaction that followed the defeat of that Revolution, then the Franco-Prussian War of 1870-71 and the glorious episode of the Paris Commune, the first time the proletariat ever took power in any country. The defeat of the Commune led to a long period of reaction, interrupted by the Dreyfus scandal that brought France to the brink of civil war in the last decade of the 19th century.

These stormy decades of war, revolution and counterrevolution created an environment for the artists and intellectuals that was very different from that of Britain. France was perhaps the most politicised society in Europe, and this fact affected the outlook of the French artists and writers. Not for nothing was Paris considered the hub of intellectual life for the whole of Europe in the second half of the 19th century and the beginning of the 20th century. Art and revolution repeatedly linked arms and fought together, laughed and cried together, rejoiced and suffered together.

Of course, the relationship was not a direct or simple one. But anyone with the slightest knowledge of the history of French art and literature in the 19th century will be well aware that the relationship was very real and played a vital role. In complete contrast to the intellectual and artistic conservatism in Britain, Paris was a bee-hive of intellectual inventiveness and innovation. New schools of art, literature and music arose, each with its defenders and detractors. They argued, fought, wrote rival manifestos and organised the artistic equivalent of political tendencies and parties.

After Impressionism, Fauvism and Pointillism came Cubism, Dadaism and Surrealism. This was the Paris of Picasso and Satie, Stravinsky and the Ballets Russes. It was a world of chaos and turbulence, of constant movement and change that mirrored the revolutionary changes brought about by capitalism in the early years of the 20th century and that represent the starting point for Futurism.

The emphasis on the barbaric was one element in this movement. We find this in music with compositions such as Bartocks allegro barbaro and Stravinskys The Rite of Spring. The violence with which the defenders and critics of the new art and music fought each other is shown by the disturbances that regularly occurred in theatres and concert halls in these years. At the first performance of Stravinskys revolutionary ballet The Rite of Spring in 1911 a riot broke out in the theatre, with one section of the audience booing and protesting and another applauding wildly. This was a fairly common occurrence. All this showed at least that art was alive and kicking. It still had the power to shock and awe, and to provoke powerful emotions, for and against. Art aroused passion, in a way that it no longer does today.

How does one explain this passion? It reflected a definite mood in a layer of society - the intellectuals. The intelligentsia, contrary to their own belief, cannot play an independent role in history. But they do provide a most sensitive barometer of certain moods that are building up in the deepest recesses of society. This means that certain trends among the intellectuals, students and so on, can sometimes anticipate processes that will occur later in the whole of society. The wind blows through the tops of the trees first. Thus, the movement of the French students in May 1968 was the first indication of the revolutionary general strike of the working class that followed it. The students did not cause the movement of the working class - they anticipated it. We have seen this many times in history.

The ferment among the intelligentsia appeared like a froth on the surface of what was otherwise a sea of stagnation. It was against this complacent stagnation that the artists and intellectuals rebelled. This rebellion did not in itself represent a reflection of existing social revolt, but it did express the accumulation of deep tensions and unresolved contradictions in society. It was a kind of heat lightening that precedes a storm. That storm finally burst in the summer of 1914 when history finally presented its bill to the western world.

Futurism and Cubism

The rapid rise of industry and the widespread application of new technology captured the imagination of the new generation of artists who rejected the stale conventionalism of the Academy. The cult of the machine was central to Futurism. Cubism had already started to represent reality as a series of geometrical forms. Futurism took this one step further, elevating the straight lines and streamlined forms of industry to a new form of art.

The first Futurist exhibition was held in Paris in 1911, but it originated in Turin in March 1910 and was associated with the work of F.T. Marinetti. It advocated the renovation of Italian art and declared that art could live only by emancipating itself from the dead hand of the past. It repudiated tradition, academic training, museums, picture galleries and the art of previous ages. All these things were regarded as so many fetters on the development of art.

Marinetti experimented with new literary forms that attempted to express emotions directly to the eye of the reader through the use of different types, suggestive arrangements of spacing and lines and other devices that were later developed by Mayakovsky and the Russian Constructivist artists after 1917.

According to the futurist manifesto, a picture must be a synthesis of what one remembers and what one sees. Thus, a futurist painter would paint not only what he saw before him but would combine this information with the recollections of previous scenes that lingered in his mind. Objects and persons were studied from all sides so that every aspect would be represented - visible or invisible, front and back. The original futurists were Marinetti, Boccioni, Carra, Russolo, Balla and Severini.

In its initial stages Futurism was really an offshoot of Cubism. Many of its earliest productions could almost be mistaken for Cubist paintings. Futurism began as a specifically Italian variant and development of Cubism. The Futurists, in common with the Cubists, rebelled against the artistic Establishment and the 19th century. They looked for new themes, and found them, not in the mists of the past, but in the present - and in the future. Their art was based on the cult of the modern. Whereas the 19th century Romantics recoiled in horror from the age of the machine, the futurists embraced it with enthusiasm. The machine forms an important element in this art.

As with the Cubists, the objects of the everyday world are reduced to geometrical forms - lines, squares, triangles, cubes - but there is a new ingredient that links this tendency to the forms of industry - machines, locomotives, cars - that express the idea of speed and motion. There is something vibrant in this art, a sense of restless movement and urgency. Giacomo Balla produced a series of striking black and white paintings depicting motor-cars and trains in motion, all conveying the idea of speed. He uses such titles as Lines of Speed to convey his intentions. This art is quite effective in conveying the idea of life in the fast track. It is exciting and exhilarating. It grabs you by the collar and shouts at you: No to stagnation! We must not stand still! Speed! More speed!

