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Category Archives: Transhuman News
China unveils gene technology to create SUPERHUMANS with hyper-muscular test-tube dogs – Express.co.uk
Posted: July 17, 2017 at 3:46 am
The dogs, which are test tube bred in a lab, have twice the muscle mass of their natural counterparts and are considerably stronger and faster.
The canine genome has been especially difficult to engineer and replicate but its close similarity to the human genome means it has long been the prize of geneticists.
Now the Chinese success has led to fears the same technology could be used to create weaponised super-humans - typifed in Marvel Comics by Captain America and his foes.
MARVELEYEVINE
David King, director of Human Genetics Alert (HGA), voiced his fears over what is widely viewed as the first step on a slippery slope.
He told express.co.uk: Its true that the more and more animals that are genetically engineered using these techniques brings us closer to the possibility of genetic engineering of humans.
Dogs as a species, in respect of cloning are very difficult, and even more difficult to clone human beings.
Theres no medical case for it, the scientists are interested in being the first person in the world to create a genetically engineer child.
In terms of genetic engineering we will be seeing this more and more
David King, director of Human Genetics Alert
Theyre interested in science and the technology and their careers. They will continue pushing the regulations for it.
That does set us on the road to eugenics. I am very concerned with what Im seeing.
An army of super-humans has been a staple of science fiction and superhero comics for decades but the super-dog technology brings it closer to reality.
The Chinese researchers first self-bred cloned dog was named Little Long Long.
SINO GENE
The beagle puppy, one of 27, was genetically engineered by deleting a gene called myostatin, giving it double the muscle mass of a normal beagle.
The advance genetic editing technology has been touted as a breakthrough which could herald the dawn of superbreeds, which could be stronger, faster, better at running and hunting.
The Chinese official line is that the dogs could potentially be deployed to frontline service to assist police officers.
Dr Lai Liangxue, researcher at Guangzhou institute of biological medicine and health, said: "This is a breakthrough, marking China as only the second country in the world to independently master dog-somatic clone technology, after South Korea."
VCG via Getty Images
1 of 23
Armed police soldiers lift timbers during a drill on August 24, 2016 in Chongqing, China. As the highest temperatures reached over 40 degree Celsius at 5 districts in Chongqing, officers and soldiers of an armed police crop took outdoor training
Some 65 embryos were edited, and from that 27 were born, with Little Long Long the only one who was created without the myostatin gene. Myostatin is known to control muscle size in humans.
Dogs are one of the hardest animals to clone, with only South Korea thought to have successfully created a clone in the past.
As well as the enhancements, researchers said in the Journal of Molecular Cell Biology some dogs will be bred with DNA mutations in a bid to help medical research, including some which mimic Parkinsons.
Dr Lai added: "The goal of the research is to explore an approach to the generation of the new disease dog models for biomedical research.
GETTY
"Dogs are very close to humans in terms of metabolic, physiological and anatomical characteristics."
But some have criticised the experiments, citing ethical concerns.
Mr King said: This is the way its likely to proceed if the law is changed, first of all they will use it for medical purposes, most likely to treat a genetic condition.
In terms of genetic engineering we will be seeing this more and more.
There are also fears that, as well as medical, tinkering with genetics could also lead to a rise in designer or novelty pets.
Dr Lai said his team have no intentions to breed the bulked up beagles as pets.
But Mr King also voiced fears that this breakthrough, coupled with existing cases of altering human embryos, could lead to further calls for designer babies.
The director of HGA, and independent body, claimed there are multiple examples of eugenics going on already, citing women who are intelligent and beautiful are paid more for their eggs in the US.
Mr King said: Its not scaremongering.
Im seeing the beginning of a campaign within the scientific community to legalise human genetic engineering.
Weve seen how it happened with the thee-parent embryo.
SINO GENE
I can see the same thing building up with genetic engineering.
There are strict laws around cloning, but one example of a case in the UK is Dolly the sheep.
Born in 1996, she died aged six in 2003, half the normal life span of a Finn Dorset sheep.
And recently, an artificial womb for premature babies was tested on lambs, and showed significant success.
