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Category Archives: Transhuman News
Corn to remain ‘king’ of tomorrow’s crops – American Agriculturist
Posted: June 16, 2017 at 2:48 pm
Citified nonfarmers worry that corns germplasm is shrinking into a narrow genetic spectrum. To them, all corn looks the same and is controlled by corporate agriculture. And now the truth: Fear not.
Maize is grown around the world, and its genetics are highly adaptable to changing uses and environments. Thats the latest finding of new and much more detailed genome research, published online recently in Nature.
Our new genome for maize shows how incredibly flexible this plant is, a characteristic that directly follows from the way its genome is organized, explains Doreen Ware, USDA genetic researcher at New Yorks Cold Spring Harbor Laboratory. She led scientists at seven academic institutions and several genome technology companies in the gene mapping project.
The plants genomic DNA sequencing in its 10 chromosomes is very large and has a far wider phenotypic plasticity i.e., the potential range in its ability to adapt than even the human genome, she adds. That helps us understand why maize, and not some other plant, is today the most productive and widely grown crop in the world.
This flexibility helps explain why this plant species has been so successful since its adaptation by agriculturalists thousands of years ago. It also bodes well for its ability to grow in new places as Earths climate changes, and for increasing the plants productivity and global environmental sustainability.
Which genes are activated or silenced determines what the total set of genes enables a plant to do, Ware says. This new genome map is bringing to light how the plants genes are regulated in different individuals across the species.
By assembling a highly accurate and very detailed reference genome for the B73 maize line, then comparing it with genome maps for maize individuals from two W22 and Ki11lines grown in different climates, the sequencing team arrived at an astonishing realization.
Maize individuals are much, much less alike at the genome level than people are, points out Ware. The genome maps of two people will each match the reference human genome at around 98% of genome positions. Humans are virtually identical, in genome terms.
But weve found that two maize individuals from the W22 and Ki11 lines each align with our new reference genome for B73 maize only 35%, on average. Their genome organization is incredibly different!
This difference between maize individuals reflects not only of changes in the sequence of the genes themselves, but also where and when genes are expressed, and at what levels, explains Yinping Jiao, another Cold Springs researcher. He developed the first reference genome for maize in 2009, but acknowledges that its now outdated technology that yielded a genome text more akin to a speed-reading version than one fit for close reading.
A boon for corn breeders Current mapping technology sheds much more light on how those genes are regulated. Because of its amazing phenotypic plasticity, concludes Ware, so many more combinations are available to this plant. What does this mean to breeding? It means we have a very large variation in the regulatory component of most of the plants genes. They have lots of adaptability beyond what we see them doing now. That has huge implications for growing maize as the population increases and climate undergoes major change in the period immediately ahead of us.
The new genomes resolution of spaces between genes makes it possible to read detailed histories from the texts of genomes from different maize individuals. Consider, for instance, the impact of transposons bits of DNA that jump around in genomes. This can now be assessed with specificity not previously possible.
When transposons jump into a position within a gene, the gene can be compromised entirely, adds Ware. Other times, whether a transposon has hopped into a position just before or after a gene can determine when and how much it is expressed.
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Genomic analysis of liver cancer reveals unexpected genetic players – Medical Xpress
Posted: at 2:48 pm
June 16, 2017 Cancer cell during cell division. Credit: National Institutes of Health
Liver cancer has the second-highest worldwide cancer mortality, and yet there are limited therapeutic options to manage the disease. To learn more about the genetic causes of this cancer, and to identify potential new therapeutic targets for HCC, a nation-wide team of genomics researchers co-led by David Wheeler, Director of Cancer Genomics and Professor in the Human Genome Sequencing Center (HGSC) at Baylor College of Medicine, and Lewis Roberts, Professor of Medicine at the Mayo Clinic, analyzed 363 liver cancer cases from all over the world gathering genome mutations, epigenetic alteration through DNA methylation, RNA expression and protein expression. The research appears in Cell.
Part of the larger Cancer Genome Atlas project (TCGA), this work represents the first large scale, multi-platform analysis of HCC looking at numerous dimensions of the tumor. "There have been large-cohort studies in liver cancer in the past, but they have been limited mainly to one aspect of the tumor, genome mutation. By looking at a wide variety of the tumor's molecular characteristics we get substantially deeper insights into the operation of the cancer cell at the molecular level," Wheeler said.
The research team made a number of interesting associations, including uncovering a major role of the sonic hedgehog pathway. Through a combination of p53 mutation, DNA methylation and viral integrations, this pathway becomes aberrantly activated. The sonic hedgehog pathway, the role of which had not been full appreciated in liver cancer previously, is activated in nearly half of the samples analyzed in this study.
"We have a very active liver cancer community here at Baylor, so we had a great opportunity to work with them and benefit from their insights into liver cancer," Wheeler said. Among the many critical functions of the liver, hepatocytes expend a lot of energy in the production of albumin and urea. It was fascinating to realize how the liver cancer cell shuts these functions off, to its own purpose of tumor growth and cell division.
