Page 1,950«..1020..1,9491,9501,9511,952..1,9601,970..»

Category Archives: Transhuman News

Newly-discovered ‘molecular scissors’ may help carve out new niches in genetic engineering – TASS

Posted: March 23, 2017 at 1:27 pm

Sergei Savostyanov/TASS

MOSCOW, March 22. /TASS/ Scientists discovered new types of CRISPR-CAS systems of adaptive bacterial immunity, Skoltechs press office said.

The work of joint research team from Skolkovo Institute of Science and Technology (Skoltech), the National Institutes of Health (NIH; USA) and the Massachusetts Institute of Technology (MIT; USA) was published in the journal Nature Reviews Microbiology.

In nature, CRISPR-Cas systems are used by bacteria to defend against invading viruses. In the CRISPR-Cas, bacteria store the sequences of the viral genome, so the genes of the Cas proteins act like scissors and can cut the DNA at known points. If a bacteria is attacked by a virus, it can recognize the viral DNA by means of CRISPR-Cas and then destroy it with Cas proteins. It is the ability of CRISPR-Cas system to cut DNA at exactly the predefined locations that enable it to create new technologies for genome editing, making it possible for instance to treat genetic diseases.

"Using the systematic bioinformatics search in DNA sequences from the genome databases, we predicted new systems. The genes of newly disclosed systems are quite unusual, and the CRISPR-Cas systems are unlike those studied before. We are almost sure that now all the main types of CRISPR-Cas systems have been classified," commented Sergey Shmakov, the first author of the study and Skoltech PhD student.

As a result of the evolutionary arms race between viruses and bacteria, an incredible diversity of CRISPR-Cas systems exists in nature.

In the new study, scientists performed a large-scale bioinformatics analysis and identified previously unknown types of CRISPR-Cas systems that may have a broad range of uses in the field of genetic engineering. The researchers believe that some of the discovered CRISPR-Cas systems might be applied to developing innovative tools for genome editing and regulation.

For example, the VI-B type CRISPR-Cas system has novel proteins that may regulate its activity. Another discovery, the V-U system, contains comparatively small Cas proteins which makes it highly attractive for genetic engineering purposes because it is relatively easy for bioengineers to work with small proteins and deliver them to various kinds of cells.

In other media

Excerpt from:
Newly-discovered 'molecular scissors' may help carve out new niches in genetic engineering - TASS

Posted in Genetic Engineering | Comments Off on Newly-discovered ‘molecular scissors’ may help carve out new niches in genetic engineering – TASS

Genetically modified mosquito use under consideration in Houston – CBS News

Posted: at 1:27 pm

Officials in Houston, Texas, are contemplating the use of genetically-modified mosquitoes to fight Zika and other viruses transmitted by the insect.

Jim Gathany, Scientific Photographer, Centers for Disease Control and Prevention

Officials are considering releasing genetically modified mosquitoes in Houston as part of the fight against the insects known to carry diseases such as the Zika virus.

The Houston Chronicle reports that Harris County, Texas, officials are negotiating with a British biotech company, Oxitec, to release mosquitoes that have been genetically engineered to produce offspring that die.

Oxitec has yet to try out its technology in the U.S. A proposed trial in a Florida Keys suburb never got off the ground last year amid residents concerns about genetic engineering.

Play Video

Millions of genetically-modified mosquitoes are being released in the Brazilian town of Piracicaba with the hope that they'll take out Zika-infec...

There have been no documented cases of Zika being locally transmitted in the Houston region. The only homegrown Zika cases in Texas have been in Cameron County, on the border with Mexico.

Mustapha Debboun, director of the Harris County Mosquito Control Division, said working with Oxitec could provide another tool in the fight against Zika and other mosquito-borne illnesses. Aedes aegypti mosquitoes, which carry the Zika virus, dengue fever and chikungunya, among other deadly illnesses, are common in the Houston region.

Deric Nimmo, principal scientist at Oxitec, called the release of mosquitoes to control mosquitoes an important change in the approach.

Oxitec has conducted field trials in Brazil, Panama and the Cayman Islands and says it has reduced the Aedes mosquito populations by up to 90 percent in each location.

In August, the Food and Drug Administration gave approval to a proposed field trial in Key Haven, a Florida Keys suburb, finding that it would have no significant impacts on human health, animal health or the environment. Residents in Monroe County, Florida, voted in a nonbinding resolution in favor of working with Oxitec. But Key Haven residents voted nearly 2-to-1 in November against the trial.

