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Category Archives: Transhuman News

Gene that gets people hooked on cocaine has been identified and some are more at risk than others – Mirror.co.uk

Posted: July 11, 2017 at 9:45 pm

The gene that gets people hooked on cocaine has been found - and certain people could be more at risk than others.

Those who have an altered form of a the protein could be at higher risk of addiction, according to scientists.

The gene controls levels of the brain chemical glutamate which has been found to play a key role in drug dependence.

Rats with a mutated form of the protein, called mGluR2, produced more of the neurotransmitter - which eliminated cocaine's 'rewards'.

This is what keeps addicts wanting more opening the door to the gene could be 'packing a double punch.'

The researchers said it could act as a biomarker for screening those at risk of cocaine addiction - and as a therapeutic target for drug development.

Dr Zheng-Xiong Xi, of the US's National Institute on Drug Abuse, said: "Our work suggests that, if you could take a medicine to activate mGluR2 activity, then it would decrease or significantly inhibit both cocaine-taking and cocaine-seeking behaviours."

The study published in Cell Reports found rats that can't control glutamate were more likely to kick the habit once addicted.

This suggests the gene, which protects nerve cells from being destroyed by excess glutamate, is involved in modulating the reward-seeking behaviour associated with drug addiction.

The rats were more likely to consume cocaine when it was made freely available but less likely to seek it when they had to make more effort to obtain it.

When cocaine was no longer available, the rats were quicker to cease the behaviours that had previously resulted in the drug's delivery.

Even when cocaine was subsequently re introduced, they showed reduced interest for drug seeking, constituting a lower rate of relapse.

Dr Xi said: "The gene-knockout mice don't enjoy much reward when they take the cocaine. So when the drug is available to them, the animals work to increase their intake to feel rewarded.

"But when the drug is difficult to get, the reward isn't worth it anymore, the animal just wants to quit."

Low or absent mGluR2 expression caused the rodents to experience a lessened neurological reward when taking cocaine.

At the cellular level, the research illuminates the role that glutamate - the most abundant neurotransmitter in all vertebrates and a prominent contributor to pathways of learning, memory, and anxiety in humans - plays in cocaine addiction.

This goes beyond previous findings that focused on dopamine response, the 'feelgood' chemical more commonly associated with reward seeking, as the main culprit.

Deleting mGluR2 causes nerve cells to be awash in glutamate before any cocaine is ingested.

Cocaine "works" by binding to receptors in place of neurotransmitters like glutamate and dopamine, forcing them to float around and excite neuron junctions, or synapses.

So the pre-existing flood of glutamate limits its power to deliver a neurological reward.

The researchers also plan on studying the influence of mGluR2 - which has been preliminarily associated with alcohol and nicotine addictions - in relation to opiates such as heroin.

Added Dr Xi: "It seems that mGluR2 may be a common target for treating addictions to many drugs."

The finding adds to evidence glutamate, a neurotransmitter central to learning and memory, is also central to addiction.

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Gene that gets people hooked on cocaine has been identified and some are more at risk than others - Mirror.co.uk

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Controversial Gum Disease Risk Test Highlights Precision Medicine Marketing, Regulatory Issues – GenomeWeb

Posted: at 9:45 pm

NEW YORK (GenomeWeb) Interleukin Genetics' decision to stop selling a genetic test it claims can assess the risk of gum disease is welcome news for some experts in the field of dentistry who have long had serious concerns about the science underlying the product.

They contend that the test should have never come to market in the first place, but remained available to patients far too long because the leadership at Interleukin had influence within the dental research community, a group that is not well-enough versed in genetics to be able to parse the available data themselves.

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First gene therapy ‘a true living drug’ on the cusp of FDA approval – Washington Post

Posted: at 9:45 pm

PHILADELPHIA When doctors saw the report on Bill Ludwigs bone-marrow biopsy, they thought it was a mistake and ordered the test repeated. But the results came back the same: His lethal leukemia had been wiped out by an experimental treatment never before used in humans.

We were hoping for a little improvement, remembered the 72-year-old retired New Jersey corrections officer, who had battled the disease for a decade. He and his oncologist both broke down when she delivered the good news in 2010. Nobody was hoping for zero cancer.

The pioneering therapy administered to Ludwig and a few other adults at the University of Pennsylvania hospital paved the way for clinical trials with children. Six-year-old Emily Whitehead, who was near death, became the first pediatric recipient in 2012. Like Ludwig, she remains cancer-free.

Such results are why the treatment is on track to become the first gene therapy approved by the Food and Drug Administration. An FDA advisory committee will decide Wednesday whether to recommend approval of the approach, which uses patients own genetically altered immune cells to fight blood cancers.

