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Category Archives: Transhuman News

Blue Origin Just Released Images of Its Sleek Space Tourism Capsule – Futurism

Posted: April 2, 2017 at 7:29 am

In Brief Blue Origin, the space company founded by Jeff Bezos, recently revealed the interior of its New Shepard space capsule. The company plans to send tourists into space aboard this suborbital space capsule by 2018. Ticket To Ride

While SpaceX just successfully launched a reused rocket for the first time Thursday,Blue Originhas done it before. Jeff Bezos private space company has reused one of its rockets twice, in fact. Just this week, the West Texas-based space tourism company gave a preview of its reusable space capsule.TheNew Shepard passenger capsule and rocket, according to Blue Origin, will be the companys tour bus for brief trips into space.

The sneak peek images from Blue Origin show the interior of the New Shepard, which boasts the the largest windows ever in space as Blue Origin described them. The seats showcase a sleek black design embossed with the companys feather logo. During take off, the seats are tilted back so its six passengers are facing up. Once in space, passengers can experience weightlessnessin the roomy cabin.

The New Shepard is scheduled for human test flights by this year, according to Blue Origin. Itsexpected to carry out its first consumer flights by 2018. Our New Shepard flight-test program is focused on demonstrating the performance and robustness of the system, Bezos said in a mass email update sent to their websites subscribers.In parallel, weve been designing the capsule interior with an eye toward precision engineering, safety and comfort.

While SpaceX and Blue Origin may be competing for who could launch the first fully reusable rocket, the goals of the two space companies differ slightly. For SpaceX, the ultimate goal is to bring humanity to Mars by the 2030s, with an immediate goal of sending two private individuals around the moon. Blue Origin, on the other hand, is developing their rockets for space tourism.

In fact, the New Shepard isnt meant for spaceflights beyond the Earths orbit. It is capable of suborbital flight that would bring it high enough to see space, but not high enough to completely loop around the Earth. The New Shepard also presents an opportunity for further microgravity research by serving as a laboratory in space, the company said. Bezos wants to offer higher altitude flights to space tourists eventually, using an orbital rocket now in production called New Glenn.

Space tourism is an exciting new frontier, and Blue Origin isnt the only companyworking toward it. Other companies include Virgin Galactic, which has been testing its own spaceplane VSS Unity for a glided space tour. Recently, the company has also started selling tickets for a trip aboard one of its spaceplanes. It has also received an FAA license for its SpaceShipTwo. Another company called World View is even using high-altitude balloons to bring tourists to space.

For now, space tourism plans are limited toa trip around the world and themoon. But eventuallyas NASAs space tourism posters show we may be able to book a ticket for a ride into the far reaches of space.

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Brain Implants Have Allowed a Quadriplegic Man to Move His Arm – Futurism

Posted: at 7:29 am

In BriefA man with quadriplegia was able to use a system combining abrain-computer interface (BCI) and Functional ElectricalStimulation (FES) technology to move his arms again just bythinking. Movement Lost and Found

Eight years ago, Bill Kochevar was paralyzed in a cycling accident. Since then, he hasnt been able to move anything below his shoulders until now.

As part of a trial at Case Western Reserve University,two tiny, 96-channel electrodes were implanted in the motor cortex of Kochevars brain. Essentially, the electrodes register the actions of his neurons and respond by signaling a device that stimulates his arm muscles. The system has given him the ability to grasp and lift things the same way he used to, by simply thinking the command to his body. He can now drink through a straw after raising a mug of water to his mouth and eat mashed potatoes with a fork.

Kochevar prepared for the trials by learning how to move a virtual reality (VR) arm on a computer using his mind. He practiced this for four months, after which 36 electrodes were surgically implanted into his right arm. The electrodes were strategically placed to control the movement of his upper and lower arm, elbow, hand, shoulder, and wrist.

Now, when Kochevar thinks about moving his arm, the brain signals travel to the brain-computer interface (BCI), which decodesand translates them into commands for intended movements. Those commands are then converted again into patterns of electrical pulses by the Functional Electrical Stimulation (FES) system in his arm. The pulses stimulate the electrodes, which move the muscles.

This successful trial, which wasthe first of its kind in the world, was part of the BrainGate2 study, which is researching the feasibility and safety of using BCI systems to help paralyzed people.

The research team says that advances needed to use the technology outside of a lab setting are not far from reality.

