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Category Archives: Transhuman News

Data-driven personalized medicine takes center stage at US biotech conference – The Korea Herald

Posted: June 22, 2017 at 4:45 am

SAN DIEGO The recent explosion in data generation combined with fast-improving analytic technologies are beginning to revolutionize the field of medicine and health care, bringing closer the era of precision medicine.

Precision medicine, also referred to as personalized or individualized medicine, is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment and lifestyle for each person, according to the US National Institutes of Health.

And its one of the hottest buzzwords in the medical biotech industry today, highlighted at the seminars and conferences that took place on the sidelines of the four-day Bio International Convention in San Diego from Monday to Thursday.

This may not come as a surprise, as San Diego is dubbed the genomics capital of the world for housing companies and academic institutions with strong capabilities in genomics, a field that involves mapping out the human gene to help understand and treat disease, as well as computing technologies.

If we can just do early predictions of heart disease and cancer (the two leading cause of death among men and women), we can have a profound effect on changing the longevity curve, Venter said as he presented the work of one of his companies, Human Longevity, at the conference on Thursday.

The San Diego, California-based company is compiling a large database of DNA and clinical information to find ways to extend the human lifespan by predicting disease.

It runs a $25,000 physical exam, dubbed the Health Nucleus which includes whole genome sequencing and whole body MRI imaging. The exam amasses personalized data totaling about one petabyte of medical information, analyzed via machine learning algorithms, to pinpoint signs of deadly diseases like cancer and Alzheimers.

So far, 103 people have received the exam, through which several have discovered cancer, brain tumors and liver disease that might otherwise have been left unnoticed and untreated, said the founding chairman of Human Longevity.

As the costs of genetic sequencing continue to freefall, personalized diagnostic services are expected to become more mainstream in the health care realm in the coming years.

Earlier this year, Illumina, the worlds biggest maker of DNA sequencing machines, introduced a new machine that is expected one day to allow for a genome to be sequenced for under $100. Less than a decade ago, full genome sequencing had cost several millions of dollars.

Academic institutions are engaged in similar efforts to amass a large collection of health data with the hope of developing an improved and more precise reference of human health.

Lloyd Minor, dean of the Stanford University School of Medicine shared how the university has partnered with the Duke University School of Medicine and Verily Life Sciences to initiate the Project Baseline study.

The study will enroll 10,000 participants and follow them for four years to collect data recorded via clinicians, self-reports and bio-specimen samples. This baseline map of human health will then be used to understand the transition from health to disease, according to Minor.

What will come out of this study can be used for biomarkers associated with new types of cancer, or a new novel area of the genome. That can then be tested in a larger group of people that are not undergoing a screen everything approach, he said.

Other panel discussions revolved around topics like the path from big data to precision medicine which addressed the challenges of translating the tsunami of genetic and biomedical imaging data into actionable knowledge for researchers, drug developers and clinicians.

Other eye-catching sessions revolved around the opportunities and challenges that artificial intelligence using computers to rapidly and intelligently analyze big data and generate insights poses on the biopharma value chain.

Organized by the Biotechnology Innovation Organization, the annual Bio International Convention is a major biotech and pharmaceutical industry event for networking, business meetings and seminars. This years edition took place for four days in San Diego.

By Sohn Ji-young, Korea Herald correspondent (jys@heraldcorp.com)

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The power of a billion: India’s genomics revolution – BBC News

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BBC News
The power of a billion: India's genomics revolution
BBC News
At the same time, there's a growing interest in developing new, more effective therapies tailored to an individual's genetic makeup - an idea known as precision or personalised medicine. Missing out on mapping worldwide genetic diversity is a big ...

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Researchers target gene to treat inflammatory bowel disease – Medical Xpress

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June 21, 2017 by Becky Freemal Treatments targeting a gene known as NLRX1 could help provide relief to the estimated 1.6 million Americans currently suffering from inflammatory bowel disease. Credit: Virginia Tech

Researchers at the Biocomplexity Institute of Virginia Tech have discovered a new therapeutic target for inflammatory bowel diseaseand it's right inside our immune cells.

The research at the Nutritional Immunology and Molecular Medicine Laboratory (NIMML), at the Biocomplexity Institute of Virginia Tech, targeted the gene known as NLRX1 as one that has potential therapeutic effects to aid in the treatment of gastrointestinal inflammation.

