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Category Archives: Transhuman News

Sexual attraction is all in your genes, baby – Metro US

Posted: June 6, 2017 at 5:47 am

Instead of asking, Whats your sign? you should be asking a potential mate, Whats your genetic HLA blueprint?

It wasnt the dog in his profile picture or the kissy face emoji she sent you that attracted you to "the one" it was science.

via GIPHY

Humans have their own unique human leukocyte antigen (HLA) complex. HLA helps the immune system figure out which are its own cells and which are viruses and bacteria.

A study published in Nature studied attraction patterns in 254 couples and found that a partner with a different HLA pattern "correlates with sexuality and enhances the desire to procreate."

Opposites attract.

The study concluded that couples with differing HLA complexes found the scent of their partner even more appealing, but whether its genetics or just being enamored with the person, isnt clear.

via GIPHY

Men and women of various cultures seek out perfumes which highlight their body odour in the most desirable way, the study authors wrote. The famous novel Perfume by Patrick Suskind describes a perfume made of body odours that drives people into ecstasy and makes them forget civilized behaviour. However, recent research indicates that the olfactory match between people, rather than a universally irresistible smell, might be the key to olfactory attraction.

You and me baby ain't nothin' but mammals, so let's do it like they do on the Discovery Channel.

This olfactory attraction has evolutionary benefits, too.

Researchers found that if two animals with different major histocompatibility complexes (MHC) the equivalent of humans HLA mated, their baby would have an extremely strong immune system.

Study authors concluded: Attraction is a miracle to most of us and only some of the many factors mediating mate choice involve odours. However, within the world of human olfaction, there seems to be no perfect mate but a perfect partner and this depends on HLA match.

And if the Bloodhound Gangs 1999 hit is stuck in your head, youre welcome.

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Can Superhuman Mutants Be Living Among Us? – Gizmodo

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After millions of years of evolution, our species has, like an aging rock band, settled into a comfortable, familiar groove: Your classic bipedal, theory-of-mind-having Homo sapiens. Then, there is another class of human. This class of human has spectacular powers, such as mind control or the ability to manipulate electromagnetic waves, and exists mostly in big-budget global superhero franchises, like X-Men (or in mid-budget Ben Stiller-starring cult classics from 1999, like Mystery Men).

These characters arent generally celebrated for their realismbut are they really so implausible? Is it so hard to believe that, in some late-career burst of creativity, human beings might finally get it together and start evolving some wings, or night vision, or whatever?

For the latest installment of Giz Asks,we asked evolutionary biologists, academics, and futurists if it is at all possible that people with superhuman abilities are living amongst us, or one day will, and which of these abilities are the most scientifically plausible. They let us know that while mutant-humans probably arent evolving alongside us, there are certain scenarios (a move to Mars, say, or wide-scale climate-related devastation) which might bring about humans with radically different genetics in the distant future. Or, via genetic modification, in the next few months.

Scott Solomon is a biologist, professor, and writer; author of Future Humans: Inside the Science of Our Continuing Evolution; he currently teaches ecology, evolutionary biology, and scientific communication as a Professor in the Practice at Rice University in Houston, Texas.

Its unlikely that natural selection is currently operating to give people telepathy or mind control. And its fair to say that traits which defy the laws of gravity, like flight, are unlikely to ever evolve in humans. But one thing thats being developed now is technology that allows us to make changes to our DNA, through the use of CRISPR/Cas 9 which is a way of editing genomesincluding, in principle, the human genome. That is setting up a scenario in which, in the near future, it might be possible to make changes to humans and other organisms in very specific, deliberate ways... if were talking about traits that are at least physically possible.

For example, humans are able to see within a certain range of lightwe so call it the visible light spectrum, because thats what we can see. But insects in some cases can see light that is invisible to humansultraviolet light, as an example. So that means that its physically possible for an organism to see UV light, we just dont have the ability to do that, because our photoreceptor cells in our eyes arent attuned to those wavelengths of light. So if we knew all of the genetics that allow an insect to see light in the ultraviolet spectrum then at least in theory it might be possible to alter our own genes to allow humans to see light in the UV range as well.

And likewise some organisms can detect heat in the infrared spectrumfor example some species of snakes, or some insects. So again if we understood the genetics of that, then at least in theory we could manipulate our own genes in order to allow us to do that. Whether or not we should do that is a whole other question. But history seems to suggest that when humans develop the ability to use a particular type of technology, we tend to use it.