"Intriguingly, we found that the urea cycle enzyme carbamyl phosphate synthase is downregulated by hypermethylation, while cytoplasmic carbamyl phosphate synthase II is upregulated," said Karl-Dimiter Bissig, Assistant Professor of Molecular and Cellular Biology at Baylor and co-author of the study. "This might be explained by the anabolic needs of liver cancer, reprogramming glutamine pathways to favor pyrimidine production potentially facilitating DNA replication, which is beneficial to the cancer cell."
"Albumin and apolipoprotein B are unexpected members on the list of genes mutated in liver cancer. Although neither has any obvious connection to cancer, both are at the top of the list of products that the liver secretes into the blood as part of its ordinary functions," explained Dr. David Moore, professor of molecular and cellular biology at Baylor. "For the cancer cell, this secretion is a significant loss of raw materials, amino acids and lipids that could be used for growth. We proposed that mutation of these genes would give the cancer cells a growth advantage by preventing this expensive loss."
Multiple data platforms coupled with clinical data allowed the researchers to correlate the molecular findings with clinical attributes of the tumor, leading to insights into the roles of its molecules and genes to help design new therapies and identify prognostic implications that have the potential to influence HCC clinical management and survivorship.
"This is outstanding research analyzing a cancer that's increasing in frequency, especially in Texas. Notably, the observation of gene expression signatures that forecast patient outcome, which we validate in external cohorts, is a remarkable achievement of the study. The results have the potential to mark a turning point in the treatment of this cancer," said Dr. Richard Gibbs, director of the HGSC at Baylor. The HGSC was also the DNA sequence production Center for the project.
Wheeler says they expect the data produced by this TCGA study to lead to new avenues for therapy in this difficult cancer for years to come. "There are inhibitors currently under development for the sonic hedgehog pathway, and our results suggest that those inhibitors, if they pass into phase one clinical trials, could be applied in liver cancer patients, since the pathway is frequently activated in these patients," added Wheeler.
Explore further: Study identifies a role for the metabolism regulator PPAR-gamma in liver cancer
More information: Adrian Ally et al. Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma, Cell (2017). DOI: 10.1016/j.cell.2017.05.046
Journal reference: Cell
Provided by: Baylor College of Medicine
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Liver cancer has the second-highest worldwide cancer mortality, and yet there are limited therapeutic options to manage the disease. To learn more about the genetic causes of this cancer, and to identify potential new therapeutic ...
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Genomic analysis of liver cancer reveals unexpected genetic players - Medical Xpress
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Hacking the human lifespan – Boing Boing
Posted: at 2:47 pm
Biomedical gerontologist Aubrey de Grey has said that the first person likely to live to 1,000 years-old has probably been born already. de Grey's nonprofit lab, and others, some of which are funded by Silicon Valley billionaires, are boldly focused on how science may find a cure for aging. In the new issue of Smithsonian, Elmo Keep writes about these efforts to "hack" mortality and quotes my Institute for the Future colleagues Rachel Maguire and Jake Dunagan, both of whom cast a concerned eye on the obsession with longevity. From Smithsonian:
One thing we do know is that there are more elderly people alive now than there have ever been in the history of the planet. Even if todays life-extension researchers made meaningful breakthroughs, the therapies wouldnt be available for many years to come. That means were about to face a lot of death, says Rachel Maguire, a research director focusing on health care at the Institute for the Future, in Palo Alto. By 2025 or 2030, there will be more of a culture of dying and lots of different ways of experiencing it. There are early signs of new types of funerals and spiritual formations around this. Maguire foresees new end-of-life plans, including assisted dying. When it comes to aging, she points out that biological research is only one piece of a puzzle that must also include economics, politics and cultural change. I dont think we have answers yet for how wed do the other pieces. And the financial piece alone is huge.
Theres already a huge disparity between the life spans of rich and poor Americans, and critics of the new longevity research worry the gap may only grow wider. A 2016 report from the Brookings Institution found that, for men born in 1920, there was a six-year difference in life expectancy between men at the top 10 percent and bottom 10 percent of the earnings ladder. For men born in 1950, the difference was 14 years. For women, the gap grew from 4.7 to 13 years. In other words, advances in medicine havent helped low-income Americans nearly as much as their wealthier counterparts....
Dunagan has little patience for Silicon Valleys longevity research; he says proponents are not sufficiently interested in the details. The rich people are defining the terms of the longevity conversation and have enhanced access to these technologies, he says. Everyone wants to live longer, to some degree, but its also the sense of privilege, of selfishness to it thats I want mine. I always want mine. Well, what if everyone had this? What would be the long-term implications of that?