This investigation into how immunology and metabolism interface may hold critical answers for next generation nutritional immunology. The findings from the team's most recent research were published in the Journal of Immunology.

It's this sort of discovery that has the potential to customize healthcare for the individual, from personalized nutrition to precision medicine. The team uncovered new mechanistic insights into the role of NLRX1, targeting cellular metabolism and offering new therapeutic possibilities beyond traditional targets in autoimmune disease treatment.

"For decades, immunologists have applied reductionist approaches to studying the smallest details of the immune response without considering crucial system-wide interactions with nutrition and metabolism," said Josep Bassaganya-Riera, director of NIMML, a professor of immunology, and CEO of BioTherapeutics. "Our laboratory has built predictive computational and mathematical models and artificial intelligence pipelines capable of analyzing complex, massively interacting systems, including interactions between immunity and metabolism. This study not only elucidates novel mechanisms of immunoregulation in IBD, but it also validates transcriptomic and computational modeling studies that predicted the importance of NLRX1 in regulating gastrointestinal inflammation and its potential as a therapeutic target for infectious and immune-mediated diseases."

Due to an incomplete understanding of how NLRX1 works to decrease inflammation, scientific attempts to target this molecule as a treatment for the disease had previously stalled. The lab team's findings provide a deeper understanding of this gene's role in mucosal immunity and metabolism. This levels the playing field for both nutritional interventions that target NLRX1 and the development of NLRX1-based drugs.

"This seminal work, while impactful independently, sets the stage for the next lines of applied investigation on the role of NLRX1 in IBD," said Andrew Leber, scientific director of BioTherapeutics. "It highlights the need to understand not only the immediately relevant pathways for novel immunoregulatory genes, but their global effect on all of the cohesive metabolic and immunological processes within a cell, a goal that we will continue to pursue."

This work builds upon NIMML's successful track record in leading innovative transdisciplinary research at the interface of nutrition, immunity, and metabolism that dates back to its founding in 2002. The NIMML team has been involved in establishing spinoff companies that translate new scientific discoveries into the development of marketable products that address unmet consumer or clinical needs.

Explore further: Solving the immunity puzzle takes collaboration among different fields

More information: Andrew Leber et al. NLRX1 Regulates Effector and Metabolic Functions of CD4T Cells, The Journal of Immunology (2017). DOI: 10.4049/jimmunol.1601547

Studying the human immune system is like trying to work a vast, multidimensional jigsaw puzzle with pieces that are constantly changing shape. Billions of microbes interact with the host, shaping the processes that keep us ...

UNC Lineberger Comprehensive Cancer Center researchers have discovered that a deficiency in a key protein that regulates immune system warning signals could be a new biomarker for colorectal cancer, the second largest cancer ...

Scientists at the University of North Carolina (UNC) School of Medicine and Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a human (host) protein that weakens the immune response to HIV and other ...

The human immune system is a double-edged sword. While it is finely adapted to fighting potentially deadly viruses, such as the H1N1 influenza, the mechanisms it uses to fight pathogens can have negative effects such ...

Building on previous work with the botanical abscisic acida, researchers in the Nutritional Immunology and Molecular Medicine Laboratory (NIMML) have discovered that abscisic acid has anti-inflammatory effects in the lungs ...

The Nutritional Immunology and Molecular Medicine Laboratory (NIMML) research team at Virginia Tech has discovered important new information on the efficacy of conjugated linoleic acid (CLA) in treating Crohn's disease, a ...

Scientists from St. Jude Children's Research Hospital and Fred Hutchinson Cancer Research Center have developed an algorithm that functions like a Rosetta Stone to help decipher how the immune system recognizes and binds ...

Researchers at the Biocomplexity Institute of Virginia Tech have discovered a new therapeutic target for inflammatory bowel diseaseand it's right inside our immune cells.

A subpopulation of immune cells that normally fend off pathogens can turn against the host during certain infections, a new study publishing on June 20 in the open access journal PLOS Biology reveals.

In recent years, immunotherapy, a new form of cancer therapy that rouses the immune system to attack tumor cells, has captivated the public's imagination. When it works, the results are breathtaking. But more often than not ...