Lambs born at the equivalent of 23 weeks were placed inside the fake womb which contained fluid mimicking that found in an amniotic sac.
They remained inside for 28 days, and continued to develop, even growing white fleeces.
Guo Longpeng, the China press officer for the Asia division of People for the Ethical Treatment of Animals, said: "Cloning is unethical.
"Like any other laboratory animal, these animals are caged and manipulated in order to provide a lucrative bottom line."
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Oklahoma medical briefs, July 16 – NewsOK.com
Posted: at 3:46 am
From Staff Reports Published: July 16, 2017 5:00 AM CDT Updated: July 16, 2017 5:00 AM CDT
John Mulvihill, M.D., at The Children's Hospital at OU Medical Center, has won a mentorship award from theAmerican Society of Human Genetics. [Photo provided]
Geneticist wins national recognition
John Mulvihill, an geneticist at The Children's Hospital at OU Medical Center, has been awarded the American Society of Human Genetics mentorship award. The award recognizes those with records of accomplishments as mentors. He will receive the $10,000 award at the national group's annual meeting on Oct. 20 in Orlando, Florida.
Back-to-school shots available
The Oklahoma City-County Health Department is offering back-to-school immunizations for students at three locations across Oklahoma City. Immunizations will be offered Monday through Thursday from 8 a.m. to 4 p.m. and 8 a.m. to noon on Friday. A copy of the students immunization records is required. Immunization services will be offered at:
Gary Cox Partner Building, 2700 NE 63
South Wellness Campus, 2149 SW 59, Suite 104
West Clinic, 4330 NW 10
Birth certificates needed for school
The Oklahoma State Department of Health is urging families to begin requesting birth certificates as they prepare to send their children back to school. The busiest month of the year for requests is August and long lines are normal. The cost is $15 for a copy. Information can be found online at http://vr.health.ok.gov.
Mumps still a problem in state
Kristy Bradley, state epidemiologist, confirmed that the state is still facing a problem with mumps. Oklahoma and Garfield counties are still seeing cases of mumps transmission. The state has had 152 cases since January.
From staff reports
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Oklahoma medical briefs, July 16 - NewsOK.com
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Families Of Missing People Seek Closure At DNA Collection … – CBS Minnesota / WCCO
Posted: at 3:46 am
July 15, 2017 10:19 PM
MINNEAPOLIS (WCCO) Families of the missing are trying to seek closure for their loved ones.
The Minnesota Bureau of Criminal Apprehension held a DNA collection opportunity for nine people who are missing a family member. People had the opportunity to provide a DNA sample to be compared with people in the national missing persons database.
Annie Montgomery and Percy McGee are the mother and brother of Shirley McGee, who went missing in Chicago in 1973.
Diane McCarthy is the sister of Mary Louise Ronning, who went missing from Minneapolis in 1979.
The BCA says there are 100 unidentified remains in Minnesota, 550 people missing at any time in the state and about 11,000 people reported missing every single year.
The BCA believes remains from five unknown people exhumed last year in Minnesota have a strong chance of being identified through their DNA profiles. But, they need families with missing loved ones to come forward to find a match.
There will be more collection opportunities this month across the state.
For more information, you can go to our website, click here.
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WVGS to host program July 25 on DNA testing – Brazil Times
Posted: at 3:46 am
Genealogy and genetics have become interconnected. DNA can provide insight into your family heritage that cannot be obtained from genealogy research alone. But how do people go about finding out what information is found in their DNA.
On Tuesday, July 25, the Wabash Valley Genealogy Society will offer a free, public program which can help you better understand DNA testing and what is involved in deciphering some of the intriguing family connections found through DNA matches.
The program is titled Which DNA Test is Right For Me. The presenter for this program will be Tim Phipps, president of the WVGS and acknowledged DNA expert as it relates to genealogy and family history.
The program will be in the lower level conference rooms at the Vigo County Public Library in Terre Haute. The doors open at 6 p.m. with the presentation running from 6:30 to 8:30 p.m.
Anyone with questions about this or other WVGS programs can find additional information on the WVGS website: http://www.inwvgs.org.