Futurism and imperialism

This infatuation with speed, change and modernity tells us a lot about the mentality of a layer of the radical petty bourgeoisie in Italy during the first decade of the 20th century. The unification of Italy in the 19th century created the conditions for the emergence of Italy as a European power. It opened the prospect of the rapid overcoming of its age-old backwardness and its transformation into a modern capitalist economy. For a generation raised on the idea of Italys once and future greatness this was an intoxicating prospect.

But there was a problem. The belatedness of Italian capitalism meant that it had come too late onto the stage of history. The world had already been divided up between the older capitalist powers, first Britain and France, and then Germany. The ambitions of weak Italian imperialism were thwarted on all sides by powerful neighbours. Its colonial ambitions were limited to miserable pickings such as Albania, Libya and Ethiopia. This bred a sense of frustration and resentment among the nationalist youth that was fertile ground for the rise of imperialist, militarist and fascist tendencies.

Here we see the reason for the striking contrast between the cultural atmosphere in Britain and the rest of Europe. The British middle class had been provided with careers, good wages and a privileged position through the empire and its vast colonial civil service. They saw no reason to be dissatisfied with the existing state of affairs, and this sense of smug self-satisfaction found its expression in the cultural world on this side of the Channel. The British intellectual, like the British democratic politician, was naturally conservative and backward-looking. In both cases, it fed upon the fabulous wealth plundered from the colonies. British culture, like British parliamentary democracy, were the products of a wealthy country that lived off the backs of millions of colonial slaves.

But the world seen through the eyes of the Italian bourgeoisie and petty bourgeoisie presented a very different aspect. The imperialist wing of the Italian bourgeoisie did not wish to conserve the existing world order, but destroy it. The demand for change that was so urgently expressed in Futurist art was simply a semi-conscious reflection of this fact. It was an artistic expression of the feelings of impotent rage, fury and a desire to overturn the existing order, not only in the world of art but in the real world. That explains the ease with which Italian Futurism became merged with imperialism and its most extreme expression - fascism.

Italy had established its position among the nation states of Europe too late to participate in the division of the spoils of successive wars. Its development was hampered by the lack of colonies and foreign markets. Out of this fact came the urgent demand for a fair share of the world for the expansion of Italian capitalism. Imperialism and an aggressive colonial policy was a natural consequence of this.

Conscious of a glorious but distant past, a layer of Italian intellectuals dreamed of rediscovering the splendours of imperial Rome. But Italian capitalism had come to late onto the stage of history for these dreams to become a reality. Italy was hemmed in on all sides by powerful enemies: Austro-Hungary which blocked her on the Balkans, France, which blocked her in North Africa, Germany which made her exports uncompetitive. The only way to break out of this suffocating condition was through war. War was not something to be afraid of or deplore, in the manner of feeble pacifists, but a glorious adventure, a necessary condition for the material and spiritual rebirth of the Italian people. War was something to be glorified in art.

In 1915 Marinetti, the founder of Italian Futurism, published a book with the title La Guerra - Sola Igiene del Mondo (War - the Sole Hygene of the World). Here we have the distilled essence of imperialism - the notion that wars are a necessary means whereby humanity overcomes stagnation and purifies itself through fire. This adequately conveys the delirium of the Italian imperialist petty bourgeoisie who greeted the horrors of the First World War as one would welcome the invitation to a party.

Later on this dream of the Italian imperialist petty bourgeoisie turned into a nightmare. But in the years that preceded the great imperialist slaughter of 1914-18, it acted as the mainspring of the main trend of Italian art. From the beginning, futurist art was impregnated with a spirit of suppressed violence and aggression. Here in paint we see the concentrated expression of the pent-up rage and frustration of the Italian imperialist petty bourgeoisie. The slashing lines that criss-cross these abstract paintings are like the tracer bullets that light the sky over a battle at night-time. The jagged edges speak of lacerations. The whole thing is filled with an explosive element that anticipates war, upheaval and conflict.

In the world of Futurism the machine is god. The human disappears completely. This is really a preparation for the totalitarian state where the individual is completely at the service of the imperialist state and the military machine. Machinery, of course, has many applications, most of them of a socially useful character. But in the epoch of monopoly capitalism and imperialism machinery has as its highest purpose the production of armaments for the purpose of dividing the world between different groups of robbers. And the highest function of people is to act as meat for this huge mincing machine. This crude reality of imperialism is where the Futurist dream ends up.

The class basis of Italian Futurism

Not everything was grim in the Futurist movement, however. It also had its lighter side, as befits an Italian movement. Fortunato Depero was one of the clowns of the Futurist movement. His paintings have e lighter, more frivolous side that is missing from most of the others. Most of them took themselves very seriously - as did the biggest clown of all, Benito Mussolini.

Common subjects of early futurist art were caf life and sex. Later the subject changed to war, which they glorified. The early subject matter reflects the life style of the futurists themselves: here is the mode of existence of the spoilt bourgeois brat, the playboy and the wealthy drone. Their other interests reflect the same thing. They designed smart clothes, including gaudy waistcoats, ties and caps for the young peacocks.

A few generations earlier, the young Gautier wore dazzling red waistcoats when he participated in riots at the theatre - but that at least had revolutionary implications. Gautier belonged to another epoch - the epoch of Romanticism, when the rebellious bourgeois youth were fighting against the manners and values of the bourgeoisie and striving to return to the revolutionary ideals of 1789-93.

