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Category Archives: Transhuman News

Root of cardiac fibrosis defined – Medical Xpress

Posted: July 13, 2017 at 6:44 am

July 13, 2017 by Nora Dunne Localization of pro-fibrotic hormones in heart muscle cells (green), which synthesize and release transforming growth factor-beta (red) following cardiac injury. Nuclei are shown in blue. Credit: Northwestern University

Northwestern Medicine scientists have identified a novel molecular mechanism that regulates scar formation in the heart, a common manifestation of aging and nearly every form of heart disease. The discovery was published in the journal Circulation.

The scientists showed that heart muscle cells called cardiomyocytes are a principal source of the molecular signals that drive scarring in the heart, a process known as cardiac fibrosis.

"Historically, these signals were thought to arise from other cell types in the heart," explained Panagiotis (Peter) Flevaris, MD, PhD, '12, '17 GME, instructor of Medicine in the Division of Cardiology and first author of the paper. "We also identified the gene that serves as the master regulator of the synthesis and release of pro-fibrotic signals from heart muscle cells across different species."

First, Flevaris and colleagues showed that a familial mutation in that gene, which encodes the protein plasminogen activator inhibitor-1 (PAI-1), leads to spontaneous cardiac fibrosis in otherwise healthy individuals in an Old Order Amish community. The findings in the human population confirmed previous observations in mice lacking the gene for PAI-1.

Importantly, the scientists found that a protein called bone morphogenetic protein 7 (BMP7) can prevent the generation of fibrotic signals by cardiomyocytes and may be able to serve as a future therapy for cardiac fibrosis.

"Tissue fibrosis is the leading cause of organ failure, but persists as one of the most pressing global health problems due to lack of effective pharmacotherapies. Currently, the only cure for cardiac fibrosis is heart transplantation," said Flevaris, who completed this research during a post-doctoral fellowship in the Department of Medicine's Physician-Scientist Training Program, working with senior author Douglas Vaughan, MD, Irving S. Cutter Professor of Medicine and chair of Medicine.

"Supported by clinical and functional data, our work provides exciting new evidence that modulation of cardiomyocyte signals by BMP7 represents a unique therapeutic strategy to prevent cardiac fibrosis," Flevaris added. "This discovery not only provides a novel paradigm for how the heart muscle generates signals following injury, but also has the potential to transform healthcare for the heart failure population at large."

Explore further: Study shows cardiac fibrosis reversal through gene targeting in heart failure models

More information: Panagiotis Flevaris et al. PAI-1 Controls Cardiomyocyte TGF- and Cardiac Fibrosis, Circulation (2017). DOI: 10.1161/CIRCULATIONAHA.117.028145

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In Brazil, Lula conviction opens field for 2018 presidential race – Reuters

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BRASILIA (Reuters) - The graft conviction Wednesday of former Brazilian President Luiz Inacio Lula da Silva, a front-runner for next year's presidential election, opens the door for an outsider to take power in Latin America's largest country, political experts said.

Lula, a giant on the Brazilian political scene who led Brazil from 2003 to 2011, has said he wants to run for president again next year. But if his nearly 10-year sentence is upheld on appeal, Lula, a founder of the leftist Workers Party, would be barred from seeking office again for eight years, beginning after any jail time is complete.

Lula, 71, is among a raft of Brazilian elites toppled by an epic corruption scandal that has battered the nation's economy, engulfed every major party and deepened public cynicism about politics. It's a toxic mix that has enraged voters, who are searching for someone to lead them out of the political and economic wilderness.

"Brazil is now as polarized as the U.S., it really has been for years," said Carlos Melo, a political scientist with Insper, a Sao Paulo business school. "But if Lula is absent it would unquestionably open the space for an outside, very emotional leader, a bit like U.S. President Trump."

Lula was convicted on Wednesday by Judge Sergio Moro, who found Lula guilty of accepting 3.7 million reais ($1.15 million) worth of bribes from engineering firm OAS SA [OAS.UL]. That is the amount prosecutors said the company spent refurbishing a beach apartment for Lula in return for his help winning contracts with state oil company Petroleo Brasileiro.

OAS was part of a supplier cartel that prosecutors said fleeced billions of dollars from Petrobras through inflated contracts, funneling some of the ill-gotten gains to politicians and political parties. Several OAS executives were jailed by Moro, the hard-charging judge overseeing the so-called Car Wash investigation, the largest-ever corruption probe in Brazils history.