Derek Muller of the YouTube channel Veritasium uses a nifty trick to make visible the invisible air currents, temperature gradients, and differences in air pressure around us. The process is called Schlieren photography and with the right equipment and some precision alignment, you can try it at home. As Muller explains: I first saw a []
On June 16, 1963, Soviet cosmonaut Valentina Tereshkova became the first woman in space. She orbited the Earth 48 times over a period of three days. Inspired by Yuri Gagarin who in 1961 became the first person in space, Tereshkova applied to the Russian space program and was accepted based on her extensive background as []
In this nifty YouTube video, Dave Hax talks through the properties of gallium, the metal that liquefies at just 86F and is safe to play with. (Just dont eat it!) Hax has a whole collection of videos about gallium on his YouTube channel. If you want to give it a try yourself, you buy 20 []
While the portability of smartphones and tablets is undeniably convenient, the occasional need to support your device while typing or video chatting can get exhausting after awhile. To give you an extra hand with your mobile devices, this trio of foldable stands is availablein the Boing Boing Store.These device props have an adjustable metal back, []
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Having grown out of its awkward adolescence, JavaScript is no longer a novelty language for animating elements on webpages. It has become the lingua franca of the web, imbued with a variety of other libraries and tools to form complex, interactive sites. To make a real career as a programmer its not enough to just []
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Eczema Overview, Symptoms and Treatment – Health.com
Posted: at 2:46 pm
Jump to: Types | Symptoms | Causes | Pictures | Diagnosis | Treatment | Medications | When to see a doctor | Eczema in babies | Is it contagious? |
Because eczema is often used as an umbrella term for a group of chronic, itchy skin rashes, a simple definition of the skin condition is hard to come by. Many people with eczema develop dry, itchy, red patches of skin. In some forms of eczema, blisters develop. Scratching can inflame the rash and cause weeping of clear fluid. Over time, the affected patches of skin can thicken. Eczema can look different depending on the type of rash and where it appears on the body. Symptoms typically flare up for a period of time and then calm down before surfacing again. More than 30 million Americans have some form of eczema. While the exact cause is unclear, a combination of factors, such as genes, environment, and immune system are thought to play a role.
Atopic dermatitis is the most common form of the skin condition, and its usually what people are referring to when they talk about eczema. About one in five children develop atopic dermatitis, often in infancy and usually by age 5. (Only a small percentage of adults develop this type of eczema.)
Dry, scaly, red, and itchy patches can appear on the face, scalp, hands, or feet; inside the elbows; or behind the knees. In more severe cases, these patches crack and crust over, and they can become infected. Atopic dermatitis comes and goes, with periods when symptoms are worse and other times when the rash goes into remission and disappears. It tends to occur in families with a history of this eczema, hay fever, or asthma. It can be a lifelong condition, although some children outgrow it or see symptom improvement as they age.
With this type of eczema, itchy, fluid-filled blisters develop under the skin on the hands or the feet, especially palms, soles, or sides of the fingers. Patches of flaky, red skin can develop. Over time, the affected skin can become thick and cracked.
Dyshidrotic eczema (also called pompholyx) may be aggravated by stress or frequent or long periods of contact with water. Working with certain metalssuch as chromium, cobalt, or nickelcan trigger symptoms. It is more common in women, and there is a higher risk if you have had atopic dermatitis (eczema) or allergic rhinitis (hay fever). It tends to occur in spring and summer and in warmer climates.
Round or oval areas of itchy, inflamed sores are the hallmark of this type of eczema, which is also called nummular dermatitis or discoid eczema.
Clusters of tiny pimples form plaques, or patches, that become scaly. One or more areas of the skin, usually on the arms and legs, can be affected. It is more common in older males, but young women can get it, too. Nummular eczema tends to occur in people with dry skin, especially in winter. Like other types of eczema, symptoms can come and go. New patches may form where there was injury to the skin (such as an insect bite). Keeping skin moisturized can help prevent future flare-ups.
RELATED: What The Night Of Gets Right (and Wrong) About Eczema
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How do you know a rash is eczema and not psoriasis or another skin condition? Eczema is usually accompanied by uncontrollable itching that worsens when you scratch it and can interfere with sleep. People sometimes scratch until they bleed, yet itching persists, and the wound becomes vulnerable to infection.
The signs and symptoms of eczema can vary from one person to the next.
Atopic dermatitis, the most common type of eczema, usually strikes in childhood. Babies tend to develop a red rash on their cheeks and scalp that turns dry and scaly. The rash can bubble up, ooze, and crust over. In young children, other body sites may be affected, such as the inside folds of the elbows or knees, or the hands, wrists, or feet. Over time, these patches can lighten or darken, and they may become thick and bumpy and constantly itchy.
Dyshidrotic eczema typically strikes the hands and feet. People with this type of eczema develop small, fluid-filled blisters that itch and burn. The blisters weep, crust over, and crack, exposing the skin to painful infection.
Nummular eczema produces pimples or blisters that leak fluid and form crusty, coin-shaped patches on the legs, arms, hands, feet, or torso. It occurs more often in the winter months.
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While the exact cause of eczema is unknown, scientists believe its a product of your genes and the environment. Eczema risk is greater in children whose parents had eczema or a condition like asthma or hay fever.
Usually the skin serves as a shield against toxins, bacteria, and allergens. With eczema, that protective barrier dries out and is easily breached by irritants in the environment. Exposure to household products (such as soap, detergent, or fragrances) or to allergens (dust, pollen, or pet dander) may trigger eczema symptoms.
Other factors that may cause asthma symptoms to flare include stress and anxiety; cold or dry weather; dust, sand, or pollution; and wearing wool or synthetic fibers.
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Eczema typically produces a red, itchy, scaly rash, but exact symptoms can differ from person to person. What eczema looks like may depend on the type of eczema. Eczema rash can affect different body parts, from the scalp to the toes. Some people may develop a patch or two of inflammation, while others have multiple lesions. Eczema symptoms can range from mild to severe.
