Category Archives: Transhuman News

There are many scientists who are pessmistic about how much life extension we can get from new antiaging medicine. The new treatments will be powerful enough to change what all of our DNA is doing. It will be powerful enough to clear out 90-99% of known aging damage. We should be to detect all disease and detect minute levels of damage as it just starts to build up or cause changes in tissue.

How long could we live if we were could just enable people to follow an optimal healthy lifestyle, prevent all preventable diseases, detect all diseases at their earliest stages.

Maintaining a healthy lifestyle, including eating a healthy diet, regular exercise and not smoking, could prolong life expectancy at age 50 by 14 years for women and just over 12 years for men, according to 2018 research in the American Heart Associations journal Circulation. Specifically, they looked at how the following five behaviors affected a persons longevity: not smoking, eating a healthy diet (diet score in the top 40 percent of each cohort), regularly exercising (30+ minutes a day of moderate to vigorous activity), keeping a healthy body weight (18.5-24.9 kg/m), and moderate alcohol consumption (5-15 g/day for women, 5-30 g/day for men).

Longevity is correlated with higher income. We would need to continue the decades long trend of the rest of the world catching up to the USA and Western Europe on per capita income.

The 38,000 people who live in Monaco have a per capita income in 2022 of about 193,000. Half of the live to over the age of 93.

New Jersey has about 850,000 Asians and Asian women in New Jersey live to about the Monaco life expectancy of 93 and Asian men in New Jersey live to an age of about 89.

We either help people to more easily follow these more optimal healthy lifestyles or remove the downsides and impacts from unhealthy behavior.

If we can give everyone the equivalent of optimal human genes then people will be able to live to 105-115. Clint Eastwood, his mother and grandfather all lived into their 90s. Queen Elizabeth and her mother lived or are living to about 100.

People blessed with the right genes live to 110-122 without any mental decline.

There have been features on Korean American women in Bergen County, New Jersey and their healthy lifestyle.

The Brookings Institution, the worlds middle class is growing quickly. 140 million people annually enter the status of middle class. In 5 years, this number can go up to 170 million. The worlds middle class is expected to increase to about 5.2 billion in 2030, or 65% of the planets population then.

The padndemic did stall the trend to a growing global middle class.

There are already some groups of millions of people who have life expectancy of 93-95 years of age. There is no reason that the world cannot have everyone at the per capita income of the current wealthiest countries. Currently 80% of the world has per capita income greater than the wealthiest countries in 1920. The inflation-adjusted highest per capita income in 1920 was about $3300.

There are full body scans that are currently expensive which could be used for consistent early cancer detection. There has even been work at MIT to detect tissue that will become cancerous 5 years before it becomes cancer. Have comprehensive pre-cancer detection is possible. Treating tissue or conditions before they become cancer will have 100% or nearly 100% treatment success.

Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.

Known for identifying cutting edge technologies, he is currently a Co-Founder of a startup and fundraiser for high potential early-stage companies. He is the Head of Research for Allocations for deep technology investments and an Angel Investor at Space Angels.

A frequent speaker at corporations, he has been a TEDx speaker, a Singularity University speaker and guest at numerous interviews for radio and podcasts. He is open to public speaking and advising engagements.

Original post:
Proven Levels of Human Longevity | NextBigFuture.com

The National University Health System (NUHS) establishes the NUHS Centre for Healthy Longevity a world's first integrated pre-clinical and clinical ageing research institute that is poised to lead the Longevity Medicine field with clinical research to prolong healthspan by delay ageing.

SINGAPORE, Sept. 7, 2022 /PRNewswire/ -- Ageing is the climate change in medical science, where global societies are experiencing a sharp rise in the number of older adults relative to the rest of the population. Singapore will be the fastest country by 2025, with 25% of its population estimated to be above 65 years old by 2030. Although medical advancement has improved life expectancy among Singaporeans by 8.7 years to 84.8 years, one of the longest in the world; our healthy life expectancy, or healthspan, increased by only 7.2 years to 74.2 years. The grim reality is that Singaporeans are spending about 10 years of their twilight years in poor health. As the gap between life expectancy and health adjusted life expectancy increases, healthcare and caregiving costs will represent an unsustainable socioeconomic burden for society.

2 NUHS CHL has one clear mission: to enhance healthspan by five years in the Singapore population by slowing biological ageing. Its strategy is to embark on geroscience and longevity medicine-based approaches to achieve this mission. Geroscience and longevity medicine are paradigm-shifting concepts in research and medicine, that acknowledge species-conserved pathways of biological ageing, and view biological ageing as the greatest risk factor for chronic, age-related diseases. Proponents of geroscience/ longevity medicine also advocate the implementation of the use of biomarkers and interventions with the use of artificial intelligence to enhance healthspan.

