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Category Archives: Transhuman News

Too Much Information? FDA Clears 23AndMe to Sell Home Genetic Tests for Alzheimer’s and Parkinson’s – Scientific American

Posted: April 7, 2017 at 8:32 pm

Genetic testing company 23AndMe is back with a controversial new offering, after the U.S. Food and Drug Administration on Thursday green-lighted the companys request to market a fresh batch of direct-to-consumer tests. Soon, with a simple saliva swab dropped in the mail, customers will be able to get answers about their genetic risk for developing 10 maladiesincluding Parkinsons disease and late-onset Alzheimers.

The FDA approval will likely reignite a long-simmering debate about when and how such tests should be used. Even when there are strong links between certain gene variants and medical conditions, genetic information often remains difficult to interpret. It must be balanced against other factors including health status, lifestyle and environmental influences, which could sharpen or weaken risk. If disease risk news is delivered at homewithout a genetic counselor or doctor on hand to offer contextmany geneticists fear it can lead to unnecessary stress, confusion and misunderstandings.

Against that backdrop, the FDAs decision came with caveats: Results obtained from the tests should not be used for diagnosis or to inform treatment decisions, the agency said in a statement. It added that false positive and false negative findings are possible.

But geneticist Michael Watson, executive director of the American College of Medical Genetics and Genomics, thinks consumers will have trouble making such distinctions and says he doubts people will view them as a mere novelty. Watson also worries 23AndMes wares may create other problems: Follow-up testing for some of these conditions may be quite pricey, he says, and insurance companies might not cover that cost if a person has no symptoms. He also notes that some of the conditions involved may have no proved treatments, leaving consumers with major concernsand few options to address them, aside from steps like making some lifestyle changes.

The makeup of 23AndMes reports to consumers is still being finalized, but the company says it does not expect to grade or rank a persons risk of developing any of the 10 conditions approved for analysis. Instead it will simply report a person has a gene variant associated with any of the maladies and is at an increased risk, the company told Scientific American.

The FDA decision may significantly widen the companys market and top off a years-long debate about what sort of genetic information should be available to consumers without professional medical oversight. After the FDAs 2013 decision to stop 23AndMe from sharing data about disease risk with its customers, the company was still able to offer them information about their genetic ancestry. It has also been selling consumer tests for genes that would indicate whether people are carriers for more than 30 heritable conditions, including cystic fibrosis and Tay-Sachs disease.

This month 23AndMe plans to release its first set of genetic health-risk reports for late-onset Alzheimers disease, Parkinsons disease, hereditary thrombophilia (a blood-clotting disorder), alpha 1-antitrypsin deficiency (a condition that raises the risk of lung and liver disease), and a new carrier status report for Gauchers disease (an organ and tissue disorder). Reports for other tests will follow, the company says.

In considering whether to approve the tests, the FDA says it reviewed studies that demonstrated the 23AndMe procedures correctly and consistently identified variants associated with the 10 conditions. Further data from peer-reviewed scientific literature demonstrated the links between these gene variants and conditions, and supported the underlying science.

The FDA also announced on Thursday that it plans to offer the company exemptions for similar genetic tests in the future, without requiring them to be submitted for premarket review. That decision could leave the door open to offering tests for other conditions that have questionable reproducibility, says Jim Evans, a genetics and medicine professor at the University of North Carolina School of Medicine.

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Scientists Say They’ve Identified a Gene Linked to Anorexia – Mental Floss

Posted: at 8:32 pm

People withanorexia nervosahave a distorted body image and severely restrict their food to the point of emaciation and sometimes death. It's long been treated as a psychological disorder, but that approach has had limited results; the condition has one of the highest mortality rates among psychiatric conditions. But recently, neuroscience researchers at the UC San Diego School of Medicine who study the genetic underpinnings of psychiatric disorders have identified a possible gene that appears to contribute to the onset of the disease, giving scientists a new tool in the effort to understand the molecular and cellular mechanisms of the illness.

The study, published in Translational Psychiatry, was led by UC San Diego's Alysson Muotri, a professor at theSchool of Medicines departments of pediatrics and cellular and molecular medicine and associate co-director of the UCSD Stem Cell Program. His team took skin cells known as fibroblasts from seven young women with anorexia nervosa who were receiving treatment at UCSDs outpatient Eating Disorders Treatment and Research Center, as well as from four healthy young women (the study's controls). Then the team initiated the cells to become induced pluripotent stem cells (iPSCs).

The technique, which won researcher Shinya Yamanaka the Nobel Prize in 2012, takes any nonreproductive cell in the body and reprograms it by activating genes on those cells. You can push the cells back into the development stage by capturing the entire genome in a pluripotent stem cell state, similar to embryonic stem cells, Muotri tells mental_floss. Like natural stem cells, iPSCs have the unique ability to develop into many different types of cells.

Once the fibroblasts were induced into stem cells, the team differentiated the stem cells to become neurons. This is the most effective way to study the genetics of any disorder without doing an invasive brain biopsy, according to Muotri. Also, studying animal brains for this kind of disorder wouldnt have been as effective. At the genetic level as well as the neural network, our brains are very different from any other animal. We dont see chimpanzees, for example, with anorexia nervosa. These are human-specific disorders, he says.

Once the iPSCs had become neurons, they began to form neural networks and communicate with one another in the dish similar to the way neurons work inside the brain. Basically what we have is an avatar of the patients brain in the lab, Muotri says.

