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Category Archives: Transhuman News
Apparently, Most of Your DNA is Garbage – Men’s Health
Posted: July 20, 2017 at 2:46 am
Men's Health | Apparently, Most of Your DNA is Garbage Men's Health Anyone have somewhat fond memories of that day in high school biology when you got to re-create DNA using marshmallows and toothpicks? Whether or not you can remember the names of the different parts (or even that DNA actually stands for ... |
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Apparently, Most of Your DNA is Garbage - Men's Health
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DNA Testing Suggests Dogs Needed No Convincing to Befriend Humans – Gizmodo
Posted: at 2:46 am
Dogs have loved us for thousands of years, despite humanitys many flaws and foibles. New research suggests dogs were domesticated from wolves just oncethats all it might have taken for puppers and people to form an everlasting alliance.
The study, which was published online yesterday in Nature Communications, analyzed the genomes of two ancient German doggosone 7,000 years-old and the other 4,700 years-old. The researchers compared their dog DNA data to the genome of a 4,800 year old dog from Ireland that other scientists had studied in 2016, and to modern dog genomes. In that study, published last year in Science, researchers put forth a dual origin idea that dogs were domesticated from wolves on two separate occasions, in Europe and Asia. But in this recent study, researchers wrote their ancient doggos predominantly share[d] ancestry with modern European dogs. In other words, there might have actually been a single origin, although the precise location where dogs were first domesticated is still somewhat of a mystery.
We came to the conclusion that our data consisting of prehistoric three Neolithic genomes and DNA from thousands of modern dogs from across the world supported only a single domestication event from a group of wolves somewhere in Eurasia sometime between 20,000 to 40,000 years ago, co-author Krishna Veeramah, an assistant professor of ecology and evolution at Stony Brook University, told Gizmodo. In addition, most of the dogs people keep as pets today are likely genetically the descendants of the dogs that lived amongst the first European farmers 7,000 years ago, and perhaps even as far back as 14,000 years ago when people were still practicing a hunter-gatherer lifestyle.
Dogs were the first animal to be domesticated by humans. Anyone who owns a cat can tell you that felines were definitely domesticated long afterward. While this new study wont end the argument over how many times dogs were domesticated, it does offer a compelling, simple solution.
One the face of it you might think, why is it important that there was one, two, three or even four domestication events? Veeramah explained. But if youre trying to find out how and why it occurs, whether it was one or more is important. Humans and wolves have likely lived in the same region for maybe 40,000 years. So if the process of domestication only occurred once, this tells us it was likely very hard to do.
Humanity is constantly evolving, and has reinvented and embarrassed itself so many ways over the course of thousands of years. But in this ever-shifting nebula of chaos we call life, at least one thing remains true: the dogs are good.
[Nature]
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DNA Testing Suggests Dogs Needed No Convincing to Befriend Humans - Gizmodo
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To Jasmine As Long As He Can: Terrified OfRasheeda’s Reaction – Hollywood Life
Posted: at 2:46 am
L&HH star Kirk Frost is hoping he can save his marriage with Rasheeda by waiting as long as possible to reveal his DNA results for Jasmine Washingtons baby. Get the EXCLUSIVE details here!
Is he the father?! Kirk Frost, 48, is fighting for his marriage with wife Rasheeda, 35,and is not ready to hand over his DNA results that will claim if he is or isnt the father to Jasmine Washingtons baby. Kirk is burying his head in the sand and hiding from the inevitable, a source EXCLUSIVELY told HollywoodLife.com. Right now hes so wrapped up in trying to get Rasheeda back, the last thing he wants to do is confirm to her and the world that he had a baby by another woman. Hes putting off handing over the results as long as he can. Its not clear how long Kirk is planning on avoiding the issue but hes going to have to face it someday. It doesnt make any sense because theres no way to run from this forever, but Kirk doesnt seem to think thats the case, the source continued. Hes got this crazy idea that he can still find a way to dodge this bullet and save his marriage. Hes living in total denial but thats where his head is at. See Kirks shocking text messages during his alleged affair with Jasmine here!
Kirk married Rasheeda back in 1999 and the couple have two children together. News of his possible infidelity came as a shock to many when Jasmine filed court papers in Jan. 2017 demanding he pay child support. The paternity test was soon requested and everyones been on edge just waiting to see if Kirk really is the father of Kannon Mekhi Washington who was born in 2016. Rasheeda was understandably heartbroken when she found out about her husbands relationship with Jasmine and the possibility that the baby might be his just increases the pain. However, she has admitted on L&HH that if the baby is Kirks she would allow it to get to know her family. Now, thats selfless!
