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Category Archives: Transhuman News

Thousands of genes influence most diseases – Stanford Medical Center Report

Posted: June 21, 2017 at 3:45 am

A core assumption in the study of disease-causing genes has been that they are clustered in molecular pathways directly connected to the disease. But work by a group of researchers at the Stanford University School of Medicine suggests otherwise.

The gene activity of cells is so broadly networked that virtually any gene can influence disease, the researchers found. As a result, most of the heritability of diseases is due not to a handful of core genes, but to tiny contributions from vast numbers of peripheral genes that function outside disease pathways.

Any given trait, it seems, is not controlled by a small set of genes. Instead, nearly every gene in the genome influences everything about us. The effects may be tiny, but they add up.

The work is described in a paper published June 15 in Cell. Jonathan Pritchard, PhD, professor of genetics and of biology, is the senior author. Graduate student Evan Boyle and postdoctoral scholar Yang Li, PhD, share lead authorship.

The researchers call their provocative new understanding of disease genes an omnigenic model to indicate that almost any gene can influence diseases and other complex traits. In any cell, there might be 50 to 100 core genes with direct effects on a given trait, as well as easily another 10,000 peripheral genes that are expressed in the same cell with indirect effects on that trait, said Pritchard, who is also a Howard Hughes Medical Institute investigator.

Each of the peripheral genes has a small effect on the trait. But because those thousands of genes outnumber the core genes by orders of magnitude, most of the genetic variation related to diseases and other traits comes from the thousands of peripheral genes. So, ironically, the genes whose impact on disease is most indirect and small end up being responsible for most of the inheritance patterns of the disease.

This is a compellingpaper that presents a plausible and fascinatingmodel to explain a number of confusing observations from genomewide studies of disease, said Joe Pickrell, PhD, an investigator at the New York Genome Center, who was not involved in the work.

Until recently, said Pritchard, he thought of genetically complex traits as conforming to a polygenic model, in which each gene has a direct effect on a trait, whether that trait is something like height or a disease, such as autism.

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GE and the Mayo Clinic back software to bring cancer-fighting gene therapies to market – TechCrunch

Posted: at 3:45 am

Behind the incredible process of developing targeted gene therapies to fight diseases like cancer lies an incredibly mundane problem that prevents these treatments from getting to patients paperwork and procedures.

While $5.7 billion was invested in companies developing cellular and genetic therapies, and with 800 clinical trials initiated worldwide and the first two CAR-T cell therapies expected to launch into market later this year, businesses still saythe ability to get these treatments to patients is limited by paperwork, supply chain management, and last mile delivery.

So GE (through its GE Ventures arm), the Mayo Clinic (through Mayo Clinic Ventures) and the venture investment firm DFJ have invested $13.75 million to back Vineti a software platform the companies are billing as a solution to gene therapys supply chain problem.

Its only the sixth company to have actually been built by GEs internal business team and spun out by the conglomerates venture arm.

According to company co-founder and former GE Ventures managing director Amy DuRoss, the process for developing and managing gene therapies is critical to the success of the treatment.

Amy DuRoss, chief executive at Vineti

To that end, Vinetis software tracks logistics, manufacturing and clinical data to improve treatments and drive down the cost of these therapies (which are mainly only accessible to those people with the very best health plans).

The startups technology was actually born out of necessity (always the mother of invention) and came from conversations that GE was having with a large, undisclosed customer.

A pharma company that is a regular client of GE Healthcare said we are solving late stage cancer and we want to take this commercial but we have not got the technology that can ensure that we can scale out these technologies in the commercial phase, DuRoss told me.

GEs healthcare business then took the problem to the companys venture investment and new business arm and began the development process of building a business.

In addition to DuRoss, who has been a luminary in the life sciences field since she helped with the push to get stem cell research approved in California; Vineti has a murderers row of leading healthcare talent.

Chief strategy officer Heidi Hagen, was the former SVP of Operations for cell immunotherapy pioneer Dendreon; chief technology officer Razmik Abnous was the chief technology officer at the healthcare data management juggernaut Documentum; and Malek Faham, the companys chief science officer, literally worked on some of the foundational science for gene therapies.

While the companys technology could have applications for a number of different treatments, and be used for several kinds of therapies, the focus, for now, is on cancer.

Cancer is a bullseye, says DuRoss. It is arguably the biggest cause of human suffering [and] there are treatments already in phase three, that if brought to market effectively could mark a turning point in medicines battle against the deadly disease, she said.

We see an opportunity as data accrues to the system over time for a use case in predicting therapy based on outcome data but were not making these claims today, said DuRoss.

Mayo Ventures had been working with GE for two years from the initial concept to the close of this new round of financing for Vineti. Its one of only 15 companies that the Clinic has backed since the formation of Mayo Clinic Ventures, and according to Andy Danielsen, the vice chair of Mayo Clinic Ventures.

One thing with Vineti that we liked is that we have a commitment to cell and gene therapies at Mayo, said Danielsen, so the interests were aligned. Vineti will make the gene and cell therapy production process more efficient and as a result, less costly. Its all part of the equation of making these therapies more affordable and opening them up to a greater number of people.

Therapy supply chain

External ordering pages

Product tracking

Therapy scheduling

Identity verification

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GE and the Mayo Clinic back software to bring cancer-fighting gene therapies to market - TechCrunch

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Will patients’ lifestyles become more important to precision medicine than gene sequencing? – Genetic Literacy Project

Posted: at 3:45 am

While much of the excitement surrounding precision medicine focuses on using genomics to tailor personalized treatment plans, speakers at the Precision Medicine Summit said theres more to it.

We cannot achieve precision medicine without having everyone be a participant and benefit and understand, said India Barnard-Hook, director of strategy and associate director of precision medicine at University of California, San Francisco. Precision medicine is about much more than genomics.

Social determinants of health, for instance, typically occur outside the healthcare system and have a significant impact on both health and individual outcomes.

You have to know a lot more than the clinical phenotype, said Linda Chin, chief innovation officer for health affairs at The University of Texas Health System.If you understand all the other factors that contribute to diseases, those can alter the course of the disease and ultimately prevent it.

Penn Medicine associate vice president of health technology and academic computing Brian Wells even made the bold prediction that genetic sequencing may become less relevant as cancer treatments become increasingly sophisticated.

If we discover one immunotherapy that applies to all cancers, we really dont need to sequence your genome anymore, Wells said. Were at a tipping point and sequencing could become less important.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:With precision medicine, social determinants could be more insightful than genetics

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Physician using pharmacogenetics to determine best medications for individual patients – The Times and Democrat

Posted: at 3:45 am

A local family physician is taking much of the guesswork out of patient treatment with the help of drug-gene testing that determines how a persons genes affect their bodys response to medications.

The testing is also known as pharmacogenetics, a combination of the words pharmacology (the study of the uses and effects of medications) and genomics (the study of genes and their functions).

Dr. Monnie Singleton of Singleton Health Center in Orangeburg has been using pharmacogenetics testing for nearly a year to determine safe and effective medications and doses that will be tailored to a persons genetic makeup.

Pharmacogenetics testing is a revolutionary means of checking to see how patients are metabolizing the medications that they are taking. So were looking specifically at how a medication is metabolized by an individual, Singleton said.

He said drugs dont work the same for everyone and while it can be difficult to predict who will benefit from a medication, who will not respond at all and who will experience adverse drug reactions, the testing helps him eliminate the trial-and-error associated with prescribing medications.

This technology eliminates the need for us to just keep guessing at what might be the right medicine in an individual patient. I think as we move forward, were going to be looking specifically to see if the genetics in patients DNA makeup will allow proper metabolism of that drug, he said.

