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Category Archives: Transhuman News

The future of space colonization terraforming or space habitats? – Phys.Org

Posted: March 11, 2017 at 7:48 am

March 10, 2017 by Matt Williams, Universe Today Artist's concept of a terraformed Mars (left) and an O'Neill Cylinder. Credit: Ittiz/Wikimedia Commons (left)/Rick Guidice/NASA Ames Research Center (right)

The idea of terraforming Mars aka "Earth's Twin" is a fascinating idea. Between melting the polar ice caps, slowly creating an atmosphere, and then engineering the environment to have foliage, rivers, and standing bodies of water, there's enough there to inspire just about anyone! But just how long would such an endeavor take, what would it cost us, and is it really an effective use of our time and energy?

Such were the questions dealt with by two papers presented at NASA's "Planetary Science Vision 2050 Workshop" last week (Mon. Feb. 27th Wed. Mar. 1st). The first, titled "The Terraforming Timeline", presents an abstract plan for turning the Red Planet into something green and habitable. The second, titled "Mars Terraforming the Wrong Way", rejects the idea of terraforming altogether and presents an alternative.

The former paper was produced by Aaron Berliner from the University of California, Berkeley, and Chris McKay from the Space Sciences Division at NASA Ames Research Center. In their paper, the two researchers present a timeline for the terraforming of Mars that includes a Warming Phase and an Oxygenation Phase, as well as all the necessary steps that would precede and follow.

As they state in their paper's Introduction:

"Terraforming Mars can be divided into two phases. The first phase is warming the planet from the present average surface temperature of -60 C to a value close to Earth's average temperature to +15 C, and recreating a thick CO atmosphere. This warming phase is relatively easy and quick, and could take ~100 years. The second phase is producing levels of O in the atmosphere that would allow humans and other large mammals to breath normally. This oxygenation phase is relatively difficult and would take 100,000 years or more, unless one postulates a technological breakthrough."

Before these can begin, Berliner and McKay acknowledge that certain "pre-terraforming" steps need to be taken. These include investigating Mars' environment to determine the levels of water on the surface, the level of carbon dioxide in the atmosphere and in ice form in the polar regions, and the amount of nitrates in Martian soil. As they explain, all of these are key to the practicality of making a biosphere on Mars.

So far, the available evidence points towards all three elements existing in abundance on Mars. While most of Mars water is currently in the form of ice in the polar regions and polar caps, there is enough there to support a water cycle complete with clouds, rain, rivers and lakes. Meanwhile, some estimates claim that there is enough CO in ice form in the polar regions to create an atmosphere equal to the sea level pressure on Earth.

Nitrogen is a also fundamental requirement for life and necessary constituent of a breathable atmosphere, and recent data by the Curiosity Rover indicate that nitrates account for ~0.03% by mass of the soil on Mars, which is encouraging for terraforming. On top of that, scientists will need to tackle certain ethical questions related to how terraforming could impact Mars.

For instance, if there is currently any life on Mars (or life that could be revived), this would present an undeniable ethical dilemma for human colonists especially if this life is related to life on Earth. As they explain:

"If Martian life is related to Earth life possibly due to meteorite exchange then the situation is familiar, and issues of what other types of Earth life to introduce and when must be addressed. However, if Martian life in unrelated to Earth life and clearly represents a second genesis of life, then significant technical and ethical issues are raised."

To break Phase One "The Warming Phase" down succinctly, the authors address an issue familiar to us today. Essentially, we are altering our own climate here on Earth by introducing CO and "super greenhouse gases" to the atmosphere, which is increasing Earth's average temperature at a rate of many degrees centigrade per century. And whereas this has been unintentional on Earth, on Mars it could be re-purposed to deliberately warm the environment.

"The timescale for warming Mars after a focused effort of super greenhouse gas production is short, only 100 years or so," they claim. "If all the solar incident on Mars were to be captured with 100% efficiency, then Mars would warm to Earth-like temperatures in about 10 years. However, the efficiency of the greenhouse effect is plausibly about 10%, thus the time it would take to warm Mars would be ~100 years."

Once this thick atmosphere has been created, the next step involves converting it into something breathable for humans where O levels would be the equivalent of about 13% of sea level air pressure here on Earth and CO levels would be less than 1%. This phase, known as the "Oxygenation Phase", would take considerably longer. Once again, they turn towards a terrestrial example to show how such a process could work.

Here on Earth, they claim, the high levels of oxygen gas (O) and low levels of CO are due to photosynthesis. These reactions rely on the sun's energy to convert water and carbon dioxide into biomass which is represented by the equation HO + CO = CHO + O. As they illustrate, this process would take between 100,000 and 170,000 years:

"If all the sunlight incident on Mars was harnessed with 100% efficiency to perform this chemical transformation it would take only 17 years to produce high levels of O. However, the likely efficiency of any process that can transform HO and CO into biomass and O is much less than 100%. The only example we have of a process that can globally alter the CO and O of an entire plant is global biology. On Earth the efficiency of the global biosphere in using sunlight to produced biomass and O2 is 0.01%. Thus the timescale for producing an O rich atmosphere on Mars is 10,000 x 17 years, or ~ 170,000 years."

However, they make allowances for synthetic biology and other biotechnologies, which they claim could increase the efficiency and reduce the timescale to a solid 100,000 years. In addition, if human beings could utilize natural photosynthesis (which has a comparatively high efficiency of 5%) over the entire planet i.e. planting foliage all over Mars then the timescale could be reduced to even a few centuries.