Lula' lawyers said he is innocent. He will remain free while his attorneys appeal the ruling, which they have characterized as a political witch hunt. The appeals court is expected to take at least eight months to rule.

"This politically motivated judgment attacks Brazil's rule of law, democracy and Lula's basic human rights," Lula's defense team wrote in an emailed statement. "It is of immense concern to the Brazilian people and to the international community."

Despite his legal woes, the charismatic Lula remains Brazil's best-known politician and has retained a base of loyal supporters. As president, he channeled resources from a commodities boom into social programs that helped lift millions from poverty.

Recent surveys from the respected Datafolha polling institute show that in a second-round runoff next year, Lula would beat all contenders with the exception of the environmentalist and two-time presidential candidate Marina Silva, with whom he is in a technical tie.

But if Lula cannot run, and with roughly 20 percent of the electorate undecided on any candidate, the election is up for grabs.

While Silva has polled well, Melo and other political watchers doubt that the soft-spoken, environmental expert could win, in part because her campaigns have lacked the fiery speeches and dramatic flair needed to engage many voters.

The public's thirst for showmanship and anti-establishment candidates, Melo said, could give a boost to two outsiders: Ciro Gomes, a tough-talking former governor, federal minister and congressmen who is now with the Democratic Workers Party; and Joao Doria, a millionaire media mogul and former star of Brazil's version of "The Apprentice."

Gomes, despite his long career in politics, is a rough-and-tumble politician who could easily position himself as an anti-government candidate. Loud and politically incorrect, Gomes called unpopular President Michel Temer, himself facing a corruption charge, the "captain of the coup" that led to the impeachment of former President Dilma Rousseff last year.

Doria, who had never held elected office before, stunned the political establishment last year when he won the mayorship of South America's largest city in the first round, capturing 53 percent of the vote. A member of the centrist Brazilian Social Democracy Party, he is loved by the business community for his pro-market stance. And he has caught the public's attention with stunts such as donning a street sweeper's uniform and spending days cleaning roadways.

Shortly after the Lula verdict was made public Wednesday, Doria posted on Twitter that "Justice has been done."

"The most shameless man in Brazil was condemned to nine and a half years in prison," Doria continued. "Long live Brazil."

The latest Datafolha polls shows Gomes and Doria in a technical tie in a second-round presidential vote next year.

A right-wing, law-and-order candidate, congressman Jair Bolsonaro, of the Social Christian Party, also has polled well, taking 15 percent of a simulated first-round vote in the Datafolha survey, putting him behind only Lula.

But political watchers caution his appeal is likely to wane as opponents dig into his trove of anti-gay, pro-dictatorship utterances. Bolsonaro is facing a trial before Brazil's Supreme Court for inciting violence after he told a female congresswoman on the floor of the lower house that he "would not rape her because she would not be worthy of it."

Sergio Praca, a political scientist at the Getulio Vargas Foundation, a leading Brazilian University, said he sees the Lula conviction as giving all politicians a deep scare rather than any one candidate a bounce.

"This conviction is a black mark on Brazil's history. But it is a great moment in the fight against impunity," Praca said.

"The Brazilian voter will no longer accept a presidential candidate who is not clean, and that is a real evolution in our democracy," he added. "In this trying moment, that is the positive outlook we have to hold onto."

Editing by Marla Dickerson

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YouTube Star Attacked Following Comments About Gender – The Daily Caller

Posted: at 6:44 am

YouTube feminist Laci Green, who enjoys a popular following of over 1.5 million subscribers, has become persona non grata among the social justice crowd for daring to question feminist orthodoxy and for dating a man on the other side of the political aisle. Recently, Green has taken to publicly questioning her previously held beliefs about gender and the sex binary, which has earned her the scorn of feminists who are accusing her of bigotry.

To a mainstream audience, the spats that happen on Twitter may seem like pointless drama but given the broad reach of all the personalities involved, these arguments have a trickle-down effect that affect millions of the viewers who watch their videos and listen to what they say.

Recently, Green took issue with a Vogue magazine infographic describing females as non-prostate owners.

