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Category Archives: Transhuman News

Post-marketing data reinforce sustained efficacy and safety of Cosentyx in psoriasis – The Pharma Letter (registration)

Posted: July 15, 2017 at 10:44 pm

Positive five year efficacy and safety results for Cosentyx (secukinumab) from a Phase III long-term

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Post-marketing data reinforce sustained efficacy and safety of Cosentyx in psoriasis - The Pharma Letter (registration)

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The Role of Genomic Techniques in Predicting Response to Radiation Therapy – Cancer Network

Posted: at 10:44 pm

Radiation therapy (RT) remains a mainstay of modern oncologic treatment, with more than half of all patients receiving RT during their treatment course. However, individual responses to RT vary widely among disease types and patient populations.[1] Recent years have been marked by the development and expanded use of precision medicine in cancer therapeutics. Precision medicine refers to the tailoring of treatment to the individual characteristics of each patient, based on inherent susceptibilities. Although enormous strides have been made in tailoring a variety of approaches to systemic therapy, the role of radiation oncology in precision medicine is just beginning to emerge.[1]

Precision in RT has been advancing along multiple parallel paths. There have been improvements in the precision of anatomic target delineation with the use of intensity-modulated RT, volumetric arc therapy, and stereotactic RT, all of which allow for improved target dose conformality. Concurrent with technical advances in treatment delivery, the field of radiogenomics, or the interplay between genomic elements and radiation response at the cellular level, continues to evolve. Indexing the determinants of radiation response at the cellular level has the potential to allow for more personalized delivery of RT and to further increase the therapeutic ratio of our treatment.[1]

As the rates of cancer survival continue to improve, the effect of treatment toxicity on normal tissue will play an increasingly important role in treatment selection. Capturing patient-reported outcomes from the growing and evolving survivor population sheds light on the potential far-reaching impact of radiogenomics beyond traditional survival measures. Specifically, by recognizing the connection between genotypic variation and normal tissue response, our ability to predict severe toxicities following RT may spare selected individuals from significant morbidity and mortality following treatment.[2] Moreover, studies investigating genetic assays predictive of tumor radiosensitivity may be complementary to studies evaluating the radiosensitivity of noncancerous tissue.[3] The purpose of the current article is multifold: Herein, we will review the background and history of genomic predictors of RT response; evaluate candidate genes and polymorphisms dictating responses to radiation; discuss emerging data on the use of genetic signatures; and review current guidelines on the use of genomic predictors to tailor therapy. The article is structured to discuss outcomes and toxicities based on precision medicine in RT within each of these sections.

Biomarkers have long been used in the field of oncology as an adjunct to traditional staging information to estimate treatment outcomes. In this field of study, it is important to distinguish between prognostic and predictive biomarkers. Prognostic markers are associated with a clinical outcome, such as overall survival (OS), regardless of the treatment delivered.[4] For example, the prostate-specific antigen (PSA) has been proven to be an important biomarker in prostate cancer, correlating with the risk of recurrence and OS. Although elevated PSA levels are associated with worse outcomes, measurement of PSA alone does not yet predict the patient response to specific treatments.

Predictive markers, on the other hand, are indicators of the likely benefit following specific treatment. These markers are therefore useful in tailoring treatment decisions. An example of a predictive marker is ERBB2 gene amplification (resulting in overexpression of human epidermal growth factor receptor 2 [HER2]) in breast cancer, since clinical outcomes are improved by the addition of trastuzumab to the chemotherapy regimen in patients with this genetic aberration.[4] The National Comprehensive Cancer Network (NCCN), in updating the NCCN Biomarkers Compendium, recently released a task force report addressing the use of molecular biomarkers in six major disease sites.[5] While prognostic biomarkers provide important information regarding clinical outcome, implicit to the goal of precision medicine is the identification of predictive biomarkers to help direct individual treatment. Despite the significant progress made by radiogenomics in this regard over the past 20 yearsfrom focused gene studies to genome-wide association studies (GWAS)in the field of radiation oncology, clinical translation of these principles remains a goal on the horizon.[2]