Singleton added, If the drugs arent metabolized normally, what we see in many people is that either not enough or too much enzyme is produced. If not enough enzyme is produced to metabolize the amount of medication the patient is taking, the patients blood levels of that drug will increase to the point of becoming toxic and them getting side effects and other adverse drug reactions.

If a person is manufacturing or making too much of the enzyme, then the medicine doesnt stay in their system long enough to work and it is being metabolized too rapidly.

Enzyme is a substance produced by a living organism that acts as a catalyst to bring about a specific biochemical reaction.

A small blood or saliva sample can help determine whether a medication may be an effective treatment for patients.

Singleton said a sponge is used to swab a patients mouth. The specimen is then shipped off for testing to Lawrenceville, Georgia-based, Alpha Genomix Laboratories, a molecular diagnostics laboratory dedicated to providing personalized patient care. Lab pesonnel look for changes to one or more genes that can affect a patients response to certain medications.

Singleton said a printout of an individual patients lab results are then sent back to his office.

We are testing for 26 different enzymes, or metabolic pathways, with this technology, he said.

Itll give a printout of several different classes of drugs. Whether that patient is taking drugs in that other class or not, it will still give a report as to whether a patient would metabolize it normally or not. So if a different medication needed to be prescribed for a different condition in the future, we could look at that list and see exactly what would be the best medication to start with, Singleton said.

The physician said 60 percent of his patients are on Medicare or Medicaid, both of which pay 100 percent of the testing cost.

The private insurances are beginning to pay for it, but they are not paying for it 100 percent, Singleton said.

What I have seen and have better come to understand is that 40 percent of the time, the antidepressants that are used with that trial-and-error method are the wrong medication. Using this guided therapy, or looking at the results of pharmacogenetics testing, allows me to select an antidepressant that the patient metabolizes normally," he said.

I select that medication to begin with and as a result, people get better quicker," Singleton said. "Ive certainly seen that in the area of depression. I have also seen it in the area of arthritis, gastroesophageal reflux disease and even when prescribing the statins for elevated cholesterol."

Patients who have had adverse drug reactions in the past and those who are taking five or more medications are among those who are recommended for pharmacogenetics testing, he said, noting that family members of patients who may not have had a good response to a medication may also be provided recommendations to see if they may benefit from testing.

Singleton said the testing is worthwhile and needed because it costs the federal government in excess of $3.5 billion a year to treat adverse reactions to drugs.

Forty percent of these adverse reactions are estimated to be preventable," he said.

I would say the overwhelming majority of the patients that we have talked to about the technology have elected to have the test done," Singleton noted. "On average, were having to make some change in a medication that the patient has been taking 30 percent of the time."

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Study: Meditation, Yoga and Related Practices Can ‘Reverse’ DNA Reactions – Sci-News.com

Posted: at 3:45 am

According to a study published in the journal Frontiers in Immunology, mind-body interventions such as mindfulness, yoga, Tai Chi, Qigong, relaxation response, and breath regulation dont simply relax us, they can reverse the molecular reactions in our DNA which cause ill-health and depression.

Ivana Buric et al analyze how the behavior of our genes is affected by different MBIs including mindfulness and yoga. Image credit: Nato Pereira.

When a person is exposed to a stressful event, the sympathetic nervous system the system responsible for the fight-or-flight response is triggered, in turn increasing production of a molecule called nuclear factor kappa B (NF-kB) which regulates how our genes are expressed.

NF-kB translates stress by activating genes to produce proteins called cytokines that cause inflammation at cellular level a reaction that is useful as a short-lived fight-or-flight reaction, but if persistent leads to a higher risk of cancer, accelerated aging and psychiatric disorders like depression.

However, people who practice mind-body interventions (MBIs) exhibit the opposite effect namely a decrease in production of NF-kB and cytokines, leading to a reversal of the pro-inflammatory gene expression pattern and a reduction in the risk of inflammation-related diseases and conditions, according to the study.

The inflammatory effect of the fight-or-flight response which also serves to temporarily bolster the immune system would have played an important role in mankinds hunter-gatherer prehistory, when there was a higher risk of infection from wounds, the authors said.

In todays society, however, where stress is increasingly psychological and often longer-term, pro-inflammatory gene expression can be persistent and therefore more likely to cause psychiatric and medical problems.

Millions of people around the world already enjoy the health benefits of mind-body interventions like yoga or meditation, but what they perhaps dont realize is that these benefits begin at a molecular level and can change the way our genetic code goes about its business, said lead author Ivana Buric, a PhD student at Coventry University, UK.

These activities are leaving what we call a molecular signature in our cells, which reverses the effect that stress or anxiety would have on the body by changing how our genes are expressed.

Put simply, MBIs cause the brain to steer our DNA processes along a path which improves our wellbeing.

More needs to be done to understand these effects in greater depth, for example how they compare with other healthy interventions like exercise or nutrition.

But this is an important foundation to build on to help future researchers explore the benefits of increasingly popular mind-body activities, Buric said.

_____

Ivana Buric et al. What Is the Molecular Signature of Mind-Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices. Front. Immunol, published online June 16, 2017; doi: 10.3389/fimmu.2017.00670

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Politically Incorrect It May Be, But There Is An Underlying Truth To Yogi Adityanath’s Views On Taj Mahal – Swarajya

Posted: at 3:44 am

Uttar Pradesh Chief Minister Yogi Adityanath, who does not believe in too much political correctness when speaking his mind, got himself into another controversy when he suggested that the Taj Mahal and other such monuments did not reflect Indian culture. Foreign dignitaries, he said, were now being given copies of the Gita and the Ramayana where earlier they were being given replicas of the Taj. (See an actual excerpt of his speech here)

Clearly, there was no need for Adityanath to rubbish the great monuments left behind by our Mughal rulers. The monuments, including the Taj, the Red Fort, the Qutb Minar and the ones at Fatehpur Sikri, are part of our history and heritage.

However, there is equally no need to hyperventilate on Adityanaths choice of words, for there is an intrinsic truth to what he was trying to convey. The true spirit of India is not defined by the monuments to human vanity that were left behind by past rulers, but the civilisational ethos, culture and spiritual pursuits of its people.

The spirit of India is represented by no monument, but by the millions of Indians who turn up at the Kumbh, unheralded and unbid, to bond with their sense of the sacred at places like Prayag, Ujjain and Nashik. Sure, there are many temples in these places to see, but the pilgrimage itself is not about clicking a selfie in front of a beautiful monument. Islam does not believe in god being represented in any form, but its adherents today (and Indias unholy Left) do not see this formless devotion to god in the millions who turn up at the Kumbh and Ardh Kumbh. They come, they do their thing, and they melt away without a fuss.

The spirit of India is defined by the millions who use yoga not as a health enhancing bit of muscle-stretching exercise, but as a way to balance mind and body in a perpetual search for higher reality. But today this is being rubbished as unIslamic and subverted into forms defined by organised religion, including the creation of so-called Christian yoga or Holy yoga. What is Christian about yoga? Perhaps the only way in which it is Christian is the blatant appropriation of Indias cultural and spiritual wealth by a civilisation ethos that does not respect our traditions. This hypocrisy is emphasised by western civilisations normally high emphasis on the protection of its own intellectual property rights. But other peoples cultural properties can be looted and stolen.

The idea of India is not defined by a westernised elite sitting at the India International Centre (IIC) in Delhi or the Habitat Centre, but by a common Indic sense of living in a sacred geography, and the footfalls of its pilgrims, as scholar of religious studies Diana Eck put it. It needs a westerner to see us and tell us what we are, but no Indian liberal is able to see it.