Finally, they outline the steps that need to be taken to get the ball rolling. These steps include adapting current and future robotic missions to assess Martian resources, mathematical and computer models that could examine the processes involved, an initiative to create synthetic organisms for Mars, a means to test terraforming techniques in a limited environment, and a planetary agreement that would establish restrictions and protections.

Quoting Kim Stanley Robinson, author of the Red Mars Trilogy, (the seminal work of science fiction about terraforming Mars) they issue a call to action. Addressing how long the process of terraforming Mars will take, they assert that we "might as well start now".

To this, Valeriy Yakovlev an astrophysicist and hydrogeologist from Laboratory of Water Quality in Kharkov, Ukraine offers a dissenting view. In his paper, "Mars Terraforming the Wrong Way", he makes the case for the creation of space biospheres in Low Earth Orbit that would rely on artificial gravity (like an O'Neill Cylinder) to allow humans to grow accustomed to life in space.

Looking to one of the biggest challenges of space colonization, Yakovlev points to how life on bodies like the Moon or Mars could be dangerous for human settlers. In addition to being vulnerable to solar and cosmic radiation, colonists would have to deal with substantially lower gravity. In the case of the Moon, this would be roughly 0.165 times that which humans experience here on Earth (aka. 1 g), whereas on Mars it would be roughly 0.376 times.

The long-term effects of this are not known, but it is clear it would include muscle degeneration and bone loss. Looking farther, it is entirely unclear what the effects would be for those children who were born in either environment. Addressing the ways in which these could be mitigated (which include medicine and centrifuges), Yakovlev points out how they would most likely be ineffective:

"The hope for the medicine development will not cancel the physical degradation of the muscles, bones and the whole organism. The rehabilitation in centrifuges is less expedient solution compared with the ship-biosphere where it is possible to provide a substantially constant imitation of the normal gravity and the protection complex from any harmful influences of the space environment. If the path of space exploration is to create a colony on Mars and furthermore the subsequent attempts to terraform the planet, it will lead to the unjustified loss of time and money and increase the known risks of human civilization."

In addition, he points to the challenges of creating the ideal environment for individuals living in space. Beyond simply creating better vehicles and developing the means to procure the necessary resources, there is also the need to create the ideal space environment for families. Essentially, this requires the development of housing that is optimal in terms of size, stability, and comfort.

In light of this, Yakolev presents what he considers to be the most likely prospects for humanity's exit to space between now and 2030. This will include the creation of the first space biospheres with artificial gravity, which will lead to key developments in terms of materials technology, life support-systems, and the robotic systems and infrastructure needed to install and service habitats in Low Earth Orbit (LEO).

These habitats could be serviced thanks to the creation of robotic spacecraft that could harvest resources from nearby bodies such as the Moon and Near-Earth Objects (NEOs). This concept would not only remove the need for planetary protections i.e. worries about contaminating Mars' biosphere (assuming the presence of bacterial life), it would also allow human beings to become accustomed to space more gradually.

As Yakovlev told Universe Today via email, the advantages to space habitats can be broken down into four points:

"1. This is a universal way of mastering the infinite spaces of the Cosmos, both in the Solar System and outside it. We do not need surfaces for installing houses, but resources that robots will deliver from planets and satellites. 2. The possibility of creating a habitat as close as possible to the earth's cradle allows one to escape from the inevitable physical degradation under a different gravity. It is easier to create a protective magnetic field.

"3. The transfer between worlds and sources of resources will not be a dangerous expedition, but a normal life. Is it good for sailors without their families? 4. The probability of death or degradation of mankind as a result of the global catastrophe is significantly reduced, as the colonization of the planets includes reconnaissance, delivery of goods, shuttle transport of people and this is much longer than the construction of the biosphere in the Moon's orbit. Dr. Stephen William Hawking is right, a person does not have much time."

And with space habitats in place, some very crucial research could begin, including medical and biologic research which would involve the first children born in space. It would also facilitate the development of reliable space shuttles and resource extraction technologies, which will come in handy for the settlement of other bodies like the Moon, Mars, and even exoplanets.

Ultimately, Yakolev thinks that space biospheres could also be accomplished within a reasonable timeframe i.e. between 2030 and 2050 which is simply not possible with terraforming. Citing the growing presence and power of the commercial space sector, Yakolev also believed a lot of the infrastructure that is necessary is already in place (or under development).

"After we overcome the inertia of thinking +20 years, the experimental biosphere (like the settlement in Antarctica with watches), in 50 years the first generation of children born in the Cosmos will grow and the Earth will decrease, because it will enter the legends as a whole As a result, terraforming will be canceled. And the subsequent conference will open the way for real exploration of the Cosmos. I'm proud to be on the same planet as Elon Reeve Musk. His missiles will be useful to lift designs for the first biosphere from the lunar factories. This is a close and direct way to conquer the Cosmos."

With NASA scientists and entrepreneurs like Elon Musk and Bas Landorp looking to colonize Mars in the near future, and other commercial aerospace companies developing LEO, the size and shape of humanity's future in space is difficult to predict. Perhaps we will jointly decide on a path that takes us to the Moon, Mars, and beyond. Perhaps we will see our best efforts directed into near-Earth space.

