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Category Archives: Transhuman News
Cat Zingano on fighting Holly Holm next: ‘Hell yes’ – MMA Fighting
Posted: June 22, 2017 at 4:46 am
While Cat Zingano continues down the road to recovery, she cant help but think about whats next.
First, she expressed interest in fighting Cris Cyborg Justino at a later date. But after Holly Holms impressive win over Bethe Correia last Saturday in Singapore, the former UFC womens bantamweight contender said shed be interested in fighting Holm, too.
I'm excited to see Holly do as well as she did against Bethe, Zingano said. I'm always a fan of watching (Bethe) get humbled, in that case it was instant. You have to give it to Holly, she's amazing at implementing a gameplan.
Recently, I was asked about fighting her and for it to be in contention of possibly fighting the winner of Cyborg (Justino) vs. (Megan) Anderson. My answer is hell yes. As soon as my body is ready to safely go back in there, the heads will be rolling once again. The results and trials of the treatments Im focusing on are responding and that makes me happy to hear as an athlete, as well as a normal human. Longevity in health and sport are both my top priorities, as well as in the interest of the UFC, who is providing me huge support at this time.
Zingano declined to disclose whats ailing her right now and said shes unclear when she can return just yet because its dependent on these treatments.
The 34-year-old Zingano (9-2) hasnt fought since UFC 200 last July. She hasnt won since UFC 178 in September 2014 when she defeated Amanda Nunes, who is now the UFC womens bantamweight champion.
Justino vs. Anderson, for the now-vacant UFC womens featherweight title was officially booked earlier this week for UFC 214 on July 29.
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Cat Zingano on fighting Holly Holm next: 'Hell yes' - MMA Fighting
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Men With This Genetic Mutation May Live 10 Years Longer – – Vital Updates
Posted: at 4:46 am
Males with a singular genetic mutation are likely to live about 10 years longer than their peers without the change, shows a new study appearing in the journal Science Advances.
Researchers have linked a mutation in the growth hormone receptor (GHR) gene to longer life in a number of populations, ranging from Ashkenazi Jews to Pennsylvania Amish.
Our study provides the first consistent evidence linking the GHR to human longevity, report the study authors from the Albert Einstein College of Medicine in New York City and other institutions.
The authors believe that their findings may support interventions on a genetic level that can impact the human lifespan.
These results may have implications in devising precision medicine strategies, such as GH-related interventional therapies in the elderly, the authors write.
The new findings come as one of the first clear associations between a populations genetic makeup and overall lifespan. Much previous work on population-level DNA has come up empty.
Its been a real disappointment, Nir Barzilai, a geneticist at Albert Einstein College of Medicine who led the current study, told the New York Times.
Yet researchers have begun to take cues from approachable physical evidence, rather than first burrowing deep into the genome to try to find the magical gene thats tied to a longer life.
Related:Running May Increase Life Expectancy
If you look at dogs, flies, mice, whatever it is, smaller lives longer, Gil Atzmon, a geneticist at the University of Haifa in Israel, explained to the New York Times.
That observation has led researchers to investigate growth hormone, a substance created in the brain that is directly tied to human growth and size. At a microscopic level, growth hormone attaches to cell molecules via the growth hormone receptor, and this connection guides the ability of the body to keep or stop growing.
The next step in comparing a persons size to longevity took the researchers on a course through history.
The researchers decided to investigate a specific population Ashkenazi Jews (AJ), whose history gave the researchers something of a clean slate from which to work.
To a large extent, this population exhibits both cultural and genetic homogeneity. For these reasons, the AJ population has been successfully used in the discovery of many disease-associated genes, report the study authors.
Among this population, most of whom were born or migrated to the United States in the years preceding World War II, the link between the GHR gene and longevity held true the genetic mutation was present in about 12 percent of men who were over the age of 100. Among those 70 years old, the rate of the GHR mutation was about three times less.
When observing data from an Amish population in Pennsylvania and a group of notably long-living people in France, the researchers found the same genetic trends the GHR mutation was again linked to longevity.
Although numerous genes have been shown to influence longevity, certain genes appear to affect life span across diverse organisms, conclude the researchers, who believe that plausible therapies are not too far off.
Richard Scott is a health care reporter focusing on health policy and public health. Richard keeps tabs on national health trends from his Philadelphia location and is an active member of the Association of Health Care Journalists.
