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SpcaeX cargo ship returns from International Space Station Sunday – WIAT 42

Posted: March 19, 2017 at 4:00 pm


WIAT 42
SpcaeX cargo ship returns from International Space Station Sunday
WIAT 42
After delivering about 5,500 pounds of cargo, the SpaceX Dragon cargo spacecraft is set to leave the International Space Station on Sunday, March 19.
SpaceX's Dragon cargo spacecraft all set to leave space station on ...Zee News

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Space Station Shut-Eye: New LED Lights May Help Astronauts (and You) Sleep Better – Space.com

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Astronauts on the International Space Station are swapping out their fluorescent light bulbs for a fancy new set of light-emitting diodes (LEDs)that scientists think will help them sleep better and be more alert. If the new lights work as intended, the technology could help people on Earth sleep better as well.

The intensity and colors of the light emitted by the new Solid-State Light Assemblies (SSLAs) can produce millions of different spectra of light. Three settings will help to create a lighting environment that can either increase alertness, promote sleepiness or provide normal "daylight" that will help astronauts see clearly during normal work hours.

Because the space station circles the Earth every 92 minutes, astronauts on board can see the sun rise and set 16 times in a day. While it might sound delightful to watch pretty sunrises and sunsets all day, this rapid cycle of day and night can throw astronauts' sleep schedules out of whack. Add to that a demanding work schedule with occasional night shifts, and the astronauts are bound to experience some insomnia. [Sleeping in Space: How Astronauts Do It]

Solid-State Light Assemblies (SSLAs) are replacing old lighting technology aboard the International Space Station. These lights offer more efficient, longer-lasting lighting options, as well as provide crewmembers with the ability to adjust lighting intensity based on the time of day, promoting a more conducive environment for both sleep and alertness.

In fact, research has shown that astronauts don't get enough sleep. On average, they sleep about 6 hours per night, while their schedules allot 8.5 hours. As a result, sleeping pills and caffeine are popular commodities among space travelers.

On Earth, the human body naturally operates on a 24-hour schedule called a circadian rhythm. Our biological clocks depend on a regular pattern of sunlight and darkness to keep that rhythm going. In space, astronauts depend on artificial lighting to regulate their sleep-wake schedules. But it's not just the timing of the light that matters on the space station the type of lights used can make a big difference when it comes to keeping sleep schedules on track.

Fluorescent light bulbs and LEDs are prized for being energy-efficient, but the light they produce can contribute to insomnia. Both emit blue light, which promotes alertness while decreasing the amount of the natural sleep hormone melatonin. While blue light may be helpful in the mornings, exposure to blue light closer to bedtime can make falling asleep more difficult.

The new SSLAs that are being installed inside the space station contain LEDs, but with the adjustable light spectrum, blue light at night will no longer pose a problem. Before bedtime, the new lighting system will emit a spectrum of light without the smaller wavelengths of blue and violet light. When it's time to wake up again, the light spectrum will include that element of the spectrum to promote alertness. This can help astronauts reset or maintain a healthy circadian rhythm and, in turn, make them more productive on the job.

Expedition 18 Commander, Mike Fincke, holding an early version of a solid state lighting assembly (the general luminaire assembly or GLA) that is part of the Lighting Effects investigation. Equipment for that investigation will fly toward the space station aboard a Cygnus spacecraft on Oct. 14, 2016.

Astronauts began replacing the old fluorescent General Luminaire Assemblies in August, and the transition is still ongoing. Meanwhile, NASA has been studying how the new lights are affecting the astronauts through the Lighting Effects Study.

"The system can provide millions of different light spectra," Steven Lockley, a sleep specialist at Brigham and Women's Hospital and co-investigator for the Lighting Effects Study, said in a statement. "Were not making the ISS into a disco, but we are going to use three different light settings. We'll use a general light setting that provides a good light to see by during normal work, a higher-intensity blue light enriched setting that elevates alertness and can better shift the circadian clock when needed, and a lower-intensity blue wavelength-depleted 'pre-sleep' setting to calm the brain and promote sleep."

Results from the sleep study will help flight planners optimize lighting schedules for astronauts during spaceflight, but it can also help people on Earth gain control of their sleeping patterns.