The brain implant would need to be wireless, but work on that is already underway. The movements themselves would also need to be more precise. That will be achieved once the investigators improve the stimulation and decoding patterns. FES systems that are entirely implantable are already being tested in other clinical research, as well.

Every day, most of us take for granted that when we will to move, we can move any part of our body with precision and control in multiple directions, and those with traumatic spinal cord injury or any other form of paralysis cannot, Case Western Reserve School of Medicine associate professor of neurology Benjamin Waltertold The Daily Case. By restoring the communication of the will to move from the brain directly to the body, this work will hopefully begin to restore the hope of millions of paralyzed individuals that someday they will be able to move freely again.

For somebody whos been injured eight years and couldnt move, being able to move just that little bit is awesome to me, said Kochevar. Its better than I thought it would be.

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Elon Musk’s revolt against futurist-led A.I. Apocalypse – TRUNEWS

Posted: at 7:28 am

March 27, 2017

On Sunday Vanity Fair published a detailed summary of SpaceX CEO Elon Musks reservations against Artificial Intelligence

(VERO BEACH, FLA) In the 7,900 word manifesto titled Elon Musks Billion-Dollar Crusade to Stop the A.I. Apocalypse Vanity Fairs Maureen Dowd interviewed the leading figures of Silicon Valley, including Demis Hassabis, Peter Thiel, and Sam Altman, to decipher why fellow futurist Elon Musk is no fan of his colleagues goal of ubiquitously connected robotic artificial intelligence.

The full manuscript is available here, these are notable nuggets from the piece:

The way to escape human obsolescence, in the end, may be by having some sort of merger of biological intelligence and machine intelligence. Were already cyborgs. Your phone and your computer are extensions of you, but the interface is through finger movements or speech, which are very slow. For a meaningful partial-brain interface, I think were roughly four or five years away.

At the 2017 Mobile World Congress (MWC) in Barcelona, Spain, TRUNEWS host Rick Wiles was told by keynote speakers that the integration of computers into human beings is a goal being pursed by the same architects behind the implementation of an Artificially Intelligent (AI) ubiquitously connectedGlobal Brain.

On the March 16th and 17th editions of TRUNEWS, host Rick Wiles described what he was told about the development of a Global Brain and how the Christians today must learn to evangelize in this coming technocracy.

TRUNEWS copy, TRUNEWS analysis

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Under Armour upgrades its 3D-printed shoe with ArchiTech Futurist – Digital Trends

Posted: at 7:28 am

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Why it matters to you

3D-printed shoes are getting better with each model and the ArchiTech Futurist is part of a technological movement.

Year after year, 3D-printing technology is getting better. There are more products that can be printed andthe machines have been refined to the point that many printed objects dont look printed. Shoes are the latest endeavor across the biggest names in athletics and Under Armour released its latest model.

The ArchiTech Futurist is an updated version of the companys ArchiTech running shoe it released in 2016. This time, the technology is back in a high-top variant.With a 3D-printed midsole made from a lattice network, this shoe offers plenty of stability and cushion.

More:Awesome Tech You Cant Buy Yet: 3D printed violins, biometric wallets, and more

Those intertwined loops are what provide the shoe with its cushioning and support. Overtop that is a flat outsole that features different density foams for a smoother feel. What sets this shoe apart from last years model is how it fits. The Futurist uses a compression lace system with a neoprene shroud and a zipper. Just like a compression sleeve, it conforms to each users foot. This provides lockdown and support witha tailored and seamless fit.

Additionally, the shoe takes advantage of Under Armours SpeedForm. This upper maintains the seamless look and locks the heel into the shoe. Whether the user is lifting, training, or running, the shoe will maintain a seamless fit with the heel. This is a shoedesigned for superior fit and comfort with a modern silhouette.

Due to the complexity of the tendrils, each shoe takes a full day of printing. Just like the ArchiTech before it, the Futurist launched with a very limited release at a retail price of $300. While the shoe is currently sold out, those who are interested are encouraged to sign up for email notifications about availability.

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Can Futurists Predict the Year of the Singularity? – Singularity Hub

Posted: at 7:28 am

The end of the world as we know it is near. And thats a good thing, according to many of the futurists who are predicting the imminent arrival of whats been called the technological singularity.

The technological singularity is the idea that technological progress, particularly in artificial intelligence, will reach a tipping point to where machines are exponentially smarter than humans. It has been a hot topic of late.

