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Category Archives: Transhuman News

Study Led By Israeli Scientist Discovers Wild Wheat Genome Sequencing – Breaking Israel News

Posted: July 10, 2017 at 7:46 pm

So she kept fast by the maidens of Boaz to glean unto the end of barley harvest and of wheat harvest; and she dwelt with her mother-in-law. Ruth 2:23 (The Israel Bible)

Wild emmer wheat spike (Photo: Raz Avni)

A global team of researchers has published the first-ever Wild Emmer wheat genome sequence inSciencemagazine (Wild emmer genome architecture and diversity elucidate wheat evolution and domestication).

Wild Emmer wheat is the original form of nearly all the domesticated wheat in the world, including durum (pasta) and bread wheat. Wild emmer is too low-yielding to be of use to farmers today, but it contains many attractive characteristics that are being used by plant breeders to improve wheat.

The study was led by Dr. Assaf Distelfeld of Tel Aviv Universitys School of Plant Sciences and Food Security and Institute for Cereal Crops Improvement, in collaboration with several dozen scientists from institutions around the world and an Israel-based company, NRGene, which developed the bioinformatics technology that accelerated the research.

This research is a synergistic partnership among public and private entities, said Dr. Daniel Chamovitz, Dean of TAUs George S. Wise Faculty of Life Sciences, who was also involved in the research. Ultimately, this research will have a significant impact on global food security.

Our ability to generate the Wild Emmer wheat genome sequence so rapidly is a huge step forward in genomic research, said Dr. Curtis Pozniak from the University of Saskatchewan, a project team member and Chair of the Canadian Ministry of Agriculture Strategic Research Program. Wheat accounts for almost 20% of the calories humans consume worldwide, so a strong focus on improving the yield and quality of wheat is essential for our future food supply.

From a biological and historical viewpoint, we have created a time tunnel we can use to examine wheat from before the origins of agriculture, said Dr. Distelfeld. Our comparison to modern wheat has enabled us to identify the precise genes that allowed domestication the transition from wheat grown in the wild to modern day varieties. While the seeds of wild wheat readily fall off the plant and scatter, a change in two genes meant that in domesticated wheat, the seeds remained attached to the stalk; it is this trait that enabled humans to harvest wheat.

This new resource allowed us to identify a number of other genes controlling main traits that were selected by early humans during wheat domestication and that served as foundation for developing modern wheat cultivars, said Dr. Eduard Akhunov of Kansas State University. These genes provide invaluable resource for empowering future breeding efforts. Wild Emmer is known as a source of novel variation that can help to improve the nutritional quality of grain as well as tolerance to diseases and water-limiting conditions.

New genomic tools are already being implemented to identify novel genes for wheat production improvement under changing environment, explains Dr. Zvi Peleg of the Hebrew University of Jerusalem, Israel. While many modern wheat cultivars are susceptible to water stress, Wild Emmer has undergone a long evolutionary history under the drought-prone Mediterranean climate. Thus, utilization of the wild genes in wheat breeding program promote producing more yield for less water.

The wheat genome is much more complex than most of the other crops and has a genome three times the size of a human genome. said Dr. Gil Ronen, NRGenes CEO. Still, the computational technology we developed has allowed us to quickly assemble the very large and complex genome found in Wild Emmers 14 chromosomes, to a standard never achieved before in genomic studies.

For the first time, the sequences of the 14 chromosomes of wild emmer wheat are collapsed into a refined order, thanks to additional technology that utilizes DNA and protein links. It was originally tested in humans and recently demonstrated in barley, both of which have smaller genomes than Wild Emmer wheat. says Dr. Nils Stein, the Head of Genomics of Genetic Resources at Leibniz Institute of Plant Genetics and Crop Plant Research in Germany. These innovative technologies have changed the game in assembling the large cereal genomes,

This sequencing approach used for Wild Emmer wheat is unprecedented and has paved the way to sequence durum wheat (the domesticated form of Wild Emmer). Now we can better understand how humanity transformed this wild plant into a modern, high-yielding durum wheat, said Dr. Luigi Cattivelli, coauthor of the work and coordinator of the International Durum Wheat Genome Sequencing Consortium.

We now have the tools to study crops directly and to make and apply our discoveries more efficiently than ever before, concluded Dr. Distelfeld.

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Researchers Reconstruct Genome of Wild Wheat – Sci-News.com

Posted: at 7:46 pm

An international research team led by Tel Aviv University scientist Dr. Assaf Distelfeld has reconstructed the genome of the wild wheat Triticum turgidum, the original form of nearly all the domesticated wheat in the world.