Or perhaps we will see ourselves going off in multiple directions at once. Whereas some groups will advocate creating space habitats in LEO (and later, elsewhere in the Solar System) that rely on artificial gravity and robotic spaceships mining asteroids for materials, others will focus on establishing outposts on planetary bodies, with the goal of turning them into "new Earths".

Between them, we can expect that humans will begin developing a degree of "space expertise" in this century, which will certainly come in handy when we start pushing the boundaries of exploration and colonization even further.

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We're more likely to resort on space habitats. Not that Mars isn't tempting, but it would ask too much time, ressources and close to no disasters for it to be another place to live in. And, of course, there could be more on it that we need to discover before doing anything we would regret. What's more, we'll need to relocate our growing population. Being able to control it by creating new homes with little risks of destroying anything in the process isn't bad at all. But again, we'll still need time and ressources for this. And in the long, long term, we'll need other worlds anyway. Space habitats are cool and all, but planets (habitable ones, that is) are less likely to explode due to some flying rocks not paying attention to red lights....that and other things.

The Glitter Band - ring of human habitats orbiting a planet. The planet is where you go for a vacation, not to live.

100,000? Forget it. What the authors are saying is that, with current or foreseeable technology, this is an impossible project. If within the next 300 years we have not learned how to terraform Mars in, at worst, a few decades, we will never do it.

The initial exploration & colonization 'of space' probably will be things like asteroid mining and solar powersats for Earth. That will naturally entail space stations & hollowed-out asteroid colonies, and will be driven by business. However, terraforming will happen too. And people who migrate in large #s to the newly opened planets can simply modify themselves via genetic engineering to adapt to the different gravity, etc. After all, that'll be old tech by the time they're ready.

Underground living offers protection from radiation and impactors, ready access to resources rather than mining distant bodies, and airtight enclosures. Water reservoirs in liquid form, skylights for natural light, no need for artificial gravity,

The advantages are clear.

Lot of literature about space living. One of those O'Niell cylinders would make a really good system ship with proper propulsion, like Dr Lerner's Focus Fusion system which makes a fusion thruster and an electromagnetodynamic generator for power to the ship. Lots of resources among bodies in this system. Free of planetary dominance and most politics, a free roaming (NO low earth orbit limitations, atmospheric frag, orbit degradation,etc) and entirely self sufficient ship with one 'gee' living and working conditions would be able to live near if not 'inside' the asteroid belt where its supplies would last....forever. It could export the mined materials to earth for it's international sponsors, and also could travel to the vicinity of the Moon for its shuttles to mine lunar regolith for new colony ship (may as well say colony ship....it is a colony and it lives on a really big ship) construction. Fuel..our system is running over with boron and hydrogen and water everywhere.

I've read terraforming Mars suggestions for twenty years, and they all start with the same nonsense claim that humans are doing a great job warming Earth. They ignore that it's taken 9 billion humans 200 years to warm Earth by 0.9 C. Where do these kooks get this idea that Earth is warming at "a rate of many degrees centigrade per century," or that we could see such results on Mars? Even if we could do it, though, it would be a waste of resources to do so. We see what equilibrium Mars is like. Moving from that requires continuous effort and materials, much of which fizzles into space, lost.

"an underground nuclear detonation created large quantities of heat as well as radioisotopes, but most would quickly become trapped in the molten rock and become unusable as the rock resolidifed." https://en.wikipe...ct_Gnome

-And what makes you think that explosives couldnt be designed to minimize residual radiation or that it couldnt be mitigated?

I think that the plowshare tests were conducted when the need for self-sustaining underground refuges in light of NBC threats became obvious during the cold war.

While Mars may be a far more hospitable place to develop technologies for terraforming, if we are talking about investing tens of thousands of years, and the goal is to create earth's twin, then Venus is the obvious candidate. Not only would the gravity be very similar, but the chances of creating a stable earth like environment would be much better.

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The future of space colonization terraforming or space habitats? - Phys.Org

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ASU students compete for a journey to the moon – Arizona State University

Posted: at 7:48 am

March 10, 2017

Unlocking humanitys future as an interplanetary species is no simple feat.

But students at Arizona State University and the Central University of Tamil Nadu in India are up for the challenge. The international collaboration is vying for a chance to induce photosynthesis on the moon.

Photosynthesis is the basis of all life, said Jonathon Barkl, a physics and economics major in the College of Liberal Arts and Sciences. If it can happen on another planet, were one step closer to proving humanity can eventually do the same.

The quest to help build sustainable life on the moon started with TeamIndus, the only Indian team competing for the Google Lunar XPRIZE. The $30 million international competition inspires innovators to develop low-cost methods of robotic space exploration and be the first privately funded team to land spacecraft on the moon, travel 500 meters and transmit high-definition video and images back to Earth.

TeamIndus has officially secured a launch contract with Indias Space Research Organization to send a lander to the moon in December 2017. As part of their mission to catalyze humankind as a multi-planetary species, TeamIndus created the Lab2Moon challenge to fly one youth experiment aboard their spacecraft to the moon.

We have this amazing opportunity to send a payload to the lunar surface and conduct science that could impact the future of human exploration, said Barkl, a member of the ASU/CUTN Lab2Moon team. It blows my mind every time I think about it.

During phase one of the challenge, TeamIndus received 3,000 entries from across the globe explaining a range of experiments to catalyze the evolution of humankind from growing plants on the moon to investigating the lunar subsurface.