Despite Rasheedas patience with Kirk up to this point, the way things ended on the most recent finale of the show proves that it may not continue to be all sunshine and roses for the couple. The highly anticipated DNA results never happened and it leads many to speculate that Kirk and his past will continue to haunt him until it ultimately ends his bond with Rasheeda. It looks like only time will tell with this situation but we hope the answers come soon!
HollywoodLifers, what do you think about Kirk holding back on the DNA results? Tell us here!
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To Jasmine As Long As He Can: Terrified OfRasheeda's Reaction - Hollywood Life
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Saucy dealings; Madonna’s DNA not for sale; Dr. Phil’s big money – SFGate
Posted: at 2:46 am
Chronicle Staff and News Services
Photo: Frank Wiese, Associated Press
Rapper Tupac Shakur was killed in 1996.
Rapper Tupac Shakur was killed in 1996.
Dr. Phil is making lots and lots of money.
Dr. Phil is making lots and lots of money.
Saucy dealings; Madonnas DNA not for sale; Dr. Phils big money
Number of the day
$4.2 billion
Thats how much U.S. spice maker McCormick & Co. paid for the food business of Reckitt Benckiser, the maker of such items as Frenchs mustard and Franks RedHot sauce. The combined group is expected to have annual sales of around $5 billion. In an unrelated condiment development, Heinz recognized National Hot Dog Day and the reluctance of Chicagoans to put ketchup on a hot dog by offering Chicago Dog Sauce in a limited-edition bottle. It looks an awful lot like, uh, ketchup.
No, you cant buy Madonnas DNA
A New York judge has stopped an impending auction of Madonnas personal items, including a love letter from ex-boyfriend Tupac Shakur, a pair of worn panties and a hairbrush containing her hair. The Material Girl sought an emergency court order saying she was shocked at the planned online auction by Gotta Have It Collectibles, and said a former friend is behind the sale. Its outrageous and grossly offensive her DNA could be auctioned, she said.
But Dr. Phil could
have won the bidding
Speaking of wealthy entertainers, Forbes has come out with its annual list of the worlds top-earning TV personalities. Phil McGraw leads the list with $79 million, followed, in order, by Ellen DeGeneres, Jerry Seinfeld, Gordon Ramsay and Ryan Seacrest. The earnings include income from additional activities such as producing, non-TV performances, endorsements and merchandising.
Compiled from staff and news services. See more items and links at http://www.sfgate.com. Twitter: @techchronicle
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‘AstroKate,’ the First to Perform DNA Sequencing in Space, Speaks at ISS Conference – R & D Magazine
Posted: at 2:46 am
NASA astronaut Kate Rubins recapped her 150 days in space during the second day of the International Space Station (ISS) R&D 2017 Conference.
Rubins, the first person to sequence DNA on the ISS by culturing beating heart cells, took part in the session on July 18 at the annual conference held in Washington D.C.
DNA sequencing identifies an organisms blueprintthe process used to determine the precise order of the four chemical building blocks in a single DNA strand. Scientists use it to advance research, including identifying the genes responsible for certain genetic diseases through the blueprints.
Rubins used a hand-held, USB-powered DNA sequencerthe MinIONto determine the DNA sequencing for a mouse, bacteria and a virus. The goal of the experiment was to show that DNA sequencing is possible in space, which could lead to the potential to enable the identification of microorganisms, monitor changes in microbes and humans in response to spaceflight, as well as aid in the detection of DNA-based life elsewhere in the universe.
Rubins investigated where human skin cells were induced to become stem cells, enabling them to differentiate into any type of cell. The research team forced stem cells to grow into human heart cells and cultured aboard the space station for one month.
During her time in space, Rubins gained a cult following and has been dubbed #AstroKate by internet commenters. Rubins earned a doctorate in cancer biology from Stanford University and was selected in 2009 for the 20th NASA astronaut class after she helped develop the first smallpox infection model for the U.S. Army Medical Research Institute of Infectious Diseases and the U.S. Centers for Disease Control and Prevention.
Joining Rubins for the Revolutionizing Science from Ground to Orbit session was Dr. Arun Sharma, from Harvard Medical School and Sarah Wallace, Ph.D., from NASA to discuss in a discussion on their ground-based experience with respect to space-based research design decisions, preparations and expectations.