Atopic dermatitis, the most common type of eczema, usually begins in infancy or childhood. The first sign of eczema in babies is often red cheeks. In children, eczema usually appears in the inner folds on the elbows and knees. Dyshidrotic eczema is more common in young adults. It produces fluid-filled blisters on the hands and feet. Older men are more likely to develop nummular eczema, which produces distinctive circular or oval patches of blistered, scaly rash.
A red, itchy rash across the cheeks and chin is often the first sign of atopic dermatitis (eczema) in infants. Eventually, the rash begins to ooze and crust over, and drooling can worsen symptoms. Eczema rash may improve or disappear as children get older, although some people continue to experience flare-ups as adults. Treatment for mild eczema on the face may include topical ointments or creams as well as moisturizers.
Dry, chapped, and itchy skin on the hands that doesnt improve with moisturizer may be a sign of hand eczema. Symptoms can include red, itchy, inflamed skin with blistering that can lead to oozing, crusting, and cracking. People who have their hands in water all day or work closely with irritants such as detergents or solvents are more likely to develop this type of eczema. If you had atopic dermatitis as a child, you may also have a higher risk of developing hand eczema. Applying a cream after washing hands or wearing gloves may help protect hands from future flare-ups.
Eczema in babies can spread to other body parts, including the scalp. It is red, itchy and crusty. This is different from cradle cap (also known as seborrheic dermatitis), which produces redness and white or yellow flakes on the scalp. Treatment for scalp eczema may include a topical ointment applied to the rash.
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Theres no single test for diagnosing eczema. Your doctor or your childs pediatrician will conduct a physical exam. Some patients may be referred to a dermatologist or allergist. Doctors look for typical signs and symptoms of eczema, such as itching and rash.
The difficulty is often ruling out other conditions that cause irritating skin symptoms. Atopic dermatitis, for example, may be confused with seborrheic dermatitis (a common condition that mainly affects the scalp), while nummular eczema may resemble ringworm (a contagious fungal infection). Sometimes a skin patch test or allergy test may be required to confirm an eczema diagnosis by ruling out other conditions.
Expect your doctor to ask about your family history of allergic disease, since eczema can run in families. Kids with eczema can also go on to develop food allergy, hay fever (also known as allergic rhinitis), and asthmausually in that order (this is sometimes called the atopic march).
Tell your doctor when symptoms first appeared, how often you or your child experiences symptoms, other body parts that are affected, whether the problem comes and goes, and when it seems to flare up. Your doctor may ask about any allergies you or your child have and potential triggers of symptoms.
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Unfortunately, theres no single magic bullet to get rid of eczema. But there are a number of treatments and strategies for relieving symptoms, reducing inflammation, and preventing flare-ups. These include ointments and creams that are applied to the skin, oral antibiotics or antihistamines, and an injectable medication.
Restoring moisture is crucial for preventing symptom flare-ups. Soaks and wet wraps can soothe pain and itching. Prescription and over-the-counter moisturizers can help repair dry skin and keep it hydrated.
Steroid ointments and creams have long been the go-to remedy to clear up eczema rash. These topical treatments (also called corticosteroids) can help reduce inflammation and alleviate symptoms during a flare-up. But they are not recommended for long-term use due to serious potential side effects. Topical steroids come in different strengths, so if one doesnt do the job, your doctor may switch to a more potent version.
Newer non-steroidal medicines called calcineurin inhibitors are another option. These drugs include Elidel (pimecrolimus) cream for mild-to-moderate eczema and Protopic (tacrolimus) ointment is approved for moderate-to-severe symptoms.
Eucrisa (crisaborole) ointment 2% is another option for eczema patients 2 years old and older. Approved by the U.S. Food and Drug Administration in December 2016, Eucrisa inhibits an enzyme that promotes inflammation.
The newest weapon against eczema, approved in March 2017, is Dupixent (dupilumab) for adults with moderate-to-severe atopic dermatitis. It is administered as an injection under the skin and is intended for people whose eczema is not controlled by topical therapies or for whom topical treatment isnt recommended. The active ingredient in Dupixent is an antibody that blocks a protein that causes inflammation.
Light therapy (also called phototherapy) using a special device that emits ultraviolet light is an option for clearing difficult-to-treat eczema and rashes that are dispersed across the body.
Topical products containing coal tar or antihistamines may be prescribed for itch relief.
An antibiotic may be given to treat bacterial skin infections. Diluted bleach baths are sometimes used to treat baby eczema that results in frequent infections. (Be sure to consult your doctor first for specific instructions.)
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If you suspect eczema, see a doctor who can diagnose the condition and recommend treatments to heal the rash and prevent future flare-ups.
Eczema requires a lot of self-care. Youll need to recognize and avoid triggers, including allergens and other skin irritants. Keeping skin moisturized and avoiding temperature extremesheat that makes you sweat or low humidity that zaps the skin of moisturemay be important strategies for managing eczema.
There might be times when you or your child must seek additional advice and follow-up care. Consult your doctor about making dietary changes if your or your childs symptoms, medical history, and diagnostic testing suggest that food allergies may be an eczema trigger. You should also see a doctor right away if signs of infection are present. Patches of eczema with yellow crusting or pus-filled blisters, or areas around the patches that are red, hot, swollen, and painful may signal that skin is infected.
