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Category Archives: Transhuman News
Study: Gene Test Needed Before Using Alzheimer’s Drug ‘Off-Label’ – Journal Gazette and Times-Courier
Posted: March 9, 2017 at 2:49 am
TUESDAY, March 7, 2017 (HealthDay News) -- A drug used to treat Alzheimer's disease should not be prescribed to people with milder mental impairment without first giving them a genetic test, a new study urges.
The drug is donepezil (brand name: Aricept).
Donepezil could speed mental decline in someone with mild cognitive impairment who has a specific genetic variation, according to Sophie Sokolow, an associate professor at the UCLA School of Nursing.
She and her colleagues found that patients with the K-variant of the butyrylcholinesterase (BChE) gene who took donepezil deteriorated faster than those who took a placebo.
Donepezil is approved in the United States to treat Alzheimer's disease but not mild cognitive impairment -- the stage between normal age-related decline and dementia. However, doctors often prescribe it "off-label" for patients with mild cognitive impairment, the study authors said.
For this study, the researchers examined data from a U.S. government-funded study published in 2005 that assessed donepezil as a possible treatment for mild cognitive impairment.
The findings reinforce the importance of physicians discussing the possible benefits and risks of donepezil with their patients, the researchers said in a university news release.
The study was published recently in the Journal of Alzheimer's Disease. Funding was provide by the U.S. National Institute on Aging.
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Precision Medicine Project Mulls How to Return Genetic Test Results to 1 Million Participants – GenomeWeb
Posted: at 2:49 am
NEW YORK (GenomeWeb) Before the National Institutes of Health can begin to genetically test participants within its precision medicine initiative, it will have to figure out what results to return, how to minimize reporting false positives, and how to provide counseling to help them navigate the often uncertain and evolving evidence on genetic information.
And the project will have to figure out how to do all this on an unprecedented scale, for a million participants that the All of Us Research Program hopes to enroll over the next four years.
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Intellia R&D head says new gene-editing data shows path to human trials – Boston Business Journal
Posted: at 2:49 am
Broad Institute wins gene-editing patent case, boosting Editas shares Intellia moves into new HQ, says it plans to double headcount
John Leonard, executive vice president of R&D at Intellia
Cambridge-based Intellia Therapeutics had the biggest IPO of any local biotech in 2016, but shares of the company have lagged in recent months, and it has often been overshadowed by its gene-editing rival in Kendall Square, Editas Medicine.
On Wednesday, though, Intellia (Nasdaq: NTLA) wrested back the spotlight, announcing promising preclinical data from a study of its technology in mice that offers a pathway to potential trials involving humans.
John Leonard, executive vice president of R&D at Intellia
The company and partner Regeneron Pharmaceuticals (Nasdaq: REGN) have been developing a potential treatment for a rare hereditary disease called Transthyretin Amyloidosis, or ATTR. Intellias approach involves editing the defective genes that cause the buildup of the mutant protein responsible for the disease. The gene-editing tool, dubbed CRISPR/Cas9, is injected via lipid nanoparticles.
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Intellia R&D head says new gene-editing data shows path to human trials - Boston Business Journal
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LePage’s comments on race challenged at town hall meeting in Yarmouth – Press Herald
Posted: at 2:49 am
YARMOUTH Gov. Paul LePage faced tough questions on his history of controversial comments and on education in front of a divided crowd of several hundred people at a town hall meeting Wednesday night.
Returning to his meeting circuit after roughly two weeks in Florida and Washington, D.C., LePage predicted that the voter-approved 3 percent tax surcharge on wealthier Mainers is going to kill us, and that restaurants will struggle to fill server positions this summer because of the elimination of the tip credit.
LePage also hit his usual talking points about Maines need to lower taxes and energy costs to remain competitive during the hour-long meeting at AMVETS Post 2 in Yarmouth.
But many of the speakers in the crowd which at times did as much shouting at each other as at the governor challenged him on his priorities and his brash, politically incorrect style.
The atmosphere heated up when several speakers suggested LePage isnt doing enough publicly to condemn recent hate crimes and bomb threats against Jewish institutions.
