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Category Archives: Transhuman News

Hawthorne man gets 34 years in woman’s 2004 murder after DNA from Orange County hit-run links him to case – OCRegister

Posted: May 20, 2017 at 6:24 am

LOS ANGELES A Hawthorne man linked through DNA evidence to the 2004 killing of a woman in South Los Angeles after his arrest for a fatal hit-and-run in Orange County pleaded no contest Friday, May 19, to murder and other charges.

Jaqwun Laerin Turner, 36, was immediately sentenced to 34 years to life in state prison following his plea to first-degree murder, kidnapping and assault with a deadly weapon, according to the Los Angeles County District Attorneys Office.

Turner was charged in 2015 with the April 10, 2004, slaying of Leah Deshay Benjamin, whose body was found wrapped in a blanket in an alley in the 10600 block of South Manhattan Place.

The 38-year-old woman died from blunt force head trauma, authorities said.

A background check of Turner revealed he had lived in close proximity to the area where Benjamins body was discovered, according to authorities.

Los Angeles police were notified in 2014 the California Department of Justice had gotten a match between Turners DNA profile and the DNA profile obtained from crime scene evidence. Los Angeles Police Department Robbery-Homicide Division detectives and members of the Scientific Investigation Division conducted a search of the location where Turner had once lived, and recovered DNA evidence linked to Benjamin although the property had been sold in 2005, according to police.

Turners DNA was collected after his arrest by Santa Ana police on Jan. 29, 2014, in the death of Martha Rodenza, 51, of Los Angeles. Rodenzas body was found on the northbound Santa Ana (5) Freeway at the westbound Garden Grove (22) Freeway after she fell from the truck just before 2:45 a.m. on Dec. 8, 2013.

Turner pleaded guilty in August 2014 to a felony hit-and-run charge and was sentenced to a year in county jail and five years probation.Orange County Deputy District Attorney Stephen Cornwell objected to theplea deal, saying later that Turner should have spent time in prison for leaving Rodenza to die alone in the road and failing to contact police.

Defense attorney Errol Cook, who represented Turner in the Orange County case, said last year that Turner had reluctantly agreed to give Rodenza a ride, and that his client was shocked, fearful and pretty much panicked after she opened the door and stepped out of the truck as he was trying to slow the vehicle.

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Hawthorne man gets 34 years in woman's 2004 murder after DNA from Orange County hit-run links him to case - OCRegister

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How to Sequence DNA in Space – The Atlantic

Posted: at 6:24 am

The International Space Station is one big research laboratory. Its earliest research objectives, back in 2000, were pretty straightforward: keep humans alive. Since then, the number of experiments conducted aboard the station has ballooned, and astronauts and cosmonauts spend their days studying how terrestrial science and technology works in microgravity. Over the years, the stations residents have grown zucchini, beheaded flatworms, maneuvered humanoid robots, tended to mouse embryos, watched the muscles of zebrafish atrophy, and drawn their own blood, using their own bodies as test subjects. Scrolling through NASAs full list of experiments, one gets the sense that almost any experiment that can be done in a lab on Earth can be replicated in one floating 200 miles above.

So it shouldnt be too surprising that humans have successfully sequenced DNA in space.

Last summer, NASA dispatched Kate Rubins, a microbiologist with a doctorate in cancer biology, to try it for the first time. Rubins has spent her career studying infectious diseases and worked with the U.S. Army to develop therapies for the Ebola and Lassa viruses. She has sequenced the DNA of different organisms plenty of times on the ground, but the process was a little bit more nerve-wracking on the space station. I didnt want to screw it up, she says.

I spoke to Rubins during her recent visit to NASA headquarters in Washington, D.C. about the experiments she worked on during her four-month stint on the ISS. Our conversation, edited for length and clarity, is below.

But first, a brief rundown of how DNA sequencing actually works. Rubins used a specially made biomolecule sequencing device, a miniature version of the microwave-sized hardware on Earth. DNA samples are fed into its protein nanopores, tiny structures embedded in a synthetic cell membrane. The device sends an ion current through this membrane. When the bases of DNAguanine, adenine, thymine, and cytosinemove through nanopores, they each create a change in the current. The device measures these tiny disruptions, and scientists use them to determine the sequence of the bases. For the human carrying this out, its actually pretty easy.

OK, lets go.

Koren: So when you first got to the space station, knowing what you know about how communicable disease works, did you ever have a moment when you realized, Im in a giant tube of germs?

Rubins: So were in a giant tube of germs all the time, right? Not to scare you. Sitting here, this room is filled with germs. Most germs arent bad. Youre in a microbial environment all the time. Whats interesting is that weve actually had this microbial environment thats been separate from Earth for 16 years. We havent had real problems with disease outbreaks or that kind of thing happening on the space station, but it is interesting to potentially study its microbial environment, what different species of bacteria there are, and how that changes over time. I would actually say its a little bit better, from an infectious disease perspective, to be isolated. So youre with three or six people, but you actually have less chance of being sick because its not like youre going through an airport or a subway ride where youre in contact with a bunch of people.

Koren: How did you start preparing for the DNA-sequencing experiment?

Rubins: Wed been working on it for a while. One of the questions we had was, how is the equipment going to survive launch? So we did launch vibration tests. We were also unsure about what would happen in microgravityyou get a lot of bubbles forming [in the solution]. Could we prevent bubbles from forming? We ended up deciding to sequence a mix of non-pathogenic viruses, bacteria, and mouse DNA because that gives you the range and complexity all the way from virus to mammalian organism.

Koren: Was there doubt it would work?