His team then used genetic analysis processes known as whole transcriptome pathway analysis to identify which genes were activated, and which might be associated with the anorexia nervosa disorder specifically.

They found unusual activity in the neurons from the patients with anorexia nervosa, helping them identify a gene known as TACR1, which uses a neurotransmitter pathway called the tachykinin pathway. The pathway has been associated with other psychiatric conditions such as anxiety disorders, but more pertinent to their study, says Mutori, is that tachykinin works on the communication between the brain and the gut, so it seems relevant for an eating disorderbut nobody has really explored that. Prior research on the tachykinin system has shown that it is responsible for the sensation of fat. So if there are misregulations in the fat system, it will inform your brain that your body has a lot of fat.

Indeed, they found that the AN-derived neurons had a greater number of tachykinin receptors on them than the healthy control neurons. This means they can receive more information from this neurotransmitter system than a normal neuron would, Muotri explains. We think this is at least partially one of the mechanisms that explains why [those with anorexia] have the wrong sensation that they have enough fat.

In addition, among the misregulated genes, connective tissue growth factor (CTGF), which is crucial for normal ovarian follicle development and ovulation, was decreased in the AN samples. They speculate that this result may explain why many female anorexia patients stop menstruating.

Muotrinext wants to understand what he calls the downstream effect of those neurons with too many TACR1 receptors. In other words, how does it affect the neurons at a molecular level, and what information do those neurons receive from the gut? This link between the brain and the gut is unclear, so we want to follow up on that, he says.

He also wants to look into thepotential to design a drug that could compensate for the large amount of TACR1 receptors, and the over-regulation of that receptor in the brainwhich would be a huge development for the notoriously difficult-to-treat disease.

While Muotri is excited about new avenues of research that can follow from this work, he doesn't see it as a panacea for the disease, but a way to begin to understand it more fully. He says, Its a good start, but arguably you have to understand what are the other environmental factors that contribute.

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FDA fast-tracks Nebraska Medicine clinical trial – WOWT

Posted: at 8:32 pm

OMAHA, Neb. (WOWT) -- This week, researchers unveiled encouraging news in the fight against cancer as the FDA fast-tracked a specific type of gene therapy. Nebraska Medicine is one of only a handful of cancer in the country participating in a clinical cancer for non-Hodgkins lymphoma.

Amy Cheese, a 3rd grade teacher from Colorado stepped away from the classroom last year hoping to find a treatment that would save her life. She had run out of treatment options for her cancer in the blood.

Nothing was shrinking the grapefruit-sized tumor in her chest.

So she came to Omaha where her CAR t-cells would get a science make-over.

It works like this: we all have t-cells to fight infection. But in a cancer patient, they go haywire.

Her cells are sent from Omaha to a California lab to be re-engineered, and returned two weeks later to pinpoint the cancer and destroy it.

We were there in January when Dr. Julie Vose in Oncology revealed whether the therapy was working for Amy.

Dr. Vose: Continuing improvement. Its now 2.7 and that means complete remission. Amy: Oh really. Wow. I have to hug Susan. Susan: Its awesome. Amy: I didnt think it was ever going to happen. Thats what everybody wants to hear. Complete remission.

Successful cases like Amy Cheeses has the FDA expanding the reach of the clinical trials.

About 60% of the patients had a complete remission, said Dr. Vose in an interview with WOWT 6 News this week. Meaning that at the end of the therapy theres no sign of the lymphoma. 3-months after that there was 40% of the patients in complete remission, which may not seem like a lot but these are patients who had failed every other therapy they could possible fail.

Amy Cheese recently had her 6-month check-up. She remains in complete remission.

Doctors believe this breakthrough cancer therapy could one day apply to all cancers. As a big picture, said Dr. Vose, I think it has huge and incredible potential.

With the FDA fast-tracking this method, doctors say more patients will now be a part of a larger clinical trial.

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Ovarian cancer patients get access to life-extending drug – Medical Xpress

Posted: at 8:32 pm

April 7, 2017 Susan Ross with her partner Paul Appleby. Credit: Newcastle University

Cancer patients in America are now receiving a life-extending drug developed by scientists at Newcastle University.

Women with recurrent ovarian cancer have access to the pioneering treatment, Rubraca, following approval of the drug in the USA by the Food and Drug Administration (FDA).

First discovered approximately 20 years ago, and arising from research initiated at Newcastle University by Cancer Research UK-funded scientists, Rubraca has been approved for ovarian cancer patients with a faulty BRCA gene.

Studies have shown that the oral medication has a high success rate as 54% of women on clinical trials had complete or partial shrinkage of their tumour for an average of 9.2 months.

It is hoped that Rubraca will get approval by the European Medicines Agency within the next year. If then approved by the National Institute for Health and Care Excellence and the Scottish Medicines Consortium, it would allow ovarian cancer patients in the UK with a BRCA gene mutation to access the new treatment.

Dr Yvette Drew, Senior Lecturer at Newcastle University and Honorary Consultant in Medical Oncology at Newcastle upon Tyne Hospitals NHS Foundation Trust, has led the clinical development of Rubraca in the North East.

She said: "It is fantastic that patients are now receiving Rubraca and we are hopeful that women in Britain will also have the opportunity to access this ground-breaking treatment in the future.

"Rubraca is a well-tolerated oral drug, allowing women to have a better quality of life for longer without debilitating side-effects that are often seen with chemotherapy.

