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Category Archives: Transhuman News
Genetic tests help identify relative risk of 25 cancer-associated mutations – Medical Xpress
Posted: June 28, 2017 at 5:47 am
June 27, 2017 Credit: CC0 Public Domain
No one wants to hear that they have a mutation in their DNA associated with the development of cancer. But it may be even more difficult to accept that, in many cases, clinicians can't say whether or by how much that mutation might increase a person's actual risk of developing the disease. This uncertainty causes anxiety and clouds treatment decisions.
Now, in the largest study of its kind, researchers at the Stanford University School of Medicine and Fox Chase Cancer Center in Philadelphia have analyzed the genetic test results, family histories and disease status of nearly 95,600 women who underwent genetic testing for 25 mutations associated with the development of breast and ovarian cancer. Some of the women had cancer; many did not. Seven percent of the women in the study carried at least one of the mutations, the researchers found.
The researchers hope the study is the first step to providing much-needed clarity to women and their physicians as they struggle to interpret the results of genetic testing. It may also help guideline-making organizations such as the American Cancer Society recommend when additional or more-frequent screening tests might be appropriate.
"The results of this study will help to personalize our risk estimates and recommendations for preventive care," said Allison Kurian, MD, associate professor of medicine and of health research and policy at Stanford. "A better understanding of cancer risks can help women and their clinicians make better-informed decision about options to manage cancer risk."
For example, Kurian said, some women with a high risk of developing breast cancer might consider preventive mastectomy, whereas those with lower riskfor example, a twofold elevation over the average riskmight instead pursue intensive regular screening, including breast magnetic resonance imaging.
Kurian is the lead author of the study, which will be published online June 27 in JCO Precision Oncology. Michael Hall, MD, associate professor of clinical genetics at the Fox Chase Cancer Center, is the senior author. The study was funded by Salt Lake City-based Myriad Genetics Inc., which performed the genetic testing.
What does a mutation mean?
Increasingly, women who are tested for a panel of cancer-associated mutations are given a mixed bag of results. Advances in DNA sequencing have made it quicker, easier and cheaper to identify mutations in an ever-growing panel of cancer-associated genes. With the exception of a few well-studied mutations such as BRCA1 and BRCA2, however, the exact effect of most of these remains murky because few large-scale studies have been completed.
The researchers assessed the mutation status of 95,561 women with and without the disease who chose to have their genome tested by Myriad Genetics for the presence of 25 cancer-associated mutations between September 2013 and September 2016. They matched the women according to their ages, ethnicity and family history of cancer to assign a relative risk of developing cancer to each of the mutations.
Kurian and her colleagues found that eight of the mutations were positively associated with the development of breast cancer, and 11 were positively associated with ovarian cancer. Increased cancer risk for women carrying the mutations ranged from two to 40 times that of a woman without the mutations.
'Significant advantage'
"This large sample size provided a reliable data set on real people," said Hall. "This is a significant advantage as we work to identify the strength of association between mutation and risk."
In many cases the researchers' findings dovetailed with what had already been surmised from smaller studies. But there were some surprises. One mutation assumed to increase a woman's risk of breast cancer was shown to instead increase the likelihood of ovarian cancer. Three other mutations thought to increase the risk of breast cancer seem instead to have little effect.
"One surprising finding was the association of an increased ovarian cancer risk with mutations in a gene called ATM," said Kurian. "Although this risk was relatively small numerically, it was statistically significant, and to our knowledge it had not previously been published. Additional studies will be important to determine the robustness and clinical relevance of this finding, and to expand the evidence base that we use to counsel our patients."
The work is an example of Stanford Medicine's focus on precision health, the goal of which is to anticipate and prevent disease in the healthy and precisely diagnose and treat disease in the ill.
Explore further: Findings suggest a gap between need, availability of genetic counseling
Physicians often fail to recommend genetic testing for breast cancer patients at high risk for mutations associated with ovarian and other cancers, according to a large study by researchers at the Stanford University School ...
A large scale study of women carrying faults in important cancer genes should enable doctors to provide better advice and counselling for treatments and lifestyle changes aimed at reducing this risk.
A recent survey of over 2,000 women newly diagnosed with breast cancer found that half of those who undergo bilateral mastectomy after genetic testing don't actually have mutations known to confer increased risk of additional ...
(HealthDay)Women need to be aware their risk for ovarian cancer increases with age. Half of all cases affect women age 63 or older, according to specialists at Fox Chase Cancer Center in Philadelphia.
In a study involving more than 31,000 women with cancer-causing mutations in the BRCA1 or BRCA2 genes, researchers at The Basser Center for BRCA, the Abramson Cancer Center, and the Perelman School of Medicine at the University ...
A massive global study led by researchers at the University of Melbourne and Cancer Council Victoria has confirmed that the risk of developing breast cancer from some relatively rare genetic changes is similar to that from ...
Patients with common widespread forms of cancer will enjoy longer life expectancy and reduced risk of recurrence thanks to a multimodal optical spectroscopy probe developed by Canadian researchers.
No one wants to hear that they have a mutation in their DNA associated with the development of cancer. But it may be even more difficult to accept that, in many cases, clinicians can't say whether or by how much that mutation ...
In a new study, published online in the July 26 issue of PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Xijing Hospital and Sun Yat-sen Cancer Center in China, report that DNA ...
With 20,000 diagnoses each year, ovarian cancer is the ninth most common cancer and fifth leading cause of cancer death among women in the United States. So many women die from ovarian cancer because it often goes undetected ...