Rubins: Yeah, it was really an experiment. We were testing this technology and our question was, is this going be successful? And it was, luckily. But thats pretty much everything in science. You have a hypothesis, you go in, you test it, analyze the results, and see if you have to change anything about the experiment.

Koren: How did the experience compare to sequencing DNA on Earth?

Rubins: I was surprised at how well it worked. I had tried it out a few times on the ground just to see how the mechanics of loading everything would work, and then its pretty different in microgravity, right? You put the pipette on the sequencing flow cell, and you shoot back off in the opposite direction with the same amount of force that you put on the pipette. Anytime youre handling something, you have to stabilize yourself, so that took a little bit to get used to. I brought some foot restraints over and got myself hooked in. The first time I did it, I had a head lamp on so I could see really well, and some magnifying glasses.

Koren: How many runs did it take before it worked?

Rubins: It was actually successful on the first try, so that was great. We had some extra samples just in case it didnt work the first time, so we started actually changing the experiment a little bit. We altered a few parameters, like the length of time that the reaction runs. They all worked.

Koren: What was your reaction after that first successful run?

Rubins: I was extremely excited. I was really nervous loading it the first time. Im usually not nervous when Im just doing a normal bit of pipetting, but I didnt want to screw it up. There was a little bit of adrenaline going. Its within 10 minutes that you start to see the first sequence coming through.

Koren: Did it feel like 10 minutes? Because when youre anticipating something, time can feel like its moving slowly.

Rubins: Oh, no! I was like, I cant even be here. Ive got to float away and try to keep myself busy. And then Id come back and check again, and then Id float away again. We had a communications loop open with the ground team, so when we did start to see everything come through, they put the speaker on so I could hear them all clapping and cheering.

Koren: You also spent some time culturing human heart cells on the ISS. What was that like?

Rubins: Youre tending to the cellsyou have to change the media [in the cell culture], you have to resupply them with nutrients. Instead of having the open cell-culture plate, theyve got lure locks that are designed for space, and you can change the media with a little syringe. It took quite a long time to do the cell-culture change. I was nervous because I didnt want to contaminate the cell culture; if you get bacteria in there, itll overgrow your culture and kill the cells and ruin the experiment. You have to work on very sterile techniques. Its like prepping for surgery. You dont want any microbes getting in the patient.

Koren: Youve said you watched the heart cells beat in unison. How many cells does it take to see that?

Rubins: You can see 20 to 100 cells. For the most part, theyre in sheets or forming clumps or groups of cells, so you can see them together just synchronize that beating.

Koren: And is that weird to see?

Rubins: It was very cool. When I pulled the microscope out, the cosmonauts would come down from the Russian segment of the space station and everybody would float past because they liked watching it. Theres something fascinating about seeing down to the microscopic level and actually watching these heart cells beat.

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How to Sequence DNA in Space - The Atlantic

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State forensic panel approves use of familial DNA to ID suspects … – Newsday

Posted: at 6:24 am

A special state committee Friday approved a recommendation that New York State adopt the use of familial searching, an emerging DNA procedure employed in some states to identify potential suspects.

By a vote of 5-0, the DNA subcommittee of the New York State Commission on Forensic Science approved the plan to use familial searching, proposals that have been in the works since the beginning of the year. Under proposed guidelines, special DNA analysis will be allowed in cases of homicide, rape, arson and crimes involving a significant public safety threat.

The measure now goes to the full commission, which could vote on it next month. Familial searching is supported by the New York Citys five district attorneys, as well as NYPD Commissioner James ONeill.

Familial searching is a two-step process in which an unidentified DNA sample that doesnt match any genetic profile in the state database is given further analysis to see if it bears any similarities with known profiles. If similarities are found, the unknown samples Y-chromosome is further analyzed to come up with a likely relative of the unidentified person. Police will then locate the relative and possibly get a fresh DNA sample to compare it to what was found at the crime scene.

Though controversial, familial searching is now used in 10 states, including California and Colorado, as well as in the United Kingdom and the Netherlands. It has led to the solving of a number of cold case homicides. The method gained attention in New York after the August strangulation death of Howard Beach jogger Karina Vetrano. Investigators recovered an unidentified DNA sample from the 30-year-olds body but couldnt match it to any genetic sample in the state DNA database.

Vetranos family and law enforcement realized the usefulness of familial searching and lobbied for its use in New York State. However, conventional police work led to the February arrest of a man in the Vetrano case.

Critics, notably some civil libertarians and members of the defense bar, oppose familial searching on privacy grounds. They also believe that many of the DNA profiles already in the state database are from defendants of color and that familial searching would amount to genetic trolling that unfairly investigates black and Hispanic families.

But proponents of familial searching say the method is race neutral and would be involved in only a small number of cases. They also note that most of the victims of violent crimes, particularly in New York City, are black and Hispanic. Data from NYPD sources revealed earlier this year that in 2016 of the 11 unsolved homicides with DNA samples that couldnt be matched, nine of the victims were black and one Hispanic.

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State forensic panel approves use of familial DNA to ID suspects ... - Newsday

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Sisters’ murders unsolved years after killer’s DNA freed woman – Appleton Post Crescent

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Ann and Cecilia Cadigan were brutally murdered on their family farm in Casco, Wis., on Nov. 16, 1991. A decade after locking up the wrong person, the real killer of the Cadigan sisters continues to elude the Kewaunee County sheriffs department. Josh Clark/USA TODAY NETWORK-Wisconsin

Nov. 16, 1991. 90-year-old Ann Cadigan and her 85-year-old sister Cecilia Cadigan were murdered in their rural Kewaunee County home.(Photo: Beth LaBatte, Trial Exhibit)

CASCO -Cecilia and Ann Cadigan lived in a white, two-story farmhouse about 20 miles east of Green Bay. The two former school teachers had few visitors to their family's 1910-era farm before the day someone showed up with a pool stick.