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'AstroKate,' the First to Perform DNA Sequencing in Space, Speaks at ISS Conference - R & D Magazine
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Nasty, Brutish and Short: Are Humans DNA-Wired to Kill? – Scientific American
Posted: at 2:46 am
After carefully dissecting out the muscles of a disembodied arm, biologist David Carrier and his team tied fishing lines from each isolated tendon to a guitar tuner knob, allowing the researchers to move the fingers around like ghastly marionettes. Using this setup, they could measure the varying strain on the bones when the hand was arranged in different positions and slammed into a padded dumbbell weight. Each limb took a week to prepare, but Carrier, who is head of the Evolutionary Biomechanics Lab at the University of Utah, wanted to get the study right. He had a point to provethat humankind has evolved for violence.
The 2015 paper that resulted from Carriers research showed that a buttressed fist, one with the thumb closed against the index and middle fingers, provides asafer way to hit someonewith force. Given that none of our primate cousins have the ability to make such a fist, Carrier and his co-authors propose that our hand proportions may have evolved specifically to turn our hands into more effective weapons. The research is just the latest in a string of studies Carrier has conducted to define a suite of distinguishing characteristics that are consistent with the idea that were specialized, at some level, for aggressive behavior. Through experiments with live fighters as well as with cadaver arms, he and his colleagues have reimagined our faces,hands, andupright postureas attributes that evolved to help us fight one another.
Carriers conclusions have proven contentious: Critics argue that just because a buttressed fist protects the hand during a punch doesnt mean the hand evolved that way for this specific reason any more than the human nose evolved to hold up glasses. But peoples discomfort with Carriers hypothesis goes beyond this critique. The work is sensitive because it tackles a controversial question: Are humans biologically designed for violence, or are violence and war cultural phenomena?
While many biological anthropologists have, like Carrier, arrived at the former conclusion, albeit for different reasons, cultural anthropologists tend to argue for the latter. A major take-away from the anthropological literature is that humans have thepotential, which is different from thetendency, to be violent, says Alisse Waterston, president of the American Anthropological Association (AAA), and a cultural anthropologist at the City University of New York who studies violence. But ever since the 17th-century thinker Thomas Hobbes famously described the lives of humans in their natural condition prior to the development of civil society as nasty, brutish, and short, there have been scholars such as Carrier who suggest that violence has molded our speciesthat its been etched into our bodies and minds.
Theories can encompass both biological and cultural viewpoints, of course, but in this debate, the conflict between the different perspectives has at times verged on the intensity of one of Carriers fistfights. The debate is nuanced, and it cuts right to the heart of humanitys perception of itselfas well as our collective desire for world peace.
The idea of a biological imperative for violence achieved prominence in the 1970s with the emergence of a new discipline: sociobiology. While the concept of violence being intrinsic to human nature had been around since Hobbes time, sociobiologists (and later evolutionary psychologists) specifically argued that behaviors, not just physical characteristics, can be shaped by natural selection. This meant that common behaviors like violence could be genetically determined.
The debate cuts right to the heart of humanitys perception of itselfas well as our collective desire for world peace.
At the heart of the popularization of this idea stands Napoleon Chagnon, sometimes called Americas most controversial anthropologist. Chagnon caused an uproar in 1968 when he published observations of the Yanomami people of Venezuela and Brazil, describing them as a fierce people who were in a state of chronic warfare. He asserted that Yanomami men who kill have more wives and therefore father more children: evidence of selection for violence in action. This represented a wild divergence from the anthropological consensus. Anthropologists criticized virtually every aspect of Chagnons work, from his methods to his conclusions. But for sociobiologists, this was a prime example that supported their theories.
Around the same time, David Adams, a neurophysiologist and psychologist at Wesleyan University, was inspired to investigate thebrain mechanisms underlying aggression. He spent decades studying how different parts of the brain reacted when engaged in aggression. By using electrical stimulation of specific brain regions and through creating various lesions in mammalian brains, he sought to understand the origins of different antagonistic behaviors. But Adams found the public response to his work over the top: The mass media would take [our work] and interpret it like wed found the basis for war, he says. Tired of the way his results were being interpreted by both the media and the public, Adams eventually switched gears entirely.
In 1986, Adams gathered a group of 20 scientists, including biologists, psychologists, and neuroscientists, to issue what became known as theSeville Statement on Violence. It declared, among other things, that it is scientifically incorrect to say that war or any other violent behavior is genetically programmed into our human nature. The statement, later adopted by UNESCO, an agency of the United Nations that promotes international collaboration and peace, was an effort to shake off the biological pessimism that had taken hold and make it clear that peace is a realistic goal. The press, however, was not so enthralled by Adams new tack. This is not interesting for us, one major news network responded when he asked if they would cover the Seville statement, he recalls. But when you do find the gene for war, call us back.