Triticum turgidum. Image credit: Stan Shebs / CC BY-SA 3.0.

Wheat is one of the founder crops that likely drove the Neolithic transition to agrarian societies in the Fertile Crescent more than 10,000 years ago.

Its domestication caused a shift in traits, which mostly relate to seed dormancy, spike morphology, and grain development.

For example, while the spikes of wild wheat shatter at maturity, all domesticated wheat spikes remain intact, which enables easier harvest.

From a biological and historical viewpoint, we have created a time tunnel we can use to examine wheat from before the origins of agriculture, Dr. Distelfeld said.

To reconstruct the 14 chromosomes of Triticum turgidum, Dr. Distelfeld and co-authors used 3D genetic sequencing data and software.

The wheat genome is much more complex than most of the other crops and has a genome three times the size of a human genome, said co-author Dr. Gil Ronen, CEO of NRGene Ltd, Israel.

Still, the computational technology we developed has allowed us to quickly assemble the very large and complex genome found in wild wheats 14 chromosomes, to a standard never achieved before in genomic studies.

Our ability to generate the wild wheat genome sequence so rapidly is a huge step forward in genomic research, added co-author Dr. Curtis Pozniak, from the University of Saskatchewan.

Wheat accounts for almost 20% of the calories humans consume worldwide, so a strong focus on improving the yield and quality of wheat is essential for our future food supply.

In order to understand genetic changes underlying the evolutionary transition to a non-shattering state, the researchers compared genes responsible for shattering in domesticated wheat to the corresponding genes in wild wheat.

They identified two clusters of genes in domesticated wheat that have lost their function.

When they engineered strains of wheat with one of these gene clusters restored, the wheat exhibited unique spikes where the upper part was brittle and the lower part was not brittle.

These results suggest that the two gene clusters play a part in the transforming the brittle qualities of wild wheat.

Our comparison to modern wheat has enabled us to identify the precise genes that allowed domestication the transition from wheat grown in the wild to modern day varieties, Dr. Distelfeld said.

While the seeds of wild wheat readily fall off the plant and scatter, a change in two genes meant that in domesticated wheat, the seeds remained attached to the stalk; it is this trait that enabled humans to harvest wheat.

This research is a synergistic partnership among public and private entities, said co-author Dr. Daniel Chamovitz, of Tel Aviv University.

Ultimately, this research will have a significant impact on global food security.

The research is published in the journal Science.

_____

Raz Avni et al. 2017. Wild emmer genome architecture and diversity elucidate wheat evolution and domestication. Science 357 (6346): 93-97; doi: 10.1126/science.aan0032

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Generation Genome – sequencing is future for NHS, says report – BioNews

Posted: at 7:46 pm

The latest annual report of the Chief Medical Officer for England has recommended that personalised medicine approaches be adopted widely within the UK's NHS (National Health Service).

'Genomic medicine has huge implications for the understanding and treatment of rare diseases, cancer and infections,' says Professor Dame Sally Davies' report 'Generation Genome'. Patients should also benefit from speedier diagnosis and receiving the best available treatment.

It is hoped that the cost of sequencing, which continues to fall, will be offset by avoiding the wasted treatments and appointments caused by the current trial-and-error approach. The cost could be further reduced by concentrating the current 'cottage industry' of sequencing and interpreting genomes into a few specialist centres.

Around two-thirds of cancers currently have what are known as 'actionable genes', which allow a range of outcomes to be predicted with much greater accuracy than was previously possible. The number of these genes, and the number of cancers known to have them, are likely to rise as research progresses.

Actionable genes can indicate whether a patient is likely to suffer severe side effects from some treatments, whether a given treatment is likely to be effective, or even how likely a patient's cancer is to recur. These factors, if known, can help clinicians recommend the best treatment options for a given patient.

Sir Harpal Kumar, chief executive of Cancer Research UK, welcomed the report saying that it 'showcases just how much is now possible in genomics research and care within the NHS'. He told UK newspaper the Telegraph: 'Further understanding and application of genomics will be essential to successfully tackling cancer and saving many more lives from this devastating disease.'

Genome sequencing could also help diagnose individuals with rare diseases, many of which present in children and have a genetic basis. These can often take years to diagnose, and patients may end up seeing multiple specialists before receiving a diagnosis (see BioNews 903).