If the panel gives the nod, the agency probably will follow suit by the end of September. That would open the latest chapter in immunotherapy a true living drug, said Penn scientist Carl June, who led its development.

The CAR T-cell treatment, manufactured by the drug company Novartis, initially would be available only for the small number of children and young adults whose leukemia does not respond to standard care. Those patients typically have a grim prognosis, but in the pivotal trial testing the therapy in almost a dozen countries, 83percent of patients went into remission. A year later, two-thirds remained so.

And childhood leukemia is just the start for a field that has attracted intense interest in academia and industry. Kite Pharma of Santa Monica, Calif., has applied for FDA approval to treat aggressive non-Hodgkins lymphoma, and a similar Novartis application is close behind. Researchers also are exploring CAR T-cell therapys use for multiple myeloma and chronic lymphocytic leukemia, the disease that afflicted Ludwig. They are also tackling a far more difficult challenge using the therapy for solid tumors in the lungs or brain, for example.

The excitement among doctors and researchers is palpable. Were saving patients who three or four years ago we were at our wits end trying to keep alive, said Stephen Schuster, the Penn oncologist who is leading a Novartis lymphoma study. That study and a Kite trial have shown that the treatment can put about one-third of adults with advanced disease those who have exhausted all options into remission.

Yet along with the enthusiasm come pressing questions about safety, cost and the complexity of the procedure.

It involves extracting white blood cells called T cells the foot soldiers of the immune system from a patients blood, freezing them and sending them to Novartiss sprawling manufacturing plant in Morris Plains, N.J. There, a crippled HIV fragment is used to genetically modify the T cells so they can find and attack the cancer. The cells then are refrozen and sent back to be infused into the patient.

Once inside the persons body, the T-cell army multiplies astronomically.

Novartis has not disclosed the price for its therapy, but analysts are predicting $300,000 to $600,000 for a one-time infusion. Brad Loncar, whose investment fund focuses on companies that develop immunotherapy treatments, hopes the cost does not prompt a backlash. CAR-T is not the EpiPen, he said. This is truly pushing the envelope and at the cutting edge of science.

The biggest concerns, however, center on safety. The revved-up immune system becomes a potent cancer-fighting agent but also a dangerous threat to the patient. Serious side effects abound, raising concerns about broad use.

Treating patients safely is the heart of the rollout, said Stephan Grupp of Childrens Hospital of Philadelphia, who as director of the hospitals cancer immunotherapy program led early pediatric studies as well as Novartiss global trial. The efficacy takes care of itself, but safety takes a lot of attention.

One of the most common side effects is called cytokine release syndrome, which causes high fever and flulike symptoms that in some cases can be so dangerous that the patient ends up in intensive care. The other major worry is neurotoxicity, which can result in temporary confusion or potentially fatal brain swelling. Juno Therapeutics, a biotech firm in Seattle, shut down one of its CAR T-cell programs after five patients died of brain swelling. Novartis has not seen brain swelling in its trials, company officials said.

To try to ensure patient safety, Novartis is not planning a typical product rollout, with a drug pushed as widely and aggressively as possible. The company instead will designate 30to 35 medical centers to administer the treatment. Many of them took part in the clinical trial, and all have gotten extensive training by Grupp and others.

Grupp said he and his staff learned about the side effects of CAR T-cell therapy and what to do about them through terrifying experiences that began five years ago with Emily Whitehead.

The young girl, who had relapsed twice on conventional treatments for acute lymphoblastic leukemia, was in grave condition. Grupp suggested to her parents that she be the first child to get the experimental therapy.

I said, Surely, this has been tried on kids somewhere else in the world, recalled her father, Thomas Whitehead of Philipsburg, Pa. But Steve said, Nope, some adults got it, but that was a different kind of leukemia.

After she received the therapy, Emilys fever soared, her blood pressure plummeted, and she ended up in a coma and on a ventilator for two weeks in the hospitals intensive care unit. Convinced his patient would not survive another day, a frantic Grupp got rushed lab results that suggested a surge of the protein Interleukin 6 was causing her immune system to relentlessly hammer her body. Doctors decided to give Emily an immunosuppressant drug called tocilizumab.

She was dramatically better within hours. She woke up the next day, her seventh birthday. Tests showed her cancer was gone.

The approval of CAR T-cell therapy would represent the second big immunotherapy advance in less than a decade. In 2011, the FDA cleared the first agent in a new class of drugs called checkpoint inhibitors. It has approved five more since then.