Studies investigating variable responses of tissues to RT date back more than 60 years ago to the investigations carried out by Gray and colleagues.[6-8] Specifically studied was the effect of oxygenation on RT response. The tumor microenvironment has been demonstrated to have topographic variability; certain regions possess particularly low extracellular pH, low nutrient content, and hypoxia. Given the often tortuous and malformed vasculature of tumors, blood flow to the microenvironment contributes to an imbalance in the supply of and demand for oxygen. The resulting hypoxia correlates with tumor cell radioresistance, since the maximal effect of RT is achieved by the generation of free radicals.[6] Preceding the early discovery of the effect of hypoxia on radioresistance was the demonstration of individual variation in the response of normal tissue following treatment with a given dose of radiation. This was first formally described in 1936 with the publication of the now well-described sigmoid doseresponse curve.[9] Alongside the discovery of differing individual responses to similar radiation doses was the detection of RT hypersensitivity in patients with certain rare genetic syndromes. The first such documented adverse reaction occurred in a 10-year-old patient with mutation of the ATM gene, who died from complications related to radiation toxicity in normal tissues. Since this initial case was reported, the ATM mutation has been intricately linked with the DNA damage response and studied extensively.[10] While the demonstration of radiosensitivity in patients with rare genetic disorders has been instrumental in our understanding of differential radiation responses, it does not yet explain the wide range of radiation responses seen in patients without known genetic syndromes.

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The Role of Genomic Techniques in Predicting Response to Radiation Therapy - Cancer Network

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Scientists Can Now Clone Thousands of Genes in a Single Reaction – ScienceAlert

Posted: at 10:44 pm

Things are about to speed up dramatically in genetic research, with scientists developing a new technique that can clone thousands of genes in a single reaction.

The new technology, called a LASSO probe, could be used to create libraries of proteins from DNA samples, speeding up the search for new drugs by replacing the tedious methods of gene cloning currently used.

When you think of cloning you may think of Dolly the sheep or the company that promises to clone your favourite pet so you don't have to live sad and alone, but that's a different kind of cloning. Here we're talking about molecular cloning, a natural process that occurs when bacteria, insects, or plants reproduce without a partner.

Scientists clone DNA because they want to do one of two things; either they want to gain information about a particular gene or they want to manipulate genetic information in a cell to give the cell a new property. Both reasons require scientists to have millions of copies of the same DNA molecule in a test tube.

At the moment, to work out what a gene does by cloning its DNA and expressing its protein is done one gene at a time. The standard sequencing method, called molecular inversion probes, involves capturing small fragments of DNA (about 200 base pairs long) and connecting them together to map out the full genome code.

Weaving together these small sections of code to form the full gene sequence isn't easy, but there hasn't been any other way to sequence long fragments of DNA and it's been holding research back.

Not to scale. Credit: Jennifer E. Fairman/Johns Hopkins University

"We think that the rapid, affordable, and high-throughput cloning of proteins and other genetic elements will greatly accelerate biological research to discover functions of molecules encoded by genomes and match the pace at which new genome sequencing data is coming out," says one of the team, Biju Parekkadan, from Rutgers University.

In this new study, the LASSO probe - which stands for "long adaptor single stranded oligonucleotide" - can capture and clone thousands of long DNA fragments and the researchers hope that the new technique will push the limits of what we can currently do.

"Our goal is to make it cheap and easy for any researcher in any field to clone and express the entire set of proteins from any organism," said co-researcher Ben Larman from Johns Hopkins University School of Medicine. "Until now, such a prospect was only realistic for high-powered research consortia studying model organisms like fruit flies or mice."

How does this new technique work?

A collection of LASSO probes were used to grab desired DNA sequences, you can think of it like the way a rope lasso is used to capture cattle. Instead of aiming for the spiky horns of a cow, the LASSO probe targets a DNA sequence up to a few thousand base pairs long - the typical length of a gene's protein code.

The study is a proof of concept, with the LASSO probes used to capture over 3,000 DNA fragments from the E. coli bacterial genome. The results show the probes successfully captured around 75 percent of the gene they targeted.

There were also other benefits to the LASSO probe technique.

The researchers say that the sequences are captured in a way that allows them to also analyse what the genes' proteins do and demonstrated this by giving antibiotic resistance to a cell that would otherwise be killed by the antibiotic.

