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Category Archives: Transhuman News

Regeneron, Sanofi, get ready to duke it out with Pfizer over a … – Endpoints News

Posted: March 10, 2017 at 2:45 am

Andrew Blauvelt, Oregon Medical Research Center

Sometime over the next few days or weeks, the FDA will likely hand Regeneron and Sanofi an approval for Dupixent (dupilumab), their groundbreaking IL-4/IL-13 inhibitor for eczema which a number of analysts have projected will go on to grab $4 billion-plus a year in annual sales. And theyll hit the market with some stellar new 16- and 52-week data from another Phase III study as they go up against Pfizers newly approved Eucrisa (crisaborole, targeting PDE4).

We knew last year that dupilumab had hit its marks in the pivotal SOLO trials as well as CHRONOS, setting it up as possibly the top drug launch slated for 2017. Over the weekend, investigators turned out with some new goal post data for CHRONOS that will do nothing to take the shine off of its big market predictions.

In CHRONOS, researchers recruited patients whose eczema wasnt controlled by topical therapies including corticosteroids. They were divvied up into three groups: weekly 300 mg doses of dupilumab with topical corticosteroids (TCS), once every two weeks doses with TCS or TCS alone.

In the new CHRONOS data reviewed at the annual meeting of the American Academy of Dermatology in Orlando over the weekend, investigators noted that the severe itching patients are afflicted by was reduced by 55% and 58% in the two drug arms after 16 weeks, compared to 29% of patients on TCS alone. And the disease score rating for patients dropped by 4 or more points among 77% of the patients in the drug arms compared to 37% of the placebo/topical corticosteroid group.

At 52 weeks the improvement in the itching score held steady at 54% and 56% in the drug ams and 27% in the placebo group. And the 4-point-plus improvement in disease score was maintained by 65% and 76% of the patients on drug, compared to 26% on only topical corticosteroids.

Compare that to the primary goal in the crisaborole study for mild to moderate eczema:

More crisaborole- than vehicle-treated patients achieved (Investigators Static Global Assessment) score success (clear/almost clear with 2-grade improvement; AD-301: 32.8% vs 25.4%, P=.038; AD-302: 31.4% vs 18.0%, P<.001), with a greater percentage with clear/almost clear (51.7% vs 40.6%, P=.005; 48.5% vs 29.7%, P<.001).

Thats what Pfizer paid $5.2 billion for when it acquired Anacor.

Together, these drugs are expected to make a crucial difference for a big group of patients who have limited treatment options. But Regeneron and Sanofi are clearly gunning for the lions share of the market with a much broader range of late-stage data to take to payers and physicians.

They need a clear win here. Their drug sarilumab was held up by the FDA last fall over manufacturing issues. And their big PCSK9play turned into an embarrassing defensive effort to beat back a judges ruling that their drug should be pulled due to patent violations.

These new results build upon previous positive Phase III monotherapy data. In the CHRONOS study, Dupixent used with topical corticosteroids showed significantly greater clearance of skin lesions and overall disease severity compared to topical corticosteroids alone, which are commonly prescribed for moderate-to-severe atopic dermatitis, said Andrew Blauvelt, president of Oregon Medical Research Center and principal investigator of the study. This study provides positive long-term data for Dupixent, which is important given atopic dermatitis is a chronic inflammatory disease. Additionally, the presentation highlights the critical role of IL-4 and IL-13 as drivers of this atopic condition.

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5 Skin Conditions That Get Worse with Stress (and How to Chill) – Shape Magazine

Posted: at 2:45 am

Yes, you can treat your stressed-out skin topicallyand you're going to want to treat each condition as you would normally, regardless of whether it's caused by stress or not, says Dr. Gohara. Foracne, eczema, and psoriasis, a gentle, non-soap cleanser is key. And for acne, topical meds including those with benzoyl peroxide, retinol, or salicylic acidwork best. Obv, most treatments are condition-specific and best prescribed by your derm.

But that's treating the symptoms of stress rather than the root cause. Stress management is more about what's going on inside rather than outside, which is why taking care of that mental stuff is a priority. It is clear that a skinmind relationship does exist. There's so much of an overlap between dermatologic conditions and psychiatric conditions that there's an entire subspecialty within dermatology called psychodermatology, says Dr. Brown.

When it comes to treating stress that sends your skin off the wall, you can do the same stuff that chills you out otherwise. There have been studies in which acupuncture and massage therapy have been shown to reduce flare-ups and improve the state of people's eczema and their psoriasis, says Dr. Brown. But anything else that reduces stressmeditation, exercise, yoga, deep breathing, a little #selfcarecan go a long way.

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Social phobia: Indication of a genetic cause – Medical Xpress – Medical Xpress

Posted: at 2:44 am

March 9, 2017 In the Department of Genomics at the Life & Brain research center: Dr. Andreas Forstner (seated at the front), associate professor (Privatdozent) Dr. Rupert Conrad and psychologist Stefanie Rambau. Credit: Katharina Wislsperger/UKB-Ukom

People with social anxiety avoid situations in which they are exposed to judgment by others. Those affected also lead a withdrawn life and maintain contact above all on the Internet. Around one in ten people is affected by this anxiety disorder over the course of their life. Researchers at the University of Bonn have now found evidence for a gene that is believed to be linked to the illness. It encodes a serotonin transporter in the brain. Interestingly, this messenger suppresses feelings of anxiety and depressiveness. The scientists want to investigate this cause more precisely and are thus looking for more study participants. The results will be published in the journal Psychiatric Genetics.