For a new species of human to evolve [naturally], there needs to be some sort of reproductive barrier. There would need to be something keeping this other type of human from mating with us. The current trend, on earth, for humans, is for populations to be coming together and mixing their genes... But if you send some people to Mars, and they start adapting to conditions therewhether through natural selection, or deliberately editing genes to try to make it easier for them to live on other planetsthat might lead us down a path where you have a new species evolving.

Living and boning in spaceparticularly on Marshas fascinated our degenerate species for decades.

Professor, Department of Biology, University of Washington; author of multiple books, most recently A New History of Life: The radical new discoveries about the origins and evolution of life on Earth, with Joe Kirschvink

Its all about super-soldiers. This is what the holy grail is going to be: getting that better military creature. Nothing is more efficient than biological structureno silicon, no metal. A soldier whos much harder to bleed to death, or a soldier that doesnt need to drink as much water, or doesnt need to eat for five or six days, or doesnt need to sleepany one of these things would be an enormous advantage in warfare. [With CRISPR/Cas 9] you can put a new gene into an organism, or you can tweak a gene and turn it on where it had been turned off, or turn it off where it had been turned on. The most important genes are regulatory genestheyre like generals that control hundreds of other genes, and so just by messing with one of them you could change entire swaths of what an organism looks like or how it behaves.

At the same time it turns out that there is a means of causing change that is not Darwinian. Lamarck is always ridiculed in evolution classeshes the guy that said that the reason giraffes have long necks is that giraffes would stretch their necks every day, and stretch and stretch and stretch, and all that stretching led them to produce babies with longer necks. Ha, ha, ha.

But in terms of behavior, it turns out that he wasnt as wrong as we think. Were finding more and more that, for instance, people who have gone through combat, or women who have been abusedwhen you have these horrendous episodes in life, it causes permanent change, which is then passed on to your kids. These are actual genetic shifts that are taking place within people. Its called epigenetics, and that too can cause huge evolutionary change.

On a larger scale, the amount of stress that Americans are going through now, because of Trumpthere is going to be an evolutionary consequence.

President of the World Futures Studies Federation, Adjunct Professor at the Institute for Sustainable Futures (University of Technology, Sydney) and author of The Future: A Very Short Introduction & Postformal Education: A Philosophy for Complex Futures.

Todays transhumanists claim that the only way for humans to have superhuman powers is through technological, biological, or genetic enhancement. The more extreme views of human-machine interface include cyborgs; Ray Kurzweils singularity the idea that human functioning can be technologically advanced exponentially until convergence; and Elon Musks neural lace, which merges the human brain with AI. All these ideas are still in the realm of science fiction, yet they are attracting hundreds of millions of dollars in funding.

Ironically, the idea of human beings evolving superhuman powers is not new. Friedrich Nietzsche wrote in 1883 about the bermensch translated as: Superman, Ultrahuman or Higher-Person. His ideas integrated Darwins biological evolution with the German Idealists writings on evolution of consciousness. Like Nietzsche, French philosopher Henri Bergson wrote in 1907 about the Superman arising out of the human being, in much the same way that humans have arisen from animals. In 1950, Teilhard de Chardin wrote about the Ultra-human or Trans-human, but his transhumanism was humanistic and spiritual, not high-tech.

Australian-based member of the Evolution, Complexity and Cognition group at the Free University of Brussels, author of The Evolutionary Manifesto and Evolutions arrow: the direction of evolution and the future of humanity.

A few random genetic mutations are incapable of producing new, highly complex capacities such as winged flight. It is as unlikely as it would be for a random earthquake in a medieval village to re-arrange everything to produce a modern city. This is because gene-based evolution proceeds largely through blind trial and error. The great majority of mutations will be harmful. Complex new adaptations can be discovered only through the accumulation of small advances over many, many generations. Billions of individuals must die as failed experiments in order to produce anything by trial and error that is complex and adaptive. In contrast, we can use our intelligent minds to narrow down the search and then try out targeted possibilities in our minds. It is a lot more efficient and acceptable to try out changes in our minds rather than by producing vast numbers of mutant individuals, nearly all of whom would die as failed experiments. As the great philosopher Karl Popper put it, our hypotheses die in our stead.