The researchers were also able to capture and clone a protein library from a human microbiome sample and they hope that it will lead to improved precision medicine and rapid discovery of new medicines for a range of diseases.

"We're very excited about all the potential applications for LASSO cloning," said Larman. "Our hope is that by greatly expanding the number of proteins that can be expressed and screened in parallel, the road to interesting biology and new therapeutic biomolecules will be dramatically shortened for many researchers."

The study has been published in Nature Biomedical Engineering.

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Is this politician’s comments old-fashioned funny or just plain sexist? – Starts at 60

Posted: at 10:44 pm

UK Chancellor Phillip Hammond has started a sexist storm after comments he made about driving trains.

It was a remark made in front of the whole of cabinet during the week, while discussing rail strikes, and the stranglehold unions have on picking train staff.

The Chancellor, 61, asked why it is so rare to see female train drivers, andargued that driving a modern locomotive was so simple now that even they can do it.

And yes, while a woman can do it, not many do. Of the 19,000 train drivers in Britain, only just over five per cent are female.

Read more: Donald Trump goes on sexist rant at rally.

The Sun has reported that while one MP, Jess Phillips, has told the media Hammond disgraced himself with the remark, as well as insultinghalf the countrys population, another has denied he even said it, putting the blame on another minister. However, there has been no official denial that Hammond made the comments.

Putting blame aside, the question is, is the comment insulting? If it was said in a different location, such as on a television show, would anyone even bat an eyelid, and instead laugh at the joke.

On the other hand, was he just highlighting a need for greater equality, but saying more were needed in the industry?

The rights of women have changed greatly over the years but it seems sexism is still front and centre of much of our lives. While the traditional roles of males and females has changed, attitudes towards it hasnt, but to what effect. The once appreciated wolf-whistle is frowned upon, you cant ask someone if they have children without thoughts of discrimination, and even a list of best dressed isconsidered sexist.

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Is this politician's comments old-fashioned funny or just plain sexist? - Starts at 60

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Letter: The absurdity of political correctness – Lima Ohio

Posted: at 10:44 pm

Apparently, one of the things conservatives like about Donald Trump is his propensity to be politically incorrect. I do believe that as a society we have become overly obsessed with political correctness. For example, why get bent out of shape if someone says Merry Christmas? Does it really matter if a Native American is referred to as an Indian? Islamic terrorism is a real thing, so why bother to deny it.

People often engage in linguistic gymnastics so as not to be offensive and that is what I consider to be the absurdity of political correctness.

Having said this, I think it is important to make a distinction between being political incorrect and just plain bad manners and vulgar behavior. If we are looking to a time in our history when people were less politically correct, it is important to remember that plain, blunt language doesnt need to be vulgar.

When was it ever OK to make fun of a womans physical appearance and refer to her as a fat pig? When was it ever acceptable to mock someone who suffers from a physical disability and put them into a position of public derision? When was it ever proper to imply that a judge could not render an impartial decision because of his ethnicity? When you mock and ridicule people on a personal level you arent being politically incorrect, you are being vulgar and indecent. There is a difference and it is important to recognize the distinction.

James Carr, Celina

.

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Letter: The absurdity of political correctness - Lima Ohio

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Church condemns police brutality – DailyNews

Posted: at 10:44 pm

staff writer 15 July 2017 5:27PM 0 comments

HARARE - The Church has condemned the police for its use of force in crushing Wednesdays demonstration by the MDC youths describing its heavy-handedness as irrational and bad for upholding national peace and democracy at large.

Zimbabwe Divine Destiny (ZDD) leader Bishop Ancelimo Magaya had no kind words for the police and labelled Wednesdays behaviour as barbaric and an act of repression.

What is wrong with citizens expressing their democratic rights by making their demands on an election issue?

Where else can they express displeasure on electoral issues? This matter is beyond the police, they have nothing to do with Zimbabwe Electoral Commission (Zec) and political parties, they should have just let people demonstrate, does that harm anyone? Magaya asked rhetorically.

As matters stand, police are now the instigators of violence and not enforcers of law because the demonstrators were within their constitutional rights to demonstrate and the police failed in their duty to protect these citizens.