"The approval of this medication is a great achievement for the Newcastle University team and is an example of what can be achieved when scientists and oncologists work together to target a specific type of cancer at the molecular level."

Rubraca, also known as rucaparib, is a class of drug called a PARP inhibitor which exploits a defect in the cancer cell's ability to repair normal wear and tear to its DNA to kill the tumour cells without unduly harming healthy cells.

The FDA has approved the use of Rubraca for women with ovarian cancer who have been treated with two or more chemotherapies and whose tumours have a BRCA mutation.

Each year, around 7,000 women are diagnosed with ovarian cancer across the UK and one in 50 women will develop ovarian cancer at some point in their life.

Around 15% to 20% of women with ovarian cancer will have a BRCA gene mutation, putting them at increased risk of developing other cancers and a 50% risk of passing the faulty gene to their children.

Ruth Plummer, Clinical Professor of Experimental Medicine at the Northern Institute for Cancer Research, Newcastle University, was the first clinician to prescribe Rubraca.

Professor Plummer, Consultant Medical Oncologist at Newcastle upon Tyne Hospitals NHS Foundation Trust, said: "The licensing of Rubraca by the FDA is very exciting and the culmination of many years of work by cancer researchers in Newcastle.

"We have been seeing patients benefit clinically from PARP inhibitors in clinical trials for a number of years and it is fantastic that this drug will now become more widely available."

Newcastle University researchers - Professors Hilary Calvert, Nicola Curtin, Barbara Durkacz, Bernard Golding, Roger Griffin, Herbie Newell and Ruth Plummer - were part of a multi-disciplinary team that discovered and developed Rubraca.

Emma Greenwood, Cancer Research UK's director of policy, said: "We're delighted that Rubraca has been licensed for use by the FDA, particularly when Cancer Research UK-funded scientists working at Newcastle University discovered and developed the drug in the early 1990s in collaboration with industry partners.

"The drugone of an exciting group of drugs that exploit the weaknesses cancer cells have in repairing damaged DNAwill offer new hope to women with advanced ovarian cancer.

"We hope it could one day treat other cancer types and clinical trials are underway to discover its potential."

Patient's story

Susan Ross has been on Rubraca under Dr Drew's care at the Freeman Hospital's Northern Centre for Cancer Care in Newcastle for more than a year and is living life to the full.

The 59-year-old, of Whitley Bay, was diagnosed with ovarian cancer with a BRCA gene mutation 10 years ago and says she feels great after being given the drug as part of a clinical trial.

Susan has been on Rubraca since December 2015 when her ovarian cancer returned and was not operable. Her tumour has shrunk completely and she continues to receive the treatment as part of a clinical trial.

She said: "I feel the best I've felt since before my ovarian cancer diagnosis in 2007. I have my life back and I've been to far afield countries like Australia and Japan.

"I'm so lucky to have been given Rubraca as part of a clinical trial and it is great patients in America are able to access this treatment - I hope patients in the UK will also have this opportunity in the future.

"The team at Newcastle University should be very proud of what they have achieved as Rubraca is offering hope to ovarian cancer patients with the BRCA gene mutation that they can live their life well.

"Since I have been on Rubraca I've felt well enough to get a part-time job and I'm also considering taking up golf.

"I would like to thank all those who have been involved in Rubraca's development and to the clinical team who have looked after me so well."

Susan underwent four operations and three rounds of chemotherapy before being enrolled on the clinical trial. She continues to be closely monitored with regular CT scans.

Explore further: FDA clears ovarian cancer drug for hard-to-treat disease

U.S. health officials have approved a new option for some women battling ovarian cancer: a drug that targets a genetic mutation seen in a subset of hard-to-treat tumors.

About one-third of patients with ovarian cancer who wouldn't be expected to respond to a PARP inhibitor had partial shrinkage of their tumor when a kinase inhibitor was added to treatment, report scientists from Dana-Farber ...

(Medical Xpress) -- Cancer Research UKs Drug Development Office has re-launched a trial of a promising drug to treat inherited breast and ovarian cancer but this time taken as a tablet by outpatients.

According to the Centers for Disease Control and Prevention, more than 20,000 women in the U.S. are diagnosed with ovarian cancer each year. September is Ovarian Cancer Awareness month and physicians want to raise awareness ...

(Medical Xpress)A new cancer drug designed to be effective in tumours with faulty BRCA genes has generated impressive responses in an early-stage clinical trial.

A pioneering cancer drug set to become the first to be approved specifically for inherited cancers could also be used much more widely to treat prostate cancer, a world-leading expert said today.

A world-first book combining evolutionary ecology and oncology aims to improve cancer prevention and therapies.

More typically, these immature immune cells might help us fight cancer, but scientists have now shown cancer can commandeer the cells to help it spread.

A team of investigators has determined that young children participating in a clinical trial to assess the effectiveness of reduced radiotherapy did worse when there were deviations from the treatment protocol. Results of ...

Australian scientists have uncovered a promising new approach to treating pancreatic cancer, by targeting the tissue around the tumour to make it 'softer' and more responsive to chemotherapy. The findings are published today ...

A study of nearly 280,000 women in the United States has found that living in areas with a high level of fine particles from air pollution may increase a woman's chance of having dense breasts - a well-established risk factor ...

In 2016, more than 181,000 new cases of prostate cancer were reported in the U.S., according to the American Cancer Society. The prostate-specific antigen (PSA) test is one of the earliest ways clinicians can detect prostate ...

