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Category Archives: Transhuman News

Astronaut, Cosmonaut And Stuffed Dog Arrive At International Space Station – NPR

Posted: April 21, 2017 at 2:04 am

A Soyuz spacecraft carrying a new crew to the International Space Station, ISS, blasted off Thursday from the Baikonur cosmodrome in Kazakhstan. Dmitri Lovetsky/AP hide caption

A Soyuz spacecraft carrying a new crew to the International Space Station, ISS, blasted off Thursday from the Baikonur cosmodrome in Kazakhstan.

In case you ever find yourself hurtling into space, know this: When the little stuffed dog starts to float, that's when you've reached Earth's orbit.

NASA astronaut Jack Fischer and Russian cosmonaut Fyodor Yurchikhin lifted off from Kazakhstan on Thursday, bound for the International Space Station. About nine minutes into their voyage, the stuffed dog leaped into the air, then began to drift at the end of the string around its neck. (The dog is the latest in an adorable tradition of stuffed animals in space.)

There was a rare extra seat in the Soyuz capsule; Reuters reports that Russia is scaling back its space station staffing as it prepares to prepares to send a laboratory to the ISS next year.

It's the fifth mission to the space station for Yurchikhin, but the first for Fischer, who he says there is one aspect of space station life that you can't train for on Earth: using a zero-gravity toilet.

"It's all about suction, it's really difficult," Fischer said in a NASA interview before launch. "You just can't train for that on the ground, so I approach my space-toilet activities with respect, preparation and a healthy dose of sheer terror."

Just six hours after launch, the pair docked at the space station. They were welcomed by Flight Engineers Oleg Novitskiy of Russia and Thomas Pesquet of the European Space Agency, as well as Expedition 51 Commander Peggy Whitson of NASA, who on Monday will break the record for longest time spent in space by a U.S. astronaut. She's due to return to Earth in September.

On Saturday, NASA will livestream video of the Orbital ATK Cygnus cargo spacecraft rendezvous and capture at the International Space Station. The cargo craft took off from Cape Canaveral in Florida on Tuesday.

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Mysterious ‘Alien’ cylinder on NASA live feed for International Space Station spotted by space experts – Mirror.co.uk

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NASA's live feed of the International Space Station (ISS) captured a mysterious object, which UFO experts claim is an alien cylinder that goes transparent.

The odd shape was spotted in a black space behind the ISS by space fans watching the live feed.

And experts said the cylinder - which they claim was a UFO - was 'partially transparent', which may be a technique used to keep the craft safe so that it is not seen.

UFO expert Scott C Waring, shared the footage and said: "I noticed a UFO in the distance that was coming closer and closer to the space station. The UFO was partially cloaked, which made it look transparent."

Mr Waring runs the website UFO Sightings Daily ,

He added: "In the deep blackness of spaces, blending into the environment means you will be safer from other alien species that may not be friendly."

It is not the first time objects have been spotted on the ISS feed without explanation.

In February, six large orbs were seen apparently creeping past the ISS in NASA footage.

In the live video, relayed by the American space agency, the UFOs move from the right of the screen towards the left. After they were seen conspiracy theorists claimed the live feed was cut.

Last year it was also suggested that a "nervous" astronaut was telling ground control about the appearance of a strange red-coloured UFO on the live NASA feed.

They claim he said the word "gospel" when the object appeared, and suggested this may have been a codeword as ground control replied "we pray for you."

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Crystals grown aboard space station provide radiation detecting … – Phys.Org

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April 20, 2017 by Jenny Howard The Solidification Using a Baffle in Sealed Ampoules (SUBSA) hardware being installed by NASA astronaut Peggy Whitson during Expedition 5. The SUBSA Furnace and Inserts investigation includes modernized data acquisition, high definition video and communication interfaces. Credit: NASA

Research into crystal growth in microgravity was one of the earliest investigations conducted aboard the International Space Station and is continued to this day. The unique microgravity environment of space provides an ideal setting for producing crystals that are more perfect than their terrestrial-grown counterparts. The Crystal Growth of Cs2LiYCl6:Ce Scintillators in Microgravity (CLYC-Crystal Growth), a Center for the Advancement of Science in Space (CASIS)-sponsored investigation, will study the potential benefits of growing the CYLC crystal in microgravity.

The CLYC crystal is a special kind of multicomponent crystal system used to make scintillator radiation detectors, a device that is sensitive to both gamma rays and neutrons.

"It's a spectroscopic crystal, which means, using this crystal, we can detect the presence and intensity of radiation, as well as identify which isotopes emit radiation by measuring the energy," said Dr. Alexei Churilov, primary investigator and senior scientist at Radiation Monitoring Devices Inc. (RMD).

The CLYC crystal is produced as a commercial product by RMD and is largely used to detect and differentiate both harmful and harmless levels of radiation. The crystal's main application is homeland security as a method of detected smuggled nuclear materials, but may also be used for oil and gas exploration, medical imaging, particle and space physics and scientific instruments.

However, the Earth-grown crystals have shown defects such as cracks, grain boundaries and inclusions, incidents which scientists like Churilov hope to eliminate by using the space station's microgravity environment as a growth habitat.

Research has shown that many, though not all, crystals benefit from growth in microgravity. Although the reasoning behind this phenomena is still being investigated, research points to the lack of buoyancy-induced convection, which affects transport of molecules in the crystal.

"Our ultimate goal is to study the growth of CLYC in microgravity without the interference of convection and to improve the production of the crystal on Earth," said Churilov.

The research for the CLYC Crystal Growth investigation will be conducted within the Solidification Using a Baffle in Sealed Ampoules Furnaces and Inserts (SUBSA Furnaces and Inserts). SUBSA helps researchers advance the understanding of processes involved in semiconductor crystal growth. It offers a gradient freeze furnace for materials science investigations. SUBSA was originally operated aboard the space station in 2002, the SUBSA hardware has been modernized and updated with data acquisition, high resolution video and communication interfaces.