Syncretic India, to which the religions and ideas that came from outside also contributed, is not defined by the monuments the latter left behind, but by their contributions to the spirit and culture of this country. The real Mughal contribution to India is not the Taj Mahal beautiful as it is but how Mughal rule helped infuse new life into Indian music, which is now celebrated as Hindustani music and enthrals millions all over the sub-continent.

When it comes to grand monuments, we were never lacking in them as the fantastic temples at Thanjavur, Tirupati, Srirangam, Guruvayoor and Sabarimala attest, as also do the gigantic Gomateshwara in Sravanabelagola, or the cave art of Ajanta, Ellora and Elephanta, or the Golden Temple in Amritsar. But it is the Indian spirit that dominates, not the monument or the moorti created with the effort.

Contrast this spirit of India with the iconoclasm of Islam, where grand monuments were often built by demolishing those that already existed in Varanasi, Ayodhya and Mathura. The distinguishing features of the temples or Buddhist seminaries demolished were not their architectural qualities alone, but the devotion that made them possible.

In fact, some of Indias holiest temples are not distinguished by their imposing nature, but by our sense of the sacred and the spiritual in them. The Kashi Vishwanath temple is nobodys idea of grandeur, but still it attracts millions every year.

Nothing illustrates this spirit better than the Somnath temple, which was repeatedly looted, plundered and demolished by Islamic invaders like Ghori and Ghazni. Left historians like Romila Thapar see this as evidence that the temple destructions were not traumatic to those living at the time they were destroyed, since they did not explicitly say so in contemporary literature, but she misses the simple point: to the Indic mind, where glory is transient and hubris anathema, it is the effort that matters, not the outcome. Doesnt the Gita itself say so in its reference to nishkama karma?

Yogi Adityanaths reference to the Ramayana and the Gita are important for the simple reason that todays card-carrying secularists think it is something that belongs only to Hindus, and the mere telecast of a Ramayana or a Mahabharata on Doordarshan was tantamount to communalism. To a Sheldon Pollock, the Ramayana is a mere tool to get citizens to respect the kings authority unquestioningly, when the Ramayana itself disproves this point, by being rendered in more than 300 renditions hardly a tribute to a peoples blind adherence to monoculture and obedience. Nobody in India collected 300 important priests and pandits to decide that only one version of the Ramayana is valid, as Constantine did with the Bible in the Council of Nicea. And while every westerner accepts Homers Illiad and the Odyssey as part of her cultural heritage, only in India are non-Hindus told to treat the Ramayana, the Mahabharata, the Vedas, the Upanishads, the Gita or even Sanskrit as a limited heritage.

The UP Chief Ministers comments on the Taj Mahal should be seen in this context, and not in terms of the words he spoke. India does not benefit by pretending all its culture and achievement are encapsulated in the Taj Mahal or the Red Fort.

The reason why the Taj and the Red Fort occupy such important places in tourist literature is an accident of geography they are in and around Delhi, where many of Indias Islamic kings and the latter-day colonials chose to make their political centre.

A 5,000-year-old civilisation cannot be reduced to a few monuments build in the last millennium, nor should it seek to bury the past in the ruins of Hampi. If you want to extol the creativity of the Taj, dont forget to also extol the even greater virtues of the Vijayanagar empire that achieved another peak in Indian architectural and devotional splendour, but fell victim to mindless bigoted iconoclasm.

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Politically Incorrect It May Be, But There Is An Underlying Truth To Yogi Adityanath's Views On Taj Mahal - Swarajya

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Appreciation becomes appropriation: Is deeming yoga politically … – National Post

Posted: at 3:44 am


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Appreciation becomes appropriation: Is deeming yoga politically ...
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Yoga joins a long list of art, fashion, music, sports and activities chastised as insensitive or racist acts by a Western or white majority cultural appropriation from ...

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China – Wikitravel

Posted: at 3:44 am

119 for fire 120 for medical

China (; Zhnggu), officially known as the People's Republic of China ( Zhnghu Rnmn Gnghgu) is a huge country in Eastern Asia (about the same size as the United States of America) with the world's largest population.

With coasts on the East China Sea, Korea Bay, Yellow Sea, and South China Sea, in total it borders 14 nations. It borders Afghanistan, Pakistan (through the disputed territory of Kashmir), India, Nepal, Bhutan, Myanmar, Laos and Vietnam to the south; Tajikistan, Kazakhstan and Kyrgyzstan to the west; Russia and Mongolia to the north and North Korea to the east. This number of neighbouring states is equalled only by China's vast neighbour to the north, Russia.

This article only covers mainland China. For Hong Kong, Macau and Taiwan, please see separate articles.

The roughly 5000-year old Chinese civilization has endured through millennia of tumultuous upheaval and revolutions, periods of golden ages and anarchy alike. Through the recent economic boom initiated by the reforms of Deng Xiaoping, China is once again one of the leading nations in the world, buoyed by its large, industrious population and abundant natural resources. The depth and complexity of the Chinese civilization, with its rich heritage, has fascinated Westerners such as Marco Polo and Gottfried Leibniz through the Great Silk Road and more ways of culture exchange in centuries past, and will continue to excite - and bewilder - the traveler today.

The recorded history of Chinese civilization can be traced to the Yellow River valley, said to be the 'cradle of Chinese civilization'. The Xia Dynasty was the first dynasty to be described in ancient historical chronicles, though to date, no concrete proof of its existence has been found. Nevertheless, archaeological evidence has shown that at the very least, an early bronze age Chinese civilization had developed by the period described.

The Shang Dynasty, China's first historically confirmed dynasty, and the Zhou Dynasty ruled across the Yellow River basin. The Zhou adopted a decentralized system of government, in which the feudal lords ruled over their respective territories with a high degree of autonomy, even maintaining their own armies, while at the same time paying tribute to the king and recognizing him as the symbolic ruler of China. It was also the longest ruling dynasty in Chinese history, lasting about 800 years. Despite this longevity, during the second half of the Zhou period, China descended into centuries of political turmoil, with the feudal lords of numerous small fiefdoms vying for power during the Spring and Autumn Period, and later stabilized into seven large states in the Warring States period. This tumultuous period gave birth to China's greatest thinkers including Confucius, Mencius and Laozi, who made substantial contributions to Chinese thought and culture.

China was eventually unified in 221 BC by Qin Shi Huang, the 'First Emperor', and the Qin Dynasty instituted a centralized system of government for all of China, and standardized weights and measures, Chinese characters and currency in order to create unity. Until today, the ideal of a unified and strong centralized system is still strong in Chinese thought. However, due to despotic and harsh rule, the Qin dynasty lasted for only 15 years as the Han Dynasty took over in 206BC after a period of revolt. With the invention of paper and extensive trade with the West along the Silk Road, along with relatively benevolent imperial rule, the Han was the first golden age of Chinese civilization. Ethnic Chinese consider themselves to be part of the 'Han' race till this day.

The collapse of the Han Dynasty in 220 CE led to a period of political turmoil and war known as the Three Kingdoms Period, which saw China split into the three separate states of Wei, Shu and Wu. Despite lasting for only about 60 years, it is a highly romanticised period of Chinese history. China was then briefly reunified under the Jin Dynasty, before descending into a period of division and anarchy once again. The era of division culminated with the Sui which reunified China in 581. The Sui were famous for major public works projects, such as the engineering feat of the Grand Canal, which linked Beijing in the north to Hangzhou in the south. Certain sections of the canal are still navigable today.