In the first half of the 19th century the youth of Italy found a revolutionary cause in the struggle for national liberation against Austria. But having achieved power, Italian bourgeoisie immediately gave all the signs of senility. As frequently happens, the bourgeoisie of a formerly oppressed colony became an aggressive imperialist bourgeoisie after coming to power. The pampered sons of the Italian rich, the gilded youth as they were known in post revolutionary France, later provided the shock troops of Mussolinis Blackshirts in their brutal assaults against peasants and trade unionists. The psychology of this social stratum is clearly revealed in this art.

In Literature and Revolution, Trotsky writes: Futurism originated in an eddy of bourgeois art, and could not have originated otherwise. Its violent oppositional character does not contradict this in the least.

The intellectuals are extremely heterogeneous. At the same time, each recognized school of art is a well paid school. It is headed by mandarins with their many little balls. As a general rule, these mandarins of art develop the methods of their schools to the greatest subtlety, while at the same time they use up their whole supply of powder. Then some objective change, such as a political upheaval or a social storm, arouses the literary Bohemia, the youth, the geniuses who are of military age, who, cursing the satiated and vulgar bourgeois culture, secretly dream of a few little balls for themselves, and gilded ones, too, if possible.

When investigators define the social nature of early Futurism and ascribe a decisive significance to the violent protests against bourgeois life and art, they simply do not know the history of literary tendencies well enough.

What we have here is the expression in art of the striving for power of the weak Italian bourgeoisie and particularly the impotent petty bourgeois intelligentsia. As the sick Nietzsche glorified health and strength and projected his longing into the idea of the Superman, so the feeble Italian petty bourgeoisie expressed its burning and impossible desire to be strong. They longed for power, but in the end were only the lackeys of the big capitalists they pretended to despise. This is the eternal contradiction of the petty bourgeoisie, which imagines that it is a power but in reality is obliged to choose between the rule of the proletariat or that of the banks and monopolies. And the big capitalists made use of the fascist demagogues to get control of the plebeian masses.

The petty bourgeoisie - the discontented peasant, the ruined shopkeeper and the frustrated government clerk, fall under the influence of the right wing intellectuals, the pampered sons of the rich, the golden youth whose restless and adventurist spirit finds an outlet in extreme and belligerent patriotism. Disappointed chauvinism in turn fuses imperceptibly with fascism. Italian Futurism is transformed into art in the service of fascist reaction and Mussolinis corporate state.

Futurism and Fascism

In the beginning, the highly combustible mood that underlies this art could be mistaken for a revolutionary feeling, and in fact it reflects a revolutionary trend insofar (and only insofar) as it rejects the status quo. This art is a slap in the face for existing society, its aesthetic norms and values. It announces the immanent end all that is: it proclaims that all that present society regards as sacred and valuable is based on a rotten foundation. This foundation must be dynamited, blown sky high, in order that the creative spirit of the people should be liberated. What began as an artistic message - the rejection of stagnation and inertia in art - now becomes a clearly political message. Not just the old art, but all the other manifestations of the old society must be overthrown.

In some ways the futurist point of view comes close to the ideas of Bakunin - the idea that before we can build a new society it is first necessary to destroy. In the exhibition there is even a painting done by a Futurist artist before 1914, of the funeral of an anarchist, which implies a certain sympathy with the latter. This is not as surprising as it may seem. The class basis of both movements is, in fact, quite similar, although their programme and aims are diametrically opposed. Anarchism reflects the psychology of the revolutionary left wing of the petty bourgeoisie and also, in part, the lumpenproletariat. Its real model is that of plebeian revolt against the existing order. This idea would also have appealed to the Italian Futurists. In both cases it represents a petty bourgeois, not a proletarian, view of revolution. In Italy the standpoint of the petty bourgeois revolutionary has, after all, a long tradition, going as far back as Mazzini and Garibaldi.

Whereas Marxism, the ideology of the proletariat, has a scientific conception of the class struggle and revolution, anarchism represents an inconsistent and incoherent standpoint that confuses revolution with the kind of unorganised revolt of the masses, in which the working class is only one element, and not necessarily the decisive one. No difference is made between the different strands of the oppressed - workers, peasants, unemployed, ruined petty bourgeois, students and lumpenproletarians - are all subsumed under the category of the masses.

Of course, fascism and anarchism are opposite extremes. Fascism is a mass movement of the petty bourgeoisie and lumpenproletariat that serves the interests of imperialism and the big banks and monopolies. But in order to enlist the support of the masses, it must disguise itself with radical and socialist demagogy. Within the fascist movement there is always a radical wing, associated with the lumpenproletariat, that takes this demagogy seriously. These elements dream that the fascist revolution will indeed overthrow the old society and hand power to the masses (i.e., them), giving them freedom to rob and plunder society at will. Needless to say, this wing is always crushed when the fascists take power. In Germany this wing was represented by the SA, in Italy, the Blackshirt banditi.

This radical demagogy is reflected in some Futurist paintings, which purport to describe the working class. However, it is immediately evident that this is a purely abstract conception of the workers, as seen from a distance, or, more correctly, from on high. The artist has not the slightest knowledge of real workers, how they live or what they think. They are merely idealised generalisations. The muscular figure of an Italian port worker shown in the exhibition is completely anonymous. Here the worker is glorified as an ideal machine for the production of surplus value. He has no individuality. He is merely a unit in the impersonal collective that serves the greater glory of Italy - that is, the greater glory of the Italian bankers and capitalists.

