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New Test Allows For Easier and Earlier Detection of Alzheimer’s – Futurism
Posted: July 23, 2017 at 12:40 am
In Brief A new blood test can detect buildups of beta-amyloid in the brain, the plaques that signal the development of Alzheimers disease. This test could mean earlier detection of the disease and more effective lifestyle interventions for patients. Early Detection
A new blood test has been found to be able to detect buildups of beta-amyloid in the brain, the cause of the plaques that characterize the development of Alzheimers disease. Although the role that these clumps of beta-amyloid play in the brains of Alzheimers patients is unknown, monitoring their presence has been a reliable way to watch for the disease. Unfortunately, watching for the build-up of these plaques in the brain has only been possible through PET-scans, which are expensive and not widely available, or with spinal tap procedures, which are invasive and can only be administered by a, relatively, select few practitioners.
In this new study, researchers have developed a simple blood test to screen for Alzheimers risk that anyone from general practitioners to nurses in clinics could use. This simple to administer screening would be able to identify thousands of at-risk patients, allowing them to start treatment before brain damage and irreversible memory loss occurs. In fact, with this kind of basic screening tool, monitoring for Alzheimers disease could be as widespread and quick as checking your cholesterol and blood sugar.
Although there is not yet any silver bullet treatment for Alzheimers disease, there are promising treatments on the horizon some that reverse symptoms, and others that slow the progression of the disease. However, the most important way to fight Alzheimers right now is through prevention. As scientists study why some brains resist the disease more than others and how we might prevent the disease entirely, evidence shows that lifestyle interventions including healthy diet and exercise can reduce the risk of Alzheimers disease by as much as 30 percent. Earlier detection with a blood test would make lifestyle interventions more effective.
Beta-amyloid plaques begin to accumulate 15 to 20 years before a person exhibits the symptoms of Alzheimers disease. Positive test results wouldnt guarantee that a patient would develop the disease, but they would signal possible risk while suggesting a need for lifestyle changes.
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Central South African Bank Will Experiment With Bitcoin Regulation – Futurism
Posted: at 12:40 am
In Brief The central South African bank is partnering with a blockchain-based solutions provider to experiment with digital currency regulations. This may bring digital currencies like Bitcoin further into the mainstream and legitimize their use. South African Bitcoin Experiment
The South African Reserve Bank, which functions as the countrys central bank, is partnering with blockchain-based solutions provider Bankymoon to experiment with digital currency regulations. Bankymoon will serve as a sandbox business as the team works with Bitcoin and other cryptocurrencies with the ultimate goal of understanding and legitimizing the growing adoption of cryptocurrency.
As with any new technology that becomesmainstream, regulation becomes an issue. However, cryptocurrencies and the blockchain technology they are based upon are, by nature, decentralized. Therefore, there is, at some level, a fundamental tension between the governments need or desire to regulate and the structure of the technology (not to mention the intent of its users).
However, government regulation of digital currencies could legitimize the technology. Gamaroff believes that regulations will strengthen and give legitimacy to Bitcoin and other digital currencies for novice users, I think the regulation will move things along and make people on the street comfortable with Bitcoin. With these new regulations, these everyday people can now trust that Bitcoin is not just for hackers and criminals.
The initiative also enjoys the support of some of South Africas leaders and biggest businesses. Former First National Bank CEO Michael Jordaan, for example, believes that digital currency is on track to render central banks and the entire traditional banking model obsolete. Only time will tell whether the government can involve itself in a meaningful way with this kind of regulation or if the technology will simply continue to expand without that type of constraint.
Disclosure: Several members of the Futurism team, including the editors of this piece, are personal investors in a number of cryptocurrency markets. Their personal investment perspectives have no impact on editorial content.
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Google Street View’s latest destination: The International Space Station – Washington Post
Posted: July 22, 2017 at 7:50 am
Youve used Google Street View to check out a new apartment, map traffic before you hit the road and search for haunting slices of the everyday world.