Well-known futurist and Google engineer Ray Kurzweil (co-founder and chancellor of Singularity University) reiterated his bold prediction at Austins South by Southwest (SXSW) festival this month that machines will match human intelligence by 2029 (and has said previously the Singularity itself will occur by 2045). Thats two years before SoftBank CEO Masayoshi Sons prediction of 2047, made at the Mobile World Congress (MWC) earlier this year.

Author of the seminal book on the topic, The Singularity Is Near, Kurzweil said during the SXSW festival that whats actually happening is [machines] are powering all of us. Theyre making us smarter. They may not yet be inside our bodies, but by the 2030s, we will connect our neocortex, the part of our brain where we do our thinking, to the cloud.

That merger of man and machinesometimes referred to as transhumanismis the same concept that Tesla and SpaceX CEO Elon Musk talks about when discussing development of a neural lace. For Musk, however, an interface between the human brain and computers is vital to keep our species from becoming obsolete when the singularity hits.

Musk is also the driving force behind Open AI, a billion-dollar nonprofit dedicated to ensuring the development of artificial general intelligence (AGI) is beneficial to humanity. AGI is another term for human-level intelligence. What most people refer to as AI today is weak or narrow artificial intelligencea machine capable of thinking within a very narrow range of concepts or tasks.

Futurist Ben Goertzel, who among his many roles is chief scientist at financial prediction firm Aidyia Holdings and robotics company Hanson Robotics (and advisor to Singularity University), believes AGI is possible well within Kurzweils timeframe. The singularity is harder to predict, he says on his personal website, estimating the date anywhere between 2020 and 2100.

Note that we might achieve human-level AGI, radical health-span extension and other cool stuff well before a singularityespecially if we choose to throttle AGI development rate for a while in order to increase the odds of a beneficial singularity, he writes.

Meanwhile, billionaire Son of SoftBank, a multinational telecommunications and Internet firm based in Japan, predicts superintelligent robots will surpass humans in both number and brain power by 2047.

He is putting a lot of money toward making it happen. The investment arm of SoftBank, for instance, recently bankrolled $100 million in a startup called CloudMinds for cloud-connected robots, transplanting the brain from the machine to the cloud. Son is also creating the worlds biggest tech venture capitalist fund to the tune of $100 billion.

I truly believe its coming, thats why Im in a hurryto aggregate the cash, to invest, he was quoted as saying at the MWC.

Kurzweil, Son, Goertzel and others are just the latest generation of futurists who have observed that humanity is accelerating toward a new paradigm of existence, largely due to technological innovation.

There were some hints that philosophers as early as the 19th century, during the upheavals of the Industrial Revolution, recognized that the human race was a species fast-tracked for a different sort of reality. It wasnt until the 1950s, however, when the modern-day understanding of the singularity first took form.

Mathematician John von Neumann had noted that the ever-accelerating progress of technology gives the appearance of approaching some essential singularity in the history of the race beyond which human affairs, as we know them, could not continue.

In the 1960s, following his work with Alan Turing to decrypt Nazi communications, British mathematician I.J. Goode invoked the singularity without naming it as such.

He wrote, Let an ultra-intelligent machine be defined as a machine that can far surpass all the intellectual activities of any man however clever. Since the design of machines is one of these intellectual activities, an ultra-intelligent machine could design even better machines; there would then unquestionably be an intelligence explosion, and the intelligence of man would be left far behind.

Science fiction writer and retired mathematics and computer science professor Vernor Vinge is usually credited with coining the term technological singularity. His 1993 essay, The Coming Technological Singularity: How to Survive in the Post-Human Erapredicted the moment of technological transcendence would come within 30 years.

Vinge explains in his essay why he thinks the term singularityin cosmology, the event where space-time collapses and a black hole formsis apt: It is a point where our models must be discarded and a new reality rules. As we move closer and closer to this point, it will loom vaster and vaster over human affairs till the notion becomes commonplace. Yet when it finally happens it may still be a great surprise and a greater unknown.

But is predicting the singularity even possible?

A paper by Stuart Armstrong et al suggests such predictions are a best guess at most. A database compiled by the Machine Intelligence Research Institute (MIRI), a nonprofit dedicated to social issues related to AGI, found 257 AI predictions from the period 1950-2012 in the scientific literature. Of these, 95 contained predictions giving timelines for AI development.