Two challenges in treating patients with estrogen-positive breast cancer (ER+) have been an inability to predict who will respond to standard therapies and adverse events leading to therapy discontinuation. A study at The ...
Cancer tumours manipulate a natural cell process to promote their survival suggesting that controlling this mechanism could stop progress of the disease, according to new research led by the University of Oxford.
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Genetic tests help identify relative risk of 25 cancer-associated mutations - Medical Xpress
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Gene Mutation Linked to Retinitis Pigmentosa in Southwestern US Hispanic Families – Texas Medical Center (press release)
Posted: at 5:47 am
Thirty-six percent of Hispanic families in the U.S. with a common form of retinitis pigmentosa got the disease because they carry a mutation of the arrestin-1 gene, according to a new study from researchers at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health.
Retinitis pigmentosa is a group of rare, genetic eye disorders in which the retina of the eye slowly degenerates. The disease causes night blindness and progressive loss of peripheral vision, sometimes leading to complete blindness. According to Stephen P. Daiger, Ph.D., senior author of the study, an estimated 300,000 people in the U.S. suffer from the disease, which gets passed down through families.
In the study published recently in Investigative Ophthalmology & Visual Science, UTHealth researchers found that in a U.S. cohort of 300 families with retinitis pigmentosa, 3 percent exhibited a mutation of the arrestin-1 gene. However, more than 36 percent of Hispanic families from the cohort exhibited the arestin-1 mutation and they all came from areas in the Southwestern U.S., such as Texas, Arizona and Southern California.
When I started studying retinitis pigmentosa in 1985, we set out to find the one gene that causes the disease. Thirty-three years later, weve found that more than 70 genes are linked to retinitis pigmentosa, said Daiger, a professor in the Human Genetics Center and holder of the Thomas Stull Matney, Ph.D. Professorship in Environmental and Genetic Sciences at UTHealth School of Public Health.
Some of the genes that cause retinitis pigmentosa are recessive, which means two mutations are required, and some are dominant, which means you only need one mutation. Arrestin-1 piqued Daigers interest because that particular mutation is dominant while all previously found mutations in the gene are recessive. This unexpected finding shows that even a single mutation in the gene is sufficient to cause the disease.
Daiger and his team have identified the genetic cause of retinitis pigmentosa for 75 percent of families in their cohort. Possible treatments for some forms of retinitis pigmentosa are being tested but are still limited. However, the speed at which companies are developing gene therapies and small molecule therapies gives reason to hope, he said. Daiger and his collaborators have begun to connect some of the patients in the retinitis pigmentosa cohort to clinical trials that treat specific genes.
I want our cohort families to know that even if there is not an immediate cure for their specific gene mutation, at this rate it wont be long until a therapy becomes available, said Daiger, who also holds the Mary Farish Johnston Distinguished Chair in Ophthalmology at McGovern Medical School at UTHealth.
UTHealth coauthors include Lori S. Sullivan, Ph.D.; Sara J. Browne, Ph.D.; Elizabeth L. Cadena; Richard S. Ruiz, M.D., and Hope Northrup, M.D. Additional co-authors are from Nationwide Childrens Hospital; Kellogg Eye Center at the University of Michigan; Retina Foundation of the Southwest; Casey Eye Institute at Oregon Health and Science University; Vanderbilt University and the Department of Molecular and Human Genetics at Baylor College of Medicine.
Support for the study, titled A novel dominant mutation in SAG, the arrestin-1 gene, is a common cause of retinitis pigmentosa in Hispanic families in the Southwestern United States, was provided by the William Stamps Farish Fund and the Hermann Eye Fund.
Additional support was provided by the National Institutes of Health (EY007142, EY009076, EY011500, EY010572 and K08-EY026650), a Wynn-Gund TRAP Award, the Foundation Fighting Blindness, the Max and Minnie Voelker Foundation and a grant to the Casey Eye Institute from Research to Prevent Blindness.
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Gene Mutation Linked to Retinitis Pigmentosa in Southwestern US Hispanic Families - Texas Medical Center (press release)
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Pruning Spurious Genetic Links Clarifies Heritability in Sporadic ALS – Alzforum
Posted: at 5:47 am
27 Jun 2017
Scientists believe genetic variation accounts for much of the risk of sporadic amyotrophic lateral sclerosis (SALS). However, estimates on just how much heritability the known ALS genes confer range from 11 to 28 percent. In the June 21 Neurology, researchers led by Summer Gibson and Jonathan Downie at the University of Utah School of Medicine, Salt Lake City, describe how to better determine that number. Their method takes pathogenicity of rare variants into account. In a small cohort, they found that only 17 percent of SALS cases carried variations predicted to be harmful in the genes known to be associated with ALS to date. This percentage is lower than several previous estimates. However, Downie stressed that additional risk variants in other genes remain to bediscovered.
In an accompanying editorial, Peter Andersen at Ume University, Sweden, applauded the use of predictive algorithms to determine how likely a genetic variant is to be pathogenic. This approach is the real novelty of the present study, hewrote.
Studies of twins have pegged the overall heritability of SALS as high as 60 percent (see Al-Chalabi et al., 2010).However, three genome-wide association studies indicate the current set of ALS-linked genes explain just 21 percent of SALS, and other studies have come up with similar numbers (Jul 2014 news;Nov 2014 news;Renton et al., 2014).None of these studies attempted to weed out harmless variations that might inflate genetic risk estimates (Jul 2012 webinar).