A grain elevator calendar served as their daily diary. "Nov. 16, 1991, Noon, 43 Degrees," Cecilia Cadigan jotted down on her 85th birthday. The sisters had planned to eat an early Swiss steak dinner and were expected to attendthe 4:30 p.m. Mass at the nearby Holy Trinity Catholic Church.

Timeline: Cadigan sister murders

Related:Murder cases often go cold after exonerations

They never made it. About 6 p.m., neighbors found the sisters fatally stabbed and brutally beaten. Ann, who was 90 years old,was slumped over in her favorite chair. Cecilia's body was under a toppled couch. Blood stains were smeared into the living room's rose-colored carpet. The victims' purses were stolen.

Cecilia Cadigan, 85, was brutally beaten and fatally stabbed inside her farmhouse on Nov. 16, 1991. Her sister's slain body was found nearby.(Photo: USA TODAY NETWORK-Wisconsin)

They were in the living room,murdered, said neighbor Larry Tex Dellis. "Everybody was in shock.

Kewaunee County investigators caught what could have been a major break in the case: Someone, the likely killer, had left his genetic material all over the crime scene, including on one of the weapons used in the slayings. But they didn't know it at the time because DNA technology hadn't yet emerged as a powerful tool to identify perpetrators.

Instead, authoritiesfollowed up on suspects based on hunches and circumstantial evidence, discounting each one until they focused on Beth LaBatte of Green Bay as a prime suspect.LaBatte and her boyfriend Chuck Benoit of Sturgeon Bay, had committed a slew of burglaries, break-ins and thefts across northeastern Wisconsin, and they were charged in the sisters' deathsmore than five years after the bodies were discovered.

Ann Cadigan, 90, was found murdered in her family's farmhouse near Casco in 1991. The killing remains unsolved. In 1997, authorities convicted the wrong person, Beth LaBatte. Her case was eventually dismissed in 2006.(Photo: USA TODAY NETWORK-Wisconsin)

The village of Casco,population 600, was relieved that the nightmarish murders had been solved. That feeling of relief didnt last.

An Outagamie County jury found LaBatte guilty in 1997, but her trial judge, Dennis Luebke,overturned her convictions in November 2005. Charges were formally dismissed in August 2006. A year after she was exonerated, LaBatte died in a rollover crash near Redgranite.

As for Benoit, an Ozaukee County jury found him not guilty at his 1998 trial. Even so, he said he has forever been tainted by the wrongful prosecution. "This crap is still over my head," said Benoit, who is now in his 60s, lives in Green Bay, and says he has turned his life around since his younger days.

When the cases against LaBatte and Benoit unraveled due to DNA evidence that pointed to their innocence, the Cadigan murder investigation went inactive. Their killer or killers have escaped justice for 26-plus years.

The Cadigan case highlights a common dilemma in DNA exonerations across the country: The same law enforcement agency involved in the initial miscarriage of justice often remains in control of the case.

Nov. 16, 1991. 90-year-old Ann Cadigan and her 85-year-old sister Cecilia Cadigan were murdered in their rural Kewaunee County home.(Photo: Beth LaBatte Murder Trial Exhibit)

For many agencies, a flawed murder investigation is something they would rather not reopen and pursue aggressively.

"There are cases that law enforcement do take the initiative to follow up on the new leads, but in many, many, cases they still don't want to admit that they made a mistake," said Jim Trainum, a retired Washington, D.C. Metropolitan Police homicide detective who has published a book pertaining to wrongful convictions.

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"Too often, we want to sit on our hands, and we depend on technologyinstead of asking ourselves, 'What went wrong and is there anything else we can do on this case?'"Trainum said.

In 1997, Beth LaBatte of Green Bay was wrongfully convicted of the 1991 murders of Ann Cadigan, 90, and her sister Cecilia, 85, of rural Kewaunee County. The killer remains at large.(Photo: USA TODAY NETWORK-Wisconsin)

LaBatte's wrongful conviction "brings up a lot of old hurt," said her mother, Maria Brunette. The Algoma woman sat through the trial where her daughter was convicted of a double murder and given a life sentence while the real killer eluded justice.

"I would love to see the person go to prison," she said. "They should be prosecuted."

This month marks 12 years since Kewaunee County learned that none of the DNA evidence recovered from the Cadigancrime scene matched LaBatte. According to 2005 court documents, DNAextracted from one of the recovered murder weapons and one of the victims came from an unknown male attacker.

Asked why his agency hasnt publicized the case for new leads, Kewaunee County Sheriff Matt Joski said, "I don't know if it's productive and beneficial" because the Cadigan murders arealready well-known around the area.

Kewaunee County Sheriff Matt Joski said his agency still hopes that the 1991 double murders of the Cadigan sisters can be solved through the federal law enforcement's criminal offender DNA database.(Photo: Joshua Clark/USA TODAY NETWORK-Wisconsin)

"As a community, it's always something that weighs on our mind," Joski said. "I think if something substantive came forward, I'd expect we would move forward. I've never had anyone that we could have taken to the court for charging."

Joski hopes the FBI's criminal justice DNA databasewill eventually unmask the killer. Every year, more criminals get added to the offender database, increasing the odds for a DNA match, he said.

"Samples have been submitted to allow things to (go)further in the investigation," Joski said. "It's just that a long time has elapsed ... We can't just develop or create a suspect."