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eczema in children – ACAAI – ACAAI Public Website
Posted: at 4:45 am
Eczema, also known as atopic dermatitis, is often associated with food allergy; approximately 37 percent of young children with moderate to severe eczema also have food allergies. However, scientists are still investigating the exact nature of this relationship do food allergies cause eczema or vice-versa?
Eczema is a non-contagious, inflammatory skin condition that is characterized by itching, redness, and scaly rashes. These symptoms can be painful, cause skin coloring changes, and blisters. Symptoms of eczema often appear on the arms, legs, hands, and face. The itch associated with eczema can be severe, often interrupting sleep. Scratching of the skin may lead to an infection. Infants who have eczema may rub against bedding or other things in an attempt to relieve the itch.
Eczema most commonly presents before the age of 5, but adolescents and adults can also develop this condition. About 60 percent of patients will experience symptoms of atopic dermatitis by age 1, and another 30 percent will experience symptoms by age 5. Children born into families that have a history of allergic diseases such as asthma or hay fever are at an increased risk for eczema developing.
Eczema is considered to be part of the atopic march. The atopic march involves the diagnosis of eczema, food allergy, allergic rhinitis, and asthma, typically in that sequential order.
There is documented association between food allergy and eczema among young children. It is recommended that children under the age of 5 who have moderate to severe eczema be evaluated for milk, egg, peanut, wheat, and soy allergies, if the child continues to have eczema even after treatment. Testing is also recommended when the child has a history of reaction after eating a specific food.4 An allergist can help identify which foods, if any, to eliminate from your childs diet.
Scientistshave found that people who have Filaggrin deficiency (Filaggrin is a protein found in the outermost layer of the skin; some people have a gene mutation that causes Filaggrin deficiency) are at risk for developing atopic eczema the presence of this gene defect is also believed to increase the risk of developing food allergy.
Children and adults diagnosed with eczema can manage this condition with the guidance of an allergist. In cases of moderate or severe eczema, an allergist may recommend prescription medication, including topical steroids and/or antihistamine. Milder cases may be treated with ointments and moisturizers. People with eczema should avoid harsh cleansers, drink water often, wear gloves in cold weather, and avoid wearing materials such as wool, which could irritate the skin.
Flare-ups of eczema can be caused by foods, cosmetics, soaps, wool, dust mites, mold, pollen, dog or cat dander, dry climate, and other variables.
Will the symptoms of eczema improve?
Eczema is a chronic condition, and the symptoms can come and go. The symptoms are treatable. Talk to your allergist about topical ointments or creams that can be applied to the skin. You can also help manage your eczema with regular moisturizing after baths and showers, avoiding things may that trigger a flare up (pollen or animal dander, for example), avoiding extremes in humidity levels, using non-perfumed soaps, and wearing loose-fitting, soft cotton clothing.
Is all eczema the same?
No. We have mainly discussed atopic dermatitis, also known as atopic eczema. Many other types of inflammatory skin conditions are also part of the eczema family. One such example is contact dermatitis, which is caused by direct contact with substances such as latex, detergents, perfumes, and a host of other allergens and substances to which an individual has developed sensitivities.
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Researchers Discover Genetic Cause for Eczema | HealthCentral – HealthCentral.com
Posted: at 4:45 am
Researchers Discover Genetic Cause for Eczema
Credit: iStock
A research team from the National Institute of Allergy and Infectious Diseases and other institutions has identified a genetic mutation that causes eczemaa chronic skin condition also called atopic dermatitis. This discovery could lead to better treatments for atopic dermatitis.
Eczema affects up to 30 percent of the U.S. population and often occurs in young people alongside asthma, hay fever, or other allergies. Its thought to be caused by a combination of environmental and genetic factors.
For the study, researchers analyzed gene sequences in eight people with severe eczema from four families that had a specific mutation of a gene, called CARD11, that affects the immune systems response to infection. In addition to linking the mutation with eczema, the results of the also indicate that people with mutations in the CARD11 gene can have eczema alone, without having other medical issues common in people with immune system disorders.
Sourced from; MNT
Credit: iStock
TodayJune 21stis the first full day of summer! As the heat and humidity rise and record-breaking temperatures hit in some areas of the country its important to reduce your risk for serious conditions like heat stroke. Older adults, children, and people who work outside are particularly vulnerable to the heat.