The AI predictions in the database seem little better than random guesses, the authors write. For example, the researchers found that there is no evidence that expert predictions differ from those of non-experts. They also observed a strong pattern that showed most AI prognostications fell within a certain sweet spot15 to 25 years from the moment of prediction.

Others have cast doubt that the singularity is achievable in the time frames put forth by Kurzweil and Son.

Paul Allen, co-founder of Microsoft and Institute of Artificial Intelligence, among other ventures, has written that such a technological leap forward is still far in the future.

[I]f the singularity is to arrive by 2045, it will take unforeseeable and fundamentally unpredictable breakthroughs, and not because the Law of Accelerating Returns made it the inevitable result of a specific exponential rate of progress, he writes, referring to the concept that past rates of progress can predict future rates as well.

Futurist Nikola Danaylov, who manages the Singularity Weblog, says he believes a better question to ask is whether achieving the singularity is a good thing or a bad thing.

Is that going to help us grow extinct like the dinosaurs or is it going to help us spread through the universe like Carl Sagan dreamed of? he tells Singularity Hub. Right now, its very unclear to me personally.

Danaylov argues that the singularity orthodoxy of today largely ignores the societal upheavals already under way. The idea that technology will save us will not lift people out of poverty or extend human life if technological breakthroughs only benefit those with money, he says.

Im not convinced [the singularity is] going to happen in the way we think its going to happen, he says. Im sure were missing the major implications, the major considerations.

We have tremendous potential to make it a good thing, he adds.

Image Credit: Shutterstock

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Here Is NASA’s Plan for a Space Station That Orbits the Moon – Popular Mechanics

Posted: March 31, 2017 at 6:39 am

Behind the scenes, NASA and its international partners are putting the finishing touches on humanity's new home in space. This future science station, which will effectively replace the International Space Station when it reaches retirement age in the 2020s, will be a fraction of the size but carry astronauts hundreds of thousands of miles farther into space. In fact, it might travel farther away from our planet than any other human-piloted spacecraft, including the Apollo missions.

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But the most exciting idea behind this new station, destined to make its home orbiting near the moon (aka a cis-lunar orbit), is it will provide a new foothold for future human missions to Earth's closest celestial neighbors, like asteroids, the moon itself, and Mars. Because the station is in an egg-shaped orbit, stretching anywhere from 1,500 km to 70,000 km (930 to 44,000 miles) from the Moon, it would need only a little push to be sent flying to a yet-to-be-chosen destination.

NASA

NASA engineers and their colleagues from four other space agencies have been working on the design of the station for a few years. But without a green light from their political bosses, they had to keep any blueprints a secret. Popular Mechanics spoke with NASA sources and got a small peek at what's coming.

If everything goes as planned, the first mission will launch in 2023 and position a robotic spacecraft called the Power and Propulsion Bus (PPB) in a stretched orbit around the Moon. Then, in the next two years, a pair of barrel-shaped modulesfour-and-a-half meters wide and five meters long, and both weighing under 10 tons eachwill be delivered to the same orbit and bolted to the PPB.

Together, they'll house four astronauts up to 90 days at a time. In addition, a Russian-built airlock module will be added to the station in mid-2020s to make it much easier for the crew to walk outside of its space home.

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On the outside, both modules will be plastered with radiators doubling as micrometeoroid armor, with four docking ports to connect to each other and to receive visiting spacecraft. Fortunately, cis-lunar space is practically pristine compared to all the space junk in Earth orbit, allowing designers to consider thinner walls.

On the inside, everything will be meticulously designed to save mass and maximize room. The dining table will fold after each meal and the sleeping compartments might inflate and deflate as needed. The fridge will have to multitask as a kitchen appliance and scientific sample storage. Huge efforts will be made to recycle and reuse every drop of water, oxygen, and other consumable resources onboard.

The biggest challenge for the engineers designing the cis-lunar station is dealing with trash. Because space is limited and ejecting garbage wastes precious oxygen, engineers will need to compact trash as much as possible. Eventually, accumulated trash will be loaded into the cargo ship after its unloading.

Meanwhile, the means of getting to the space station itself is still up for debate. Each crew shift on the cis-lunar outpost will be accompanied by a dedicated supply ship, but NASA hasn't decided on the mode of transportation or its provider, whether public or private.