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Don Rickles’ best lines that were beyond politically incorrect – New York Daily News

Posted: at 8:32 pm


New York Daily News
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Should College Campuses Be Politically Correct? – Study Breaks

Posted: at 8:32 pm

University faculty strive to do what is best for students, and sometimes, its not what they want.

By Madeleine Ngo, University of Florida

Ben Shapiro, a popular conservative political commentator, was the latest guest speaker at the University of Florida, and most students were not happy about it.

There were numerous editorials and opinion columns centered around Shapiro and whether or not he should be recognized for his often-extreme conservative views. Many campus protests were filled with actual protesters, and then later, Shapiro supporters.

Some students argue that they shouldnt have to pay for hateful speakers to visit their campus, while others support Shapiros beliefs. In the end, the main question is: Should college campuses be politically correct (PC)?

The answer isnt completely clear. For the most part, having an entirely politically correct campus would be absurd. Students shouldnt be shielded from perspectives that dont align with their own beliefs. They can benefit from hearing other perspectives, because it promotes active discussion rather than outright shaming each others beliefs without justification.

UF Protest Against Shapiro (Image via Wuft)

There have been some weird moments resulting from promoting a PC campus; the University of Wisconsin-Milwaukee deemed the term politically correct as being politically incorrect, claiming that the term is offensive and used as a toolof deflection.

In the end, there isnt a perfect solution. Sometimes, there are appropriate times for political correctness, and sometimes there arent. Protests and campus debates are beneficial for students, especially at a time when students political and social beliefs are beginning to formulate.

By having a PC campus, though, the probability of increased debates and people vocalizing their opinions begins to diminish. University officials shouldnt shield students from other peoples beliefs, no matter how bigoted or offensive they may be.

Rather than focusing on discounting other viewpoints, students should actively engage with people who dont share the same beliefs. By doing so, students will be able to challenge the beliefs of others, like Shapiro, and learn from each other. Maybe youll leave more frustrated than before, but you cant challenge and reinforce your beliefs without exposing yourself to other opinions first.

In an op-ed piece in the Wall Street Journal, Michael Bloomberg and Charles Koch argue against a politically correct campus, claiming that safe spaces would hinder free speech and result in students being unable to tolerate differing beliefs that they may encounter beyond their university years.

They urge college administrators to prevent measures promoting a politically correct campus, saying, Stop stifling free speech and coddling intolerance for controversial ideas, which are crucial to a college educationas well as to human happiness and progress.

No group is perfect. In the case of the protesters, college campuses should be less focused on being politically correct and, instead, promote open-mindedness and free speech. On the other hand, offending others isnt ideal, and calling the protesters sensitive will most likely end up backfiring, creating more resentment than before.

Rather than condemning others and making base assumptions, question them. Ask them why they believe in something rather than calling them liberal snowflakes or preventing political commentators from speaking on campus. Institutions, like the University of Chicago (UC), seem to have an ideal grasp of how to handle a politically incorrect campus.

Students in Support of Shapiro (Image via Alligator)

In UCs welcoming letter to the incoming class of 2020, Dean of Students John Ellison writes, Our commitment to academic freedom means that we do not support so-called trigger warnings, we do not cancel invited speakers because their topics might prove controversial, and we do not condone the creation of intellectual safe spaces, where individuals can retreat from ideas and perspectives at odds with their own.

Although its a contentious topic, UC officials are firm in their beliefs and reinforcement of a non-PC campus in an effort to promote a wide range of student perspectives. Maybe youre sick of hearing about political correctness, but its important to discuss the repercussions of restricting students from differing viewpoints.

Despite how extreme peoples beliefs may be, they should be allowed to have a platform to voice their opinions and be questioned. A productive society results from discussion. Once students are exposed to different views, they are able to more effectively formulate their own opinions after learning about the facts and considering a multitude of perspectives.

A completely politically correct campus would be an unproductive way for students to decide what they believe in. Differing beliefs shouldnt be shamed, but rather challenged. Free speech is an essential component of a progressive society, one that isnt caught up in what is or what isnt deemed politically correct.

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German Proposal Threatens Censorship on Wide Array of Online Services – Center for Democracy and Technology (blog)

Posted: at 8:31 pm

Anticipating federal elections in September, Germanys Minister of Justice has proposed a new law aimed at limiting the spread of hate speech and fake news on social media sites. But the proposal, called the Social Network Enforcement Bill or NetzDG, goes far beyond a mere encouragement for social media platforms to respond quickly to hoaxes and disinformation campaigns and would create massive incentives for companies to censor a broad range of speech.

The NetzDG scopes very broadly: It would apply not only to social networking sites but to any other service that enables users to exchange or share any kind of content with other users or make such content accessible to other users. That would mean that email providers such as Gmail and ProtonMail, web hosting companies such as Greenhost and 1&1, remote storage services such as Dropbox, and any other interactive website could fall within the bills reach.

Under the proposal, providers would be required to promptly remove illegal speech from their services or face fines of up to 50 million euros. NetzDG would require providers to respond to complaints about Violating Content, defined as material that violates one of 24 provisions of the German Criminal Code. These provisions cover a wide range of topics and reveal prohibitions against speech in German law that may come as a surprise to the international community, including prohibitions against defamation of the President (Sec. 90), the state, and its symbols (Sec. 90a); defamation of religions (Sec. 166); distribution of pornographic performances (Sec. 184d); and dissemination of depictions of violence (Sec. 131).