This is what Im talking about when I say I cant even use basic biology terms in sex ed anymore, commented Green, adding that terms like male and female are now politically incorrect and not inclusive.

Female and male are not identities or genders, she continued. There are biological sexes and refer to someones literal body parts (for reproduction).

Its basic biology that anyone will learn in high school.

In a separate tweet, Green highlighted opinions she held that are considered controversial in 2017. She described same sex attraction as gay.

While many other users on Twitter expressed their support for her views, an equal number of feminists especially male feminists were upset by what she wrote.

Following her comments, Green was attacked for being a TERF or trans exclusionary radical feminist, which describes a fringe section of feminists who exclude transgender people from the discourse. Others accused her of homophobia and biphobia, for stating the obvious that same sex attraction is gay.

Many implied that she only held her beliefs because of who she was dating, and not because she was capable of thinking for herself.

Another popular YouTuber, Daniel Hardcastle, who once described Feminist Frequency as trash, weighed in on the situation by aligning himself with Greens detractors and cried about ableism when he was called out on it.

Its curious to see where the lines will be drawn in the ongoing discussion on political correctness and the language of sex and gender as more young people rise to prominence within the media.

Ian Miles Cheong is a journalist and outspoken media critic. You can reach him through social media at @stillgray on Twitter.

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Album Review: Jay-Z Makes You His Therapist on the Confessional 4:44 – Student Edge

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Album Review: Jay-Z Makes You His Therapist on the Confessional 4:44
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Describing himself with psychoanalytical language like emotionally available, and amending his comments when he's politically incorrect, the unretired and very apologetic Jay uses his comeback record to respond to wife Beyonc's adultery ...

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Conor McGregor’s only hope: Dial up the antics and get under Floyd Mayweather’s skin – Yahoo Sports

Posted: at 6:44 am

TORONTO Speaking into a working microphone (this time), and to a rabid, yet supportive crowd (as always), Conor McGregor came to Canada on Wednesday and spent his afternoon ridiculing Floyd Mayweather in nearly every imaginable way with profanity, politically incorrect comments and, mostly, biting humor.

Mayweather may have every advantage in their Aug. 26 boxing match in Las Vegas, but on this wild, free-wheeling, four-city, three-country promotional tour, its McGregors game they are playing. Mayweather is one hell of a promoter, but McGregor is a showman for the ages.

The problem is it probably wont help him come fight night.

Despite gray skies and a light rain, over 10,000 rowdy fans descended on an outdoor, lake-front amphitheater here to watch McGregor strut around and mercilessly mock Mayweather.

He hit Mayweather on The Money Team casual attire He looks like a little break dancer Youre 40 years old, dress your age.

He hit Mayweather on the strip club he owns in Vegas Fifty strippers on his payroll. At least Rob Kardashian only had one.

He hit Mayweather on his less-educated background You cant read.

I dont read, Mayweather shot back later, quickly shifting to his ability to bank dollars as the worlds highest-paid athlete. I do numbers. I make money.

You owe money, McGregor interrupted, slamming Mayweather for his recent $22 million IRS lien, which will be handled with part of his earnings for the bout, which projects to be the richest prize fight in history.

The crowd soon started chanting, Pay Your Taxes.

Floyd Mayweather (L) and Conor McGregor yell at each other during their news conference on Wednesday in Toronto. (Getty)

Toronto in particular, and Canada in general, is an MMA stronghold. It is such a reliable market for the Ultimate Fighting Championship that the promotion routinely stages shows up here, including its first ever in a stadium, drawing 55,000-plus back in 2011.

As such, Mayweather never really stood a chance. This was a McGregor event. When McGregor hit, the crowd roared. When Mayweather countered, they booed.

There was a classic tell in McGregors comments, though, a sign that he was thinking about more than just selling $99.99 pay-per-views. McGregor isnt the greatest fighter, but he is a very clever and calculating one. So while he wants to show the people a good time, he also wants to rattle Mayweather, upset him enough to move him off his game and into an act of ill-advised fight-night rage.

The proof came when he mentioned his December 2015 bout against Jose Aldo, a man that was then on a 10-year unbeaten streak and considered the best pound-for-pound fighter in the UFC.

They said the same thing then as they are saying now, McGregor crowed. They said I had no chance. They said Im in over my head. They said he kicks too hard. They said he had too many weapons.