To better determine the contribution of known ALS genes, the authors sequenced the whole exomes of 87 SALS patients of European ancestry who were being seen at the University of Utah. None of them had a family history of the disease. Downie and colleagues looked for repeat expansions in C9ORF72 and ATXN2, plus for rare coding variants among 31 other ALSgenes.
Altogether, they identified 28 variants in 25 patients. Five of the variants were C9ORF72 expansions, two were ATXN2 expansions, and two were pathogenic SOD1 alleles. The other 19 coding variants had not been previously linked toALS.
To determine if these 19 variations were harmful, the authors used a method called MetaSVM,which combines scores from several different pathogenicity prediction algorithms (Dong et al., 2015). The analysis concluded that only six of the19 would alter protein function. The upshot: 15 of the 87 participants, or 17.2 percent, likely had genes that contributed to their disease. Compared with a cohort of 324 healthy controls, the sporadic ALS patients were almost five times as likely to carry an ALS-linked variant predicted to be harmful, but had only a slightly higher chance of carrying any variant in an ALS-linked gene. The results demonstrate the importance of focusing on genetic associations predicted to be pathogenic, Downie toldAlzforum.
Because the harmful variants all occurred in genes linked to familial disease, it is possible these cases represent unrecognized familial ALS, Downie said. Familial disease can sometimes fly under the radar, either because only a single case shows up in small families, or because new mutations in the germline cause it. This study cannot determine whether the genetic variants it found caused disease or merely heightened risk for it, Downie noted. For example, the SOD1 mutation that turned up typically acts recessively, but neither of the two people affected carried two copies. It is unclear if the gene acted dominantly, predisposed the carriers to the influence of other genetic or environmental risk factors, or had no effect. At least one study has reported a dominant mode of action for the mutation (Al-Chalabi et al., 1998).
The findings also emphasize that the ALS genes known to date account for only a small portion of the predicted genetic risk in sporadic disease. Larger studies are needed to find the missing genes, Downie noted. Genetic studies involving thousands of ALS patients are ongoing, such as Project MinEin the Netherlands.Madolyn BowmanRogers
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Pruning Spurious Genetic Links Clarifies Heritability in Sporadic ALS - Alzforum
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Rampell: The play’s not the thing – The Ledger
Posted: at 5:47 am
Catherine Rampell The Washington Post
WASHINGTON -- The show must not go on.
So sayeth some of President Donald Trump's most ardent fans, who spent the past couple of weeks attempting to shut down a production of "Julius Caesar" with a Trump-like character in the title role.
These Trumpkins -- part of a bloc known for mocking political correctness, safe spaces and undue efforts to avoid offending the pwecious feewings of others -- deemed the show politically incorrect, unsafe and offensive.
Peaceful protest would be well within their rights. But these illiberal cultural illiterates instead wanted curtains for the offending Elizabethan play.
They stormed the stage at multiple shows, including the closing performance. They yelled and screamed inside and outside the open-air production -- part of the Public Theater's annual Shakespeare in the Park series -- to drown out dialogue they disliked. They threatened violence, sometimes quite graphically.
Some even sent death threats to other productions of Shakespeare and other plays in other parks.
The justification for these present-day disruptions and threats is that, at least according to (wrong) right-wing media reports, the production advocates assassination of a Trump-like Roman tyrant. But the only people lately threatening political violence in the name of "Julius Caesar" are those who wanted to shut this play down.
If these reactionaries had actually thought about the play, they'd realize its portrayal of the aftermath of assassination offers the opposite lesson: that "those who attempt to defend democracy by undemocratic means pay a terrible price and destroy the very thing they are fighting to save," as the Public put it in a statement to theatergoers.
There's a part of me that wants to rejoice that, 168 years after New York's Astor Place riots (also inspired by a contentious interpretation of the Bard), the theater can still be a source of so much controversy. In recent months not just "Julius Caesar" but also "Hamilton" has brought a raucous and artistically challenging rialto to the center of national social discourse.
Still, needless to say, death threats are not the type of intellectual engagement and social validation that most theater nerds were looking for.
The violent rhetoric of recent days is certainly no fault of the Public, even if, in choosing to portray Caesar with blondish hair, an ultra-long tie and a Slovenian-accented paramour, it clearly intended to provoke.
Nor is this debacle the fault of a few misguided protesters alone.
After all, they were just firing the latest salvo in the ongoing war against the free exchange of ideas, that most precious and endangered of liberal democratic values.
Plenty of conservatives like to believe that illiberalism is confined to liberal college students. Certainly there is evidence that millennials are at the vanguard of hostility to free speech. But as I have written time and again, attempts to stamp out speech are not confined to young or old, or left or right.
Instead, there is a growing sense on both sides of the aisle, and among all generations, that the free marketplace of ideas is broken. Everyone seems to believe that the inferior and dangerous ideas of their enemies are unfairly gaining ground; therefore, the words and beliefs of those enemies must be fair game for suppression.
And yes, attempts to shut down "Julius Caesar" -- like attempts to shut down conservative campus speakers -- are about objections to words and beliefs. They are not about protecting politicians or vulnerable minority groups from physical harm, despite the claims of would-be censors.
In "Julius Caesar," Shakespeare hinted that he expected his play to offer lessons for generations to come, though perhaps not the ones his characters believe they are offering.
"How many ages hence/Shall this our lofty scene be acted over/In states unborn and accents yet unknown!" declaims Cassius, after proudly smearing himself with the slain Caesar's blood.