International Space Station

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The ultimate goal for this new ambitious project will be a deep-space expedition lasting more than a year, a dress rehearsal of sorts for a future mission to Mars. To make that possible, NASA will need to add a brand-new 20-ton spacecraft with better propulsion and bigger crew quarters in the second half of the 2020s.

In addition, the cis-lunar base might serve as a parking hub for the robotic (and later human) landers returning from the surface of the Moon. Along with NASA's new Orion spacecraft, the Russian next-generation spacecraft that's now in development might drop by for a visit as well. NASA sources also hint that the station will be able to accommodate an extra module, in case a "new partner" decides to come onboard most likely referring to China.

In any case, sometime in the second half of the 2020s the ISS will likely finish its 30-year tenure. A colossal splashdown in the remote part of the ocean will close a chapter in the history of human space flight but free up budgets for new horizons. By then, NASA and its partners hope to have a new outpost in the lunar orbit along with good ideas where to fly it next.

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Spacewalking astronauts lose a piece of shield needed for International Space Station – Los Angeles Times

Posted: at 6:39 am

Spacewalking astronauts lost an important piece of cloth shielding needed for the International Space Station on Thursday when it floated away.

Astronaut Peggy Whitson immediately reported the mishap to Mission Control, which tracked the bundle as it drifted off. NASA said it would be monitored to make sure it doesn't come back and hit the station.

The shielding protects against micrometeorite debris. It was one of four pieces that Whitson and Shane Kimbrough were installing over the spot left by a relocated docking port. NASA spokesman Dan Huot said the three remaining shields were installed to cover the most vulnerable spots.

It was a disappointing turn of events in a record-setting spacewalk for Whitson, the world's oldest and most experienced spacewoman. It was the eighth spacewalk of her career, the most performed by a woman. There was frustration in her voice as she informed Mission Control.

Huot said it was not immediately clear who let the shield go or how it got away; it's supposed to be tethered to the station or spacewalker at all times.

Spacewalkers have lost objects before, but usually the items are small, like bolts. In 2008, an astronaut lost her entire tool kit during a spacewalk.

Each fabric shield weighs 18 pounds. When unfolded, it is about 2 inches thick and measures about 5 feet by 2 feet, according to NASA. The entire 250-mile-high space station is protected, in some fashion, against possible debris strikes.

The docking port was disconnected during a spacewalk last Friday by Kimbrough, the space station's commander and a six-time spacewalker. Then flight controllers in Houston moved it to a new and better location Sunday. It will serve as one of two parking spots for commercial crew capsules under development by SpaceX and Boeing.

The spacewalkers hooked up vital heater cables to the docking port and removed a cover from the top. Then they turned to the shields, and that's when one of the folded coverings got away. Mission Control instructed the astronauts to retrieve the cloth cover just removed from the docking port, and try to fashion it over the gaping hole left by the lost shield.

Midway through Thursday's spacewalk, Whitson was set to surpass the current record for women of 50 hours and 40 minutes of total accumulated spacewalking time, held by former space station resident Sunita Williams. Williams is one of four NASA astronauts who will make the initial test flights of the SpaceX Crew Dragon and Boeing Starliner capsules. The first flight could occur as early as next year.

A Russian holds the all-time spacewalking record: Anatoly Solovyev with 16.

The 57-year-old Whitson has been in orbit since November. This is her third space station stint. Altogether, she's spent more than 500 days off the planet, also more than any woman.

She's scheduled to return to Earth in June but may stick around an extra three months, until September. NASA is hoping to take advantage of an extra seat in the Russian Soyuz spacecraft that's due to launch next month and return in September. A decision is expected soon.

NASA, meanwhile, has indefinitely delayed a spacewalk that had been scheduled for next week. A shipment with replacement parts needed for that spacewalk is on hold because of rocket concerns at Cape Canaveral, Fla. Shipper Orbital ATK is relying on the United Launch Alliance's Atlas V to haul up the goods.

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NASA assigns astronauts to future space station missions – Spaceflight Now

Posted: at 6:39 am

Astronauts Ricky Arnold (left) and Joe Acaba (right) aboard the space shuttle Discovery in March 2009. Credit: NASA

NASA has announced that veteran astronauts Joe Acaba and Ricky Arnold will launch on nearly six-month expeditions aboard the International Space Station starting in September and in March 2018, filling seats aboard Russian Soyuz spaceships recently acquired in a commercial arrangement with Boeing.