Bankrupted by war and excess government spending, the Sui were supplanted by the Tang Dynasty, ushering in the second golden age of Chinese civilization, marked by a flowering of Chinese poetry, Buddhism and statecraft, and also saw the development of the Imperial Examination system which attempted to select court officials by ability rather than family background. Chinatowns overseas are often known as "Street of the Tang People" ( Tngrn ji) in Chinese. The collapse of the Tang Dynasty then saw China divided once again, until it was reunified by the Song Dynasty, this collapse was preceded by the secession and independence of Vietnam in 938 CE. The Song ruled over most of China for over 150 years before being driven south of the Huai river by the Jurchens, were they continued to rule as the Southern Song, and although militarily weak, attained a level of commercial and economic development unmatched until the West's Industrial Revolution. The Yuan (Mongol) dynasty first defeated the Jurchens, then proceeded to conquer the Song in 1279, and ruled their vast Eurasian empire from modern-day Beijing.

After defeating the Mongols, the Ming dynasty (1368-1644) re-instituted rule by ethnic Han. The Ming period was noted for trade and exploration, with Zheng He's numerous voyages to Southeast Asia, India and the Arab world. Initial contact with European traders meant China gradually reaped the fruits of the Colombian exchange, with silver pouring in by the galleon through trade with the Portuguese and Spanish. Famous buildings in Beijing, such as the Forbidden City and the Temple of Heaven, were built in this period. The last dynasty of the Qing (Manchu) dynasty (1644-1911), saw the Chinese empire grow to its current size, incorporating the western regions of Xinjiang and Tibet. The Qing dynasty fell into decay in its final years to become the 'sick man of Asia', where it was nibbled apart by Western powers. The Westerners established their own treaty ports in Guangzhou, Shanghai and Tianjin. China lost several territories to foreign powers; Hong Kong and Weihai were ceded to Britain, Taiwan and Liaodong were to Japan, parts of the North East including Dalian and parts of Outer Manchuria to Russia, while Qingdao was ceded to Germany. Shanghai was divided among China and eight different countries. In addition, China lost control of its tributaties, with Korea and the Ryukyu Islands ceded to Japan.

The two thousand-year old imperial system collapsed in 1911, where Sun Yat-Sen (, Sn Zhngshn) founded the Republic of China ( Zhnghu Mngu). Central rule collapsed in 1916 after Yuan Shih-kai, the second president of the Republic and self-declared emperor, passed away; China descended into anarchy, with various self-serving warlords ruling over different regions of China. In 1919, student protests in Beijing gave birth to the "May Fourth Movement" ( W S Yndng), which espoused various reforms to Chinese society, such as the use of the vernacular in writing, as well as the development of science and democracy. The intellectual ferment of the May Fourth Movement gave birth to the reorganized Kuomintang (KMT) in 1919 and the Chinese Communist Party (CCP) in the French Concession in Shanghai, 1921.

After uniting much of eastern China under KMT rule in 1928, the CCP and the KMT turned on each other, with the CCP fleeing to Yan'an in Shaanxi in the epic Long March. During the period from 1922 to 1937, The eastern provinces of China grew economically under the leadership of Chiang Kai-shek and his KMT government, with marked economic expansion, industrialization and urbanization. Shanghai became a truly cosmopolitan city, as one of the world's busiest ports, and the most prosperous city in East Asia, home to millions of Chinese and 60,000 foreigners from all corners of the globe. However, underlying problems throughout the vast country side, particularly the more inland parts of the country, such as civil unrest, famines and warlord conflict, still remained.

Japan established a puppet state under the name Manchukuo in Manchuria in 1931, and launched a full-scale invasion of China's heartland in 1937. The Japanese initiated a brutal system of rule in Eastern China, culminating in the Nanjing Massacre of 1937. After fleeing west to Chongqing, the KMT realized the urgency of the situation signed a tenuous agreement with the CCP to form a second united front against the Japanese. With the defeat of Japan in 1945, the KMT and CCP armies maneuvered for positions in north China, setting the stage for the civil war in the years to come. The civil war lasted from 1946 to 1949 and ended with the Kuomintang defeated and sent packing to Taiwan where they hoped to re-establish themselves and recapture the mainland some day.

Mao Zedong officially declared the establishment of the People's Republic of China on 1 Oct 1949. The new Communist government implemented strong measures to restore law and order and revive industrial, agricultural and commercial institutions reeling from more than a decade of war. By 1955, China's economy had returned to pre-war levels of output as factories, farms, labor unions, civil society and governance were brought under Party control. After an initial period closely hewing to the Soviet model of heavy industrialization and comprehensive central economic planning, China began to experiment with adapting Marxism to a largely agrarian society.

Massive social experiments such as the Hundred Flowers Campaign ( bihu yndng), the Great Leap Forward ( dyujn), intended to collectivize and industrialize China quickly, and the Cultural Revolution ( wchn jij wnhu d gmng), aimed at changing everything by discipline, destruction of the "Four Olds," and total dedication to Mao Zedong Thought, rocked China from 1957 to 1976. The Great Leap Forward and Cultural Revolution are generally considered disastrous failures in China. During the Cultural Revolution in particular, China's cultural heritage, including monuments, temples, historical artifacts, and works of literature sustained catastrophic damage at the hands of Red Guard factions. It was only due to the intervention of Zhou Enlai and the PLA that major sites, such as the Potala Palace, the Mogao Caves, and the Forbidden City escaped destruction during the Cultural Revolution.

Mao Zedong died in 1976, and in 1978, Deng Xiaoping became China's paramount leader. Deng and his lieutenants gradually introduced market-oriented reforms and decentralized economic decision making. Economic output quadrupled by 2000 and continues to grow by 8-10% per year, but huge problems remain bouts of serious inflation, regional income inequality, human rights abuses, ethnic unrest, massive pollution, rural poverty and corruption. While the larger cities near the coast like Beijing, Shanghai and Guangzhou have grown to become rich and modern, many of the more inland and rural parts of the country remain poor and underdeveloped. The former General Secretary of the Communist Party, Hu Jintao, has proclaimed a policy for a "Harmonious Society" ( hxi shhu) which promises to restore balanced economic growth and channel investment and prosperity into China's central and western provinces, which have been largely left behind in the post-1978 economic boom. The current General Secretary of the Communist Party, Xi Jinping and Premier Li Keqiang, have pursued an ambitious policy of social reform, particularly income redistribution, poverty relief, and environmental improvements. Furthermore, a highly ambitious crackdown on corruption started by the previous administration has only been expanded. Growth in China has finally slowed down in recent years and seems to be leveling off.

China is a single-party socialist state ruled by the Communist Party of China. China has actually only experienced one open nation-wide election, in 1912. The government consists of an executive branch known as the State Council ( Gu W Yun), as well as a unicameral legislature known as the National People's Congress ( Qungu Rnmn Dibio Dhu). The nominal Head of State is the President ( zhx, lit chairman) which is a largely ceremonial office with limited powers and the Head of Government is the Premier ( zngl). In practice, while neither one holds absolute power, the General Secretary of the Communist Party of China holds the most power, while the Premier of the State Council is the second most powerful person in the country.

The country is administratively divided into 22 provinces, 5 autonomous regions and 4 directly-controlled municipalities. Each of the provincial governments is given power over the internal, often economic, affairs of their provinces. Autonomous regions are given more freedom than regular provinces, one example of which is the right to declare additional official languages in the region besides Mandarin. In addition, there are the Special Administrative Regions (SAR) of Hong Kong and Macau. Both Hong Kong and Macau have separate legal systems and immigration departments from the mainland, and are given the freedom to enact laws separately from the mainland. Their political systems are more open and directly electoral in nature. Taiwan is also claimed by the PRC as a province, though no part of Taiwan is currently under the control of the PRC. Both governments support re-unification in principle and recently signed a trade pact to closer link their economies, essentially removing the danger of war.