Censors willing, let's hope Cassius' prediction continues to hold true.
Catherine Rampell (crampell@washpost.com) is a columnist for The Washington Post.
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The true story behind Netflix’s superb GLOW is just as wild as the show – Quartz
Posted: at 5:47 am
Netflix has produced yet another unexpected summertime hit, this time in the form of a delightfully bingeable series about female professional wrestlers in the 1980s. GLOW, released last week, is equal parts hilarious and pensive, matched only in wildness by the real-life all-female wrestling league on which its based.
In the show, Alison Brie plays a struggling actress who finds herself auditioning for the Gorgeous Ladies of Wrestling (G.L.O.W.), the brainchild of a sleazy Hollywood director and the young hotshot producer whos financing him. Many of the other women auditioning are also aspiring actresses, either hoping to use the gig as a stepping stone to bigger and better things or forced there because no one else would have them.
Liz Flahive and Carly Mensch, the creators of Netflixs GLOW, said they were first inspired to make the series after watching a 2012 documentary about the real G.L.O.W. Never expected to be a success, the league quickly became a hit in the United States, airing on millions of TVs across the country from 1986 to 1990.
Unlike most male wrestling at the time, G.L.O.W. was celebrated for being extremely politically incorrect (many of the villainous characters were meant to be of foreign origin) and unabashedly campy. Each wrestler had her own signature rap shed dish out before entering the ring. The shows budget was so small that creator David McClanes on-air office was literally a phone booth. One wrestler described it as vaudeville mixed with Saturday Night Live mixed with wrestling.
The women were separated into good and bad girls (wrestling fans know these categories as faces, or heroes, and heels, or villains) and lived together in a house not far from the Las Vegas casino where the show was filmed. They often acted in their personas even when the cameras were off. Many, like Emily Dole (better known as Mountain Fiji), became household names.
But almost as quickly as it came, the Gorgeous Ladies of Wrestling was gone. Meshulam Riklis, the magnate who financed the show, inexplicably decided to pull his funding, and in 1990 G.L.O.W. went off the air after four seasons. Continuations and revivals were attempted, but many of the performers had moved onto other things.
The documentary that inspired Flahive and Mensch is currently available on Netflix (and smartly advertised right next to the Netflix series). Its only about 75 minutes long and well worth watching for fans of Glowor anyone whos interested in a wild, stranger-than-fiction story of how an all-female wrestling league became a bona fide American phenomenon, if only for the briefest of moments.
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The true story behind Netflix's superb GLOW is just as wild as the show - Quartz
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‘Get Out or We Will Kill You’: Jewish Students Allege Censorship and Harassment in Campus Lawsuit – Reason (blog)
Posted: at 5:46 am
YouTubeIn a federal lawsuit filed last week, a group of Jewish plaintiffs allege that San Francisco State University has systematically turned a blind eye toand in some instances actively facilitatedcensorship and harassment of Jewish students and speakers on the public university's campus. The lawsuit points, in particular, to the 2016 disruption of a speech by Jerusalem Mayor Nir Barkat, numerous incidents of anti-Jewish and anti-Israel speech on campus, as well as an incident in which the Jewish student organization Hillel was allegedly banned from a student fair.
Opinions about the lawsuit fall along predictable dividing lines. The editorial board of J., the Jewish News of Northern California, praised the suit and argued that the protesters at the Nir Barkat event had "trampled the free speech rights of Jewish students." On the other hand, Dima Khalidi of Palestine Legal called the Barkat protest "political speech that is protected by the First Amendment" and said that "the complaint is going to fail."
Both sides have a point. The lawsuit raises real concerns about the treatment of Jewish students at SFSU. But the plaintiffs seem to want it both ways: Even as the suit contends that SFSU is violating the free speech rights of Jewish students, it also demands that the university censor protected speech by Palestinian students and their allies, citing anti-Jewish harassment.
As Justice Thurgood Marshall wrote, "the freedom to speak and freedom to hear are inseparable; they are two sides of the same coin." If, as the lawsuit alleges, SFSU officials told campus police to "stand down" while anti-Israel protesters disrupted Nir Barkat's speech, the university may indeed have violated students' First Amendment rights to invite and hear a speaker of their choosing.
Video footage of Barkat's attempt to speak at SFSU last year shows protesters engaging in loud, sustained chanting while students attending the speech huddle around a seated Barkat in an attempt to hear him. While protest is indeed protected by the First Amendment (as is a normal level of "booing" and brief interruptions from the audience), the right to protest does not extend to the right to be so vocally disruptive, for such a prolonged period of time, that the speaker cannot be heard.
And if, as the suit alleges, the university allowed the Hillel student group to be excluded from tabling at a university-sponsored fair because of the organization's viewpoint, that too could constitute a First Amendment violation at a public university like SFSU.
Moving from the First Amendment to the harassment claims, some of the speech cited by the plaintiffs may have crossed the line from protected speech into unprotected threats, such as counter-protesters allegedly yelling "get out or we will kill you" at Jewish students participating in a Hillel-sponsored peace rally.