It is also highly implausible that super powers could be enabled by changes within the bodies of humans. The current laws of physics and chemistry do not seem to allow for mechanisms in flesh and blood that could enable, for example, individuals on different continents to communicate as effectively as they can be using smart phones. Certainly the typical super powers possessed by mutants depicted in movies seem inconsistent with the known laws of nature. At present they are the stuff of science fiction and are likely to always remain so.

PhD student, Ecology, Penn State University

I would say flight, mind control, telepathy [are the least plausible superpowers]. Im not even sure how mind control and telepathy could occur (although you could say mind control if you have particularly charismatic people paired with heavily suggestible people). Flight would require us reshaping our body beyond just getting wings. Wed need much better chest/back muscles, and, I believe, a shifting in our center of gravity, which would be long-coming and difficult. Night vision might be the easiest, though it also wont be easy or quick to come, just because our long ago ancestors were nocturnal.

Could a new kind of superhuman conceivably evolve alongside regular humans? If this new kind of super-mutated human is still the same species as us regular people, then I would think its more likely that the mutation is caused by a recessive gene (think your little n to a big N), and if theyre still breeding with us regular humans, youd end up with fewer pure mutants (nn), more carriers (Nn), and regular people (NN). Whether they live alongside us depends on the scenario.

Either way, this would take a ton of time, so I guess your best chance of having mutants and regular humans living together at the same time would be having mutants be the same species as humans, but something happens with a gene that causes phenotypic differences and can be carried.

Professor of Science Communication, School of Mathematics & Physical Sciences, University of Hull

Some superpowers are always going to stay firmly in the range of the fantastical; to quote Star Trek: you cant change the laws of physics. So speedsters such as The Flash and Quicksilver are never going to be able to consume enough food to power their supersonic runs. Similarly Johnny Storms ability to (reversibly) turn into superheated plasma must stay firmly in the realm of fantasy, it needs just too much energy.

However there are plenty of examples of superpowers in nature, so we know that these are at least biologically possible. Kestrel may have some version of telescopic vision, which is achieved by just packing more light sensitive cells into the retina. Bats have echo location, like that used by Matt Murdoch (as Daredevil). Plenty of animals have what we might call supervision because of their ability to see in UV. Then theres Magneto, who can sense and manipulate electro-magnetic fields. This isnt so far away from the abilities of electric eels, and even the humble pigeon can sense magnetic fields.

Assistant Professor, University of Saskatchewan

Theres tons of evidence in the fossil record that [new kinds of humans have evolved alongside regular humans] in the past, so I see no reason why that couldnt happen in the future.

We used to the think that there was a linear trajectory from our fossil ancestors to contemporary modern humans, but the more fossils that are discovered, the more evidence we have to suggest that there was not just an ancestral branch or tree, but more of an ancestral bush of fossil species which went off in various directions and then for whatever reasonwe still dont knowwent extinct. Were the only living relative around today, but we have lost different species that existed and lived next to each other in time, though not necessarily in space.

In terms of superpowers that we might evolve, or that I would like to seeit would build on what we already do. One side of the coin is that were incredibly gifted at killing each other.

The flipside of that is that were also incredibly good at taking care of each other, and that is the reason why I think weve thrived as a species, because were social, and we work together, and we cooperate. So as we enter into this really tense and tenuous part of our history, when were in the Anthropocene, and the climate is changing, Id really like to see us as a species, and globally as a community, develop our superpowers to go above our current level of empathy and compassion and imagination and ingenuity and really take them to heroic, comic book levels of innovation and policy-making and invention. We need to become our own heroes.

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Columbus Zoo’s polar bear cubs fight crime with their DNA – News … – The Columbus Dispatch

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Alissa Widman Neese The Columbus Dispatch @AlissaWidman

The Columbus Zoo and Aquarium polar bear cubs aren't just cute and cuddly.

They're also helping the federal government fight crimes against their wild relatives in the Arctic,thanks to advancements in forensic science and DNA testing.

The U.S. Fish and Wildlife Service's Forensic Laboratory in Oregon often relies on zoos to maintain its database of DNA samples from protected animal species. But when the Columbus Zoo sent DNA from its six polar bears to the lab in March, it came with payoffs for both parties including a confirmation of whether the zoo's three newest cubs are male or female.

The lab's scientists analyze evidence during investigations of violations of federal wildlife protection laws, including poaching, illegal trading of animals, theft of rare plants and creating products from endangered species.

For example, the lab could use DNA to identify a decaying carcass as a protected animal or confirm that a business is selling items made with bald eagle feathers or elephant ivory.