Now, the comprehensive terrestrial mapping system has gone extraterrestrial, allowing users to peer inside the International Space Stationfrom their computer 248 miles below with 360-degree, panoramic views.
The Street View imagery was captured by Thomas Pesquet, an astronaut with the European Space Agency, who spent six months aboard the ISS before returning to earth in June.
Google Street View, which is featured in Google Maps and Google World, was launched in 2007 and quickly expanded locations around the globe, including places as remote as Mount Everest base campand as offbeat as Scotlands Loch Ness. The vast majority of Street Views photography is shot by a vehicle, whose movement is available to fans online.
[The search for the Loch Ness monster has moved online, thanks to Google]
Googles foray into space is the first time StreetView imagery was captured beyond planet Earth.
In a blog post about his experience, Pesquet wrote that it was difficult to find the words or take a picture that accurately describes the feeling of being in space.
Working with Google on my latest mission, I captured Street View imagery to show what the ISS looks like from the inside, and share what its like to look down on Earth from space, he added.
The virtual tour allows users to peek into areas where astronauts eat, exercise, work and even bathe.
Pesquets imagery reveal an environment that may look a bit cramped and chaotic if not altogether dizzying to humans anchored on earth, but some of the scenes from inside the ISS are downright mesmerizing.
The images were captured using DSLR cameras and then stitched together back on earth to create panoramic views.
Pesquet noted that the ISS is a busy place with six crew members working and researching 12 hours a day.
There are a lot of obstacles up there, and we had limited time to capture the imagery, so we had to be confident that our approach would work. Oh, and theres that whole zero gravity thing, he wrote.
Floating through the ISS online, youll notice clickable dots with detailed descriptions of the space and its objects to help viewers understand what theyre looking at. Pesquet noted that this is the first time annotations helpful little notes that pop up as you explore the ISS have been added to Street View imagery.
The ISS is a large spacecraft that orbits around Earth at more than 17,500 miles per hour and is home for astronauts from around the world, according to NASA. The ISS is made up of many pieces that were constructed by astronauts beginning in 1998. By 2000, as more pieces of the station were added, the station was ready for people, according to NASA. Portions of the station are connected via modules known as nodes, according to NASA.
The first crew arrived on November 2, 2000, NASA wrote. People have lived on the space station ever since. Over time more pieces have been added. NASA and its partners around the world finished the space station in 2011.
NASA compares the inside of the station to the inside of a house, noting that the structure which weighs almost one million pounds and covers an area the side of a football field has five bedrooms, two bathrooms, a gymnasium and a big bay window.
The station houses labs from the United States, Russia, Japan and Europe.
We can collect data on the Earths oceans, atmosphere, and land surface, Pesquet wrote. We can conduct experiments and studies that we wouldnt be able to do from Earth, like monitoring how the human body reacts to microgravity, solving mysteries of the immune system, studying cyclones to alert populations and governments when a storm is approaching, or monitoring marine litter the rapidly increasing amount waste found in our oceans.
Several times a week, Mission Control at NASAs Johnson Space Center in Houston determines where Earthlings can spot the station from the ground below from thousands of locations all over the globe. To find out the best time to see the station from your town, click here.
Read more:
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Samsung to manufacture iPhone chips for Apple again, report says
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Summer program aims to send students’ coding projects to space – The Mercury News
Posted: at 7:50 am
Fly me to the moon, let me play among the stars, students sang in a large Campbell Middle School classroom as they tucked away their workbooks and laptops.
They werent rehearsing to form a Frank Sinatra tribute band. Crooning the tune is the celestial motivation for a group of roughly a dozen students hoping to get their lines of code to the International Space Station this summer.
The Zero Robotics program at Campbell Middle aims to take students work to the moon and beyond, all while teaching students about space exploration, computer science and coding.