Where the masses are shown in a revolutionary context, they are equally anonymous. The painting called The Revolt by Luigi Russolo (1911) depicts a red wedge, driving irresistibly to the left, and smashing through a solid barrier. The colours are stark and violent - red, yellow, blue, green and purple. The central idea is that of conflict and violent antagonism: one force clashes against another. But the masses are depicted as a blind and unconscious crowd, carried forward irresistibly by an unseen impetus. Here the revolution appears not as the conscious activity of the working class, but as the movement a dumb herd. This fits in perfectly with the subjectivist ideology of fascism, which treats the masses as an inert material to be moulded and organised by the Leader. In this conception, the old idea of crowd and hero is resurrected in a fantastic and reactionary form.

The elements of a fascist and imperialist ideology were present in embryonic form in Futurism long before it erupted fully formed onto the stage of politics. After 1918 the disappointment of the Italian petty bourgeoisie with the results of the First World War gave rise to the fascist movement, led by the former socialist Mussolini. The mass basis of fascism is the same in all countries - the petty bourgeoisie and the lumpenproletariat. In the stormy period 1919-1921, the future of Italian society was posed in the starkest terms - either or. The workers struck, set up soviets and seized the factories. The socialist revolution was on the order of the day. But the reformist leadership of the Socialist Party hesitated and drew back. The initiative passed to Mussolini and the fascist blackshirts. Mussolini organised the notorious march on Rome. The mass of ruined petty bourgeois and lumpenproletarians, funded by the Italian bankers and capitalists, were organised and mobilised as a battering ram to smash the workers organisations, to burn, terrorise and murder.

A reactionary dead end

There is a portrait of the father of Italian Futurism, Tommaso Marinetti by Enrico Prampolini, painted in 1924, where Marinetti appears as a kind of snarling monster - a demagogue with red eyes, rather in the manner of Mussolini. If this is meant to be a vision of the future, then it is a nightmarish vision. Whether consciously or not, it is quite an accurate portrait of its subject. Ultimately, this art terminates in a dead end, like the political philosophy it so eagerly espoused.

Whereas before 1914 Italian Futurism had a certain raw energy and even semi-revolutionary overtones, after the coming to power of Mussolini it loses all its rebelliousness and places itself totally at the service of the state. From this time on it loses all interest as an artistic trend. The Futurists, eager to please their fascist masters, produced extravagant models of grandiose public buildings in the Futurist style, but very few were actually built. What Mussolini needed was to devote all the energies of the Italian people to the preparations for a new war. Art was not high up on his list of priorities.

The essential goal of fascism is to destroy the embryo of the new, socialist, society that has been developing in the womb of the old society. It aims to crush the labour movement, the trade unions, the workers parties, the co-ops, because without these organisations the working class is only raw material for exploitation. An unorganised and atomised working class would be completely at the mercy of Capital. Shorn of all its demagogy and mysticism, that is the essence of a fascist regime. Fascism represents a monstrous regression of culture and civilization and a new form of slavery. The individual is a slave of the corporate state, which is really an instrument for the defence of the rule of the banks and giant monopolies, although the fascist gangsters sometimes take measures against the class they represent.

This merging of Futurism with fascism after 1918 is so rapid that it seems to flow from the very essence of Futurism itself. But this conclusion would be too simple. In Russia, Futurism took precisely the opposite direction and placed itself at the service of the October Revolution. The great Russian Futurist poet Mayakovsky joined the Bolshevik Party before the Revolution and remained a Bolshevik until his tragic suicide in 1931.

The reason for the difference between Italian and Russian Futurism is not to be found in art (broadly speaking they shared a common artistic view) but in the different objective conditions of Russian and Italian society. Whereas the Italian bourgeoisie had already fulfilled its progressive mission in the unification of Italy, in Russia the bourgeoisie was incapable of playing any kind of progressive role. Only the coming to power of the working class by revolutionary means could clear away the accumulated rubbish of feudalism and open the way to further development through a nationalised planned economy. Therefore the most progressive elements of the Russian artists and intellectuals gravitated to the camp of revolution. The left wing predominated.

The prevailing mood among the Italian artists and intellectuals before 1914 was entirely different. They had illusions in the recovery of Italian greatness through war and imperialist expansion. The dominant trend (though not the only one) was therefore not revolutionary but chauvinist and pro-imperialist. This was considerably helped by the fact that none of these people had the remotest idea of what war was really like.

From its earliest beginnings there was always a tendency in this art to glorify violence. Marxists do not glorify war and violence. That is as senseless as to deplore the existence of war without explaining its real meaning, origins and content. We recognise the simple fact that violence can be used for revolutionary and progressive ends or reactionary ones. Few people would question the progressive nature of the war waged by the armies of the Abraham Lincoln against the slave-holding Confederacy in the Southern states of the USA, or the wars to unify Italy, and we consider the October Revolution to be the greatest act of social emancipation in history. But art that glorifies imperialism advocates a destructive and reactionary violence and has no progressive content whatsoever.

Likewise, the rejection of the existing order is an idea that can be filled with a reactionary as well as a progressive content. Marxists criticise the existing formal bourgeois democracy because of its merely formal character, behind which lurks the dictatorship of the banks and big monopolies. We advocate the replacement of formal bourgeois democracy by a genuine democracy of the working people, which is only possible through the expropriation of the banks and monopolies by the conscious action of the working class. By contrast, the fascists stand for the abolition of bourgeois democracy and its replacement by the open dictatorship of big capital. That is to say, our rejection of the existing order proceeds from mutually exclusive premises and leads to diametrically opposed conclusions.