During the investigation, four crystal growth runs will be conducted aboard the space station and then in the ground-based SUBSA furnaces, giving researchers a view into the gravitational effect on their growth. Once the investigation is complete, the space-grown crystals will be compared against their counterparts on Earth and tested for imperfections and effectiveness as radiation detectors.

Although microgravity can't be mimicked or reproduced on the ground, results from the investigation will provide information about which crystal methods to use on Earth, how to improve ampoule and furnace design and which crystal growth parameters to change in pursuit of a more perfect crystallization process.

Though the total weight of the CLYC Crystal Growth investigation is small, only a few kilograms together with packaging, the benefits can be immense as the data gathered during the investigation will be put to immediate use in the production of CLYC crystals.

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Explore further: Space station crew cultivates crystals for drug development

Crew members aboard the International Space Station will begin conducting research this week to improve the way we grow crystals on Earth. The information gained from the experiments could speed up the process for drug development, ...

Orbital ATK is targeted to launch its Cygnus spacecraft into orbit for a resupply mission to the International Space Station March 24, 2017 from Cape Canaveral Air Force Station in Florida. Cygnus will launch atop a United ...

In the microgravity experiments at the International Space Station (ISS), scientists revealed that supercooled water containing antifreeze glycoproteins accelerates and oscillates its ice crystal growth rate. This seemingly ...

An experiment led by the University of Colorado Boulder arrived at the International Space Station today and will look into the fluid dynamics of liquid crystals that may lead to benefits both on Earth and in space.

Twinning is a crystal-growth disorder in which the specimen is composed of distinct domains whose orientations differ but are related in a particular, well-defined way. Twinning, which is a known problem in protein crystallography, ...

Crystals that don't experience mechanical stress during growth have superior quality. Levitating liquid metal is the idea behind the project 'Perfecting metal crystals' led by the University of Twente in the Netherlands.

Physicists at the Institute for Quantum Information and Matter at Caltech have discovered the first three-dimensional quantum liquid crystala new state of matter that may have applications in ultrafast quantum computers ...

Getting something from nothing sounds like a good deal, so for years scientists have been trying to exploit the tiny amount of energy that arises when objects are brought very close together. It's a source of energy so obscure ...

(Phys.org)A team of researchers at Karlsruhe Institute of Technology in Germany has developed a way to 3-D print objects made of pure glass. In their paper published in the journal Nature, the group describes their technique ...

A research team led by UCLA electrical engineers has developed a new technique to control the polarization state of a laser that could lead to a new class of powerful, high-quality lasers for use in medical imaging, chemical ...

Materials science researchers have developed a model that can account for irregularities in how atoms arrange themselves at the so-called "grain boundaries" - the interface where two materials meet. By describing the packing ...

Researchers have developed a new solution to tracking objects hidden behind scattering media by analyzing the fluctuations in optical "noise" created by their movement. In The Optical Society's journal for high impact research, ...

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Mars colony could 3D-print stuff from Red Planet dust – CBS News

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A new method has used simulated Martian and lunar dust to 3D print flexible, tough rubber tools like these.

Amanda Morris

A new technique could allow the first humans on Mars to 3D print everything from tools to temporary housing out of a tough rubber-like material using only Martian dust.

The method could enable the first humans who set foot on the Red Planet to print the tools and housing they need to survive without having to lug all the supplies aboard their spaceship.

For places like other planets and moons, where resources are limited, people would need to use what is available on that planet in order to live, Ramille Shah, a materials scientist at Northwestern University in Illinois,said in a statement. Our 3D paints really open up the ability to print different functional or structural objects to make habitats beyond Earth. [Sending Humans to Mars: 8 Steps to Red Planet Colonization]

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NASA has big plans for Martian exploration with Mars 2020. Only on CBS This Morning, Jan Crawford take a behind-the-scenes look at the assembly...

Any trip to Mars would requirespaceshipsbig enough to carry much more fuel and supplies than past spacecraft could, but care packages from Mother Earth wont be enough for humans to make it on an alien planet. Almost all schemes for colonizing the Red Planet (or for colonizing the moon) require that at least some of the supplies for the expeditions come from the local environment.

One step toward that goal would be to develop a super tool that could be used to quickly manufacture any other desired tool or object, using local resources. To that end, Shah and her colleagues wanted to see what could be made with some of the most abundant material on Mars and the moon: dust. The researchers used simulated dusts based on real lunar and Martian samples. The synthetic dust contains mixtures of aluminum oxide, silicon dioxide, iron oxide and other compounds. The hard particles simulating the lunar surface often have jagged, sharp edges, while Martian simulated dust is made up of rounder, less irregular particles, according to the researchers.

The team developed a process that combines simulated lunar andMartian dustwith solvents and a biopolymer to create these extraterrestrial inks. The inks were then 3D printed into different shapes using an extruder. In the end, the objects which were composed of about 90 percent dust were tough and flexible, and could withstand the rolling, cutting and folding needed to print almost any 3D shape, Shah and her colleagues reported online March 20 in the journalScientific Reports.

We even 3D-printed interlocking bricks,similar to Legos, that can be used as building blocks, Shah said.

While rubbery materials could have their uses, as a next step, Shah and her colleague David Dunand, a materials scientist at Northwestern University, are now trying to figure out ways to heat these rubbery polymers so they harden like ceramics.

Originally published onLive Science.

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Apparently the Trump Administration Is Interested in Monetizing the Moon – Men’s Journal

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Its been bad news for the funding of many federal agencies since Donald Trump took office, but one of the bright spots in the gray new Washington cloud settled overhead is that NASAs budget escaped comparably intact, suffering only cuts to climate change research. As David Axe reported for Motherboard, Where Trump wants to reduce the EPAs funding by a third, effectively gutting the agency, he's proposing a mere $200 million reduction to the National Aeronautics and Space Administration's current $19.3 billion budget.

A new report points that the Trump administration is leaving NASA intact because it believes it has significant potential to make money.