There are big differences between the two approaches. The checkpoint inhibitors are targeted at solid tumors, such as advanced melanoma and lung and bladder cancer, while CAR T-cell therapy has been aimed at blood disorders. And although checkpoint inhibitors are off the shelf, with every patient getting the same drug, CAR T-cell therapy is customized to an individual. Many immunotherapy experts think the greatest progress against cancer will be achieved when researchers figure out how to combine the approaches.

For the Penn team, the CAR T-cell story goes back decades, starting at the then-National Naval Medical Center in Bethesda, Md., where June and a postdoctorate fellow named Bruce Levine worked on new HIV treatments. In the process, they figured out a way to turbocharge T cells to make them more powerful and plentiful.

The pair moved to Philadelphia in 1999 and dove into cancer research. Two years later, Junes wife died of ovarian cancer, something he has credited as spurring him to work even harder in the field. In the years that followed, researchers across the country, including at the Memorial Sloan Kettering Cancer Center in New York and Fred Hutchinson Cancer Research Center in Seattle, racked up an array of tantalizing discoveries involving T cells.

Fast-forward to 2010, when Ludwig, who lives in Bridgeton, N.J., became Penns first patient to receive CAR T-cell therapy. Two other men got the treatment not long after. One is still in remission; the other relapsed and died.

But after those three patients, the Penn researchers ran out of money for more treatments. To try to raise interest and funding, they decided to publish the results of their work. The article that appeared in the New England Journal of Medicine in August 2011 created a firestorm, June said one that brought them new resources. David Porter, a Penn oncologist working with June, was on vacation in western Maryland and had to stop at a Kohls to buy a dress shirt for the immediate TV interviews.

The pediatric trial opened the following spring with Emily. Six months later, Penn licensed its technology to Novartis in exchange for financial support, which included a new on-campus cell-manufacturing facility.

With FDA approval seeming imminent, the researchers who were so instrumental in the therapys development and testing are almost giddy. Grupp is especially pleased that the advance will be available first to children. Usually everything is developed first for adults, he noted recently, and children are an afterthought.

Read more:

This is not the end: Using immunotherapy and a genetic glitch to give cancer patients hope

This 8-year-old is free of cancer for now after a breakthrough treatment

For a 6-year-old with cancer, a future staked on medicines hottest field

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First gene therapy 'a true living drug' on the cusp of FDA approval - Washington Post

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What the #$@! Democrats are swearing more. Here’s why – PBS NewsHour

Posted: at 9:44 pm

Democratic National Committee Chairman Tom Perez at a rally outside the White House on May 10, 2017. Perez has sworn frequently in public speeches since taking over the DNC earlier this year. Photo by REUTERS/Jonathan Ernst

Last month, Sen. Kirsten Gillibrand, D-N.Y., bluntly summed up the Democratic Partys goals under President Donald Trump.

If were not helping people, Gillibrand told an audience at a New York University forum, we should go the f**k home.

Earlier this year, newly-elected Democratic National Committee Chairman Tom Perez didnt mince words when assessing the White House budget proposal. Its a s**tty budget, Perez said in a speech in Maine, part of a cross-country tour that included several expletive-laced speeches.

In the aftermath of Mr. Trumps victory in the 2016 election, a growing number of Democrats have begun cursing in public, using language that in the past was reserved for private conversations away from voters and the media.

The trend isnt entirely unprecedented, of course. In 2010, then-Vice President Joe Biden famously let an expletive slip during the White House signing ceremony for the Affordable Care Act. But the rise in examples of public cursing from Gillibrand, Perez, Sen. Kamala Harris, D-Calif., and other Democrats marks a sharp departure from the usual language used by politicians on the left in recent decades.

The shift seems to be a reaction, at least in part, to Trumps crass tone as a candidate, and may have paved the way for a new age of political incorrectness. Whatever the reason, the rhetoric of Democrats in the Trump era, including that of rumored 2020 hopefuls like Gillibrand and Harris, appears to mark a departure from former President Barack Obamas professorial language and Hillary Clintons focus group-tested remarks, representing instead a tone thats angrier and perhaps more authentic.

The political atmosphere has changed since the anomaly of Donald Trump swearing and getting away with it, Indiana University English professor Michael Adams said.

Swearing has been in public spaces over the past few decades, Adams added. Until recently, in political discourse, people thought you needed dignity, and some voters would object to profanity.

That changed during the 2016 election, when Trump used crass and politically incorrect language to send a signal to voters that he was an outsider figure, said Jennifer Mercieca, a communications professor at Texas A&M University.