NetzDG would put online service providers in the position of a judge, requiring that they accept notifications from users about allegedly Violating Content and render a decision about whether that content violates the German Criminal Code. Providers would be required to remove obvious violations of the Code within 24 hours and resolve all other notifications within 7 days. Providers are also instructed to delete or block any copies of the Violating Content, which would require providers not only to remove content at a specified URL but to filter all content on their service.

The approach of this bill is fundamentally inconsistent with maintaining opportunities for freedom of expression and access to information online. Requiring providers to interpret the vagaries of 24 provisions of the German Criminal Code is a massive burden. Determining whether a post violates a given law is a complex question that requires deep legal expertise and analysis of relevant context, something private companies are not equipped to do, particularly at mass scale. Adding similar requirements to apply the law of every country in which these companies operate (or risk potentially bankrupting fines) would be unsustainable.

The likely response from hosts of user-generated content would be to err on the side of caution and take down any flagged content that broaches controversial subjects such as religion, foreign policy, and opinions about world leaders. And individuals inside and outside of Germany would likely have minimal access to a meaningful remedy if a provider censors their lawful speech under NetzDG.

The proposal is also completely out of sync with international standards for promoting free expression online. It has long been recognized that limiting liability for intermediaries is a key component to support a robust online speech environment. As then-Special Rapporteur for Freedom of Expression, Frank La Rue, noted in his 2011 report:

Holding intermediaries liable for the content disseminated or created by their users severely undermines the enjoyment of the right to freedom of opinion and expression, because it leads to self-protective and over-broad private censorship, often without transparency and the due process of the law.

The Council of Europe has likewise cautioned against the consequences of shifting the burden to intermediaries to determine what speech is illegal, in conjunction with the report it commissioned in 2016 on comparative approaches to blocking, filtering, and takedown of content: [T]he decision on what constitutes illegal content is often delegated to private entities, which in order to avoid being held liable for transmission of illegal content may exercise excessive control over information accessible on the Internet.

Shielding intermediaries from liability for third-party content is the first of the Manila Principles on Intermediary Liability, a set of principles supported by more than 100 civil society organizations worldwide. The Manila Principles further caution that Intermediaries must not be required to restrict content unless an order has been issued by an independent and impartial judicial authority that has determined that the material at issue is unlawful. It is a mistake to force private companies to be judge, jury, and executioner for controversial speech.

CDT recommends that the German legislature reject this proposed measure. It clearly impinges on fundamental rights to free expression and due process. The challenges posed to our democracies by fake news, hate speech, and incitement to violence are matters of deep concern. But laws that undermine individuals due process rights and co-opt private companies into the censorship apparatus for the state are not the way to defend democratic societies. Governments must work with industry and civil society to address these problems without undermining fundamental rights and the rule of law.

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Trigger Warning: A High School Censors A Speech About Censorship – Forward

Posted: at 8:31 pm

Wallkill Senior High School just censored my lecture about censorship.

Several months ago, the school in an upstate New York community known for its prisons and apple orchards invited me to participate in its annual Authors Day event on April 4 and 5. Published writers gab to administrators, librarians and educators over a buffet dinner and then lecture to several classes of students the following day. Its a schlep from Manhattan, but writers receive a modest honorarium and I enjoy talking to kids about my passion.

The talk focused on my book, Killed Cartoons: Casualties From The War On Free Expression (W.W. Norton), a collection of editorial art that newspapers and magazines deemed too controversial to publish. The schools website graciously described me as a top journalist on the front lines of world news and politics who has written 2 critically acclaimed books on the censorship of political cartoons and news articles.

Now I had been warned that the school is located in a conservative district, and I understood that the underlying topic of my talk the embattled free press in the Trump era could prove controversial. But the school should have known what it was getting into. After all, I did not write a young adult novel about a talking purple whale, but hard-hitting nonfiction books on censorship. And my first audience primarily educators with a mission to opening minds for a living would, I assumed, be interested in my message even if it werent exactly theirs.

I assumed wrong.

Around dessert time, I walked to the lectern in the neighborhood Italian restaurant and joked that the audience would be getting a second helping of broccoli.

Unlike the other authors, creators of childrens books who spoke ad hoc about how they became writers, I prepared remarks, because I had something important to say: The leader of the free world has declared war on our free press, and his multi-pronged assault endangers our democracy.

On February 24, President Trump stood before an audience at the Conservative Political Action Conference in Washington, D.C., and smeared journalists by calling them enemy of the people.

That particular phrase, enemy of the people, holds a sinister place in the history of political rhetoric, as I told my fidgety audience. Among those who have launched such verbal missiles to demonize their opponents are Adolf Hitlers minister of propaganda, Joseph Goebbels, who labeled Jews enemies of the German people murderous Chinese dictator Mao Zedong, and Russian autocrat Joseph Stalin.

As the BBC recently recounted, during Stalins long, brutal reign, out-of-favour artists and politicians were designated enemies and many were sent to hard labour camps or killed. Others were stigmatised and denied access to education and employment.

People stared at their brownies and avoided my eyes, except some of the bulked-up guys, maybe gym teachers, who looked like they wanted to fire a dodge ball at my head.

I then noted that just last week, in a tweet that sailed mostly under the radar, Trump, who has sued journalists for writing unflattering stories about him in the past, proposed weakening the laws protecting a free press. The failing @nytimes has disgraced the media world. Gotten me wrong for two solid years, he wrote, ominously adding, Change libel laws?