According to the FDA, if Oxitec wanted to conduct a field trial in Texas Harris County, the company would have to submit an environmental assessment to the agency.

2017 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.

View original post here:
Genetically modified mosquito use under consideration in Houston - CBS News

Posted in Genetic Engineering | Comments Off on Genetically modified mosquito use under consideration in Houston – CBS News

GSK & Regeneron Announce Big Gene Sequencing Initiative – Drug Discovery & Development

Posted: at 1:25 pm

UK Biobank announced a major research initiative with GSK and the Regeneron Genetics Center (RGC) to generate genetic sequence data from the 500,000 volunteer participants in the UK Biobank resource. The initiative will enable researchers to gain valuable insights to support advances in the development of new medicines for a wide range of serious and life threatening diseases.

Genetic evidence has revolutionised scientific discovery and drug development in recent years by providing clear links between genes and disease. Currently, an estimated 90% of potential medicines entering clinical trials fail to demonstrate the necessary efficacy and safety, and never reach patients. Many of these failures are due to an incomplete understanding of the link between the biological target of a drug and human disease. By contrast, medicines developed with human genetic evidence have had substantially higher success rates and patient care has benefited.

UK Biobank is the worlds most comprehensive health resource. It has been collecting information and samples from its 500,000 participants for the past ten years, and ensures that data provided to health researchers does not identify them. RGC and GSK have committed an initial investment to enable the sequencing of the first 50,000 samples, to be completed before the end of 2017. Sequencing of UK Biobanks samples will be carried out at the RGC, New York, one of the worlds largest human genetics sequencing centres. Sequencing of the full 500,000 samples in UK Biobank is expected to take three to five years.

Consistent with the founding principles of UK Biobank, these sequence data will be incorporated back into UK Biobanks resource following a standard exclusivity period for GSK and Regeneron (9 months for the initial phase) and made openly available to the broader scientific community. Research findings will also be submitted for publication in peer-reviewed journals.

Sir Rory Collins, UK Biobank Principal Investigator and BHF Professor of Medicine & Epidemiology at Oxford University, said: As a result of the altruism and continued support of our volunteer participants, UK Biobank has amassed an enormous amount of securely-stored health, lifestyle, medical and biological data. Genetics research is already shaping better treatments. This exciting initiative is expected to start producing novel findings rapidly during this year and will make UK Biobank even more useful for health-related research.

UK Government and charity medical research funders have invested about 200 million in UK Biobank. The costs of gene sequencing are falling, but doing it on a large scale involves highly-specialised capabilities and is expensive with an estimated cost of $150 million if all 500,000 participants are sequenced. That is why academia and industry working together is so important. The initial investment by GSK and Regeneron will be a tremendous boost to the value of the UK Biobank resource for academic and industry researchers around the world, studying many different conditions.

The RGC has previously sequenced DNA samples from more than 150,000 individuals and is now sequencing at a rate exceeding 150,000 individuals per year. The centre has successfully applied large-scale human genetics to discover new drug targets and validate existing development programmes, and has collaborated with more than 35 institutions around the world.

GSK has significant expertise in genomics and is increasingly incorporating the almost daily advances in this scientific field into its drug research programmes. A dedicated team of scientists focus on identifying new opportunities for drug discovery based on genetically-validated drug targets, working across the Companys R&D organisation, and through major external collaborations. GSKs Open Targets collaboration with the European Bioinformatics Institute, the Wellcome Trust Sanger Institute and Biogen includes an open access research platform, which makes genetic and biological data openly available to support drug discovery. Over 60% of the targets selected for new GSK drug discovery programmes in 2016 are supported by human genetic evidence.

Comment from Patrick Vallance, President, R&D at GSK:

I believe that we are in a new era of drug discovery because of a fundamental change in our understanding of human biology, driven largely by advances in human genetics. UK Biobank is one of the most important health resources available to scientists today, offering a rich source of information about health and disease.

Having been actively involved in UK Biobank as a board member since 2013, Im delighted that, through our collaboration with Regeneron, we can enrich this resource for the wider scientific community and also provide potential new opportunities for companies such as ours to develop new medicines for patients.