Other parts of the lawsuit, however, point to examples of clearly protected speech and expression as grounds for the claim that a "hostile environment" exists for Jewish students on campus. In alleging that the university has been deliberately indifferent to a racially hostile environment, the plaintiffs point to examples of constitutionally protected political expression such as posters featuring a picture of a dead baby with the caption "Made in IsraelPalestinian Children Meat, Slaughtered According to Jewish Rites Under American License," as well as students holding placards proclaiming "my heroes have always killed colonizers" and "resistance is not terrorism" alongside portraits of Leila Khaled, the first female airplane hijacker. It is not difficult to see why such speech would offend many students, but asking a government institution like SFSU to police this kind of political rhetoric in the name of preventing a "hostile environment" is a prescription for both First Amendment violations and political side-choosing.
In short: it's complicated. If the truth of the allegations is proven in court, the plaintiffs have some very real grievances about some of the university's conduct and, certainly, about what J. refers to as the "selective outrage" when it comes to the university's response to Jewish students on campus versus other students who claim to feel silenced or threatened. But in other ways, the suit goes too far, citing constitutionally protected political speech and expression as examples of harassment.
This fight should never have had to go to court in the first place. A university campus should be a place where people who disagree about important issues can discuss their differences openly, not a place where opposing views are shouted down, threats are tossed across protest lines, and both sides work to suppress the speech of their opponents.
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'Get Out or We Will Kill You': Jewish Students Allege Censorship and Harassment in Campus Lawsuit - Reason (blog)
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Advertisers protest as military TV sets separate censorship – Bangkok Post
Posted: at 5:46 am
Channel 7's logo on display at a digital fair. BBTV's Channel 7 and Channel 5 have set up their own censorship association, disgruntling the Advertising Association of Thailand. (Photo by Jiraporn Kuhakan)
The Advertising Association of Thailand (AAT) has asked BBTV's Channel 7 and Channel 5 to explain why they have established their own censorship association, given the waste of time and money that such a group would represent.
Having two standards of censorship presents additional expense and procedural hurdles for advertising agencies and brands and will also affect the ad industry as a whole, said AAT president On-Usa Lamliengpol.
She said the creation of a new censorship association led by Channel 7, Channel 5 and some digital TV operators, and without any obvious explanation, would result in a double standard for the ad industry.
Royal Thai Army Radio and Television Channel 5 is owned and operated by the army. Channel 7 officially is owned by Bangkok Broadcasting Television. It was originally acquired by the army in 1967.
"We urge these channels to explain this move clearly and as soon as possible," Ms On-Usa said, adding that otherwise it will lead to complications for the ad industry.
The AAT has been operating for more than 23 years. The association is a non-profit coordinator between ad agencies and digital TV operators and allows the industry to run smoothly, Ms On-Usa said.
The Radio and Television Broadcasting Professional Federation and the Association of Digital Television Broadcasting also voiced displeasure with the establishment of the second standard. The entities pushing for the second standard must stop or at least provide clarification, they said.
Ms On-Usa said the censorship procedure will run as usual on the AAT's side, but brands and agencies must know that they will run into trouble if their TV spots are assessed by both associations.
"Ad agencies need to help the AAT clarify the issue for their own sake," she said.
AAT vice-president Niwat Wongprompreeda said that while he does not know Channel 7's and Channel 5's intentions, he knows that having another censorship commission will complicate matters.
Agencies and brands will struggle with the rising costs of TV ad production, Mr Niwat said, since they still need to broadcast on Channel 7 -- the most influential channel in the country. He said Channel 7 receives 30-40% of total TV ad expenditure.
The censorship process normally has no cost. It takes one day to know if a TV spot is rejected or not; if it is, it must be modified and presented again to the association for approval.
Palakorn Somsuwan, assistant managing director for programming and advertising at Bangkok Broadcasting & TV Co, the operator of Channel 7, said the new censorship association will uplift censorship standards and benefit TV operators by creating stronger networks.
On the other hand, Col Natee Sukonrat, vice-chairman of the National Broadcasting and Telecommunications Commission (NBTC), said media regulations are sensitive and whether the self-censorship measure established by the private sector will help the NBTC to regulate the media industry will need to be looked into in close detail.
"The NBTC supports the latest establishment of a censorship association, as it will help create stronger measures for broadcasting suitable ads in the future," Col Natee said.
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Libertarianism – Simple English Wikipedia, the free …
Posted: at 5:45 am
This page is about free-market individualism. Some people (especially in Europe and Latin America) use the word libertarianism to refer to "libertarian socialism" (see anarchism)
Libertarianism is an idea in ethics and politics. The word comes from the word "liberty". Simply put, libertarians believe that people should be able to do whatever they desire as long as their actions do not harm others. As a result, Libertarians want to limit the government's power so people can have as much freedom as possible.
Libertarianism grew out of liberalism as a movement in the 1800s. Many of the beliefs of libertarianism are similar to the beliefs in classical liberalism. It also has roots in anarchism and the Austrian School of economics.
Like other people, libertarians oppose slavery, rape, theft, murder, and all other examples of initiated violence.
Libertarians believe that no person can justly own or control the body of another person, what they call "self-ownership" or "individual sovereignty." In simple words, every person has a right to control her or his own body.
In the 19th century, United States libertarians like William Lloyd Garrison, Frederick Douglass, and Lysander Spooner were all abolitionists. Abolitionists were people who wanted to end slavery right away.
Garrison based his opposition to slavery on the idea of self-ownership. Since you have a natural right to control your own body, no one else has any right to steal that control from you. Garrison and Douglass both called slave masters "man stealers."
If you have a right to control your own body, then no one has a right to start violence (or force) against you.