On Wednesday, MDC youths staged a demonstration against Zec demanding that the national elections management body introduce electoral reforms ahead of next years elections.

Heavily-armed police crushed the demo by beating protesters and ordinary people going about their business before indiscriminately firing tear gas and using water cannons to clear the city.

Police spokesperson Charity Charamba had told the Daily News that they had not okayed the demo.

The response by the police spokesperson that ZRP had not cleared the demonstration is an age-old flimsy excuse.

Police should always be impartial but we have witnessed demonstrations by disgruntled Zanu PF members proceed unperturbed, even where clashes between rival factions were imminent. It is now clear that there is one law for the rest of the nation and another special one for those deemed to be pro the ruling party and this is unacceptable.

In the same breadth an opposition members car was burnt in Kuwadzana and the police do not seem to have appetite to investigate nor descend with similar gusto on such because the victim is politically incorrect in their view. What a shame! Magaya said.

Charamba told State media that police investigations were underway to establish how the MDC car was torched.

Two unknown people were seen at a car park at Kuwadzana Shopping Centre and immediately after they left the security guard saw the car, an Isuzu single cab; white in colour registration number ADA 1562, catch fire.

A report was made at ZRP Kuwadzana and police attended the scene and called the Fire Brigade but the vehicle had already been damaged. The value of the car is $10 000.

After investigations we will be in the position to ascertain the perpetrators and the motive, said Charamba.

Zanu PF secretary for administration Ignatius Chombo, who is also the Home Affairs minister, said it was an inside job.

I really think it was an inside job to get attention and a trick by a fracturing party that is facing loss in the next elections, said Chombo.

Magaya said the Church had a duty to promote peace and condemn violence.

The Church cannot keep quiet when citizens lives are put at risk and threatened by none other than the State police. It is for the same reason that the Church launched a Christian Vote campaign last month and amongst the values we are rooting for is, non-violence.

We need to exorcise this demon of bloodletting and violence and realise politics can be clean and progressive as opposed to what some of our liberators would have us believe.

When will this nation, its people particularly, enjoy peace to vote freely, to ask complain or even demonstrate on anything irregular without being vilified? asked Magaya.

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ACLU may sue over censorship of social media pages by elected officials – Gardnernews.com

Posted: at 10:43 pm

An ACLU letter sent to Kansas Senator Mary Pilcher-Cook, 10th District, has resonated with at least one Gardner resident. Wes Rains, Gardner, recently sent a letter to Lee Moore, Gardner councilman, requesting Moore unblock his ability to post to Moores official city councilmans Facebook page.