It demonstrates how important the UK is as a centre for innovative research. GSK is committed to ensuring that the UK continues to be an environment that fosters collaboration and supports end-to-end scientific progress, ranging from cutting-edge genomics to the rapid uptake of new approaches and medicines by the NHS, which can ultimately benefit patients.

Comment from George D Yancopoulos, MD, PhD, President and Chief Scientific Officer of Regeneron:

Our large-scale sequencing and analysis capabilities, coupled with UK Biobanks vast trove of de-identified biological and medical information, pose tremendous opportunities for clinically meaningful discoveries that can make a difference for patients. We have long-recognised that advancing the pace and clinical utility of human genetics research requires collaboration and an open exchange of data between industry, academia and public health groups, and we are pleased to expand upon our existing foundational research collaborations through this effort with the UK Biobank and GSK. For Regeneron, we believe this initiative will greatly enhance our existing efforts in gene discovery and genetics-guided drug development.

Excerpt from:
GSK & Regeneron Announce Big Gene Sequencing Initiative - Drug Discovery & Development

Posted in Human Genetics | Comments Off on GSK & Regeneron Announce Big Gene Sequencing Initiative – Drug Discovery & Development

How long should the state keep your DNA? – Indianapolis Star

Posted: at 1:25 pm

UIndys molecular anthropology laboratory conducted the research.(Photo: Photo provided by the University of Indianapolis)

If an individual is arrested, and DNA is collected but prosecutors do not immediately file charges how long should the government be able to hold on to the DNA sample?

Is 30 days enough time? What about six months?

Or should the government be allowed to keep a person's DNA for a year, even if he or she has not been formally charged with a crime?

Lawmakers on Wednesday debated the question during a committee hearing for a bill that would allow police to take a DNA sample upon arrest, broadening the scope of the state's DNA database, which currently only takes samples from those who have been convicted of a crime.

Ben Davis killing:DNA, cellphone link man to student's death

DNA tests:Muncie man walks free after rape conviction set aside

First love:After wife's death 'Butler helped my fill that void'

Versions of the bill have passed both the House and the Senate, signaling support for the measure, which proponents say will help police solve crimes and could exonerate innocent people. But the proposal has also generated vigorous debate about privacy rights and the potential for government overreach.

Now, the bills are back in committee hearings as lawmakers hash out details about how the measure would actually work, if enacted.

During the Senate Judiciary Committee hearing, testimony centered on two questions:

Lawmakers agree that people should be able to remove the DNA sample from the system if they are arrested and never charged, but the time frame is up for debate.

In the version ofHouse Bill 1577that passed the Indiana House of Representatives, a person could remove a DNA sample from the system if no charge was filed within 30 days. But as lawmakers are working to align that bill with the similarSenate Bill 322, which passed the Senate, they altered the provision so that prosecutors now have a full year to file charges before an individual can remove a DNA sample from the system.

"When someone is arrested on a felony warrant, it may take some time to get charges filed," said Chris Naylor, assistant executive director of the Indiana Prosecuting Attorneys Council, adding that 30 days may be too short for more complex cases.

But the provision received pushback from some lawmakers, who saw it as a violation of privacy for someone who is not charged with a crime.

"If I was a prosecutor I could overcharge everybody because I would get everyones DNA," said Sen. Michael Young, ranking member of the Senate Judiciary Committee.

Larry Landis, executive director of the Indiana Public Defender Council,offered something of a compromise, suggesting that people should be able to remove a DNA sample if no charges are filed within 185 days.

"If a prosecutor hasn't decided after 185 days, it likely never will be filed," Landis said.

Rep. Greg Steuerwald, who authored the House version of the bill, pointed out that the bill has been amended to contain safeguards to protect innocent people. The House adopted an amendment that says a judge must find probable cause for an arrest before a DNA sample can be entered into the system.

The bills also say that a DNA sample can be removed if an individual is acquitted, if charges are dismissed and if a felony charge is bumped down to a misdemeanor.

Lawmakers also debated about who should be responsible for removing the DNA sample, if an arrest doesn't lead to a conviction. As the bills read now, the person arrested must submit the request for approval by prosecutors.Steuerwald noted that the arrestee has the greatest incentive to pursue this. Under the bill, police must offer information about the removal process upon taking the sample.

But some committee members suggested the state should bear the responsibility, so as not to put undue burden on someone who may have been wrongfully accused, particularly if the individual is indigent.

"For me, putting the burden on an innocent person, I don't see a public policy reason to do that," Sen. Greg Taylor said.