Fascist art - like totalitarian art in general - can never be great art. In order to flourish art, literature, music and science need the fullest freedom to develop, to experiment and to make mistakes. These branches of human knowledge can never flourish when regimented, censored and subjected to petty surveillance by ignorant bureaucrats. The art of the futurists, which in its initial phase showed great promise and vitality, under the fascist regime degenerated into mere propaganda and another arm of the corporate state. It vanished with the collapse of the latter at the end of the Second World War.

Fascist art is inhuman art because it reduces man and women to the level of cogs in a machine. This is an expression of the alienated relations of people under capitalism, where men and women are always subordinated to things - whether machines, bureaucracies or money. People are systematically stripped of their human identity and become transformed into abstract entities: either producers or consumers or taxpayers - that is: a repository of surplus value, a factory hand, a stomach, a machine for bearing children, an electoral statistic, or anything else except a living human being.

The worship of the machine in Futurist art conveys this same idea: that the human being is subordinated to machines. That is a fact in big modern factories, as Charlie Chaplin showed us in his great film Modern Times, and as any Fords production worker will tell you today. This is a part of the phenomenon of alienation under capitalism. This alienation changes its forms constantly, but it always remains the same. The development of modern techniques does not abolish the alienation but only reproduces it on an immeasurably vaster scale than ever before. The invention of things like the laptop computer, bleepers and mobile phones places the worker at the disposal of the boss twenty four hours a day.

Fascist art is based on a glorification of this alienation. It is presented as the future, and as a goal we must all strive for. Thus, under the guise of rebelling against the status quo, this art shows itself to be reactionary and conservative in its essence.

The aim of socialism is to eliminate this alienation by eliminating its material basis. Socialism represents the highest stage of human development - a genuinely free society in which men and women will be free to develop their inherent potential to the fullest extent Under socialism art and all kinds of culture, freed from the fetters of the market economy, will flourish as never before, drawing nourishment from all the riches of the past while pointing the way forward to even greater conquests in the future.

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NASA Wants Private Missions to Give It a Ride to Mars – Futurism

Posted: at 2:40 pm

In Brief

NASA made a recent public request. They stated that they were looking for opportunities to hitch a ride on non-NASA missions to Mars. This might sound strange at first, but it makes sense. NASA is not the only agency launching and planning to launch missions into space, and bringing smaller NASA experiments aboard privately owned ships could allow for quicker advancements in research. NASA, along with many others, has ambitious plans of eventually sending manned missions to Mars. However, in order to further our explorations into space, we must first have more information.

Relying only on the data provided by NASA missions would slow progress. Partnering with private agencies like SpaceX would not hinder any privately-funded research, it would only add to the amount and type of information gathered.

NASA has big plans for the future. They have done extensive research into the possibility of terraforming Mars, had astronauts simulate living on Mars for an entire year, and continued planning unmanned missions to the Red Planet in order to learn more. There has even been recent discussion of creating an artificial magnetic field around Mars in order to terraform it over time and make it habitable for humans.

There is a lot of work ahead if NASA wants to put humans on Mars and, hopefully, one day terraform the planet. While there have been successful unmanned missions from NASA and other organizations, joining forces will allow for this progress to accelerate for the benefit of all parties involved. This wouldnt be a merger of institutions, but rather a smart way to combine resources and eliminate waste. More frequent research on Mars will lead to better science and more informed space exploration. And, as scientists continue to develop the best ways for us to exist on the Red Planet, it is important that we better understand the mysteries of Mars.

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This Decatur company is taking humans to space – The Decatur Daily

Posted: March 5, 2017 at 3:51 pm

United Launch Alliance this year will begin assembling the Atlas V rocket that will boost two astronauts to the International Space Station, a spokeswoman said last week.

The project, to be handled at ULA's Decatur manufacturing plant, is part of NASAs commercial crew program, a plan to end American reliance on Russia to ferry astronauts to and from the space station 249 miles above the Earth. Since the retirement of the space shuttle in 2011, all astronauts have been delivered via Russian Soyuz spacecraft.

We are bridging history as we prepare to launch American astronauts again, ULA spokeswoman Lyn Chassagne said. John Glenn became the first U.S. astronaut to orbit the Earth after being launched on a heritage Atlas LV-3B rocket.

From raw material to launch, construction of an Atlas V typically takes about 18 months, according to Chassagne.

When the rocket finally flies, it will be the first to carry Boeings new CST 100 Starliner Capsule, which is still in development.

The capsule is slightly larger than an Apollo command module and will be able to carry crews of up to seven to the ISS as well as to private space stations once in service.

After a test flight in June 2018, the capsule is slated to take two astronauts to the ISS in December 2018, launched into space by the Atlas V assembled in Decatur.

ULA marked the successful launch of a National Reconnaissance Office satellite on Wednesday via an Atlas V from Vandenberg Air Force Base in California. It was ULAs second launch of the year. Two more ULA launches are planned this month, both from Cape Canaveral, Florida.

Work on the commercial crew program is not ULAs only current endeavor into manned space flight. ULA is slated to deliver to Cape Canaveral this month the Interim Cryogenic Propulsion Stage, or ICPS, for NASAs new Space Launch System.

Constructed in Decatur, the ICPS will serve as the second stage for the maiden flight of the Space Launch System, or SLS, slated for November 2018. That flight was intended to be an unmanned test mission around the moon using the Orion spacecraft that eventually will carry astronauts to Mars.

But NASA announced last month it is studying options for adding crew to that mission, which will require certifying the ICPS for human flight. The ICPS is a converted upper stage from a ULA Delta IV, which was not designed for manned space flight.