There are some concerns about data security, however. The NHS track record for IT includes a cyber attack in May this year, and a National Program for IT which consumed over 11 billion between 2002 and 2011 before it was eventually scrapped.

'This technology has the potential to change medicine forever but we need all NHS staff, patients and the public to recognise and embrace its huge potential,' said Professor Davies.

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First Human Head Transplant Operation Planned This Fall Using Frankenstein-Inspired Technique – Medical Daily

Posted: at 7:46 pm

In a recent interview with Business Insider, Italian neurosurgeon Sergio Canavero explained his ambitious plans to conduct the worlds very first human head transplant. Canavero claims the operation will take place in China this fall, and although the procedurehas clear medical uses for the paralyzed and other conditions, Canaveros ultimateplan is to explore life after death, and extend human longevity.

The project is known as head anastomosis venture, or HEAVEN for short, and involves placing the head of a living person onto the body of a brain- dead donor, Business Insider reported. Canavero and his team plan to conduct the operation in China this fall;thedonor isa brain-dead patient, and the head is froman undisclosed Chinese patient.

Read: Head Transplants Only 2 Years Away, Surgeon Claims; Operation Hopes To Treat Brain Diseases

Canavero will cut out the injured segments of the spinal cord in theparalyzed patient, and then replace the removed portion with spinal cord from a donor. The two spinal cords will be fused together using polyethylene glycol (PEG). As inspired byMary Shelley's classic "Frankenstein", Canavero plans to use electricity as the final component of the procedureto help coax the fibers from donor and donee to merge together and regrow at an accelerated speed.

While Canavero says that it would make sense to use this procedure to help more paralyzed patients, his ultimategoal isto extend human life.

"Im into life extension," he told Business Insider. "Life extension and breaching the wall between life and death."

Canavero explains that hesees his procedurehelping humans live longer than ever, as they can simply transplant their heads onto the body of a clone once they begin to age. In addition, Canavero hopes the procedure will help him create a real full death experience, allowing him to finally understand what happens once we pass away.

"I'm not religious but I don't believe consciousness can be created in the brain. The brain is a filter," Canavero told Business Insider, explaining what he really hoped to achieve from the experience.

Canaveros operation is highly controversial, with many critics citing that not only is it unethical, but also that it will not work. For example, Dr. James FitzgGerald, a consulting neurosurgeon at the University of Oxford, told Business Insider that, although Canavero may be correct in suspecting that electricity can coax fibers to merge, he still doesnt believe that his plan to use it to fuse a head to a body will work.

"I simply don't think the reports of joining spinal cords together are credible," said FitzGerald.

Spinal cords are extremely delicate parts of the body, and at the moment there have been no credible reports of them being correctly re-fused once broken. If this were possible, paralysis would no longer be a permanent condition, The Guardian reported. Still, Canavero is hopeful that by cutting the spinal cord with an incredibly sharp knife, and keeping the patient in a medically induced coma after the reconnection to minimize them moving, will help his operation become a success.

See Also:

First Human Head Transplant On The Horizon, Says Italian Scientist Sergio Canavero; Technology Easy To Administer And Has A Strong Safety Record

Chinese Plan Head Transplant For Paralyzed Patients, But Will Ethical Concerns Put It On Hold?

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The Microbial Mystery Behind Eczema – Huffington Post Canada

Posted: at 7:46 pm

With the summer heat, many Canadians no doubt will be replacing those long pants, shirts, and sweaters with shorts, tees, and swimwear. However, for up to one-sixth of our population, this choice may not come as easy as we think. It's because they suffer from a disease known officially as atopic dermatitis although most of us call it eczema.

Eczema is a difficult disease to pin down. The symptoms range from itchy rashes to cracked, oozing skin. This condition can be a mere annoyance but in severe cases, it can impact one's ability to function in society. The same difficulties can be said for treatment. Some can manage the condition with hygiene while others may require prescription medications.

When it comes to the cause, eczema has proven to be an enigma. Researchers have known for years the ailment arises due to a change in one's immunity. For some reason, the body tends to overreact in certain areas of the body leading to the symptoms. This explanation is the basis for numerous pharmacological treatments known to calm the immune response and reduce or eliminate the ailment.

While therapeutic options may be helpful for those suffering, for public health officials, there is a need to know why eczema happens. They need to understand how this alteration of immunity starts in the first place. If they can figure out why our defense forces go awry, they can develop steps to prevent the problem.