Report any change in the severity of eczema symptoms. And if a prescribed treatment doesnt seem to be working, contact your doctor about adjusting your medication.
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Atopic dermatitis, the most common type of eczema, often develops before age 1, and 90% of people who have it get it by age 5, reports the American Academy of Dermatology.
Baby eczema can look different from eczema in children or adults. In the first six months of life, babies may develop red, oozing rashes on the scalp and face, especially the cheeks, chin, and forehead. Later in infancy, eczema rash can pop up on elbows and knees.
To manage baby eczema, it is important to know what may trigger a flare-up of symptoms. Common triggers include pollen, pet dander, dust, smoke, soap, shampoo, certain foods, infection, and wool or synthetic fabric.
Having a good bathing and moisturizing routine can keep your babys skin hydrated. Heres what the American Academy of Dermatology recommends:
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Eczema is not contagious. You cannot get it from someone or spread it to other people. Although scientists dont know exactly what causes eczema, the current thinking is that its your genes and the environment that set the stage for the condition.
However, having eczema may expose the skin to bacterial, viral, or fungal infections, which can spread to other parts of the body or to others through skin-to-skin contact.
Dry, cracking skin creates an entryway for foreign invaders. Scratching itchy eczema patches can also introduce infection. In either case, when infection sets in, eczema can worsen and become more difficult to treat.
Fever, oozing, and pus-filled blisters may be signs of infection.
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7 Skin Self-Care Strategies Everyone With Eczema Should Be Doing – Health.com
Posted: at 2:46 pm
Eczema is incredibly common, and about30 million people in the United States are affected by some form this frustrating skin condition. Butit's not always so easy to understand how to care for your eczema. When so many substancesmay trigger an eczema flare(the long listincludes certain fibers, scented detergents, pollen, pet dander, and much more)how do you deal?
There are multiple types of eczema, but the condition is generally characterized by a red, itchy,inflammatory skinreaction, saysJoshua Zeichner, MD, a dermatologist and Director of Cosmetic and Clinical Research at Mount Sinai Hospitals Department of Dermatology. "Eczema is a condition in which the skin cannot protect itself from the environment and, as a result, becomes inflamed," he says. "The outer skin layer develops microscopic cracks in it and loses hydration, leading to disruption of the skin barrier."
While your doctor may have more tailored advice based on the type of eczema you have and your specific symptoms, Dr. Zeichner says one of thebest ways to ease symptoms ofeczema is to improve hydration and reduce inflammationboth of which start with great self-care. Here, dermatologists explain exactly how to care for your sensitive eczema skin at home.
RELATED: 10 Home Remedies for Eczema
A person with normal skin might get by moisturizing their skin every so often, but people with eczema likely need toslather on lotion a lot more often, perhaps as much as multiple times a day. "While some areas of the body may develop rashes, all of the skin may be dry and weak because of genetics if you have eczema," Dr. Zeichner explains. "While we cannot change your genes, we can compensate for them." He suggests looking for a body moisturizer that contains ingredients like petrolatum, such asVaseline Intensive Care Advanced Repair Unscented Lotion ($9; walmart.com), which will form a protective seal over the outer skin layer to prevent water loss and help the damaged skin barrier repair itself.
You might enjoy extremely hot showers, but your eczema skin does not. "Hot water can strip the skin of essential oils, and the longer the exposure, the worse off we are,"Dr.Zeichner says. "Stick to short showers of less than 10 minutes, with lukewarm water." He adds that "lukewarm" means that watershould be around the temperature you might expect from a heated pool.Test it before you step in; if the water feels hot immediately as it touches your skin, lower the temperature.
"Oil-based products are the best way to add moisture back into the skin and create a barrier to retain it," says Dendy Engelman, MD, a dermatologic surgeon at Medical Dermatology & Cosmetic Surgery Centers in New York City. She's an advocatefor the "soak and grease" method:"I use a two-step process, an in-shower oil and lotion, followed by lotion to trap moisture in." Apply your out-of-shower lotion or oil immediately after stepping out.
Your skin needs extra TLC, so Dr. Zeichner recommends the most sensitive sunscreens to protect yourself from harmful (and drying) rays. "Especially if you have sensitive skin or eczema, your skin may be more at risk from allergies or irritation from the sunscreen ingredients," he explains. "While baby sunscreens are designed with kids in mind, they are effective in adults, as well, and may be appropriate for people with dry, irritated skin." Dr. Zeichner says baby sunscreens typically only contain mineral-based ingredients, which are less likely to aggravate your skin.A good pick:Neutrogena Pure and Free Baby Sunscreen SPF 60+ ($12; target.com).
Many soaps and body washeshave harsh ingredients thatcan disrupt the skin's barrier, or scents that may aggravate eczema symptoms.Instead, Dr. Zeichner recommends choosingcleansers that contain gentle ingredients, such as colloidal oatmeal. Hes a fan of Aveeno Daily Moisturizing Body Wash ($15 for 2; amazon.com).
Another option: Dr. Engelmanrecommends Cetaphil RestoraDerm($19; target.com). And as a general rule, "[a]void harsh soaps with fragrances, glycolic acid,salicylic acid, and retinols that can further irritate the skin by drying them out," she says.