"Study results should make it clear exactly when and how to use these various settings of light intensity and spectrum," NASA officials said in the statement. "These results could also lead to Earth-based benefits such as helping manage sleep patterns for shift workers, or even developing treatments for sleep disorders or jet lag."

Email Hanneke Weitering at hweitering@space.com or follow her @hannekescience. Follow us @Spacedotcom, Facebookand Google+. Original article on Space.com.

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Contacting the space station – Peru Tribune

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Students at Blair Pointe Elementary experienced a once in a lifetime opportunity last week as they were able to have a live chat with astronaut Shane Kimbrough, who is currently living and working abroad the International Space Station (ISS).

The assembly was held at the Peru High Schools auditorium where seats were filled by the third-through-sixth-graders as well as many community leaders who were in attendance.

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Contacting the space station - Peru Tribune

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China gearing up for launch of first cargo spacecraft to support future … – SpaceNews

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Long March 7 rocket lifting off June 25, 2016. Credit: CMSE

China is gearing up for the launch of its first cargo spacecraft intended to support a future space station.

The Long March 7 rocket that will launch the Tianzhou-1 spacecraft arrived last week at the Wenchang launch site for a launch planned for the latter half of April.

Tianzhou-1 will dock with the uncrewed Tiangong-2 module currently in orbit and test the ability to transfer propellant between the spacecraft and the module.

The launch will be the first for the Long March 7 since its inaugural flight last June carrying a set of experimental payloads. [gbtimes]

More News

NASA is planning to make decisions in the coming months on development of a gateway outpost in cislunar space.At a conference last week, NASAs Bill Gerstenmaier said that the agency will make some pretty crisp decisions in the coming months on what kinds of payloads to fly on future SLS missions that could support development of the outpost. The facility is part of NASAs long-term strategy to support human missions to Mars in the 2030s, but companies that have developed their own concepts for such an outpost, as part of NASAs NextSTEP program, say that the outpost could also support human missions to the surface of the moon by the U.S. or other nations. [SpaceNews]

Vice President Mike Pence met with Buzz Aldrinon Fridayto discuss space policy.In a tweet, Pence said he met with Aldrin at the White House as we work to shape the space policy of our administration. Neither Aldrin not the White House provided additional details about the meeting. In policy statements before the election, the Trump campaign said it would re-establish the National Space Council, which in the past has been led by the vice president. [Space.com]

Lockheed Martin has retired the Athena rocket.Steve Skladanek, president of Lockheed Martin Commercial Launch Services, said at the Satellite 2017 conference last week that the company does have one remaining Athena rocket in storage, but is not actively marketing it. The last Athena launch was in 2001, but Lockheed tried to revive the rocket several years ago to tap into the growing smallsat market.Skladanek also said that Lockheed, which markets the Atlas 5 to commercial customers, expects that vehicle to remain available for about five years after the introduction of the Vulcan rocket as the new rocket builds up its flight rate. [SpaceNews]

Planet unveiled an online tool that combines maps with imagery from its satellite constellation.Planet Explorer Beta, a free online tool, is designed to demonstrate the the ability of satellite imagery to track changes in regions over time. Planet currently operates 149 satellites, including 144 Dove cubesats and five larger RapidEye satellites, that collect 50 million square kilometers of imagery a day. [SpaceNews]

Boeing has successfully tested the parachute system for its CST-100 Starliner commercial crew vehicle.The test, carried out at Spaceport America in New Mexico, used a balloon to carry a mockup of the CST-100 crew capsule to an altitude of more than 12,000 meters. The capsule then dropped from the balloon and deployed a series of parachutes for a safe landing. Boeing plans a few more drops to complete qualification of the parachutes for flight. [Spaceport America]

Space Florida has approved a loan for OneWebs satellite manufacturing plant.The state space development agency arranged the loan for OneWeb through SunTrust Bank, and the Space Florida board approved the loanFriday. That loan, as well as state incentives, will be used to support construction of the factory outside the Kennedy Space Center gates, where OneWeb will build hundreds of its broadband communications satellites. A formal groundbreaking was planned for earlier this month but postponed because of what the company said was a scheduling conflict. [Florida Politics]

The Space Data Association (SDA) will work with Analytical Graphics Inc. (AGI) to upgrade commercial space situational awareness capabilities.SDA announced last week it will partner with AGI tocreate an updated Space Data Center Space Traffic Management service, called SDC 2.0. The updated system is intended to provide more accurate information on the orbital locations of satellites of SDA member companies in order to provide better warnings of potential collisions. [SpaceNews]