Exposure to sunlight releases a compound from the skin that can alleviate symptoms of eczema, research has found.

Racial discrimination experienced by African-American children and young adults exacerbates a type of asthma known to be resistant to standard treatment, according to a study headed by researchers at UC San Francisco.

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Mayo Clinic Ventures funds new cancer-fighting cell, gene therapy – Post-Bulletin

Posted: at 4:45 am

SAN FRANCISCO, Calif. Mayo Clinic Ventures has partnered with a California-based company to make cancer-fighting gene therapies available to the public.

Vineti, a pioneering cell and gene therapy software and analytics company, announced Tuesday that it had completed its initial round of funding raising $13.75 million aimed at delivering "the first cloud-based software solution to improve patient access, accelerate life-saving treatment delivery, and promote safety and regulatory compliance for individualized cell therapies."

The funding was provided by Mayo Clinic Ventures, GE Ventures, DFJ and LifeForce Capital. It's just the 15th company that Mayo Clinic Ventures has backed since it was formed, according to Andy Danielson, vice chairman of Mayo Clinic Ventures.

"One thing with Vineti that we liked is that we have a commitment to cell and gene therapies at Mayo," Danielson told TechCrunch.com. "Vineti will make the gene and cell therapy production process more efficient and as a result, less costly. It's all part of the equation of making these therapies more affordable and opening them up to a greater number of people."

The targeted cancer therapy under development by Vineti is part of a thriving field that conducted more than 800 clinical trials in 2016 while investing nearly $6 billion. It's all aimed at positively impacting the oncology field, the largest market in medicine that's expected to grow to $165 billion by 2021.

The first two cell therapies are expected to hit the market later this year.

Vineti touts its plans as one that "integrates logistics, manufacturing and clinical data to improve product performance overall and enable faster, broader access for patients."

"Physicians, medical researchers and pharmaceutical companies are working together to develop successful therapies, transitioning from a one-size-fits-all model to individualized treatments for each patient," said Amy DuRoss, CEO at Vineti. "Now, the process for creating and delivering these treatments can be as innovative as the therapies themselves. We are developing the Vineti platform to help these treatments reach the patients who need them the most, and are confident the partnership between our advances technologies and leading medical research will deliver better outcomes across the globe."

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Steve Bannon’s politically incorrect comment on Sean Spicer’s promotion has the left in absolute turmoil – BizPac Review

Posted: at 4:44 am

When it comes to the Trump administration, liberals have no sense of humor, unless they are the ones doing the skewering.

Case in point,White House chief strategist Steve Bannonsreaction when askedwhy White House press briefings are sometimes held off-camera in reporting that press briefings are now shorter, less frequent, and routinely held off-camera, The Atlantic asked Bannon to comment.

Opting to have a little fun, he joked in a text message: Sean got fatter.

The jest was directed at White House press secretary Sean Spicer, who is reportedly being promoted to a position that oversees the entire White House communications operation.

Nonetheless, Bannons reply sent the left into a tizzy.

Even Chelsea Clinton got in on the act, accusing the presidents aide of fat shaming.

Its bad enough that CNNs Jim Acosta had a conniption over the briefings not being televised Spicer has been favoring off-camera press gaggles, with Acosta calling him kind of useless but Bannons politically incorrect reply really upset the left.

And fromMSNBC tool Kyle Griffin:

The best response to poor Griffins indignation may be this reply, which proves that some have retained their funny bones:

The hatred of Bannon is so strong, some even took to sticking up for Spicer, believe it or not while fat shaming Bannon!

Right.

Despite all the hand-wringing from social justice liberals out to save the world from itself, the kerfuffle may be best summed up in the tweet below only 7 1/2 years to go!

Tom is a grassroots activist who distinguished himself as one of the top conservative bloggers in Florida before joining BizPac Review.

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Trump thanks teens for ‘standing up’ to yearbook censorship – USA TODAY

Posted: at 4:44 am

USA Today Network Mike Davis, Asbury Park (N.J.) Press Published 7:24 a.m. ET June 21, 2017 | Updated 21 hours ago

Grant Berardo, a Wall High School junior, saw his image digitally altered with a plain black T-shirt in his yearbook. Mike Davis

Grant Berardo's T-shirt was digitally altered in the Wall (N.J.) High School yearbook. He wore a Donald Trump campaign shirt for his portrait. On Thursday, June 15, 2017, the school district superintendent said the yearbooks will be reissued.(Photo: Provided by Joseph Berardo Jr. via Asbury Park (N.J.) Press)

WALL, N.J. The scandal over censorship of merchandise and quotes from President Trump in a New Jersey high school yearbook has reached the White House.