It took me two whole seconds

Actually, 13 seconds, but the specifics dont matter. McGregor spent years not merely months in the buildup to the fight hammering and humiliating Aldo with his sharp tongue and vicious wit. He was so relentless on the soft-spoken Brazilian that when they squared off at the weigh-in, he noticed Aldos right hand, twitching. McGregor then, before the fight, predicted to the English-speaking media how it would end.

Hes ready to unload that right hand and I feel that could be the downfall for him, McGregor predicted. If he lets that right hand go, I will not be there I will create traps and dead spaces in the Octagon. I will walk him into that dead space. All of a sudden, he will be in danger.

Sure enough, Aldo, who should have sat back and tried to get McGregor to the ground, charged at the opening bell and threw a wild right that grazed McGregor. It also led Aldo into that predicted dead space, where a McGregor left ended the fight in an instant.

It was Mystic Mac at his finest. It also represents one of the few paths to victory he can attempt in a boxing match against the 49-0 Mayweather: Get him so mad that he tries to kill you and then counter with a knockout.

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Its hard to believe he can out-point Floyd Mayweather, UFC president Dana White said Wednesday. Its a fight, though. When guys are throwing punches, anything can happen.

Sure, unless Mayweather is cautious and simply ducks them all. Which is why the antagonize game isnt just worth a try, it may be the only try.

His head is too small, McGregor cracked, while questioning Mayweathers toughness and durability. One shot is all it will take. He hasnt fought a day in his life. Hes a runner. Hes boxings biggest [expletive].

Except there was Mayweather standing behind the amphitheater after the promotional show Wednesday, laughing at McGregors one-liners, brushing off any concerns about what got said and nodding approval at McGregors hustle.

If one of the goals here is to get under Mayweathers skin, it doesnt appear to be working.

Its about giving the people entertainment, Mayweather said calmly. People want to be entertained. And I think both press conferences [here and Tuesday in Los Angeles] have been unbelievable.

I mean, Im not upset with him, Mayweather continued. Its not like the guy has done something harsh to me. It has nothing to do with talking. Ive been world champion for 19 years. Ive never been overthrown. Its all about keeping my composure. Anytime I went out there and competed against the best guys in boxing, I kept my composure. I went out there and executed the gameplan Im the best in the business. We have to be sharp. We have to be smart.

Its worth pointing this out: At the two lengthy staredowns here, Floyd Mayweathers hand never twitched. And its unlikely it ever will.

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Donald Trump Jr. loves far-right internet trolls and they love him back – Salon

Posted: at 6:44 am

Donald Trump Jr., son of President Donald Trump, frequently uses his prominence on Twitter and proximity to the White House to promote right-wing media trolls who defend his father and smear mainstream media.

Key voices in the incestuous right-wingalternative media ecosystemhave found an ally in the younger Trump, who often retweets and favorites tweets from the echo chambers loudest voices, and who isrumoredto serve as a White House source to at least one far-right personality. Like the far-right trolls he expresses admiration for, Trump spends his time on Twitterspreadingdebunked conspiracy theories,smearingmainstream media outlets,promotingbogus alt-right videos, andamplifyingmessages with white nationalist undertones. Trumps behavior, in effect, validates the larger alternative media ecosystem and attempts to bring the fringe worldview into the mainstream.

Mike Cernovich

Trump has repeatedly indicated an affinity for right-wing troll and Infowars contributor Mike Cernovich. Cernovich gained notoriety during the 2016 election for promotingfakeconspiracytheoriessuch as the Pizzagate narrative, accusing Democratic officials of operating a child sex trafficking ring in the basement of a Washington, D.C., pizzeria. Infowars Alex Jones told his audience that the presidents sons, especially Donald Jr.,are Cernovichs sourceson White House affairs. And earlier this year, Trump claimed that in a long gone time of unbiased journalism Cernovich would win the Pulitzer prize for hisfaux scandal storythat alleged Susan Rice, who served as national security adviser to then-President Barack Obama, was responsible for improper unmasking of Trump associates caught in surveillance of foreign officials.

Stefan Molyneux

The younger Trump alsofrequentlyretweetsStefan Molyneaux, a prominent far-right blogger whopromotesright-wing trolls and conspiracy theories about globalism. Trump closely follows Molyneaux, boosting many of his tweets and favoritingonethat featured a depiction of CNN reporter Andrew Kaczynski in a Nazi uniform.