Heart palpitations, trembling and shortness of breath: those who suffer from social phobia avoid larger groups. Verbal tests or everyday arrangements are filled with fear - after all, other people could make a negative judgement. Those affected often avoid such situations for this reason. Contact is often easier over social media or anonymously over the Internet. Social phobias are among the psychiatric disorders that are triggered simultaneously by genetic and environmental factors. "There is still a great deal to be done in terms of researching the genetic causes of this illness," says Dr. Andreas Forstner from the Institute of Human Genetics at the University of Bonn. "Until now, only a few candidate genes have been known that could be linked to this."

Individual base pairs can vary in the DNA

Together with the Clinic and Policlinic for Psychosomatic Medicine and Psychotherapy at the University Hospital Bonn, Dr. Forstner is conducting a study into the genetic causes of social phobia. The research team investigated the DNA of a total of 321 patients and compared it with 804 control individuals. The focus of the scientists lay on what are known as single nucleotide polymorphisms (SNPs). "There are variable positions in the DNA that can exist to various degrees in different people," explains Dr. Forstner.

The cause of genetic illnesses often lies in the SNPs. It is estimated that more than thirteen million such changes exist in the human DNA. The scientists investigated a total of 24 SNPs that are suspected in the widest sense of being the cause of social phobias and other mental disorders. "This is the largest association study so far into social phobia," says associate professor (Privatdozent) Johannes Schumacher from the Institute of Human Genetics at the University of Bonn.

Patients provided information about their symptoms

Over the course of the study, scientists at the Clinic and Policlinic for Psychosomatic Medicine and Psychotherapy at the University Hospital Bonn will ask the patients about their symptoms and the severity of their social phobia. Their DNA is also examined using a blood sample. Whether there is a link between the signs of the illness and the genes is being investigated by the scientists using statistical methods. The evaluation of the previously collected data indicated that an SNP in the serotonin transporter gene SLC6A4 is involved in the development of social phobia.

This gene encodes a mechanism in the brain that is involved in transporting the important messenger serotonin. This substance suppresses, among other things, feelings of fear and depressive moods. "The result substantiates indications from previous studies that serotonin plays an important role in social phobia," says associate professor (Privatdozent) Dr. Rupert Conrad from the Clinic and Policlinic for Psychosomatic Medicine and Psychotherapy. Medications that block serotonin reuptake and increase the concentration of the messenger in the tissue fluid in the brain have already long been used to treat anxiety disorders and depression.

Subjects can participate in expanded study

The scientists now want to investigate more closely what the links are between the DNA and social phobia. "In order to achieve this goal, we need many more study participants who suffer from social anxiety," says the psychologist and study coordinator Stefanie Rambau from the Clinic and Policlinic for Psychosomatic Medicine and Psychotherapy at University Hospital Bonn. Information about the study is available at http://www.SocialPhobiaResearch.de. "Those who take part will help to research social phobia. This is the basis of better diagnosis and treatment procedures in the future," says Stefanie Rambau.

Explore further: Psychotherapy normalizes the brain in social phobia

More information: Andreas J. Forstner et al, Further evidence for genetic variation at the serotonin transporter gene SLC6A4 contributing toward anxiety, Psychiatric Genetics (2017). DOI: 10.1097/YPG.0000000000000171

Anxiety in social situations is not a rare problem: Around one in ten people are affected by social anxiety disorder during their lifetime. Social anxiety disorder is diagnosed if fears and anxiety in social situations significantly ...

Previous studies have led researchers to believe that individuals with social anxiety disorder/ social phobia have too low levels of the neurotransmitter serotonin. A new study carried out at Uppsala University, however, ...

Social phobia is the most common anxiety disorder of our time. But the current treatment regimen for patients with this diagnosis has not proven very effective. Norwegian and British researchers spent 10 years studying alternative ...

Anxiety disorders affect approximately one in six adult Americans, according to the National Institute of Mental Health. The most well-known of these include panic disorder, post-traumatic stress disorder, obsessive-compulsive ...

(Medical Xpress) -- A recent study from the Centre for Emotional Health, Macquarie University, has found children with social phobia are judged as less attractive and are less liked by their peers, than children without anxiety ...

Researchers often observe inadequate parenting, a negative emotional climate and household chaos in families of children with ADHD. A research group at Goethe University Frankfurt and the universities of Bremen, Heidelberg, ...

A study led by Ravi Bansal, PhD, and Bradley S. Peterson, MD, of The Saban Research Institute of Children's Hospital Los Angeles, has found structural differences in the cerebral cortex of patients with depression and that ...