President Trump and the director of his campaign thanked Wall High School students Montana and Wyatt Dobrovich-Fago, who reported a quote and logo featuring Trump's name removed from their class yearbooks.

The campaign also sent the teenagers a care package with shirts, hats, pins and patches.

More: Trump shirt censored, now school has to re-issue yearbook for everyone

"Thank you Wyatt and Montana two young Americans who arent afraid to stand up for what they believe in. Our movement to #MAGA is working because of great people like you!," Trump posted on Facebook.

In a letter, campaign executive director Michael Glassner commended the students for "voicing their support" for Trump.

"It is more important than ever that we, as Americans, stand up for our beliefs and hopes for a better country," Glassner wrote. "And, as you know, it takes courage to do so. But freedom of expression should never go out of style let's not forget that!"

Wyatt, a junior at the school, wore a sweater vest featuring a Trump campaign logo on the school's picture day. But in the yearbook, his photo was cropped and the logo was barely visible an act Superintendent Cheryl Dyer has ruled was not intentional.

More: N.J. teacher suspended over Trump yearbook censorship

His sister, Montana, picked a quote from Trump to run alongside her freshman class president photo: "I like thinking big. If you are going to be thinking anything, you might as well think big," Trump's quote read.

Traditionally, all Wall class presidents can pick a quote. Montana's was submitted before the deadline and it's not yet clear whether it was purposely excluded, Dyer said last week.

Another student, junior Grant Berardo, saw his picture digitally altered before being published in the yearbook. Instead of the navy blue Trump campaign shirt he wore during the photo shoot, his yearbook photo featured a nondescript black T-shirt an "intentional" alteration, Dyer ruled.

The school board Tuesday voted to formalize a suspension handed down to digital media teacher Susan Parsons, who Dyer suspended through the end of the school year last week.

The board is expected to continue discussing the case in executive session at future meetings, board attorney Michael Gross said.

Parsons, 62, was included on a list of re-hired teachers for the 2017-18 school year with a $92,000 salary, but that list was finalized before the yearbook censorship came to light.

More: Teen's Trump T-shirt censored in yearbook photo

She has not returned multiple calls to her home seeking comment.

In response to the censorship scandal, Dyer last week ordered new yearbooks to be printed and reissued. Private, anonymous donors have contributed "at least $10,000" to cover the cost, Dyer said after Tuesday's board meeting.

But some members of the Wall school community have said it's not enough. Dyer has come under fire for handling the investigation despite last year posting a New York Times opinion article about "bullying in the age of Trump" on the school website.

Wyatt also criticized Dyer for the "blatant anti-Trump stuff that's caused concern" for him.

"I feel like there's something else to the story. One person wouldn't just do this," Wyatt said. "There needs to be a proper investigation into this."

School Board President Allison Connolly disagreed, applauding Dyer and district administrators for "facing this situation head-on."

"We find the allegations of censorship disturbing and are taking the charges that students have had their rights compromised seriously," she said.

Follow Mike Davis on Twitter:@byMikeDavis

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Disrupting ‘Caesar’ play mostly about censorship – The Register-Guard

Posted: at 4:44 am

The show must not go on.

So sayeth some of President Trumps most ardent fans, who spent the past week and a half attempting to shut down a production of Julius Caesar with a Trump-like character in the title role.

These Trumpkins part of a bloc known for mocking political correctness, safe spaces and undue efforts to avoid offending the pwecious feewings of others deemed the show politically incorrect, unsafe and offensive.

Peaceful protest would be well within their rights. But these illiberal cultural illiterates instead wanted curtains for the offending Elizabethan play.

They stormed the stage at multiple shows, including Sunday evenings closing performance. They yelled and screamed inside and outside the open-air production part of the Public Theaters annual Shakespeare in the Park series to drown out dialogue they disliked. They threatened violence, sometimes quite graphically.

Some even sent death threats to other productions of Shakespeare and other plays in other parks.