His whole argument as a candidate was that he wasnt corrupt, and he knew he wasnt corrupt, because he used politically incorrect language as one way to differentiate himself from establishment politicians who followed traditional political norms, Mercieca said.

Trump may have been onto something. His language on the campaign trail and its positive reception by supporters fits neatly into the well-known sociolinguistic theory of overt and covert prestige.

The theory holds that individuals use standard, widely accepted language to gain recognition and status or overt prestige, in linguistics jargon with a wide group of people. In a field like politics, that means using politically correct language that appeals to the broadest swath of voters and offends the fewest and thats what traditional politicians do.

On the other hand, individuals seeking covert prestige with a smaller, specific group of people use language geared toward that audience language that might offend society at large. Politicians often seek covert prestige by using local political dialect to appeal to certain voters, Adams said.

Bill Clinton could speak in a fairly statesperson-like way, but [when] he was talking to people in a small town in Louisiana, he would talk like those people, Adams said.

Then-Republican presidential nominee Donald Trump speaks during the third 2016 presidential debate. Mr. Trump use curse words frequently on the campaign trail. File photo by Joe Raedle/REUTERS

During his presidential campaign, Trump stood out in a crowded Republican field by working profanity into his speeches.

In a November 2015 speech in Iowa, Trump called the press scum and garbage, and announced his plans to bomb the s**t out of ISIS.

In a speech leading up to New Hampshires Republican primary, Trump said companies that move overseas for lower tax rates can go f**k themselves. In the same speech, he attempted to draw a contrast between Obamas work ethic and his own, saying that as president hed abstain from golfing and insteadstay in the White House and work [his] a** off.

Trumps primary opponents adopted his tone and coarser language in their stump speeches and press interviews in a futile attempt to catch up to him in the polls. Sen. Rand Paul R-Ky. said the idea of increasing phone surveillance after a 2015 Paris terrorist attack wasbulls**t. During an MSNBC Morning Joe appearance before he bowed out of the race, Sen. Lindsey Graham, R-S.C., called Trump crazy as hell.

Since taking office, Trump has yet to curse in public, though he has often taken to Twitter to air his grievances. Nevertheless, longtime political observers said Trumps language was part of a broader cultural shift.

Theres a long history of presidents using crude language, but it was mostly done in private.

Trump follows a long line of coarsening in culture in general, whether in music or comedy or movies, said Floyd Ciruli, a Colorado-based pollster. I didnt expect it to jump into politics, especially at the highest level.

Theres a long history of presidents using crude language, but it was mostly done in private. President Richard Nixon was captured swearing often on tape in the Oval Office, but he assumed the conversations wouldnt be made public. President Lyndon Johnson had choice words for his advisors and tailors but they rarely made their way out of the White House.

Being polite was the default of politicians, Chris Hayden, the director of communications for the liberal Center for American Progress, said. Our president has completely thrown that out the window.

As a result, Democrats now feel more comfortable getting looser with their language since there arent severe ramifications for the totally out-of-bound things [Trump] has said, Hayden added.

Hayden said the change could be good for the party because voters like it when politicians can talk like normal people. It demystifies that Washington politician, Hayden said.

With Democrats in the minority in Congress, I think theres a general sense that you have to show passion, resistance to all of these issues that liberals oppose, Ciruli said. Making the language basic and more profane demonstrates that.

Senator Kamala Harris, D-Calif., at a ceremony in Los Angeles on July 3, 2017. Harris and other Democrats have grabbed headlines by dropping curse words in public in recent months. Photo by REUTERS/Mario Anzuoni

In May, during a guest appearance on the popular podcast Pod Save America, Harris grabbed headlines by offering an unusually candid response for a U.S. senator to Rep. Raul Labradors, R-Idaho, claim that nobody dies because they dont have access to health care.

What the f**k is that? Harris said. Her reaction to the House health care bill was not an anomaly. The New York Times reported that the freshman senator is no stranger to curse words.

But Mercieca warns that Democrats need to be careful when using crude language. It can work when trained at unpopular legislation, but can backfire if its used to disparage other politicians, she said.

There are plenty of recent examples of lawmakers profane comments misfiring.

On the Senate floor in 2004, then-Vice President Dick Cheney told Sen. Patrick Leahy D-Vt., to go f**k yourself, a comment that did not sit well with Senate Democrats.

While speaking at an event in New Orleans last weekend Rep. Maxine Waters, D-Calif., ripped into Housing and Urban Development Secretary Ben Carsons credentials to run the department. Waters said she planned to take his ass apart when Carson testified before the House Committee on Financial Services, where she is the ranking Democrat.

The comment drew heavy criticism from conservatives, suggesting that coarse language by lawmakers may rally their partys base, but doesnt necessarily boost bipartisanship.