Growing up with a pet can bring social, emotional and educational benefit to children and adolescents, according to a new University of Liverpool study. Youngsters with pets tend to have greater self-esteem, less loneliness, ...

Giving people time to think about cooperating on a task can have a positive effect if they are big-picture thinkers, but if they tend to focus on their own, immediate experience, the time to think may make them less cooperative, ...

There is no added benefit to using ketamine over a standard anaesthetic during electroconvulsive therapy (ECT) according to new research from the University of Aberdeen.

People who suffer from depression should participate in yoga and deep (coherent) breathing classes at least twice weekly plus practice at home to receive a significant reduction in their symptoms.

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Study parses influence of genes, environment in metabolic disease – Science Daily

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Science Daily
Study parses influence of genes, environment in metabolic disease
Science Daily
By comparing two strains of mice -- one that becomes obese and diabetic on a high-fat diet and another resistant to a high-fat regimen -- researchers from the Perelman School of Medicine at the University of Pennsylvania identified genome-wide changes ...

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Study parses influence of genes, environment in metabolic disease - Science Daily

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Mutations in CWC27 result in spectrum of conditions – Baylor College of Medicine News (press release)

Posted: at 2:44 am

An international team of researchers has discovered that mutations in the human gene CWC27 result in a spectrum of clinical conditions that include retinal degeneration and problems with craniofacial and skeletal development. The results appear in the American Journal of Human Genetics.

CWC27 is a new disease-associated gene, said co-senior author Dr. Rui Chen, associate professor of molecular and human genetics at Baylor College of Medicine.

One of the goals of the Chen lab is to identify genes involved with human retinal disease, such as retinitis pigmentosa, a condition characterized by progressive development of night blindness and tunnel vision, sometimes from the early age of 2. Retinitis pigmentosa is the most common inherited disorder of the retina; it affects nearly 1 in 4,000 people, and more than 1 million are visually impaired around the world due to this untreatable disease.

In our search for genes linked to retinitis pigmentosa, we identified a patient with the condition more than two years ago, said co-first author Mingchu Xu, graduate student in molecular and human genetics in the Chen lab. We identified a frameshift mutation in CWC27. The patient did not have other conditions in addition to the vision problems. To study the condition, we mimicked the human mutation in a mouse model, and at 6 months of age the mice showed retinal degeneration and no other conditions, just as we had observed in the human patient.

CWC27 is one of more than 100 genes that participate in the formation and function of the spliceosome, a molecular machine that is involved in the correct expression of the proteins that carry out the functions of all the cells in the body. Until now, most disease-associated genes of the spliceosome had been involved in two non-overlapping conditions. For instance, mutations in certain proteins of the spliceosome cause syndromes that involve mainly craniofacial and skeletal conditions, while mutations in other spliceosome genes result only in retinitis pigmentosa. CWC27 seemed to belong to the second group of genes.

Surprising results

Interestingly, our collaborator Dr. Daniel Schorderet, director of the Institute for Research in Ophthalmology in Switzerland and co-senior author of the paper, was working with patients who have mutations in CWC27 and present with more severe clinical conditions than our patient, including craniofacial and skeletal problems in addition to problems with vision, Xu said.

When we looked at the clinical characteristics of all the patients, we did not anticipate that they would have mutations in the same gene. Only when we looked at the genes did we realize that the spectrum of clinical characteristic in the patients was the result of various mutations in the same gene, CWC27, Chen said.

By applying exome sequencing to multiple families and modeling the disease in two mouse models the researchers were able to appreciate the spectrum of clinical conditions that mutations in the same gene can cause.

This is the first time a mutation of a gene in the spliceosome has been described to result in an entire spectrum of clinical conditions, Xu said. To explain why our patient presented only with vision problems, we hypothesized that the mutation in our patients CWC27 was milder than those of other patients. By analyzing the results on mouse models and patient samples, we found that the mutant gene in our patient probably retains a residual function, while the genes in the patients of the other groups have a more severe loss of function.

This study also shows the power of collaboration within the genetics community when looking for new disease-associated genes, Xu said. Initially, we only identified one patient and then we collected more cases via two platforms, GeneMatcher and the European Retinal Disease Consortium. We would not have been able to present this interesting story without the contributions of researchers from nine countries. With exome sequencing accessible to more patients and researchers, these platforms will most likely speed up the process of finding the genetic causes of human diseases.

Seea complete list of authors and their affiliations and the financial support for this project.

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Trump proves himself politically inept – Fresno Bee

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Trump proves himself politically inept
Fresno Bee
In the Feb. 26 story, Sticking by President Trump, several people said they liked that he is not a politician and politically correct, liked his promised tax cuts, and were encouraged by his performance so far. Let's look at the record. Trump may not ...

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The Insanity of Self-Censorship: Climate Change, Politics, and Fear-Based Decision-Making – Climate Science Watch

Posted: at 2:43 am

Climate change has a long list of known human health consequences, not the least of which is a set of adverse impacts on mental health. As more and more people are directly affected by destructive floods, heat waves, drought, deadly storms and other extreme weather events all worsened by increasing concentrations of atmospheric carbon dioxide experts predict a steep rise in mental and social disorders: anxiety, depression, PTSD, substance abuse, increased suicide rates, and outbreaks of violence. Hardest hit will be children, the poor, the elderly, and those with existing mental health problems: collectively, this amounts to about half the US population! Worse, the consensus seems to be that the mental health profession is unprepared to handle these challenges.