The most obvious potential culprits behind this disease are microbes. They can be found all over the skin and research has revealed different parts of the body have different microbial populations. One or more species could find themselves in areas where they don't belong, such as the elbows or the back of the knees, and in an infection-like process, force the immune system to alter in a manner that leads to symptoms.

This idea does seem sound and evidence has been shown to support this theory. Yet it has never been proven. The closest researchers have come is the identification of reduced microbial diversity in flare sites. However, no one has singled out one species.

Now that has changed thanks to a group of American researchers. They have devoted their attention to the microbes found in eczema. In the process, they have revealed the name of the most likely culprit. Unfortunately, the research also has led to even more questions.

The team collected microbial samples from children suffering from varying degrees of eczema. They also collected control samples from times when the kids were not suffering from flares. The hope was to find some distinct change in the types of microbes present and pinpoint one species as being the cause.

When these initial results came back, there was reason for hope. As seen in other studies, flares led to a reduce diversity of bacteria in the area. A closer examination revealed one particular species, Staphylococcus aureus, tended to be higher during symptoms. Moreover, more of this species meant worsening symptoms.

Right off the bat, this discovery makes perfect sense. The species is known to be involved in many skin conditions, including acne, impetigo, and rashes. But this result cannot explain why some individuals end up with eczema while others have no issues.

The answer comes in a subcategory of a species, known as strains. S. aureus has numerous different strains and each one acts differently from the rest. In this light, one or more strains might be responsible for causing the disease.

Not surprisingly, this is the direction the researchers went next. The team examined the diversity of the strains in the hopes of finding an appropriate culprit. As expected, they found blooms of single strains in the eczema areas. The path to an answer became a little clearer.

But the elation didn't last long. When the group compared these single strains among the different eczema patients, they found something rather unsettling. Each patient had a different troublesome strain.

This significantly increased the complexity of the situation and required the group to take the investigation to a new level. They needed to find out if these strains were producing a common molecule that led to symptoms.

The team explored the genetic information of the bacteria in the hopes of finding a common cause for the symptoms. They came across many potential candidate molecules yet none were expressed in all the strains. Rather than being able to hone in on a particular gene, the team realized the onset of symptoms was more complicated than they believed.

While the results of the study did not manage to find the smoking gun, the group did develop some useful information for public health officials. The onset of eczema is due to a lack of microbial diversity on the skin and S. aureus is the most likely candidate for trouble. Moreover, seeing blooms of a particular strain could spell trouble.

The discovery may lead to the development of new diagnostic measures to determine the risk for flares. This also may develop a new treatment concept in which the immune system is not targeted but the bacteria population. By increasing diversity through the addition of friendly microbes, eczema may be both prevented and treated.

If this direction pans out, the future of eczema prevention may come in a cream consisting of a diverse microbial population. All one would have to do is use it regularly when trouble arises. That way, they might be able to lose the worry about symptoms and confidently enjoy wearing those summer clothes.

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My Eczema Was Under ControlUntil I Got Pregnant – Health.com

Posted: at 7:46 pm

People say that pregnancy is supposed to be a happy time. Well, Im pretty sure those people don'thave eczema. For mea woman with a severe case of the skin condition, which causes itchy, red rashes on the skinthose nine months were the most miserable days of my life.

Up until I got pregnant at age 17, my eczema was manageable. I was diagnosed when I was four years old, and used the same topical steroid for years. Whenever I had a flare, I put on the cream and my skin would calm down. When I was eight, I moved to Tampa, Florida, and, despite the occasional rash, I still wore shorts and tank tops. Besides, the air felt good on my skin. But by the time I entered middle school, things started to get worse. The patches were spreadingto my wrists, the back of my legs, and eventually to my face. Then I got pregnant, and my skin just went crazy.

RELATED: 5 Things You Should Never Say to Someone With Eczema

I was two months pregnant when the left side of my face started to itch uncontrollably. I felt it before I went to bed one night, and by the next morning, my skin was so inflamed that my mom had to take me to the hospital. As the weeks went on, my skin got worse: I scratched the sores on my head so much so that my hair was falling out in patches, and my legs were raw from clawing at the skin.

As my due date neared, my mom took me to the hospital because she suspected that something was seriously wrong with me. Walking was too painful, and my legs were oozing so much that I had to keep them wrappedin bed sheets. When I was wheeled into the hospital on a chair, the doctors looked at me and basically shrugged. They didnt want to admit me because they didnt think there wasnt anything wrong. Luckily, my mom stood her ground, and someone took my blood pressure. Thats when I found out that I had preeclampsia, or very high blood pressure (which can lead to premature birth).