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WVGS to host program July 25 on DNA testing - Brazil Times
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How accurate are DNA tests from websites that trace your heritage? – AOL
Posted: at 3:46 am
DALLAS (KDAF) -- We've all seen the commercials, but if you're thinking of sending out your DNA to trace your heritage, you might want to think again.
Yeah - it turns out those DNA testing sites that are supposed to help you discover your ancestry are not as accurate as you'd think.
RELATED: DNA test helps reunite mom, daughter after 50 years
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DNA test helps reunite mom, daughter after 50 years
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A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
A woman was reunited with her birth mother 50 years after she was adopted thanks to a DNA test that revealed they had both been searching for each other.
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SHOW CAPTION
Anthropologist Dr. Jonathan Marks joined Morning Dose, Tuesday via-Skye, and he says they're about as accurate as looking in the mirror.
"It's just not your grandfather's science. And what I mean by that is that it's so explicitly labeled as recreational science. It's a way of saying to customers that this result has no legal or scientific standing," Marks said.
At the end of the day, it all depends on what you expect to get out of it. He says it could certainly help reunite you with a long-lost relative, which could be valuable to you.
"You're getting something that's fun, but it's probably not going to tell you, as I said before, any more about yourself, sort of racially, than you can see looking in the mirror," Marks said.
In other words, you might just want to save your time and money.
More from AOL.com: These genetically-modified dragonflies could be used for spying one day Scientists may finally know why these magnificent corals glow in the dark Here's how your Fourth of July fireworks work
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Study Indicates 75% of Human Genome is Non-functional – Technology Networks
Posted: at 3:45 am
An evolutionary biologist at the University of Houston has published new calculations that indicate no more than 25 percent of the human genome is functional. That is in stark contrast to suggestions by scientists with the ENCODE project that as much as 80 percent of the genome is functional.
In work published online in Genome Biology and Evolution, Dan Graur reports the functional portion of the human genome probably falls between 10 percent and 15 percent, with an upper limit of 25 percent. The rest is so-called junk DNA, or useless but harmless DNA.
Graur, John and Rebecca Moores Professor of Biology and Biochemistry at UH, took a deceptively simple approach to determining how much of the genome is functional, using the deleterious mutation rate that is, the rate at which harmful mutations occur and the replacement fertility rate.
Both genome size and the rate of deleterious mutations in functional parts of the genome have previously been determined, and historical data documents human population levels. With that information, Graur developed a model to calculate the decrease in reproductive success induced by harmful mutations, known as the mutational load, in relation to the portion of the genome that is functional.
The functional portion of the genome is described as that which has a selected-effect function, that is, a function that arose through and is maintained by natural selection. Protein-coding genes, RNA-specifying genes and DNA receptors are examples of selected-effect functions. In his model, only functional portions of the genome can be damaged by deleterious mutations; mutations in nonfunctional portions are neutral since functionless parts can be neither damaged nor improved.
Because of deleterious mutations, each couple in each generation must produce slightly more children than two to maintain a constant population size. Over the past 200,000 years, replacement-level fertility rates have ranged from 2.1 to 3.0 children per couple, he said, noting that global population remained remarkably stable until the beginning of the 19th century, when decreased mortality in newborns resulted in fertility rates exceeding replacement levels.
If 80 percent of the genome were functional, unrealistically high birth rates would be required to sustain the population even if the deleterious mutation rate were at the low end of estimates, Graur found.
For 80 percent of the human genome to be functional, each couple in the world would have to beget on average 15 children and all but two would have to die or fail to reproduce, he wrote. If we use the upper bound for the deleterious mutation rate (2 108 mutations per nucleotide per generation), then the number of children that each couple would have to have to maintain a constant population size would exceed the number of stars in the visible universe by ten orders of magnitude.
In 2012, the Encyclopedia of DNA Elements (ENCODE) announced that 80 percent of the genome had a biochemical function. Graur said this new study not only puts these claims to rest but hopefully will help to refocus the science of human genomics.
We need to know the functional fraction of the human genome in order to focus biomedical research on the parts that can be used to prevent and cure disease, he said. There is no need to sequence everything under the sun. We need only to sequence the sections we know are functional.