3 Pre-clinical model organisms have traditionally been used in early pharmaceutical trials, but do not always translate successfully to human trials. NUHS CHL will use age-appropriate models for discovering mechanistic pathways that respond well to novel interventions, called geroprotectors. These treatments will then be translated into clinical human studies of CHL. Both clinical and pre-clinical divisions in the centre work iteratively to identify, refine and implement promising geroprotectors. The South-East Asian population has been traditionally understudied in clinical research. With the three major races, Chinese, Malay and Indian, numbering about 2.5 billion people and accounting for more than a quarter of humanity, results gleaned from the CHL's research will have significant global impact, particularly in Asia.

4 NUHS CHL is also the clinical and translational partner of the Healthy Longevity Translational Research Programme (TRP) at NUS Medicine, whose research to slow ageing, and improve healthspan for the broader population has received generous funding ($5 million) from the Lien Foundation. Termed 'Hacking Ageing', the research initiative comprises three broad themes, which will contribute to the creation of an integrated biomarker-artificial-intelligence (AI) platform that will be the world's first in testing supplements and repurposed drugs combined with lifestyle interventions in the Asian population. This will allow for better early detection, risk stratification and development of personalised, preventive and therapeutic strategies to improve healthspan. Lee Poh Wah, CEO, Lien Foundation said, "Through the 'Hacking Ageing' initiatives, we hope to contribute to the national agenda to shift the healthcare paradigm from the present state of reactive 'sick care' towards a population health prevention approach. Socioeconomic factors are often at the root of health inequalities. As a society, we have a moral duty to ensure anti-ageing therapeutics are not confined to the realm of the rich and exacerbate existing disparities. Developing biomarkers and interventions that are accessible to all in the community, is necessary towards narrowing this gap and democratising healthy longevity. A takeaway from our Gym Tonic programme is that seniors want, and can, get strong on their own terms. Healthspan encompasses not just the physical but the cognitive and emotional dimensions too. We need to mainstream longevity science, and arm everyone with the knowledge and tools to extend the period of life spent in good health."

5 The first research theme funded under the 'Hacking Ageing' initiative is a series of clinical studies to test novel nutritional supplements and repurposed drugs to slow ageing in middle-aged adults (40-60 years). The second research theme is to use deep omics data to personalise these supplements and repurposed drugsand other interventions for optimal healthspan extension in middle-aged participants. The thirdresearch theme focuses on extending healthspan in older adults throughstrength training exercise, harnessing the Foundation's Gym Tonic community of seniors.

6 Professor Brian Keith Kennedy, internationally recognised for his research in the biology of ageing and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human ageing and its associated diseases, is helming the Centre with co-director, Professor Andrea Britta Maier, a geriatrician by training and intensivist of chronic diseases. The 1,600 square feet Centre for Healthy Longevity (CHL) located at Alexandra Hospital and a laboratory at NUSMedicine, will conduct trials and execute validation studies with healthy participants from the age of 30 years old. The Centre will also develop and test these interventions using newly identified biomarkers of human ageing. Once the approaches are validated, the Centre will develop strategies that integrate a combination of nutritional, medicinal and exercise approaches for personalised adoption in the Singapore population. The ultimate goal is to bring the individual closer to his/her state of optimal peak performance during the entire lifespan (e.g. screening to start from 30 years of age).

7 CHL will be looking at blood-based biomarkers, probably the most investigated group due to a large amount of data accumulated in clinical trials.

8 "Developing new interventions to slow ageing and developing new biomarkers to measure ageing, are what we are trying to do here in Singapore through the new Centre," says Prof Kennedy, "and then, we can recommend inventions to see if they can slowly reverse aspects of ageing in the Asian population." Co-director, Professor Andrea Maier added, "The body's ability to fight diseases reduces dramatically with age. If we can address the physiological changes of ageing, we may be able to slow or stop the onset of disease. In three to five years, healthy longevity will not only exist as a lab-proven concept, but will become part of everyone's life."

She elaborated, "The aim of geroscience is to prevent age-related diseases like the occurrence of dementia, cancer, lung diseases, osteoarthritis or sarcopenia, all the diseases we know of. So next time, tell your GP, your biological age, not your chronological age, for a more targeted, customised and precise prognosis and treatment or intervention plan. This also gives the physician a better association with risk of outcomes one will not want to have like impairment and death."

Anyone who is keen to participate in the above various studies can contact [emailprotected] for more information.

SOURCE National University Health System (NUHS)

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Prolonging healthspan by delaying ageing -- NUHS opens Singapore's first Centre for Healthy Longevity to increase healthy lifespan of Singapore...