The killer had left DNA on one of his murder weapons a bloody pool stick, which snapped during the slayings. Its sales tag was traced to a Kmart in Sturgeon Bay. The killer also left DNA on a pair of white socks he used to wipe up Cecilia Cadigan's blood. Additional DNA was extracted from two hairs found on Cecilia Cadigan's body, court documents show.

Keith Findley, co-director at the Wisconsin Innocence Project, said law enforcement's reliance on the federal criminal database to uncover a DNA match is one of the reasons the Cadigan murders have become a cold case. His innocence team took up LaBattes case and won herexoneration.

"I'm a little surprised and I'm disappointed," Findley said."We had asked for them to reopen the investigation. ... We never really got any additional information from them."

Madison lawyer Keith Findley of the Wisconsin Innocence Project was instrumental in proving that Beth LaBatte was wrongly convicted of the Nov. 16, 1991 brutal beatings and stabbings of Cecilia Cadigan, 85, and her sister Ann, 90.(Photo: University of Wisconsin Law School)

Findley's team unraveled the flawed case of former Kewaunee Countyprosecutors Jackson Main and Elma Anderson. Main and Andersonconvicted LaBatte with no physical evidence and no eyewitnesses linking her and Benoit to the crime scene.

Instead, the two prosecutors relied on now-discredited testimony from a handful of prisoners who testified that fellow inmateLaBatte confessed to murdering and robbing the elderly sisters.

Main, who has since died, speculated in the courtroom that LaBatte experienced a drug-induced blackout, causing her alter ego known as "Bad Beth" to go on a wild rampage inside the farmhouse.

"Bad Beth would know what happened," Main told the jury.

Even though DNA tests later proved LaBatte was innocent, some local residents still wish she had never been released from prison.

"DNA got her off," scoffed Tex Dellis, whose brother and sister-in-law discovered the bodies of the Cadigan sisters. "I do feel she was involved, but this case has never been totally solved."

That kind of sentiment fueled in part by the Sheriff's Department's strategy in trying to solve the cold case has left LaBatte's family infuriated. Her mother contends the decision to let the double murders go by the wayside is appalling.

"No matter how hard you try to clear her name, it just won't work in this county," Brunette said. "I used to call the sheriff's office up, and I checked to see if it was getting solved. I was always being told, 'It's under investigation.It's under investigation.' Well, if you're not collecting any DNA from anybody, then I'm sure you're not going to get any hits."

Nov. 16, 1991. 90-year-old Ann Cadigan and her 85-year-old sister Cecilia Cadigan were murdered in their rural Kewaunee County home.(Photo: Murder Trial Exhibit Beth LaBatte)

Long before LaBatte and Benoit were arrested, authoritiesspent three unproductive years targeting a young man from Colorado as their prime suspect. The man, then 22, had lived in rural Casco and several people told investigators that he had an explosive temper, was supposedly broke and regularly shot pool, court documents reflect.

The man drew heightened suspicion because he moved back to Colorado just four days after the slayings. During the 1990s, he denied involvement and a warrant to search his station wagon in Colorado yielded no forensic evidence. By 1995, investigators disregarded him as a suspect.

In the months after the killings, investigators for Kewaunee County and the Wisconsin Department of Justice also explored whether an inheritance dispute provoked the murders. The Cadigan sisters had never married and had no children and it was revealed their estate was worth at least $500,000.

But that angle never panned out.

A male relative of the Cadigans from Milwaukee drew suspicion after investigators learned that he cryptically asked a girlfriendwhether she believed he could be the killer, Wisconsin Department of Justice records show. The man often visited Green Bay and the Fox Valley on weekends. According to DOJ reports, hetold investigators "he had not been to the Cadigan residence since ... 1989 which appears to be contradicted by information received from ... a friend of the Cadigans."

In 1992, investigators told the man his alibi was shaky. He "replied that he has thought about Nov. 16, 1991 (the date of the murders) and can't produce any new information." The two investigators spent days trying to persuade the man to take a polygraph test. He declined. It's unclear why investigators backed off the man as a suspect.

By 1995, investigators latched on to the theory that LaBatte committed the slayings while Benoit waited outside the farmhouse in his car and served as her lookout.

But at Benoit's trial, his lawyer David Christian of Green Bay presented evidence that his client and LaBatte didn't even meet until February 1992 three months after the slayings.Although Benoit was acquitted, he went to prison for about seven years for his role in burglarizing a Manitowoc County supper club.

During LaBatte's post-conviction appeal, Benoit furnished a DNA sample to prove he was not the killer, he recently told USA TODAY NETWORK-Wisconsin.

"I was told it wasn't a match," he said.

The case left Benoit feeling bitter for years. Unlike LaBatte, he is not classified as an exonoree because he was found not guilty.After prison, Benoit said he worked in Appleton as a metal fabricator until 2011 when he suffered a heart attack and underwent triple bypass surgery.

"I avoid Kewaunee County at all costs, Benoit said. I've had an opportunity to rent places there, but won't do it. I don't have any respect for them at all. Whether they knew what they were doing is up in the air."

Benoit, too, is upset that local sheriff's deputies haven'tarrested the person or persons who killed the Cadigan sisters.

I dont think they have a clue, Benoit said. Its just unreal to just let it go."

He and LaBatte never reconnected after her murder charges were dismissed in 2006.

"I wanted to see the past stay in the past," Benoit said.

After her exoneration, LaBatte moved to Fond du Lac County where she lived with a boyfriend. On Sept. 1, 2007, she went to a Wautoma tavern and later tried to drive home. She lost control of the truck on Wisconsin 21 near Redgranite and hit a ditch. LaBatte was thrown from the truck and died of massive injuries. Authorities in Waushara County determined her blood alcohol level was 0.21 percent, more than double the legal limit for drivers.