Democrats will need to figure out the right balance between laying down a well-placed curse word to prove a political point, and coming across as just plain vulgar.

Carolyn Lukensmeyer, the executive director for the National Institute for Civil Discourse, said that by electing Trump, voters clearly rejected political correctness. Still, Americans dont want profanity to become commonplace in political speech, she said.

The public does not want this type of political correctness where politicians talk out of two sides of their mouths, Lukensmeyer said. But also, they arent ready for politicians to use swear words or degraded language about other groups of people.

Polling bears this out. According to a recent NPR/PBS NewsHour/Marist survey, seven in 10 Americans think civility in Washington has gotten worse since Trump was elected. A January poll by the public relations firm Weber-Shandwick found that nearly eight in 10 Americans believed the 2016 election was uncivil. In the same poll, a majority of Trump and Clinton voters 72 percent and 81 percent, respectively said that incivility has risen to crisis levels.

[There is] absolutely no question political discourse and everyday discourse has been profoundly degraded, Lukensmeyer said.

What that means for Democrats who are cursing more frequently remains to be seen, said Hayden of the Center for American Progress. Voters will respond to politicians who show more visceral anger, but Democrats will need to figure out the right balance between laying down a well-placed curse word to prove a political point, and coming across as just plain vulgar.

Thats the line that we draw, he said. The question is, are Americans smart enough to make the distinction.

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What the #$@! Democrats are swearing more. Here's why - PBS NewsHour

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Cards Against Humanity Cleverly Mocks Discrimination With Pricey Pink ‘For Her’ Game – TIME

Posted: at 9:44 pm

Courtesy of Cards Against Humanity

Cards Against Humanity has "released" a new edition of their popular, if politically incorrect game, but this time, it's just for women. The "For Her" set comes packaged in a hot pink box and sports the "For Her" label on its logo, but despite a $5 hike in its cost, the cards are exactly identical to original game sets.

According to a satirical press release, Cards Against Humanity community director Jenn Bane says the decision to make the "For Her" set was because " its 2017, its time for women to have a spot at the table, and nevertheless, she persisted. Thats why we made Cards Against Humanity for Her. Its trendy, stylish, and easy to understand. And its pink."

While the pink set is a joke, its clever commentary on the "pink tax " that women often face. The "pink tax" is a phenomenon where things like personal care items and clothing marketed towards women will sometimes cost as much as 7% more than the same products for men.

Bane told Business Insider that the "For Her" set is a "very stupid" idea and that she doubts that people will actually buy the women't edition.

"Women don't fall for gimmicks, especially not gimmicks as stupid as this one," she said.

However, in case the "For Her" set has as much success as Cards Against Humanity's 2014 Black Friday deal of a box of "bullsh-t" (a literal box of poop,) which ended up selling 30,000 at $6 a pop, the company has committed to giving the profits from the women's edition to Emily's List, a PAC devoted to helping more Democratic women get elected to public office.

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Cards Against Humanity Cleverly Mocks Discrimination With Pricey Pink 'For Her' Game - TIME

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17 ‘Seinfeld’ Episodes Not ‘PC’ Enough for Today – LifeZette

Posted: at 9:44 pm

Viewers of Seinfeld reruns today (and those who watched each new episode as it came out) are in a unique position. The show, which premiered in 1989 and ran through 1998, contains some storylines that many people in 2017 would consider controversial or politically incorrect. Chances are, actually, that some of these Seinfeld episodes might not even make it through production if they were suggested today.

Jerry Seinfeld, the shows star and namesake, has gone on record as saying hes opposed to adhering to political correctness in comedy. Unfortunately, in todays world, everyone is offended by everything which tends to make for some boring TV comedy (and redundant boycotts). Luckily, Seinfeld still airs repeat episodes on a regular basis and has a large cult following.

After a hefty 171-episode binge-watch, LifeZette selected 17 episodesthat probably wouldnt be written today out of fear of criticism from liberal snowflakes and left-wing culture hawks.

Scroll through the gallery to see which episodes probably wouldnt run in 2017without extreme criticism.

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Ode To Joy: ‘Brass Bonanza’ Unites And Excites Whalers Fans, And Is Back In Spotlight – Hartford Courant

Posted: at 9:44 pm

Mike Rotman has heard the song at sporting events all over the country.

Rotman, who grew up in Windsor and lives in Southern California, wears the distinctive blue-and-green of his childhood team when he's at a game. And invariably, folks who see the Whalers logo offer a few bars of that famous little diddy.