Just three days after the presidential inauguration, the Centers for Disease Control (CDC) announced in a terse email that it was cancelling a three-day conference, the Climate and Health Summit, that was to take place in Atlanta from February 14-16. With the translation of science to practice as the planned theme, scientists were to present their most recent research on the physical and mental health effects of climate change, and conferees were to explore ways to improve interagency cooperation and stakeholder engagement. Though no official reason was given, it quickly became evident that the CDC had engaged in self-censorship. President Trump has alleged that global warming is a notion invented by the Chinese in order to make US manufacturing noncompetitive and, more recently, that climate change is a hoax. This strategic retreat, as one scheduled speaker characterized it, was the result of a fear-based decision to shut down the event preemptively, before the new administration had a chance to shut it down for them, absent any foreknowledge or hint that they would.

As taxpayers who underwrite interagency federal climate science to the tune of about two billion dollars a year, we should be as intolerant of self-censorship as we are of outright censorship of government information. The unfettered communication of research findings regarding climate change impacts across regions and sectors is necessary for public awareness, preparedness, and sound policymaking. As global temperatures rise, all will be better served if civil servants inoculate themselves against the chilling effect that normally accompanies the sort of tyrannical rule weve already witnessed from our new President. In all likelihood, the CDC Summit was not on the White House radar, and could have proceeded unimpeded. Instead, Al Gore and several health-related organizations swooped in, came to the rescue, and sponsored a distilled down, one-day version they called the Climate & Health Meeting. But it is not the responsibility of private citizens and organizations to pick up the slack when agencies cower.

Source: http://bit.ly/2niCFcN

Truth be told, climate change is scary; the only thing scarier, we argue, is a culture of repression in which government employees opt for the safety of silence over the invaluable service of disclosure. Fear appears to be the common denominator: deep-seated fear often underlies psychological suffering in response to dangerous conditions, and fear of retaliatory budget cuts and potential job loss motivated CDC conference organizers to cut bait in an act of anticipatory surrender. If we subscribe to the notion that knowledge is power and empowering, it only follows that the more we can know and understand how our climate system is changing and what sorts of abnormal weather patterns we can expect where we live and work, the more we can prepare ourselves across the board, including mentally and emotionally. Were calling on the CDC and all federal and state entities conducting climate research to be fearless, to stand up in defiance of those who prefer to bury their heads in the sand and insist everyone else do the same. The stakes are too high to remain in the dark.

Climate change is already taking an emotional toll, but affects people differently. Dismissive, doubtful, disengaged, cautious, concerned, and alarmed: these words have been used to describe the wide-ranging responses people have to climate change. Those who are dismissive simply refuse to accept mounting scientific evidence, and often put forth bogus arguments in an effort to disprove global warming. There are at least two underlying explanations. As can happen with a diagnosis of life-threatening cancer, some people are thrown into fear-based denial. Simple greed or zealous protection of a financial interest can also motivate some to be dismissive and deny outright the veracity of the climate threat. Some treat climate change as if it were a religion, and declare a disbelief in climate change. To this, Neil deGrasse Tyson often says that the good thing about science is that its true whether or not you believe in it. It is as ridiculous to say, I dont believe in global warming as it is to say, I dont believe in gravity both are simple laws of physics.

Those who are doubtful are reluctant to accept climate change as a reality, and tend to defend carbon-intensive lifestyles while pointing to unsettled science and denier rhetoric to defend their view. Then there are people who simply havent plugged in, are disengaged, and have failed to notice climate change as a problem that may affect them. Still others react more neutrally, are cautious, and neither fully embrace nor reject the threat of climate change, and take a wait-and-see attitude.

Yet, the science behind climate change is well-developed, so it is no surprise that a growing percentage of people are becoming deeply concerned about worsening impacts associated with climate change severe and more frequent flooding, prolonged droughts, heat waves, devastating forest fires, sea level rise, storm surges, ocean acidification, and so on. The less fortunate of us have already been the victims of one or more extreme weather events, such as massive flooding, and have lost homes, livelihoods, even loved ones. Humans are emotional creatures. People who see unchecked climate change as an existential threat, who walk around every day acutely aware of the very real prospect of an increasingly inhospitable climate system most climate scientists are in this group can easily become alarmed.

Climate change exacts a psychological toll. A landmark 2015 report in The Lancet warns that mental health disorders are one of the most dangerous indirect health effects of global warming. Multiple studies, such as those described in the US Global Change Research Programs Third National Climate Assessments Health Chapter, have shown that climate change can cause people to become chronically worried and anxious, frustrated, overwhelmed, exasperated, even clinically depressed. Hyper-vigilance, obsessive-compulsive disorders, even full-blown PTSD can result. Some mental health professionals have dubbed the uncomfortable feeling of anticipatory anxiety pre-traumatic stress disorder. Stress levels can be the greatest for those whose livelihoods are tightly wedded to the natural environment. For example, in some parts of the world, in response to a rapidly changing climate and abnormal weather conditions, farmers are committing suicide at alarming rates.