The issue gained traction last year whenDNA from an Ohiodatabasethat includes arrestees helped solve boththeslaying of an elderly Zionsville manin November andattacks on two Indianapolis police stations.

Upon a felony arrest, a person's DNA sample would be submitted to databases that would allow police across the country to compare it to DNA collected at crime scenes.

Call Star reporter Madeline Buckley at (317) 444-6083. Follow her on Twitter:@Mabuckley88.

Should police take a DNA sample when making arrests?

Read or Share this story: http://indy.st/2mQsdc0

Read the rest here:
How long should the state keep your DNA? - Indianapolis Star

Posted in DNA | Comments Off on How long should the state keep your DNA? – Indianapolis Star

A New Kind of DNA Evidence – JSTOR Daily

Posted: at 1:25 pm

It was a high-profile crime in New York Citya jogger was murdered while running in a local park, anddetectives had few leads. As the months passed and the crime remained unsolved, the victims family began pushing for wider use of familial DNA, or searching DNA databases for partial matches to DNA evidence that might represent a family member of the killer (the technique has been successfully used). Detectives eventually identified a suspect without it, but the idea of familial DNA testing is not going away.

But how does it work? After amplification and controls against contamination, linking a DNA sample to an individual depends on Short Tandem Repeats, or STRs. STRs are very short segments of DNA, only a few base pairs long ( base pairs are pairs of nucleotides making up each strand of the double stranded DNA molecule; there are 3 billion base pairs on the human genome). The number of times each STR repeats at a given loci (location on the genome) is highly variable between people. To ensure that STRs match a particular individual, the U.S. standard is to examine the STRs at 13 different loci plus a sex-linked gene called amelogenin. Since each individuals genome consists of a set of DNA from each of their parents, it is really 26 different STR loci being compared (13 times on different chromosomes). The probability of all 26 loci matching is as low as 1 in a trillion.

Familial DNA searches extend the potential privacy consequences to millions of more people.

Only a complete match can lead to a conviction, but since we share 50% of our DNA with siblings and parents, and lesser amounts with cousinsand other families members, a partial match might indicate a family member. How close a match is required to indicate a family member versus a match that occurs by chance? It depends on how rare the matching alleles are. If particularly rare variant is present, as few as 5/26 matching alleles may be sufficient; when only common alleles are present 15/26 matches are required to establish a family relationship. Investigators need to obtain DNA from specific family members to establish a direct match with a crime scene sample.

DNA is collected and archived all over the country. Many states only keep samples from those who are convicted, but some states keep samples simply upon arrest, or even from witnesses and other voluntary submissions. The databases contain millions of people, and familial searches extend the potential privacy consequences to millions more, most of whom are unconnected to a crime. Expanding the use of these tools also threatens to further ensnare groups that are already over-represented in the criminal justice system. Each state has its own policy about familial DNA searches, and there are no national familial searches, which causes some confusion. The trick is to balance these concerns against the benefit to society of identifying dangerous criminals.

By: Melissa Lee Phillips

BioScience, Vol. 58, No. 6 (June 2008), pp. 484-489

Oxford University Press on behalf of the American Institute of Biological Sciences

By: David R. Paoletti, Travis E. Doom, Michael L. Raymer and Dan E. Krane

Jurimetrics, Vol. 46, No. 2 (WINTER 2006), pp. 161-175

American Bar Association

Comments are closed.

Read more:
A New Kind of DNA Evidence - JSTOR Daily

Posted in DNA | Comments Off on A New Kind of DNA Evidence – JSTOR Daily

Wolf or dog? DNA means difference between life and death for beloved Colo. pet. – Washington Post

Posted: at 1:25 pm

In late February, a dog named Capone escaped from his yardin the city of Aurora, Colo. It was the only time in seven years living on the property, his owners said, that their fence could not contain Capone. The animal, a rescue dog his owners believed to be aGerman shepherd with black Labrador mixed in, made his way toward a nearby residents home.

He failed to charm the neighbors. There was an aggressive dog in my backyard and he tried attacking us when we tried to get him off our lawn, Diana MontoyatoldCBS 4. He would just run to us and try to jump us.

Aurora Animal Control captured Capone and held him at the local shelter. Animal controlgrew suspicious that Capone was not a typical dog there was something wolfish about Capones character, behavior and body, they determined.