People with eczema may want to invest in a good humidifier, especially during the drier winter months. "Arid environments can put stress on already dry skin," Dr. Zeichner says. "A cool-mist humidifier in your bedroom will add moisture to the air, so your skin does not have to work as hard to maintain hydration." Why cool mist? Dr.Zeichner says this type of humidifier is safer than a hot-steam model, which can burn your skin if you get too close to it.
If you're takingultra-gentle care of your skin and your eczema symptoms are still impacting your daily life, see a dermatologist. A dermatologist can help you pinpoint the exact cause of your eczema, as well as suggest stronger treatment options that may help ease symptoms."There are a variety of prescription barrier-repair creams and new medications, both topically and systemically, that can treat this condition," says Dr. Zeichner.
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Study casts doubt about link between eczema, cardiovascular disease – Medical Xpress
Posted: at 2:46 pm
June 16, 2017 Micrograph of a heart with fibrosis (yellow) and amyloidosis (brown). Movat's stain. Credit: Nephron/Wikipedia
For the roughly 7 percent of adults who live with atopic dermatitis, a common form of eczema, a new study reports a little good news: Despite recent findings to the contrary, the skin condition is likely not associated with an increase in cardiovascular risk factors or diseases.
"In our study, people who reported having atopic dermatitis were not at any increased risk for high blood pressure, Type 2 diabetes, heart attacks or strokes," said lead author Dr. Aaron Drucker, an assistant professor of dermatology at the Warren Alpert Medical School of Brown University and a physician with the Lifespan Physicians Group.
The findings appear in the British Journal of Dermatology.
Drucker and a team of co-authors made the findings by analyzing the records of 259,119 adults aged 30-74 in the Canadian Partnership for Tomorrow Project. Drucker led the data analysis with the hypothesis, suggested by two recent studies, that people with atopic dermatitis (AD) would be significantly more likely to have various cardiovascular problems.
Instead, he found that the opposite was the case.
A diagnosis of AD was associated with somewhat reduced risk of stroke (0.79 times the odds), hypertension (0.87 times), diabetes (0.78 times) and heart attack (0.87 times). Drucker emphasized, however, that he does not believe that AD is protectivegiven the mixed evidence accumulated by researchers, the best conclusion is that AD is likely not positively associated with cardiovascular disease.
"It's important to make this clear so it doesn't get misinterpreted: Even though we found lower rates of these outcomes with atopic dermatitis, we are not interpreting that as atopic dermatitis decreasing the risk," he said.
The findings are based on a statistical analysis that accounted for confounders including age, gender, ethnic background, body-mass index, smoking, alcohol consumption, sleep, physical activity and asthma.
The suspicion that AD might be associated with cardiovascular disease has likely arisen from the better-substantiated association researchers have found between the skin condition psoriasis and cardiovascular disease, Drucker said. But while the two inflammatory skin ailments share some clinical similarities, he said, they work differently at the molecular level, which might explain why only one may be associated with cardiovascular disease.
"In response to the increased risk of cardiovascular disease discovered for psoriasis, clinicians and psoriasis patients have been encouraged to more actively screen for and manage cardiovascular disease," Drucker said. "It appears that similar measures may not be warranted for atopic dermatitis."
Drucker acknowledged that the study could not answer the question of whether AD severity might correlate with cardiovascular disease. He said he is pursuing that question in new research, though there is a paucity of datasets that include both severity information and cardiovascular disease diagnoses.
Explore further: Vitamin D levels not linked to asthma or dermatitis
More information: British Journal of Dermatology (2017). DOI: 10.1111/bjd.15727/full
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There's a typical "career" for some allergic people, and it starts very early on the skin: babies develop atopic dermatitis, food allergies may follow, then comes asthma and later on hay fever. A group of scientists led by ...
Scientists at the University of Notre Dame have found that exposure to just 10 minutes of light at night suppresses biting and manipulates flight behavior in the Anopheles gambiae mosquito, the major vector for transmission ...
An international team of scientists has identified several genetic mutations that, should they arise, could potentially allow the avian influenza strain H7N9 to spread between humans. The findings are published in PLOS Pathogens.
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Urinary tract infections (UTIs) are among the most common infections, and they tend to come back again and again, even when treated. Most UTIs are caused by E. coli that live in the gut and spread to the urinary tract.
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Precision medicine: Hype today but the promise is even bigger than we think – Healthcare IT News
Posted: at 2:44 pm
Precision medicine is far more hype than reality right now but, at the same time, the incredible potentialit holds for the future is even greater than all the buzz teases today.
Thats what I came away with from the Precision Medicine Summit in Boston this week.
Lets look into the distant future: A patient walks into a hospital to meet with clinicians who run tests and pinpoint a biomarker for, say, Alzheimers. Then a gene surgeon does some on-the-spot genome editing. The patient walks out with that Alzheimers-free-for-life feeling.
Primary care andgenome sequencing will come to the forefrontto identify which patients can benefit in a future where genome editing is widespread, said Ross Wilson, principal investigator at the University of California Berkeleys Institute for Quantitative Biosciences.
Just how widespread can precision medicine get? Well, Eric Dishman, who spearheads the NIHs All of Us program said the program is starting off with the goal of attracting 1 million American participants but is already thinking about how toscale that into the billionsglobally.