Eviscerating the laws protecting publishing (which is not unimaginable if Senate Republicans eliminate the filibuster for legislation, as some observers believe will happen) would make it much harder for journalists to do our jobs exposing public corruption and corporate malfeasance and much easier for the super-rich and big business to suppress the truth.

The Trump administrations assault on the media goes beyond attempts at intimidation. The presidents recent budget proposal would eliminate the relatively modest government support for the Corporation for Public Broadcasting, one of the most respected sources of news in the country.

I also pointed out that Trump doesnt hate all media. In fact, hes a fan of Alex Jones, a racist radio host who argued that 9/11 was an inside job perpetrated by the U.S. government, and that the Sandy Hook massacre in Newtown, Connecticut, was a giant hoax.

Not long after Trump launched his presidential campaign, he appeared as a guest on Joness InfoWars show to flatter the host. Your reputation is amazing, gushed the president, a comment that I still find amazing.

Someone walked out about then. Not slinked out to the bathroom, but marched out in audible disgust. Now I know how comedians feel when they bomb.

Maybe some history will work, I thought to myself.

Our Founding Fathers understood that a vibrant, independent press and a well-informed citizenry stood in the way of tyranny and was essential to the success of their experiment, as they referred to democracy. Thats why they included freedom of the press in the First Amendment. Unfortunately, only 11% of Americans could identify freedom of the press as a constitutionally enshrined First Amendment right, according to the Newseum Institute.

Thomas Jefferson, who endured intense scrutiny from reporters during his presidency, nevertheless consistently defended the field of journalism. Were it left to me, he wrote in 1787, to decide whether we should have a government without newspapers or newspapers without government, I should not hesitate for a moment to prefer the latter.

Donald Trumps war on the press has prompted protests from prominent members of his own party. Former president George W. Bush, hardly a liberal, pointed out that we need the media to hold people like me to account. I mean, power can be very addictive and it can be corrosive and its important for the media to call to account people who abuse their power.

Without a free press, Sen. John McCain worried that we would lose so much of our individual liberties over time thats how dictators get started.

That approach didnt work either, so I wrapped up, explaining that the administrations palpable hostility prompts some media organizations to rededicate themselves to the mission of public interest journalism and others to cower in fear and engage in self-censorship. And, that editorial cartoonists are arguably the most vulnerable of journalisms foot soldiers, given the simple power of their expression. A vulnerability shown by the number of full-time cartoonists at newspapers dropping, from about 2000 in the year 1900, to around 90 when I published my book in 2007, and fewer than 30 today.

Reprinted with permission of Paul Combs.

Killed by the Tampa Tribune, 2005.

Youve been a terrific audience

Keepin it light, David, said one of my hosts, who later delivered the news by phone that my talk to the students the next day would be canceled due to a scheduling conflict. I am pretty sure that the other authors, who discussed less contentious topics, such as the teacher who first inspired them to read, spoke right on schedule.

The students arguably are the ones losing out. They would have benefited from a interacting with a professional journalist with experience on the front lines of world news and politics, and by civilly discussing polarizing issues with someone they might not necessarily agree with.

Still, I learned a few lessons from the experience: The divisions in this country are deeper than I expected; people seem less willing than ever to engage in debate, and the status of the press down to about 20% in 2016 from 51% in 1979, [according to Gallup], (http://www.gallup.com/poll/195542/americans-trust-mass-media-sinks-new-low.aspx) is seriously damaged, hindering our ability to effectively communicate sometimes difficult-to-digest truths.

On the bright side, at least I didnt have to eat lunch in the cafeteria.

David Wallis is the Forwards opinion editor. Contact him at wallis@forward.com

The views and opinions expressed in this article are the authors own and do not necessarily reflect those of the Forward.

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Trigger Warning: A High School Censors A Speech About Censorship - Forward

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It happened! Cork conference overcomes academic censorship … – Mondoweiss

Posted: at 8:31 pm

(Photo: the International Law and the State of Israel: Legitimacy, Exceptionalism and Responsibility conference)

It was originally scheduled in 2014 for the Britains Southampton University and was canceled after Zionists pressured university officials. It was briefly rescheduled once more in Southampton in response to outrage over the censorship only to be canceled once again. However, lead organizers, Oren Ben-Dor, James Bowen and George Bisharat did not give up. In the intervening months questions about the legitimacy of Israeli government actions only increased, and the original conference organizers were joined by more scholars and international legal experts determined to carry out a serious discussion about Palestine and international law.

For many of the attendees, the timing this spring couldnt have been better. The ascendancy of the right wing in Europe and the United States and the recent vociferous reactions to the UN report by Richard Falk and Virginia Tilley made the discussions all the more timely and necessary. The warm Irish welcome was such that the first two days were actually held in the atrium auditorium of Corks City Hall. The sessions were packed at both City Hall and the Sunday session at the University of Cork. Although there was security hired by conference organizers, there were no violent incidents, nor even any sustained complaints from the audience. The only sustained reactions were the enthusiastic applause outbursts whenever the courage and persistence of the conference organizers was mentioned.