Twenty-five teams were shortlisted in the competition to build prototypes of their concept, including the ASU/CUTN Lab2Moon team who are eager to determine if photosynthesis can take place on the moon with its very hostile conditions.

The premise of our mission is taking cyanobacteria a really robust and primitive life form and placing it on the lunar surface to see how it affects the photosynthesis process, Barkl said. If cyanobacteria can photosynthesize and thrive on this surface, we can use it as a means of potentially producing energy, food or even possibly terraforming another planet.

The ASU/CUTN Lab2Moon team has been developing a strategy for putting their mission on the moon, from outlining power requirements to maintaining a safe environment for the bacteria. As they start to develop a full-on prototype of their project, they have to meet TeamIndus three criteria: be the size of a regular soda can, weigh less than 250 grams and connect to the spacecrafts on-board computer.

Its a unique challenge to coordinate between the two universities, Barkl said. Were halfway around the world and our colleagues are 12.5 hours ahead. Well message them while theyre trying to sleep or theyll message us when were in class. The time coordination is hard, but its going well.

During the development stage, the team has broken down responsibilities for the members at each university. Santosh and Sukanya Roychowdhury from CUTN will be developing the space capsule and testing it for space-grade readiness, structural integrity and its ability to withstand pressure and temperature. Barkl, Aidan McGirr and Autumn Conner from ASU will determine how to configure the electronics with the on-board computer, prepare the cyanobacteria and test the capsules sensors.

Our mission is very heavy in science and data because were going to have about nine sensors whereas several other teams have only two or three, Barkl said. We have two main groups of sensors: one for maintaining a relatively friendly environment for the cyanobacteria and one for measuring the output of photosynthesis as the function of radiation on the lunar surface.

Members of the Arizona State University and the Central University of Tamil Nadu Lab2Moon team (from left) Autumn Conner, Jonathon Barkl and Aidan McGirr along with Rakshith Dekshidar (right), a graduate student in electrical engineering, who has been helping the team configure the space capsule's sensors and electronics systems.

After their second design review with TeamIndus, the ASU/CUTN Lab2Moon team was invited to the final stage of the competition. The team will showcase their prototype to an international team of judges in Bangalore, India, on March 13, where theyll find out who gets to fly with TeamIndus to the moon this year.

We see professors from the School of Earth and Space Exploration all the time getting research grants from NASA and winning different missions. Its inspiring to think, Wow, I can go to space too, Barkl said. ASU has never had a student mission of this caliber. We want to prove that not only are the faculty doing amazing science, but so are the students.

Although Barkl is a student in the Department of Physics, he considers himself an honoree member of the School of Earth and Space Exploration. The research being conducted in the school was the reason he decided to attend the university and what inspired him to pursue this competition.

The ASU community has really been a huge support for us, Barkl said. Its a humbling experience to work with so many inspiring researchers who are so supportive and answer all our questions. If we had three years to research these questions, we could probably figure them out on our own. But with such a short turnaround time, they have really helped us make this project possible.

The teams mentors include Lindy Elkins-Tanton, planetary scientist and director of the School of Earth and Space Exploration; Philip Christensen, geologist and geophysicist; Scott Parazynski, retired NASA astronaut and current professor of practice; Ferran Garcia-Pichel, dean of natural sciences in the College of Liberal Arts and Sciences; Mark Jacobs, dean of Barrett, The Honors College and professor in the School of Life Sciences; Mark Naufel, director of strategic projects at the university; and Scott Smas, program manager of ASUs Space Technology and Science Initiative.

ASU has provided us with funding, supplies, facilities and mentorship, Barkl said. Having access to all these resources has pretty much changed the game for us.

Barkl and McGirr, an astrophysics major, want to use the Lab2Moon project to kick off a miniature space agency and private, student-run organization at ASU where students can take what they are learning in the classroom and apply it in a meaningful way to advance space technologies.

What I look forward to most is being able to say Ive contributed to the goal of human colonization on other planets, Barkl said. And we want to prove that students can do meaningful work in the space sector too.

To learn more about the ASU/CUTN Lab2Moon mission, visit the teams website and Facebook page.

Top photo: The moon photographed by the Lunar Reconnaissance Orbiter Camera team at ASU. Photo by NASA/GSFC/Arizona State University

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GOP-sponsored bill may help companies obtain your genetic information – Fox News

Posted: at 7:48 am

House Democrats and a number of privacy advocacy groups came out against a House GOP-sponsored bill that would reportedly make it easier for employers to gain access to genetic information about their employees and their families.

The New York Times reported Friday that the bill-- called the Preserving Employee Wellness Programs Act-- may also significantly increase the costs if someone chooses not to participate in a company wellness program that requires the genetic information.

Fortune magazine summed up the bill: it would essentially allow companies with workplace wellness programs to demand your genetic information (or force you to pay a big penalty.)

The bill was introduced by Rep. Virginia Foxx, R-N.C., the chairwoman of the House Committee on Education and the Workforce. The bill reportedly passed its first test in a committee vote that went straight down party line. The bill is still under review by other House committees.

A spokeswoman for the House committee told The Times that "the legislation will reaffirm existing law and provide regulatory clarity so that employers can have the certainty they need to help lower health care costs for their employees.

There is debate on the effectiveness of workplace wellness programs in general.