The responding officer assessed the dog, which had been at the (neighbors) residence for five hours, and noted continued aggressive behavior, including approaching with bared teeth, low growling, hard stare and lowered head, Aurora officials told the Aurora Sentinel in a statement.

From the outset, Tracy Abbato, Capones owner, disputed that her dog was part wolf. She alsodenied he was athreat.

Hes not aggressive. Capone is a very mellow, laid back dog, she said to Timemagazine on March 16. Hes a typical dog. Hes a family member. He doesnt bother anybody. Had Capone turned out to be part wolf, it was possible that animal control would have had him euthanized.

After catching the escapee, Aurora officials declined to release Capone to his family. They demanded that Abbato and her family wait until a genetic testcould determine that Capone was not part wolf.

A DNA test later vindicated Abbatos assertion that Capone was not a wolf. The results came back negative, she told Denver7.Not an ounce of wolf. On Wednesday, the Aurora Municipal Court cleared Capone to return home.

It marked the close of a nearlymonth-long separation.Its hard waking up and hes not there, Abbato said to CBS 4 on March 15. Its been heartbreaking. Hes our family member and we dont have him here with us.

A cityordinancebans animals or livestock that are wild, exotic or dangerous, which includes the unusual suspects would-be owners of gorillas and crocodiles are out of luck in Aurora. Coyotes, foxes and wolves are banned, too. As are wolf-dog hybrids. Dogs are allowed, although pit bulls and certain restrictedbreeds were outlawed in 2006.

The city is wary of dangerous dogs. Its not just a wolf-hybrid issue by itself, Michael Bryant, a city of Aurora spokesman, told Time. The 11-year-old dog bit a person on his familys property in the past. Aaron Acker, an attorney for the dogs owners, describedthe incident as Capone protecting against an intruder,Fox 32reported.

Capones owners were charged with several offenses: keeping a wild anddangerous animal, not having a license for Capone, not vaccinating the dog against rabies and allowing the dog to roam unrestrained.

Republicans in Colorados state senate took up Capones case. Big government is at it again,reada post on the senators website.An Aurora family is in danger of being split up because a local animal shelter suspects their family dog, Capone, could be distantly related to wolves. More than 600 people signedthe state Republican petition to spare Capone.

I felt we should speak up for an animal who cant speak for himself, Tim Neville, a Republican state senator, told the Colorado Statesman. We wanted to put attention on what appears to be local government overstepping and separating a pet away from its loving family and placing unnecessary charges against them.

Those concerned about wolf-dog pet ownershipcite the animals large size, high levels of energy and their unpredictability. A1993 incident involving a wolf-dog who, although vaccinated, reportedly contracted rabiesalsoraised questions about whether vaccines were as effective in hybrid animals.

A few hundred thousand wolf-dog hybrids are thought to live in the United States, although many wolf-dogs advertised as such are mislabeled dogs.

Wolf-dog behavior may be hard to generalize, said Kim Miles, a member of the wolf-dog advocacy group now known as the National Lupine Association,if the generational distance between wolf and dog is unknown.

Wolf-dogs arent easily pegged because theyre essentially a combination of wild and domesticated animals, Miles said to the Bark.A dog is like a 12-year-old child, and a wolf is like a 35-year-old man. The dog will generally do what you want it to, but the wolf will do what you want only if he wants to do it himself.

The animals can be difficult to keep as pets, too, because several states and municipalities outlaw thehybrids. (In D.C., for instance, it is illegal to own wolf-dog hybrids, cat-ocelot hybrids and other exotic pets. Whether exotic should be defined to include backyard chickens was amatter of recent debate.)

Although wolves and dogs are closely related, specific genetic differences may exist between wolves and their domesticated cousins. One test performed at theveterinarygenetics lab at the University of California at Davis, for instance, checks for some two dozen shortDNAmarkersthat are unique to wolves. Such an analysis may be able to tell whether a dog had wolfgreat-grandparents, although tracing any wolfish lineage to older generations is difficult.

The University of California at Davis test, conducted with a sample of Capones blood, seemed to sufficiently absolve the dogof any recent wild ancestry. We got some good news last night, Abbato said Sunday toFox 31. Capone is not wolf at all. He doesnt have an ounce of wolf in him.

The Aurora Sentinel reportedthat Serrano pleaded guilty to three of five charges failing to inoculate Capone against rabies, allowinghim to roam free and not registering Capone with the city. After a hearing at the Aurora Municipal Court, Capone was able to return home as of Wednesday afternoon.