Thanks to internal communications between NASA and Trumps space transition team... we have some clues as to why Trump seems determined to keep the space agency mostly intact, writes Axe. The administration seems to be very interested in NASA's moneymaking potential.

As far as the Trump Administration is concerned, the money-making value of NASA seems to be tied up in two prominent segments of research and activity: tech development and the moon.

It appears NASA saved their funding by effectively convincing the Trump administration that it was on their side by suggesting that the efforts eventually make it to market, for other sectors to benefit from their work. In a transition memo(scroll down), NASA explains that their funding is split between in-house research efforts and contracting, which private innovation proponents are likely to be happy to hear. NASA further says that once technology reaches maturity, it is often shared with the public. From the memo:

NASA pursues technology development to support both the national innovation system (industry, academia, other government agencies, and the general public) and specific NASA mission requirements As STMD research and technology (R&T) efforts mature, appropriate technologies are transferred to industry and commercialized through multiple programs and approaches to benefit a wide range of users ensuring the nation realizes the full economic value and societal benefit of these innovations.

NASA further clarified that they spread this research "to the broader aerospace community, while protecting our industry partners proprietary interests." In other words, they seek to release everything they can to the public that wont harm a private sector partners proprietary interests.

And while NASA cautions the administration that their primary purpose is academic, they do hint that in the pursuit of the academics, theres something financial to be gained.

Significant portions of the document were dedicated to outlining how and where research was progressing on finding resources on the that would be collectable and, potentially, sustain human life either for the purpose of a mining outpost or maybe colonization one day.

But whether any of that collection could one day make money is an international law question. To extract valuable resources from the Moon for commercial purposes would seem to at least bump up against the 1967 Outer Space Treaty signed by the United States, Russia (then USSR), and 90 other countries, Motherboard explains. The document states: "The exploration and use of outer space, including the Moon and other celestial bodies, shall be carried out for the benefit and in the interests of all countries, irrespective of their degree of economic or scientific development, and shall be the province of all mankind."

So perhaps those moon mining dreams are dead in the water, as the president would never want to violate international law for profit.

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Extension to host seminar on GMOs – messenger-inquirer

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Fourth-graders might be on to something.

Once, during a school presentation, Paul Vincelli asked a group of students what they would do with genetic engineering.

One said he'd make broccoli taste like chocolate. Another said she'd make some foods more nutritious for poor people.

"They've got the right idea," he said with a laugh. "I tell audiences (genetic engineering) is like copying and pasting a sentence in a document on your computer."

But Vincelli, Extension professor of plant pathology at the University of Kentucky College of Agriculture, doesn't try to convince anyone to be in for or against genetic engineering he just presents the facts.

He'll do so at the Food Myths and Misconceptions seminar and Q&A at 6 p.m. Tuesday and at noon Wednesday in the Advanced Technology Center's Chandler Conference Room at Owensboro Community and Technical College, 4800 New Hartford Road. It is presented by the Daviess County Cooperative Extension Service.

Vincelli's presentation will cover the scientific aspects of genetic engineering in foods genetically modified organisms, or GMOs that is, the process of introducing new DNA to a plant or animal to alter its genome. Newer technology allows genome editing, a more precise method that can add, remove or substitute specific traits and target specific locations within the genome.

"GMO science is a very broad topic of study," Vincelli said during a phone interview from Fresno, California. He was there to present to the U.S. Department of Agriculture and California State University. He is also published in research journals.

"There are multiple and complex factors, but I like to focus on what we do and don't know about GMOs, and the risks and benefits."

A recent good example of GMO science, he said, lies in East Africa, where the woody root cassava is a foundational part of the diet. When a virus called brown streak disease threatened the food supply, modifying cassava to be disease-resistant was the answer.

Last May, the National Academies of Sciences, Engineering and Medicine released a report stating while genetic alteration can have unintended consequences, their review of about 900 studies and years of disease data shows no increase in health risks due to the consumption of GMOs.

Many non-GMO advocates, though, suggest GMOs pose environmental, human health and economic problems. Theres an ongoing debate among science experts on whether or not glyphosate is linked to cancer, the report states. The herbicide is often used with GMOs and was made popular when patented in the 1970s and sold as Roundup by the agricultural biotechnology corporation Monsanto.

Its widespread use might have weakened its ability to control weeds, which led Monsanto to create Roundup Ready soybean seeds in 1996, followed by corn. Roundup Ready crops are resistant to herbicides, thus farmers can spray for weeds without damaging their crops.

I always say it's not a sustainable weed control approach, but theres a lot of interest in the food system among urban and suburban audiences, and theres much more to it than Roundup Ready, Vincelli said.

"People would like to know what science says about all of these things, so well take a critical look the research and I think we'll have a rich discussion," he said. "I aim to be fair to all sides and just tell it like I see it.

Angela Oliver, 270-691-7360, aoliver@messenger-inquirer.com

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Disease-associated genes routinely missed in some genetic studies … – Penn State News

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UNIVERSITY PARK, Pa. Whole-exome DNA sequencing a technology that saves time and money by sequencing only protein-coding regions and not the entire genome may routinely miss detecting some genetic variations associated with disease, according to Penn State researchers who have developed new ways to identify such omissions.

Whole-exome sequencing has been used in many studies to identify genes associated with disease, and by clinical labs to diagnose patients with genetic disorders. However, the new research shows that these studies may routinely miss mutations in a subset of disease-causing genes associated with leukemia, psoriasis, heart failure and others that occur in regions of the genome that are read less often by the cost-saving technology. A paper describing the research appeared online April 13 in the journal Scientific Reports.

Although it was known that coverage the average number of times a given piece of DNA is read during sequencing could be uneven in whole-exome sequencing, our new methods are the first to really quantify this, said Santhosh Girirajan, assistant professor of biochemistry and molecular biology and of anthropology at Penn State and an author of the paper. Adequate coverage often as many as 70 or more reads for each piece of DNA increases our confidence that the sequence is accurate, and without it, it is nearly impossible to make confident predictions about the relationship between a mutation in a gene and a disease. In our study, we found 832 genes that have systematically low coverage across three different sequencing platforms, meaning that these genes would be missed in disease studies.