China is a very diverse place with large variations in culture, language, customs and economic levels. The economic landscape is particularly diverse. The major cities such as Beijing, Guangzhou and Shanghai are modern and comparatively wealthy. However, about 50% of Chinese still live in rural areas even though only 10% of China's land is arable. Hundreds of millions of rural residents still farm with manual labour or draft animals. Some 200 to 300 million former peasants have migrated to townships and cities in search of work. Government estimates for 2005 reported that 90 million people lived on less than 924 a year and 26 million were under the official poverty line of 668 a year. Generally the southern and eastern coastal regions are more wealthy while inland areas, the far west and north, and the southwest are much much less developed.

The cultural landscape is unsurprisingly very diverse given the sheer size of the country. China has 56 officially recognized ethnic groups; the largest by far is the Han which comprise over 90% of the population. The other 55 groups enjoy affirmative action for university admission and exemption from the one-child policy. The Han, however, are far from homogeneous and speak a wide variety of mutually unintelligible local "dialects"; which most linguists actually classify as different languages using more or less the same set of Chinese characters. Many of the minority ethnic groups have their own languages as well. Contrary to popular belief, there is no single unified Han Chinese culture, and while they share certain common elements such as Confucian and Taoist beliefs, the regional variations in culture among the Han ethnic group are actually very diverse. Many customs and deities are specific to individual regions and even villages. Celebrations for the lunar new year and other national festivals vary drastically from region to region. Specific customs related to the celebration of important occasions such as weddings, funerals and births also vary widely. In general contemporary urban Chinese society is rather secular and traditional culture is more of an underlying current in every day life. Among ethnic minorities, the Zhuang, Manchu, Hui and Miao are the largest in size. Other notable ethnic minorities include: Koreans, Tibetans, Mongols, Uighurs, Kirghiz and even Russians. In fact, China is home to the largest Korean population outside Korea and is also home to more ethnic Mongols than the Republic of Mongolia itself. Many minorities have been assimilated to various degrees with the loss of language and customs or a fusing with Han traditions. An exception to this trend is the current situation of the Tibetans and Uighurs in China who remain fiercely defensive of their cultures.

Some behaviours that are quite normal in China may be somewhat jarring and vulgar for foreigners:

Some long-time foreign residents say such behaviours are getting worse; others say the opposite. The cause is usually attributed to the influx of millions of migrants from the countryside who are unfamiliar with big city life. Some department stores place attendants at the foot of each escalator to keep folks from stopping to have a look-see as soon as they get off - when the escalator behind them is fully packed.

On the whole, however, the Chinese love a good laugh and because there are so many ethnic groups and outsiders from other regions, they are used to different ways of doing things and are quite okay with that (in tier one and tier two cities at least). Indeed the Chinese often make conversation with strangers by discussing differences in accent or dialect. They are very used to sign language and quick to see a non-verbal joke or pun wherever they can spot one. Note that a laugh doesn't necessarily mean scorn, just amusement. The Chinese like a "collective good laugh" often at times or circumstances that westerners might consider rude. Finally, the Chinese love and adore children, allow them a great deal of freedom, and heap attention upon them. If you have children, bring them!

In general, 3, 6, 8, and 9 are lucky numbers for most of the Chinese. Three means high above shine the three stars while the three stars include gods of fortune, prosperity and longevity. Six represents smoothness or success. Many young people choose the dates with six as their wedding days, such as the 6th, 16th and 26th. Eight sounds so close to the word for wealth that many people believe eight is a number that is linked to prosperity. So it is no surprise that the opening ceremony for the Olympics started at 8:08:08 on 08/08/2008. Nine is also regarded as a lucky number with the meaning of everlasting.

Four is a taboo for most Chinese because the pronunciation in Mandarin is close to death. Some hotels will have their floor numbers go straight from three to five much like some American hotels have their floor numbers go from twelve to fourteen, skipping the "unlucky" number 13.

Given the country's size the climate is extremely diverse, from tropical regions in the south to subarctic in the north. Hainan Island is roughly at the same latitude as Jamaica, while Harbin, one of the largest cities in the north, is at roughly the latitude of Montreal and has the climate to match. North China has four distinct seasons with intensely hot summers and bitterly cold winters. Southern China tends to be milder and wetter. The further north and west you travel, the drier the climate. Once you leave eastern China and enter the majestic Tibetan highlands or the vast steppes and deserts of Gansu and Xinjiang, distances are vast and the land is very harsh.

Back in the days of the planned economy, the rules stated that buildings in areas north of the Yangtze River got heat in the winter, but anything south of it did not this meant unheated buildings in places like Shanghai and Nanjing, which routinely see temperatures below freezing in winter. The rule has long since been relaxed, but the effects are still visible. In general, Chinese use less heating, less building insulation, and wear more warm clothing than Westerners in comparable climates. In a schools or apartments and office buildings, even if the rooms are heated, the corridors are not. Double glazing is quite rare. Students wear winter jackets in class, along with their teachers and long underwear is very common. Air conditioning is increasingly common but is similarly not used in corridors and is often used with the windows and doors open.

There is a wide range of terrain to be found in China with many inland mountain ranges, high plateaus, and deserts in center and the far west. Plains, deltas, and hills dominate the east. The Pearl River Delta region around Guangzhou and Hong Kong and the Yangtze delta around Shanghai are major global economic powerhouses, as is the North China plain around Beijing and the Yellow River. On the border between Tibet, (the Tibet Autonomous Region) and the nation of Nepal lies Mount Everest, at 8,850 m, the highest point on earth. The Turpan depression, in northwest China's Xinjiang is the lowest point in the country, at 154 m below sea level. This is also the second lowest point on land in the world after the Dead Sea.

China is a huge country with endless and affordable travel opportunities. During holidays, however, hundreds of millions of migrant workers return home and millions of other Chinese travel within the country (but many in the service sector stay behind, enjoying extra pay). Travelers may want to seriously consider scheduling to avoid being on the road, on the rails, or in the air during the major holidays. At the very least, travel should be planned well well in advance. Every mode of transport is extremely crowded; tickets of any kind are hard to come by, and will cost you a lot more, so it may be necessary to book well in advance (especially for those travelling from remote western China to the east coast or in the opposite direction). Train and bus tickets are usually quite easy to buy in China, (during the non-holiday season), but difficulties arising from crowded conditions at these times cannot be overstated. Travellers who are stranded at these times, unable to buy tickets, can sometimes manage to get air tickets, which tend to sell out more slowly because of the higher but still affordable (by western standards) prices. For the most comfortable mode of transportation, air travel is the obvious choice. There is an emerging ultra-modern bullet train network which is also very nice, but you may still have to potentially deal with many insanely overcrowded, smoke-filled, cold, loud and disorganized train depots to get on-board. The spring festival (Chinese New Year) is the largest annual migration of people on earth.

Lunar New Year dates The year of the Horse started on 31 Jan 2014

China has five major annual holidays:

The Chinese New Year and National Day are not one-day holidays; nearly all workers get at least a week for Chinese New Year, some get two or three, and students get four to six weeks. For National Day, a week is typical.

The Chinese New Year is especially busy. Not only is it the longest holiday, it is also a traditional time to visit family. The entire country is pretty much shut down during the period. More or less all the migrant workers who have left their farms and villages for better pay in the cities go home. This is often the only chance they have. Everyone wants to go home, and China has a lot of "everyone"! Around the Chinese New Year, many stores and other businesses will close for several days, a week, or even longer, so unless you have close friends or relatives in China, it is not ideal to visit during this period.

Also, during early July university students (twenty-odd million of them!) go home and in late August they return to school, jamming transportation options especially between the east coast and the western regions of Sichuan, Gansu, Tibet, and Xinjiang.