Heat-related illness usually progresses in three stages: heat cramps, heat exhaustion, and heat strokewhich is a medical emergency. To cut your risk, drink plenty of non-alcoholic beverages (water is best) and avoid strenuous outdoor activity during the hottest part of the dayusually between 11 a.m. and 4 p.m.
Symptoms that require immediate cooling measures include increased thirst, muscle cramps, headache, nausea, weakness, and agitation or anxiety. Heat stroke can be fatal and requires immediate medical attention. Signs of heat stroke include mental confusion, an absence of sweating, and reddened skin that is dry to the touch. If you suspect heat stroke, call 9-1-1.
Sourced from: NBC News
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A new study shows the number of U.S. adults who take high-dose vitamin D supplements increased significantlyfrom 0.3 percent to 18.2 percentbetween 1999 and 2014 in the U.S. According to the study, which was published in JAMA, this may be concerning. Although vitamin D is important for bone health, extremely high doses may are linked to negative health effects, including kidney stones, bone fractures, and falls.
Sunlight is the main source of vitamin D; the body produces it when the suns UV rays are absorbed by the skin. It is also found in animal productsmeat and dairyand in mushrooms. The recommended dietary allowance of vitamin D is 600 IU (International Units) in people under age 70 and 800 IU in those over 70. The upper tolerable limit of vitamin Dthe largest amount unlikely to cause harmis 4,000 IU daily for people of all ages.
For the study, researchers examined data from the National Health and Nutrition Examination Survey involving about 40,000 people. In each survey from 1999 to 2006, fewer than 0.1 percent of adults reported taking 4,000 IU or more of vitamin D supplements a day, but in the 2013-2014 survey, 3.2 percent of adults reported taking at least that much.
Sourced from: Live Science
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Researchers Discover Genetic Cause for Eczema | HealthCentral - HealthCentral.com
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6 Common Triggers for Eczema and What To Do About Them – Health.com
Posted: at 4:45 am
If you have eczema, you know that the itchy, scaly rash can pop up on any given dayand in the most inconvenient places. But even though there is no known cure for the skin condition, making small lifestyle changes can help you avoid symptoms.
Did you know that taking long, hot showers can irritate your skin? The hot water saps skin of natural oils. The same goes for harsh detergents and soaps. Try stocking up on dye-free and fragrance-free products, or try formulas specifically geared toward sensitive skin, so youre less likely to encounter an irritant. For more tips, watch the video.
Watch the video: What Causes Eczema?
Dont have time to watch? Read the full transcript:
Eczema is a skin condition with an itchy, scaly rash. The most common type of eczema is called atopic dermatitis. It usually appears on the arms or behind the knees, but it can appear anywhere on the body. Experts believe its hereditary, but its also linked to asthma and allergies. To help manage symptoms, avoid:
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6 Common Triggers for Eczema and What To Do About Them - Health.com
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Liam Gallagher says that Oasis fans tried to snort his psoriasis at … – NME.com
Posted: at 4:45 am
Liam Gallagher has recalled Oasis first Glastonbury appearance, revealing how fans of the band tried to snort hispsoriasis backstage.
The Britpop groupfirst played Glasto in 1994 and Gallagher remembered a story from that years festival in a recent interview with Noisey.
I remember coming off stage and I got my clothes robbed, Gallagher said. I [also] remember meeting someone, some very strange kid, who come up to me and thought I had cocaine in my hair.
Liam explained: I got psoriasis [skin condition that causes itchy, scaly rashes] so I had obviously been scratching it during the day and that, and there were little white bits and shit. They were takingit out of my hair and putting it on their gums and putting it up their fucking nose. I went like, Okay'.
Watch in the video below at the 2.04 mark.
Earlier today, bookies announced 12/1 odds that Liam and Noel would reunite at Glastonbury 2017.Liamis set to play The Other Stage on Saturday afternoonwhereas his brother is also due to appeartointroduce a special screening of Oasis movie Supersonic.
Elsewhere in the interview, Gallaghershared an anecdote about hanging out with Steve Cooganand gavehis take on why Oasis never fully broke America.
Liam said: I think we were a bit too laddy or English for themIm quite happy with the way it went down in America to be honest. I think if we got big in America id be a proper c*nt.