Lee Moore

Recently, a more famous public official (state Senator) has practiced the same form of censorship that you have, and she now has been asked by the ACLU to cease this behavior, Rains said in his e-mail. I believe this to be a similar situation, and am considering writing to the ACLU myself to appeal to your better nature and judgement, but before I do that, I am asking you myself as a Gardner citizen and constituent and voter. Rains attached the American Civil Liberties Union July 5, 2017, letter to Sen. Pilcher Cook in his email to Moore. According to the ACLUs letter, blocking opposing views violates citizens well established First Amendment rights to criticize elected officials and express opinions of public concern. Censoring a constituents viewpoint violates the First Amendments Speech Clause. According to Moores response received by Rains and supplied to The Gardner News, I am not required by ordinance or by statute to maintain an official Facebook page. Therefore, my social media activity, all of it, is a completely private endeavor. In fact, all of the content I place on my page, is licensed to Facebook by virtue of the EULA they make you sign when you create the account. In fact, because they own the platform, they may even elect to censor me, should they so desire. So, to make the argument that I can somehow violate your First Amendment rights from within a platform that I do not own or otherwise have any authority over, beyond that licensed to me by the owner of the platform, and that I am not even legally obligated to use for official business is absolutely laughable. I mean, what are you going to do if Facebook bans you for violating their terms of service? Will you claim that is also a violation of your First Amendment right? Thanks for the laugh. You may engage with me anywhere you find me in public, over the phone, and through my official email just like constituents who have no access to Facebook. You may also share content from my page on CFG and engage me there. Until I am required by statute to maintain an official public social media presence, I will reserve the right to control the content associated with my name. That said, I think you were banned only because you were backing the opposition and got obnoxious with me when I was running for office and this page was servingas my campaign page. However, I checked and you are not even banned and have not been banned for a very long time. If I do ban you in the future, maybe all it takes is asking me nicely instead of threatening me. Enjoy your weekend. Cheers, Lee According to Doug Bonney, Kansas legal director for the ACLU, Social media has become an essential tool of communications between elected officials and their constituents, and blocking someone from an officials Facebook page violates the First Amendment and the well-established right of the public to criticize elected officials. On July 5, we sent a letter to Senator Pilcher-Cook outlining these concerns and requesting that she cease censoring the comments on her page and reinstate those who have been blocked. In an e mail to The Gardner News, Moore said there was not anyone currently blocked on his social media page, although he admits Rains was temporarily blocked during Moores election campaign two years ago. He also says he is unclear when Rains was unblocked. Nobody is currently blocked from posting comments on the Lee Moore Gardner City Councilman Facebook page, Moore wrote. However, he indicates that he reserves the right to limit abusive or harassing language and makes note that the social media platform is not required nor government owned. Moore says he will not be bullied, but that he will not try to use his Facebok page to silence opposing opinions. Thus, Mr. Rains email to me and the rest of the Governing Body was received by me as an ignorant, ill-conceived, and unprovoked threat, he writes. Although, the ACLU is an organization which holds no authority over me or the City of Gardner. Nevertheless, I will not be bullied. Likewise, I cannot and will not try to use my Facebook page as a tool to silence people who hold opposing opinions. However, I will also not tolerate comments from people who are unable or unwilling to maintain civility and basic relevance to the topic being discussed. The complete text of his response is adjacent to this story. Since the ACLUs letter was sent, it appears the problem with censorship is more widespread than originally thought, said Bonney, ACLU. Theres a lot more of this than I realized, he said. The core first amendment right is to speak and be heard by your elected officials, Bonney continued. When elected officials censor those voices, they are violating the First Amendments core principle. If elected officials dont voluntarily comply by allowing constituents to comment, Bonney said other options will be considered. We will evaluate our options, Bonney said. At this point, there are no individual lawsuits anticipated, but it may become necessary to file a lawsuit. ACLUs around the country are looking at this, Bonney said. Currently, there is at least one ACLU branch preparing a lawsuit. The American Civil Liberties Unions website says, Last month, we were contacted by a constituent of the 10th District of Kansas who had been blocked from the official Facebook page of Senator Mary Pilcher-Cook, the state senator representing her district. The constituent was blocked after leaving comments on the page expressing opposition to the policy stances taken by Senator Pilcher-Cook, which were also subsequently deleted. The ACLUs letter to Pilcher-Cook is available online at: https://www.aclukansas.org/en/news/aclu-letter-senator-pilcher-cook-regarding-facebook-page-censorship As of July 11, Rains said his posts to Moores page were still blocked.

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China’s newest censorship methods on display – IFEX

Posted: at 10:43 pm

This statement was originally published on freedomhouse.org on 13 July 2017.

Sarah Cook, Senior Research Analyst for East Asia

July, more than most other months, is loaded with politically sensitive anniversaries that keep Communist Party of China (CPC) censors and security forces on their toes.

First comes the July 1 anniversary of Hong Kong's transfer from British to Chinese rule. Then there is July 5, marking the 2009 ethnic violence in the Xinjiang region that sparked an unprecedented crackdown on its mostly Muslim Uyghur population. The very next day, July 6, is the Dalai Lama's birthday, and July 9 is the second anniversary of a sweeping repressive action against China's human rights lawyers. Finally there is July 20, the date in 1999 when the CPC banned the popular spiritual practice Falun Gong and began a massive - and often violent - campaign to eradicate it.

This year, the anniversaries overlap with other news stories that Beijing likely wants to quash, including an international uproar surrounding democracy activist Liu Xiaobo's belated release on medical parole with terminal cancer, and a campaign by exiled tycoon Guo Wengui to publicize corruption allegations involving top Chinese leaders.