Hughes Network Systems has won a contract to provide satellite communications services for British drones.The multi-million-dollar contract covers communications for the British militarys fleet of Predator B drones. The services will initially use X-band frequencies through the U.K.s Skynet 5 satellites, but is also designed to work with other satellites in other frequency bands. [SpaceNews]

Cheap satellite terminals, and not constellations of satellites, may be key to opening new markets for internet access.Executives at the Satellite 2017 conference last week said lowering the price of satellite terminals to less than $100 each is key to providing service in the developing world. Also sought are inexpensive flat-panel antennas that can be used on planes and other vehicles. [SpaceNews]

The movie about the life of Neil Armstrong has a release date, but youll need to be patient.First Man, the film about Armstrong based on the biography of the same name, is set to be released onOct. 12, 2018. The movie will be directed by Damien Chazelle, who won the Oscar for best director last month forLa La Land, and will star Ryan Gosling as Armstrong. [Space.com]

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China gearing up for launch of first cargo spacecraft to support future ... - SpaceNews

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NASA’s humanoid robot put to the test for ultimate Mars challenge … – RT

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Published time: 19 Mar, 2017 02:42

NASAs Robonauts are being put to the test in Mars-like obstacle courses in order to pave the way for future humanoid space exploration and help bridge the expansive gap between Earth and human colonization of the red planet.

NASAbuilt four six-foot, 290-pound, Iron man-like pieces of machinery named Valkyrie, at the cost of about $2 million each, and then outsourced three of them to universities to test the robots capabilities in various hostile environments.

In 2015 Northeastern University, Massachusetts Institute of Technology and Scotlands University of Edinburgh were all chosen in open competition and assigned the task of challenging and refining the robotic technology in the hope of creating a future robot capable of withstanding the Martian planet.

READ MORE: R&D boot camp: NASAs humanoid robots go to universities for special space training

Northeastern tested their model at the New England Robotics Validation and Experimentation (NERVE) Center a warehouse filled with large and challenging obstacle courses designed to test robots and drones alike.

Its in this kind of environment that robotics and engineering students put Valkyries skills to the test and have further developed its high-level capabilities.

She can autonomously make decisions, move around and accomplish tasks, said Northeastern PhD student, Murphy Wonsick to TechCrunch.

In theory, the successors to these Robonauts would help facilitate the colonization of Mars by building the necessities humans need before their arrival and further assisting the astronauts with tasks while on the red planet.

READ MORE: The power of glove: GM & NASA create robotic helping hand to fight fatigue (VIDEO)

The robots ultimate Mars test will take place this summer when 20 teams will compete for a $1 million prize in NASAs Space Robotics Challenge, designed to place Valkyrie in a Martian-like scenario.

In the not too distant future, R5 has arrived on Mars along with supplies ahead of a human mission. Overnight a dust storm damaged the habitat and solar array, and caused the primary communication antenna to become misaligned, the agencys simulated event suggests.

The robot must repair the damage, deploy a new solar panel and align the communication antenna to complete the challenge.

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NASA's humanoid robot put to the test for ultimate Mars challenge ... - RT

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From skin to brain: Stem cells without genetic modification: Study … – Science Daily

Posted: at 3:59 pm


Science Daily
From skin to brain: Stem cells without genetic modification: Study ...
Science Daily
A discovery, several years in the making, demonstrates that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic ...

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From skin to brain: Stem cells without genetic modification: Study ... - Science Daily

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From skin to brain: Stem cells without genetic modification – Phys.Org

Posted: at 3:59 pm

March 15, 2017 by Grove Potter The four images, from left to right, show Keratinocyte-derive neural crest stem cells turning into neurons as shown by typical neuronal morphology. Credit: University at Buffalo.

A discovery, several years in the making, by a University at Buffalo research team has proven that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain.

The practical implications could be very significant, from studying genetic diseases in a dish to generating possible regenerative cures from the patient's own cells.

"It's actually quite remarkable that it happens," says Stelios T. Andreadis, PhD, professor and chair of UB's Department of Chemical and Biological Engineering, who recently published a paper on the results in the journal Stem Cells.