While monitoring my blood pressure, the doctors took culture swabs of my legs. Two days later, the results came back: MRSA, a serious, sometimes life-threatening infection caused by a type of Staph bacteria. Before I knew it, I was being whisked away to a room at the end of the hallan isolation room, where they told me I was going to be quarantined.

When my mom arrived back at the hospital, the doctors told her that shed need to wear a gown and gloves if she wanted to see me. She refused. She said, I lived with her while she had this infection. Im not talking to my daughter like that.

Two days after that, I was induced. The doctors moved me to a delivery room and gave me an epidural. I was only in labor for about threehours before giving birth: a healthy baby boy who weighed about 6.8 pounds. Hes ten years old nowand thankfully, he doesn'thave eczema.

RELATED: The Best Lotions for Eczema, According to Dermatologists

I was discharged a day and a half later, but I was still in a lot of pain, especially in my legs. Everything hurt. It even hurt to wash my sons bottle. I eventually had to go to a different hospital to get a prednisone shot. That was the first time in two months that my legs stopped hurting.

It wasanother three years before I found a good dermatologist. He did everything he could for me, even saw me on days when he had a full schedule. Now,I dont itch as much, and Im not in so much pain. My skin is regaining some of its color, and my eyebrows and eyelashes are starting to grow back; in the past, Id rubbed them off. For the first time in years, I feel as if Ive finally found help.

Jillian M., 27, from Tampa, Florida, as told to Maria Masters

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Clomid baby aspirin – How long does it take for clomid to start working – Van Wert independent

Posted: at 7:45 pm

VW independent/submitted information

DELPHOS A Delphos couple were injured in a home invasion assault that occurred Saturday morning.

David and Dianna Allemeier of 209 S. Pierce St. in Delphos were both taken to St. Ritas Medical Center in Lima for treatment of injuries received when a man gained entry to their home and reportedly assaulted them.

Delphos Police were first called out at 6:05 a.m. Saturday on a report of a suspicious person in the 300 block of Jackson Street who was knocking on doors and then walking away. However, while en route to that call, officers were informed that a man had been injured and was bleeding in the 200 block of Pierce Street.

When officers arrived on the scene, they found Allemeier bleeding from an injury to his neck. The Delphos resident said he received the injury from a man who had gained entry into his home.

Officers approached the residence and found the back door unlocked and a lot of blood at the scene. The home was secured and a K-9 and Crime Scene Unit sought from the Allen County Sheriffs Office.

Allemeier then said his wife was still in the house and officers then entered and found Mrs. Allemeier, who was also injured, in the bedroom area of the residence.

After the Allemeiers were transported to the hospital, a K-9 search was made of the area, and the house was processed by an Allen County sheriffs deputy.

No information was released on whether items were taken from the Allemeier house.

Police are currently seeking a young, skinny white male with black hair, possibly wearing cutoff shorts. Anyone with information is asked to contact the Delphos Police Department or Allen County Sheriffs Office.

The investigation is continuing, with no further information forthcoming at this time.

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Far More People Than Thought Are Carrying Rare Genetic Diseases – ExtremeTech

Posted: at 7:45 pm

Outside of evolutionary biology, the human body is often spoken of as a miracle of engineering. But those more familiar with its workings point out evolution is no perfectionist, often favoring clunky ad hoc solutions over thosemore elegant in design. In fact, the comparison of evolution to a gambler might be the most apt, and nowhere is this more evident than in reference to genetic diseases like hemophilia. Now a recent study published in the Annals of Internal Medicine suggests far more people than previously thought are carrying variants of rare genetic diseases and could force us to redefine what is considered a healthy genome.

Genetic disorders are those resulting from mutations in ones DNA, often with horrendous results. Previously, scientists believedgenetic disorders were present in only a small fraction of the human population, 5 percent or less. After all, a population riven with genetic mistakes would quickly die out, or so went the logic. However, the present study puts the fraction of people with mutations linked to genetic diseases at something closer to 20 percent.

But is nature really so clumsy as to allow a veritable swarm of deleterious mutations to slip through her quality control mechanisms? It turns out many genetic disorders hide secret advantages. Take a person with the mutation that causes sickle cell anemia. A single copy of the mutation for sickle cellanemiaactually protects against the disease malaria. Its only if someone receivestwo copies of the defective gene that the problematic form of sickle cellanemia results. With many genetic disorders, nature seems to be hedging her bets, allowing some defects to slip through if they can provide a survival advantage to the population at large.