It is not surprising in these circumstances that the CPC has tightened information controls. But the party has not simply intensified its efforts in the short term. It has also gradually adapted its methods to a changing technological environment, one in which mobile phones, social media applications, and digital surveillance are critical features.

The result is a new level of intrusiveness and sophistication, as well as danger for populations that are already at risk of severe human rights violations.

One of the escalating restrictions that may have the widest reach is a crackdown on virtual private networks (VPNs), which allow users to bypass official censorship. Several VPN applications have been disabled or removed from online stores since July 1. In a June 22 message to customers, prominent VPN provider Green said that after receiving "a notice from the higher authorities," it planned to cease operations on July 1, causing a ripple of conversations on social media about what circumvention tools could still be used. The latest initiative builds on increasing official efforts to stop the dissemination of such tools, including some that the authorities had long tolerated.

The applications' removal will have the secondary effect of cutting off software updates for users, leaving their devices more vulnerable to hacking. And while many use VPNs to access uncensored news or blocked social media sites like Facebook and Twitter, the tools are also used for security purposes, to protect businesses and activists from pervasive state surveillance.

Other recent controls have focused on ethnic and religious minorities. In Xinjiang, authorities in a district of the regional capital Urumqi issued a notice on June 27 instructing all residents and business owners to submit their "personal ID cards, cell phones, external drives, portable hard drives, notebook computers, and media storage cards" to the local police post for "registration and scanning" by August 1. One district employee told Radio Free Asia that the campaign was taking place throughout the city. The goal is ostensibly to identify and purge any "terrorist videos," but the action violates the privacy rights of Urumqi's three million residents and exposes them to punishment for a host of other possible offenses, including those related to peaceful religious or political expression.

In Tibet, the instant-messaging application WeChat has become increasingly popular in recent years, as it has across China. But using it to communicate about the Dalai Lama or his birthday is difficult and dangerous. A test conducted in January by the Canada-based Citizen Lab found that the Tibetan spelling for "Dalai Lama" was automatically deleted in WeChat messages. Meanwhile, at least two Tibetans are known to have been jailed for participating in a WeChat group commemorating the spiritual leader's 80th birthday in 2015. After a new spate of self-immolation protests took place in early 2017, Tibetans in Sichuan Province report that police are monitoring communication on the platform more closely and detaining those suspected of sharing information about self-immolations with overseas contacts.

These developments reflect a broader trend identified in a recent Freedom House report on religion in China. The study found that Chinese government tactics of religious control and persecution have been changing to incorporate new technologies and match the evolving communication habits of the public. Even in the absence of sensitive anniversaries, various modes of electronic surveillance have expanded dramatically at sites of worship and public spaces frequented by religious believers.

The CPC's information controls also appear to be spreading to traditionally less persecuted groups, like state-sanctioned churches and non-Uyghur residents of Xinjiang. Since March, authorities in Zhejiang have reportedly been implementing a campaign to install surveillance cameras in churches and possibly Buddhist temples, in some cases sparking altercations with police and violence against congregants. In Urumqi, the order to turn in digital devices for inspection applies to ethnic Han and Kazakh residents as well as Uyghurs, while local Kazakhs have reported increased monitoring and some prosecutions related to expressions of their Muslim faith in recent months.

The Chinese government's actions are partly a response to creative initiatives by minority activists to share their stories and perspectives in a heavily restrictive information environment.

"It is a nonstop game of cat-and-mouse," journalist Nithin Coca wrote in a June 27 article about China's high-tech war on Tibetan communication. "As the Tibet movement's digital-security abilities and training improve, the Chinese government implements more sophisticated hacking techniques."

Similarly, as Falun Gong practitioners devise new means of disseminating information to debunk vilifying state propaganda and expose abuses they have suffered, security forces have adapted by increasing electronic surveillance and deploying geolocation technology to find and arrest them. Local authorities in places like Jiangsu province have also upgraded anti-Falun Gong propaganda efforts, deploying LED rolling screens, cartoons, microblogs, and QQ messaging - including in schools - last month to demonize Falun Gong and other banned religious groups.

The result of the escalating controls is that there are even fewer avenues for persecuted groups and individuals to defend themselves, offer alternatives to the party line, or expose violence committed by officials. Meanwhile, other Chinese interested in knowing more about these and other censored topics find it increasingly difficult - and risky - to obtain information.