In this, they are more like Caesars plebeian partisans than they may realize: It is no matter, his names Cinna, a member of a murderous mob cries in Act III, Scene 3 of the play, before tearing apart an innocent poet with the bad fortune to bear the same name as a perceived enemy of the state.

The justification for these present-day disruptions and threats is that, at least according to (wrong) right-wing media reports, the production advocates assassination of a Trump-like Roman tyrant. But the only people lately threatening political violence in the name of Julius Caesar are those who wanted to shut this play down.

If these reactionaries had actually thought about the play, theyd realize its portrayal of the aftermath of assassination offers the opposite lesson: that those who attempt to defend democracy by undemocratic means pay a terrible price and destroy the very thing they are fighting to save, as the Public Theater put it in a statement to theatergoers.

Theres a part of me that wants to rejoice that, 168 years after New Yorks Astor Place riots (also inspired by a contentious interpretation of the Bard), the theater can still be a source of so much controversy. In recent months not just Julius Caesar but also Hamilton has brought a raucous and artistically challenging rialto to the center of national social discourse.

Still, needless to say, death threats are not the type of intellectual engagement and social validation that most theater nerds were looking for.

The violent rhetoric of recent days is certainly no fault of the Public, even if, in choosing to portray Caesar with blondish hair, an ultra-long tie and a Slovenian-accented paramour, it clearly intended to provoke. But then, last years Taming of the Shrew production also had a Trumpian character portrayed by a woman, no less and earned no incendiary Fox News coverage.

Nor is this debacle the fault of a few misguided protesters alone.

After all, they were just firing the latest salvo in the ongoing war against the free exchange of ideas, that most precious and endangered of liberal democratic values.

Plenty of conservatives like to believe that illiberalism is confined to liberal college students. Certainly there is evidence that millennials are at the vanguard of hostility to free speech. But as I have written time and again, attempts to stamp out speech are not confined to young or old, or left or right.

Instead, End of History be damned, there is a growing sense on both sides of the aisle, and among all generations, that the free marketplace of ideas is broken. Everyone seems to believe that the inferior and dangerous ideas of their enemies are unfairly gaining ground; therefore, the words and beliefs of those enemies must be fair game for suppression.

And yes, attempts to shut down Julius Caesar like attempts to shut down conservative campus speakers are about objections to words and beliefs. They are not about protecting politicians or vulnerable minority groups from physical harm, despite the claims of would-be censors.

If this were really about blocking public entertainment that put lives at risk, youd find more Trump fans and college students alike disrupting football games.

In Julius Caesar, Shakespeare hinted that he expected his play to offer lessons for generations to come, though perhaps not the ones his characters believe they are offering.

How many ages hence/Shall this our lofty scene be acted over/In states unborn and accents yet unknown! declaims Cassius, after proudly smearing himself with the slain Caesars blood.

Censors willing, lets hope Cassius prediction continues to hold true.

Catherine Rampell (crampell@washpost.com) was a reporter for The New York Times and The Chronicle of Higher Education before joining The Washington Post as a columnist.

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EXCLUSIVE: Judd Apatow on ‘The Big Sick’ and Clean Movies Censorship: ‘It’s Pretty Sleazy’ – 9NEWS.com

Posted: at 4:44 am

John Boone , ET 10:00 AM. MDT June 21, 2017

Mentorship is not a new hat for Judd Apatow -- after all, he's the guy who helped guide a then-unknown Lena Dunham and Girls to success. Lately though, he's only increased his efforts, with Pete Holmes on Crashing, Paul Rust on Love and now Kumail Nanjiani's first feature film, The Big Sick.

"I think it's among the best movies we've ever been a part of," Apatow says of The Big Sick, out June 23. "It's scary to come out in the summer against all these behemoths, but there's always room for one movie that people go see just because it's awesome. We're hoping that there's a little sleeper appeal."

I sat down with Apatow at the Four Seasons in Beverly Hills, along with fellow producer Barry Mendel (who produced Apatow's Funny People, This Is 40 and Trainwreck, as well as Oscar-nominated films The Sixth Sense and Munich), to discuss their movie and Sony's now-scuttled "clean" movies initiative, which Apatow denounced on Twitter, saying, "Shove the clean versions up your a**es!"