I dont know how many middle schools and high schools I have been to, talking against bullying, LePage said. I dont know how many times I have spoken against domestic violence. Racism is a horrible crime. Im against racism.
But others pressed the governor on past comments viewed as racially charged. One speaker asked LePage why he suggested that Georgia Rep. John Lewis a civil rights icon should thank northern whites for freeing the slaves.
John Lewis made a derogatory remark to the president of the United States and I held him accountable, LePage said, referring to Lewis criticisms of then President-elect Donald Trump and Lewis plan to boycott the inauguration. LePages criticism of Lewis drew national media attention.
LePages comment Wednesday merely fired up some in the crowd.
Garrett Stewart, a black resident of Yarmouth, told LePage that his comments about Lewis and about black drug dealers coming to Maine were hurtful to his children.
Why do you say things like that on TV? Stewart said. I think its unfortunate that you say that. You are the governor of Maine. You should be above all of that.
LePage responded by telling Stewart: I apologize to you and your children, eliciting strong applause from the crowd.
Afterward, Stewart said he was tired of hearing the governor talk about black people in ways he felt were derogatory.
For my kids, sure Im glad that he apologized, Stewart said. But he added, What will he say next?
The governor also faced numerous questions on education funding.
LePage reiterated his strong opposition to the voter-approved 3 percent tax surcharge which he has proposed nullifying on Mainers earning more than $200,000 a year to provide more money for education. He also criticized the phase-out of the tip credit also approved by voters as part of a minimum wage increase that allows restaurant owners to pay tipped workers less than the minimum wage.
At one point during the event, several dozen younger audience members began shouting Respect our vote and then marched out of the hall together.
On education funding, LePage said his administration has increased K-12 funding in each budget. But some in the crowd accused the governor of shifting more of the burden of funding schools and teacher retirement onto cities and towns.
Thats because you are shifting other liabilities to local districts, one audience member told the governor.
LePage also repeated his contention that the problem facing Maine is that too much money is spent on administration with 174 superintendents for 177,000 students and not enough on classrooms.
Its the management of the school districts, its the school boards and the teachers union, LePage said. They do not want to change.
LePages proposed $6.8 billion, two-year budget would dramatically alter the states education funding formula, in part by eliminating all state funding for school administration.
Beginning in 2019, the state would provide state funds only for direct instruction and support for student learning. The administration argues that shift will result in better accountability. However, school and municipal officials predict that change would shift more costs onto municipalities, which will then be forced to increase property taxes.
During an hours-long public hearing last week, critics said LePages education budget proposal will cost schools statewide as much as $190 million and reduce state support for 65 percent of school districts.
LePage spent part of the past two weeks in Washington, D.C. fueling speculation about possible prospects in the Trump administration and said he is headed back there this week. He attended events as part of the Republican Governors Association. He also met with President Trump and posted photographs of himself and his wife with Vice President Mike Pence.
Only part of his activities in D.C. have become public, however, because LePages staff has refused to provide the media with a detailed list of events the governor attended. Asked for details on this weeks return trip, LePages spokeswoman told the Portland Press Herald the office would provide that information next week.
LePage served as a panelist at the Conservation Political Action Conference on welfare reform and then discussed his administrations efforts to reduce welfare spending on Fox News. On Wednesday, he told the Yarmouth audience that part of his trip to Washington was to push for additional work requirements for welfare recipients.
I am going to Washington and that is one of the specific issues, to have a work requirement, LePage said.
Kevin Miller can be contacted at 791-6312.
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LePage's comments on race challenged at town hall meeting in Yarmouth - Press Herald
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Serbian Singer Slams PM Over Concert ‘Censorship’ – Balkan Insight
Posted: at 2:48 am
Serbian pop singer Vlado Georgiev will consult his lawyers about suing pro-government station TV Pink for spreading false information about his concert cancellation during an interview it broadcast with Prime Minister Aleksandar Vucic, Danas newspaper reported on Wednesday.
Vucic told TV Pink on Monday that the concert scheduled for March 4in Smederevo, a town 80 kilometres south of Belgrade, wasnt forbidden but cancelled due to poor ticket sales.