A complete list of Chinese festivals would be very long since many areas or ethnic groups have their own local ones. See listings for individual towns for details. Here is a list of some of the nationally important festivals not mentioned above:

In addition to these, some Western festivals are noticeable, at least in major cities. Around Christmas, one hears carols mostly English, a few in Latin, plus Chinese versions of "Jingle Bells", "Amazing Grace", and for some reason "Oh Susana". Some stores are decorated and one sees many shop assistants in red and white elf hats. For Valentine's Day, many restaurants offer special meals. Chinese Christians celebrate services and masses at officially sanctioned Protestant and Catholic churches as well.

Non-guidebooks, either about China, or by Chinese writers.

Travel:

Literature:

History:

For a complete list of provinces and an explanation of China's political geography, see: List of Chinese provinces and regions.

We cover Hong Kong, Macau and Taiwan in separate articles. From the practical traveller's point of view, they are distinct as each issues its own visas, currency and so on.

Politically, Hong Kong and Macau are Special Administrative Regions, part of China but with capitalist economies and distinct political systems. The slogan is "One country, two systems".

Taiwan is a special case. At the end of the civil war in 1949, the Communists held most of China and the defeated Nationalists held only Taiwan and a few islands off the Fujian coast. That situation continues to this day; Taiwan has had a separate government for more than 60 years and as such, is governed "de-facto" independently. However, most world bodies do not recognize it as a sovereign state - amongst other factors, this may be attributed to the strong influence of the PRC government in this matter. Both governments in theory support eventual reunification of these "two Chinas", but there is also a significant pro-independence movement within Taiwan.

China has many large and famous cities. Below is a top ten list of some of those most important to travellers in mainland China. Other cities are listed under their specific regional section. See the Dynasties and capitals section for a detailed list of China's many previous capitals.

You can travel to many of these cities using the new fast trains. In particular, the Hangzhou - Shanghai - Suzhou - Nanjing line is a convenient way to see these historic areas.

Citizens of the following countries do not need a visa to travel to Mainland China;

For 15 days

For 30 days

For 90 days

Residents of Armenia, Azerbaijan, Bangladesh, Benin, Bosnia and Herzegovina, Bulgaria, Cuba, Georgia, Guyana, Laos, Macedonia, Moldova, Mongolia, North Korea, Pakistan, Serbia, Tajikistan, Turkey, Turkmenistan, and Vietnam must have their passported endorced as "For public affairs" by the Chinese government in order to enter visa free.

For citizens of Albania, Argentina, Australia, Austria, Belgium, Bosnia and Herzegovina, Brazil, Brunei, Bulgaria, Canada, Chile, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Japan, Latvia, Lithuania, Luxembourg, Macedonia, Malta, Mexico, Montenegro, Netherlands, New Zealand, Poland, Portugal, Qatar, Romania, Russia, Serbia, Singapore, Slovakia, Slovenia, South Korea, Spain, Sweden, Switzerland, Ukraine, United Arab Emirates, United Kingdom, and United States/American Samoa, you are allowed a 144-hour visa-free stopover in Shanghai/Hangzhou/Nanjing or a 72-hour visa-free stopover in Beijing, Changsha, Chengdu, Chongqing, Dalian, Guangzhou, Guilin, Harbin, Kunming, Qingdao, Shenyang, Tianjin, Wuhan, Xi'an or Xiamen provided you meet several conditions including:

More details can be found here: [5]. There is also a dedicated discussion and wiki-style summary on China's visa-free stopover policies in the FlyerTalk forum.

If you do not qualify for the 144 or 72 hour visa-free stopover (for example, if you are not flying into or out of one of the qualifying airports, or if you are not a citizen of one of the qualifying countries), you may be able to avail of the 24 hour visa-free stopover instead. This is available at all airports in China served by international flights (except for Fuzhou, Mudanjiang, Shenzhen and Yanji airports, and available at Urumqi airport only if you spend no more than 2 hours in Urumqi). The 24 hour period begins from your scheduled flight arrival time, until your scheduled flight departure time. For the 24 hour visa-free stopover, there are no territorial restrictions on your movement within mainland China (except Tibet) during your stopover, and you are not required to fly out of the same airport as the one you flew into. For example, if you arrive in Beijing at 06:00, you can travel to another city and fly out of another airport as long as your scheduled departure time is before 06:00 the following day.

Those visiting Hong Kong and Macau are able to visit the Pearl River Delta visa-free only under certain conditions.

Citizens of Azerbaijan, Belarus, Georgia, Moldova, Russia, and Turkmenistan can visit visa-free for 30 days, if traveling with a tour group that is accompanied by a representative of a tour operator registered in both countries.

The special economic zone province of Hainan allows visa-free access to Mainland China (Only Hainan though) for 15 days for nationals of the following countries; Australia, Austria, Canada, Denmark, France, Finland, Indonesia, Italy, Japan, Kazakhstan, Netherlands, New Zealand, Norway, Philippines, Singapore, Spain, Sweden, Switzerland, Thailand, Ukraine, United Kingdom, and United States. As long as they are visiting as part of a Chinese government controlled agency in Hainan with 5 people or more. Nationals of Germany, Russia, and South Korea can enter visa-free for 21 days with a tourist group of 2 people or more.

Citizens of Russia can visit the city of Suifenhe visa-free for up to 15 days. As long as you are accompanied by someone. Residents of the Amur oblast can visit the city of Heihe visa-free for 24 hours.

Residents of the East Kazakhstan Region in Kazakhstan can visit the city of Tacheng without a visa for 72 hours, which is about 3 days.

Most travellers will need a visa ( qinzhng) to visit mainland China. In most cases, this should be obtained from a Chinese embassy or consulate before departure. Visas for Hong Kong and Macau can be obtained through a Chinese embassy or consulate, but must be applied for separately from the mainland Chinese visa. However, citizens from most Western countries do not need visas to visit Hong Kong and Macau. Visitors from most western countries can stay in Hong Kong with free visa for 7 to 90 day. The time duration should depend on which country you are from. However, people from Afghanistan, Albania, Armenia, Bangladesh, Belarus, Burundi, Cambodia, Cameroon, Cuba and Ethiopia have to apply for a visa for Hong Kong before they travel to HK.

The most notable exception to this rule is transit through certain airports. Most airports allow a 12- to 24-hour stay without a visa so long as you do do not pass through immigration and customs (stay airside) and are en-route to a different country.

To visit mainland China, Hong Kong and Macau residents of Chinese nationality need to apply at the China Travel Service, the sole authorized issuing agent, to obtain a Home Return Permit (), a credit card sized ID allowing multiple entries and unlimited stay for 10 years with no restrictions including on employment. Taiwan residents may obtain an entry permit (valid for 3 months) at airports in Dalian, Fuhzou, Haikou, Qingdao, Sanya, Shanghai, Wuhan, Xiamen and China Travel Services in Hong Kong and Macau. Visitors must hold a Republic of China passport, Taiwanese Identity Card and Taiwan Compatriot Pass ( tibozhng). The Compatriot Pass may be obtained for single use at airports in Fuzhou, Haikou, Qingdao, Sanya, Wuhan and Xiamen. The entry permit fee is 100 plus 50 for issuing a single-use Taiwan Compatriot Pass. Travellers should check the most up-to-date information before traveling.

Visa overview

Getting a tourist visa is fairly easy for most passports as you don't need an invitation, which is required for business or working visas. The usual tourist single-entry visa is valid for a visit of 30 days and must be used within three months of the date of issue. A double-entry tourist visa must be used within six months of the date of issue. It is possible to secure a tourist visa for up to 90 days for citizens of some countries.

Tourist visa extensions can be applied for at the local Entry & Exit Bureaus against handing in the following documents: valid passport, visa extension application form including one 2-inch-sized picture, a copy of the Registration Form of Temporary Residence which you receive from the local police station at registration.