Scientists are trying to perfect a new, more accurate DNA test for bears and benefited from the Columbus Zoo's controlled samples from a known family of animals. The reference data illustrate how genetic patterns change in a population over time. It could someday pin down criminals who harm polar bears, which are protected by the Marine Mammal Protection Act and the Endangered Species Act, on which the bears are listed as threatened.

Only an estimated 20,000 to 25,000 polar bears are living in the wild, and there are just 40 or so bears in 27 U.S. zoos that are members of the Association of Zoos and Aquariums.

"Our polar bear database is fairly small, so the more samples we can get, the better," senior forensic scientistMary Burnham Curtis said.

The zoo, meanwhile, was seeking a non-invasive way to determine the sexes of its baby bears. Because the 6-month-old animals are being raised by their mothers and not hand-reared by zookeepers, staffers would have had to put them under anesthesia to examine their genitals and make an official determination.

"That seemed like an unnecessary risk for something that was just curiosity, not critical," said Randy Junge, the zoo's vice president of animal health.

"Luckily, we were able to help each other out."

Junge sent emails to diagnostic labs across the country seeking options, including the Fish and Wildlife forensic lab. Zoos work with the lab frequently to provide DNA samples to use as reference data the Columbus Zoo has provided samples of rhinoceros horn in the past, for example and some zoos serve as holding facilities for living animals that are considered evidence in ongoing criminal investigations.

Although the lab doesn't perform sex determination tests as a service to the public, its scientists are usually willing to work with zoos that provide DNA samples, Curtis said.

Columbus Zoo staff provided hair clippings and saliva swabs from all six of its bears.

Ultimately, test results confirmed what keepers suspected based on their observations: mother bear Anana's cub is female and mother bear Aurora's twin cubs are male and female.

Anana's cub was recently named Amelia Gray in an online naming contest. The twins were named Nuniq and Neva by zoo staff. Nuniq is a derivative of Nanuq, the name of all three cubs' father, who died in late April from liver cancer at age 29.

awidmaneese@dispatch.com

@AlissaWidman

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8News takes a closer look at state’s DNA database in light of Chesterfield conviction – WRIC

Posted: at 5:46 am

CHESTERFIELD COUNTY, Va. (WRIC) On Friday, 18-year-old Quaseer Carter pled no contest to the 2015 rape and beating of a 47-year-old woman. The states DNA database connected Carter as a suspect.

Its the latest success story involving DNA, which is why many have called for the database to be expanded.

A few months ago, the parents of murdered UVaA student Hannah Graham urged lawmakers to study expanding the number of misdemeanor crimes that require DNA collection. They say their daughter would still be alive had Jesse Matthew, the man convicted in her death, had his DNA collected for trespassing in 2010.

Hannah would never have met him and he would not have abducted and murdered her and simply put she would be alive today, said Hannahs mother, Sue Graham back in January.

While a measure requiring studying expansion failed, the states crime commission decided a few days ago it would study the issue. Effective July 1, 2015, nine misdemeanors were added to the list of crimes that require DNA collection.

The state has more than 415,000 DNA samples currently in its database. Thats up from the almost 6,000 the state had in 1995.

While supporters argue more DNA would help solve more crimes, some lawmakers and groups like the ACLU continue to cite concerns over personal privacy. They say there has to be a balance between protecting the public and civil liberties.

Meanwhile, Carter will face sentencing in September.

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DNA collection machine invented in Idaho looking for permanent home in Idaho – 6 On Your Side

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After spending 20 years in prison for a crime he didn't commit, Chris Tapp walked out of prison a free man in March.

The main contributing factor to his freedom, a machine called the M-Vac, a DNA collection machine that some are calling the latest and greatest technology in DNA especially for cold cases.

"We are working with stuff that should have been done if we would have had this technology a long time ago," said Francine Bardole, a senior crime scene investigator with the West Jordan Police Department.

The machine was invented in Jerome, Idaho, but ironically there are no systems in the state.

"Obviously we want to try to change that. I would love to see more systems up here, especially because I know it would help solve some of the crimes that I know can't be solved," said President and CEO of M-Vac Systems.

During a presentation, Thursday at BPD multiple crime agencies were in attendance just to learn more about the M-Vac, what it is, and how it works.

Bradley says knowledge is key in getting the system implemented.