Infowars Alex Jones and Paul Joseph Watson

Infowars top conspiracy peddlers, Paul Joseph Watson and Alex Jones, also have Trumps attention. During the 2016 election, Trumpshared an Infowars articlethat falsely accused Democratic presidential nominee Hillary Clinton of wearing an earpiece during the first presidential debate. Trump has alsoliked tweetsfrom Watson and recentlyattacked CNNwhile Infowars was pushing a meme war against the network.

4chan

While he wassharing anti-CNN memes, Trump also favorited atweetfrom a Twitter account connected to the internet cesspool known as 4chans politically incorrect message board (/pol/). The tweet contained a list of companies that advertise on CNN and encouraged people to tweet at the companies and ask them to stop advertising on the network. Alongside far-right ideologies, the board often features anti-Semitic, racist, sexist, homophobic, and white nationalist content.

Jack Posobiec

Trump also promotes right-wing troll Jack Posobiec on Twitter. Posobiecspublicity stuntsandbogus talking pointshave duped mainstream media sources and public officials. On July 8, Trumpshared a videoPosobiec posted that depicted protesters setting fires in Germany in response to the G-20 summit. Posobiec is a media troll who got temporary White House credentials to attend the press briefings. He is responsible for peddling hacked emails that were likely sourced from Russia, spreading the Pizzagate conspiracy, and orchestrating smear campaigns against people who opposed the senior Trump.

Trumps affinity for these far-right media personalities and his active promotion of their half-baked theories about the days news validates the alternative media ecosystem to its audience and furthers the far-rights attempt to delegitimize longstanding journalistic institutions. By emulating and affirming these fringe figures, Trump furthers his fathersdisdain for the pressand stokes public distrust of legitimate news outlets.

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El Salvador media bill prompts ‘censorship’ claim – BBC News – BBC News

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El Salvador media bill prompts 'censorship' claim - BBC News
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The government says the press should self-regulate violent stories to help the nation's mental health.

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Ron Paul calls steel import tariff ‘immoral’ – Fox Business

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Former Congressman Ron Paul (R-Texas) said President Trumps proposed import tariff on foreign steel is simply immoral.

It should be immoral to prohibit people from buying stuff where they want to. In a free society, youre supposed to protect that not interfere with that, Paul told FOX Business Kennedy.

The European Union (EU) has threatened to retaliate the Trump administrations proposed import tariff on foreign steel, by creating an import tariff for bourbon.

Theres a downside, there [are] repercussions from [imposing tariffs] and they retaliate and put taxes and prohibitions on our products, which is what theyre hinting at right now, he said.

However Paul believes the solution does not need to come from managed trade agreements.

The bilateral agreements make more senseif we would have an agreement on lumbers, say with Canada, and nobody else is interfering, it should be worked out and maybe there would be a time where you really would have free trade across the borders that touch your country, he said.

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Fanning the Flames of Liberal Paranoia About Libertarians – Independent Women’s Forum

Posted: at 6:42 am

July 12 2017

by Charlotte Allen

Democracy in Chains.

That's the book's title. Must be about the Iron Curtain or Cuba--or to bring us up to date, Venezuela, right?

Not so. The subtitle of the book, witten by Duke University historian Nancy MacLean is The Deep History of the Radical Right's Stealth Plan for America.

Oh. The main theme of the book, according to what I've read, is that well-funded libertarians eager to impose economic inequality and serve the interests of rich white men are ganging up to get the courts to enforce those un-democratic institutions called property rights. You know, like preventing your home from being seized by the city you live in because the city council decides to replace it with some condos that never get built. Oh wait! Kelo vs. City of New London went the other way! The Supreme Court ruled that the displaced homeowner, nurse Susette Kelo, had to suck it up because the condo plan served a "public purpose"--so yay, democracy! What's McLean's problem?

Her problem, it turns out, are those perennial liberal arch-villains, billionaires Charles and David Koch, who fund a lot of libertarian think tanks and university research centers employing libertarian professors..

So naturally, liberals have been out of their minds with praise for Democracy in Chains. "This sixty-year campaign to make libertarianism mainstream and eventually take the government itself is at the heart of Democracy in Chains. . . . If you're worried about what all this means for America's future, you should be," gushes NPR, which is funded by us taxpayers, so it's democracy.