Even if we are not directly adversely affected by it in our daily lives, simple awareness of the climate threat, via the media and in normal discourse, is enough to cause anxiety. In most areas of the world, its difficult not to notice abnormal weather patterns: higher average temperatures, wild temperature swings, a lot more precipitation, or a lot less. Instinctively, many of us know something is wrong: were experiencing the small drip of climate reality.

The Climate & Health Meeting Al Gore organized was held on February 16 at the Carter Center in Atlanta, Georgia.

Over 300 people attended; Gore made opening remarks; there were two panels, about a dozen speakers, and a lunch keynote address. President Jimmy Carter made a surprise appearance and delivered a few remarks. With the possible disapproval of Congress, the CDC has to be a little cautious politically, he said, adding, The Carter Center doesnt. The Chicago Tribune noted that the move sends a powerful signal: Civil society and academic organizations will try to fill the conversation gaps about climate change left by the new administration. Georges Benjamin, executive director of the American Public Health Association (APHA), one of the meeting sponsors, commented, Were committed to making sure the nation knows about the effects of climate change on health. If anyone doesnt think this is a severe problem, they are fooling themselves. The APHA has declared 2017 the Year of Climate Change and Health. Its not clear how many CDC employees who were slated to attend the original conference were at the February 16 meeting. However, it is worth noting that two CDC staffers who did attend Dr. Patrick Breysse,director of the National Center for Environmental Health, and Dr.George Luber, an epidemiologist inthe Division of Environmental Hazards and Health Effects were requested for media interviews, but a senior CDC press officer declined to make them available. Restrictions on interactions with the press were put in place across all federal agencies soon after Trump took office; reportedly, some of these restrictions are beginning to loosen up, but we still dont know how much this administration will attempt to impede normal communications going forward.

Presenters at the meeting covered a wide variety of topics: air quality, infectious diseases, heat waves, extreme weather, vulnerable populations, state and local initiatives, adaptation measures, and the role of the health care sector. Children are particularly vulnerable, so much so that the American Academy of Pediatrics (AAP) issued a formal statement in 2015 urging pediatricians and politicians to work towards solving the climate crisis to protect the young. An AAP spokesperson noted, Their future is at stake, yet they do not vote and they have no voice in the debate. We have a moral obligation to act on their behalf. Indeed. Washington, DC-based psychiatrist Dr. Lise van Susteren, who presented on mental health at the Climate & Health Meeting (see transcript below), is convinced that the chronic failure of adults to tackle the climate change problem and implement effective solutions puts our children in harms way, and amounts to nothing less than child abuse. Its difficult to disagree; failing to provide our kids with a world thats as safe to live in as the one we were born into is something all parents should do their best to avoid.

Political interference in climate communication was a recurring problem in the Bush-Cheney administration. In October 2007, the Bush White House removed six entire pages of Congressional testimony offered by CDC Director Julie Gerberding, which linked climate change to adverse health impacts. Climate Science Watch covered the story of the eviscerated statement and published the unredacted testimony as submitted by Gerberding to the White House for customary review. It was later confirmed that Vice President Dick Cheneys office had pushed for the deletions.

Under the fossil fuel-friendly Bush Administration, many lessons were learned, and some provisions have since been put in place that protect the right to free speech of federal employees wishing to share the results of their research with the media and the public.

Given the rapidly accelerating threat of climate change and associated risks to human populations not just in America but all over the globe political interference in the communication of scientific findings crucial to informing policymakers and the public is literally a life-threatening act of betrayal against current and future generations. Keeping our Constitutional right to free speech requires that we exercise it. Please, no more self-censoring.

CSPW Senior Climate Policy Analyst Anne Polansky has 30 years of experience in public policies relating to energy and the environment, with a strong focus on climate change and renewable energy. She is a former Professional Staff Member of the House Committee on Science, Space and Technology.

~ ~ ~ ~ ~ ~ TRANSCRIPT Mental Health Consequences of Climate Change By Dr. Lise Van Susteren, Psychiatrist

Everything related to climate change either directly or indirectly all the losses, injuries, illnesses, displacements carry with them an attended emotional toll that must be acknowledged as we tally up psychological impacts of climate change. Ill start with a few of the mental health impacts for which we have precise data, and then move onto those for which we do not.

We know of the link between extreme climate and weather events to aggression. For each standard deviation of increased temperature and rainfall, we can expect a four percent increase in conflict between individuals, and a fourteen percent increase in conflict between groups. The findings are valid for all ethnicities and regions.

So, more assaults, murders and suicides, and increase in unrest all over the world should come as no surprise.