"Everywhere I go somebody always sings 'Brass Bonanza' if I'm wearing a Whalers shirt, no matter where in the country I am," Rotman said. "It's insane, man. I'm a little embarrassed by it. I don't look for attention. But people just know it, no matter where I am."

What do people around the country know about Hartford? Sports fans know the Whalers, who departed for North Carolina 20 years ago.

And unlike most professional sports franchises, the Whalers have a soundtrack. The franchise left, but the song remains.

Interest in "Brass Bonanza" has spiked with news that the song's composer died on July 4 in Brussels. Jacques Ysaye, also known as Jack Say, was 94.

His song originally was titled "Evening Beat" and was sold to a musical library. In 1976, Whalers announcers Bob Neumeier and Bill Rasmussen who would later create ESPN used the song as a bridge on the team's season highlight LP.

Whalers executive George Ducharme later told The Courant's Jeff Jacobs that he was looking for a song to get people out of their seats. When he heard "Brass Bonanza," he was hooked.

"Three notes and everybody knows what it is," Ducharme said in 2003. "It's a marketing dream."

All these years later, people still know what it is.

"The song was synonymous to the team," Howard Baldwin said Tuesday. "You think of the song and you think of the team and winning because it was always played after a goal and a win."

Baldwin, one of the founders of the franchise, moved the World Hockey Association team from Boston to Hartford in the mid-1970s. He was always looking for unique ways to sell the team in the new market and the fight song proved to be gold.

Hartford Courant file photo

Not that it was always popular, even within the team offices.

"The hockey guys resisted it a bit in the beginning but then embraced it," Baldwin said. "The visitors hated it."

The song would endure through the 1980s, acting as background music for a generation of hockey fans. Players joked about the song opponents mocked it but it caught on and became part of the scene at the old Civic Center.

Greg Malone spent a few seasons with the Whalers in the 1980s and his son Ryan later played in Hartford as a member of the AHL Wolf Pack. Ryan Malone's memory of Hartford as a 5-year-old kid?

"Obviously, the Hartford Whalers' anthem, the fight song," Malone told The Courant in 2014.

Malone hummed the song. He also told a story about mimicking the song after scoring a goal when he and his brother played indoor hockey with a rolled up sock.

By the late '80s, kids all over Connecticut were humming the song after scoring a goal in street hockey. Rotman's friends at Syracuse University would sing the song after he scored in foosball as a college student in the late '80s and early '90s.

"There was a lot of pride in it," Rotman said. "It was our identity."

Yet in 1992, new general manager Brian Burke replaced the song with a foghorn after the Whalers scored.

"I did it because there were players who were embarrassed by it," Burke later told NHL.com. "An NHL team with a fight song, they were embarrassed by it."

Burke would leave the Whalers for a job with the NHL and "Brass Bonanza" returned. But the team left in 1997, leaving Hartford without a major league franchise.

Still, everything surrounding the franchise lived. The logo endured and the colors, adopted by the Eastern League's Hartford Yard Goats, remained tied to the market.

And as Whalers Nation grew and moved around the country, the song was not far behind. The song became part of the playlist at Fenway Park in the early 2000s, mainly because Enfield native Megan Kaiser was in charge of the ballpark's music.

College bands began playing it. At Endicott College in Beverly, Mass., the song was used at football games because the team was coached by Connecticut native and Trinity graduate J.B. Wells and South Windsor native Marc Zirolli was in charge of the public address system.

That was 14 years ago. The song is now played at college hockey games, at Dunkin' Donuts Park, at high school events, at weddings and on ringtones throughout New England.

Actually, make that ringtones across the country. Rotman, a writer, producer and director whose credits include "Politically Incorrect" and "South Park," has been in Los Angeles since the early 1990s, but he continually returned for Whalers games and will be at Dunkin' Donuts Park for Whalers Alumni Weekend.

Yes, his ringtone is "Brass Bonanza."

"It's just a known entity," Rotman said.

Rotman is the founder of the web-based entertainment network Streamin' Garage and has tried to incorporate the song into his work. He did use former Whalers radio voice Chuck Kaiton, so there is some strong Hartford hockey presence on his site. Kaiton, incidentally, is expected to be in Hartford Saturday for Whalers Alumni Weekend.

When Jacobs tweeted news of Ysaye's death Sunday, Rotman offered this response: "The greatest composer to ever live. No one has touched my life more."

He's not alone. For fans of a certain age, the song is like the soundtrack of a childhood. It's quite a legacy.