Some libertarians believe that all violence is unjust. These libertarians are often called "anarcho-pacifists". Robert LeFevre was a libertarian who rejected all violence. However, most libertarians believe that there are some ways violence can be justified.
One thing that justifies violence is self defense. If someone is violent towards you, you have a right to defend yourself with equal force.
The libertarian Murray N. Rothbard said that it would be wrong to kill someone for stealing a pack of gum. If you steal gum, this is an act of violence against the property owner. The owner has a right to use defensive violence to get the gum back, but killing the thief goes too far. That is too much force because it is not equal to the force used by the thief. Punishment must be equal to the crime. A student and colleague of his, Walter Block, said that a punishment shouldn't be equal to the crime, but rather enough to make up for the damage the crime caused plus how much it cost to catch the criminal.
Some libertarians believe that it is your moral duty to defend yourself and your property if you can. This belief is usually held by Objectivists. These people believe that pacifism is immoral. Most libertarians reject this view.
All libertarians believe that it is wrong to start violence against any person or against what he or she owns. They call this the "non-aggression principle."
Ownership is the right to control something. Property is the thing that you control.
Libertarians believe that property rights come from self-ownership. This means that because you have a right to control your own body, you also have a right to control what you make with it.
The English philosopher John Locke said that a person comes to own something by using it. So, if you turn an area that no-one else owns into a farm and use it, that area becomes your property. This is called the "homestead principle."
Libertarians also say that you can become a legitimate owner by receiving something as a gift or by trading it with someone for something they own. You do not become a legitimate owner by stealing. You also do not become a legitimate owner by simply saying you own something. If you have not "homesteaded" the thing or received it through trade or gift, you do not own it.
Libertarians are opposed to states (or governments) creating any "laws" that tell people what they can and cannot do with their own bodies. The only legitimate laws are laws that say a person may not start violence against other people or their legitimate property. All "laws" stopping people from doing nonviolent things should be repealed, according to libertarians. (These "laws" are usually called "victimless crimes" because there is no victim if there is no theft.)
In most countries, the state (or government) takes tax money from the people. All libertarians support cutting taxes back, and some libertarians believe the state should not take tax money at all. Libertarians think people can take care of the poor without the government. They believe that people should pay for the things that they want to use, but not have to pay for other things that they do not want. Tax evasion (refusal to pay taxes to the state) is a victimless crime. Libertarians would prefer to see taxation replaced with lotteries, user fees, and endowments.
Libertarians think everyone should be allowed to decide what is good or bad for her/his own body. Libertarians think if people want to drive cars without wearing seat belts, it is their own choice. They should not be forcibly stopped from doing that, not even by the state. If a person wants to donate all of her/his money to a charity, or waste it all gambling, that is also something she/he should decide for herself/himself. No one should be forcibly stopped from doing that, not even by the state. Libertarians even say that if adults want to use harmful drugs, they should be allowed to do that, even if it spoils their lives. It is the drug user's own choice because it is the drug user's own body. As long as the drug user does not start using violence against other people or their legitimate property, no one should use violence against the drug user or the drug user's legitimate property, not even the government.
Many libertarians also believe that families and friends should look after people so that they will not use drugs, drive without seat belts, or do other things that are dangerous for them. But no one can force others to do things that they do not want to do, or to stop them from doing nonviolent things that they want to do.
There are two basic types of libertarians. All libertarians fall into one of these two broad types.
Minarchists are libertarians who believe that society should have a state with very limited power. They typically believe that the only things the state should have are police and judges to make sure that people obey the laws. Some also believe in having a military to make sure that no one attacks the country. Some minarchists believe in having a small amount of taxation.
Two famous minarchist libertarians are Robert Nozick and Ayn Rand. Nozick believed that the only legitimate thing a state can do is have a police force. He called his legitimate state a "night-watchman state." Rand believed that the state should have a police force and a court system.
Libertarian anarchists usually call themselves anarcho-capitalists, free-market anarchists, individualist anarchists, or just anarchists.
Libertarian anarchists do not believe the state is needed. They believe that people can organise their own lives and businesses. They want to replace the state with voluntary organisations, including charities, private companies, voluntary unions, and mutual aid societies. They also want to end all forced taxation.
They say that state police can be replaced with "DROs" (Dispute Resolution Organisations) or "private protection agencies." They also say that state judges can be replaced with "private arbitration."
The most famous libertarian anarchist was Murray N. Rothbard. Others include Lysander Spooner, Benjamin R. Tucker, and Linda & Morris Tannehill.
Most libertarians fall under one of the two types of libertarians listed above. But there are other types, too.
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Response to 10 Ways Not to Make Your Friends Libertarian – Being Libertarian
Posted: at 5:45 am
Its easy for an individual that has been cringeworthy himself on many occasions even on a national stage (also, it seems you may be lacking some self-awareness with that egotistical prick comment, Mr. Ive Read 100 Books On This Ideology) to separate himself from any of the blame when it comes to how cringeworthy some libertarians are.
Aside from that, Charles Peralos assertion that libertarians are [] the cringe lords of Facebook stood out to me as a poor generalization. For example, in a world where regressive leftists showcase their poor understanding of economics, their abysmal critical thinking skills, and their hatred of the freedom of speech on social media (ironic, right?), its simply absurd to say that libertarians are the worst. All sides of the political spectrum have their cringeworthy members; libertarians arent unique in that regard.
In my opinion, Charless points were undoubtedly sloppy and this is not just because his articles are typically a poor read, both structurally and contextually. His article proves that he simply had an ax to grind, and instead of coming up with 10 compelling reasons not to make your friends libertarian, he just compiled a list of things he doesnt like about some libertarians.