Air pollution forms more readily at higher temperatures, with particulate matter crossing of the brain via the olfactory nerve, causes neural inflammation linked to multiple mental and neurologic problems: cognitive decline in all age groups, including Alzheimers and other neurodegenerative disorders, such as Parkinsons disease and ALS. It is linked to autism and to psychiatric disorders. The American Psychological Association reports that children exposed in utero to air pollutants were more likely to have symptoms of anxiety or depression. Emergency room visits for panic attacks and threats to commit suicide are higher on days with poor air quality. Exposing workers to increasing levels of CO2 has significant impact on their cognitive functioning. The testing at indoor concentrations to which Americans are frequently exposed shows the most serious decline in our ability to think strategically, to use information, and to respond to a crisis. Not good.

But, not everything that counts can be counted. Indeed, it is the inchoate, insidious, complex, and unconscious psychological states driven by climate trauma, not lending themselves to studies and precise numbers, that are the most profoundly damaging, and drive systemic emotional conditions society will find difficult to treat and surmount.

We must think about the balance between the need for data with the need to connect emotionally, because emotional connection is at the heart of what moves people to action. Action now turns on our success, in part at least, in stirring empathy. When the place you call home is burned down, blown away, dried up, flooded when you lose your possessions, maybe your pets, your livelihood, your community see injuries, illness and death the mix of fear, anger, sorrow, and trauma can easily send a person to the breaking point. Mental health professionals are seeing a full range of psychiatric disorders: PTSD, major depression, generalized anxiety, a rise in the abuse of drugs and alcohol, domestic violence (most often against women) and a rise in child-abuse.

Some of us are lucky enough to be at a distance from the worlds climate disasters, but were not potted plants sitting here. This is empathic identification with the victims. It is painful seeing people drowned, burned, flooded, starved right? Special populations that are at risk [include] children; the elderly; the sick; the disabled; the mentally ill (of course); the poor, and those living in the bulls-eye, disaster-prone areas: along coastlines and rivers, in tornado alleys, in cities with the heat island effect. [They also include] first responders, and climate Cassandras who suffer from pre-traumatic stress disorder in the grip of images of future disasters they cant put out of their minds.

In the first published climate change delusion, a 17-year-old Australian boy had to be hospitalized for refusing to drink water, believing it would cause millions in his drought-ridden in country to die of thirst. The Melbourne childrens hospital doctor who treated him told me he has a clinic full of children with climate anxiety.

Through the result of multiple forces, climate change poses both a threat multiplier and a root cause of the mental health crisis from the explosion of refugees today searching for safety, destabilization of regions, with groups dangerous to world security rising in these feral conditions. In Europe, a sharp turn to the far right politically, the once open question about America was answered in November. In times of peril and scarcity people regress, they turn to what they perceive as strong leaders to protect them and are willing to give up their freedoms and values in exchange for perceived security.

Fears often flip to a more empowering form: anger explaining why hearing about scary climate change can evoke so much aggression. The experiences of citizens stranded at the Superdome in New Orleans in the days after Katrina are an example of how quickly our systems can be overwhelmed, and our faith in them turned upside down. Faith in a functional government is the sine qua non of a stable society.

When disasters are no longer experienced solely as acts of God or nature, but derived from the behavior of humans, it will be much tougher on us, because what happens from intentional negligence is harder to put behind us than what happens accidentally. Carried by an on-off switch, the activation of a human gene for stress in the face of trauma can be passed on to succeeding generations, compounding the toll.

A new term has been coined, solastalgia to describe the pain as seeing lands that once gave the treasured sense of home now lost or irreparably damaged. Should I have a baby? is the question increasingly being asked by young people worried about the carbon cost of bringing another person into the world. A doctoral student in anthropology at Stanford and one of his friends with whom I am in contact are discussing rational suicide in the face of climate and carbon impacts.

As we register the warning that by mid-century, 30 to 50 percent of species may be on the path to extinction, and considering the life-sustaining biodiversity, the overwhelming beauty and complexity of nature, inspiring us with awe and wonder, what our friend Eric Chivian would likely ask, is the cost, not only to human health, but the cost to our souls.

When we put people in harms way, theres a name for it, its called aggression. To our children, though they are not yet calling it this, its clearer every day that destructive inaction on climate and this is my professional opinion will be experienced as child abuse, with all the attendant mental health impacts we would expect.

Thank you.

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Twitter Fights Abuse, But Free Speech Activists Worry About Censorship – Voice of America

Posted: at 2:43 am

The social networking website Twitter has put new measures in place to try to stop users from being harassed or from seeing things that offend them.

Some free-speech activists are worried that the changes could lead to unpopular ideas being censored.

The measures were announced last week. They include hiding possibly threatening messages even if no one has complained to the company that the person who sent them is abusive.

In a statement announcing the change, the company said, Were working to identify accounts as theyre engaging in abusive behavior -- even if this behavior hasnt been reported to us."

The company said it would take action only when it strongly believes abuse has taken place. It uses software to identify abuse.

Risk to free speech?

But some free speech supporters are worried about the changes.

Suzanne Nossel is the executive director of the free speech activist group PEN America. She said Twitter is considering taking action, in her words, where there is really no problem that needs to be solved. To take action when there hasnt been a complaint raises the concern of whether there will be mistaken blocking of accounts or suspending of accounts, she said. That raises a risk.