Getting genomic data into an EHR The grand vision is to democratize research and apply more brainpower per problem to the most vexing medical issues.
Before we can get there, though, a lot has to happen to hammer out data gathering and sharing capabilities, retool the healthcare system so its much more adaptable to change and ultimately modernize IT infrastructure to support precision medicine and all the data that entails.
Robert Green, MD, a medical geneticist and physician-scientist at Brigham and Womens Hospital and Harvard Medical School predicted skirmishes,if not all-out war, over genetic and genomic screening practices: with clinicians and patients on one side, calling for as much information as they can possibly get, versus public health officials and others, warning about the unforeseeable consequences of over-screening.
Among the reasons that people are refusing to participate in genetic testing is fear of discriminationby life, disability or long-term care insurance companies, according to Mayo Clinic Department of Laboratory Medicine and Pathology attorney Sharon Zehe. She added that the whole scenario puts providers in an awkward position because even among patients who are willing to undergo screening, many dont want that data to live in their medical records.
Not that getting genetic data into a medical record is exactly easy. One of the fascinating accounts at the conference was Washington University genetics fellow and bioinformaticist Nephi Walton explaining how it took nine months working with Epic to include genetic results into the EHR. You can make a human in that time, Walton said to laughter from the audience as he turned to a slide with a baby picture.
Precision medicine architecture emerging While its true that todays EHRs and IT infrastructure are not ready for the big data needs of precision medicine and I saw that thesame thing is true about population healthlast month at least one architecture is emerging.
Indeed, the strategy of harnessing FHIR standards, with mobile phones as middleware and a common data repository outside the EHR, is an apt way to manage the demands of precision medicine, said John Halamka, MD, CIO of Beth Israel Deaconess Medical Center. The idea is to maximize what patients already have in their homes.
That approach also gives patients more controlover who can and cannot share their data, including researchers, which India Hook-Barnard, director of strategy and associate director of precision medicine at University of California, San Francisco, said it is both the right thing to do and sound science.
But even the architecture Halamka described and giving patients more control over data sharing will not conquer all precision medicine challenges, of course. Michael Dulin, MD, director of the academy for population health innovation at the University of North Carolina Charlotte said simply dumping a whole heap of genomic data on top of the already broken healthcare system, replete with huge variances and medical errors, may actually yield worse outcomes than we have today.
We have to use technology, we need AI, Dulin said. We cannot do this without it.
Walton noted that first we need simple artificial intelligence and machine learning algorithms just to clean up healthcares messy data so its suitable for more sophisticated AI tools.
Precison medicine becomes precision health What was perhaps the boldest prediction to emerge from the conference came from Bryce Olsen, global strategist for Intels Health and Life Sciences unit: Patients will start asking for precision medicine in the second half of 2017 though many of them will not even realize what theyre requesting.
Patients are going to demand that doctors get a better understanding of underlying drivers of disease and defects in their tumor. Were going to see this for cancer first, Olsen said. Doctors that dont have good answers will see patients bounce.
Ill add one more to the mix: Precision medicine, in both term and concept, will be supplanted by the phrase precision health and, yes, this is distinct from how Im seeing digital health become digital medicine.
Precision health, said Megan Mahoney, chief of primary care in Stanfords population health division, is a fundamental shift to a more proactive and personalized approach that empowers people to live healthy lives.
Twitter:SullyHIT Email the writer:tom.sullivan@himssmedia.com
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Scientists Find Genetic Mutation That Could Increase the Male Lifespan – Gizmodo
Posted: at 2:44 pm
Jiroemon Kimura, the oldest man ever (Image: YouTube/Screenshot)
Professor S. Jay Olshansky once told Gizmodo, In the world of aging sciences, if you want to live a long life, choose long-lived parents. So genetic markers linked to longevity are interesting as hell. But if youve got the wrong genes, then the wrong moves might do you in.
A team of researchers from universities in the United States wanted to figure out the role of genetics in human lifespan, specifically relating to growth hormone. The researchers work shows two main things: first, that a mutation in mens DNA relating to growth hormone might lead to a longer lifespan. And secondly, that treating older people with growth hormone might be dangerous if they dont have the variation.
Gil Atzmon, the studys principal investigator from Albert Einstein College of Medicine and the University of Haifa in Israel, was most excited by how a slight change in DNA could have such a big impact. Delete a few base pairs, and you still have a functional protein that now makes people live longer, he said. I think this is phenomenal.
This is complex, so Im going to take it slow and possibly oversimplify things. Basically, theres one system in question, the IGF-1/GH axis. Each of these are genes that code for different molecules in your body.
Researchers have already had a hunch that IGF-1 can regulate height at the expense of longevity, like the case in dogs. More IGF-1 means taller but shorter lifespan and less IGF-1 means shorter but longer lifespan. This should make senseits akin to the way big dogs live shorter lives than small dogs.
The researchers studied 800 men and women from across four populations and found something surprising. Indeed, the IGF-1 levels were lower in the centenarians, but many of the men were also taller. The data showed the researchers that theres more than just IGF-1 at play.
