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June 21, 2017 12:00 ET | Source: Center for the Advancement of Science in Space

Kennedy Space Center, FL, June 21, 2017 (GLOBE NEWSWIRE) -- The Center for the Advancement of Science in Space (CASIS) and the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH), today announced five grants have been awarded in response to afunding opportunityfocused on human physiology and disease onboard the International Space Station (ISS) U.S. National Laboratory. Data from this research which will feature tissue chips (or organs-on-chips) will help scientists develop and advance novel technologies to improve human health here on Earth. These initial five projects are part of a four-year collaboration through which NCATS will provide two-years of initial funding of approximately $6 million, to use tissue chip technology for translational research onboard the ISS National Laboratory. Awardees will be eligible for a subsequent two years of funding, pending availability of funds, based upon performance and achieving milestones for each project.

The opportunity to partner with CASIS to perform tissue chip science on the International Space Station is a remarkable opportunity to understand disease and improve human health, said NCATS Director Christopher P. Austin, M.D. Physiological functions in the microgravity of the International Space Station will provide insights that will increase translational effectiveness on earth, including identifying novel targets for drug discovery and development.

The NCATS grants will support the following research projects:

Lung Host Defense in Microgravity

George Worthen, M.D. and Dan Huh, M.D, Childrens Hospital of Philadelphia (PA)

Implementation Partners: Space Technology and Advanced Research Systems (STaARS) and SpacePharma Inc

There is a link between infections and the health of our immune system. Infections are commonly reported onboard spacecraft where exposure to microgravity negatively affects immune system function, but the mechanisms responsible are not well understood. The goals of this project are to test engineered microphysiological systems that model the airway and bone marrow; and to combine the models to emulate and understand the integrated immune responses of the human respiratory system in microgravity.

Organs-on-Chips as a Platform for Studying Effects of Microgravity on Human Physiology: Blood-Brain Barrier-Chip in Health and Disease

Christopher Hinojosa, M.S. and Katia Karalis, D.S., M.D, Emulate, Boston (MA)

Implementation Partner: SpaceTango

The objective of this project is to validate, optimize and further develop Emulates proprietary Organs-On-Chips technology platform for experimentation with human cells in space. The intent is to develop an automated platform and software to accelerate experimentation in space that will become available to the broader scientific community for studies in human physiology and disease in space. The scientific findings will provide new advancements for Earth studies in human disease and drug discovery. The Brain-Chip to be studied in microgravity is a prototype for an organ system centrally positioned in homeostasis and thus, involved in the pathogenesis of multiple types of disease including neurodegeneration, traumatic injury, and cancer.

Cartilage-Bone-Synovium Microphysiological System: Musculoskeletal Disease Biology in Space

Alan Grodzinsky, Sc.D., M.S and Murat Cirit, Ph.D., Massachusetts Institute of Technology, Cambridge (MA)

Implementation Partner: Techshot

This research focuses on a cartilage-bone-synovium joint tissue chip model to study the effects of space flight on musculoskeletal disease biology, motivated by post-traumatic osteoarthritis and bone loss. The effects of pharmacological agents to ameliorate bone and cartilage degeneration will be tested on earth and in the International Space Station, using a quantitative and high-content experimental and computational approach.

Microgravity as Model for Immunological Senescence and its Impact on Tissue Stem Cells and Regeneration

Sonja Schrepfer, M.D., Ph.D., Tobias Deuse, M.D., and Heath J. Mills, Ph.D., University of California, San Francisco (CA)

Implementation Partner: Space Technology Advanced Research Systems (STaARS)

Many space-related physiological changes resemble those observed during cellular aging, including defects in bone healing, loss of cardiovascular and neurological capacity, and altered immune function. This project aims to investigate the relationship between an individuals immune aging and healing outcomes, and to investigate the biology of aging from two directionsnot only during its development in microgravity conditions but also during recovery after return to earths environment.

Effects of Microgravity on the Structure and Function of Proximal and Distal Tubule Microphysiological System

Jonathan Himmelfarb, M.D., and Ed Kelly, M.S, Ph.D., University of Washington, Seattle (WA)

Implementation Partner: BioServe Space Technologies

When healthy, your two kidneys work together filter about 110 to 140 liters of blood to produce about 1 to 2 liters of urine every day. Dehydration or diseases like diabetes and high blood pressure impair kidney function and result in serious medical conditions including protein in the urine and kidney stones. Like osteoporosis, these conditions are even more common and follow an accelerated time-course in people living in microgravity. This project will send a kidney model to the International Space Station in order to understand how microgravity and other factors affect kidney function, and to use these discoveries to design better treatments for proteinuria, osteoporosis, and kidney stones on earth.