Its no secret that, on average, building companies last about 5-7 years. So what is the secret to success for home builders that have been in business for 10, 20, or even 30 years? I sat down with Tony Visconti, founder and owner of Bella Custom Homes, and Stacy Brotemarkle, vice president and interior designer, to find out.

A third-generation home builder, Tony has been in the home building and development industry for nearly 46 years. Stacy has been with the team since 2009 yet has more than 20 years of home-building and interior design experience. Although many boast they are the best in the business, the two shared with me a few secrets that they believe are the key ingredients to true success and longevity.

The team at BCH is dedicated to its clients which includes the good, the bad, and the ugly. As a fixed-price builder, Bella Custom Homes clients know their price going into the project. Their clients get a detailed set of specifications with everything going into their new home. This way its not a guessing game. Tony shares that everything is out in the open from the beginning.

If something goes wrong, we own it, Tony says. If they have questions, we tell them the truth. Nothing is sugarcoated.

Stacy adds, Honesty, integrity, and transparency have been the cornerstones of Bella Custom Homes. Those have all contributed to our longevity in the custom luxury home building industry.

This applies to understanding the industry and economics of your business. Tony mentioned that many home builders spread themselves too thin in regards to the timeline of the build cycle.

You dont want to cram your calendar with builds right on top of each other. Spread it out so you have time to build, breathe, and start again. Maybe start out with one a month instead of once a week, Tony adds.

BCH saw the benefits of taking a risk during downturns. While it was low inventory, they saw an opportunity to take a risk and saw the payout in return. However, when facing inflation, it may be a better time to be more risk-averse. Its all about understanding give-and-take and the inner workings of your business.

For Bella Custom Homes, this means using licensed architects, engineers, designers, and an accounting firm to build out their team. You dont want to wind up in a bind because you didnt have the right team of professionals by your side.

Our architects are classically trained, Tony mentions. And some have even taught previously. So they arent usually wrong when giving advice to our clients. That is something we pride ourselves on. We want whats best for our clients.

Bella Custom Homes is known for its classical and timeless architecture, but they can build any style of home that you desire.

Something we value is having a talented team of craftsmen working on our projects Stacy adds. Regardless of the price point of a build, our clients are going to get the same framers, same trim carpenters, same flooring installers because this is the team that weve culminated and we trust to get the job done.

Typically, you are starting with a blank canvas when building a home. The home buyer may have a list of wants for the home, but its really up to the builder to add in that wow factor.

Weve had a lot of clients tell us that their homes are better than being on vacation, Tony says. Most of our clients love the romantic architectural features we add, which is just one way we like to exceed expectations.

In order to be successful, home builders should look at the process as fun, enjoyable, and exciting because they are getting the privilege of making lifelong memories for their clients. Successful builders dont take that opportunity for granted.

Backyards are a feature we really like to take advantage of, says Stacy. We love to create an oasis where it makes it feel like youre at a resort. So many of our clients like to entertain so creating a destination that really wows them is another way we exceed expectations.

Tony mentions that Murphys Law is a huge part of this business. When something can go wrong, it typically goes wrong. However, in order to be successful, you have to be on top of things and cant pretend mistakes dont happen.

Everybody is human, they will make mistakes, Stacy mentions. But the important thing to remember is that oftentimes, everything can be fixed or changed. And we are a team that is determined to make things right.

This is probably the No. 1 secret ingredient to the success and longevity of your business. Clients are looking to you, as a professional, for your expertise. In order to have happy clients, its best to put yourself in the position to educate them along the way and guide them in their decision-making process.

We want happy clients. We want them to feel like they are truly getting the quality of work that they are paying for, says Tony.

Bringing new ideas to the table and creating the homes design inspiration is the fun part for me, Stacy says, During the design process, you get the opportunity to brainstorm with your clients. It becomes a fun challenge to find a tangible visual to showcase the clients wants and wishes.

Both Tony and Stacy are very passionate about what they do. And it shows in how they treat their clients. Tony believes in the importance of being approachable and available to his clients. Additionally, Tony is a Graduate Master Builder while Stacy is a Certified Graduate Builder so both have a wealth of knowledge they love to share with their clients.

We never work a day in our lives, Tony says. This is a business that once youre in it, youre in it for life.

Were available to our clients at all times. From selecting a lot to attending architect meetings, were there, Stacy adds. We enjoy the process and want to help guide our clients throughout. We also provide perspective to our clients. They might not be thinking about the big picture or future plans, so we like to be that soundboard for them.

BCH has repeat clients and has even built through families. Referrals are our best marketing and we take great pride in that. The team is grateful for all the clients that have trusted them to build their dream homes thus far, as well as the relationships forged, and look forward to building many more as Bella Custom Homes enters its 30th year of business in 2023.

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What is the Secret to Longevity in Real Estate? - CandysDirt.com - Candy's Dirt