RELATED: How Kumail Nanjiani and Emily V. Gordon Turned Their Heartbreak and Happiness Into 'The Big Sick'

ET: You both have had long careers, including numerous movies you've worked on together. In terms of looking for projects, what do you find inspires you these days?

Judd Apatow: I like human comedies -- or dramedies. More than anything, I'm interested in people just dealing with everyday things that are difficult, and there is more than enough comedy and drama in that. Every once in a while it's fun to do something big and silly, so I also really enjoy when I get a chance to work with Will Ferrell and Adam McKay or with the Lonely Island guys. But I'm always fascinated by people dealing with the everyday difficult stuff in life.

Barry Mendel: For me, it's like, I forgot who said it -- it was maybe Jesse Helms? -- about pornography: "I don't how I describe it, but I know it when I see it." [Laughs] I'm more that way. I don't really have a philosophy about it. In this case, when Kumail came in and told us the story of what happened with Emily, it was just like, "Wow." Just, like, the light goes on.

Do you think a project can ever be too autobiographical?

Apatow: I think the key is that you have to always be aware that it's a movie. The audience doesn't care that most of this happened. They just want a good movie. During development, we definitely said, "Well, that's what happened, but it's kind of boring. So, maybe we could spice that up a little bit." [Laughs] We're not presenting this as an 100 percent accurate story. It's just the inspiration for our movie.

Many of your movies also draw inspiration from your life. Is that something you had to wrestle with in your writing, writing what you know but not being confined by the historical details?

Apatow: I just never thought anything about me was interesting, so I didn't think about writing from my personal experience.

Mendel: It's almost like the opposite journey, of writing about things that were fantastical and moving towards the personal.

Apatow: Yeah, and I think a lot of people do that! It's why people like Louis [C.K.], after decades of work as he got more and more personal, people connected with it more. It's always a big mix between fabricated and real things, as it should be. I mean, it's the only fodder you have to create with.

You are both known for nurturing young talent. And obviously that talent is what catches your eye, but what does someone like Kumail do to keep you invested?

Apatow: I think that he works so hard. I like working with people on their first movies. I think that you never get that level of effort again. And I think that most people only have a couple of amazing stories from their lives, so you're getting the best of them. And I like the passion that people have when they're trying to prove they can make a movie or be a movie star. Later in your career, you just get offered a script and maybe you get a week or two to punch it up, and maybe they rehearse it for a day before they shoot, and that's why a lot of movies don't come out well. But when you do something like this, where we developed it for three or four years before we shoot it, there's so much love and care that goes into it. That's what I like! I like being at the moment of inception for people.

Mendel: I would say Kristen [Wiig on Bridesmaids], Amy [Schumer] and Kumail had never written a script before, so they're panicked every night. They're waking up in the middle of the night with ideas and writing them down. It's like they can't believe they're getting paid to do it. It's not a job. It's the greatest thing that ever happened to them. So, it's so great for us to get to work with people who have that vibe about what we're doing. It refreshes our experience of what we do.

Apatow: Because when you're making your 20th movie, it might be the 20th most incredible thing that's ever happened to you! [Laughs]

Judd, how do you balance producing those projects with writing and directing your own?

Apatow: It always energizes me with my own work. It's always a reminder how much I should care and how truthful I can be. I think in the last few years, I haven't been able to write as much, because I've been working on the TV show with Pete Holmes, Crashing, and Love on Netflix. But that's OK, because I think the world is changing and all that matters is that I'm creating things.

Mendel: You're also working on your third documentary.

Apatow: Yes. I'm working on a documentary about Garry Shandling right now and we have a documentary about the Avett Brothers that's going to be on HBO in January. So, I've been enjoying that format. I'm just happy to make stuff. Ultimately, I don't think it matters what the frequency is of me writing or directing a movie. It doesn't really matter to anybody else. I'm just trying to put good things out there.

You recently called Sony Pictures' clean movies initiative "absolute bullsh*t." What would something like that mean for your movies? [Two films that Apatow produced, Talladega Nights: The Ballad of Ricky Bobby and Step Brothers, were of the first films Sony made clean versions of.]