Some travellers will need a dual entry or multiple entry visa. For example, if you enter China on a single entry visa, then depart the mainland to Hong Kong or Macau, you need a new visa to re-enter the mainland. In Hong Kong, multiple entry visas are officially available only to HKID holders, but the authorities are willing to bend the rules somewhat and may approve three-month multiple entry visas for short-term Hong Kong qualified residents, including exchange students. It is recommended to apply directly with the Chinese government in this case, as some agents will be unwilling to submit such an application on your behalf. For holders of multiple entry visas to renew your visa you must leave China. The easist way was to go to Hong Kong, Seoul or some other country, cross the border and re-enter China. A new way is to go to Xiamen and cross to Jinmen island. Jinmen is held by Taiwan and like Hong Kong is offically considered leaving China. See details of below on boats to China.

There may be restrictions on visas for political reasons and these vary over time. For example:

A few years ago, the Z (working) visa was a long-term visa. Now a Z-visa only gets you into the country for 30 days; once you are there, the employer gets you a residence permit. This is effectively a multiple-entry visa; you can leave China and return using it. Some local visa offices will refuse to issue a residence permit if you entered China on a tourist (L) visa. In those cases, you have to enter on a Z-visa. These are only issued outside China, so obtaining one will likely require a departure from the mainland, for example to a neighbouring country. (Note that in Korea, tourists not holding an alien registration card must now travel to Busan, as the Chinese consulate in Seoul does not issue visas to non-residents in Korea.) They also usually require an invitation letter from the employer. In other cases it is possible to convert an L visa to a residence permit; it depends upon which office you are dealing with and perhaps on your employer's connections.

It is possible for most foreigners to get a visa in Ulaanbaatar, Mongolia. [1]. . (Dec 2010) Reservations for travel and hotel are acceptable. During busy periods, they may refuse entry after 11:00. There can be long queues so arrive early. Also be aware of major Chinese holidays, the Consular Section may be closed for several days.

Obtaining a Visa on Arrival is possible usually only for the Shenzhen or Zhuhai Special Economic Zones, and such visas are limited to those areas. When crossing from Hong Kong to Shenzhen at Lo Wu railway station, and notably not at Lok Ma Chau, a five day Shenzhen-only visa can be obtained during extended office hours on the spot for 160 (Oct 2007 price) for passport holders of many nationalities, for example Irish or New Zealand or Canadian. Americans are not eligible, while the fee for UK nationals is 450. The office accepts only Chinese yuan.

Any non-Chinese citizen must have a Tibet Travel Permit in order to enter Tibet. This permit is issued by the Tibet Tourism Bureau, and will be checked when going on board any buses, trains or airlines that bound for the TAR. However, the only way to obtain a Tibet Travel Permit is to arrange a tour operated by a Tibet travel agent which at least includes hotels and transportation. Foreigners are also not permitted to travel by public buses across Tibet and are only allowed to travel by private transportation as organised in the tour. Moreover, if entering Tibet from Nepal, one must also joined a group tour and be only allowed on a group visa. The Tibet Travel Permit has to be handed in to the tour guide upon arrival in the airport or train station, and to tour guide will keep the permit until the traveler left the TAR. The Tibet Travel Permit is also required by Taiwanese holding a Mainland Travel Permit for Taiwan Residents, but it is not required for Chinese citizens from Hong Kong or Macao holding a Mainland Travel Permit for Hong Kong and Macao Residents.

If staying in a hotel, guest house or hostel, the staff will request to see, and often scan, your passport, visa, and entry stamps at check-in.

If you are staying in a private residence, you are in theory required to register your abode with the local police within 24 (city) to 72 (countryside) hours of arrival, though in practice the law is rarely if ever enforced so long as you don't cause any trouble. The police will ask for (1) a copy of the photograph page of your passport, (2) a copy of your visa, (3) a copy of your immigration entry stamp, (4) a photograph, (5) a copy of the tenancy agreement or other document concerning the place you are staying in. That agreement might not be in your name but it will still be requested.

The main international gateways to mainland China are Beijing, Shanghai and Guangzhou. Almost every sizable city will have an international airport, but options are usually limited to flights from Hong Kong, neighbouring countries such as South Korea and Japan, and sometimes Southeast Asia.

Transiting Hong Kong and Macau

If arriving in Hong Kong or Macau there are ferries that can shuttle passengers straight to another destination such as Shekou or Bao'an Airport in Shenzhen, Macau Airport, Zhuhai and elsewhere without actually "entering" Hong Kong or Macau. A shuttle bus takes transit passengers to the ferry terminal so their official entry point, where they clear immigration, will be the ferry destination rather than the airport. Please note that the ferries do have different hours so landing late at night may make it necessary to enter either territory to catch another bus or ferry to one's ultimate destination. For example, it would be necessary to clear immigration if going from HK Int'l Airport to Macau via the Macau Ferry Terminal. The most recent information on the ferries to Hong Kong can be found at the Hong Kong International Airport website.[7]

While many major airlines now fly to Beijing, Shanghai, Guangzhou and Hong Kong, budget seats are often scarce. For good offers, book as early as possible. Tickets are particularly expensive or hard to come by at the beginning or end of summer when Chinese students abroad return home or fly back to their universities around the world. As with other travel in China, tickets can be difficult to get and will be expensive around Chinese New Year.

If you live in a city with a sizable overseas Chinese community, check for cheap flights with someone in that community or visit travel agencies operated by Chinese. Sometimes flights advertised only in Chinese newspapers or travel agencies cost significantly less than posted fares in English. However if you ask, you can get the same discount price.

See also: Discount airlines in Asia

Information: As a result of the H1N1-flu pandemic there are some kinds of health-checks currently in effect. These may be as simple as a customs person judging your appearance to IR-cameras checking for elevated body temperature. If there is a suspicion of flu, you will be quarantined for seven days.

Airlines and Routes

China's carriers are growing rapidly. Airbus estimates the size of Chinas passenger aircraft fleet will triple from 1,400 planes in 2009 to 4,200 planes in 2029.

Major domestic airlines include China Southern [8], China Eastern [9], Air China [10], and Hainan Airlines [11].

Fliers may prefer Asian airlines as they generally have more cabin staff and quality service. Hong Kong based Cathay Pacific [12] is an obvious possibility. Other candidates include Singapore Airlines [13], Japan Airlines [14], and Garuda Indonesia [15]. Korean Air [16] often has good prices on flights from various places in Asia such as Bangkok via Seoul to North America. Connecting flights may be cheaper than direct flights so keep this in mind. Korean Air also flies to more than a dozen Chinese cities.

Flights between Europe and China

China can be reached by train from many of its neighboring countries and even all the way from Europe.

China has land borders with 14 different countries; a number matched only by its northern neighbour, Russia. In addition, mainland China also has land borders with the Special Administrative Regions of Hong Kong and Macau, which are for all practical purposes treated as international borders. Most of the border crossings in western China are located in remote mountain passes, which while difficult to reach and traverse, often reward travellers willing to make the effort with breathtaking, scenic views.

Relations between the two nations are frosty, but the Nathu La Pass between Sikkim in India and Southern Tibet has recently reopened for cross-border trade. Currently the crossing is not open to tourists, and special permits are required to visit from either side.

Entering China from Myanmar is possible at the Ruili (China)-Lashio (Myanmar) border crossing, but permits need to be obtained from the Burmese authorities in advance. Generally, this would require you to join a guided tour.

For most travelers Hanoi is the origin for any overland journey to China. There are currently three international crossings:

You can catch a local bus from Hanoi's eastern bus station (Ben Xe Street, Gia Lam District, tel: 04/827-1529) to Lang Son, where you have to switch transport to minibus or motorbike to reach the border at Dong Dang. Alternatively there are many offers from open-tour providers; for those in a hurry, they might be a good option if they offer a direct hotel to border crossing transfer.