Our partnership with NCATS builds upon dramatic results fostered by public and private investment in organ-on-chip research and enables these pioneering researchers the opportunity to leverage the ISS National Laboratory to further advance an integral and burgeoning area of medical discovery to improve human health on Earth, said CASIS Deputy Chief Scientist Dr. Michael Roberts. Additionally, through these creative and collaborative partnerships with established granting agencies like the NCATS, the ISS National Lab demonstrates that research in microgravity is a viable setting to push beyond the terrestrial limits of scientific discovery and opportunity.

All grants and subsequent flight opportunities are contingent on final contract agreements between the award recipients, NCATS and CASIS.

For more information on the NCATS Tissue Chip for Drug Screening Program, including Tissue Chips in Space, please visit https://ncats.nih.gov/tissuechip.

To learn more about the on-orbit capabilities of the ISS National Lab, including past research initiatives and available facilities, visitwww.spacestationresearch.com.

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About CASIS: The Center for Advancement of Science in Space (CASIS) is the non-profit organization selected to manage the ISS National Laboratory with a focus on enabling a new era of space research to improve life onEarth. In this innovative role, CASIS promotes and brokers a diverse range of research inlife sciences,physical sciences,remote sensing,technology development,andeducation.

Since 2011, the ISS National Lab portfolio has included hundreds of novel research projects spanning multiple scientific disciplines, all with the intention of benefitting life on Earth. Working together with NASA, CASIS aims to advance the nations leadership in commercial space, pursue groundbreaking science not possible on Earth, and leverage the space station to inspire the next generation.

About the ISS National Laboratory:In 2005, Congress designated the U.S. portion of the International Space Station as the nation's newest national laboratory to maximize its use for improving life on Earth, promoting collaboration among diverse users, and advancing STEM education. This unique laboratory environment is available for use by other U.S. government agencies and by academic and private institutions, providing access to the permanent microgravity setting, vantage point in low Earth orbit, and varied environments of space.

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By Crystal Maynard U.S. Army Medical Research and Materiel Command

FORT DETRICK, Md., June 21, 2017 Scientists at the U.S. Army Center for Environmental Health Research here are hoping to determine how bones heal in microgravity, based on an experiment that launched to the International Space Station aboard SpaceX in February and returned to earth aboard SpaceX's Dragon cargo craft in March.

Through the Department of Defense Space Test Program, the USACEHR Integrative Systems Biology group and their partners at the Indiana University School of Medicine collaborated with NASA and the Center for the Advancement of Science in Space to have the scientists aboard the International Space Station conduct the experiment for a month.

The primary goal of this research project is to translate new discoveries in bone regeneration for osteoporosis, fracture healing and other bone disorders. Between 2002 and 2009, extremity injury accounted for up to 79 percent of reported trauma cases from combat theaters. Improvised explosive devices and high-energy explosions can cause extremity trauma so severe that often amputation is the only treatment.

Bone Healing

"We're trying to understand what happens in the body as the bones start healing," said Dr. Rasha Hammamieh, director of Integrative Systems Biology at the USACEHR and the study's lead scientist. "Understanding of bone healing is a mission critical subject for both the military and astronaut community."

The researchers carried out systems biology studies to understand the physiological events associated with wound healing mechanisms when subjected to gravitational forces and to identify potential signatures to predict the healing outcomes. USACEHR hopes that the results will provide a new understanding of the biological reasons behind healing mechanisms, as well as show the efficacy of the osteoinductive drugs at stressed conditions and their susceptibility to gravity.

According to Hammamieh, 40 mice were segregated into a specially-designed habitat under different treatment regimens for a month aboard the International Space Station. While in space, the mice were cared for and monitored by astronauts while the USACEHR and University of Indiana School of Medicine team monitored their progress daily via video. Following the completion of the testing, the mice were shipped back to Earth for comparison with a control group that remained on the ground.

Continued here:
Army Scientists Hope Space Experiment Unlocks Clues to Bone Healing - Department of Defense

Artists concept of a pulsar (blue-white disk in center) pulling in matter from a nearby star (red disk at upper right). The stellar material forms a disk around the pulsar (multicolored ring) before falling on to the surface at the magnetic poles. The pulsars intense magnetic field is represented by faint blue outlines surrounding the pulsar. Credit: NASA

A NASA instrument built to help astronomers learn about the structure and behavior of neutron stars, super-dense stellar skeletons left behind by massive explosions, has been mounted to an observation post outside the International Space Station after delivery aboard a SpaceX supply ship earlier this month.

Since its arrival inside the trunk of SpaceXs Dragon cargo capsule, the X-ray astronomy experiment has been transferred from the spacecrafts unpressurized carrier to a platform on the space-facing side of the space stations starboard truss backbone, powered up and checked to ensure it can point at stellar targets as the research outpost orbits around Earth.

The Neutron Star Interior Composition Explorer, or NICER, is now going through alignment checks and test scans, allowing scientists to fine-tune the instrument. The calibrations should be complete next month, and NICERs ground team has penciled in July 13 as the first day of the instruments 18-month science mission.