Twitter has been pressured to deal with abusive speech in the past few months after some famous people complained about long-term, planned abuse campaigns.

Actress Leslie Jones left Twitter for a brief time last year after she received many racist messages and death threats. Several months after she met with the head of Twitter, the company announced it had developed new ways to deal with abusive messages.

Those ways included strengthening the ability of users to stop receiving messages that had certain words or expressions in them, and expanding the ability of users to report abuse.

Twitter also retrained its workers on how to deal with online abuse.

Esha Bhandari is a lawyer at the American Civil Liberties Unions Speech, Privacy, and Technology Project. She told VOA that she supports these kinds of changes, which permit users to have more control over what messages they see and from whom they receive messages.

She said the ACLU encourages companies to focus less on ways it can stop abuse and more on tools that allow users to control their experience on the platform."

Low-quality tweets and safe search function

But some tools launched by Twitter give the company a lot of power to decide what messages are seen. In February, the company began hiding what it called potentially abusive or low-quality tweets. The messages will still be able to be seen, but only if people search for them.

VOA asked Twitter many times for more information on how it decided which messages are low-quality. Twitter did not answer our questions.

Also in February, Twitter introduced a safe search function that removes messages that have potentially sensitive content from search results. VOA also asked the company how it identified this kind of message, but Twitter again did not answer our questions.

Global town square

As a private company, Twitter is not forced to permit free speech. However, spokespeople say the service permits free expression. And they say they believe in speaking truth to power.

PEN America and the ACLU support this role. Nossel and Bhandari say they consider Twitter a kind of global town square, where everyones voice has equal weight.

Bhandari said, As a practical matter, decisions made by Twitter have a huge impact on the messages that we receive, and I hope that Twitter and other companies take those responsibilities seriously."

Nossel noted that Twitter has financial reasons to be careful as it seeks to balance free expression and stopping abuse.

The power and influence of their platform depends on the free flow of ideas, so I think there are commercial reasons why they would not want to limit (free speech), Gnossel said. And I think for their users, they do have a kind of softer, implicit contract that they are going to be a platform in which you can express things freely.

Im Ashley Thompson.

VOA News Writer Joshua Fatzick reported this story from Washington. John Smith adapted the story for Learning English. Kelly Jean Kelly was the editor.

We want to hear from you. Write to us in the Comments Section, or visit our Facebook page.

________________________________________________________________

account n. an arrangement in which a person uses the Internet or e-mail services of a particular company

complain v. to say or write that you are unhappy, sick, uncomfortable, etc., or that you do not like something

engage in phrasal verb to do (something)

encourage v. to make (something) more appealing or more likely to happen

allow v. to make it possible for someone or something to have or do something

focus v. to direct your attention or effort at something specific

racism n. the belief that some races of people are better than others

potentially adv. capable of becoming real

function n. the special purpose or activity for which a thing exists or is used

platform n. something that allows someone to tell a large number of people about an idea, product, etc.

practical adj. likely to succeed and reasonable to do or use

impact n. logical and reasonable in a particular situation

implicit adj. understood though not clearly or directly stated

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Taiwan Is Desperate for Fee-Paying, Mainland Chinese Students. That Could Be Bad for Academic Freedom – TIME

Posted: at 2:43 am

Taiwan's universities are reeling from accusations that they are indulging in widespread academic censorship to secure lucrative fee-paying exchange students from the Chinese mainland.

This week the Ministry of Education launched an emergency probe of pledges allegedly signed by universities with their Chinese counterparts to uphold Chinas official view on Taiwans status and avoid teaching sensitive content like Taiwanese independence.

The controversy has struck at a particularly sensitive time, with the island nation smarting from a strong rebuke last weekend by Chinese Premier Li Keqiang, who warned that China would not tolerate any activity attempting to separate Taiwan from the motherland.

Taiwan, a democracy of 23 million, has its own parliament, military and foreign policy, but Beijing views it as a renegade province that will eventually be reunited with the mainland by military force if necessary.

The Education Ministry refused to confirm press reports that at least 80 out of 157 universities may have compromised their academic independence to attract Chinese students, until it completes its full investigation next week.

But Yang Min-ling, head of the ministrys International Department, warned that any institution found guilty of violating laws governing cross-strait relations between Taiwan and China could face fines of up to $16,000.

Fearful that Beijing is trying to erode their jealously guarded academic liberties, Taiwanese professors and students are in revolt.

A new campaign against political restrictions on academic freedom by Professor Fan Yun, who teaches sociology at National Taiwan University, has been supported by professors and students from over 20 institutions.

Universities are supposed to protect the democratic values of a society, says Fan.

I visit Hong Kong universities and whats happening there is quite depressing. They already lost the freedom to talk about what they want to. So I hope that we are overworried, but we dont want to wait until its too late, she argues.

We still want to facilitate academic exchange with China, but we have to have our bottom line.

With Taiwans low birth rate fueling fears of a future shortfall in students, however, that line appears to be flexible for many universities competing for funding. Taiwan, which has a glut of universities, gratefully receives over 30,000 Chinese exchange students every year.