Eitan Bronstein from the Israeli human rights group Zochrot speaks at the International Law and the State of Israel: Legitimacy, Exceptionalism and Responsibility conference. (Photo: Facebook)

Richard Falk, co-author of the recent UN report:Israeli Practices towards the Palestinian People and the Question of Apartheid, commissioned and published by the UN Economic and Social Commission for Western Asia (ESCWA),was the first keynote speaker with amagisterial overview of the legal history of the state formation of Israel. Ugo Mattai from the University of Turin and Hastings College of Law was the keynote for the second day and gave an eloquent perspective on the functional limits of international law. Other presenters included Ghada Karmi, University of Exeter; Vasuki Nesiah, NYU; Anthony Lowstedt, Webster University in Vienna; anti-house demolition Activist Jeff Halper; London barrister Salma Karmi-Ayyoub; Jaffa journalist Ofra Yeshua-Lyth; Joel Kovel, NY writer and activist and many others.

The sessions, listed with titles such as Legitimacy, Self Determination and Political Zionism and Settler Colonialism: Exceptional or Typical, could have veered off into repetitive rhetoric and bitter denouncements, but the skillful panel arrangements and choice of speakers by the organizers made for thoughtful, though sometimes intense discussion and reflection.

Joel Kovel, speaking at Cork conference

Several key Jewish academics and the presentation by Buckingham Professor Geoffrey Alderman insured that pro-Israel voices were also presented. The only tense moment came when someone in the audience questioned a panelists contention that Israeli children are being taught to hate. That discussion was quickly defused by expanding to include statements about diverse cultures and the need to empathize with the other.

One of the sessions on the last day was enhanced with a variety of maps. Instead of the usual depressing images of encroaching wall construction and escalating settlement development, in this discussion the maps were shown as possible guides for potential future reconciliation and repatriation. Dr. Salman Abu-Sitta from the Land Society of Palestine showed slides of map points locating carefully researched sites of former Palestinian homes and villages placed over a map of current Israeli population centers. When viewed via his overlapping graphics, one could see that there was room on the land for ensuring space for the right to return. As an experienced civil engineer, Abu-Sitta outlined some of the planning and construction that could be created for a truly authentic peace process. His plan, he assured the audience, would cost a lot less than even one year of U.S. aid to Israel, and, as he pointed out, would only be a one-time cost, not an annual expenditure. One should be cautious about any technological solution to human problems, but Abu-Sittas positive and good humored look at what has been such an insoluble issue was refreshing and persuasive.

Eitan Bronstein Aparicio also used cartography in a positive presentation. He passed out copies of a large fold-out map which shows the many historic settlements that were destroyedbut not just Palestinian ones. His map includes Jewish and Syrian destructions also from way before 1948 until 2016. This is part of the extensive work Bronstein Aparicio has done to increase understanding of the history of land and population centers for both Israelis and Palestinians.

Throughout the conference, there were occasional Thoughts for the Day by Philip Franses, a representative from the Schumacher College. These short presentations must have been scheduled by the organizers to circumvent what was the anticipated dissension. Like the bored security personnel, these hedges against rancor were completely unnecessary at this overwhelmingly positive and hopeful conference. The expected dissension was non-existent and these programmed new age moments seemed forced and patronizing. The mantra of were all equal humans and we are the world moments seemed rather insulting.

The final panel included a presentation by Cheryl Harris, Professor ofConstitutional Law at UCLA, who began with a review of events in Ferguson, Missouri, and a short history of the Black Lives Matter movement. According to Harris, this movement has become aware of the need to connect with international struggles against racism and the global struggle for justice. Both Harris and Richard Falk adroitly, with diplomatic grace, responded to the feel good, everyones equal proscription by reminding the audience that Franses confident rhetoric did not take power into account. Yes, all lives do matter, but a togetherness chant is not going to remedy unjust situationsin Missouri or Palestine.

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It happened! Cork conference overcomes academic censorship ... - Mondoweiss

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Political Correctness Isn’t About Censorship It’s About Decency – Huffington Post

Posted: at 8:31 pm

What I think the political correctness debate is really about is the power to be able to define. The definers want the power to name. And the defined are now taking that power away from them.Toni Morrison

Never trust anyone who says they do not see color. This means to them, you are invisible.Nayhyirah Waheed

Not Steven. Not Stephen. Certainly not Steveareno.

Its a preference. My preference. My choice. And if people want to be in my good graces, theyll comply with my wishes.

Theres nothing strange or unreasonable about this. We do it all the time usually when were being introduced to someone.

Nice to meet you, Steve. Im Elisha.

Elisha? What a beautiful name!

Please. Call me Steve.

Is there anything wrong with that? Does that stifle conversation? Does it stop people from talking freely to each other?

No. Certainly some names are hard to pronounce or in my case remember. But overcoming those hurdles is just common decency. Its not too much to ask especially if youre going to be dealing with this person for an extended length of time.

The idea that allowing people to define themselves somehow shuts down conversation is rather strange. But its the essence of opposition to political correctness.

Political correctness is tyranny with manners, said conservative icon Charlton Heston.

I wonder if he would have felt the same if wed called him Charlie Hessywessytone.

A more fleshed out criticism comes from President George H. W. Bush who said, The notion of political correctness declares certain topics, certain expressions, even certain gestures off-limits. What began as a crusade for civility has soured into a cause of conflict and even censorship.

Is that true? Is political correctness really censorship? Thats the conflation made by many conservatives and even some liberals. After all, popular Left-wing comedian Bill Maher sarcastically calls his HBO show Politically Incorrect, and he often rails against the practice.

Theres a kernel of truth to it. We are asked to change the way we speak. Were asked to self-censor, but we already do this frequently without wailing against a loss of free speech.