Acaba is set to launch first, riding to the space station inside the Soyuz MS-06 spacecraft from the Baikonur Cosmodrome in Kazakhstan in September with Russian commander Alexander Misurkin and NASA flight engineer Mark Vande Hei. That trio will be part of the stations Expedition 53 and 54 crews, returning to Earth next February.

The mission will be Acabas third spaceflight since his selection as a NASA astronaut in 2004. The California native first flew in space aboard the shuttle Discovery on the STS-119 mission in March 2009, then spent four months in orbit on the International Space Station in 2012. Acaba has logged nearly 138 days in space on his two previous flights.

It will be Vande Heis first space mission, and the second for Misurkin.

Russian cosmonaut Alexander Skvortsov, NASA astronaut Scott Tingle and Japanese flight engineer Norishige Kanai are set to launch on the next Soyuz flight no sooner than late December. Those crew members were already assigned to the mission.

Astronaut Ricky Arnold will join NASAs Drew Feustel and a Russian cosmonaut on a Soyuz launch in March 2018 as part of the stations Expedition 55 and 56 crews. Born in Maryland, Arnold previously flew in space as a crewmate of Acaba on Discoverys STS-119 mission, accumulating nearly 13 days in space.

Feustel, who was already training for his space station expedition, is a veteran of two space shuttle missions the shuttle Atlantis servicing mission to the Hubble Space Telescope in 2009 and the final flight of the shuttle Endeavour in 2011. Next years mission will be the first long-duration spaceflight for Arnold and Feustel.

Acaba and Arnold will fill seats that were planned to be empty. Russia has reduced the size of its crew complement on the space station until a new research lab is launched to the complex next year to cut down on costs, training and staffing requirements.

Using Boeing as an intermediary, the U.S. space agency opted to take advantage of empty Soyuz seats on two flights scheduled for launch from Kazakhstan in September and in March 2018.

Boeing received rights to the Soyuz seats from RSC Energia, prime contractor for Russias human spaceflight program, in a settlement reached last year to end three years of litigation stemming from payments related to the companies former partnership in the Sea Launch program.

NASA said astronaut Shannon Walker, veteran of a five-month stay on the space station in 2010, will train as a dedicated backup for Acaba.

Rookie astronauts Nick Hague and Serena Aun-Chancellor have also been assigned to space station missions, NASA said.

Hague, a colonel in the U.S. Air Force and a native of Kansas, will launch in September 2018 on a Soyuz ferry craft with two Russian cosmonauts for about a half-year rotation aboard the outpost. Aun-Chancellor, a flight surgeon from Fort Collins, Colorado, will launch on a Soyuz booster in November 2018 with Canadian flight engineer David Saint-Jacques and a Russian cosmonaut.

Aun-Chancellor is a member of NASAs 2009 astronaut class, and Hague was selected as an astronaut in 2013.

NASA has reserved options to fly three more of its astronauts to the space station on Soyuz spaceships in early 2019 if U.S. commercial crew spacecraft in development by Boeing and SpaceX are not ready in time.

Once the CST-100 Starliner and Crew Dragon commercial spaceships are declared operational, the space agency plans to fly most of its astronauts on U.S. vehicles, while continuing to launch at least one U.S. crew member on each Soyuz mission. Russia plans to have at least one of its cosmonauts on each CST-100 and Crew Dragon capsule in an in-kind arrangement that does not involve any exchange of funds.

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A Stem Cell Platform for Accelerating Genetic Disease Research – Technology Networks

Posted: at 6:38 am

These are neural stem cells in the adult mouse hippocampus. Green: the stem cells and their progeny express protein. Magenta: the hippocampal stem cells generate newborn neurons. Blue: mature granule neurons. Credit: Department of Biomedicine, University of Basel

Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. The work sheds light on how certain brain disorders develop, and provides a framework for developing and testing new therapeutics. Medications that appear promising when exposed to the new cells could be precisely tailored to individual patients based on their genetic background.

In the new study, published in The American Journal of Human Genetics, researchers used stem cells in their laboratory to simultaneously model different genetic scenarios that underlie neurologic disease. They identified individual and shared defects in the cells that could inform treatment efforts.