The Seville statement by no means ended the academic debate. Since its release, various prominent researchers have continued to advance biological arguments for our innate tendency towards violence, in contradiction of both the statement and the views of many cultural anthropologists. In 1996, Richard Wrangham, a biological anthropologist and primatologist at Harvard University, published his popular bookDemonic Males, co-authored with science writer Dale Peterson, that argued we are the dazed survivors of a continuous 5-million-year habit of lethal aggression. Central to this proposition is the idea that men, or demonic males, have been selected for violence because it confers advantages on them. Wrangham argued that murderous attacks by groups of male chimpanzees on smaller groups increased their dominance over neighboring communities, improving their access to food and female mates. Perhaps, like chimpanzees, ancestral men fought to establish dominance by killing rivals from other groups, thus securing greater reproductive success. InWranghams view, such behavior selected for males who are endowed with a certain desire for violence when the conditions are right: the experience of a victory thrill, an enjoyment of the chase, a tendency for easy dehumanization (or dechimpization).
I think the growing evidence about innate propensities for violence have shown [the Seville statement] rather clearly to be simplistic and exaggerated at best, says Wrangham.
Akey proponent of this biological view is psychologist Steven Pinker, another Harvard researcher whose writing, particularly his 2011 bookThe Better Angels of Our Nature, has significantly shaped the conversation about human violence in recent years. In his 2002 bookThe Blank Slate, Pinker wrote, When we look at human bodies and brains, we find more direct signs of design for aggression, explaining that men in particular bear the marks of an evolutionary history of violent male-male competition. Onewidely quoted estimateby Pinker places the death rate resulting from lethal violence in nonstate societies, based on archaeological evidence, at a shocking 15 percent of the population.
Physical indicators, such as those studied by Carrier, can be viewed as evidence that selection for violence-enabling features has taken place. Carrier sees signs of design for aggression everywhere on the human body: In a recent paper, co-authored with biologistChristopher CunninghamfromSwansea University,he suggests thatour foot postureis an adaptation for fighting performance. He has even proposed, as part of his fist-fighting hypothesis, that the morerobust facial featuresof men (as opposed to women) evolved to withstand a punch.
I really dont think its debatable that aggression has shaped human evolution, agrees Aaron Sell, an evolutionary psychologist at Griffith University in Australia, who has explored the combat design of human males. Sell hascompiled a listof 26 gender differences, ranging from greater upper body strength to larger sweat capacity, thatsuggest adaptation for fightingin human males. It is a very incomplete list though, he adds.
Many anthropologists remain unconvinced by those who suggest that there is an evolutionary advantage in violence and a deep biological explanation for conflict. Theyre just barking up the wrong tree, says Douglas Fry, an anthropologist who specializes in the study of war and peace at the University of Alabama, Birmingham.We are well designed to prevent ourselves getting into lethal conflicts and to avoid the actual physical confrontation, he argues, describing the idea that we are innately predisposed to violence as a cultural belief that is just plain wrong.
David Carrier is an excellent biomechanist who conducts careful and clever experiments, says Caley Orr, a paleoanthropologist at the University of Colorado School of Medicine. Hes probably right when he talks about the biomechanicalconsequencesof some of the anatomy, but that is different from resolving what the evolutionary selective pressures were that shaped it in the first place.
Polly Wiessner, an Arizona State University anthropologist whostudies warfare and peacemakingin the Enga of highland Papua New Guinea as well as social networks for risk reduction in the !Kung of the Kalahari Desert, points out another potential problem with Carriers logic: I dont know of anyone [in traditional societies] who fistfights; people wrestle, she explains, adding that if they really want to do someone in, people in such societies simply use weapons. If punching is uncommon in these societies, its reasonable to assume this type of combat wasnt a key factor in our evolution.
More broadly, if violence and warfare are not ubiquitous throughout traditional societies, this would suggest that these human behaviors are not innate, but rather arise from culture. Fry hasextensively examinedboth archaeological and contemporary evidence, and has documented over70 societies that dont make warat all, from the Martu of Australia, who have no words for feud or warfare, to the Semai of Malaysia, who simply flee into the forest when faced with conflict. He also argues that there is very little archaeological evidence for group conflicts in our distant past, suggesting war only became common as larger, sedentary civilizations emerged around 12,000 years agothe opposite of Pinkers conclusions.
Chimpanzees might just be ultra-violent outliers.
As for our primate cousins, according to primatologist Frans de Waal of Emory University, theirbehavior has been cherry-pickedto suit a more violent narrative for humanity. While chimp behavior may well shed light on human male tendencies for violence, de Waal points out that the other two of our three closest relatives, bonobos and gorillas, are less violent than us. In even the most peaceful human societies, of course, violence in one form or another is not totally unknown, and the same is true of these peaceful apes. Nevertheless, it is plausible that instead of descending from chimp-like ancestors, we come from a lineage of relatively peaceful, female-dominated apes, like bonobos. Chimpanzees might just be ultra-violent outliers.