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Ode To Joy: 'Brass Bonanza' Unites And Excites Whalers Fans, And Is Back In Spotlight - Hartford Courant

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Armenian Film Festival Sparks LGBT Outrage, Cries Of Censorship – RadioFreeEurope/RadioLiberty

Posted: at 9:43 pm

Armenia's Golden Apricot international film festival has run into controversy as rights activists accuse organizers of censorship for scrapping part of the event that featured two films dealing with lesbian, gay, bisexual, and transgender (LGBT) themes.

The two features, Listen To Me: Untold Stories Beyond Hatred and Apricot Groves, were scheduled outside the competitive portion of the weeklong festival under the rubric Armenians: Internal And External Views.

Festival organizers, however, canceled the entire slate of 36 films by Armenian directors, as well as foreign productions about Armenia and Armenians, to be shown in the section, saying only that they "apologize for any inconveniences."

The move immediately sparked a backlash from filmmakers and rights groups who said it was a thinly veiled attempt at censorship reminiscent of the Soviet era and the Ottoman Empire.

"We condemn the actions of both the Union of Cinematography of Armenia, that has dared to censor the special program of the Golden Apricot International Festival because of the themes broached in the films Listen To Me: Untold Stories Beyond Hatred and Apricot Groves," more than 100 of the country's filmmakers, artists, and rights advocates said in a letter to the organizers.

"Golden Apricot should immediately restore the screening of all films regardless of the format. Otherwise the Golden Apricot International Festival should accept that they are the ones who are legitimizing the censorship and changes in the festival."

Facing Prejudice

Though homosexuality has been legal in Armenia since 2003, the subject is still taboo within Armenian society, which is firmly guided by the Apostolic Church.

The country does not recognize formalized same-sex relationships performed locally, has no antidiscrimination laws, and gay men are declared mentally ill and unfit for military service.

In the documentary Listen To Me, written by Hovhannes Ishkhanyan and directed by Gagik Ghazerah, 10 members of the LGBT community relate their experiences of coming out to their friends, families, and community.

Included in the group is Tsomak Oganezova, the owner of a gay pub in Yerevan that was firebombed and vandalized with Nazi symbols in 2012. Oganezova has said she left Armenia after the attacks "to be with those like me."

Pouria Heidary Oureh's Apricot Groves is about Aram, an Iranian-Armenian trans man who has lived in the United States since childhood. The story follows him as he returns to Armenia to meet his girlfriend's conservative family and make preparations for their marriage.

Both films have already been featured at festivals around the world.

"Understanding the fact that this is not only discrimination against the Armenian LGBT community, and a violation of freedom of expression and freedom to create, but also a slap to Armenian cinematography, we are calling upon the Ministry of Culture of Armenia, the staff, and sponsors, and partners of the...festival to put all their efforts to restore the whole...program," supporters wrote in a petition to Culture Minister Armen Amiryan*, the Cinematographers Union, and festival organizers.

'Officially Sanctioned Hate'

Given the hostile conditions they face, many LGBT people say they remain closeted to avoid discrimination and violence.

In 2015, a local tabloid outed dozens of LGBT advocates, calling on readers to shun them and providing links to their Facebook profiles. The victims filed suit against the publication, but the court ruled in favor of the paper and made the plaintiffs pay $100 in fees.

That incident came after a 2012 study was published showing 55 percent of Armenians would reject a friend or relative if they came out.

"Hate speech in Armenia is rising day by day," activist Mamikon Hovsepyan said after being one of the journalists outed by the tabloid. "The homophobic media has the support of government officials and promotes aggression and hate toward LGBT people."

This year, jury members at the Golden Apricot festival include Britain's Hugh Hudson, who directed the Oscar-winning 1981 epic Chariots Of Fire, and Dutch director Tom Fassaert.

*CORRECTED from original version.

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Armenian Film Festival Sparks LGBT Outrage, Cries Of Censorship - RadioFreeEurope/RadioLiberty

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AP Stylebook Updates Spur Controversy Over Worries of Conservative Censorship – Washington Free Beacon

Posted: at 9:43 pm

BY: Katelyn Caralle July 11, 2017 10:36 am

The Associated Press Stylebook, the traditional journalist stylistic handbook for decades, has sparked controversy over new updates that have right-leaning journalists and politicians concerned about potentially biased language.

The AP annually updates its stylebook in the spring to give journalists guidance on style and grammar. These changes are often analyzed and publicized, but the most recent updates have some observers particularly concerned.

Fox News host Shannon Bream on Tuesday listed changes that have some people questioning if the intent is to censor words more likely to be used by conservatives.

"The AP Stylebook tells people to change pro-life' to anti-abortion,'" Bream reported. "Militant,' lone wolves,' or attackers,' those are the preferred terms rather than terrorist' or Islamist.' And illegal immigrant' or undocumented,' well those are no longer considered acceptable words."