The researchers developed programmable stem cells, called induced pluripotent stem cells, from 12 children with various forms of Pelizaeus-Merzbacher Disease, or PMD. The rare but often fatal genetic disease can be caused by one of hundreds of mutations in a gene critical to the proper production of nerve cell insulation, or myelin. Some children with PMD have missing, partial, duplicate, or even triplicate copies of this gene, while others have only a small mutation. With so many potential causes, researchers have been in desperate need of a way to accurately and efficiently model genetic diseases like PMD in human cells.

By recapitulating multiple stages of the disease in their laboratory, the researchers established a broad platform for testing new therapeutics at the molecular and cellular level. They were also able to link defects in brain cell function to patient genetics.

Stem cell technology allowed us to grow cells that make myelin in the laboratory directly from individual PMD patients. By studying a wide spectrum of patients, we found that there are distinct patient subgroups. This suggests that individual PMD patients may require different clinical treatment approaches, said Paul Tesar, PhD, study lead, Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics, and Associate Professor of Genetics and Genome Sciences at Case Western Reserve University School of Medicine.

The researchers watched in real-time as the patients stem cells matured in the laboratory. We leveraged the ability to access patient-specific brain cells to understand why these cells are dysfunctional. We found that a subset of patients exhibited an overt dysfunction in certain cellular stress pathways, said Zachary Nevin, first author of the study and MD/PhD student at Case Western Reserve University School of Medicine. We used the cells to create a screening platform that can test medications for the ability to restore cell function and myelin. Encouragingly, we identified molecules that could reverse some of the deficits. The promising finding provides proof-of-concept that medications that mend a patients cells in the laboratory could be advanced to clinical testing in the future.

The stem cell platform could also help other researchers study and classify genetic diseases with varied causes, particularly other neurologic disorders. Said Tesar, Neurological conditions present a unique challenge, since the disease-causing cells are locked away in patients brains and inaccessible to study. With these new patient-derived stem cells, we can now model disease symptoms in the laboratory and begin to understand ways to reverse them.

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4 human genetics organizations that put ideology ahead of science – Genetic Literacy Project

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[Editors note: This is one partofa two-part series examining organizations that place ideology ahead of sciencewhen opposing advances in genetics.The companion piece on NGOs that misrepresent the science about food, farming and biotechnology can be found here.]

The science ofhuman geneticstouches our lives in a wide range of ways. We have expanded our knowledge ofhow the brain works, what race is (and isnt), how we can determine guilt or innocence in crimes,and even why we may behave the way we do. For some,including certain non-government organizations, this is scary stuff. Clearly, the human genetics arena is not as volatile as on the one comprising GMOs and agriculture. But here we look at several of these groups. Some of their concerns may be legitimate (genetic privacy and false results from forensic DNA tests, for example), but there are times when theyleave science behind when expressingconcerns about frighteningbut unlikelyscenarios.

GeneWatch UK is a nonprofit advocacy group,founded in 1998 and based in Buxton, England, that opposes the use of GMOs in agriculture. The group also opposes gene patents as well as the genetic modification and cloning of animals.

GeneWatch supportsgenetic modification only whenthere is no alternative to alleviate human (or animal) suffering. The organization also presumes that genetic engineering will lead tobiological weapons. The group also has raised concernsabout the storing of genetic information in databases and has pushed forregulations prohibitingdiscrimination by employers, insurers, police or others in official positions.

GeneWatch is skeptical that gene therapy or modification could lead to the development of personalized medicine or even treat the majority of diseases. It also believes that genetic testing does a poor job of identifying cures for diseases. According to GeneWatch:

Genes are poor predictors of common complex diseases in most people and targeting a minority of genetically susceptible individuals is usually a poor health strategy. The health impacts of smoking, poor diets, poverty and pollution are not limited to individuals with bad genes and require population-based preventive strategies (such as providing better sports facilities, healthier school meals and banning fast food ads to children).

While genetic testing and the development of precision medicine has had its uncertain starts and failures, many of these initial setbacks have been due to lack of sufficient data on specific genetic markers in disease, and not on a conceptual failure of the role of genetics in disease.

ETC Group (full name: Action Group on Erosion, Technology and Concentration) was renamed in 2001 from the former Rural Advancement Foundation International (RAFI), which traces its roots to the 1930s-era National Share Croppers Fund. RAFI was an advocate for farmers rights, opposing whattermed seed monopoly laws andgenetic modification in agriculture. RAFI changed its name to ETC Group to ensure non-profit status in the United States. The Canadian group is based inWinnipeg, Manitoba.