We believe this resolution strikes a balance between keeping the family and their longtime pet together, and addressing the safety of the community as a whole, Aurora Animal Services manager Jenee Shipmantold the Aurora Sentinel in a statement.

The dog will return homevaccinated. And, as part of the resolution, Capones owners have agreed to construct a taller fence around their property.

More from Morning Mix

The stray dogs smile made him famous. Now, police say he looks too dangerous to stay in his new home.

Jack, Britains oldest dog, killed in savage terrier attack

A starving wolf stalked a woman and her dog for 12 hours. Then along came a bear.

See the rest here:
Wolf or dog? DNA means difference between life and death for beloved Colo. pet. - Washington Post

Posted in DNA | Comments Off on Wolf or dog? DNA means difference between life and death for beloved Colo. pet. – Washington Post

UK grants 1st license to make babies using DNA from 3 people … – KRON4.com

Posted: at 1:25 pm

Related Coverage

LONDON (AP) Britains Newcastle University says its scientists have received a license to create babies using DNA from three people to prevent women from passing on potentially fatal genetic diseases to their children the first time such approval has been granted.

The license was granted Thursday by the countrys fertility regulator, according to the university.

In December, British officials approved the cautious use of the techniques, which aim to fix problems linked to mitochondria, the energy-producing structures outside a cells nucleus. Faulty mitochondria can result in conditions including muscular dystrophy and major organ failure.

Mitochondria diseases can be devastating for families affected and this is a momentous day for patients, said Doug Turnbull, director of the research at Newcastle University. The university has said it is aiming to treat up to 25 patients a year.

To help women with mitochondria problems from passing them on to their children, scientists remove the nucleus DNA from the egg of a prospective mother and insert it into a donor egg from which the donor DNA has been removed. This can happen before or after fertilization. The resulting embryo ends up with nucleus DNA from its parents but mitochondrial DNA from a donor. The DNA from the donor amounts to less than 1 percent of the resulting embryos genes.

The license granted to Newcastle University relates only to the clinics capacity to perform the techniques, Britains fertility regulator said. The clinic must apply for each individual patient to be treated and no patient application has yet been approved.

Last year, U.S.-based doctors announced they had created the worlds first baby using such techniques, after traveling to Mexico to perform the procedure, which has not been approved in the United States.

Critics have raised concerns about the treatment, saying it will put people at unnecessary risk of an untested procedure. Some say women with faulty mitochondria should choose simply to use egg donors and that using the new techniques will open the door to genetically modified designer babies.

Go here to see the original:
UK grants 1st license to make babies using DNA from 3 people ... - KRON4.com

Posted in DNA | Comments Off on UK grants 1st license to make babies using DNA from 3 people … – KRON4.com

Idaho man who didn’t match victim’s DNA free after 20 years – Press Herald

Posted: at 1:25 pm

BOISE, Idaho An Idaho man who experts say was coerced into a false murder confession was freed Wednesday after spending half of his life behind bars.

A judge released Christopher Tapp after vacating his rape conviction and resentencing him to time served for the 1996 killing of Angie Dodd.

The release came after years of work by Tapps attorney, public defender John Thomas, and advocates, including Judges for Justice, the Idaho Innocence Project and the victims mother, Carol Dodge.

Angie Dodge was 18 and living in an Idaho Falls apartment on June 13, 1996, when she was sexually assaulted and killed at her home.

Tapp was a 20-year-old high school dropout at the time. He was interrogated for hours and subjected to multiple lie detector tests by police before confessing, but DNA evidence taken from the scene didnt match Tapp or any of other suspects in the case.

The release doesnt exonerate Tapp his murder conviction still stands under the plea agreement that transformed his 30-years-to-life sentence to time served. But the agreement allowed Tapp to leave the courtroom as a free man after 20 years in prison. He otherwise wouldnt have been able to seek parole until 2027.

Chris Tapp is innocent, his attorney, Thomas, said. Still, Thomas said, the plea deal was the right decision because it came with the certainty of freedom.

In court Wednesday, Carol Dodge said she was overwhelmed and felt great sadness that Tapp had lost 20 years of his life to prison.

The Idaho Falls Police Department announced Wednesday that it has a sketch of a suspect, but didnt release it.

Most of the recent developments in the case have focused on DNA at the scene.