Dave Hoppe, former chief of staff to House Speaker Paul Ryan (R., Wis.), discussed the importance of language and the AP's changes along with the campaign director at the Center for Progress Action Fund, Emily Tisch Sussman.

"The thing you have to look at is that use of language is a very powerful tool. And to make choices like this, and I think in some cases bias choices like this, is something you have to watch very carefully," Hoppe said. "In extreme cases, this is actually censorship. So one has to be careful and be fair to use the language that both sides like."

One change that seems to be causing the most discussion is the disparity between "pro-life" and "anti-abortion."

Bream read off the change that instead of using "pro-choice" or "pro-abortion," journalists should use "pro-abortion rights." The AP also guides journalists to no longer use the term "abortionists" because it claims that term only refers to people who perform clandestine, or unsafe, abortions.

Bream then asked whether it is possible for language to truly be neutral in any story that raises such controversial and emotional topics.

Sussman said these standards exist so everyone can agree on and be aware of what is being reported.

"It's important to have a distinction if you are anti-abortion, pro-abortion, or pro-choice. There are people who can be anti-abortion and pro-choice, that is possible," Sussman said. "So I think it's important that we have clear guidelines."

"Use the word pro-life,' that is the phrase preferred by people who are pro-life. There's no problem in using it; it's not confusing to people to use it. It's very clear what they mean," Hoppe said. "That you use one set of words as opposed to the other and are told specifically not to use a certain set of words, it seems to me is bias and that's where the power of language can come in to try and turn people's minds and turn their thoughts away."

Sussman disagreed, arguing that it is important to be as specific as possible when talking about emotional issues like abortion and immigration.

"I do think that being anti-abortion is as specific as possible. I don't think that being pro-life is as specific as possible," Sussman said. "That would imply that someone would be pro-life in other contexts like death penalty or health care."

"To choose the language that someone prefers, I don't think is specific," she added. "As culture is moving, our definitions have to evolve as well."

Some other AP guideline amendments include calling migrants or refugees fleeing to Europe "people struggling to enter Europe." The AP also says that journalists should describe people who dispute that the world is warming as either "climate-change doubters" or "those who reject mainstream climate science."

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AP Stylebook Updates Spur Controversy Over Worries of Conservative Censorship - Washington Free Beacon

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Egyptian Artists Continue to Produce Thrilling Art Despite Increased Censorship – Egyptian Streets

Posted: at 9:43 pm

Egyptian Artists Continue to Produce Thrilling Art Despite Increased Censorship

The arts and culture scene in Egypt has been Oxygenating the freedom of expression discoursedespite battling against repression and government censorship.

In recent years, creative works of artstarting from music productions, television series or filmshave faced many legal consequences suffocating the creative process.

The independent Egyptian rock band Cairokee was set to launch their latest albumNotaa Bedaor A Drop of White. However, on 2 July, Cairokee announced that the General Authority for Censorship of works of art rejected a number of songs and prevented the distribution of the album in the market.

18 Days is an Egyptian film focusing on the 18 days of the 2011 Egyptian revolution. It premiered at the 2011 Cannes Film Festival and has been banned to be aired in Egypt since then. The film combined glossary of directors, sound engineers and editors among others to produce a film with many Egyptian artists on voluntary basis.

On 4 July, the film has been leaked on the internet allowing people to view it after many years of unjustified ban.

While Ramadan television series represent a great opportunity for artists to show off their best talents, clever scripts, thrilling events and smart directing, lawsuits remain an annual obstacle that impose censorship restrictions on Ramadan biggest hits.

This year, Ramadan seriesLa Totfe El Shams,or Dont let the Sun Set, faced a lawsuit on claims of offending the president. The lawsuit cameafter airing episode number 14 was aired showing a graffiti on a wall that says Sisi the traitor.

The Association from Freedom of Thought and Expression (AFTE) and The World Forum on Music and Censorship (FREEMUSE) have conducted a study called Censors of Creativity that explores case studies of artistic censorship tracing legal cases from courts, local news and international conventions.

Article 1 of the law [38/1992]states that the objective of the censorship of cinema, theater, musical works, and the performing arts is to protect the public order, public morals, and the higher interests of the state, stated in the study.

However, the effects of art censorship or unjustified restrictions of the right to freedom of artistic expression and creativity are devastating,according to researchers in the study.

Historically, contemporary arthas beenapowerful and impactfulway to address pressing political and social issues. Egyptian artists continue to work around the oppression and censorship in Egypt.

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