Apatow: Well, it goes against everything you want in your relationship with a studio. The most important agreement you have is that they will not f**k with your movie once it's done. And so it's pretty sleazy to say, "We're going to take the version of the movie you like the least and try to distribute it to even more people." When you edit a movie for television or for an airline, you're doing it very reluctantly. And you don't want people to watch it that way! But it is part of the business that you can't prevent. It preceded you. But they're trying to create a new initiative, and we're allowed to say, "No. We've agreed to ruin our movies for television and airlines and we're hopeful that due to streaming, most people aren't watching it in those formats. We do not want to spread it." And our movies were not built to be made for children. That's the other weird part about it is, Now I can show it to six year olds! Well, even the essence of it isn't meant for six year olds, or whoever you're marketing it to. But it's a real violation of the spirit of our creative relationship, and I'm assuming that they will quickly realize it and not do it.

That basically answers my last question, which was you have the theatrical release and then sometimes an extended or unrated cut. Is there a way to make a PG or PG-13 version of your movie that you'd be happy with?

Apatow: That's not even the question. The question is, Whose decision is it? I could edit it to, like, a six minute short if I want to! But that becomes the decision of the filmmaker. If Martin Scorsese wants to do a 14-minute, clean Wolf of Wall Street for kindergarteners, I guess he should be allowed to do it. But certainly the head of the studio shouldn't be allowed to do that without his approval. That's the issue. And I do think it will get quickly resolved.

Mendel: In France they call it, Le Droit Moral.

Apatow: What does that mean?

Mendel: The moral rights. Of the artist. The artist is implied in the French version.

I kind of want to see that Wolf of Wall Street for kindergarteners. I think if you edited out any scene with swearing or nudity, it would only be 14 minutes anyway.

Apatow: [Laughs] Exactly. I remember watching Goodfellas on a plane once, and every time they said the C-word, instead they would say "Bundt cake." And you could tell it was kind of an eff you from someone in the Scorsese world. Actually, you know what it was? It was Glengarry Glen Ross. [Directed by James Foley.]

Mendel: We did it on Rushmore, too. We did "foot rub" for "handjob." Every time it said "handjob," we just said "foot rub."

Apatow: I think we had one where we were trying to replace every curse in the entire movie with the word "tomato."

[Note: As Apatow predicted, Sony Pictures Home Entertainment soon after announced they would no longer release the "clean version" of a film if the director objected, claiming, "We believed we had obtained approvals from the filmmakers involved for use of their previously supervised television versions as a value added extra on sales of the full version."]

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EXCLUSIVE: Judd Apatow on 'The Big Sick' and Clean Movies Censorship: 'It's Pretty Sleazy' - 9NEWS.com

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Ron Paul: The Fed’s actions will soon cause a long-overdue …

Posted: at 4:43 am

Former Rep. Ron Paul, who has run for president several times, is predicting the Federal Reserve's actions will have serious consequences for the stock market, just as the latest growth figures suggest the economy may have hit a soft patch.

According to government figures released on Friday, the nation's gross domestic product fell to 0.7 percent in the first quarter the lowest rate in three years as personal spending slid to its worst level since 2009. That data came on the heels of a jobs report that showed the economy created far fewer jobs in March than the prior month, even as the unemployment rate fell.

Paul told CNBC a correction is "inevitable," even as investors cheer the Nasdaq composite's new record highs.

"We spend too much, we borrow too much, and we distort the markets," Paul said on "Trading Nation" this week. "The bigger the distortions have lasted, the bigger the bust will be."

The Federal Reserve holds its meeting on interest rates the first week in May. Wall Street doesn't predict a rate hike this time, but the consensus still calls for two more rate hikes this year.

In coming months, the Fed also plans to unwind its balance sheet, which holds $4.5 trillion in bonds.

But Paul, a Republican known for his libertarian policies, predicted it will be too little, too late. He warned the Fed is going to push the economy over the edge and should have let the market determine the rate of interest.

"It has been especially bad in the last 10 to 15 years. I mean they have driven these interest rates so terribly low, and everybody was recognizing it even when Greenspan was there," said Paul. He said the Fed is likely to unwind during a market downturn.

"There's enough evidence around it even though there's some euphoria on Wall Street. I still think there are serious problems in the economy," he added.

Paul said the main problems are "uncontrollable spending" and financial issues affecting the middle class.

"When monetary policy destroys the currency, it always destroys the middle class," he said.