Georgiev claims however that it was cancelled because he has expressed support for the former Ombudsman Sasa Jankovic, who is running against Vucic in the presidential election on April 2.
He accused TV Pink of broadcasting the most brutal lies and said he was considering suing the channel for spreading such stupidities.
He said he had not decided yet whether to sue Vucic too.
On the day of the cancelled concert, large numbers of fans of Georgiev protested by taking to the streets of Smederevo at 8.30pm, when the gig should have started, in a rally organised via Facebook.
Vucic insisted to TV Pink that only 970 people demonstrated, not 5,000 as media reports said.
Georgiev said he was informed about the cancellation of his concert via Twitter 18 days prior to the event.
To tell someone that a concert has been cancelled due to unsold tickets 18 day before the event is a brutal insult, he told Danas.
The situation I experienced made me think that Im living in Russia in Stalins times, and maybe Stalin would have killed me, but for sure he would not cancel my concert, which means that this country [Serbia] is completely subject to censorship, he added.
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Serbian Singer Slams PM Over Concert 'Censorship' - Balkan Insight
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Backers of tax cut on gold coin sales bring in Ron Paul – KTAR.com
Posted: at 2:47 am
PHOENIX Backers of a proposal exempting the sale of U.S. gold coins from state capital gains taxes brought in former congressman and presidential candidate Ron Paul on Wednesday to tout their effort at the state Senate.
The Republican testified before the Senate Finance Committee that the measure takes an important step by not taxing money.
What youre doing here, the way I understand it, is maybe we ought not to tax money, Paul said. And I think thats a good idea. Id like to not tax a lot of things, but certainly it makes no sense to tax money.
Rep. Mark Finchems House Bill 2014 is the latest effort to exempt gold coins from taxation. The Oro Valley Republican argues that taxing exchanges of legal tender like gold coins is a tax on money alone and also is essentially a tax on inflation.
Paul got pushback from Sen. Steve Farley, D-Tucson, who called the effort a way to give tax breaks to speculators and gold coin dealers.
Im trying to wrap my mind around how this isnt just another tax giveaway to coin collectors, Farley said. I get your point that you dont tax money when exchanged money for money. And I would buy that, if the $20 gold piece from 1850 was going to be traded for a $20 bill.
Instead, he noted, the price on coins is based on how much precious metal they contain and condition, not face value.
Similar efforts have earned two vetoes from Gov. Doug Ducey and one from former Gov. Jan Brewer in recent years. Ducey cited unintended consequences, while Brewer cited potential lost state revenue and a special tax break for coin dealers.
Finchems latest measure has already passed the House and was approved on a party-line 4-3 vote in the Senate Finance Committee on Wednesday. It now heads to the full Senate for consideration.
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Backers of tax cut on gold coin sales bring in Ron Paul - KTAR.com
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Jamestown Native, NASA Member Talks Mission To Mars – Jamestown Post Journal
Posted: at 2:44 am
Laurie Abadie, Jamestown native who works in NASAs Human Research Program, visited the Martz Observatory to discuss with a full crowd the research and preparations in place to send humans to Mars. P-J photo by Jimmy McCarthy
FREWSBURG A round-trip to Mars would take three years. That means youre away from your family and friends.
Youd be in a confined and isolated environment and you would survive on nutrition made of freeze-dried food.
Youd be required to exercise every day for two hours just to maintain your bone and muscle strength.
Ready for the journey?
Laurie Abadie, Jamestown native and NASA human space flight specialist, visited the Martz Observatory on Wednesday evening to discuss to a full crowd how NASA is preparing the human body for a mission to Mars.
Abadie has spent over four years in NASAs Human Research Program. She currently works in a NASA office in Cleveland, and prior to that, she spent 10 years at the Johnson Space Center in mission control where she helped cargo ships that traveled to the space station.
What the Human Research Program is tasked with is figuring out all the risks associated with sending humans to space, she said. We basically fund the research both on the ground and in flight to help make sure we keep astronauts not only safe, but healthy to have a successful mission to Mars.
Abadie said the program is examining and researching risks, and one of the biggest ones theyre delving into is space radiation. Abadie said space radiation not only causes nausea and fatigue, but it can also impact memory and the ability to think clearly. The central nervous system can be damaged and theres higher risk for cardiac disease and cancer.