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Liam Gallagher says that Oasis fans tried to snort his psoriasis at ... - NME.com
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Novartis’ Cosentyx and Eli Lilly’s Taltz Bring Disruption to the Psoriasis Market as IL-17 Share Increases Dramatically – PR Newswire (press release)
Posted: at 4:45 am
So, what does this mean for other biologics in PsO? According to the report, Humira has seen a 16% offset to share over the past year and Enbrel has given up more than 20%. Although future projections show this erosion curve to continue, actual offsets may come at a slower pace, particularly for Humira, which is extremely well-entrenched as a first line biologic, as well as the preferred biologic for certain PsO patient types. Furthermore, AbbVie dominates when it comes to perceptions about manufacturer support for patients, providers, and the dermatology community.
Janssen's Stelara has carved out a solid position as the leading alternative mechanism biologic; however, the IL-17s are expected to catch up in the next six months, essentially flattening Stelara's growth. Indeed, among those expecting to increase their use of IL-17s, close to a third expect a corresponding decrease in the use of Stelara.
Lastly, Celgene's Otezla has maintained a solid position as a psoriasis treatment and dermatologists do project gains in patients with mild and moderate disease. However, only half of the current Otezla patients are classified as "well-managed" compared to 71% of biologic-treated patients. Furthermore, dermatologists identified multiple barriers to increased use of Otezla, including market access challenges, issues with GI tolerability, and sustained efficacy. Until additional oral small molecule products enter the psoriasis market, Otezla has the corner on a market very much in demand by patients.
The next wave of this study, RealTime Dynamix, will field in August and further drivers behind the evolution of this market will be explored next month in RealWorld Dynamix: Psoriasis, a large scale syndicated chart analysis of over 1,000 biologic/apremilast treated patients that have recently switched brands.
All company, brand or product names in this document are trademarks of their respective holders
About Spherix Global Insights Spherix Global Insights is a business intelligence and market research company, specializing in renal, autoimmune, neurologic and rare disease markets. Our aim is to apply our commercial experience and unique relationships within core specialty markets to translate data into insight, enabling our clients to make smarter business decisions.
For more information contact: Lynn Price, Immunology Franchise Head Email: info@spherixglobalinsights.com http://www.spherixglobalinsights.com
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/novartis-cosentyx-and-eli-lillys-taltz-bring-disruption-to-the-psoriasis-market-as-il-17-share-increases-dramatically-300477250.html
SOURCE Spherix Global Insights
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Novartis' Cosentyx and Eli Lilly's Taltz Bring Disruption to the Psoriasis Market as IL-17 Share Increases Dramatically - PR Newswire (press release)
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Tofacitinib Assessed for Efficacy in Nail Psoriasis – Monthly Prescribing Reference (registration)
Posted: at 4:45 am
June 20, 2017
Improvement in nail psoriasis severity at 16 weeks vs placebo; maintained through 52 weeks
HealthDay News Tofacitinib is associated with improvements in nail psoriasis, according to a study published in the July issue of the Journal of the American Academy of Dermatology.
Joseph F. Merola, MD, from Brigham and Women's Hospital in Boston, and colleagues examined the efficacy of tofacitinib for nail psoriasis treatment over 52 weeks in two identical phase 3 studies. Patients were randomized to receive tofacitinib 5 mg (487 patients), tofacitinib 10 mg (476 patients), or placebo (233 patients) twice daily. Placebo-treated patients were re-randomized at week 16.
The researchers found that significantly more patients receiving tofacitinib 5mg and tofacitinib 10mg versus placebo achieved a 50% reduction in the Nail Psoriasis Severity Index (NAPSI) score from baseline (NAPSI50) (32.8 and 44.2, respectively, versus 12.0 percent), NAPSI75 (16.9 and 28.1, respectively, versus 6.8 percent), and NAPSI100 (10.3 and 18.2, respectively, versus 5.1 percent) at week 16. The improvements were maintained to week 52.
"Tofacitinib treatment resulted in improvements in nail psoriasis versus placebo at week 16; improvements were maintained over 52 weeks," the authors write.
Several authors disclosed financial ties to pharmaceutical companies, including Pfizer, which manufactures tofacitinib and funded the study.