Nov. 16, 1991. 90-year-old Ann Cadigan and her 85-year-old sister Cecilia Cadigan were murdered in their rural Kewaunee County home.(Photo: Murder Trial Exhibit Beth LaBatte)

The weathered farmhouse where the Cadigan sisters lived and the red barns on the property still stand. The sisters share a tombstone in Casco at the peaceful cemetery across from their church.

Dellis, the neighbor, now owns the 130-acre farm. The house has served as a rental property over the years. He's thought about demolishing the dwelling, but that would cost him thousands of dollars.

Today, 26 years later, the haunting double murders stirnothing but awful memories.

Dellis is confident the case will never be solved.

I feel it was bungled from the start; Ill just leave it at that, he said. "Thats the trouble with this case. The public would like it solved, but time has passed too much and the principal people are gone.

Findley, of Wisconsin's Innocence Project, questions why solving the Cadigan murders hasnt been a top investigative priority.Why is Kewaunee County content to let the case go inactive?

Sometimes, theres a reluctance to ask about why errors were made, Findley said. Im not judging what was done or what they could be doing because I dont know.

Certainly, there should not be any reluctance because someone was wrongfully convicted in the first place. Its a horrible crime and the reality is its unsolved, and thats problematic.

September marks the 10-year anniversary since LaBatte's tragic and troubled life came to an abrupt end.

The words she spoke at her 1998 sentencing still ring true:

"God knows that I'm innocent. I'm not guilty, and I know that the Cadigan sisters and Kewaunee County will not be able to rest until the real killer is found."

In 1997, Beth LaBatte was wrongfully convicted of murdering two elderly sisters who lived in Kewaunee County. Her convictions were later overturned after DNA evidence proved that the real killer was an unknown male.(Photo: USA TODAY NETWORK-Wisconsin)

John Ferak of USA TODAY NETWORK-Wisconsin: 920-993-7115 orjferak@gannett.com; on Twitter@johnferak

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Sisters' murders unsolved years after killer's DNA freed woman - Appleton Post Crescent

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Uyghurs Forced to Undergo Medical Exams, DNA Sampling – Radio Free Asia

Posted: at 6:24 am

Ethnic Muslim Uyghurs in northwest Chinas Xinjiang region are being given mandatory health examinations that include DNA collection, according to residents, causing concern among some observers who have called on Beijing to explain its motive behind the mass checkups.

According to reports by Chinas state media, the General Peoples Health Examination Project that began in September 2016 and ended in March this year provided checkups for 17.5 million people throughout the region, including 9.2 million in predominantly Uyghur-populated southern Xinjiang.

The examinations were carried out on more than 90 percent of the residents of the entire region, and more than 98 percent of the population of southern Xinjiang, the reports said, adding that the project had been 100 percent implemented in Hotan (in Chinese, Hetian)a prefecture almost exclusively inhabited by Uyghurs.

Authorities in Xinjiang appropriated 180,830,000 yuan (U.S. $26.2 million) for the General Peoples Health Examination Project, initially deploying mobile health checkpoints to Hotans Guma (Pishan) county, Aksu (Akesu) prefectures Uchturpan (Wushi) county, and Ghulja (Yining), Nilqa (Nileke), and Qorghas (Huocheng) counties in Ili (Yili) Kazakh Autonomous prefecture, before rolling out the program to the rest of the region.

Official reports said patients were divided into categories by ageinfants to six-year-olds, seven to 14-year-olds, 15 to 65-year-olds, and 65-year-olds and aboveand given a battery of tests that included examinations of the heart, blood, DNA, urine, and blood sugar using electrocardiograms, x-rays, and ultrasounds.

Uyghur residents recently told RFAs Uyghur Service that they were pressured and, in some cases, forced to undergo examinations, and that the results of their tests were stored on a computer system during the checkup.

A Uyghur official from southern Xinjiang, who spoke to RFA on condition of anonymity, said all of the staff in her department were required to participate in the examination, while her husbands examination was arranged by his work unit and her childrens checkups through their schools.

When they filled out the forms for the checkup, our ethnicity had to be listed clearly, as well as our religious affiliation, she said, adding that her work unit had completed the paperwork for her.

However, they never showed us the results [of the tests]. I dont know if people have been demanding the results or not.

A female college student in Hotan, who also asked not to be named, said she was required to undergo an examination in December last year, along with all of the other students in her school.

They conducted the examination, but didnt give us the resultsthey just said you are healthy and that was it, she said.

They took blood, checked our lungs and hearts. They took blood from our arms and said if there was anything wrong they would inform us, but they never did.

The student said that four other members of her family eventually underwent examinations, including her father, mother, and two brothers.

A farmer from Payziwat (Gashi) county in Kashgar (Kashi) prefecture told RFA that county officials and medical personnel had set up a health checkpoint in front of the area hospital, and local cadres urged residents to get examined.

The farmer said that he and his wife and three children were happy to receive free checkups, but added that he was puzzled over what he called a special focus on women during the examination, without providing further details.

A nurse from the Central Hospital of Uchturpans Zawa township told RFA that a lack of medical personnel had kept her examining the areas large number of residents non-stop through March to meet the projects deadline.

When asked for the reason behind requiring all of the residents of the region to undergo health examinations, a Han Chinese official at the Party Committee of Guma county told RFA nobody at his level knew.

Ask the county government, he said. All we did was implement the order that came from the top to examine everyone.

Project questioned

Observers from the overseas Uyghur exile community told RFA that while free health examinations could benefit inhabitants of the region who might not otherwise have access to health care, the vast expenditure and mobilization of resources, as well as the forced nature of the checkups, raised serious questions about the program.