"Agencies can't order the equipment or bring the equipment in and get it validated and everything else if they don't know about it," said Bradley.

While they said the M-Vac isn't a replacement for traditional swabbing of DNA and it doesn't work for every case, generally when it does help is where there are no other options available.

"These are things that law enforcement agencies need to know are available to them when they have reached a dead end," said Bardole. "You've got somebody roaming around victimizing the community, what is your next step? I say the M-Vac is your next step."

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Virginia teen identified as rape suspect through DNA – W*USA 9

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WUSA 2:39 PM. EDT June 05, 2017

DNA data is being increasingly sold by private companies. (Photo: PhotoDisc)

CHESTERFIELD, VA. (AP) - Virginia's DNA databank has identified a teen as the suspect of an October 2015 rape and beating of a 47-year-old woman.

Richmond Times-Dispatch reports the 18-year-old man pleaded no contest to the attack in Chesterfield Circuit Court on Friday.

The prosecution and defense reached a plea agreement after the teen's first trial on the rape and sodomy charges ended with a hung jury.

Chesterfield prosecutor Stephen Sharpe says the victim was walking and only a few houses away from the home of her ex-husband she'd been helping pack for a trip when a man asked her for a cigarette before sexually assaulting her.

The teen's sentencing is in September and he faces up to five years in prison. He's free on bond but remains electronically monitored with an ankle bracelet.

___

Information from: Richmond Times-Dispatch, http://www.timesdispatch.com

2017 Associated Press

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ASCO 2017: Comparison of somatic mutation profiles from cell free DNA versus tissue in metastatic urothelial carcinoma – UroToday

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Chicago, IL (UroToday.com) In this single-institution study, the authors aim to establish the feasibility of using next-generation sequencing (NGS) to analyze cell-free DNA (cfDNA), which represents DNA fragments released into circulation. While NGS has become an integral component of tissue analysis in the search for biomarkers, predictors and potential genetic causes of cancer, NGS on cfDNA is less well established. By analyzing cfDNA, the authors feel they can overcome the spatial and temporal limitations of tissue analysis.

To that effect, they proceeded to complete NGS on cfDNA of patients with metastatic urothelial carcinoma (mUC), and compared it to the genomic profile of tissue obtained in the clinical setting. As described in a prior abstract from the same group1, the MSKCC group utilized an established pipeline tool called MSISensor to evaluate NGS data from prospectively collected tissue, as part of the MSK IMPACT study, in which they target 341-468 genes. Both cfDNA and previously collected tissue were analyzed for somatic mutations, and the outputs were then compared.

In this proof of concept study, 26 pts were included. NGS analysis of cfDNA detected 1 somatic mutations (range 1-21) in 69% (18/26). For 15 pts, NGS data was available from archival tissue (11 primary tumors, 3 metastases, and matched primary/metastatic tissue in 1 case). The interval between cfDNA and tissue collection ranged from 35 days to > 4 yrs. Eleven patients (73%) received intervening treatment, including 47% (7/15) with chemotherapy, 67% (10/15) with immunotherapy, and 40% (6/15) with both. In 40% (6/15), cfDNA harbored alterations not found in archival tumor tissue.

Comparison of cfDNA and archival tissue In 73% (11/15), some mutations within archival tissue were not detected in cfDNA, including hotspot HER2 S310F and FGFR3 S249C mutations. Tumor and cfDNA mutation profiles were identical in 20% (3/15), with the tumor/cfDNA interval in this group ranging from 35 days to < 1.5 yrs. Somatic alterations including hotspot ERCC2 P463A and PIK3CA E545K mutations were detected in cfDNA from 3 pts where archival tumor tissue NGS failed. Thus, cfDNA identified new mutations in 50% (9/18) of pts for whom cfDNA identified somatic mutations and tissue NGS was previously attempted.

Limitations: 1. The time between collection of tissue and cfDNA ranged to > 4 years. It is possible that some discordance may be due to intervening treatments and mutations within the tumor itself. Identical mutation profiles were found in patients with shorter interval times.

Despite its limitation, this proof-of-concept study is important to establish a new potential source of tumor genomics. This may lead to new biomarkers and therapies for mUC. Further studies, preferably prospective with interval cfDNA collections, may help address some of the issues with the current study.