That our evolutionary success is based largely on our ability to be violentthats just wrong, says biological anthropologist Agustn Fuentes,who is chair of anthropology at the University of Notre Dame in Indiana. The sum total of data we have from the genetics to the behavioral to the fossil to the archaeological suggests that is not the case.
Scholars and researchers on both sides of the debate want their work applied to achieve more peaceful societies, and most agree that humans are capable of both great acts of violence and great acts of kindness. Yet from Chagnon onward, there has been a palpable degree of tension between those who hold opposing viewpoints. In anopen letter to de Waalin 2005, University of Groningen anthropologist Johan van der Dennen complained of feeling shouted down by the peace and harmony mafia.
At issue is the fact that for some a biological explanation suggests that violence is unavoidable. If we accept that violence is inherent, says Fuentes, we start to accept unpleasant behavior as inevitable and indeed natural in ourselves and those around us. The old adage that violence begets violence is true, says AAA President Waterston. A society that adopts and is adapted to violence tends to reproduce it, locating and leveraging the resources to do so.
John Horgan, science journalist and author ofThe End of War, has been conductinginformal surveys with studentsfor years, and he reports that over 90 percent of respondents think we will never stop fighting wars. And when Adamsandothers conducted their own studies on student attitudes, they observed a worrying effect: There was anegative correlationbetween the belief that violence was innate and peace activism. Even among those students whowereactively campaigning for peace, 29 percent reported that they had previously been put off by a pessimistic view that humans are intrinsically violent. Adams predicts that the level of apathy would be higher among those who abstained from activism altogether: If you think that war is inevitable, why oppose it? he says.
Such fatalistic attitudes are particularly worrying when held by those in power: They can be used to justify military budgets, and not seek alternative solutions, argues de Waal. Even Nobel Peace Prizewinning former U.S. President Barack Obama seems to believe that violence is bred into humanity: War, in one form or another, appeared with the first man, he said in his Nobel Prize acceptance speech. With Obamas entire tenure spent leading a nation at waralbeit war that he inherited from his predecessorHorganhas wonderedif the former presidents personal belief in the deep-roots theory of war might have prevented him from more actively seeking peace.
But Obama, like Hobbes and Pinker, has also argued that society is equipped to fight the supposed biological imperative for violence: We have increasingly created codes of law and philosophies to limit violent acts, thanks to our capacity for empathy and reason. InTheBetter Angels of Our Nature, Pinker elegantly charts what he sees as a decline in violence, from the frightening 15 percent of violent deaths in nonstate societies down to 3 percent of deaths attributed to war, genocide, and other human-made disasters in the 20th centurya period that includes two world wars.
Waterston, exasperated by the tired assumption that violence is rooted in human nature, explains that for her the question should simply be about what circumstances are required for there to be less violence. Yet those seeking biological explanations see themselves as getting to the core of the issue in order to answer this question. Carrier offers an analogy to alcoholism: If you have a predisposition to drinking excessively, you must recognize those tendencies, and the reasons behind them, in order to fight them. We want to prevent violence in the future, says Carrier, but were not going to get there if we keep making the same mistakes over and over again because we are in denial about who we are. Chimpanzee research, for example, demonstrates how balanced power between groups tends to limit violence. The same is clearly true of humans, Wrangham notes. Probing that simple formula, with all its complexities, seems to me a very worthwhile endeavor.
There may be disagreement about how to get there, but all involved are trying to attain the same end goal. An evolutionary analysis does not purport to condemn humans to violence, explains Wrangham. What it does achieve is a more precise understanding of the conditions that favor the highly unusual circumstance of peace.
This article is reproduced with permission fromwww.sapiens.org.The article wasfirst publishedon July 12, 2017.
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Nasty, Brutish and Short: Are Humans DNA-Wired to Kill? - Scientific American
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Only 10-25% of Human Genome is Functional, New Estimate Says – Sci-News.com
Posted: at 2:46 am
In a paper published in the journal Genome Biology and Evolution, University of Houston Professor Dan Graur says that the functional portion of the human genome probably falls between 10% and 15%, with an upper limit of 25%. These figures are very different from one (about 80%) given in 2012 by the Encyclopedia of DNA Elements (ENCODE) project, but more optimistic than the 2014 estimate (8.2%) by Rands et al.
According to Professor Graur, the functional fraction within the human genome cannot exceed 25%, and is probably considerably lower.
Professor Graur took a deceptively simple approach to determining how much of the genome is functional, using the deleterious mutation rate that is, the rate at which harmful mutations occur and the replacement fertility rate.