Human beings are subject to various impulses, but as adults, we learn which ones we can act on and which we shouldnt. I may think it would be hilarious to run into a crowded movie theater and yell, FIRE! However, I know that doing so while possibly funny to a certain kind of person would result in injuries and trauma as moviegoers stampede out of the theater. So I dont do it. Is that censorship? Maybe. But its censorship with a small c.

The Hestons, Bushes and Mahers of the world seem to think political correctness is more like Capital C Censorship. But this is demonstrably false.

That kind of Censorship is the act of officials, possibly agents of the government, a corporation or some other formal bureaucracy. But political correctness has nothing to do with officials. There are no censors. There are only people who ask to be named a certain way.

A censor looks at a news report of military operations in Iraq and deletes material that would give away the armys location. Political correctness is nothing like that. It involves someone asking others to refer to themselves THIS WAY and not THAT WAY.

The penalties for violating Censorship are official. Ask Chelsea Manning who until being pardoned by President Barack Obama - was serving a 35-year prison sentence for doing just that. The penalties for violating political correctness are social. You may be criticized, condemned or disliked.

If you criticize Manning for releasing classified documents to Wikileaks, youre not violating political correctness. Thats your opinion, and youre entitled to it. However, Manning is a trans woman who is going through hormone replacement therapy. If you refer to her as him you are violating political correctness. Youre naming her in a way that violates her wishes. The penalty is not a prison sentence. Its a sour look.

So political correctness is not Censorship. In some ways, the confusion comes from the term political correctness, itself.

Though its origins are hard to pin down, it appears to have been coined by the Soviets to mean judging the degree of compatibility of ones ideas or political analysis with the official party line in Moscow. At least thats what the International Encyclopedia of Social Studies says.

The term came to prominence in the United States in conservative writer Dinesh DSouzas book Illiberal Education. He disparaged affirmative action as a kind of political correctness that gave preference to (what he saw as) unqualified minority students over whites in college admissions.

So the first mention of the term in the USA was simply to disparage liberal political policies. It was a ham-handed way of comparing the Left with the Soviets. Yet somehow this term has become the handle by which we know simple civility. Its kind of hard to feel positively about a concept that begins with a mountain of unearned negative connotations.

Conservatives know the power of getting to name something. Its their go-to propaganda tactic and lets them control much of the debate. For instance, thats why the Right loves to call Social Security an entitlement. Theres truth to it because youre entitled to getting back the money you pay in, but its full of unearned negative connotations as if these people were somehow demanding things they dont deserve.

In essence, political correctness shouldnt be political at all. Its just kindness. Its just being a decent human being. Dont purposefully call someone by a name they wouldnt appreciate. Respect a persons ownership of their own identity.

And for some people thats hard to do. Their conceptions of things like gender, sexuality, race and religion are extremely rigid. The only way to be a man is THIS WAY. The only way to be spiritual is THAT WAY. But if they give voice to these ideas in the public square especially in the presence of people who think differently they will be frowned upon.

But is this really so dissimilar to the crowded movie theater? Refusing to acknowledge someone elses identity is harmful to that person. It tramples the soul,similarly to the way their body would be trampled in a stampeded exit. So you shouldnt do it.

The result is an apparently much more tolerant society. Its no longer okay to use racial, cultural, gender and sexual stereotypes in public. Youre forced to give other people consideration or else face the consequences of being disliked. And on the surface, thats a much more inviting world to live in.

However, there is a glaring problem. In some ways, this has made public discourse more antiseptic. People dont always say what they mean in the public square. Its not that theyve changed the way they think about the world. Theyve just learned to keep it to themselves until theyre around like-minded individuals. They reserve their racist, classist, sexist language for use behind closed doors.

This is why when Im at a party peopled exclusively by white folks, some partygoers may let racial epithets slip out. And we all laugh nervously to be polite. Or maybe its more than politeness. Maybe for some its to relieve the tension of such refreshing candor like taking off a girdle. Fwew! Here, at least, I can say what I really think without having to worry about people looking down on me for it!

Since such reactions occur mostly in homogeneous groups, it makes the world look much more enlightened than it really is. Pundits and policymakers look around and cheer the end of these social ills when they havent ended at all. Theyve merely gone underground.

And so we have an epidemic of colorblind white people who cant see racism because of the gains of political correctness. Somehow they forget those unguarded moments. Somehow they havent the courage to examine their own souls. Or perhaps they dont care.

And so we have the conundrum: which is better to live in a world where all individuals have the right to name themselves or to live in a world where our most basic prejudices are on display for all to see?

Personally, I pick political correctness, and heres why.

Words are important. We think in words. We use them to put together our thoughts. If we continue to respect individuals names in word, eventually well begin to do so in thought and deed.

This isnt mind control. Its habit. Its recognizing an ideal and working toward it. As Aristotle taught, the way to become a good person is to act like one. Eventually, your preferences will catch up with your habits.

I think thats whats happening today. Look at the children. Theyre so much less prejudiced and racist than we, adults. This is because theyve learned political correctness first. They didnt have to unlearn some archaic white-cisgender-centrism. This is normal to them, and I think thats a good thing.

Obviously some people will balk at this idea. They will look at this ideal as reprehensible. They want to return to a world where women were little more than property, a world where black people knew their place, where sexual identity was as simple as A or B.

But I think most of us recognize that this is not a world where wed want to live. Modern society can be scary and confusing but trying to respect everyone as a person isnt a bad thing. Its consideration, concern, warmth.

Perhaps the best way to love your fellow humans is to call them by their proper names.

A similar version of this article originally was published on my Website.

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