James Muncy, founder of the space policy consultancy PoliSpace, said last week that adding crew would likely delay that launch until after the Starliner launch, noting the life-support system for the Orion capsule wasnt slated for completion until 2021.

He anticipated few problems rating the ICPS of the Atlas V for human flight, which mainly involves analysis and very few changes to its hardware or software.

Neither Atlas V nor Delta IV are intrinsically human rated, but the Atlas V is easy to human rate, and ULA has been working on modifications to it since 2010 as part of the commercial crew program. But both vehicles are very reliable, he said.

A scaled-up version of the SLS with 143 tons of lift capacity is expected to be the launch system that eventually takes astronauts to Mars.

A ULA competitor could still be the first domestic rocket to take Americans to space since the retirement of the shuttle.

California-based SpaceX is slated to fly its new Dragon 2 capsule in May 2018 after an unmanned test flight in November of this year. That capsule is also part of NASAs commercial crew program to serve the ISS.

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CRISPR gene editing tech brings countless opportunities and challenges – Arizona Daily Wildcat

Posted: at 3:50 pm

Ian Green | The Daily Wildcat

Dr. Thomas Doetschman, Ph.D., examines the embryonic cells used to study and implant mutated and disease genes; if the mutated gene successfully imbeds itself into a sperm or egg cell, the resulting rat that is born will be studied to research the effects of that same disease genes in humans. CRISPR CAS9 is technology that allows the splicing of genes to both remove and replace particular DNA strands. CRISPR can affect either just the patient or his descendants as well, depending on the technique used.

Published Mar 5, 2017 6:00am

A new genome editing technology known as CRISPR has the potential to revolutionize the way scientists study diseases and genetics.

I think its a really useful tool for science, in fact its sort of revolutionizing the speed at which we can accomplish certain things in the laboratory and it has tremendous potential for therapeutic applications, said Kimberly McDermott, a research associate professor of medicine and an associate professor of cellular and molecular medicine, cancer biology and genetics.

Clustered Regularly Interspaced Short Palindromic Repeats, or CRISPR-Cas9, is based off a bacterial immune system, said Thomas Doetschman, professor of cancer biology, genetics and cellular and molecular medicine.

When bacteria become infected by a virus, they take pieces of the viruss DNA and incorporate it into their own genome. This allows the bacteria to recognize and attack the virus if it ever appears again. This system allows them to destroy the virus, but it also allows them to destroy DNA, Doetschman said.

In developing CRISPR, scientists took a hint from the bacteria.

What it [CRISPR] actually does is causes a mutation at that site, in the DNA, and then repairs it, Doetschman said. And you can repair it in different ways, such that you can actually modify the sequence of the DNA.

This has enormous implications for the study of genetics and combating human diseases. And while it may sound exciting, human gene editing isnt all fun and games.

There are two ways the CRISPR technology can be used in humans, Doetschman said. The first way is to alter somatic cells, which dont get passed down to the next generation. This would only affect the patient who is receiving the treatment.

The second way, known as the germline, can have serious long-lasting effects. Altering genes in the germline can produce permanent changes in the patient that will then be passed on to their children.

Theres two completely different ways of doing this, and the real concern, the big concern, is that it be used by some unscrupulous people to try to change the germline of people, so that you can create progeny that will all have this kind of modification, Doetschman said.

And CRISPR isnt just for humans; it can be used to edit plant cells as well.

It could alter genes in a plant so that the plant either becomes resistant to or susceptible to agents that might otherwise kill the plant, Doetschman said. This could mean disease-resistant plants or increased nutritional content.

One of CRISPRs greatest contributions is in the realm of research, specifically for understanding normal development and disease processes, McDermott said.

For example, in the future scientists may be able to grow human organs from the patients own cells, using CRISPR.

RELATED:Beefy bugs: antibiotic-resistant bacteria pose threat to health

Recent studies on mice and rats have introduced the possibility of using a model organism, such as a pig, to grow human organs, McDermott said.

Another exciting possibility available through CRISPR involves induced pluripotent stem cells, Doetschman said. This process essentially works as a time machine for your cells.

Doetschman describes it as the ability to put your own cells, such as skin cells, in culture and de-differentiate those cells back down to the pluripotent "master key" stem cell, using CRISPR. Once your adult cells are transformed into stem cells, you can make the genetic modifications you'd like, such as correcting a mutation and then re-differentiate the stem cells back into the cell type of the tissue you want to correct.

These cells could potentially be engrafted back into the patients disease tissue, Doetschman said.

Dr. Thomas Doetschman, Ph.D., describes a few of the many functions performed in the workspace pictured, which can effectively seal itself to create a sterile and airtight environment in which researchers can operate. CRISPR technology may redefine the future of genetics.

When it comes to working with human therapeutics, safety and regulations are extremely important, McDermott said. As scientists, their primary concern is to minimize and prevent harm in every way possible.

One of these regulations is a patent that was recently issued to the MIT and Harvard-affiliated Broad Institute, one of the centers responsible for creating CRISPR technology.

RELATED:UA researchers win NIH grant for autoimmune disease work

Despite heavy public controversy surrounding the patent, Doetschman said the patent is a good thing, because it will allow scientists to ensure that CRISPR research is carried out in a safe way, especially in regards to human use.

I think from a scientists perspective, the thing that were really focusing on is trying to listen to our colleagues but also the public in general about what are the fears of this technology, McDermott said. Of course when you start to edit genes and mutate genes theres a lot of concerns about what might happen.