The researchers developed two different methods to identify low-coverage regions in whole-exome sequence data. The first method identifies regions with inconsistent coverage compared to other regions in the genome from multiple samples. The second method calculates the number of low-coverage regions among different samples in the same study. They have packaged both methods into an open-source software for other researchers to use.

Even when the average coverage in a whole-exome sequencing study was high, some regions appeared to have systematically low-coverage, said Qingyu Wang, a graduate student at Penn State at the time of the research and the first author of the paper.

Low-coverage regions may result from limited precision in whole-exome sequencing technologies due to certain genomic features. Highly-repetitive stretches of DNA regions of the genome where the same simple sequence of As, Ts, Cs and Gs can be repeated many times can prevent the sequencer from reading the DNA properly. Indeed, the study showed that at least 60 percent of low-coverage genes occur near DNA repeats. As an example, the gene MAST4 contains a repeated sequence element that leads to a three-fold reduction in coverage compared to non-repeating sequences. Even when other genes have sufficient coverage, this region of the MAST4 gene falls well below the recommended coverage to detect genetic variations in these studies.

One solution to this problem is for researchers to use whole-genome sequencing, which examines all base pairs of DNA instead of just the regions that contain genes, said Girirajan. Our study found that whole-genome data had significantly fewer low-coverage genes than whole-exome data, and its coverage is more uniformly distributed across all parts of the genome. However, the costs of whole-exome sequencing are still significantly lower than whole-genome sequencing. Until the costs of whole-genome sequencing is no longer a barrier, human genetics researchers should be aware of these limitations in whole-exome sequencing technologies.

In addition to Girirajan and Wang, the research team at Penn State includes Matthew Jensen, graduate student; Naomi S. Altman, professor of statistics; and Cooduvalli Shashikant, professor of molecular and developmental biology, all of whom are also members of the Penn State Huck Institutes of the Life Sciences Bioinformatics and Genomics Program. The work was funded by the March of Dimes Foundation, the U.S. National Institutes of Health, the Brain and Behavior Research Foundation, the Huck Institutes of the Life Sciences, and the Penn State Experiment Station.

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Two UChicago Medical Studies Among 2016’s Best Research Papers – The Chicago Maroon

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Two University of Chicago Medicineled studies were selected by the Clinical Research (CR) Forum as among the top three best clinical research papers of 2016.

CR Forum is a national organization of senior researchers and leaders in clinical thought from leading academic health centers, pharmaceutical firms, information technology, and nonprofits.

The Herbert Pardes Clinical Research Excellence Award is the CR Forums highest honor, and comes with a $5,000 cash prize. This year, it was awarded to geneticist Carole Ober, Ph.D., University chairman and professor of human genetics, and immunologist Anne Sperling, Ph.D., University associate professor of medicine, for their study, Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children, published August 4, 2016, in the New England Journal of Medicine.

The study examines environmental risk factors for susceptibility to asthma and allergies, comparing two U.S. farming populations: the Amish of Indiana and the Hutterites of South Dakota.

The Distinguished Clinical Research Achievement Awards honor two studies that demonstrate creativity or innovation, and whose works have an immediate impact on the well-being of patients. One of these was granted to University professors Bhakti Patel, M.D., and John P. Kress, M.D., for their study titled Effect of Noninvasive Ventilation Delivered by Helmet vs. Face Mask on the Rate of Endotracheal Intubation in Patients with Acute Respiratory Distress Syndrome.

The study found that helmet ventilation, as opposed to a traditional face mask, dramatically reduced the chances of patients needing a tube ventilator, and made patients 20 percent more likely to survive Acute Respiratory Distress Syndrome.

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Genetic testing could hold the key to reduce adverse events in heart stent implantation – ETHealthworld.com

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by Amrita Surendranath, Masters in Human Genetics, Xcode Life Sciences

In 2010, the US Food and Drug Administration (FDA) issued a warning on the box of the anti-clotting drug Clopidogrel that patients who do not metabolize the drug will not receive the full benefits of the drug. This, in essence, is a landmark that highlights the importance of personalized care in the emerging field of precision medicine. In retrospect, Clopidrogels failure among certain patients hardly seems surprising: patients are genetically diverse, and such variation affects patients response to particular therapies. Roughly 75% of the U.S. population does not metabolize medications normally and 2.2 million severe Adverse Drug Events (ADEs) occur in the U.S. every year. Genetics can account for 20-95% of the variability in an individuals response to drugs. Medicare fined three-quarters of eligible hospitals for re-admissions in 2014. Current FDA guidance recommends that Drug-gene interactions should be considered similar in scope to drug-drug interactions. Precision medicine takes advantage of the genetic diversity that exists to tailor treatments to those patients who are most likely to respond.

Clopidogrel is a widely used anti-clotting drug and according to Dr. P. Manokar, MD, DM, Professor of Cardiology, Sri Ramachandra University Clopidogrel is like a panacea of all cardiac and vascular diseases from Stroke prevention to Peripheral artery disease to coronary Interventions. It is the essence of pharmacotherapy for all Vascular Disease Scenarios. When the outcomes of treatment are poor, it could prompt some patients from taking the treatment while the condition being treated could turn worse, wasting precious time, effort and money.

Dr. Abraham Ooman, a leading Cardiologist, has also shown interest in genetic testing, stating that here is a need for genetic testing to determine the response to Clopidogrel, especially during high risk cardiac interventions like left main stenting, however, he adds a quick note of caution, but clinical studies are unclear about how effective the current methods are. When the approach to care is evidence based instead of resorting to a trial and error method of prescribing medications, it could help avoid side effects associated with drug use and could, possibly, lower health care costs. In recognition of the promise shown by precision medicine, Ex-President of the United States, Barack Obama, in 2015, announced a nationwide research called the Precision Medicine Initiative for conditions associated with cardiovascular disease, neurodegenerative disease, cancer and autoimmune disorders. In Obamas words, most medical treatments have been designed for the average patient, treatments can be very successful for some patients but not for others.