There is also a cost to the CPC. Such aggressive "stability maintenance" methods ultimately increase tensions with key populations, intensify resentment of the party's heavy-handed rule, and inspire anti-government activism and even violence, including among otherwise apolitical citizens.

From that perspective, while the CPC's efforts may successfully silence some critics this year, party leaders may face an even more daunting challenge next July.

This article was also published in the Diplomat on July 7, 2017.

Sarah Cook is a senior research analyst for East Asia at Freedom House, director of its China Media Bulletin, and author of "The Battle for China's Spirit: Religious Revival, Repression, and Resistance under Xi Jinping".

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Why censor body should not be deciding the films you should watch and the words you should hear in them – Economic Times

Posted: at 10:43 pm

For filmmaker and professor of economics Suman Ghosh, the irony is difficult to miss. His 2011 Bengali feature film Nobel Chor , which was inspired by the theft of Rabindranath Tagores Nobel medal and became a politically controversial topic in Bengal, was cleared by the Central Board of Film Certification (CBFC). Four years later Kadambari , a biopic based on Tagores special relationship with his sister-in-law, also got the CBFCs nod. Why then is his most recent venture, The Argumentative Indian , a one-hour documentary on economist and Nobel laureate Amartya Sen, facing the heat from the governments censorship body?

Ghosh has been asked to mute out four words/phrases Gujarat, Hindutva view of India, cow and Hindu India to get a goahead from the CBFC. The words in question are not part of the directors script but figure in Sens opinion in the course of a conversation with Kaushik Basu, a fellow economist and former chief economic advisor of the government of India. The documentary, which has been screened once in Kolkata for a select audience, was to be released this week, when it was stalled by the Kolkata office of the censor board. He has uploaded a trailer on Facebook.

Im still in a state of shock and trying to figure out what to do next so that film can be screened without beeping out the words, says the award-winning filmmaker whose first feature film Poddokkhep in 2006 won two national awards, including best actor for Bengali thespian Soumitra Chatterjee. Ghosh, a professor of economics at Florida Atlantic University, will be in India for another month because he has just started shooting for his next film, Basu Paribar , with Chatterjee and Aparna Sen. He hopes that he will be able to sort things out and The Argumentative Indian will be released before he goes back to the US.

The disturbing trend of arbitrarily curbing creative freedom of film directors started with Abhishek Chaubeys Udta Punjab , during the tenure of CBFC chairman Pahlaj Nihalani, who took charge in early 2015. More recently, the CBFC refused a release certificate to Lipstick Under My Burkha . And now I feel that the fact that Amartya Sen has been critical of the BJP government may be one of the reasons for the curbs on my film, Ghosh told ET Magazine over phone from Kolkata. He feels that the Bollywood film fraternity, along with their counterparts from regional cinema in India, should come together and raise their voices against the censor board to ensure that directors freedom of expression is not attacked.

Setting Limitations Ghosh is not the only filmmaker having problems with censorship. Madhur Bhandarkars much awaited Indu Sarkar , which is based on the Emergency period in India and scheduled for release this month, has run into rough weather with the CBFC having demanded 14 cuts. The things that CBFC is asking us to change will change the essence of the film. We would surely go to the Revising Committee or the Tribunal if need be, the director said in reply to ET Magazine s questions on email. The Revising Committee is the second panel with a different set of members from the Examining Committee (the first panel). The final panel is the Film Certificate Appellate Tribunal (FCAT), which usually comprises retired judges and senior industry members. There is nothing derogatory in the film and all the names that we are using have been used for many documentaries, books and have been reported in the public domain. Also, the film is a human drama; the Emergency is just the backdrop, Bhandarkar added. I would request people to let the film release, see it in totality and then judge. Asking for ban, burning effigies or asking people to blacken my face is not the way.

Lipstick Under my Burkha , which was grounded by the CBFC last October because of its lady-oriented content, is now scheduled for a release next week after the FCAT overturned the CFBC ruling. Director Alankrita Shrivastava feels that in a democratic country, the censor body should have no role to play beyond a basic certification of films. Citizens have a right to engage with and consume whatever content they want to and the censor authorities should not come with any moral baggage, says Shrivastava. Now that her film, which went on to win several international awards, has been cleared with an A certificate, she is relieved. Not allowing the film to be released in India at all would have created a wrong precedent, discouraged women directors and been a step against artistic freedom, she says.