The Uyghur people must pay special attention to these examinations, said Enver Tohti, a U.K.-based Uyghur physician.

Such a large-scale collection of Uyghur biological information by the Chinese government threatens the very security of the Uyghur people and the survival of the Uyghur race.

Tohti called on the United Nations World Health Organization to request an explanation from the Chinese government regarding the reason behind its examination project.

Earlier this week, rights groups and academics said Chinese authorities in Xinjiang are carrying out mass collection of DNA from individuals not suspected of any crime, with New York-based Human Rights Watch (HRW) noting that police had already gathered samples from 44 million individuals on a nationwide database, collected without oversight, transparency, or privacy protections.

"Authorities have stated that the DNA databases are used for solving crimes, including terrorism and child trafficking, as well as to identify bodies and vagrants," the group said.

Chinese police in Xinjiang have required all passport applicants to submit DNA samples since November 2016, while police agencies have issued multimillion dollar tenders for the supply of gene sequencing equipment, HRW said.

Leaked tenders by regional governments have said biometric information is being gathered as part of China's nationwide "stability maintenance" regime targeting peaceful critics of the ruling Chinese Communist Party.

Dilxat Raxit, spokesman for the exile group World Uyghur Congress, called the policy part of an overall policy of ethnic profiling of Uyghurs by the Chinese government.

China regularly conducts strike hard campaigns in Xinjiang, including police raids on Uyghur households, restrictions on Islamic practices, and curbs on the culture and language of the Uyghur people, including videos and other material.

While China blames some Uyghurs for "terrorist" attacks, experts outside China say Beijing has exaggerated the threat from the Uyghurs and that repressive domestic policies are responsible for an upsurge in violence there that has left hundreds dead since 2009.

Reported by Eset Sulayman, Gulchehra Hoja, and Jilil Kashgary for RFAs Uyghur Service. Translated by Alim Seytoff and Mamatjan Juma. Written in English by Joshua Lipes.

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Uyghurs Forced to Undergo Medical Exams, DNA Sampling - Radio Free Asia

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Exhumed priest’s DNA doesn’t match evidence in case of ‘Sister Cathy’ slaying from 1969 – Washington Post

Posted: at 6:24 am

The unsolved slaying of Sister Catherine Ann Cesnik in Baltimore in 1969hit another dead end Wednesday when police learned that DNA from a long-deceased priest did not match crime scene evidence that Baltimore County policehave preserved for almost five decades.

In February, police exhumed the body of the Rev. A. Joseph Maskell, the former chaplain at Archbishop Keough High School in Baltimore, where Cesnik had taught. Years after Cesnik disappeared in November 1969, and her remains were discovered in the Lansdowne area of Baltimore County in January 1970, a number of women came forward and accused Maskell of sexually abusing them while they were students at Keough. Two of the women sued Maskell, the high school and the Archdiocese of Baltimore in 1994, but the suit was dismissed because ofan expired statute of limitations. Maskellbecame a suspect in Cesniks death but denied any involvement to police. He died in 2001.

[Decades after a nun was slain, police exhume a priests body. This cold case is Netflixs latest mystery.]

The death of the popular Sister Cathy is the subject of an upcoming documentary series, The Keepers, to be released Friday on Netflix.

Baltimore County police said Maskells DNA was sent to Bode Cellmark Forensics in Lorton, Va., to develop a DNA profile. The profile was compared tocrime scene evidence and did not match, police said.

Maskell was not the first person whose DNA has been compared to the Cesnik crime scene over the years, Baltimore County police spokeswoman Elise Armacost said. She said detectives had obtained about a half-dozen DNA profiles and compared them to the crime scene. But so far, no matches. The DNA profile from the crime scene has also been placed into the FBIs national DNA system, also with no hits so far.

Cesnik, 26, was last seen at a shopping center in Baltimore City on Nov. 7, 1969. Another young woman, Joyce Malecki, 20, disappeared from a shopping center in Glen Burnie four days later and was found slain two days after that. And two 16-year-old girlssubsequently were abducted and killed from Baltimore area shopping centers in 1970 and 1971. All are unsolved. Armacost said police are still investigating whether the four killings might be related.

Women who say they were abused by Maskell have said that they told Cesnik of the situation, and she may have been preparing to confront Maskell. Cesnik had moved out of her Baltimore convent and left Keough earlier in 1969, teachingat Western High School and living in an apartment with another nun. One of the women who say they were abused by Maskell told the Baltimore Sun in 1994 that the priest took her to see Cesniks body in Lansdowne, to warn her aboutrevealing her own situation. The Archdiocese of Baltimore subsequently paid settlements to 13 women who alleged that Maskell molested them, lawyers for the women said.

Sister Cathy was a nun, Armacost said earlier this month. So the theory that she was killed because of something she knew in the Catholic Church was something weve been looking at. However, weve never proven thats why she was killed. So there are other theories we are looking at as well.

Following the disclosure that Maskells DNA was not a match, Armacost said Wednesday that Baltimore Countys cold case detectives would continue working the case. Their best hope for solving the case now, Armacost said, lies with the people who are still alive and willing to come forward with conclusive information about the murder. They are cautiously optimistic that the renewed, intense interest in the case may generate useful new leads and encourage people with solid evidence about Sister Cathys murder to come forward to police.Its possible that in the future new forensic technologies will provide new options for testing the remaining crime scene evidence, but for now we have reached the end of the road with forensic evidence in this case.

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Silicon Valley DNA vs. NDAs – TheStreet.com

Posted: at 6:24 am

When Uber bought self-driving truck developer Otto for $680 million less than a year ago, the ride-sharing company proclaimed in a blog post that it had created a "dream team."