So, heres a different list of 10 ways not to make your friends libertarian.
In America, liberals may have stolen the term for our political ideology, but that doesnt mean we are what they are; this is why I refer to leftists as such rather than liberals, and also because most leftists arent liberal they dont believe in things like the freedom of speech like they used to.
I dont want to focus too much on Charles and look like I myself have an ax to grind, since this isnt the time or place, but his content proves exactly my point on this particular issue.
Wanting to save social security, attack possible opportunities for secession, partner with a radical and violent leftist group like Black Lives Matter, support government paying off student loan debt rather than simply repudiating said debt, and advocate for universal healthcare are all ideas that swing left to varying degrees.
Moving away from the author at hand, there are plenty of other people that have done the same, from Gary Johnsons I agree with Bernie 73% of the time comments, to other liberty advocates pushing leftist ideals.
Lets stop making libertarianism about leftism. Theyre not compatible. As long as universal healthcare, universal basic income, and maintaining social security and the rest of the welfare state are on the table, libertarianism loses.
Part of the problem I have with the liberty movement these days is that many people have abandoned principle over party in favor of party over principle.
Sure, political strategy often simply revolves around winning. But attacking the wrong people is the worst idea for an up-and-coming party. I see libertarians within the Libertarian Party attacking Rand Paul, Ron Paul, Justin Amash, and Thomas Massie simply for being Republicans, without realizing that most of us would vote for these people if they were on our ticket in a heartbeat.
These people may be Republicans, but theyre an ally to liberty and libertarianism. Lets not forget that the Libertarian Party isnt the only mechanism for advancing liberty.
I could write an entire book revolved around the idea that libertarians shouldnt hate veterans just because they also hate that the government funds the military through taxation.
Whether or not you think our country should have such an expansive nanny state as it does, or whether you think the country should exist at all, military people havent done anything to you.
Attacking these people, who likely will be the easiest to pitch libertarianism, is a poor choice to make. These people have seen the disastrous effects of interventionist foreign policy, these people have seen why an expansive military doesnt need to exist.
These people also are just people, and theyre not baby killers. Theyre ordinary people, and most of them are reservists who never see combat deployment. Generalizing all the people who have served our country as killers, savages, and awful humans who want to steal your tax money to fund failed wars is not only an awfully poor and incorrect generalization, but also not a way to expand the libertarian base.
Anarcho-capitalists are the purists of the libertarian ideology. This one should go without saying: attacking the most devoted liberty minds doesnt do libertarianism any good. Theyre an important part of the ideology, and whether or not you agree with them, they have a lot of good things to say, if youll just listen.
If youre worried about the public image of libertarianism, and believe that people will generalize libertarianism as anarchism or anarcho-capitalism, then simply make it your mission to explain how thats not the case when youre pitching someone.
Life, liberty, and property; its clich, I know.
But that, in short, is libertarianism. The right to life, absolute liberty, and property, so long as you dont harm anyone else. The Johnson campaign was guilty of this, as well as many other libertarians. Property rights are integral to what libertarianism is as an ideology; if we abandon this integral plank, our ideology will fail.
We cant make our friends into libertarians if we dont have a philosophy. We also cant do it if we dont have a solid philosophy to pitch. Property rights are important, lets not forget that.
The abortion debate has always been murky when it comes to libertarianism, with both sides debating which provides more liberty. I tend to fall on the pro-life side, except when rape results in pregnancy since there was no consent and it is essentially self-defense by the mother. I stand firm that life begins at the first heartbeat, which is around six weeks. The debate, in my opinion, should be whether life begins at conception or not. I havent personally heard an argument that convinced me life begins at conception.
Whether we even need to have this debate anymore has recently been taken into question, but since we will for the foreseeable future, it makes its way onto this list.
Pro-life libertarians see the unborn life as exactly what it is a life. They argue that the mother and father had consensual sexual intercourse whilst understanding the possible consequences, and that the termination of said pregnancy is murder because it is the taking of a life; just because the life resides in a womans womb doesnt make it her property, rather she consented to the possibility of pregnancy by taking an action thats meant to begin a pregnancy.
Whether or not you agree with this, pro-life libertarians make good points. Not only can they attract a sizable right-wing electorate that tends to agree with libertarians otherwise, but these pro-life libertarians themselves are key to our cause.
Disagreements on abortion arent worth dividing the house over.
Some people cant get out and be real-world activists for liberty, and thats understandable they work full-time jobs that fill their days, have children, and so on. Not everyone can dedicate time out of their lives to get out and fight for liberty.
I had to turn down the chance to fly across the country and participate in a grassroots activism campaign this summer because I have to work my day job in order to save enough money before I transfer to an out-of-state college in the fall. I dedicate my time to being the news editor here at Being Libertarian, writing opinion pieces when I can, and using social media to spread the ideology. Once I have the ability to be a real-world activist, I will, but we shouldnt punish people who cant get out and be activists. Theyre doing what they can just because its not the medium you prefer doesnt make it bad or ineffective.
Even if someone has the time but doesnt want to be a real-world activist doesnt mean theyre not contributing by posting to social media. If you couldnt tell, social media is alive and well, and its an apt place to be a liberty advocate.
The only way to achieve everything in one fell swoop whether it be minarchism or anarcho-capitalism is to have some sort of civil war or revolutionary war. Thats a pretty drastic situation, and not one thats popular, for obvious reasons.