The latest controversy began at Shih Hsin University in the capital, Taipei, after it revealed that in letters to some mainland Chinese students it vowed to avoid sensitive subjects.

A spokesman, Yeh I-jan, argued that the letters were nonbinding and only necessary for about 5% of the institutions annual 1,500 Chinese students.

Shih Hsin and other universities claim such documents are a formality to placate the Chinese authorities, denying that teaching standards are compromised. But Yeh did recall several instances where Chinese students had complained about the content of lessons and stopped attending.

Young activists in both Hong Kong and Taiwan have irked Beijing in recent years by pushing for greater autonomy or even independence. In 2014, hundreds of students formed the Sunflower Movement and occupied Taiwans parliament to protest Chinas political influence.

Lin Fei-fan, one of Sunflowers leaders, is alarmed that the letters issued by universities have both violated Taiwans academic freedom and burdened visiting Chinese students with self-censorship. But he also sees an opportunity.

This incident actually gives us a rare chance to rethink how a democratic Taiwan can engage with an authoritarian and inimical neighbor country through education exchange, he says.

Concerns about China using its overseas students for political leverage have occurred elsewhere.

In San Diego, Chinese students protested against a decision by the University of California to invite Tibetan spiritual leader, the Dalai Lama. Meanwhile, the Chinese embassy in the U.K. is said to have warned students at Durham University against engaging with human-rights activist, Anastasia Lin.

Its part of how they want to promote their cultural and social agenda in other societies, particularly in Taiwan, said Hsu Yung-ming, a legislator with the government-aligned New Power Party.

We worry that our universities maybe have some under-the-table compromise with China.

But Jason Hsu, a legislator from the opposition party, the Kuomintang, warned the government against a kneejerk reaction.

While opposing pledges to Chinese universities, Hsu believes that the Ministry of Education probe, with the threat of financial penalties, is also overreaching.

He asks: Do we want zero students from China in Taiwan, or do we want to promote more exchange and understanding towards each other? I think I would vote for the latter.

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Ron Paul: Arizona Challenges the Fed’s Money Monopoly – Noozhawk

Posted: at 2:42 am

History shows that, if individuals have the freedom to choose what to use as money, they will likely opt for gold or silver.

Of course, modern politicians and their Keynesian enablers despise the gold or silver standard. This is because linking a currency to a precious metal limits the ability of central banks to finance the growth of the welfare-warfare state via the inflation tax. This forces politicians to finance big government much more with direct means of taxation.

Despite the hostility toward gold from modern politicians, gold played a role in U.S. monetary policy for 60 years after the creation of the Federal Reserve. Then, in 1971, as concerns over the U.S. governments increasing deficits led many foreign governments to convert their holdings of U.S. dollars to gold, President Richard Nixon closed the gold window, creating Americas first purely fiat currency.

Americas 46-year experiment in fiat currency has gone exactly as followers of the Austrian school predicted: a continuing decline in the dollars purchasing power accompanied by a decline in the standard of living of middle- and working-class Americans, a series of Fed-created booms followed by increasingly severe busts, and an explosive growth in government spending.

Federal Reserve policies are also behind much of the increase in income inequality.

Since the 2008 Fed-created economic meltdown, more Americans have become aware of the Federal Reserves responsibility for Americas economic problems.

This growing anti-Fed sentiment is one of the key factors behind the liberty movements growth, and represents the most serious challenge to the Feds legitimacy in its history. This movement has made Audit the Fed into a major national issue that is now closer than ever to being signed into law.

Audit the Fed is not the only focus of the growing anti-Fed movement. For example, the Arizona Senate Finance and Rules committees is considering legislation officially defining gold, silver and other precious metals as legal tender.

The bill, HB 2014, also exempts transactions in precious metals from state capital gains taxes, thus ensuring that people are not punished by the taxman for rejecting Federal Reserve notes in favor of gold or silver.

Since inflation increases the value of precious metals, these taxes give the government one more way to profit from the Federal Reserves currency debasement.

HB 2014 is a very important and timely piece of legislation. The Federal Reserves failure to reignite the economy with record-low interest rates since the last crash is a sign that we may soon see the dollars collapse. It is therefore imperative that the law protect peoples right to use alternatives to what may soon be virtually worthless Federal Reserve notes.

Passage of HB 2014 would also send a message to Congress and President Donald Trumps administration that the anti-Fed movement is growing in influence.

Thus, passage of this bill will not just strengthen movements in other states to pass similar legislation; it will also help build support for the Audit the Fed bill and legislation repealing federal legal tender laws.

I was in Phoenix this week to help rally support for HB 2014, speaking on behalf of the bill before the Arizona Senate Finance Committee and at a rally at the state capitol. I hope every supporter of sound money in Arizona joins me to show their support for ending the Feds money monopoly.

Ron Paul is a retired congressman, former presidential candidate, and founder and chairman of the Ron Paul Institute for Peace & Prosperity. Click here to contact him, follow him on Twitter: @RonPaul, or click here to read previous columns. The opinions expressed are his own.

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