"We urge the Committee not to move forward with consideration of this bill," Nancy J. Cox, PhD, the president of the American Society of Human Genetics, said in a statement. As longtime advocates of genetic privacy, we instead encourage the Committee to pursue ways to foster workplace wellness and employee health without infringing upon the civil rights afforded by ADA and GINA."

She said if enacted, the bill would "fundamentally undermine" the Genetic information Nondiscrimination Act and the Americans with Disabilities Act.

Edmund DeMarche is a news editor for FoxNews.com. Follow him on Twitter @EDeMarche.

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GOP-sponsored bill may help companies obtain your genetic information - Fox News

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For the first time ever, scientists have edited the genetic makeup of viable human embryos – Quartz

Posted: at 7:48 am


Popular Mechanics
For the first time ever, scientists have edited the genetic makeup of viable human embryos
Quartz
Our genetically edited future is nigh. Chinese researchers, who have been at the forefront of experimenting with human embryos using a technology called CRISPR, are improving on their results year after year. For the past three years, these researchers ...
Chinese Scientists Genetically Modify Human EmbryosPopular Mechanics

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Mutations in CWC27 result in a spectrum of developmental conditions – Medical Xpress

Posted: at 7:48 am

March 10, 2017

An international team of researchers has discovered that mutations in the human gene CWC27 result in a spectrum of clinical conditions that include retinal degeneration and problems with craniofacial and skeletal development. The results appear in the American Journal of Human Genetics.

"CWC27 is a new disease-associated gene," said co-senior author Dr. Rui Chen, associate professor of molecular and human genetics at Baylor College of Medicine.

One of the goals of the Chen lab is to identify genes involved with human retinal disease, such as retinitis pigmentosa, a condition characterized by progressive development of night blindness and tunnel vision, sometimes from the early age of 2. Retinitis pigmentosa is the most common inherited disorder of the retina; it affects nearly 1 in 4,000 people, and more than 1 million are visually impaired around the world due to this untreatable disease.

"In our search for genes linked to retinitis pigmentosa, we identified a patient with the condition more than two years ago," said co-first author Mingchu Xu, graduate student in molecular and human genetics in the Chen lab. "We identified a frameshift mutation in CWC27. The patient did not have other conditions in addition to the vision problems. To study the condition, we mimicked the human mutation in a mouse model, and at 6 months of age the mice showed retinal degeneration and no other conditions, just as we had observed in the human patient."

CWC27 is one of more than 100 genes that participate in the formation and function of the spliceosome, a molecular machine that is involved in the correct expression of the proteins that carry out the functions of all the cells in the body. Until now, most disease-associated genes of the spliceosome had been involved in two non-overlapping conditions. For instance, mutations in certain proteins of the spliceosome cause syndromes that involve mainly craniofacial and skeletal conditions, while mutations in other spliceosome genes result only in retinitis pigmentosa. CWC27 seemed to belong to the second group of genes.

Surprising results

"Interestingly, our collaborator Dr. Daniel Schorderet, director of the Institute for Research in Ophthalmology in Switzerland and co-senior author of the paper, was working with patients who have mutations in CWC27 and present with more severe clinical conditions than our patient, including craniofacial and skeletal problems in addition to problems with vision," Xu said.

"When we looked at the clinical characteristics of all the patients, we did not anticipate that they would have mutations in the same gene. Only when we looked at the genes did we realize that the spectrum of clinical characteristic in the patients was the result of various mutations in the same gene, CWC27," Chen said.

By applying exome sequencing to multiple families and modeling the disease in two mouse models the researchers were able to appreciate the spectrum of clinical conditions that mutations in the same gene can cause.

"This is the first time a mutation of a gene in the spliceosome has been described to result in an entire spectrum of clinical conditions," Xu said. "To explain why our patient presented only with vision problems, we hypothesized that the mutation in our patient's CWC27 was milder than those of other patients. By analyzing the results on mouse models and patient samples, we found that the mutant gene in our patient probably retains a residual function, while the genes in the patients of the other groups have a more severe loss of function."

"This study also shows the power of collaboration within the genetics community when looking for new disease-associated genes," Xu said. "Initially, we only identified one patient and then we collected more cases via two platforms, GeneMatcher and the European Retinal Disease Consortium. We would not have been able to present this interesting story without the contributions of researchers from nine countries. With exome sequencing accessible to more patients and researchers, these platforms will most likely speed up the process of finding the genetic causes of human diseases."

Explore further: Improving the view on the genetic causes of retinitis pigmentosa

More information: Mingchu Xu et al. Mutations in the Spliceosome ComponentCWC27Cause Retinal Degeneration with or without Additional Developmental Anomalies, The American Journal of Human Genetics (2017). DOI: 10.1016/j.ajhg.2017.02.008

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Researchers have uncovered new genetic clues to understanding IgA nephropathy (IgAN), or Berger's disease, an autoimmune kidney disease and a common cause of kidney failure. The findings are relevant to IgAN as well as other ...

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Mutations in CWC27 result in a spectrum of developmental conditions - Medical Xpress

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We Can Now Use DNA To Store Everything From A Movie To An … – Co.Exist

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In the 1995 cyberpunk thriller Johnny Mnemonic, Keanu Reeves stars as a man whose childhood memories have been wiped so his brain can be used to smuggle data. It's all very mid-'90s dystopia, but it the premise, as it turns out, isn't too far-fetched: In a new study, scientists have demonstrated that it's possible to use DNA to store all kinds of data, including movies.