Though there have been considerable strides in the treatment of cardiovascular disease, cardiovascular disease related death is still one of the most common cause of death. This creates a need to utilize precision medicine to identify patients who would benefit from the treatment provided. As Dr. Manokar says It is very difficult to predict who responds to clopidogrel unless you have an event as a consequence of clopidogrel resistance. You begin a search with your backs to the wall situation. Testing would allay the anxiety of the Doctor and the patient equally

The importance of testing for responders, however, lies in the options that are available, as Dr. Manokar says, The other treatment options are tricky. They come with a whole bag of indications and contraindications which make the options difficult to choose. Both Ticagelor and Prasugrel are niche molecules but need huge brainstorming before choosing as an alternative to Clopidogrel. The enthusiasm shared by doctors and the regulators are shared by drug companies too with 28 percent of drugs that were approved by the FDA in 2015, considered to be precision medicine based therapies.

The concept of genetic testing is not new and is an essential medical tool that has been used by the medical community for decades to look deeper into the human body for myriad determinations. Chromosomes are investigated for carrier testing, newborn screening, prenatal diagnosis, diagnostic testing, paternity, genealogy and forensics testing. So, testing for responders is a natural progression and Testing is always cost effective. It offers intangible benefits in terms of allaying anxiety, long term outcomes, more than the tangible benefits in terms of choice of drugs and duration of therapy, said Dr. Manokar. Though, he further stated that the additional cost is an important determinant of the number of patients that we would test routinely. It is important also with respect to Ticagelor switch since it is the most expensive drug in this group.

Clinically, the use of pharmacogenetics could potentially include vast areas like new drug development, drug discovery research, the genetic testing of patients and clinical patient management. The ultimate aim of pharmacogenetics is to predict genetic response of patients to a specific drug to deliver the best possible medical treatment. By predicting the drug response of an individual, it will be possible to increase the success of therapies and reduce the incidence of adverse side effects. Personalized medicine is the logical way forward, however, it should pass the necessary scientific scrutiny of clinical trials, said Dr. Abraham stressing the need to accept this aspect of medical science as the way ahead.

A single method of treatment for everyone is unrealistic in the current understanding of medical science because of the complex interplay between genes, cell metabolism, proteins and environmental influences. As Dr. Manokar puts it, future of pharmacology is going to be pharmacogenomics. Patient centric medicine and genome tailored pharmacotherapy will be the norm rather than the exception.

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Arkansas Fights to Execute Two Men Without Testing DNA Evidence That Could Exonerate Them – The Intercept

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Damien Echols neverplanned to come back to Arkansas. These days, I try to look forward, he wrote in his 2012 memoir, Life After Death.Im tired of looking back. After spending half his life on Arkansass death row he was finally released in 2011 Echols was sick to death of his claim to fame as one of the West Memphis Three. Its a title Id prefer never to hear again, he wrote. It does nothing but remind me of hell.

Echols was wrongfullyaccusedof murdering three 8-year-old boys whose bodies were discovered in the woods in rural Arkansas in 1993. It was the tail end of a bizarre era in American criminal justice, a wave of public hysteria known as thesatanic ritualabuse panic, in which numerous people were wrongly sent to prison for lurid and in some casesnonexistent crimes against children. Echols, who grew up as a misfit in his small Arkansas town, was accusedof being amember of a satanic cult, based on such proof as the fact that helistened to heavy metal, along with the coerced confession of one of his teenage co-defendents, who was mentally disabled.The case inspired multiple documentaries, which transformed Echolss plight into a cause clbre. Hewas grateful for the support, but even on death row the attention eventually took a toll. My entire life had been exposed for anyone and everyone to examine, he wrote. Every day I received letters from people who did nothing but ask the most intimate aspects of my life. There was one letter, though, that disarmed Echols, from a woman who apologized for invading my privacy by seeking me out. That woman, Lorri Davis, later became his wife.

Today Echols lives in New York City, a place that giveshimthe gift of anonymity. But on Friday, April 14, Echols stood on the steps of the Arkansas State Capitol, with Lorriby his side. It was the first time that Echols had returned to the statewhere he was supposed to be executed, a place that filled him with fear. But he felt he had no choice: After nearly 12 years without an execution in the state, in late February Gov. Asa Hutchinson had signed death warrants for eight men, who were to die in pairs on four separate nights before the states supply of a key drug it planned to use as part of its lethal injection cocktail passed its expiration date. These were men Echols had lived with for almost 20 years. When the Arkansas Coalition to Abolish the Death Penalty invited him to speak at a rally at the Capitol, planned for Good Friday, he struggled. My first thought was I cant. I cant do this, he told reporters. But he knew that if he did nothing, I would haveto live the rest of my life knowing that I didnt raise a hand to help these people.

Former Arkansas death row inmate Damien Echols, center, back to camera, speaks at a rally opposing the states upcoming executions, on the front steps of Arkansass Capitol, April 14, 2017, in Little Rock.

Photo: Stephen B. Thornton/The Arkansas Democrat-Gazette/AP

Pale and tattooed up to his neck, Echols wore a black sleeveless shirt, a black Yankees cap, and sunglasses, which he wears around the clock. Echols spent much of his last decade of incarceration insolitary confinement, which he says destroyed his eyesight, making him acutely sensitive to light. Standing to the side as the rally kicked off, a huddle of press and onlookers crowded around Echols, shoving microphones and cameras in his face and snapping photos of the actor Johnny Depp, a longtime friend and supporter who showed up with him. In the two days before he arrived in Little Rock, Echols told reporters, hed slept no more than an hour. He was constantly on the verge of a panic attack, unable to breath, just realizing that Im about to come back here, where they tried to kill me.