Filmmaker Onir, whose Shab was released on Friday, says there is an urgent need to revise film censorship guidelines. The Cinematograph Act is completely illogical in the present context. We should only follow a basic certification system in keeping with the principles of freedom of creative expresssion, the director said, adding that he was fortunate that his new film, which is about relationships and set in Delhi, was cleared with an A certificate, without any visual cuts and he had to only mute four words.

Director Prakash Jha, who is also the producer of Lipstick has long called for the scrapping of the censor body for films in India and feels that only basic certification guidelines should be followed. If you give anyone the authority to decide what other people will watch, they will look at it from their own perspective which will be determined by upbringing, education and other factors. No one should be given such authority and an authoritarian mindset can only harm creative expression and freedom of film directors. I have always said this and continue to say it, Jha told ET Magazine. While he was expecting Lipstick to run into problems with the censor board, he was surprised that the body completely refused to release the film.

There was no response to an email with questions sent to the CBFC chairperson at the time of writing. The problem may not be only with CBFC, points out Mumbai-based film and TV editor Irene Dhar Malik. The I&B ministry too recently didnt grant screening certificates to three documentaries that were selected for the International Documentary and Short Film Festival of Kerala they were on Rohit Vermula, JNU & Kashmir.

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Why censor body should not be deciding the films you should watch and the words you should hear in them - Economic Times

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China’s artists defy censorship ban to mourn Liu Xiaobo – Art Newspaper

Posted: at 10:43 pm

The death on Thursday of Chinese dissident activist and Nobel laureate Liu Xiaobo elicited an outpouring of grief and anger in China, particularly from its artists. Though usually preferring to remain safely apolitical, members of the Chinese art world defied a ban on covering or mentioning Liu and expressed their sorrow and frustration at his death through mostly indirect references on Chinese social media.

Ai Weiwei, the Chinese dissident artist now living in Berlin, told the BBC yesterday: "It still comes as a big shock... because he has been such a symbol for China's human rights or democratic movement." Ai said of his friend, "I think Liu Xiaobo will be remembered as an individual, a strong mind, with his belief, and as a brave fighter, believing in democracy and freedom of speech. And he sacrificed his life for his belief."

His compatriots still based in China, though unable to speak so freely, found creative ways to mourn Liu on the social media platform Wechat. According to some reports, the national outpouring was so widespread that the government banned the emojis for candles and clasped hands on Twitter clone Weibo, though they remain permitted on Wechat.

Articles mentioning Liu's death, with titles like "The Death of Freedom", were quickly expunged, but artists and curatorshave instead posted screenshots of the error message, with comments like, "Do you not understand what bullshit this is!" Screengrabs of global media reports were also popular, as technology currently does not facilitate the searching of textual images.

One artist listed the characters of Liu Xiaobo's name but on different lines, slowing their removal. Many posted simple all black or grey squares were posted to represent censorship, sometimes adding the prayer and candle emojis and references like Liu's age of death, 62, or simple expressions of gratitude.

Some posted the works of Liu Xiaobo's poet and artist widow Liu Xia, who remains under house arrest, depicting mutilated dolls positioned in bleak landscapes. Paintings of empty chairsreferencedthe empty seat at Liu Xiaobo's 2010 ceremony for the Nobel Peace Prize, which the Chinese government refused to release him to receive.

Liu Xiaobo was a professor spurred to activism by the Tiananmen Square protests of 1989, and negotiated the safe passage of hundreds of students from the square. In and out of prison since for his fearless criticism of the government, he was last sentenced to 11 years in 2009 for co-authoring Charter 08, a 2008 call for political reform and greater freedom.

Officials announced Liu's terminal liver cancer last month, and moved him to a hospital in Shenyang under high security but refused to release him for treatment abroad. And while his name can be erased from China's public domain, his memory remains powerfully present.

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China's artists defy censorship ban to mourn Liu Xiaobo - Art Newspaper

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