The identity of the cells was further confirmed by lineage tracing experiments, where the reprogrammed cells were implanted in chicken embryos and acted just as neural crest cells do.

Stem cells have been derived from adult cells before, but not without adding genes to alter the cells. The new process yields neural crest cells without addition of foreign genetic material. The reprogrammed neural crest cells can become smooth muscle cells, melanocytes, Schwann cells or neurons.

"In medical applications this has tremendous potential because you can always get a skin biopsy," Andreadis says. "We can grow the cells to large numbers and reprogram them, without genetic modification. So, autologous cells derived from the patient can be used to treat devastating neurogenic diseases that are currently hampered by the lack of easily accessible cell sources."

The process can also be used to model disease. Skin cells from a person with a genetic disease of the nervous system can be reprogrammed into neural crest cells. These cells will have the disease-causing mutation in their chromosomes, but the genes that cause the mutation are not expressed in the skin. The genes are likely to be expressed when cells differentiate into neural crest lineages, such as neurons or Schwann cells, thereby enabling researchers to study the disease in a dish. This is similar to induced pluripotent stem cells, but without genetic modification or reprograming to the pluripotent state.

The discovery was a gradual process, Andreadis says, as successive experiments kept leading to something new. "It was one step at a time. It was a very challenging task that took almost five years and involved a wide range of expertise and collaborators to bring it to fruition," Andreadis says. Collaborators include Gabriella Popescu, PhD, professor in the Department of Biochemistry in the Jacobs School of Medicine and Biomedical Sciences at UB; Song Liu, PhD, vice chair of biostatistics and bioinformatics at Roswell Park Cancer Institute and a research associate professor in biostatistics UB's School of Public Health and Health Professions; and Marianne Bronner, PhD, professor of biology and biological engineering, California Institute of Technology.

Andreadis credits the persistence of his then-PhD student, Vivek K. Bajpai, for sticking with it.

"He is an excellent and persistent student," Andreadis says. "Most students would have given up." Andreadis also credits a seed grant from UB's office of the Vice President for Research and Economic Development's IMPACT program that enabled part of the work.

The work recently received a $1.7 million National Institutes of Health grant to delve into the mechanisms that occur as the cells reprogram, and to employ the cells for treating the Parkinson's-like symptoms in a mouse model of hypomyelinating disease.

"This work has the potential to provide a novel source of abundant, easily accessible and autologous cells for treatment of devastating neurodegenerative diseases. We are excited about this discovery and its potential impact and are grateful to NIH for the opportunity to pursue it further," Andreadis said.

The research is described in the journal Stem Cells under the title "Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates."

Explore further: Embryonic gene Nanog reverses aging in adult stem cells

More information: Vivek K. Bajpai et al, Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates, STEM CELLS (2017). DOI: 10.1002/stem.2583

Journal reference: Stem Cells

Provided by: University at Buffalo

The fountain of youth may reside in an embryonic stem cell gene named Nanog.

Caltech scientists have converted cells of the lower-body region into facial tissue that makes cartilage, in new experiments using bird embryos. The researchers discovered a "gene circuit," composed of just three genes, that ...

Scientists at the University of Newcastle, UK, have used a combination of small molecules to turn cells isolated from human skin into Schwann cells - the specialised cells that support nerves and play a role in nerve repair. ...

Johns Hopkins stem cell biologists have found a way to reprogram a patient's skin cells into cells that mimic and display many biological features of a rare genetic disorder called familial dysautonomia. The process requires ...

(Phys.org)A team of researchers affiliated with New York and Dalhousie Universities, in the U.S. and Canada respectively, has found a possible intermediate cell type that might help understand the evolutionary process ...

German researchers succeed in obtaining brain and spinal cord cells from stem cells of the peripheral nervous system.

Adolescence marks not only the period of physical maturation bridging childhood and adulthood, but also a crucial period for remodeling of the human brain. A Penn study reveals new patterns of coordinated development in the ...

(Phys.org)A trio of researchers from the U.K., the Netherlands and the U.S. has filmed a grown female chimpanzee cleaning her son's teeth after he died. In their paper published in the journal Scientific Reports, Edwin ...

It's a good thing we don't have to think about putting all the necessary pieces in place when one of our trillions of cells needs to duplicate its DNA and then divide to produce identical daughter cells.