Dodges body was found by co-workers. She had been raped and stabbed. Investigators were able to obtain DNA at the scene.

The initial investigation spanned months, and by the start of 1997, detectives began to suspect that Benjamin Hobbs and Tapp may have been involved. Hobbs was arrested in Ely, Nevada, in connection with a rape and accused of using a knife during the crime. Tapp, who was friends with Hobbs, was arrested in January and questioned about Hobbs suspected involvement in Dodges killing.

Over the next few weeks, Tapp was interrogated nine times and subjected to seven polygraph tests. At various times, police suggested he could face the death penalty, told him that he was failing the lie detector tests, suggested he may have repressed memories of the killing and offered him immunity if he implicated Hobbs and another suspect. He eventually confessed to being involved in the death.

But none of the DNA matched any suspect..

Under the deal, Tapp cant continue efforts to get his conviction overturned and must pay into Idahos victim compensation fund.

Go here to see the original:
Idaho man who didn't match victim's DNA free after 20 years - Press Herald

Posted in DNA | Comments Off on Idaho man who didn’t match victim’s DNA free after 20 years – Press Herald

Dramatic evolution within human genome may have been caused by malaria parasite – Science Magazine

Posted: at 1:24 pm

The mosquito-borne parasite Plasmodium vivax might have sparked the strongest evolutionary response in humans yet known.

smuay/iStockphoto

By Michael PriceMar. 23, 2017 , 8:00 AM

A genetic mutation that protects people from a common form of malaria spread like wildfire in sub-Saharan Africa about 42,000 years ago, according to a new study. Today, its nearly impossible to find somebody from this region who doesnt have it. That makes the mutation one of the swiftest, strongest changes to the human genome yet seenthough it remains a mystery why this particular disease sparked such a dramatic evolutionary response.

The worlds most widespread type of human malaria is caused by Plasmodium vivax, a single-celled parasite transmitted by mosquitoes. Although less deadly than other strains, P. vivax malaria remains a disruptive disease: It infected some 16 million people across the globe in 2013. Yet across much of sub-Saharan Africa, P. vivax accounts for fewer than 5% of all reported malaria cases. Thats because about 99% of Africans living here have a variant of a gene called DARC, which shuts off a particular protein receptor on the surface of red blood cells that the parasite needs to gain entry.

To learn more about how and when this mutation spread, Omar Cornejo, a population geneticist at Washington State University in Pullman, and colleagues analyzed full genome sequences from 1000 modern individuals from 21 population centers in Africa, Asia, and Europe. The researchers then employed a computer-based simulation that predicts how certain genetic variants spread throughout a population over time given the regions known demographics and various selective pressures.

Based on rates of genetic change, the simulation suggests the most recent common ancestor of living Africans who possessed the DARC mutation lived about 42,000 years ago, the team reports this month in PLOS Genetics. Back then, the mutation was likely just a random genetic variant possessed by a handful of people, not a functional evolutionary defense. Then something changedquite possibly the arrival of P. vivaxand some 8000 years later, more than 99% of people in the region had the mutation, according to the simulation.

Cornejo estimates that on average during that 8000-year period, for every 100 people born without the mutation, an additional 105 would have been born with it. Assuming that widespread exposure to P. vivax meant that people who had the mutation were more likely to survive than those without itthat would make this the strongest evolutionary response yet seen in the human genome, the researchers say.

Thats a bit mysterious because the disease caused by P. vixax is much less deadly than that caused by other Plasmodium strains, says David Serre, a microbiologist at the University of Marylands Institute for Genome Science in Baltimore who wasnt involved with this work. You get sick, you stay in bed for a few weeks, and most of the time you get better. One wouldnt expect such a powerful evolutionary response to a relatively benign disease, he notes.

One possibility is that the disease was much deadlier thousands of years ago, and that further adaptations in our immune system have rendered it less threatening, Serre says. Another is that evolution was acting against an entirely different, as-yet-unknown disease that used the same technique as P. vivax to enter red blood cells. The data are really good, the analysis is really good, but the story just doesnt quite make sense yet, he says.

Cornejo admits its a perplexing finding, and he agrees a heretofore unknown disease theoretically could be responsible.

Either way, he says the study should serve as a warning. Just as humans in Africa evolved to combat the parasite, the disease continues to evolve as well. Recent cases of P. vivax malaria have been reported in Madagascar, Ethiopia, and Sudan in people who possess the protective DARC mutation. Its not yet clear whether some other factor made them susceptible to the disease, or whether the parasite evolved to find another way into red blood cells. If its the latter, says Cornejo, millions of people who once didnt need to worry about P. vivax malaria might soon be at risk.