NICERs developers at NASAs Goddard Space Flight Center crammed 56 individual X-ray mirrors inside the instruments shell, with matching silicon detectors that will register individual photons of X-ray light, measuring their energies and times of arrival.

NASA says NICER is the first mission dedicated to neutron star research. Astronomers discovered neutron stars in 1967, decades after scientists first predicted their existence.

Neutron stars are left behind after lower-mass stars exploded in violent supernovas at the ends of their lives. The material from the star ends up crammed into an object the size of a city, and astronomers say one of the densest stable forms of matter in the universe resides in the deep interiors of neutron stars.

Scientists compare the density of a neutron star to packing the mass Mount Everest into a sugar cube. One teaspoon of neutron star matter would weight a billion tons on Earth, according to NASA.

NICER flew to the space station inside the rear trunk of a SpaceX Dragon supply ship, which launched June 3 from NASAs Kennedy Space Center in Florida and berthed with the orbiting outpost June 5.

The stations Canadian-built robotic arm extracted the NICER experiment from the Dragon spacecraft June 11, and the instrument rode to its mounting location on an external platform EXPRESS Logistics Carrier-2 on a mobile rail car down the stations truss.

Mission controllers in Houston commanded and monitored the multi-day transfer from the ground, with the help of the stations two-armed Dextre robot.

The space stations robotic arm installed NICER on its mounting plate June 13, and controllers powered up the instruments electronics the next day, verifying all systems were OK. Range of motion tests were completed Friday after engineers needed extra time to release troublesome launch restraint bolts.

NICER rode to the space station with two other experiments in Dragons trunk.

One of the payloads, sponsored by the Air Force Research Laboratory, will test a new solar array design could be used on future commercial satellites, making the power generators 20 percent lighter and able to fit into a launch package four times smaller than conventional fold-out solar panels.

A commercial Earth-imaging platform developed by Teledyne Brown was also stowed in Dragons trunk. TheMultiple User System for Earth Sensing, or MUSES, can host high-definition and hyperspectral cameras for Earth-viewing.

The MUSES payload was robotically moved to its new home on the space station before NICER, and the solar array testbed was unfurled for seven days of testing this week.

The installation of NICER clears the way for nearly a month of calibrations before it can start regular science observations.

Neutron stars are fantastical stars that are extraordinary in many ways, said Zaven Arzoumanian, NICERs deputy principal investigator and science lead at Goddard. They are the densest objects in the universe, they are the fastest-spinning objects known, they are the most strongly magnetic objects known.

The NICER science team wants to know the structure and composition of neutron stars, which are so extreme that normal atoms are pulverized, freeing subatomic particles like neutrons, protons and electrons.

As soon as you go below the surface of a neutron star, the pressures and densities rise extremely rapidly, and soon youre in an environment that you cant produce in any lab on Earth, said Slavko Bogdanov, a research scientist at Columbia University who leads the NICER light curve modeling group.

Unlike black holes, which develop from explosions of stars more than 20 times the mass of the sun, neutron stars can be directly observed.

A partnership between NASA, the Massachusetts Institute of Technology and the Naval Research Laboratory, NICER should give scientists their first measurements of the size of a neutron star.

They emit light all across the spectrum, from radio waves to visible light up to X-rays and gamma rays, primarily in narrow beams from their magnetic poles, Arzoumanian said. Just like the Earth, the magnetic poles on a neutron star are not necessarily aligned with the spin of the star, so you can get narrow beams that sweep as the star spins, just like a lighthouse.

And if we happen to be in the path of the sweep we see a flash everytime one of these beams go by and the stars from a distance appear to be pulsing, so theyre called pulsars, Arzoumanian said.

Scientists will also demonstrate the potential of using the timing of pulses from neutron stars for deep space navigation.

Were going to look at a subset of pulsars in the sky called millisecond pulsars, said Keith Gendreau, NICERs principal investigator at Goddard. In some of these millisecond pulsars, the pulses that we see are so regular that they remind us of atomic clocks.

Atomic clocks are the basis of the Global Positioning System satellites, according to Gendreau.

NASA calls the navigation demonstration the Station Explorer for X-ray Timing and Navigation Technology, or SEXTANT.

Jason Mitchell, SEXTANTs project manager at Goddard, said his team aims to use predictable pulsar signals to locate the space station with a precision of 6 miles, or 10 kilometers, without the aid of GPS satellites or on-board navigation solutions.

Thats a small step compared to GPS, but its a giant step for using only pulsar measurements, and that will help us get into deep space, Mitchell said.

Our goal is to turn the G in GPS into galactic, and make it a Galactic Positioning System, he said.

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Experiment devoted to neutron star research installed on space ... - Spaceflight Now