As for the future of human genetics research, both Doetschman and McDermott remain optimistic.

While scientists may have had the ability to make mutations in cells in the past, the results were usually inefficient and could produce off-target effects, McDermott said. CRISPR improves both the efficiency and the accuracy of genome research.

CRISPR might not be the cure to every disease, but it is the key to unlock many avenues of research, Doetschman said.

In terms of the research end of science and medical research, its expanding tremendously the scientists ability to ask questions about genetic disease, Doetschman said.

Doetschman currently uses the CRISPR technology to study mice in his lab on campus. You can readabout his research here.

Follow Hannah Dahl onTwitter.

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A mysterious medical condition gets a name – and a genetic link to deafness – Reading Eagle

Posted: at 3:50 pm

Special To The Washington Post.

He loves dancing to songs, such as Michael Jackson's "Beat It" and the "Macarena," but he can't listen to music in the usual way. He laughs whenever someone takes his picture with a camera flash, which is the only intensity of light he can perceive. He loves trying to balance himself, but his legs don't allow him to walk without support.

He is one in a million, literally.

Born deaf-blind and with a condition, osteopetrosis, that makes bones both dense and fragile, 6-year-old Orion Theodore Withrow is among an unknown number of children with a newly identified genetic disorder that researchers are just beginning to decipher. It goes by an acronym, COMMAD, that gives little away until each letter is explained, revealing an array of problems that also affect eye formation and pigmentation in eyes, skin and hair. The rare disorder severely impairs the person's ability to communicate.

Children such as Orion, who are born to genetically deaf parents, are at a higher risk, according to a recent study published in the American Journal of Human Genetics. The finding has important implications for the deaf community, said its senior author, Brian Brooks, clinical director and chief of the Pediatric, Developmental and Genetic Ophthalmology Section at the National Eye Institute.

"It is relatively common for folks in deaf community to marry each other," he said, and what's key is whether each of the couple has a specific genetic "misspelling" that causes a syndrome called Waardenburg 2A. If yes, there's the likelihood of a child inheriting the mutation from both parents. The result, researchers found, is COMMAD.

Because the disorder was only recently identified, there is much to learn about its impact over a lifetime. Brooks, who estimates that fewer than one person in a million is affected, has seen only a couple cases. Orion is one of them.

The study's finding made things clearer for Heather Withrow, Orion's mother. "It was more like an 'Oh, cool, that explains it!' kind of discovery," she said from Austin, Texas, where the family lives.

When Withrow was pregnant with Orion, she and her husband, Thomas Withrow Jr., suspected that he might be born deaf. While their daughter, 11-year-old Anastasia, has normal hearing, their other son, 12-year-old Skyler, is deaf. Then the results of initial imaging showed their third child would likely be born blind.

A subsequent MRI raised even more worries, suggesting that they were confronting trisomy 13, a chromosomal condition involving devastating physical abnormalities. Her doctor recommended the pregnancy be terminated.

"We just closed that discussion quick," Withrow recalled through an interpreter. "It is sad when people think, 'Oh well, he is going to be disabled so go ahead and end his life.' It's in God's hands. It was not my decision to make, and it wasn't my husband's decision to make."

The couple started to educate themselves about deaf-blindness - a combination that magnifies the effects of each condition. They contacted resources such as Connections Beyond Sight and Sound, a Maryland-based project that helps parents of deaf-blind children. A meeting with one of its specialists was empowering preparation. "It helped us. It let us know that we could celebrate and be happy when he was born, and not be surprised," Withrow said.

Which is what happened. "We fell in love with him at first sight," she said. As she has described on a blog she writes, Orion was long and lean, "with snowy white hair and lashes, ice-melting smile, rich laughter."

Even though he could not see, Orion's right eye would occasionally react to bright light. At just several months of age, he had special prostheses similar to "jumbo" contact lenses - called shells - inserted over his eyeballs to allow the sockets to grow proportionally with his face. And he started physical therapy to improve his motor functions. By the time he was 18 months old, he was able to keep his head straight, his mother said.

COMMAD explains those problems and others, Withrow now knows. It stands for coloboma (a condition in which normal tissue in or around the eye is missing), osteopetrosis (abnormally dense bones prone to fracture), microphthalmia (small or abnormally formed eyes), macrocephaly (abnormal enlargement of the head), albinism (lack of pigment or more specifically melanin in the skin, hair, and eyes) and deafness.

COMMAD can affect Orion in unusual ways. His body clock keeps its own schedule, his mother said, making it difficult for him to distinguish day and night: "He would think it's morning outside at 2 a.m., and he would want to play at a time when we want to go to sleep."

Such differences sometimes wear down his parents. "Despite all that, everything we do with him and everything he learns is so worth it," Withrow said.

She frequently blogs about Orion's experiences - she calls her site "A Mom's Musings" - to help educate people about COMMAD and help other parents interact with deaf-blind children. At home, she and the rest of the family use a touch-based version of American Sign Language - teaching with objects such as a baby bottle, diaper and spoon - to communicate with Orion.

The caveat of the National Eye Institute's recent study is that knowledge about how to care for and interact with children who have COMMAD is still in its infancy, Brooks said. "We are trying to understand the best ways to listen to the children," he said.

For Withow, sharing knowledge is comforting.

"Orion's life is just as important as everyone else's," she said, "and we hope he has the same opportunities as others."

health-commad

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Keywords: deaf-blindness, rare genetic disorder, genetic mutation causing deafness, COMMAD, National Eye Institute

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A mysterious medical condition gets a name - and a genetic link to deafness - Reading Eagle

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Research and DNA tests uncovers the unanswered questions of two Kokomo residents – Kokomo Tribune

Posted: at 3:49 pm

KOKOMO -- Barbara Trice hit a wall.