This article has been republished frommaterialsprovided by The University of Houston. Note: material may have been edited for length and content. For further information, please contact the cited source.
Reference
Graur, D. (2017). An upper limit on the functional fraction of the human genome. Genome Biology and Evolution.
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A Living Hard Drive: This GIF Was Stored in the DNA of Bacteria – Singularity Hub
Posted: at 3:45 am
DNA is a hugely promising medium for storing data. Consider that a cell nucleus can hold the instructions for an organism as complex as a human. So far efforts to store non-genetic data in DNA have been carried out in test tubes, but now scientists have encoded a GIF into the genome of living bacteria.
The scientists from Harvard University used the CRISPR genome-editing tool to store a picture of a hand and an animation of a running horse adapted from Eadweard Muybridges 1878 photographic study Human and Animal Locomotion in the genome of E. coli bacteria.
More importantly, they were able to retrieve the image of the hand perfectly and the GIF with 90 percent accuracy by sequencing the bacterial genomes. Their results were published in the journal Nature on Wednesday.
Efforts to store unconventional data in DNA have been going on for years thanks to DNAs incredible compactness and long shelf life. Properly stored, it can keep data intact for at least 100,000 years. Just a couple of months ago Microsoft said it planned to incorporate a DNA storage system in one of its data centers by the end of the decade.
Typically, though, this has been done by translating the bits that encode books, images or audio recordings into DNA sequences and then synthesizing them artificially. By using CRISPR instead, the Harvard team, led by renowned geneticist George Church, was able to hijack the genomes of E. coli bacteria to store the information.
The CRISPR system is actually a natural defense mechanism that bacteria use to develop immunity to invading viruses by recording snippets of the attackers DNA in the bacterias genome. These snippets are then used to guide the enzyme Cas9 to find and destroy invasive DNA next time the virus attacks.
The CRISPR/Cas9 system has been re-purposed by scientists to edit genomes by re-engineering it so it chops DNA sequences at a specific location. This then allows them to remove existing genes or add new ones.
In this new study, though, the researchers instead re-purposed the lesser-known Cas1 and Cas2 proteins responsible for inserting viral DNA into the bacterias genome. We found that if we made the sequences we supplied look like what the system usually grabs from viruses, it would take what we give, Seth Shipman, a neuroscience researcher at Harvard and study co-author, told The Verge.
Importantly, Cas1 and Cas2 insert new pieces of DNA in the order they arrive, which is what made it possible for the researchers to encode an animation. The data was actually encoded in 600,000 cells to help boost accuracy because the process is not precise, but modern sequencing tools mean its fairly quick to retrieve the data.
The amount of data stored in the cells is considerably less than whats been achieved with the synthesis route. Last year researchers from Microsoft and the University of Washington stored 200 megabytes of data in a smear of DNA smaller than a pencil tip.
That means the approach is unlikely to supplant synthesized DNA for the kind of long-term data storage that has piqued the interest of IT firms. But the ability to record data directly into a cells genome does open up a host of new potential applications.
The one the researchers themselves are most interested in is the prospect of turning cells into recording devices that can track changes in both their internal workings and their environment over time. They think this could help us to understand the developmental processes that govern how neurons morph into specialized cells over time or help track which neurons are talking to each other.
Further into the future, it may be possible to effectively create black boxes for cells in the human body, Church told The New York Times. Bacteria could be made to record the activity of cells over time, and when someone gets ill doctors could extract the bacteria and sequence their DNA to play it back.
Its also possible to imagine the approach could be a useful new tool for synthetic biologists who are already using gene circuits to build tiny computers inside cells that can carry out logic functions by providing a form of memory.
Banner Image Credit:Eadweard Muybridge/Wikimedia Commons
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Bob Wolff, Hall of Fame sportscaster of astonishing longevity, dies at 96, – Washington Post
Posted: at 3:45 am
By Bob Levey By Bob Levey July 16 at 7:42 PM
Bob Wolff, a Hall of Fame sportscaster who spent more than 75 years as the voice of professional athletic events and who served as the first TV announcer for the Washington Senators, died July 15 at his home in South Nyack, N.Y. He was 96.