You can change money with freelance money changers, but check the rate carefully beforehand.

Border formalities take about 30 minutes. On the Chinese side, walk up past the "Friendship-gate" and catch a taxi (about 20, bargain hard) to Pingxiang, Guangxi. A seat in a minibus is 5. There is a Bank of China branch right across the street from the main bus station; the ATM accepts Maestro cards. You can travel by bus or train to Nanning.

You can take a train from Hanoi to Lao Cai for about 420,000 VND (as of 11/2011) for a soft sleeper. The trip takes about 8 hours. From there, it's a long walk (or a 5 minute ride) to the Lao Cai/Hekou border. Crossing the border is simple, fill out a customs card and wait in line. They will search your belongings (in particular your books/written material). Outside the Hekou border crossing is a variety of shops, and the bus terminal is about a 10 minute ride from the border. A ticket to Kunming from Hekou costs about 140; the ride is about 7 hours.

At Dongxing, you can take a bus to Nanning, a sleeper bus to Guangzhou (approximately 180), or a sleeper bus to Shenzhen (approximately 230, 12 hours) (March 2006).

From Luang Namtha you can get a bus leaving at around 08:00 going to Boten (Chinese border) and Mengla. You need to have a Chinese visa beforehand as there is no way to get one on arrival. The border is close (about 1 hr). Customs procedures will take another hour. The trip costs about 45k Kip.

Also, there is a direct Chinese sleeper bus connection from Luang Prabang to Kunming (about 32 hours). You can get on this bus at the border, when the minibus from Luang Namtha and the sleeper meet. Don't pay more than 200.

The Karakoram Highway from northern Pakistan into Western China is one of the most spectacular roads in the world. It's closed for tourists for a few months in winter. Crossing the border is relatively quick because of few overland travelers, and friendly relations between the two countries. A bus runs between Kashgar (China) and Sust (Pakistan) across the Kunerjab pass.

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China - Wikitravel

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Trump thanks Wall teens for ‘standing up’ to yearbook censorship – Asbury Park Press

Posted: at 3:44 am

Grant Berardo, a Wall High School junior, saw his image digitally altered with a plain black T-shirt in his yearbook. Mike Davis

High school yearbooks that featured digitally altered photographs of students supporting President Donald Trump will be reissued.

WALL The scandal over censorship of merchandise and quotes fromPresident Donald Trump in the Wall High School yearbook has reached the White House.

President Donald Trump and the director of his campaign thanked Wall High School students Montana and Wyatt Dobrovich-Fago, who reported a quote and logo featuring Trump's name removed from their class yearbooks.

The campaign also sent the teenagers a care package with shirts, hats, pins and patches.

"Thank you Wyatt and Montana two young Americans who arent afraid to stand up for what they believe in. Our movement to#MAGAis working because of great people like you!," Trump posted on Facebook.

THE LATEST:Wall HS to get new yearbooks after Trump shirt censorship

In a letter, campaign executive director Michael Glassner commended the students for "voicing their support" for Trump.

"It is more important than ever that we, as Americans, stand up for our beliefs and hopes for a better country," Glassner wrote. "And, as you know, it takes courage to do so. Butfreedom of expression should never go out of style let's not forget that!"

Wyatt, a junior at the school, wore a sweater vest featuring a Trump campaign logo on the school's picture day. But in the yearbook, his photo was cropped and the logo was barely visible an act Superintendent Cheryl Dyer has ruled was not intentional.

His sister, Montana, picked a quote from Trump to run alongside her photo alongside her role as freshman class president: "I like thinking big. If you are going to be thinking anything, you might as well think big," Trump's quote read.

Traditionally, all Wall class presidents can pick a quote. Montana's was submitted before the deadline passed and it's not yet clear whether it was purposely excluded, Dyer said last week.

Another student, junior Grant Berardo, saw his picture digitally altered before being published in the yearbook. Instead of the navy blue Trump campaign shirt he wore during the photo shoot, his yearbook photo featured a nondescript black T-shirt an "intentional" alteration, Dyer ruled.

FLASHBACK:Wall teen's Trump shirt censored in yearbook

The school board on Tuesday voted to formalize a suspension handed down to digital media teacher Susan Parsons, who Dyer suspended through the end of the school year last week.

The board is expected to continue discussing the case in executive session at future meetings, board attorney Michael Gross said.

Parsons, 62, was included on a list of re-hired teachers for the 2017-18 school year with a $92,000 salary, but that list was finalized before the yearbook censorship came to light.

She has not returned multiple calls to her home seeking comment.

Wall High School(Photo: File photo)

In response to the censorship scandal, Dyer last week ordered new yearbooks to be printed and reissued. Private, anonymous donors have contributed "at least $10,000" to cover the cost, Dyer said after Tuesday's board meeting.

But some members of the Wall school community have said it's not enough. Dyer has come under fire for handling the investigation despite last year posting aNew York Timesopinion article about "bullying in the age of Trump" on the school website.

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DISAFFECTED:Trump supporters at the Shore 'want their country back'

Wyatt Dobrovich-Fago also criticized Dyer for the "blatant anti-Trump stuff that's caused concern" for him.

"I feel like there's something else to the story. One person wouldn't just do this," Wyatt said. "There needs to be a proper investigation into this."

School Board President Allison Connolly disagreed, applauding Dyer and district administrators for "facing this situation head-on."

"We find the allegations of censorship disturbing and are taking the charges that studentshave had their rights compromised seriously," she said.

Mike Davis: 732-643-4223; mdavis@gannettnj.com

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Trump thanks Wall teens for 'standing up' to yearbook censorship - Asbury Park Press

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YouTube says LGBTQ+ video censorship won’t happen again – Engadget

Posted: at 3:44 am

YouTube apologized after getting hit by allegations that it censors LGBTQ+ content and fixed the bug that apparently caused the issue. Now, the website has apologized yet again and updated its policies in an effort to reaffirm its "commitment that YouTube is a place where all voices can be heard." YouTube chief Susan Wojcicki said she and her team talked to lesbian, gay, bi, trans and queer/questioning creators, employees and volunteers to get feedback on the platform's policies. As a result, the company has "broadened Restricted Mode guidelines to ensure that non-graphic, personal accounts of difficult events are available."

In a blog post, the CEO wrote:

"For example, personal accounts of individuals who suffered discrimination or were impacted by violence for being part of a protected group will now be included in Restricted Mode, provided they don't contain graphic language or content. Soon we'll have new content in Creator Academy to describe in detail how to make videos that will meet the criteria for Restricted Mode."

If you look at the website's guidelines, you'll now find this section:

"Some educational, straightforward content about sexual education, affection, or identity may be included in Restricted Mode, as well as kissing or affection that's not overly sexualized or the focal point of the video."

...

"We know there is a risk that some important content could be lost if we were to apply these rules without context. We value stories where individuals discuss their personal experiences and share their emotions. Sharing stories about facing discrimination, opening up about your sexuality, and confronting and overcoming discrimination is what makes YouTube great, and we will work to ensure those stories are included in Restricted Mode. "

The Google-owned website admits that the mode might still not work perfectly despite the tweaks that it made, but it promises that its systems will get better at identifying entries that should and shouldn't be filtered out over time. In addition to making guideline changes, YouTube is introducing a permanent spot on its US spotlight channel for LGBTQ+ videos to be refreshed weekly throughout the year. It's also teaming up with The Trevor Project to offer crisis intervention to members of the community and to prevent LGBTQ+ youth suicides.

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YouTube says LGBTQ+ video censorship won't happen again - Engadget

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