But not everyone is onboard the Chains train. David Bernstein, a law professor at George Mason University, writing in the Washington Post, argued that MacLean simply got a lot of her facts wrong, especially about James Buchanan, a libertarian economist who got a Nobel prize in 1986 for his "public choice" theory--the idea that government bureaucrats aren't neutral public servants but have a vested interest in keeping their bureaucracies big and powerful (MacLean argued that Buchanan was the architect of a movement to make libertarianism mainstream):

I only met Buchanan once, at an Institute for Humane Studies gathering for young libertarian academics around 20 years ago. The devil himself (Charles Koch) was there. Buchanan gave the keynote address. What did this arch defender of inequality and wealth talk about? He gave a lengthy defense of high inheritance taxes, necessary, in his view, to prevent the emergence of a permanent oligarchy. Not surprisingly, perhaps, Democracy in Chains fails to note Buchanans strong support of inheritance taxes. [Update: He in fact publicly supported a 100% inheritance tax.]...

Furthermore, MacLean tries to claim that libertarians backed Southern resistance to court-imposed racial desegregation as part of a "noble quest to preserve states' rights and economic liberty." Her sole publicly available citation is to an article by libertarian Frank Chodorov that she says criticized the Supreme Court's 1954 school-desegregation decision, Brown vs. Board of Education. In fact, as Bernstein points out, the article by Chodorov praises the Brown ruling as "in line with what is deepest and strongest and most generous in our historical tradition."

Bernstein was not the only scholar to take MacLean to task for mischaracterizing a range of libertarian thinker and their ideas. So now, according to Inside Higher Edication, MacLean is claiming an evil radical right conspiracy is at foot to discredit her book, financed of course (if indirectly) by none other than...the Koch brothers! So she apparently did what every liberal professor does when faced with an evil radical-right conspiracy: go on the Internet to get her liberal professor friends to write rave reviews of her book on Amazon:

In a social media postthat MacLean did not authenticate to Inside Higher Ed, but which hasbeen widely shared online by her supporters, she allegedly asked friends and colleagues to help defend her book against an apparentcoordinated attack.

I really, really need your help, MacLean is said to have written. This will sound nutty, I know, but its actually happening: the Koch operatives and the riders of their academic gravy train, as James Buchanan called it, are working very hard to kill Democracy in Chains -- and to destroy my reputation (as they have done to climate change scientists and others bearing inconvenient truth).

By using thePost blog posts, the notesays, critics"make it appear to the ordinary web surfer that the [newspaper] itself is trashing my book when its really the Koch team of professors who dont disclose their conflicts of interest and the operatives who work full-time for their project to shackle our democracy. The other side was getting top placement because their team was clicking and reclicking and sending embedded links, and the velocity of their activity drove up their links. (It should be noted that the blogs in question are affiliated with the Post, but authors' views are solely their own.)

The notesuggests that supporters can help by googling MacLean and her book and clicking on real listings to push them above allegedlypaid returns, and promoting as "helpful"Amazon reviews that appear authentic. "The operatives are juking the Amazon stats so that their hit jobs (by people who in nearly every case never read the book) come up first by the number of 'helpful'votes," it says. MacLean alsowarned readers about a propaganda-style wiki page set up by someone with a pseudonym.

People: this is real, the postreads. I wont be the last they set out to get."

Inside Higher Ed further reports:

MacLean did not respond to a request for hard evidence of the Amazon review gaming.

Bernstein, meanwhile, has called MacLeans allegations fanciful and potentially libelous." Although George Mason, many of whose law and economics professors are libertarians, has been the beneficiary of millions of dollars' worth of Koch funding, Bernstein told Inside Higher Ed that no one "urged me, asked me, beseeched me, paid me or otherwise tried to influence me to blog about the book.

The one thing to be said about MacLean's alleged social-media plea is that it sounds about as conspiracy-obsessed as her book. At the risk of sounding conspiracy-obsessed myself, I can't help thinking there's a plot afoot to make libertarians pariahs in the academic community.