To address the risk, Abadie said NASA uses a unique facility in Long Island, the Brookhaven Lab, to test space radiation.
We test different materials.We test biological samples and cells, she said. We basically send different types of radiation at it to see what would be the best material for a space craft or habitat on Mars to protect the astronauts.
Abadie said the Human Research Program is also addressing issues related to isolation, alternate gravity fields and ensuring theres enough food and medical supplies for a three-year journey.
Abadie said isolation can lead to behavioral health problems with months of confinement in a capsule. As for changes in gravity fields, she said it could cause sickness and an inability to control muscles.
Challenges are still in the way to get humans to Mars, and Abadie said theyre working to mitigate them. Abadie said NASAs looking to make the journey when Earth and Mars are at their closest point. That translates to a six-month trip leaving Earth to reach Mars.
Everything is working to a presence on Mars, she said. To get humans on Mars, we wanted to look for water. We found it and now we want to figure out wheres the best place on Mars to live, is there any life on Mars and basically how well get there.
Abadie was born and raised in Jamestown. She attended the University of Buffalo for undergraduate school where she majored in aerospace engineering.
During her junior year, she applied and was accepted to a cooperative education position at NASA Jobs and Space Center in Houston. She alternated semesters between UB and in Houston working for NASA.
Abadie continued her education and applied for the NASA Fellowship Program, which paid for her graduate school expenses while guaranteeing a job after. She attended the University of Arkansas and got a masters in space and planetary sciences. She went on to receive a second masters at the University of Colorado in space operations.
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Jamestown Native, NASA Member Talks Mission To Mars - Jamestown Post Journal
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Human guests get first up-close peek at The Edge tiger exhibit at … – The Denver Post
Posted: at 2:44 am
The Amur tiger left apond and lazily walked up a ramp to the catwalk, putting himself 12 feet above the onlooking crowd. People who were taking photos yelped and scurried away as water and perhaps something else raineddown.
The incident sparked jokes for rest of Wednesdays preview of the Denver Zoos new Edge Exhibit, which needs only a few finishing touches before it opens to the public March 17 such as a sign reminding people to look up.
Joe Amon, The Denver Post
Nikolai one of 3 Amur (Siberian) Tiger's in the new enclosure shows his teeth during a huge yawn as the Denver Zoo unveiled its new tiger exhibit, the Edge, March 8, 2017. It brings you closer to the tigers than ever before and it's nearly twice the size of the previous exhibit.
Joe Amon, The Denver Post
The Denver Zoo unveiled its new tiger exhibit, the Edge March 8, 2017. It's nearly twice the size of the previous exhibit.
Joe Amon, The Denver Post
Nikita one of 3 Amur (Siberian) Tiger's in the new enclosure with large windows as the Denver Zoo unveiled its new tiger exhibit, the Edge March 8, 2017. It brings you closer to the tigers than ever before and it's nearly twice the size of the previous exhibit.
Joe Amon, The Denver Post
Nikolai one of 3 Amur (Siberian) Tiger's in the new enclosure rolling after a short rest as the Denver Zoo unveiled its new tiger exhibit, the Edge March 8, 2017. It brings you closer to the tigers than ever before and it's nearly twice the size of the previous exhibit.
Joe Amon, The Denver Post
Metal panels designed to look like you're looking into the forest are filled with small holes. You are close enough to smell a tigers breath in the new enclosure as the Denver Zoo unveiled its new tiger exhibit, the Edge March 8, 2017. It brings you closer to the tigers than ever before and it's nearly twice the size of the previous exhibit.
Joe Amon, The Denver Post
Nikolai one of 3 Amur (Siberian) Tiger's in the new enclosure climbing down after a look from overhead as the Denver Zoo unveiled its new tiger exhibit, the Edge March 8, 2017. It brings you closer to the tigers than ever before and it's nearly twice the size of the previous exhibit.
Joe Amon, The Denver Post
Nikita one of 3 Amur (Siberian) Tiger's standing up for carnivore keeper Raejeann Eyeht in the new enclosure as the Denver Zoo unveiled its new tiger exhibit, the Edge March 8, 2017. It brings you closer to the tigers than ever before and it's nearly twice the size of the previous exhibit.