Anything other than that takes time. Even secession takes time; at least all 50 states would have to secede, and theres absolutely no way that happens all in one shot. Secessionism is one of the quickest ways to get what we want, assuming secession doesnt result in another powerful government, with the only change being territorial size.
Besides those two, we have to realize that as much as we may want it to not everything is going to happen all at once. We cant get everything we want right away, so we should push for every victory we can achieve.
By participating and contributing to a gradual move towards libertarian ideals, we allow our ideas to have exposure on a grander stage.
Its a win-win scenario we shrink government gradually (while not shutting ourselves off to other options to accelerate said shrinkage), and we give libertarianism more exposure.
To be honest, I think its pretty ridiculous that I have to even make this point.
Antifa are not anti-fascist, they are fascist. They are against free-speech and the freedom of association, and use violence to suppress speech and ideas. Libertarians, especially those within the party, have supported or sympathized with these people. Whether its to spite President Trump, or its based on pure ignorance, libertarians that side with Antifa are siding against everything they believe in.
Just because these people are anarchists (actually, theyre anarcho-communists), doesnt mean we should side with them. If anything, thats just going to reinforce the publics growing notion that these people are libertarians and anarcho-capitalists, which is absolutely not the case.
This final, most important point takes a direct shot at Charless point that we shouldnt remind people that taxation is theft, or discuss the non-aggression principle (NAP).
These are both key principles, like property rights, that make libertarianism what it is.
Sure, if all you ever say is taxation is theft, youre going to push people to click that ever-so-enticing unfollow button. However, we shouldnt just throw these slogans to the curb.
Make America Great Again and America First were key slogans that captured the attention of an otherwise silent and forgotten demographic. They were clich on the surface, and were great for a bumper sticker. But everyone knew what these things meant: they were essentially shorthand for some of the policies Trump advocated for. If we want to pitch our ideas to people, we can do the same with our slogans. As long as we dont say taxation is theft without expanding upon why its an issue and why we should fix it, these are things we can utilize to expand the libertarian base.
We dont advocate libertarianism for fun, we advocate it because we want to free ourselves from coercion, and seek the most amount of liberty attainable. Remember, we can win this fight. Liberty can win, and it will, as long as we dont forget our mission.
This post was written by Nicholas Amato.
The views expressed here belong to the author and do not necessarily reflect our views and opinions.
Nicholas Amato is the News Editor at Being Libertarian. Hes an undergraduate student at San Jose State University, majoring in political science and minoring in journalism.
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Response to 10 Ways Not to Make Your Friends Libertarian - Being Libertarian
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Seven ‘ideal’ goals to maintain healthy heart – Gulf Times – Gulf Times
Posted: at 5:45 am
By Will Boggs MD/Reuters Health
Meeting some or all of the American Heart Associations seven ideal cardiovascular health goals is associated with longer life and fewer heart attacks and strokes, no matter your age. In fact, in a recent group of elderly patients, the benefit of an ideal cardiovascular health in reducing mortality and vascular events was comparable to what is observed in younger populations, Dr Bamba Gaye from University Paris Descartes in France told Reuters Health by e-mail. This is a very good news, which suggests that it is never too late to prevent the development of risk factors for cardiovascular disease (CVD). Gaye and colleagues analysed whether achieving some or all of the American Heart Association (AHA) seven ideal goals Lifes Simple 7 would affect peoples risk of dying or having a stroke or heart attack during a specific study period. The seven goals include: -Keep body mass index (BMI) a ratio of weight to height lower than the overweight cutoff; -Never start smoking, or have stopped at least 12 months ago; -For at least 75 minutes a week, perform vigorous activity, or perform moderate physical activity at least 150 minutes a week; -Follow a healthy diet that includes vegetables and fresh fruit daily, fish twice or more a week, and less than 450 calories a week from sugar; -Keep blood pressure below 120/80 without medication; -Maintain a normal cholesterol level without medication; -Maintain a normal blood sugar without medication. Out of the 7,371 study participants, whose average age was 74, only one individual had met all seven goals. Only 5% of participants met at least five goals, researchers reported in the Journal of the American College of Cardiology. For all goals except physical activity and total cholesterol, women were more likely than men to be at ideal levels. The research team tracked the study subjects to monitor their health; half of the participants were tracked more than nine years. Compared to people who meet no more than two of the goals, in those who met three or four the risk of death during the study was reduced by 16%, and meeting five to seven goals cut the risk by 29%. In fact, the risk of death fell by 10% for each additional goal at the ideal level. Similarly, the risk of coronary heart disease and stroke fell by 22% for each additional goal at the ideal level. The ideal goal would be to have no risk factors for cardiovascular disease at all, Gaye said. However, our study also shows a graded benefit on outcome according to the number of risk factors at the optimal level. Hence, a perhaps more realistic approach would be to advise older subjects to have at least one risk factor at an optimal level, and to progressively gain more risk factors at optimal level. We would like emphasise that (good) health in general and cardiovascular health in particular is the cornerstone of (good) life and we all need to take care of it over the life course, Gaye concluded. The good news is that it is never too late to optimise our own health in elderhood. The goal of successful ageing is not immortality, but limiting time spent with illness and disability, writes Dr Karen P Alexander from Duke University School of Medicine, Durham, North Carolina in an editorial published with the study.
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Seven 'ideal' goals to maintain healthy heart - Gulf Times - Gulf Times
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