The afternoon was hot and muggy. Volunteers in blue T-shirts handed out water bottles. Some held signs over their heads to block the sun. In the crowd, a woman held a posterboard quoting former Arkansas Gov.Winthrop Rockefeller, who once commuted the sentences of every man on death row, saying, What earthly mortal has the omnipotence to say who among us shall live and who shall die? Another sign read Governor Hutchinson: Dont Do This.

At the podium, Rizelle Aaron, president of the Arkansas State Conference of the NAACP, decriedthe hypocrisy of Bible-thumping officials who call themselves pro-life.We allow politicians to come into our churches for an opportunity to profess their faith and commitment to God in the hopes of gaining our votes, he said. They quote scripture from our pulpits andmany of them honor God with their mouths. But their hearts are far from God.Waiting for Echols to speak, a 19-year-old woman named Drew, from Fort Smith, Arkansas, held a sign with his name and a heart underneath. Today she is just one year older than Echols was when he was arrested. I was young at the time, but I definitely remember [the case], she said, recounting the details. Echols and his co-defendants were targeted because they were outcasts, she said, calling Echols a living testament to why the death penalty is so wrong.

Taking the mic, Echols described his fear upon returning to Arkansas and his disgust at the bureaucratic labyrinthof corruptionthat passes for a justice system here. Even after DNA evidence was found to exclude him and his co-defendants, Echolssaid, they still kept trying to kill me, keeping him on death row for two more years.

After the rally, a group of activists and reporters entered the Capitolto deliver boxes of petitions to Hutchinsons office 157,593 signatures,to be exact. Furonda Brasfield, head of the Arkansas Coalition to Abolish the Death Penalty, gave the governors spokesperson, J.R. Davis, a copy of Echolss book. And Paris Powell, an exoneree from Oklahoma a state notorious forsloppyattempts to push through questionable executions told Davishe spent many years on death row as an innocent man. I came to this state just for this reason, he said.

But the governor remained unmoved. Lawyers for the state spent Easter weekend scrambling to respond to subsequentlegal rulings blocking his execution plans. On Easter Sunday, Davistook to Twitterto bickerwith famed anti-death penalty nun Sister Helen Prejean, who has been relentlessly critical of his boss.Nonetheless, by the night of Monday, April 17, a stay of execution was in place for Bruce Ward, who had been set to die that evening. Don Davis was not as lucky. He had already been moved to a cell adjacent to the death chamber at the Cummins Unit, some 80 miles southeast of Little Rock.

Echols was back in New York on Mondayknight, posting on Twitter and Facebook. In interviews, Echols repeatedly described how Don Davis, who was tormented by the crime he committed, brought him food and watched his back. Without the following people I wouldnt be here today, Echols writes in the acknowledgment pages of his book, listing a handful of fellow death row prisoners. Davis is included, along with Marcel Williams, who faces execution on April 24.

J.R. Davis, spokesperson for Arkansas Gov. Asa Hutchinson, speaks after the news that the U.S. Supreme Court stayed the scheduled April 17, 2017, execution of Don Davis.

Photo: John L. Mone/AP

The plan to killDavis became embroiled in chaos and confusion.After the Arkansas Supreme Court ordereda temporary restraining order earlier that day, hislawyer released a statement celebrating the fact that there would be no executions tonight. But state Attorney General Lesley Rutledge immediately askedthe U.S. Supreme Court to vacate the stay, ushering in a new round of dread and anticipation.The death warrant for Davis expired at 11:59 Central time. Outside the prison, activists waited for news. As Davis waited to learn whether he would live or die, reporters tweeted about his last meal fried chicken, strawberry cake while noting that the state appeared to be operating on the assumption it would kill him. Just after 11 p.m., J.R. Davistold reporters they were moving witnesses into place, despite the fact that the U.S. Supreme Court had not yet ruled.

On Twitter, Echols called Arkansas politicians bloodthirsty. He retweeted longtime Arkansas journalist John Brummett, who wrote, Ive never seen such a powerful official hankering to kill and kill now as is being seen in Arkansas political leadership tonight. But officialsfailed in the end. Just beforemidnight, the U.S. Supreme Court ruled against the state of Arkansas, keeping the temporary stay in place. No one would die in the execution chamber that night.

ACLU of Arkansas Executive Director Rita Sklar and others prepare to carry boxes containing petitions to Gov. Asa Hutchinsons office, asking him to stay upcoming executions, April 14, 2017, in Little Rock, Ark.

Photo: Stephen B. Thornton/The Arkansas Democrat-Gazette/AP

The state of Arkansashas not given up its execution plans. But every day they seem to unravel a little more. Tonight, onApril 20, officials planned to killStacey Johnson and Ledell Lee,both of whom insist they are innocent. But late Wednesday afternoon, a circuit court judge imposed a temporary restraining order on the states planned use of vecuronium bromide, the second in Arkansass highly contested three-drug protocol. The provider of the drug, a pharmaceutical company called the McKesson Corporation, accused officialsof misleading the company when it sought out the supply, concealing their intention to use it for executions.

The ruling put allexecutions on hold. Shortly afterward, a second ruling, by theArkansas Supreme Court, granted a stay to Johnson, withlawyers for the Innocence Project successfully arguing thatJohnson has the right to an evidentiary hearing in order to make thecase for DNA testing. Lee, too, has the Innocence Project on his side, as well as lawyers with the ACLU. He, too, has fought forDNA testing, to no avail.

The cases of Johnson and Lee add yet another dimension to a system of capital punishment that has been exposed, again, to be profoundly and frighteninglyflawed. Beyond the immediate chaos and legal wrangling sparked by Hutchinsonsplanned killing spree, the cases of the eight men he originally set to die haveexposed themanyuglysides of thedeath penalty in Arkansas, from themental illnessthat pervades death row, to the failures of the clemency process, to a history of botched executions and experimental killing protocols disguised as science. It was only a matter of time, since the risk of executing an innocent person was sure to come up. When youre carrying out mass executions, its inevitable that innocent people are going to get caught in that net, Echolstweeted on Wednesday.