In Johnny Mnemonic, the smuggling was done with a chip implanted in the brain, which is pretty quaint compared to this new technique, which involves writing the information into the DNA itself. DNA is designed to carry data and replicate it without error, after all, so it would seem to be a perfect storage medium.

The researchers, from the New York Genome Center and the Center for Computational Biology and Bioinformatics at Columbia, wrote six different files into DNA: a computer operating system, a French movie, an image of the Pioneer plaque, a study by information theorist Claude Shannon, a computer virus, and an Amazon gift card.

To begin with, the researchers mapped pieces of computer informationthe ones and zeros that make up any digital fileonto DNA nucleotides. They then synthesized those organic molecules into DNA strands and stored the DNA in a test tube. To extract the information, they sequenced that DNA (the same way you'd sequence any DNA). What they got back was a perfect copy of the original data.

This is obviously an incredible discovery, and it has a definite purpose beyond making the plot of a sci-fi movie a little more plausible. DNA is designed for storage, and it turns out to be way better at it than anything we have invented ourselves.

"DNA has several big advantages," study co-author Yaniv Erlich told Research Gate. "First, it is much smaller than traditional media. In fact, we showed that we can reach a density of 215 petabytes per gram of DNA! Second, DNA lasts for an extended period of time, over 100 years, which is orders of magnitude more than traditional media." To put that in perspective, one petabyte is 1,000 terabytes: roughly 16,000 times the data that your 64GB iPhone can store. DNA can store 215 petabytes in just 0.035 ounces.

DNA has another big advantage over any other storage medium: It's future-proof. Do you have any old floppy disks laying around? Cassette tapes of music, or vinyl records? All of those are impossible to play unless you have the original machine to do it. These appliances may be available now, but who knows how easy it will be to find them in another few decades (or centuries)? DNA, on the other hand, "has been around for 3 billion years," Erlich said, "and humanity is unlikely to lose its ability to read these molecules."

Erlich and his research partner Dina Zielinski estimate that commercial DNA data storage won't be available for over a decade. When it is, though, the storage race may be overand, in the future, data smuggling inside your own body will be a very real and creepy possibility.

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California Bill Would Extend Taking DNA Samples To Some Misdemeanor Suspects – CBS Sacramento

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March 10, 2017 11:06 PM By Lemor Abrams

SACRAMENTO (CBS13) Its been four decades since Shirley Derryberrys 13-year-old sister Doris was killed in cold blood.

But the cold case is now over, thanks to new DNA evidence linking two cousins to the crime.

I wanted to climb across the wall and choke em but that puts me in the same category theyre in, said Derryberry.

Derryberry says the killers responsible for her sisters vicious rape and murder would not be caught today, because of new laws.

Under current state law, cops can collect DNA only from felony suspects. But under Proposition 47, many violent crimes are reduced to misdemeanors, and there are far fewer DNA samples taken.

Here we are covering for a small percentage of the population, said Assemblyman Jim Cooper.

Assemblyman Jim Cooper says he has a common sense solution. The former Sacramento County Sheriffs deputy says his proposed law would allow cops to collect DNA for crimes downgraded to misdemeanors.

When those cold cases were solvedthose homicides, rapes, vicious murders.they were solved not from that case, they got solved because they got DNA from a theft crime, or drug crime, said Cooper.

Assembly bill 16, DNA collection, is a reintroduction of Assembly bill 390, from Coopers first term. The bill failed last year, because critics argue, its unfair. The California Attorneys for Criminal Justice says, not all crimes are equal.

The government cannot collect your DNA unless theres good reason. Good justification. If they have evidence absolutely we understand that, said Ignacio Hernandez, a lobbyist for the California Attorneys for Criminal Justice.

Cooper says stories like this is reason enough. Shirely Derryberrys sister never made it past middle school. And her parents died wondering who killed their little girl.

Shell always be in my heart, said Derryberry.

Shirley Derryberry will be testifying at the bills first committee hearing next Tuesday.

Twitter: @LemorAbrams Email: labrams@kovr.com Instagram: LemorAbrams Lemor Abrams is an Emmy-Award winning news reporter, who has interviewed thousands of people, from key political figures to everyday folks who impact their community. Her very...

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California Bill Would Extend Taking DNA Samples To Some Misdemeanor Suspects - CBS Sacramento

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What DNA Ancestry Testing Can (and Can’t) Tell You – YES! Magazine

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As a descendant of enslaved Africans, Ive always wondered where on the massive continent does my family have its roots. As I aged, I became more uneasy with the phrase descendant of enslaved Africans. Where in Africa and from whom, specifically? Millions of people from several different regions were brought to this land.

More than 20 years ago, my mother and aunt started a process of finding these answers. My mother then was excited to tell me about a man named Cupid, a not-so-distant relative.

The Rev. Cupid Aleyus Whitfield was born in 1868 to Cato and Amanda Whitfield, former slaves of Gen. William Gilchrist of Gadsden County, Florida. When he was about 16 years old, Cupid began teaching at a primary school and became known as one of the leading colored teachers in Gadsden County. He married Rebecca Zellene Goodson in 1889, and they had either nine or 14 children, depending on the source consulted.

My mother and aunt learned their father, Charlie Whitfieldmy grandfatherwas one of Cupids grandsons. This is all that I know of my maternal grandfathers lineage. Of my maternal grandmothers, I know even less.