The cause was not yet known, but Mr. Wolff had been recovering from a cold, said his son Rick Wolff.
Guinness World Records certified in 2012 that Mr. Wolff, whose career began on CBS Radio in 1939 and continued through recent years on Cablevisions News 12 Long Island, had the longest known vocation in sports broadcasting.
In his prime, Mr. Wolff called two of the most famous games in American sports history: Don Larsens perfect game for the New York Yankees in the 1956 World Series and the 1958 National Football League championship game between the New York Giants and the Baltimore Colts, often called the greatest game ever played.
In addition to broadcasting Senators games for 14 years, Mr. Wolff did play-by-play for the Washington Redskins and the University of Maryland, national baseball and football broadcasts for the old Mutual radio network, and even several inaugural parades in Washington. In all, he broadcast eight different sports an impressive range and averaged more than 250 live events each year until he was well into his 80s.
He also wrote three books, appeared as a local radio and TV sportscaster in Washington and New York, and found time to be the announcer for the annual Westminster Kennel Club Dog Show at New Yorks Madison Square Garden for more than 30 years.
Mr. Wolff once estimated that he had covered more than 11,000 sporting events and that he had spent more than eight days of his life standing for the playing of the national anthem.
I felt the one thing that gave me longevity was coming up with angles, creative points, story lines, he told the Philadelphia Inquirer in 2005. I approached every sport with the soul of a sportswriter.
He was the only broadcaster to have called the championship games in all four major professional sports: baseball, football, basketball and hockey. He was also one of only two broadcasters, along with Curt Gowdy, to be enshrined in both the national baseball and basketball Halls of Fame.
His preparation and specificity to detail were unparalleled, Curt Smith, the author of Voices of the Game and other books about sportscasters, told The Washington Post in 1995. He speaks in sentences and full paragraphs. His voice is erudite but not unapproachable. He has a sense of humor with the old Senators, he had to and he was always honest.
Mr. Wolffs broadcasting style was unadorned and uninflected, and he often said he belonged to the less-is-more school. Unlike many younger sportscasters, he never developed a signature call or a series of Wolff-isms.
He was known for playing it straight, speaking in a midrange baritone with a prodigious vocabulary at his command.
Great calls used to be based upon the use of words as an art form, but now TV has changed that considerably, he told USA Today in 2011. ...Words carry nuance. I believe a part of my strength is matching the right nuances with the right words and not just using the same ones over and over again.
He also prided himself on meticulous some colleagues said obsessive preparation. For more than 40 years, Mr. Wolffs wife, Jane, would drive him to assignments so he could grab extra time to bone up on his pregame notes.
But when the action and tension grew more intense, so did Mr. Wolffs delivery. In his broadcast of the 1956 World Series for Mutual, he set the scene in the ninth inning as the New York Yankees Larsen faced Dale Mitchell of the Brooklyn Dodgers:
Two strikes and a ball Mitchell waiting, stands deep, feet close together. Larsen is ready, gets the sign. ... Here comes the pitch. Strike three! A no-hitter! A perfect game for Don Larsen! Yogi Berra runs out there. He leaps on Larsen and hes swarmed by his teammates. Listen to this crowd roar!
One of the greatest moments in baseball history became one of Mr. Wolffs signature calls as a broadcaster.
It just burst out of me, he told USA Today. You channel the emotion, excitement and tension.
In Washington, Mr. Wolff was the TV face and voice of the hapless Senators from 1947 to 1960. Only once in those years did the teams record exceed .500, which forced Mr. Wolff to develop a habit of never telling his listeners who was ahead.
Id look for human interest stories all the time to keep people listening to the game, he told the New York Times in 2013. Id just say, Well, folks, its 17-3, and they knew which team was losing.
He was at the microphone for one of the Senators lowest moments the famous 565-foot home run that the Yankees Mickey Mantle hit off hurler Chuck Stobbs in 1953. The home run is believed to be the longest ever hit in a major league baseball game.