Biologists who study the malaria mosquito's 'nose' have found that it contains a secondary set of odor sensors that seem to be specially tuned to detect humans. The discovery could aid efforts to figure out how the insects ...

Even plants have to live on an energy budget. While they're known for converting solar energy into chemical energy in the form of sugars, plants have sophisticated biochemical mechanisms for regulating how they spend that ...

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From skin to brain: Stem cells without genetic modification - Phys.Org

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Stem Cells Reprogrammed without Genetic Modification – Technology Networks

Posted: at 3:59 pm

A discovery, several years in the making, by a University at Buffalo research team has proven that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain.

The applications could be very significant, from studying genetic diseases in a dish to generating possible regenerative cures from the patients own cells.

Its actually quite remarkable that it happens, says Stelios T. Andreadis, PhD, professor and chair of UBs Department of Chemical and Biological Engineering, who recently published a paper on the results in the journal Stem Cells.

The identity of the cells was further confirmed by lineage tracing experiments, where the reprogrammed cells were implanted in chicken embryos and acted just as neural crest cells do.

Stem cells have been derived from adult cells before, but not without adding genes to alter the cells. The new process yields neural crest cells without addition of foreign genetic material. The reprogrammed neural crest cells can become smooth muscle cells, melanocytes, Schwann cells or neurons.

In medical applications this has tremendous potential because you can always get a skin biopsy, Andreadis says. We can grow the cells to large numbers and reprogram them, without genetic modification. So, autologous cells derived from the patient can be used to treat devastating neurogenic diseases that are currently hampered by the lack of easily accessible cell sources.

The process can also be used to model disease. Skin cells from a person with a genetic disease of the nervous system can be reprogrammed into neural crest cells. These cells will have the disease-causing mutation in their chromosomes, but the genes that cause the mutation are not expressed in the skin. The genes are likely to be expressed when cells differentiate into neural crest lineages, such as neurons or Schwann cells, thereby enabling researchers to study the disease in a dish. This is similar to induced pluripotent stem cells, but without genetic modification or reprograming to the pluripotent state.

The discovery was a gradual process, Andreadis says, as successive experiments kept leading to something new. It was one step at a time. It was a very challenging task that took almost five years and involved a wide range of expertise and collaborators to bring it to fruition, Andreadis says. Collaborators include Gabriella Popescu, PhD, professor in the Department of Biochemistry in the Jacobs School of Medicine and Biomedical Sciences at UB; Song Liu, PhD, vice chair of biostatistics and bioinformatics at Roswell Park Cancer Institute and a research associate professor in biostatistics UBs School of Public Health and Health Professions; and Marianne Bronner, PhD, professor of biology and biological engineering, California Institute of Technology.

Andreadis credits the persistence of his then-PhD student, Vivek K. Bajpai, for sticking with it.

He is an excellent and persistent student, Andreadis says. Most students would have given up. Andreadis also credits a seed grant from UBs office of the Vice President for Research and Economic Developments IMPACT program that enabled part of the work.

The work recently received a $1.7 million National Institutes of Health grant to delve into the mechanisms that occur as the cells reprogram, and to employ the cells for treating the Parkinsons-like symptoms in a mouse model of hypomyelinating disease.

This work has the potential to provide a novel source of abundant, easily accessible and autologous cells for treatment of devastating neurodegenerative diseases. We are excited about this discovery and its potential impact and are grateful to NIH for the opportunity to pursue it further, Andreadis said.

The research, described in the journal Stem Cells under the title Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates, was supported by grants from the National Institutes of Health.

Reference:

Bajpai, V. K., Kerosuo, L., Tseropoulos, G., Cummings, K. A., Wang, X., Lei, P., Liu, B., Liu, S., Popescu, G. K., Bronner, M. E. and Andreadis, S. T. (2017), Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates. Stem Cells. doi:10.1002/stem.2583

This article has been republished frommaterialsprovided by University at Buffalo. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Drosophila effectively models human genes responsible for genetic kidney diseases – Science Daily

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Drosophila effectively models human genes responsible for genetic kidney diseases
Science Daily
"For the first time, we realized that the functions of essential kidney genes could be so similar from the flies to humans." A logical next step will be to generate more personalized in vivo models of genetic renal diseases bearing patient-specific ...