Presented By: Michael L. Cheng

Co-Authors: Catharine Kline Cipolla, Samuel Funt, Maria E. Arcila, Hikmat Al-Ahmadie, Jonathan E. Rosenberg, Dean F. Bajorin, Michael F. Berger, Dana Tsui, David B. Solit, Gopa Iyer

Institution(s): Memorial Sloan Kettering Cancer Center, New York, NY; Memorial Sloan-Kettering Cancer Center, New York, NY

Written By: Thenappan Chandrasekar, MD, Clinical Fellow, University of Toronto, Princess Margaret Cancer Centre Twitter: @tchandra_uromd

at the 2017 ASCO Annual Meeting - June 2 - 6, 2017 Chicago, Illinois, USA

Reference: Abstract 4511. Iyer G. Mismatch repair (MMR) detection in urothelial carcinoma (UC) and correlation with immune checkpoint blockade (ICB) response.

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Rice Genome Annotation Project

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February 6, 2013 A paper describing the unified Os-Nipponbare-Reference-IRGSP-1.0 pseudomolecules and MSU Rice Genome Annotation Project Release 7 has been published.

February 7, 2012 The GFF3 and brief info files were updated on the FTP site. The update corrects issues with the UTR feature type and several cases where the mRNA coordinates were incorrect. The sequence files and other features in the GFF3 files were not changed.

October 31, 2011 Release 7 of the MSU Rice Genome Annotation Project is available. This release is based on a new pseudomolecule assembly (Os-Nipponbare-Reference-IRGSP-1.0) made in collaboration with the Agrogenomics Research Center at the National Institute of Agrobiological Sciences, Tsukuba, Japan. This set of pseudomolecules unifies the previous MSU with the IRGSP/RAP effort. Genome browser has been updated with 81 tracks of data. Orthologous group analysis has been updated to include Zea mays release 5b filtered gene models.

We have planned server maintenance on the first Wednesday of every month. The Rice Genome Annotation Project web pages may be unavailable or only partially functional during server maintenance.

Feb 6, 2013 - A paper describing the unified Os-Nipponbare-Reference-IRGSP-1.0 pseudomolecules and MSU Rice Genome Annotation Project Release 7 has been published in the journal Rice.

The MSU Rice Genome Annotation Project Database and Resource is a National Science Foundation project and provides sequence and annotation data for the rice genome.

This website provides genome sequence from the Nipponbare subspecies of rice and annotation of the 12 rice chromosomes. These data are available through search pages and our Genome Browser that provides an integrated display of annotation data.

In cooperation with researchers at the Agrogenomics Research Center at the National Institute of Agrobiological Sciences, Tsukuba, Japan, we have prepared a final assembly of the rice pseudomolecules. These pseudomolecule sequences are now common to both the MSU Rice Genome Annotation Project and the Rice Annotation Project Database (RAP-DB)/International Rice Genome Sequencing Project. This effort was undertaken in order to allow researchers to easily compare annotations from both the MSU and RAP-DB projects. Gene loci, gene models and associated annotations created by MSU-RAP and RAP-DB were independently derived, but the pseudomolecules used by the two rice annotation projects to generated those annotations are now identical and can be easily compared. A manuscript describing the generation of the final rice pseudomolecule assembly is in preparation.

While many researchers utilize the MSU loci, gene models and transcripts in their own databases and genome browsers, these sites may have outdated annotation and may have modified or further annotated our official gene set. All MSU rice gene names are of the form LOC_Os##g##### as explained on our nomenclature page. MSU rice genes are created using de novo gene predictions from Fgenesh followed by improvements and/or modifications by the PASA program which uses other de novo gene prediction software and rice full length cDNA and EST alignments. Our gene set is constructed entirely "in house" and is not equivalent to annotation from RefSeq, RAP, SwissProt or UniProt. Because we can not guarantee that data that is labeled as MSU/TIGR genes at other websites are really our data, we suggest that users always refer back to the MSU Rice Genome Annotation Project for our genuine and current MSU rice gene data. Please note that while we can not prevent users from downloading our entire Genome Browser, we do not sponsor or approve of public re-display of our rice genome browser.

Researchers who wish to cite the Rice Genome Annotation Project website are encouraged to refer to our recent publication:

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The genome is out of the bottle: Embrace the possibilities – Healthcare IT News

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The last podcast in this series looks at current opportunities presented by advancements in Precision Medicine. How are healthcare organizations and patients learning to leverage the knowledge locked in our genes? And how can this knowledge become a real opportunity today?