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There’s No Harm in Fantasizing About a Better Future – Reason (blog)

Posted: at 6:42 am

In Radicals for Utopia, published last month, journalist Jamie Bartlett profiles Zoltan Istvan, who ran for president under the Transhumanist Party's banner in 2016. Along with several other journalists, Bartlett traveled across the southwest on Istvan's "immortality bus" (a rickety camper shaped like a coffin-slash-log cabin), and watched Istvan preach the gospel of transhumanism to fellow futurists and skeptics alike.

"Transhumanist science is undeniably exciting and fast-moving," Bartlett writes of watching Istvan tell a half-empty auditorium in Las Vegas that humanity will conquer death within 15 to 25 years. "But the science is not almost there."

He knocks Istvan for "flit[ting] with misleading ease between science and fiction, taking any promising piece of research as proof of victory." In another scene, Bartlett channels the frustration of other futurists who have tired of the transhumanism project altogether. "Transhumanists have been promising us jetpacks and immortality," one biohacker tells Bartlett. "We're sick of [their] bullshit promises." Later, we learn that Istvan is not particularly liked by even other transhumanists, that he is terrible at leading a political party, and that the chief goal of his campaign was to get people to pay attention to him. In other words, that he is like every other person who has ever run for president.

After painting Istvan as bumbling (when the immortality bus breaks down) and unscientific (when he expresses enthusiasm for cryogenics), Bartlett describes him as something like a villain.

"Transhumanism feels like the perfect religion for a modern, selfish age; an extension of society's obsession with individualism, perfection and youth," he writes. He accuses Istvan of "ignor[ing] current problems and overlook[ing] the negative consequences of rapidly advancing technology." It's an odd claim considering Istvan's presidential platform called for "the complete dismantlement and abolition of all nuclear weapons everywhere, as rapidly as possible." Nuclear weapons were once a rapidly advancing technology, they are currently a problem, and Istvan seems to be quite concerned about their negative consequences.

It's an even odder claim considering that the people who are dedicating themselves to the problems du jour don't seem capable of actually fixing any of them. Last I checked, the Israelis and Palestinians are still at it. Al Qaeda, too. The world is less poor than it once was, but there are still three-quarters of a billion people living in extreme poverty. In the U.S., black lives still matter less than blue and white ones. Is this really transhumanism's fault? What would Bartlett have Istvan do? Go back in time and donate the money he spent on the Immortality Bus to Hillary Clinton?

Bartlett then tells us that many other technologists and intellectuals are opposed to the world Istvan hopes one day to live (forever) in. Elon Musk "declared AI to be comparable to summoning the Devil," he writes. "Stephen Hawking said 'the development of artificial intelligence could spell the end of the human race.'" Francis Fukuyama "called transhumanism 'the world's most dangerous idea.'" Artificial intelligence seems to worry Barlett more than Istvan's other enthusiasms. He notes that self-driving cars will likely displace human truckers and that drones will displace human warehouse workers. Apparently, no one wants to live in a world where poor little boys and girls can't realize their dreams of living out of a long-haul cab and inhaling particulates in storage facilities.

All things considered, Bartlett's treatment of Istvan the candidate is fair. Anyone who desires the powers of the presidency deserves, at the very least, to have his or her vision for the job harshly interrogated. And many aspects of Istvan's vision are pie in the sky. But the techno fear-mongering throughout the rest of the chapter feels off. Everyone can't be expected to worry about everything, and there are plenty of people in Silicon Valley worried about the ramifications of automation and sentient machines. There's Musk, and also Y Combinator, which is running a basic income experiment right now in anticipation of a world with fewer menial jobs for humans. (Bartlett also notes that AI may displace doctors and lawyers, but he reduces it to an employment problem without acknowledging that it might also mean fewer misdiagnoses and overall better care.)

Nobody in Silicon Valley, or outside it, knows which line of inquiry will prove fruitful, or when. Ascribing carelessness, or malice, to the people pursuing those experiments is a disservice to the spirit of inquiry itself. As Scott Alexander noted in May, many of these folks are working on some rather amazing, life-affirming, world-improving applications. Regardless, it is farcical to lay blame for the bad (or the good) at the feet of transhumanists, who are mostly fanboys of the next big thing, not the people making it. And it is particularly disappointing to see someone bash these people for imagining how they might enjoy a future none of us can stop.

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There's No Harm in Fantasizing About a Better Future - Reason (blog)

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