Joe Amon, The Denver Post
Nikolai one of 3 Amur (Siberian) Tiger's in the new enclosure watching as the Denver Zoo unveiled its new tiger exhibit, the Edge March 8, 2017. It brings you closer to the tigers than ever before and it's nearly twice the size of the previous exhibit.
We really wanted to give people a chance to get up close and experience the animal, Rebecca McCloskey, the zoos curator of primates and carnivores.
The new tiger exhibit has 18,200 square feet of outdoor space, including ponds, the catwalk, trees and toys, and is nearly double the size of the big cats former home. The exhibit took more than 2 years to create and roughly $2.2 million in Better Denver Bond funding from the City and County of Denver.
The exhibit has a large walk-in semicircle with windows that give the sense of being inside the enclosure with the animals. It also includes perforated metal walls so people can smell the tigers and potentially hear them chuff,the greeting noise tigers make, McCloskey said. The catwalk goes above the opening to the semicircle, allowing the cats to watch you while you watch them.
The exhibit is meant to showcase the animals athleticism and encourage their natural behaviors with logs for scratching, steps for jumping and ponds for light swimming. The catwalk lets them be up high, a position favored by the large animals. The cats behaviors indicate that they are enjoying their new environment, appearing more engaged, interested and active, McCloskey said.
My favorite part is that they have a lot of options to play and jump around and stuff, said Sophie Dawe, who is 5 years old and was wearing tiger ears and a tail. Also, they can, like, nap up there.
Sophie and her twin sister, Gwenyth, come to the zoo often and said the new tiger exhibit was their favorite part, calling the animals cool.
The zoo has three of the cool animals, brothers Nikolai and Thimbu (pronounced TIM-boo) as well as Nikita, who spent some time Wednesday morning using a tree to scratch her ear.
There are fewer than 400 Amur tigers in the wild, the cats trainer Kim Pike said. The cats used to be referred to as Siberian tigers, roaming the Russian Far East, northern China and the Korean peninsula. But as poaching and a loss of habitat threaten the species, they only remain in the Amur River area of the Russian Far East, sparking the name change. The World Wildlife Federation says they also are found in small pockets in the border areas of China and perhaps in North Korea.
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Human guests get first up-close peek at The Edge tiger exhibit at ... - The Denver Post
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Taking the robot out of the human – Huffington Post
Posted: at 2:44 am
What do Americans fear more than flying, germs, or animals? Computers replacing people in the workforce. The 2016 Chapman University Survey on American Fears found 16 percent of respondents were afraid or very afraid of losing jobs to technology. And the generation thats grown up attached to a smartphone is even more concerned. An international 2016 Infosys survey of 16-to 25-year-olds found that 40 percent thought their current jobs could be replaced by some form of automation within a decade.
So just how worried should we be about being replaced by a robot?
Not very, according to Martin Fiore, Americas Tax Talent Leader for EY, the global professional services firm. Fiore believes we should look forward to working alongside robots, particularly young people starting their careers. EY is the number two hiring firm for U.S. college graduates.
Robots can free workers from mundane tasks, allowing them to provide purpose and value at a higher level, says Fiore. EY uses Robotic Process Automation (RPA) in its tax practice, which consists of bots, or software applications that handle repetitive, high-volume automated tasks.
Our people used to have to spend hours cutting and pasting, pulling together disparate pieces of information, says Fiore. Now they can start with that information and ask What does it mean for our client? Its a huge change.
Using this type of automation allows EY workers to focus on interpreting data as they work alongside a bot, according to Fiore. He says the bots havent cost any jobs at EY.
Weve taken the robot out of the human, says Fiore, by eliminating mundane and repetitive tasks. He says this is especially important for millennials, who want to make a difference early in their careers and apply what theyve learned in college more quickly.
This sounds great for an information worker who no longer has to slog through data, but what about other industries? Momentum Machines has developed a robot that creates 400 made-to-order hamburgers in an hour without any help from humans. A 2015 Ball State University report found that almost 88 percent of job losses in manufacturing in recent years could be attributed to enhanced productivity because of automation. Can we expect more jobs to disappear as robots become cheaper and smarter?