Of my paternal family, I knew only my fathers name, and even after I met him in the late 1980s, that was still all that I knew. I never met his mother, father, or his siblings, and did not know their names. He passed away in April 2006, and I didnt learn about his death until months later. But I still wanted to know more about him. And so I began my search.

Unlike my mother and aunts experience of uncovering information to fill in the many blanks in our family tree, I have the privilege of Google, ancestry websites, and DNA testing companies that emerged in the early 2000s. This new technology is revolutionary for folks like me, who want to know not only where they come from but also from whomgenealogical researchers, adoptees searching for family members, and folks tracing family trees, particularly African American families that had been displaced by slavery.

In her decade-long fieldwork to learn how the new technology impacts the way people self-identify, Alondra Nelson, Columbia University professor of sociology, says she found so much more. Her latest book, The Social Life of DNA: Race, Reparations, and Reconciliation After the Genome, explores the way in which DNA is being used as a tool for racial reconciliation.

I spoke with Nelson about what DNA science might offer social change.

Zenobia Jeffries: You open your book with the story of the Grandmothers of the Plaza de Mayo, the human rights organization that helps find children who were stolen and illegally adopted after their mothers were killed during the Argentine Dirty War. You later tell how DNA was unsuccessfully used in a reparations case here in the United States. How can science help answer fundamental questions about social justice and equality?

Alondra Nelson: The Argentina story shows us that science can help. In that case youre talking about grandparents and grandchildren. When youre doing a match, that sort of genetic line is actually pretty close. When youre talking about the experience of people of African descent, theres a gap of hundreds of years; you have a bigger mystery and a technical hurdle because youre dealing with the history of the slave trade. In post-apartheid Africa, you have families who have not been able to do burial rites for members of their [families] who died in the apartheid struggle. I think to be able to identify the remains of a specific loved one, and to be able to commemorate, bury, and memorialize that person is really powerful. Science can help with that identification, but we need to have some complicated conversations. Science cant be our moral compass.

Jeffries: What implication does DNA testing have for understanding racial and ethnic identity?

Nelson: Its complicated. The tests are far from definitive. The companies use different databases and make different kinds of mathematical and statistical assumptions. Those formulas and algorithms are their trade secrets, so theyre under no obligation to share them with other countries. So, what we think about in an academic setting, when you think about something being scientifically valid, it means that you can replicate it, you can verify it; [if] someone else does the same experiment or uses the same genetic sample from you and puts it in their database, theyll get the same results. With these companies, we dont have any of those kind of gold standards of what we might consider academic research science.

That said, for communities like African Americans, they are in many cases left without any other way to think about that. Though we have some communities whove been able to use food and linguistic ties, like the Gullah/Geechee communities, who link to contemporary Sierra Leone through linguistic ties. But those cases are less common.

And so you have a large swath of people who want to know and who are willing to try different ways of knowing. It can help to the extent that, regardless of whether youre of African descent, youve seen the reality television showspeople get a test, and it gives them sometimes new information, sometimes surprising information, or sometimes it just confirms or underscores what they already thought they knew.

Jeffries: Some tests break down ones percentage of ethnicity. But does knowing that bring us closer or divide us further when you talk about the struggle toward racial justice?

Nelson: A test that says youre this percent of this or this percent of that is making not a historical or factual assumption; its making a statistical and probabilistic assumption. So, what does it mean if a test says youre either 100 percent or 30 percent Nigerian? That means theyve created some algorithm that they assume is 100 percent Nigerian. But what in the world would that be? The history of human history is one of intermixing, intermarriage, intermating.

I use the phrase genealogical aspirations because the questions that people have in agreeing to the testing experience sort of shape what it can mean for them. If its important for you to know what part Norwegian you are versus what part Russian, then youre going to be interested in how you slice those things up. But if youre more interested in whether youre more European or more bio-geographically mixed, then you have a different read of what the tests are.

For me, whats important is not so much that these types of tests give you the truth of who you are, your identity, but that they suggest how we have come to think about putting human beings in buckets. None of these categories means anything outside of culture and history.

Jeffries: You say DNA can be used as a tool in the struggle for racial justice. Is using it for genealogical research part of that struggle?

Nelson: Sure. For people of African descent who feel incomplete without having that information about their African ancestry, it becomes very empowering.

Whether were talking about genetics or identity, we know that social movements and social activism come out of a sense of empowerment and agency. And like-minded people who feel empowered and outraged about the way things are can change things. That empowerment comes to some through the use of these tests is part of what mobilizes them for social justice issues.

Jeffries: For the companies that own these databases, is there something to be said about the politics of privacy and the ethics of who keeps our DNA?

Nelson: Different companies do different things. Often the consent forms you sign when you do one of these tests look like the consent that you sign when youre uploading a new operating systemtheres a lot of small words and people dont really read it. We know, for example, that some companies keep all of your data, because when youre dealing with millions of genetic markers, the bigger your databases are, the more reliable statistically speaking your findings can be.

And now that some companies are interested, not only in genetic ancestry testing but also in pharmaceutical developments, this data becomes really important. Theyre using peoples genetic samples to try to do investigations and for the development of personalized medicine and protocols.

But then you have the new genetic genealogy 2.0 thats been happening: the ability for people to upload their markers online, to make them available to other geneticists.