Both genome size and the rate of deleterious mutations in functional parts of the genome have previously been determined, and historical data documents human population levels.
With that information, the researcher developed a model to calculate the decrease in reproductive success induced by harmful mutations, known as the mutational load, in relation to the portion of the genome that is functional.
The functional portion of the genome is described as that which has a selected-effect function, that is, a function that arose through and is maintained by natural selection.
Protein-coding genes, RNA-specifying genes and DNA receptors are examples of selected-effect functions.
In Professor Graurs model, only functional portions of the genome can be damaged by deleterious mutations; mutations in nonfunctional portions are neutral since functionless parts can be neither damaged nor improved.
Because of deleterious mutations, each couple in each generation must produce slightly more children than two to maintain a constant population size.
Over the past 200,000 years, replacement-level fertility rates have ranged from 2.1 to 3 children per couple; global population remained remarkably stable until the beginning of the 19th century, when decreased mortality in newborns resulted in fertility rates exceeding replacement levels, Professor Graur said.
If 80% of the genome were functional, unrealistically high birth rates would be required to sustain the population even if the deleterious mutation rate were at the low end of estimates.
For 80% of the human genome to be functional, each couple in the world would have to beget on average 15 children and all but two would have to die or fail to reproduce.
If we use the upper bound for the deleterious mutation rate (2108 mutations per nucleotide per generation), then the number of children that each couple would have to have to maintain a constant population size would exceed the number of stars in the visible Universe by ten orders of magnitude.
_____
Dan Graur. An upper limit on the functional fraction of the human genome. Genome Biol Evol, published online July 11, 2017; doi: 10.1093/gbe/evx121
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Bio-Rad Laboratories Aims to Create Genome Editing Tools Pipeline, Starting With ddPCR – GenomeWeb
Posted: at 2:46 am
NEW YORK (GenomeWeb) Genome editing continues to be one of the most compelling trends in biological research as investigators maintain a steady pace of studies and papers on new CRISPR-Cas systems, innovative research tools, and various uses for the technology.
But academia is certainly not alone in its enthusiasm for CRISPR industry is joining in as various companies are either setting out to develop new tools based on the genome editing technology or find CRISPR-based applications for tools that already exist.
A trial upgrade to GenomeWeb Premium gives you full site access, interest-based email alerts, access to archives, and more. Never miss another important industry story.
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Bio-Rad Laboratories Aims to Create Genome Editing Tools Pipeline, Starting With ddPCR - GenomeWeb
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The role of AI in the future of health care | VentureBeat | AI | by Peter … – VentureBeat
Posted: at 2:45 am
American physician and surgeon William J. Mayo, one of the founders of the famed Mayo Clinic, stated, The aim of medicine is to prevent disease and prolong life, the ideal of medicine is to eliminate the need of a physician. Emerging applications of artificial intelligence (AI), as well as medical research trends, suggests that we are moving toward fulfilling medicines aim and achieving its ideal.
Health care organizations appear to be preparing themselves for the next technological step. For instance, in 2014 health care providersspent4.2 percent of their revenues on IT, compared to a 3.3 percent cross-industry average. Penetration of electronic health care recordsgrewfrom 40 percent in 2012 to 67 percent in 2017. With its wealth of smart machines, health care is expected to be among the fastest growing industries in terms of data generated. Ciscoestimatesa 2015-2020 CAGR (compound annual growth rate) of machine-to-machine connections in health care to be 30 percent, more than the expected 29 percent growth rate for connected cars.
The next big thing in health care is also anticipated by investors, who have increased their bets on the segment. Venture capital investment in cutting-edge, AI-driven medical technologies like computer vision, machine learning (ML), and robotics hasskyrocketedfrom $30 million in 2012 to $892 million in 2016.
Studying the academic and funding dimensions of the medical AI ecosystem, we see that the movement towards Mayos vision is taking place. Prediction and prevention, wellness and rehabilitation, amelioration of aging, and technological augmentation of doctors are all noticeable themes.
Prediction and prevention are well-known concepts for health care professionals. Now they appear to be revitalized and reinforced by machine learning. A dive into PubMed databases demonstrates that the pace of research activity for ML-powered prediction and prevention is currently higher than the research activity associated with these concepts without involving ML.
AI health care startups working with predictive and preventive medicine are a new phenomenon that seems to embrace growing research. Out of 218 health care AI startups selected from an industry database, 54 were involved in predictive medicine, with 44 founded in 2010 or later.