Centenarian males were often missing a specific snippet of DNA in their GHR gene. These people seem to be more sensitive to growth hormone and grow taller. So, even though their IGF-1 levels were lower (they lived longer), they still grew taller from their special GH gene. The people with this mutation seemed to live ten years longer, on average.
And the study really was huge. The replication across the four different populations makes our result more accurate and globally translated.
Atzmon himself admitted that all this is pretty complex. But its definitely new, important evidence pointing to the role that this IGF-1/GH axis plays in simultaneously determining your height and your lifespan, explained Andrzej Bartke, Professor of Physiology and Internal Medicine at Southern Illinois University School of Medicine, in a conversation with Gizmodo.
But were not at some level of life-hacking clarity. Clearly more research is needed to understand exactly why this type of GH receptor favors extreme longevity, why the effect was seen only in men and why the results in people studied by these investigators differ from some of the previous findings in different groups of human subjects with the same type of receptors, said Bartke.
Theres a catch to all this. Their results seemed to show that folks who dont have the GH variation might actually be sensitive to growth hormone therapy. This is a stark reminder that administering growth hormone as an intervention to slow agingwhich is still being done in the anti-aging medicine industry is not warranted by the scientific literature, Olshansky told Gizmodo. In fact, could actually be harmful.
So, youre still going to die one day. But as to when, that answer probably doesnt reside in what you eat (or in young blood) nearly as much as it does in what your DNA looks like.
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Scientists Discover a Key to a Longer Life in Male DNA – New York Times
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New York Times | Scientists Discover a Key to a Longer Life in Male DNA New York Times But large-scale surveys of people's DNA have revealed few genes with a clear influence on longevity. It's been a real disappointment, said Nir Barzilai, a geneticist at Albert Einstein College of Medicine. Researchers are having better luck following ... |
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How population health will benefit from the journey to precision medicine – MedCity News
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Population health and precision medicine seem like such polar opposites standing 180 degrees apart. But the path to fully realizing the benefits of precision medicine stands to reap rewards for population health along the way. That was the takeaway from an interview with India Hook-Barnard, the director of research strategy and associate director of Precision Medicine at the University of California San Francisco School of Medicine. She talked about the balance between the two areas of healthcare in an interview in Boston after she spoke at the HIMSS Precision Medicine Summit this week.
Hook-Barnard called attention to a list of projects related to precision medicine. They included the Cell Cancer Map Initiative to discover molecular networks of cancer, the University of California Data Warehouse to connect 15 million electronic health records across the University of California health system, a Biobank that seeks to simplify the informed consent process and the Scalable Precision Open Knowledge Engine.
All of these projects are helping to advance precision medicine in different ways. They will enable us to more quickly make discoveries, provide better care, but also make better decisions in public health.
She called attention to some of the work of her colleagues. Atul Butte is the first director for the Institute of Computational Health Sciences. Among his many roles, he is one of the leaders of the University of California Data Warehouse. Among their tasks are to address privacy and security issues for making data from those records accessible across health systems plugged into the University of California network.
Theyre looking at being able to repurpose drugs, what will really provide better outcomes. It will be really huge being able to connect that kind of data and use it in a healthcare space and research space.
The San Francisco Cancer Initiative, is about sharing information for what works and what doesnt work for five types of cancer with the highest cost burden: prostate, breast, liver, colorectal and tobacco-related cancers. Each will be assigned a taskforce, Hook-Barnard said. The public-private partnership launched last year with a $3 million investment from a donor to the UCSF Helen Diller Family Comprehensive Cancer Center. The initiative is led by Dr. Robert Hiatt, the chair of the Department of Epidemiology and Biostatistics at UCSF. He authored a report on health disparities for cancer treatment outcomes.
Hook-Barnard described what the program seeks to accomplish using tobacco-related cancer as an example, and highlighted some of the questions the initiative seeks to address in this area. Social determinants of health will also come into play.
We know the dangers of smoking and the impact of it, yet there are certain communitiesthat are still developing lung cancer at much higher rate than others. Why is that? Is the messaging on prevention not resonating? Are cessation efforts not tailored enough to be effective? Is access to early screening for detection in certain neighborhoods [the problem]? Being able to tailor those kinds of preventive messaging, early screenings, diagnostics and access, could improve earlier access to treatment.
The Molecular Oncology initiative led by Michael Korn of UCSF is yet another initiative. The website offers this description of the UCSF500 gene panel assay the laboratory conducts.
a cutting-edge sequencing test that, in contrast with commercial cancer gene panel tests, sequences tumor DNA and the patients germline (inherited) DNA. This unique component of the UCSF500 molecular diagnostic test enables identification of genetic changes (mutations) in the DNA of a patients cancer, which helps oncologists improve treatment by identifying targeted therapies, or appropriate clinical trials, or in some cases clarify the exact type of cancer a patient has.
Although it is about using genomics in the clinic to get a more precise diagnosis, the goal of the initiative is to solve some of the wider questions that often go unanswered and to make sure that data isnt locked in a silo somewhere. What treatment(s) worked and why?
How do we capture that information to make sure that is shared and duplicated? We want to make sure those lessons, those findingsonce you have that piece of knowledge, how do you make sure it is shared with other medical centers? For precision medicine to work, it is about these different kinds of data and acquiring knowledge we need to enable data sharing.
Photo: Getty Images
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