Innocentor not,Lee and Johnson also represent a legacy of reserving the harshest punishments forblack men accused of crimes against white women. Both wereconvicted of raping and murderingyoung white women in their 20s. Both crimes date back to the early 1990s, and both men were tried twice,in an era when Arkansas defense attorneys were woefully ill-equipped to represent defendants facing the death penalty. In 1990, the Arkansas Gazette surveyed 22 local trial lawyers, finding that half had no capital-murder experience before they were appointed to cases that eventually put their clients on death row.

In Lees case, the records show shocking failures of his defense attorneys, both at trial and post-conviction, which were compounded byegregious conflicts of interest. His trial judge was having an affair with the prosecutor;the two would later get married. The same judge later expressed his regret at appointing a lawyer to Lees state habeas proceeding who showed up to court obviously intoxicated. A state prosecutor raised concerns that the attorneywas slurring his words, stumbling in the courtroom, and speakingincoherently, whileintroducing the same items of evidence over and over again. Later, the judge told the lawyerthat he was unaware he had only recently been inrehab.If I had known that, I would not have put you on this case, he said.

Lee was convicted of murdering and sexually assaulting 26-year-old Debra Reese in 1993. Strangled and beaten to death in her homein Jacksonville, Arkansas, Reese was struck36 times with atire thumper, which her husband, a truck driver, had given to her for protection when he was on the road, according to court records. Lee was arrested the same day. The states theory, as summarized by the Arkansas Supreme Court, was that Leehad set out to commit a robbery andsearched the victims neighborhood until he found the perfect target for his crime.

Yet despite ample blood and fingerprints at the scene,virtually no physical evidence was found to match Lee. The case against him relied on eyewitness testimony now known to be notoriously unreliable along with two main piecesof forensic evidence. One was an apparent blood spot found on a pair of Converse sneakers Leewas wearing at the time of his arrest. According to the Arkansas Supreme Court, astate serologist confirmed the presence of blood, but consumed the entire sample, thus removing the opportunity for independent analysis by the defense. The second piece of evidence wasa hair sample thought to come from a black man and found to be consistent with Lees based on microscopic examination a forensic method that has since been discredited, according to the Innocence Project.

Lawyers this week sought a stay of execution from the Arkansas Supreme Court,arguing that the Converse sneakersandhair fibers should be subject to DNA testing, which has advanced by leaps and bounds since the 1990s. But their argument was rejected. With Leesexecution appearing imminent on Wednesday, attorneys moved to introduce evidence to the Arkansas Board of Parole that Lee suffers frombrain damage and significant intellectual disability, which was never properly presented by previous attorneys. Instead, thetemporary restraining order overthe lethal injection drug is keeping Arkansasfrom taking his life.

Protesters rally against Arkansass planned execution spree.

Photo: Kristin L. P. Pearson

Johnson was convicted twice, in 1994 and 1997, of raping and murdering 25-year-old Carol Jean Heath, in DeQueen, Arkansas. Her body was discovered at her home by a friend, Rose Cassady, in the early morning hours of April 2, 1993. Heath was in a pool of blood, naked exceptfor a T-shirt. Her throat had been deeply cut. After calling the police, Cassady realized Heaths two young children were at the house. According to Cassady, Heaths 6-year-old daughter, Ashley, said, A black man broke in last night.

A police officer interviewed Ashley later that day. She told him that she had been sitting on the couch with her mother when someone knocked on the door. It was a black male, Ashley allegedly said, describing later how the two fought, while she and her 2-year-old brother, Jonathan, hid in the closet.

Johnson did not live in Arkansas at the time, but had returnedto DeQueen to attendhis fathers funeral. Although he was accused of sexual assault, no semen or other such evidence was found at the scene. As with Lee,the primary forensicevidence against Johnson wasa negroid hair. It was tested for DNA, with results that could not excludeJohnson. Attorneys unsuccessfully argued that he had a consensual relationship with Heath. Whilewitnesses conceded that Johnson had been at Heaths home more than once before the crime, at his 1997 retrial, three witnesses strenuously stated that Ms. Heath had not had a relationship with a black man, according to a recent appeal.

At his clemency hearing in late March, Johnson argued that his conviction was rooted in racism, which ledthe state to overlook other leads. There was a lot of evidence that could have shown that it wasnt me, but they ignored it, he told members of the parole board. They just looked at me, they found the big black guy and the little white person that was a victim and that was enough that they needed.

As in Lees case, the Innocence Project points to several untested pieces of evidence that could have significant probative value as well as major scientificadvances that could yield more accurate forensic results than possible in the 1990s. While hairs thought to belong to a white person were found at the scene,those were never tested. The evidence isimportant in addressing an alternate theory of the crime.Johnsons attorneys unsuccessfully pointed to Heaths boyfriend at the time, a white man named Branson Ramsey, who had a history of abuse. At Johnsons 1997 retrial, Ramseys ex-wife testified that her husbandwould punch me or slap me or kick me or bite me. Particularly notable was her claim thathe bit her on my breast. Heath, too, had apparent bite marks on her breasts. Ramsey died in 1998. In response to Johnsons motion for DNA testing last week, the statedismissed the strategy as a classic case of blame-the-dead-guy.

But putting aside the DNA evidence, perhaps the biggest red flag in the case was the states reliance on Heaths traumatized young daughter, Ashley. Though she wasfound incompetent to testify at Johnsons first trial, in 1994, Ashleywas deemed ready to take the stand for the retrial in 1997. The 10-year-old delivered testimony thatseemed heavily influenced by relatives and prosecutors a fact that alarmed members of the Arkansas Supreme Court who reviewed the case years later. In a 4-3 ruling leaving the conviction intact, the dissenting judges noted that Johnsons defense attorneys had been denied access totherapist records that showed Ashleys stories were profoundly inconsistent and that she had been under considerable pressure from her family and the prosecutor to convict Stacey Johnson. Among passagesthey quoted: The DA says shes the only one who can keep him behind bars; Her grandmother told Ashley that she has to keep him behind bars, because if he gets out hell try to kill Ashley next.