Some companies, likeJvionandHBI Solutions, provide health care organizations with patient-level predictions and risk scores. Others, likeOcuvera, bring prevention to hospitals operations by, for example, by identifying a patients proclivity to fall and helping to avoid the accident.
Activity in the wellness segment of the health care value chain also reflects growing interest in the preventive aspect of medicine. Wellness appears to be the fastest-growing segment among the core segments of the health care value chain.
Researchers attention to the wellness segment is matched by entrepreneurs interest. Out of 218 AI health care startups, 21 develop wellness applications.
Startup funding data suggests that younger startups tend to work with wellness applications. About 95 percent of AI-powered wellness startups were founded in 2010 or later, compared with 57 percent of those tackling surgery-related issues.
Wellness applications may use almost unlimited data from healthy populations, the collection of which is accelerated by new devices entering the market. The more data from healthy patients is available, the more insight one can get. Traditional health care uses data that is limited by the number of cases and more severe sampling requirements.
Prevention and prediction segments start from research into cells and genetics, aiming to eliminate the underlying causes of dangerous diseases. Machine learning drives these research topics as well.
Founding data for AI startups helps to identify the uptick in launching startups working with cell and genetic research. For example, notable companies such asHuman Longevity,BenevolentAI,Recursion Pharmaceuticals, and at least seven others were launched between 2010 and 2017.
Following Mayos vision, health care researchers and founders try to make life longer by battling aging and making rehabilitation smoother. Medical research on aging is growing rapidly, compared with research on the leading causes of death in the U.S. It is also one of the fastest accelerating research area in the past six years.
Not being a disease in the traditional sense, aging is an excellent target for tech disruption, with no critical state (i.e., the fast deterioration of a patient) and developing across the whole lifespan. Aging research may benefit from lots of data collected during a patients life.
Already amassed data and evolving data collection technologies, combined with machine learning, contribute to fighting aging. For instance, this technology can check if senescence acceleration is taking place and estimate biological age more precisely. Then relevant treatment options can be selected.BioageLabsandInsilico Medicineuse machine learning to discover anti-aging drugs.
Rehabilitation is experiencing a growing research interest as well. It also benefits from AI as it requires long-term commitment, repetitive actions, and a continuous feedback loop. Twelve startups are moving the field of rehabilitation forward by, for instance, working with brain dysfunction rehabilitation likeIntenduor helping joint replacement patients likePeerwell.
The examples given above suggest that tech is moving medicine toward preventing diseases from happening. This can be done by tweaking genes, detecting early signs of diseases, and altering human behavior for health benefits. Currently AI tech penetrates just a part of the list of dangerous diseases.
Perhaps at some point, all diseases will be preventable and there will be no need for a physician. But can tech eliminate physicians before it eliminates diseases by replacing human doctors with robots and algorithms? Our observation suggests that this goal is not a heavy area of interest. Instead, AI-powered health tech looks to assist physicians and make them more accessible for patients.
Studying 35 companies that employ computer vision in health care, one may conclude, that their primary approach is to augment professionals, rather than to replace them. For example,BayLabsdevelops technology to simplify the process of recording, editing and sharing of video, whileMindshare Medicalaims to empower clinicians and health care providers by utilizing medical imaging.Oxford Heartbeathelps clinicians accurately plan and rehearse stent placements inside blood vessels.
Telemedicine is also empowering health care professionals rather than replacing them. In a world where 400 million people do not haveaccessto basic health care services, telemedicine is a viable option to keep doctors busy, even after efficiency grows manifold and demand in well-off regions starts decreasing. Out of 218 companies, 39 are in one way or another providing telemedicine technologies. Some help patients to navigate medical knowledge and make a preliminary diagnosis (Babylon,YourMD), while others give doctors unprecedented monitoring tools (Sentrian,AiCure) and provide valuable health-related information and advice (ZoiHealth,Flo). Medical research in telemedicine is also growing rapidly, rocketing from 317 articles in 2010 to 845 in 2016.
Our inquiry suggests that the vision of medicine coined by Mayo is closer to life then we think, thanks to AI. Cognitive technologies fit nicely with the popular research themes explored above. Moreover, at the current stage, where diseases are not eliminated entirely, tech empowers rather than displaces health professionals. Therefore, we expect to see more exciting AI health tech to emerge and suggest entrepreneurs consider opportunities in this space.
Notes on data collection: Trends on research activity are derived from searching titles and abstracts at PubMed. Data on AI health tech companies is from a keyword search and manual selection at Pitchbook.Flint Capital is an investor in Flo, an AI-powered period and ovulation tracker referred to in this article.