In the 1990s, itsfocus expanded from agricultureand GMOs to include human genetic issues, such as biopiracy,human genomics and nanotechnology. The group says it wasone of the first organizations to warn of the downside of genetic engineering of crops and livestock and has since kept an eye on developments in human biotech, synthetic biology, biowarfare and industrial biotech.

On synthetic biology, for example, ETC Group has called for stricter regulations, arguing: Synthetic biologists, engaged in a kind of extreme genetic engineering, hope to construct designer organisms that perform specific tasks such as producing biofuels or other high-value compounds. The group has even issued a comic book outlining these concerns, and arguesthat there is a lack of oversight of synthetic biology.

This is an oversimplification. The actual field is nowhere near the stage of creating monsters in the lab; instead, most synthetic biology consists of sequencing and assembling existing genes and oligonucleotide sequences for experimentation. If such genetic engineering efforts do indeed mix or edit existing genomes, regulations do exist to monitor these developments, beyond the Precautionary Principle recommendations under the Convention on Biological Diversity, the 1992 United Nations treaty that covers a variety of biological issues, including thegenetics use restrictions.

The Council for Responsible Genetics, based in Cambridge, Massachusetts, was founded in 1983. The organization says it reviews scientific data and analyzes where the information can influence policy.

One of the Councils major issues is genetic privacy. It has expressed concerns about a lack of adequate regulation to protect people with a genetic propensity toward disease. To organization worries that consumer genome companies like 23andMe can use individuals genetic sequences without regulatory oversight, and that DNA samples can be obtained, bought, sold and transferred with similar impunity.

These concernshavebeen met with some opposition from scientists, who useDNA sampleswhile researching genetic links todiseases, distribution of traits among and within certain populations, and to gain insights into how genes create and maintain us. However, therehave been mistakes and abuses arising from access to DNA. 23andMe, for example, had to stop selling genetic tests that predicted risks of disease at the request of the FDA, but resumed its consumer testing service with some modifications.

The organization also wantsstricterregulation of human cloning. The organization opposes human cloning and germ cell cloning, but supports cloning for stem cell research. After a 2014 paper was published that advanced the possibilities of human and germline cloning, Gruber told USA Today:

The science is no longer theoretical. We need to start putting laws into place to identify where the line should be drawn in terms of governance of these techniques.

The organization also has published a number of what it calls gene myths, demonstrating its skepticism of the value of genetics research in a number of areas, including population genetics, the genetics of race, the role of genes in mental disorders, published claims assert that genes exist for marital infidelity and for voting behavior, and that genetic tests can accurately predict childrens success in particular sports.

These are rather simplistic claims, since while genes, for example may not predict voting behavior, they can help us understand the evolution of certain behavioral traits (aggression, attraction for authority) that may have a genetic component.

The Center for Genetics and Society, based in Berkeley, California, was originally known as the Exploratory Initiative on the New Human Genetic Technologies before it was reorganized and renamed in 2001.Itwas created with the stated goalof alerting dozens of leaders of scientific, medical, womens health, environmental, human rights, social justice and other constituencies to the need for policies addressing the new human genetic technologies.

The organization supports genetic research that can result in improvements in health. According to CGS, biotech tools and practices have the power to promote or undermine individual well-being and public health, to create private fortunes or advance the public interest, and to foster or threaten a just and fair society.

Itwants a ban on any genetic technology that would fundamentally change the nature of the human speciesin other words, anything involving alteration of the germ line. These technologies include human cloning, particularly reproductive cloning, and mitochondrial DNA replacement therapy.

Other technologies of concern include in vitro fertilization (IVF), due to pre-implantation genetic diagnosis and commercial gestational surrogacy, which the group saysis conducted with little government regulation or oversight. CGS also is concerned about the use of chimeras or hybrid organisms for research, because of the question of legal or moral standing of a human-animal chimera.

Such concerns are moral based on arguments, with possible legal repercussions, but are not necessarily grounded in science.

Andrew Porterfieldis a writer, editor and communications consultant for academic institutions, companies and non-profits in the life sciences. He is based in Camarillo, California. Follow@AMPorterfieldon Twitter.

For more background on the Genetic Literacy Project, read GLP on Wikipedia.

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4 human genetics organizations that put ideology ahead of science - Genetic Literacy Project

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