It was the wall of 1860, as she calls it, because she was unable to uncover historical information on her family prior to that year.

I started asking questions and I wrote some things down and I remembered some things as a teenager, Trice said of her research that has spanned years.

As a teenager living with her grandparents, she developed an interest in her ancestry. But it wasnt until five years ago that she decided to really take steps toward uncovering her past.

And it wasnt until June of 2016 the Kokomo-Howard County Public Library was able to assist Trice with her research.

Barbara had a lot of information and I used what she had to start because she knew her family and I didnt, said Amy Russell, head of the librarys Genealogy & Local History Department. And by taking the names that she had, we just took off and ran with it and did the research.

Russell was able to go back six generations in Trices familial history with research and uncovering census data. All of that information was presented Friday evening at the KHCPLs Exploring Your Story, DNA and genealogy research event.

The two-day event presented the genealogical research of two Kokomo residents, Trice and WWKI radio personality Tammy Lively.

For the last nine months, researchers at the library have been uncovering stories from the two womens past. The big reveal Friday showed the women a deeper look into their history, primarily focusing on their paternal sides.

DNA tests that they had taken months prior were also reveled to show their ethnic makeup and origins.

Each woman took two different DNA tests, while Trice took an additional test that was more advanced because of her African heritage.

Because slaves were property, and because they were property they werent recorded, Russell said about Trices need to take a more advanced DNA test.

For African Americans with slave ancestry, it is more difficult to locate documentation that traces a person back to their roots, which is why Trice hit a figurative wall in her own research.

Their names werent recorded, Russell said. With a white family the names keep going on and on, with an African American family at some point, it stops.

But Russell was able to uncover that Trices great-great-great grandfather on her mothers side, Ceasar Wilkerson, was a slave born in 1825 in Virginia. Research also showed that Wilkerson probably served in the U.S. colored troupes in the Civil War.

Like Trice, Lively had also been gathering information on her ancestry for years.

Her mother and grandmother would visit Indianapolis to do research, Lively recalls, resulting in a box full of information she was able to present to researchers.

I had a lot of information for them to start with, but I had barely any information about my fathers side of the family, Lively said.

She imagined that she could be related to royalty, and developed a fascination with the idea.

Ive always been fascinated by all things royal, Lively said. My husband teases me, and the big joke in country radio is [that] Im the queen of my double wide trailer.

But after revealing that her ancestry does in fact include the lineage of England Aristocrats, her jokes can now be backed by facts.

Ive always been fascinated with it, but I never ever dreamed that there was any connection, Lively said in awe following Fridays big reveal.

Research shows that on Livelys fathers side there are connections linking the family to King Henry VIII, who had many wives. From that lineage, a connection to Elizabeth I of England, daughter of Anne Boleyn, the second wife of King Henry VII, is made.

Discovering that she is a distant cousin to Elizabeth I of England left Lively awestruck. Not to mention, uncovering that somewhere down the line Vice President Dick Cheney is also related to Elizabeth I of England, making Lively and Cheney distantly related as well, proved to be the most surprising outcome of the night, Lively admitted.

I feel really compelled to just learn more and more about all the rest of my family, not just the fascinating things I found out about my fathers side today, but my mothers side, Lively said. Its just like an adventure now.

Both Lively and Trice also had their DNA results revealed by genealogy expert Michael Lacopo.

Lively learned she was 27 percent Irish, and also a bit Scandinavian. It was revealed that Trice was 37 percent Ghanaian, also with a sprinkle of Scandinavia.

But that breakdown should not be taken at face value, Lacopo explains, since there are still improvements to be made with ethnic DNA tests.

I always tell people, Ethnic breakdowns are dinner conversation, he said. Theyre interesting, they hold some truth, but they re not hard science.

Because ethnic DNA testing from Ancestry.com, 23andme and a rising number of genomics and biotechnology companies only test from a small database of DNA, its hard to accurately link people to a specific ethnic makeup that would be completely accurate.

The database for Ancestry.com only tests against 3000 people, Lacopo said, and thats not including the DNA of people who lived over 200 years ago.

So theres always going to be fault in those ethnic calculators, Lacopo said.

Going forward, he expects better developments in science. As more people continue to test their biological makeup, databases will increase allowing for more accurate matches, he added.

But the first step in uncovering your history isnt collecting a DNA sample or even searching online. Its talking to the eldest members of your family and collecting all of the historical data you can.

People are not renewable resources, Lacopo said. When they go, theyre gone. So ask lots of questions. Dig through their attics, find all the good stuff.

He added, Its like mining all of the information out of their heads. Heads first, computers second.

And now that Trice and Lively have both experienced how DNA and some research can uncover years of untold stories, they both hope to continue their research because the history never quite ends.

I am so elated, Trice said. I went through an up and a down through the period of time that they were looking because I know how hard it is to break the wall of 1860. But I had decided no matter how little they found or how much they found, that I would be happy with that.

For Lively, this is just the start of her adventure. She hopes others attempt to embark on the same journey.

We should know who we are, she said. It doesnt change my life in any tangible way, but its those wonderful stories that I can pass on to my own granddaughter now. I want her to know her family history.

Correction: An earlier edit identified King Henry VII as having many wives. It has been corrected to King Henry VIII.

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Research and DNA tests uncovers the unanswered questions of two Kokomo residents - Kokomo Tribune

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