Uber hailed the arrival of Otto founder Anthony Levandowski. "Anthony is one of the world's leading autonomous engineers: his first invention, a self-driving motorcycle called Ghostrider, is now in the Smithsonian," Uber gushed. Levandowski had developed autonomous car technology for Alphabet's (GOOGL) self-driving car unit, now known as Waymo. "Just as important, Anthony is a prolific entrepreneur with a real sense of urgency."

The sense of urgency has only increased, though not in the way Uber expected.

Levandowski is at the center of trade secrets litigation that Waymo brought against Uber, accusing the engineer of stealing 14,000 documents on his way out the door when he left to found Otto in January 2016.

Former trophy hire Levandowski has until the end of the month to provide Alphabet's Waymo with documents that he allegedly downloaded or face termination from Uber, as per a May 15 letter from General Counsel. Judge William Alsup, who is hearing Waymo's suit in the U.S. District Court for the Northern District of California in San Francisco, mandated the return of the files.

While the dispute between Waymo and Uber is dramatic and riveting, it is not unique. Augmented reality company Oculus, which Facebook (FB) acquired for $2 billion in 2014, drew similar accusations from Zenimax. Tesla (TSLA) recently sued a former program manager of its Autopilot advanced driver assistancesystemunitfor breach of contract. Complicating matters in Silicon Valley, California does not recognize non-compete clauses that could block employees in other regions from hopping to a rival with prized intellectual property.

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DNA tests tell LeMoyne Center youth who they are – LancasterOnline

Posted: at 6:24 am

WASHINGTON, Pa. (AP) Alexandra Berumen thought she was European and Mexican. Wrong.

Serena Pierce thought she was Italian and German. Wrong.

Deitrick Stogner thought he was African-American. Partly wrong.

They and two other after-school program participants at LeMoyne Community Center - Kaprice Johnson and Daisean Lacks - submitted to DNA testing to determine their true ethnic makeup. They tested through ancestry.com and africanancestry.com in January, and four youngsters were surprised by the DNA results. One remains puzzled.

"No one is one thing. We're all a hodgepodge of many things," Joyce Ellis, executive director of the center, told a group of about 30 youngsters Thursday. They gathered in a room inside the East Washington center to watch a video related to the quintet's quest to find out - as Ellis put it - "Who do you think you are?"

Videographer Allen Bankz posed that question in January, after the five test subjects submitted saliva samples as DNA evidence. One by one, from behind his camera, he asked them what they believed their genealogies to be and recorded their responses. The interesting part would come later, when the results arrived and the kids would read them - for the first time - for a second filming.

The comparison of perception and reality promised to be interesting.

The results, though, came back later than Ellis expected. She was hoping to have them in time for the center's annual Black History Month celebration at the end of February, but the only ones to arrive by then were for Kaprice and for Ellis, who likewise wanted to be tested. The other results came in only recently.

Thursday afternoon, Alexandra and Serena were the only kids who did not know their true ancestries. Bankz was poised to film them a second time. The girls certainly weren't prepared for the results.

Alexandra, whose father owns Las Palmas, a Hispanic grocery in Washington, found out she is 57 percent American Indian and 36 percent European.

"Surprised?" Ellis asked, smiling.

"Mostly," said Alexandra, who looked mostly astonished.

Serena knew one great-grandmother was from Italy and that she had relatives from Germany and Ireland, but was semi-stunned to see she was 52 percent Irish, 15 percent Scandinavian and only 8 percent Italian.

Deitrick considers himself to be an African-American teen with a heavy concentration of relatives in the Chicago area. He also has a grandmother who is partly American Indian. But he is more European (52 percent) than African (43 percent), with a mix of many nations.

"I had no idea I was that much of a mix," he said.

Daisean has an interesting ancestral link. He is a descendant of Henrietta Lacks, who has gained renown as an unwitting contributor to amazing medical advances. Before she died of cervical cancer in 1951, at age 31, doctors removed two cervical samples without telling her. Henrietta's HeLa cells have been multiplied and used in a number of biomedical research procedures, and were instrumental in Jonas Salk's development of the polio vaccine.

In January, Daisean said his father is African-American, his mother is white and his family is mostly from Pittsburgh. He eventually discovered he is 33 percent Ivory Coast of Ghana, 21 percent Nigerian and 13 percent European. He was the only test subject who was not on hand for the DNA program Thursday.

Kaprice received her report more than two months ago and still considers it to be vague. She was told she has a gene that traces back about 15,000 years, and has a European background - without a breakdown of that background. Kaprice said a number of family members have hailed from around Carnegie and Pittsburgh, and that her mother is Irish with red hair.

Ellis also was surprised at her results, She said she is 36 percent European, with elements of France, Germany, England, Italy and Ireland - nations she, coincidentally, has visited. Ellis said she also is 24 percent West African descent.

"I'm zero percent native American Indian, which I thought might be the highest (percentage)," Ellis added.

Yet she wasn't totally surprised. When it comes to ancestry, the LeMoyne Center director realizes anything is possible.

"Skin tone is no matter," she told her young audience Thursday. "It's what the DNA says."

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The Genius Who Helped Unlock the Human Genome Is Taking On the Opioid Crisis – Mother Jones

Posted: at 6:23 am

Francis Collins, the gregarious 67-year-old who directs the National Institutes of Health, doesn't shy away from a challenge. Collins made a name for himself in the early 2000s when, as director of the Human Genome Project, he oversaw the completion of sequencing 3 billion genes. Now, as the head of the nation's foremost biomedical research engine, Collins faces a new task: finding solutions to the opioid epidemic, which killed more than 33,000 Americans in 2015.