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Drosophila effectively models human genes responsible for genetic kidney diseases - Science Daily

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Mouse study helps find causes of human behavioral disorders – Baylor College of Medicine News (press release)

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Scientists studying the role of a protein complex in the normal development of the mouse brain unexpectedly created a mouse model that replicates clinical symptoms of patients with complex neurological disorders such as hyperactivity, learning deficits and social behavior abnormalities. Careful study of this mouse model led to the discovery of the genetic cause of the human neurological condition of five patients who, until now, had not received a genetic diagnosis. The team, which includes researchers, from Baylor College of Medicine, Texas Childrens Hospital and other institutions, has published the results in Nature Genetics.

When we began this research, we were just curious about what the ATXN1-CIC complex normally does, said senior author Dr. Huda Zoghbi, professor of molecular and human genetics and of pediatrics - neurology and developmental neuroscience at Baylor and director of the Jan and Dan Duncan Neurological Research Institute at Texas Childrens Hospital.

The researchers knew that enhanced function of the ATXN1-CIC complex can lead to neurodegenerative conditions. In this work, to discern the role of the complex in the development of a normal brain, they explored the biological consequences of the opposite situation, the complex losing its function. Using genetic tools in the lab, the researchers selectively removed genes involved in the formation of the complex in distinct regions of the mouse brain; the forebrain, and the hypothalamus and amygdala.

We discovered that genetically removing the complex from forebrain cells resulted in learning and memory deficits and hyperactivity in the mice, said co-first author Dr. Qiumin Tan, postdoctoral fellow of molecular and human genetics in the Zoghbi lab. Interestingly, within the forebrain, only the upper layers of the cortex showed a reduction of thickness, while lower layers appeared intact.

The biggest surprise was how the fairly specific and relatively limited changes in the cortex caused dramatic hyperactivity in mice, said co-first author Dr. Hsiang-Chih Lu, who was a doctoral student in the Zoghbi lab during this study and is currently at Washington University.

When the researchers knocked out genes involved in the protein complex only in the hypothalamus and amygdala, they observed changes in the mice behavior that were different from those described above. In this case, the mice showed prominent deficits in their social interactions, Tan said. For instance, they interacted less with other mice, and spent less time interacting with unfamiliar mice. These behaviors resemble some of the behaviors observed in individuals with autism spectrum disorders.

In contrast to the marked changes in thickness observed in the cortex, the researchers did not observe any major alterations in the structure of hypothalamus and amygdala when they lacked the protein complex.

Intrigued by their findings in mice, the researchers decided to investigate whether similar genetic changes in humans would be associated with comparable behaviors.

If we hadnt seen these neurological problems in the mice, we would not have looked for the human parallel, Zoghbi said.

The human connection

To find individuals carrying mutations in the genes involved in the formation of the ATXN1-CIC complex, the researchers entered the candidate genes they had worked with in mice in GeneMatcher, a web-tool developed as part of the Baylor-Hopkins Center for Mendelian Genomics for rare disease researchers. Similar to online dating websites that match couples, GeneMatcher allows researchers to find others that are interested in the same genes they are working on.

Through GeneMatcher we found five individuals carrying a mutation in capicua, one of the genes linked to the ATXN1-CIC complex, Tan said. Taken together, the affected individuals present with a spectrum of behavioral disorders including attention deficit/hyperactivity disorder (ADHD), developmental delay and intellectual disabilities and some have autism and epileptic seizures.

These individuals did not have an explanation for their condition; they did not know it was a genetic disorder or what had caused it. This work has provided them with an answer; researchers can now better understand the biology of their hyperactivity and intellectual disability.

Hyperactivity is a relatively common problem in children, but its been hard to understand it biologically, Zoghbi said. I think our work has pointed out an area of the brain in which we can begin to investigate to understand what drives this behavior.

Some people have suggested that mouse models are not good enough to study human diseases. I think that the models are good, what is important is how we study them, Zoghbi said. In this case, careful study of the mouse models has shown us where to look in human patients to potentially find the biological underpinnings of complex behavioral disorders, such as ADHD and autism spectrum disorder.

This work has shown that the ATXN1-CIC complex is important for proper development and function of the brain and also uncovers its roles in human neurodevelopmental disorders, Lu said.

For a complete list of the authors and their affiliations, as well as the financial support for this project go here.

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Mouse study helps find causes of human behavioral disorders - Baylor College of Medicine News (press release)

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