Join Jennifer Girka, healthcare strategist within Dell EMCs Healthcare & Life Sciences division, as she provides an introduction to precision medicine. Girka is responsible for providing strategic insight to help Dell EMC advance its support of healthcare organizations, medical professionals and patients as they transform healthcare into the digital era. With more than 20 years helping to advance the healthcare industry with new opportunities and emerging technology, she works closely with healthcare customers and practitioners to bring them the right mix of technology innovation and solutions that will help them navigate through the ever-changing and increasingly complex world of healthcare.

Sources: To Adopt Precision Medicine, Redesign Clinical Care." NEJM Catalyst. February 5, 2017.http://catalyst.nejm.org/adopt-precision-medicine-personalized-health/ "Partners Data Lake Offers Healthcare Analytics as a Service." Health IT Analytics. March 17, 2016.http://healthitanalytics.com/news/partners-data-lake-offers-healthcare-analytics-as-a-service "Personalized Health Planning in Primary Care Settings." Fed Pract. 2016 January;33(1):27-34.http://www.mdedge.com/fedprac/article/105690/personalized-health-planning-primary-care-settings/page/0/1 Alice Park. "A Powerful New Tool for Editing the Human Genome." Time Magazine. April 4, 2016.http://time.com/4207612/a-scientist-gets-the-green-light-to-edit-the-human-genome/ City of Hope and Translational Genomics Research Institute combine to advance precision medicine and speed translational research.https://www.tgen.org/home/news/2016-media-releases/tgen-forges-alliance-with-city-of-hope.aspx#.WP9Y0dLyvIU

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CRISPR May Cause Hundreds of Unintended Mutations Into the … – Big Think

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In case you havent already heard of CRISPR-Cas9, it is the revolutionary gene-editing technology, discovered just a few years ago, that allows scientists to edit the DNA of any species with an unprecedented precision and efficiency. Today, thousands of researchers around the world are doing experiments with CRISPR, in the hope to cure us from genetic diseases and even deliver us designer babies. The first clinical trial to employ CRISPR-Cas9 is now underway in China, hoping to fight targeted cancers with modified immune cells.

The gene-editing method is based on the protective mechanism of bacteria against viruses. An RNA molecule carries segments of DNA from a previously encountered virus together with an enzyme (Cas9). Once the molecule encounters that same sequence of DNA, the enzyme gets activated and cuts it out. Researchers discovered that they can use this system to cut any DNA sequence at a precisely chosen location.

While the tool is touted for its precision, it is far from error free. Mutations do occur around the areas where the DNA has been cut and needs to be repaired. And sometimes CRISPR may hit unintended parts of the genome. Computer algorithms identify the most likely areas for these off-target mutations, which are later examined by researchers for deletions and insertions. However, whole-genome sequencing (WGS) - examining the entire DNA of living animals that had undergone gene editing - hadn't been done.

In a recently published study in the journal Nature Methods, titled Unexpected mutations after CRISPRCas9 editing in vivo scientists used whole-genome sequencing to study the mutations that had occurred in the DNA of mice that had undergone CRISPR gene editing.

Genetic Engineering and Biotechnology News reports that the investigators were able to determine that CRISPR had successfully corrected a gene that causes blindness, but found that the genomes of two independent gene therapy recipients had sustained more than 1500 single-nucleotide mutations and more than 100 larger deletions and insertions. None of these DNA mutations were predicted by computer algorithms that are widely used by researchers to look for off-target effects.

Co-author of the study Vinit Mahajan, M.D., Ph.D. said:

"We're still upbeat about CRISPR, we're physicians, and we know that every new therapy has some potential side effectsbut we need to be aware of what they are."

The authors are encouraging scientists to use the WGS method to determine all off-target effects of their CRISPR experiments.

In the last few days, however, some scientists have raised concerns about the validity of the study, questioning its methodology. Dr Gaetan Burgio, Group leader and head of the transgenesis facility at the Australian National University said in a Journal club review of the paper:

The claims over this paper are unsurprising as Cas9 enzyme could remain in the cells for days and create random indels in the genome. However, the main issues for me resides in the overestimation of the number of off target effects due to the lack of rigor in the experimental design to detect these unexpected mutations. In short my main point is these unintended mutation are likely to have preexisted prior to the injection of CRISPR system.

One thing is sure there is a lot more work to be done to ensure the safety of the CRISPR/Cas9 technology.

Photo Credit:Pixabay

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