Counterintuitively, an individual suffering from a rare genetic disease may represent a successful population-level response to a given environment. This dance between genes and environments is at the heart of what we think of as health. But for most of history, medicine has considered the well being of an individual in isolation from population-level genetics. A more nuanced understanding of rare genetic diseases would take into account the various benefits genetic mistakes confer. This also suggests a cautious approach when editing our own genomes with tools like tools like CRISPR. Even seemingly terrible mutations we would be tempted to eliminate from the genetic pool may confer some secret advantage geneticists have yet to discover.

The study comes at a time when routine genetic testing is the subject of a far-ranging debate. Many doctors fear the release of genetic data to patients would cause undue anxiety. This study didnt support those claims, and goes a distance to undermine the paternalistic style of medicine currently practiced in many developed nations. In the United States, for instance, doctors remain a crucial chokepoint through which patients must pass through to access genetictesting. That said, anumber of direct-to-consumer genetic testing companies like 23andMe are breaking down these barriers, and a host of websites and even smartphone apps exist to help one make sense of their genetic data.

Now read: What is gene therapy?

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China develops ‘genetic editing’ technology to clone puppies – and it could be used to breed super dogs – Mirror.co.uk

Posted: at 7:45 pm

Scientists i China have developed advanced genetic editing technology to successfully clone a beagle puppy.

Little Long Long, is China's first ever self-bred cloned dog, and is thought to be only the second in the world.

The beagle was created with double the amount of muscle mass as a normal dog of the same species, by 'deleting' a gene called myostatin.

Lai Liangxue, researcher at Guangzhou institute of biological medicine and health, told Science and Technology Daily : "This is a breakthrough, marking China as only the second country in the world to independently master dog-somatic clone technology, after South Korea."

Lai suggested that the cloning technology could be used to breed 'super dogs' which are better at hunting or running, to help police officers.

But some have criticised the process as being unethical after researchers said in the Journal of Molecular Cell Biology that they intended to create dogs with DNA mutations, including some that mimic human diseases, like Parkinson's.

Lai added: "The goal of the research is to explore an approach to the generation of the new disease dog models for biomedical research.

"Dogs are very close to humans in terms of metabolic, physiological and anatomical characteristics."

It has long been thought that dogs were one of the most difficult animals to clone, with only South Korea having achieved a successful 'copy' in the past.

For Lai's team in China, 65 embryos were 'edited and 27 pups were born, but one, Long Long, was born without the myostatin gene, therefore displaying increased muscle mass compared to that of her litter mates.

Guo Longpeng, the China press officer for the Asia division of People for the Ethical Treatment of Animals, told Sixth Tone: "Cloning is unethical.

"Like any other laboratory animal, these animals are caged and manipulated in order to provide a lucrative bottom line."

There's also a worry that the dogs could be bred as 'novelty' pets, allowing certain scientific or research teams to capitalise on owners who desire their dog to be a certain size, or of higher intelligence.

Lai and his team of 28 colleagues have said they have no plans to breed the muscular beagles as pets.

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Cards Against Humanity Might Be Releasing A Disney-Themed Pack – Konbini US

Posted: at 7:44 pm

Known as the most politically incorrect game there ever was,Cards Against Humanityis rumoredto delve even further into its appallingly hilarious dark and crude humor by creatinga Disney-themed pack.

(via giphy)

Following the success of the Harry Potter-inspired pack, Cards Against Muggles, these Disney inspired cards really could be the next best drinking game. The news was first circulated by Pretty52 after Cards Against Humanity themselves allegedly posted a picture of the first 18 cards on Facebook.

While the post was soon taken down, what goes online in the first placecan travel the world in seconds and indeed a hardcore fan managed to take a screenshot before the picture was deleted.

The new Disney inspired banter includes cheeky answers involving "vaginal burns from Lumiere," "Quasimodo's private time with his bells" and this might make you cry "Bambi's dead mother."

While it is still unsure whether this pack will actually become a reality considering the post has since been deleted, we are hoping we will be pleasantly surprised with its release.

Kiss your childhood innocence goodbye and get ready for a bundle of laughs it's time to witness Disney like you've never seen it before.

Read More ->These Postcards Let You Stay Close To Old Friends Without The Hassle Of Talking To Them

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