On one website you can fill out as much as you can of your family tree and also upload your genetic genealogy results so that other people can see them or people can contact you. On the one hand, theres two different competing interests here: One is people wanting to know more about their genealogy and their genetic genealogy, which might cause them to reveal information to other people. But then theres also this real necessary interest in privacy and the desire for privacy.

Someone might think, Well, Im just using this to do my genealogy. But that same data could be used to reveal things about your medical profile or could be used potentially to implicate people in the criminal justice system.

The thing about DNA thats different from other kinds of data is that it can be useful in all of these different social and political sitesthe exact same data, the exact same samples, potentially. Thats where the portability and transitive nature of DNA technology is the concern.

Im not trying to paint a dystopic future, but I think its something to worry about. Genetic data carries a lot of information that can be used simultaneously in a lot of different places for purposes for which people intend it to be used, and purposes that they do not.

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Police use DNA from burglar’s mask to solve years-old case – fox2now.com

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Authorities identified 26-year-old Javon Winston as their main suspect in a home burglary off Glades Avenue in Richmond Heights back in August 2014.

Court documents stated the homeowner came home to find all the rooms rummaged through and evidence of forced entry. While police were on the scene, Winston was seen running from the house, leaving behind a surgical mask that he was wearing.

Which our responders identified as a possible source of DNA and it was entered into the system and eventually we did get the suspect identified," said Captain Craig Mueller, Richmond Heights Police Department.

"It could be saliva, hair, or skin, anything that they leave behind. Maybe if they even breathe into a mask and left a skin particle somewhere and we take it over to the lab, they do a fantastic job of getting those processed for us."

Mueller said even though it may have taken a while before authorities identified Winston, there is a reason for it.

"Not everyone's DNA is in the DNA system, so we may get evidence at a crime scene and think we have DNA on it, however that suspects DNA might not be in the system, he said. It might be a year later before his or her DNA gets in the system and we make a match."

Mueller said it used to be that fingerprints were the way to go, but more and more officers are being trained in how to utilize advanced DNA technology.

"It's a much smaller database, he said. But as people start getting DNA and putting it in the system, it's getting more and more effective for us to fight crime. All Richmond Heights patrol officers, whether they are detectives or just the guy on the street, gets initial DNA skills.

Mueller added that, to a certain degree, there is the notion of what some citizens may see happening in TV crime dramas and compare it to real life crime solving.

"I think some people watch CSI TV shows and they think, You can just put somebody in andboomyou get an identification, he said. The wheels of justice go a little slowly, so just because we might not solve a crime that day, or somebody might not be in custody that week, it doesn't mean that we have forgotten about the case. So sometimes we get a little bit lucky or sometimes it's hard work from our detectives.

Mueller said the goal for law enforcement agencies is to try and eliminate the one year delay, meaning continuing to train officers in how to use the DNA database as it becomes bigger.

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Police use DNA from burglar's mask to solve years-old case - fox2now.com

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Helix Picks Eleven to Help Introduce Consumers to the Future of DNA Sequencing – Adweek

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The future is in your genes.

Bay Area startup Helix believes that individual DNA genomes hold the key to mastering the digital economy, and many investors agree. The company, which launched last fall as a spinoff of genetic research giant Illumina on the strength of $100 million in private funding, wants to help all sorts of companies sell their products by using genetics as the ultimate targeting tool.

Now, Helix has chosen Eleven as its agency of record to help bring that message to the public after a review that included 10 agencies in the RFP phaseand three in the final round. The independent San Francisco shop will lead all branding and national advertising efforts for the company moving forward.

We truly believe that the next great discovery is youthe personal genetic story you have within. And we want to empower every person to tap into this knowledge and improve his or her life through DNA, said Helix CEO Robin Thurston in a statement. Thats why were building a platform for responsible DNA products, furthering the understanding of DNA for peoples everyday lives.

Helix has developed two products: One is a service that can map your personal DNA genomeand its billions of individual pointsin a matter of weeks, and the other is a platform that uses that profile to help consumers manage different aspects of their lives, allowing brands to create and market products tailored to a persons very specific needs.

Think of it as an app store driven by the genetic markers that make you unique among the planets 7.4 billion people.

Regarding his agencys newest client, Eleven CEO CourtneyBuechert said, The Helix protocol is to map my entire genome so I only have to be tested once. After sequencing for this data set, they will become a marketplace for specific providers.

Examples of such providers range from weight loss companies targeting individuals based on their genetic predispositions to a business that uses genes to recommend wines. The latter company already exists, and Buechert predicts that the biotech boom led by companies like Helix, 23andMe and Ancestry.com will soon be equal to or greater than consumer tech. One key difference between Helix and the latter businesses is that it doesnt simply test for genealogy; its technology can theoretically measure ones propensity for inherited illnessesor help athletes better learn how to maximize their performance potential.

Elevens first work for the brand, which should debut later this year, will be aimed at general market consumers rather than business-to-business audiences. The nature and scope of the work has not yet been determined, though Buechert said that content will be key and that Elevens ability to provide both creative and analytical services played a key role in the win.

Eleven has experience launching brands that build lasting and meaningful relationships with customers, and that aligns with our values at Helix, said Thurston in explaining his companys choice. They have a track record of bringing warmth and humanity to technology and brand thinking that goes beyond advertising, and can help guide how we think and talk about ourselves internally and with partners. We look forward to working with them on our story.

Elevens current roster includes Oakley, Dignity Health, Visa and its oldest client, Apple.

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