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Search for Eczema Relief Leads to Business Opportunities – New York Times
Posted: at 2:45 am
Eczema entrepreneurs are often driven by personal experiences that they or their family members have had with the skin condition. Joe Paulo, for example, created Smiling Panda clothing after he had eczema as a teenager. But he and others, including Ms. Scott, have found that the path to a winning eczema product is not short or easy, in large part because there is no official testing process to get approval.
Everyones eczema is different, and not everything works the same way on every patient, said Julie Block, president and chief executive of the National Eczema Association, which tracks developments in the field but does not endorse products. The association does offer a certificate of acceptance for companies that can show they have clinical safety testing data for their products.
The only apparel company to earn the associations grade so far is Ms. Scotts AD RescueWear, whose wet-wrap therapy garments relieve itching by sealing in moisture. Medical studies have shown such therapy helps eczema sufferers.
Ms. Scott discovered the therapy while searching for a way to help Harrison, who will be 9 in September. As a baby, his eczema was so severe that he got a staph infection from scratching. Dr. Mark A. Ebadi, an allergist at the Colorado Allergy and Asthma Center in Denver who was treating Harrison, recommended wet-wrap therapy.
Ms. Scott dressed her son in wet cotton pajamas, and at Dr. Ebadis suggestion taped her husbands tube socks around her sons hands for protection. But the wrapping was cumbersome.
It was off-putting to wrap a child in damp clothing, she said. And cotton pajamas got baggy, and my son would get cold. We needed something for him that was close fitting so it would be next to his skin.
It took a lot of trial and error, but Ms. Scott, who is an interior designer, gradually developed a full body suit with flat seams almost like a long-sleeve onesie with covers for her sons nails. The suit has attached feet, like those found on infant and toddler pajamas, to prevent children from scratching their legs and ankles, where clusters of eczema are often found.
I knew nothing about clothing manufacturing, Ms. Scott said. Eventually, she found a family-owned company in Michigan that was willing to produce a run of her sample suit. It was made from the artificial fiber Tencel, which retains more water so the material holds its shape and stays closer to the skin.
She called the body suit the Wrap-E-Soothe suit, but customers later began calling it the rescue suit a nickname her company quickly adopted. It sells for $109 for children. The product line later was expanded to include tops and pants, which cost $74.50, and sleeves, which cost $34.95, to cover childrens arms and legs.
Ms. Scott began selling the garments in 2012, the same year that she teamed up with Anne McVey, an experienced marketer in Davenport, Iowa, whose daughter has eczema. To test reaction from doctors, they took samples to an annual meeting of allergy, asthma and immunology specialists, held in San Antonio in 2013. The garments received good reviews, but Ms. Scott said it was an uphill climb to attract customers online because the product was little known.
She did not share specific numbers, but Ms. Scott said sales increased 70 percent last year to around 10,000 items over 2015. Repeat customers, the eczema associations certificate of acceptance and a medical product billing insurance code have all helped raise the sites visibility and attract business, Ms. Scott said.
Were aiming for 100,000 pieces annually, she added, noting that the site is adding garments for adults.
Mr. Paulo, 23, has already made some inroads with adults seeking relief with his Smiling Panda brand, which he started after getting eczema on his arms. The eczema appeared after he moved from California to Philadelphia in 2012 to attend college.
His eczema, he said, got significantly worse when he had to wear professional clothing during college internships. When even bedsheets began irritating his skin, he started researching the properties of different fibers and how clothing was made. He chose a bamboo-cotton blend for his clothing because bamboo is soft and cotton fibers allow a closer fit, he said. He began cutting and stitching his own shirts, with flat seams and no tags.
When he wore his shirts to bed, he said: I went from having a really tough time falling asleep to having no trouble at all.
I thought there might be other working adults interested in this type of clothing, and that comfortable clothing would help them in the same way it helped me, he said. He found a small manufacturer willing to make a batch of sizes for women and men. He chose Smiling Panda as the company name and started a website in February 2016.
Mr. Paulo, an engineer for a construction company, sold only about 70 shirts last year at $40 to $50 apiece.
But we are on track to sell 100 shirts this year, he said, despite limited advertising, mostly on Facebook. He added that sales were expected to pick up in coming months.
Many of the men and women who buy his garments for workout wear, undergarments and sleepwear are repeat buyers and are so committed that, in March, he decided to add childrens sizes.
Mr. Paulo said he did not know if the company would ever be profitable. I like doing it because I feel like our products make a difference in our customers lives, he said. I know from personal experience how miserable clothing can be when you are itching from eczema.
A version of this article appears in print on July 20, 2017, on Page B5 of the New York edition with the headline: Personal Stories Drive Start-Ups In Eczema Products.
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Search for Eczema Relief Leads to Business Opportunities - New York Times
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