Not even the Nasdaq's historic milestone is altering Paul's read on the markets. The index broke 6,000 this week for the first time ever.

"All you have to do is go back to the year 2000, and the Nasdaq was at 5,000. And now it's all the way up to 6,000, after what, 17 years?" asked Paul, who's been invested in gold.

"Gold back then was less than $300, and it's $1,200. So I would say gold has done very, very well in that period of time," Paul said. "And besides the 20 percent increase in the Nasdaq, if you discount for the inflation ... that's not the greatest investment in the world. "

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‘US should mind its own business; it shouldn’t be in Syria’ Ron Paul – RT

Posted: at 4:43 am

Published time: 21 Jun, 2017 12:53

The US has no right to fly into Syrian airspace where it shouldnt be and set boundaries but should mind its own business. Otherwise, it is an act of aggression, says former US Congressman Ron Paul.

The US fighter jetdownedan armed drone belonging to pro-Syrian government forces in southern Syria, near a base in the al-Tanf region, on June, 20 as the drone was advancing on US-backed forces, according to a coalition statement.

This is happening at a time of escalating tension between Moscow and Washington. Also on Tuesday, Australia said it is temporarily suspending air operations in Syria.

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RT discussed the latest developments in Syria with former US Congressman Ron Paul.

RT:Australia halted its cooperation. How significant is this development? Why did they do it?

Ron Paul:I think that is good. Maybe wise enough, I wish we could do the same thing just come home. It just makes no sense; theres a mess over there. So many people are involved, the neighborhood ought to take care of it, and we have gone too far away from our home. It has been going on for too long, and it all started when Obama in 2011 said:Assad has to go.And now as the conditions deteriorate it looks like Assad and his allies are winning, and the US dont want them to take Raqqa. This just goes on and on. I think it is really still the same thing that Obama set up Get rid of Assadand there is a lot of frustration because Assad is still around and now it is getting very dangerous, it is dangerous on both sides. One thing that I am concerned about - because Ive seen it happen so often over the years are false flags. Some accidents happen. Even if it is an honest accident or it is deliberate by one side or the other to blame somebody. And before they stop and think about it, then there is more escalation. When our planes are flying over there and into airspace where we shouldnt be, and we are setting up boundaries and saydont cross these lines or you will be crossing our territory.We have no right to do this. We should mind our own business; we shouldnt be over there, when we go over there and decide that we are going to take over, it is an act of aggression, and I am positively opposed to that. And I think most Americans are too if they get all the information they need.

RT:Russian Foreign Minister Sergey Lavrov said earlier that he wanted to ask his American counterpart why the US-led coalition isnt targeting Al-Nusra in Syria. What sort of answer do you think hell get?

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RP:I think it will be wishy-washy. Hell probably think it is in their interests not to do anything to damage the radicals, the extremists, the rebels because I think that our government thinks that they could be helpful in undermining Assad. I dont think they are going to sayYeah, they are our buddies now, we consult with them all the time.It wont be that. Theyll argueWe have to help the Kurds outor something along those lines and make excuses. I think that theres a net benefit to the radicals for us to get involved there and it is not helpful in the long run for our position which ought to try to bring about peace.

The propaganda the American people hear is such that they get them pretty excited about it, but I am very confident that if the American people had more informationbecause when I talk to them, they side with my arguments. It doesnt make a whole lot of sense to be doing what we are doing, and thats why I persist in trying to get to the facts but trying to eliminate the danger, try to obey international law, try to do the things that are in our best interest. And if we are talking about Americas interest it isnt helped by our policy in the Middle East for the last 15-20 years, I think it has all been negative.

Richard Black, Republican member of Virginia State Senate, told RT that"the US and the coalition are in Syria without any permission, without any lawful authority to be present".

"Some members of the coalition may say We are in clear violation of international law, maybe this is not right. Others bought into this coalition to be part of a group fighting ISIS, and now they are saying Wait a minute. We didnt go into Syria to fight the legitimate duly elected government of Syria; we went there to fight this terrorist organization.The coalition is certainly not there to help the Syrian people; it is there to help Saudi Arabia with its Wahhabi radical Islamic domination of the entire world beginning with the countries close to it".

The statements, views and opinions expressed in this column are solely those of the author and do not necessarily represent those of RT.

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