It depends on who you ask. A 2016 Oxford University report found that 47 percent of U.S. jobs are at risk of being lost to automation over the next two decades.
But a 2016 McKinsey Global Institute report concluded that fewer than five percent of careers can be completely automated using existing technology. However, the report found about half of work activities could potentially be done by a machine. Data collection and processing and predictable physical work are the activities most likely to be automated.
Perhaps the most likely scenario is that many of us will end up working alongside robotic technology, like EYs tax practitioners, rather than being kicked to the curb by them. For example, Fiore says a robot could lay bricks while a human being directs its work.
Nearly two-thirds of Americans are already using a digital assistant or some form of robotic technology, according to Loop Intelligence. A Roomba cleaning the kitchen floor has become routine for many of us, frightening only the cat.
But even as we become more reliant on Siri and Alexa in our personal lives, accepting more automation at work wont be easy. Companies that invest in robotic technology will have to work hard to manage the people side of change. Workers worried about losing their jobs may have to learn new skills. For example, Momentum Machines, the maker of the burger bot, posted a job ad for a restaurant generalist who can troubleshoot softwarequite a different skill from whats normally expected of fast food workers.
If you look at whats ahead, youre either going to be disrupted, or get in front of the disruption, says Fiore. He says the best way to prepare workers for robotic technology is to help them understand how it will benefit themimproving the quality of their work, reducing mundane tasks, and giving them the time to provide purpose and value at a higher level.
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Taking the robot out of the human - Huffington Post
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Scientists Have Found a Way to Reverse the Signs of Aging – Futurism
Posted: at 2:44 am
Why We Age
In the absence of an actual fountain of youth, people have turned to drugs, creams, and even blood to prevent aging. But it turns out one of the best ways to combat the inevitable was right under our noses all alongexercise.
As we get older our cells lose their ability to generate energy effectively, which leads to the physical changeswe associate with aging.Researchled by Sreekumaran Nair at the Mayo Clinic reveals that high intensity interval training (HIIT) can help reverse those effects.
The study includedvolunteers from two age groups, one between 18 and 30, and the otherbetween 65 to 80. These groups were then divided into three: one received HIIT, another received weight training, and the third group was given a combination of both. All volunteers had to engage in the regimen for three months, and muscle biopsies were taken before and after for comparison.
Aging actually happens at a cellular level. As the mitochondria (the powerhouse of the cell) declines with age, it leads to many age-related conditions everything from worsening eyesight to cancer. HIIT training which involves short bursts of intense physical activity, mixed with periods of lower-intensity exercise can apparently boost the mitochondrias ability to generate energy by 69 percent among older subjects, and 49 percent in a younger group.
Perhaps the most telling sign of cellular aging is when the body begins to have difficultywith specific functions, such as the muscles ability to burn excess blood sugar which could lead to diabetes. HIIT training lead to not just a halt in thedecline, but evenreversed it. After three months of interval training, everything converged towards what we saw in young people, says Nair.
In addition to positive impacton a cellular level, the training also provideda major improvement in lung, heart, and circulation health. The amount of oxygen the younger groupcould inhale rose by 28 percent, androse by 17 percent among the older volunteers.
Among the group that was given weight training instead of HIIT, no mitochondrial or respiratory improvements were observed. Under this exercise regimen, the best benefit received was gaining muscle mass. In the group that received a combination of both, oxygen consumption rose by 21 percent among older volunteers, and showed intermediate results.In a statement announcing their research, Dr. Nair said:
Other research centered around anti-aging efforts are also making significant strides: a drug called metformin, which has long been used to treat diabetes, has just been approved for clinical trials involving its potentialage-related applications. A separate study claims to have formulated a drug that can help slow down the aging process. Having a deeper understanding of genetics has also helped scientists gainnew insights into how we can effectively slow physical aging and the onset of age-related diseases.
Given these findings, combined with numerous breakthroughs in the field, we may be closer to the fountain of youth than we think.
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Scientists Have Found a Way to Reverse the Signs of Aging - Futurism
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