Please note that, in an effort to combat spam, comments with hyperlinks will not be published.

Read the original post:
Dramatic evolution within human genome may have been caused by malaria parasite - Science Magazine

Posted in Genome | Comments Off on Dramatic evolution within human genome may have been caused by malaria parasite – Science Magazine

Your Genome Holds the Key to a Healthier Life … if Machine Learning has its Way – Huffington Post

Posted: at 1:24 pm

Its a boy! or Its a girl! are pretty common pieces of information people expect to gather in a doctors office before their child is born. But what if in the near future those exclamations were followed by information that could impact that unborn childs lifelong health?

Genomic testing is ushering in that reality, revealing which gene-based issues could arise over a persons lifetime. This information could follow the soon-to-be newborn through his or her life, determining preventative care measures, identifying effective therapies and shaping their health all the way through to end-of-life care.

This technology is changing fast. As of right now, according to biotech analyst Jonathan Grobert, Less than 3 percent of the population knows anything about their genomic data. This opportunity is where the internet was in the 1970s. The Human Genome Project sequenced nearly all of the human genome by 2003, but this effort took 13 years and $1 billion to complete. By 2007, that effort had sped up 70 fold, and it now costs $1,500 and can be completed in about 15 minutes. Soon, according to Dr. Brendan Frey, getting a human genome sequenced will cost less than a trip to the grocery store.

Frey is the CEO of Deep Genomics, a company looking to improve the interpretation not just of genotype a persons genetic constitution but of phenotypes, which range from whether or not you're a redhead to whether or not you have cancer. His company wants to bridge this gap so doctors and patients can interpret and act on genetic information, despite the complex relationship between a persons genes and their phenotype, including health.

Theres a huge growth in data sets that allow us to literally peer inside of cells and measure at the single-molecule level what is happening in those cells, he says. So theres this explosion of data that connects genetics to the phenotypes. The best technology we have for making sense of large data sets is machine learning.

By applying machine learning to these large data sets, the genomics industry could change the current paradigm of medicine, which is hypothesis driven and tests for only a small number of pathologies while ignoring many others. Frey explains that switching to an information-based model could cut down on unnecessary invasive procedures, since it could do a better job at ruling out false positives.

For example, many women get mammograms. However, the efficacy of getting annual checkups for breast cancer has caused an unintended consequence. The odds a woman has a false positive after 10 years of annual mammograms is as high as 50 to 60 percent, according to the Susan G. Komen Foundation. Through an informatics-based approach, genomic machine learning could better determine which women actually need frequent imaging. Machine learning could parse through a large amount of relevant data to slice down that false positive rate.

An information science-based approach that leverages genotype information could also cut down on prescription rates for drugs. Instead of crudely prescribing the same drug to the masses, genomics could instead drive a precision medicine approach, where doctors understand which patients would most benefit from a drug before writing a script.

In spite of any hurdles, genomics is continuing to get cheaper, quicker and more accessible even outpacing Moores Law. Nine of the 10 leading causes of death, like Alzheimers, cancer and strokes, have a genetic factor. Linking this genome information with environmental factors and integrating across the board into the medical field is a big data problem. And its one machine learning is equipped to answer, says Frey.

When it comes to the health care industry, there are practices that will need to change to make that happen. I think the pressures are there, and the right forces are there to push the community and the industry in the right direction.

With this rapid pace of innovation in an increasingly crowded market, genomics companies must carve out their niche and differentiate against competitors with a messaging and positioning that sets them apart. In this rapid race for industry mindshare, genomics companies have a once-in-a-lifetime opportunity to make their mark. It makes for an exciting time for genomics companies to step out and become a thought leader in the field, contributing to the industry dialogue and shaping the market for generations to come.

Follow Alisa Valudes Whyte on Twitter: http://www.twitter.com/MerrittGroup

The rest is here:
Your Genome Holds the Key to a Healthier Life ... if Machine Learning has its Way - Huffington Post

Posted in Genome | Comments Off on Your Genome Holds the Key to a Healthier Life … if Machine Learning has its Way – Huffington Post

Page 1,950«..1020..1,9491,9501,9511,952..1,9601,970..»