Ashley Heath is now in her 40s.In 2015, the last time Johnson was up for execution, she told the parole board thatshe no longerbelieves the death penalty brings justice.I am tired of re-living [the crime], she said. I am ready to put it behind me and move on with my life.

The sun sets over an Arkansas State Police command post outside the Varner Unit of the Arkansas Department of Correction near Varner, Ark., on Monday evening, April 17, 2017.

Photo: Stephen B. Thornton/The Arkansas Democrat-Gazette/AP

On Tuesday, April 18, two days before Lee and Johnson were set to be executed, a black man in Louisiana was officially exonerated.Rodricus Crawford was sent to death row in 2013 by Caddo Parish District Attorney Dale Cox, who later made headlines forsaying thatdeclining death sentences around the country were a bad sign. I think we need to kill more people, he said. Like Hutchison, who is fond of tweeting Bible verses on Sunday, Cox likes to invoke theBible. InCrawfords case, he insistedJesus himself would have supported the death penalty.

Crawford is now the 158th death row exoneree in the country. He isfortunate that the state dropped the charges in his case.Damien Echols was not so lucky. He was only freed after he agreed to take an Alford plea, in which one can plead guilty while maintaining ones innocence. It makes no sense whatsoever, Echols told Amy Goodman of Democracy Now on Monday. The entire reason that it exists is so that the state cant be held responsible for what theyve done to you. As far as Arkansas is concerned, it has never sent an innocent person to death row. The state still maintains that they are infallible, Echols said. Theyve never made a mistake, theyve never killed an innocent person.

Yet one case should still haunt the state. In August 1995, amid loud public outcry, Arkansas executed Barry Lee Fairchild, a black man accused in 1983 of raping and killing 22-year-old Marjorie Greta Mason, who worked as a nurse at Little Rock Air Force Base. It was, at the time, the most publicized and contentious death penalty case in modern Arkansas history, in the words of local columnist John Brummett, who described how, for once, theparole board was deeply divided over whether to recommend clemency for Fairchild. Members ultimately voted 4-2 not to do so, with a seventh member of the board recusing herself because of earlier dealings with the case. Still, she wrote a letter to Gov.Jim Guy Tucker saying there were too many uncertainties about Fairchilds conviction.

The Fairchild case became famous outside Arkansas for embodying the enduring problemswith capital punishment. A black man with IQ scores as low as 60, Fairchildhad been accused of killing a white woman on highly questionable evidence. In an in-depth articlerevisiting the case before his 1995 execution, the Washington Post described how in the absence of forensic evidence, the prosecution case hinged almost completely on Fairchilds videotaped confession. That statement, in which he admitted to being an accomplice to the crime, had been obtainedby a notorious police sheriff named Tommy Robinson, who had a reputation for abuse, as well as for beingopenly, flamboyantly racist. When a state prison refused to help relieve the county jails overcrowding, Robinson, to generate publicity, took a group of his prisoners to the state prison and chained them to a fence, the Post reported.Robinson once was quoted as joking that he treated his black prisoners well, fed them watermelon and chicken, according to the National Journal. With Robinson in charge, a manhunt ensued for the black man who allegedly killedMason.In March 1983, several dozen police officers surrounded the house whereFairchildwas staying. When heemerged, he was attacked by a German Shepherd belonging toRobinson.

Many of the questionsabout Fairchilds guilt emergedafter the conviction, with evidence pointing to his brother as the real perpetrator. Over the phone, the original prosecutor, Chris Raff, who is now retired, recalled thatat the time of the conviction, it was not controversial. Raff did not believe the allegations of Fairchildsmental disability, saying that the facts and players in the case made itgreat fodder for media. But Jeff Rosenzweig, who expresses great respect forRaff, recalls thatlaw enforcement concealed evidence from Raff himself.

Fairchild faced sevenexecution dates before he died. Then-Gov. Bill Clinton setno fewerthan five. At one point, he came within hours of execution, only for a judge to vacate his sentence, based on the conclusion that he never should have been sentenced to die in the first place. Yet Fairchildwould die in the end. His numeroushabeas petitions forestalling his executionlater inspired political efforts to limit the appellate processforpeople on death row. By the timeFairchild was finally executed in 1995, Clinton had been elected president. In 1996, he signed the Antiterrorism and Effective Death Penalty Act, dramaticallycurtailingthe habeas rights of people in prison.

The law has been particularly devastating for those claiming innocence while facing execution, including in Arkansas. Speaking to the board of parole at the clemency hearing for Stacey Johnsonlast month, Rosenzweig tried to explain how AEDPAprevented his client fromgetting his evidence heard. Theextremely tough standard it imposedmeansonly a minuscule percentage of people are able to succeed in federal habeas corpus, he explained. That is why we lost.

With its executionplans increasinglyin doubt, the state of Arkansas remains undeterred and a bitdesperate. In a statement Wednesday evening, Hutchinson said he was surprised and disappointed by the stay imposed by the Arkansas Supreme Court, adding that he would be reviewing his options with Attorney General Leslie Rutledge. In a less measured response, a few hours later a pro-death penalty state senator posted the cellphone number of the chief justice on Twitter.

Throughout it all, Ledell Lee and Stacey Johnson remained in holding cells next to the execution chamber, awaiting the next decision about whether they will live or die. They are still there. In the meantime,Damien Echols continues to speak out,reminding people to stay vigilant. On Thursday, he tweeted: The only reason a judge or politician would not allow DNA testing to be done in a case is because they want to kill no matter what.

Update: April20, 2017: Shortlyafter this story was published, the Arkansas Supreme Court lifted the order blocking the state from usingvecuronium bromide, clearing the way forLedell Lee to be executed tonight.

Top photo: Damien Echols, who was released from death row in 2011, at the Capital Hotel in Little Rock, Ark., April 14, 2017.

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Arkansas Fights to Execute Two Men Without Testing DNA Evidence That Could Exonerate Them - The Intercept

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