When the Senators left Washington after the 1960 season, Mr. Wolff accompanied the team to its new home in Minnesota. After one season as the play-by-play voice of the Twins, he moved to New York, where he broadcast events at Madison Square Garden until he was nearly 80, including play-by-play coverage of the NHLs New York Rangers and, for 27 years, the NBAs New York Knicks.
He also did weekly baseball broadcasts for NBC-TV, teaming with former catcher Joe Garagiola.
With the Senators, Mr. Wolff often had to deliver commercials on live television. Once, he couldnt pry the lid off a can of Prince Albert pipe tobacco, straining and yakking until the lid finally flew open, spilling tobacco everywhere.
Prince Albert abdicated as a sponsor soon after that, Mr. Wolff recalled.
National Bohemian beer required Mr. Wolff to drink its product during breaks between innings.
By the seventh inning, I was kind of weaving my way through the broadcast, he recalled to the New York Daily News in 2003. He eventually prevailed on his bosses to hire a designated drinker.
Robert Alfred Wolff, whose father owned an engineering firm, was born Nov. 29, 1920, in New York City and grew up in the Long Island community of Woodmere. A self-described sports addict from a young age, he captained his high school basketball team and was one of the citys top baseball prospects.
He went to Duke University in Durham, N.C., to play baseball, but during his freshman year he broke his ankle during a baserunning drill.
He was invited to be a guest on a radio station broadcasting Dukes games and soon was serving as a color analyst and as the host of a daytime sports variety show. Although he was eager to return to the playing field, his college coach gave him a bit of advice: If you want to get to the big leagues, I suggest you keep talking.
He graduated in 1942, then served with the Navy in the Pacific during World War II. After his discharge, he resumed his radio career in Durham. In 1946, he got an offer to join WINX-AM in Washington and, a year later, became the first TV announcer for the Senators.
Mr. Wolff, who was about the same age as most of the Senators players, traveled with the team and grew close to the players, often tossing batting practice before games.
He formed the Singing Senators, a group of players who sang barbershop tunes while Mr. Wolff strummed the ukulele.
He crooned Take Me Out to the Ballgame, accompanying himself on the ukulele, when he was inducted into the broadcasters wing of the Baseball Hall of Fame in 1995. He was elected to the Naismith Memorial Basketball Hall of Fame in 2008.
In 2013, Mr. Wolff donated more than 1,000 hours of tapes to the Library of Congress, including his on-air interviews with such historic sports figures as Ty Cobb, Babe Ruth, Jim Thorpe, Ted Williams and Jackie Robinson.
In 1945, he married Jane Hoy, a former naval nurse whom he met during the war. Besides his wife, survivors include three children: Rick Wolff of Armonk, N.Y., Robert Wolff of Boston, and Margy Clark of Avon, Conn.; nine grandchildren; and 11 great-grandchildren.
During his years in Washington, Mr. Wolff often ventured outside the booth to roam the stands at the old Griffith Stadium, interviewing die-hard Senators fans. Between the games of a doubleheader in 1957, he approached a spectator sitting near the dugout, telling him: Lets play a game. Dont say your name until were finished talking.
They spoke about the game and various players before Mr. Wolff asked the fan about himself.
What sort of work do you do, sir?
I work for the government, the fan responded.
Oh, for the government?
Well, Richard M. Nixon finally said, Im the vice president.
Bob Levey is a retired Washington Post columnist.
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The ‘unicorn’ test was always a stupid way to judge a start-up — it’s even stupider with health tech – CNBC
Posted: at 3:45 am
The conventional wisdom in Silicon Valley is that digital health is over-hyped and under-performing due to the lack of "unicorns," meaning start-ups valued at more than $1 billion.
That argument was summed up last month by a contributor to Forbes, who shared a plethora of reasons that the digital health category had "failed" to build multibillion-dollar businesses.
This whole argument is problematic for two big reasons.
First, it's plain wrong. There are a handful of health-technology unicorns.
In response to the article, health investor Halle Tecco spent an evening compiling a list of unicorns in the space that include Zocdoc, 23andMe, Human Longevity and Collective Health. Just one of these companies, 23andMe, is currently valued at $1.1 billion
The second reason is more nuanced and relates to the obsession with unicorns more generally. Simply put, valuation is not how digital health companies should be judged.