"I'd like all of us, the academics, the government, and the private sector, to think about this the way we thought about HIV/AIDs in the early 1990s, where people were dying all around us in tens of thousands."

At the Prescription Drug Abuse and Heroin Conference last month, Collins announced a public-private partnership, in which the NIH will collaborate with biomedical and pharmaceutical companies to develop solutions to the crisis. President Donald Trump and Health and Human Services Secretary Tom Price "strongly supported" the idea, he said. This isn't Collins' first such partnership: During his tenure as directorBarack Obama appointed him in 2009Collins has developed ongoing collaborations with pharmaceutical companies such as Lilly, Merck, and GlaxoSmithKline for Alzheimer's disease, diabetes, and rheumatoid arthritis. For each partnership, the NIH and the companies pool tens of millions of dollars, with the agreement that the resulting data will be public and the companies will not immediately patent treatments. The jury's still out on resultsthe partnerships are about halfway through their five-year timelines. But Collins, a self-described optimist, remains hopeful. "Traditionally it takes many years to go from an idea about a drug target to an approved drug," said Collins at the conference. "Yet I believea vigorous public private partnership could cut that time maybe even in half."

I talked to Collins about the partnership, potential treatments in the pipeline, and the NIH's role in confronting the ongoing epidemic.

Mother Jones: Why is a public-private partnership needed?

Francis Collins: While NIH can do a lot of the good science, and we can accelerate [it] if we have resources, we aren't going to be the ones making pills. Many of the large-scale clinical trials are not done generally by us but by the drug companies. A successful outcome herein terms of ultimately getting rid of opioids and the deaths that they causewould not happen without full engagement by the private sector.

MJ: Which companies will be involved?

FC: It will be a significant proportion of the largest companies. I can't tell you the total listas I said, the 15 largest were there. Certainly the groups that already have some drugs that are somewhere in the pipeline will be particularly interested in ways to speed that up.

MJ: What do you hope will come out of it in the short term?

FC: I think that we could increase the number of effective options to help people get over addiction, and [the] treatments for overdose, particularly when fentanyl is becoming such a prominent part of this dangerous situation. The current overdose treatments are not necessarily as strong as they need to be. We could make progress there pretty quickly, I thinkin a matter of even a year or twoby coming up with formulations of drugs that we know work but in a fashion that would have new kinds of capabilities. [The drugs would be] stronger, as in the overdose situation, or have the potential of longer-acting effects, as in treating addiction. [It's] not necessarily a different drug, but a different formulation of the drug. And drug companies are pretty good at that.

MJ: And in the long term?

Without pharmaceutical companies, "we'd be completely hopeless as far as new treatment."

FC: The goal really needs to be to find nonaddictive but highly potent pain medicines that can replace the use of opioids given the terrible consequences that surround their use. This will be particularly important for people who have chronic pain, where we really don't have effective treatments now. The good news is that there's a lot of really interesting science pointing us to new alternatives, [like] the idea of coming up with something that interacts with that opioid receptor but only activates the pathway that results in pain reliefnot the somewhat different pathway that results in addiction. That's a pretty new discovery that could actually be workable, and a lot of effort ought to be put into that.

I'd like all of us, the academics, the government, and the private sector, to think about this the way we thought about HIV/AIDs in the early 1990s, where people were dying all around us in tens of thousands. Well, that's what's happening now with opioids. This ought to be all hands on deckwhat could we do to accelerate what otherwise might take a lot longer? It's interesting talking to the drug companies, who have really gotten quite motivated and seem to be determined to make a real contribution here. There are quite a number of new drugs that are in the pipeline somewhere, and they haven't been moving very quickly, because companies haven't been convinced there was enough of a marketopioids are relatively cheap. And also they've been worried that it would be hard to get new pain medicines approved if they had any side effects at all. Now that we've seen opioids have the most terrible side effect of allnamely, deathit would seem that as new analgesics come along, that the ability to approve some that might give you a stomachache now and then would probably be better.

MJ: There's a lot of wariness of big pharmaceutical companies right now, given Big Pharma's role in creating this problem to begin with. How do you make sure that whatever treatments are developed are affordable?

FC: That's a very big concern for everybody right now. It's front and center in these discussions about development of new drugs and pricing of existing drugs. And I don't know the full answer to that. This is just part of a larger discussion about drug pricing which applies across the board, whether we're talking about drugs for cardiovascular disease or cancer or, in this case, alternatives for opioids. But we need them. As much as people might want to say, "Oh, pharmaceutical companies, they're all just out to make money," they also have the scientific capabilities and they spend about twice what the government does on research and development. If they weren't there, we'd be completely hopeless as far as new treatment.

MJ: Trump's latest budget proposes a 20 percent cut to the NIH for 2018. Are you worried about having enough funding?

FC: Of course I am. And not just for this, but for all the other things that NIH is called upon to do as part of our mission. I'm an optimist, and what I have seen in my 24 years at NIH is that opportunity in medical research is not a partisan issueit's not something that's caught up in politics most of the time. And having seen the enthusiasm represented by the Congress in their passage of the 21st Century Cures [Act] just four months ago with incredible positive bipartisan margins, I think when the dust all settles, people will look at these kinds of investments and see them as a high priority for our nation. But of course, that's my optimistic view.

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First In Vivo Human Genome Editing to Be Tested in New Clinical Trial – The Scientist

Posted: at 6:23 am


The Scientist
First In Vivo Human Genome Editing to Be Tested in New Clinical Trial
The Scientist
Sangamo Therapeutics will use zinc finger nucleases to introduce the gene for a missing clotting factor into the livers of men with hemophilia B.

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