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Tofacitinib Assessed for Efficacy in Nail Psoriasis - Monthly Prescribing Reference (registration)
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The Unexpected Way Genes Can Double Heart Disease Risk – TIME
Posted: at 4:45 am
Its common to think of cancer as a disease driven by the buildup of mutations in the DNA of cells. Everything from pollutants to cigarettes to exposure to everyday chemicals can alter genes, and continued exposure over a lifetime can lead to a critical mass of mutations.
Now, researchers say the same process may be at work in heart disease. In a paper published in the New England Journal of Medicine, Dr. Sekar Kathiresan, from the Broad Institute of Harvard and MIT, and Dr. Benjamin Ebert from Brigham and Womens Hospital and their colleagues found a gene that builds up mutations over a lifetime and can double the risk of heart events.
MORE: Single Gene Responsible for Group of Heart Disease Risk Factors
While there are genes associated with greater heart disease risk, most of them are inherited. The new mutations linked to heart problems are among the first to be acquired, or picked up over a lifetime. The mutations develop among a group of blood cells known as stem cells, which divide throughout a person's lifetime to replenish the supply of blood cells. The genetic changes the researchers found are also linked to a higher risk of developing blood cancer, but they seem to have a stronger effect on heart disease than cancer.
This is a totally different type of risk factor than hypertension or hypercholestserolemia [high blood cholesterol] or smoking, says Kathiresan. And since its a totally different risk factor that works through a different mechanism, it may lead to new treatment opportunities very different from the ones we have for heart disease at present.
Kathiresan and his team actually found the gene several years ago when they linked it to a 10-fold higher risk of developing blood cancers. Although the mutations increased cancer risk, the cancers were still relatively rare, but people who had them had a 40% higher risk of dying of other causes. Among those was heart disease. In the new paper, the researchers looked at four different populations of nearly 8,000 people who had their genomes sequenced. Even among younger people, those with the mutationscalled clonal hematopoiesis of indeterminate potential, or CHIPshowed a higher rate of heart disease.
We were fully expecting not to find anything here, says Kathiresan. But the odds of having an early heart attack are four-fold higher among younger people with CHIP mutations.
MORE: This New Kind of Stem Cell May Revolutionize How We Treat Diseases
Whats significant about the CHIP mutations are that they arent inherited. They are accumulated over time, from exposures to all sorts of things that can damage DNA. Among people over 70, 10% of people have these mutations, says Kathiresan. Whether they develop heart problems (or cancer) depends on how many of the mutated cells are circulating in the blood. The load of mutations increases over time," Kathiresan says. "The higher the load, the more the risk of heart disease.
Fortunately, there are ways to detect the mutated cells. Currently available blood tests for blood cancers can easily keep track of the volume of mutated cells, which means that monitoring the CHIP mutations could be a new way to identify people at higher risk of having heart problems, keep track of their risk and guide treatments.
When the researchers introduced the CHIP mutations into mice, they learned more about how a cancer-causing gene can contribute to heart disease. It appears that the CHIP mutations cause atherosclerotic plaques in the blood vessels, which contributes inflammation and hardening of the arteries that can trigger heart attacks.
There's still a lot to learn. As exciting as the findings are, its still too early to add CHIP testing to routine blood screening to identify people at higher risk of having heart problems. And because CHIP contributes to heart disease in a new way, its possible that the mechanisms to control CHIP-related heart events have nothing to do with cholesterol, exercise and blood pressure. The mouse work suggests that the path to heart disease is something different from what we have been working on so far, says Kathiresan.
More work needs to be done to determine if there are ways to counteract the effect of the mutation on plaques or control the rate at which the mutations build up in these cells. Currently there isnt a drug thats safe enough or efficacious enough to treat people with, says Ebert. But its a very active area of research to identify interventions that can decrease the size of the mutated cell population or potentially eliminate them.
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The Unexpected Way Genes Can Double Heart Disease Risk - TIME
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FDA moves to clear path for drugs aimed at cancer-causing genes – Lexington Herald Leader
Posted: at 4:45 am
NBCNews.com | FDA moves to clear path for drugs aimed at cancer-causing genes Lexington Herald Leader This represents some of the biggest opportunities in medicine to treat and cure debilitating and, yes, very costly diseases, Gottlieb wrote in remarks prepared for his appearance earlier this week before the Senate panel responsible for overseeing ... FDA Working to Lift Barriers to Generic Drug Competition |
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FDA moves to clear path for drugs aimed at cancer-causing genes - Lexington Herald Leader
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