These companies, which sit in at the convergence between tech and health, face different challenges than their counterparts in enterprise and consumer tech. Many of them will face regulatory hurdles, which slows down growth; they're often heavy on services, as changing health behaviors is challenging; and they are typically selling to insurance companies or employers rather than directly to consumers.
To get those lucrative contracts with payers, these companies need evidence to prove that their product or service actually works. A coaching app for people with diabetes might sit in a sexy space and garner a huge valuation -- but if people only use it for a few weeks then drop it forever, the business will fail.
"We need to be looking at validation, rather than valuation," explains Tom Cassels, executive director at The Advisory Board Company, a health research firm based in Washington, D.C.
Cassels assesses digital health start-ups based on the following factors:
Cassels believes companies need to demonstrate that people with costly chronic conditions are actively using it in the long-run -- and that can take a while.
Meanwhile, some of the most valuable digital health start-ups are less than five years old.
"If companies can get to that, it means value is being created and the amount of money that can be saved by their customers is measurable," he said. "If you can get that revenue model right, the start-up is likely to have legs."
Many of the companies that Cassels expects to succeed in digital health are not on Tecco's unicorn list. Conversely, many that are on that list don't meet his criterion, particularly those that cater to the so-called "worried well."
Among his favorite companies are Empiric Health, a start-up spun out of health system giant Intermountain Health geared to evidence-based medicine, and PeraHealth, which sells tools to hospitals to monitor at-risk patients.
"There are only a handful of companies that would pass the validation, not the valuation test," he said.
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The 'unicorn' test was always a stupid way to judge a start-up -- it's even stupider with health tech - CNBC
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Bill Maher Says His Use of N-Word on Live TV ‘Not Racist Mistake’ – Newsweek
Posted: at 3:43 am
Comedian Bill Maher was quick to apologize in June after he faced widespread criticism for using the N word in an interview with Senator Ben Sasse on his HBO talk show.In a statement, Maher said the word was offensive, and I regret saying it and am very sorry.
In the June 3 episode of Real Time that led to calls for Maher to be fired, Republican Senator Ben Sassecommented that hed be welcome in Nebraska as we'd love to have you work in the fields with us.
Work in the fields? Maher replied. Senator, Im a house nigger. After some audience members groaned, Maher clarified: Its a joke.
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Despite apologizing, in aNew York Times Table for Three interview with Annie Liebowitz and Phillip Galanes published weeksafter the controversy, Maher took issue with the furor. I think most people understood that it was a comedians mistake, not a racist mistake, Maher said, when asked by Galanes if he was scared of losing his job.
The conversation then moved on to Ice Cubes June 9 appearance on Mahers Real Time, where the rapper confronted the comedian over his use of the N-word.
On the show, Ice Cube said that Mahers use of the word was part of him often crossingthe line on issues of race and comedy."I think we need to get to the root of the psyche, Ice Cube said. It's a lot of guys out there who cross the line because they're a little too familiar. Or, guys that, you know, might have a black girlfriend or two that made them Kool-Aid every now and then, and then they think they can cross the line. And they cant." He was evidently referring to Maher's past troubled relationships with black women.
Read more:People are calling for Bill Maher to be fired after he used the N-word on live TV
Over lunch with Annie Liebowitz and Phillip Galanes,Maher claimedthe rapper had tried to get him to admit things that arent true.
I've never made black jokes. Ive made jokes about racists. But my fan base knows that, so it never went anywhere.
Listen, I hope we had a teachable moment about race: trying to make something good from something bad. But maybe also about how to handle something like this: apologize sincerely if youre wrong and I was and own it, Maher said.
The controversy over Mahers use of the N-word didn't stop himrecently being nominated for his 40th Emmy award.It was not the first time Maher has been criticized for jokes and comments touching on race and religion.His ABC show Politically Incorrect With Bill Maher wascanceled in 2002 after he suggested that the 9/11 hijackers were not cowards. Critics say he has a history of making Islamophobic comments.
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Bill Maher Says His Use of N-Word on Live TV 'Not Racist Mistake' - Newsweek
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