The five-week summer program is an offshoot of a national high school program and competition provided through a partnership between MIT Space Systems Lab, the Innovation learning Center and Aurora Flight Sciences. It is sponsored by NASA, the Center for the Advancement of Science in Space and the Northrup Grumman Foundation.
The program sees students learn about efficient use of fuel and how to write specific lines of code. Once theyve had enough practice on and off the computer, students write and send the best line of code to the competition in their respective state. There are nine other teams in California competing.
Students must complete objectives, such as navigating around obstacles, docking to other satellites or going in a particular direction, all while conserving the most amount of fuel possible.
Winning teams will get their code uploaded to the International Space Station and watch via a live feed as small robots aboard the space station follow their program. The robots are similar to the ones students work with in the program back on Earth.
Students participate in a game to program movements for synchronized, position, hold, engage, reorient, experimental satellites, or SPHERES for short.
I thought the SPHERES would be shaped like the Earth, but they are shaped like a 3D octagon, said sixth-grade student Tamba Bangurah.
This is the first year students from the Campbell Union School District have participated. Summer camp program coordinator Tanner Marcoida said he had been planting the seed among some students toward the end of the school year to generate interest in participating.
If we have the best code out of our region, then our code will be uploaded to the space station and we will get to see the SPHERES, the actual robots that are on the space station in zero gravity, he said. We actually get to see them play out the game that they have been coding this entire time. Thats quite the treat for hard work.
Documenting the middle school students feat is a film crew from National Geographic.
Marcoida and his students have had Thomas Verrettes film crew follow their daily lessons and games and it will stick around until the final winner is announced.
I didnt know what school I would be in at the time, what students Id be following and the educators, Verrette said. I used the orientation as that resource. I watched how all the educators responded to the program and interviewed quite a few of them and then decided on Campbell.
After deciding Marcoida and his students would be an interesting group to film, he showed up the second day of camp with cameras to get the students used to the crew and having cameras in the room.
The kids are great, Verrette said. Every once in awhile theyll smile and laugh because they forget that were there. In some ways they are a lot easier to deal with than adults when youre trying to document something.
Verrette said he hopes when the documentary is complete and released, people have a newfound respect for science.
As for a release date, Verrette said that is to be determined.
For more information about Zero Robotics, visit zerorobotics.mit.edu.
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Key Parkinson’s Protein Gets Starring Research Role on International Space Station – Parkinson’s News Today
Posted: at 7:50 am
When a resupply mission lifts off in August bound for the International Space Station, it will be carrying an important cargo for researchers studying Parkinsons disease: aprotein consideredto be a key to potential future therapies.
Theleucine-rich repeat kinase 2(LRRK2) protein will be the focus of an experiment conducted on the Space Station.It is hoped that the microgravity conditions aboard the Space Station will allow growth of larger, more regular LRRK2 protein crystals, which would help scientists solve the proteins structure providing valuable information for thedesign of optimized therapies to fight Parkinsons disease (PD).
The experiment is the result of a partnership between theMichael J. Fox Foundation for Parkinsons Researchand the Center for the Advancement of Science in Space (CASIS).
Were thrilled that PD research has been selected to travel to the International Space Station and honored to partner with CASIS on behalf of the PD community here on Earth, said Michael J. Fox, the actor who started the foundation after he was diagnosed with Parkinsons, in a video message played at the International Space Station Research and Development Conference held in Washington, DC, July 17 20.
The SpaceX CRS-12 cargo resupply mission scheduled for liftoff in August will carry LRRK2 protein to the Space Station to be used in the Crystallization of LRRK2 Under Microgravity Conditions (CASIS PCG 7) experiment.
In its role as manager of the Space StationsU.S. National Laboratory, CASIS is responsible for coordinating transfer of scientific materials to and from theSpace Station and oversight of work conducted in the laboratory. The Michael J. Fox Foundation, which initiated this project, has supported earthside preparation of the protein for growth in space.
Advancing Understanding of LRRK2 as a Key Parkinsons Drug Target
LRRK2 is considered to be the greatest known genetic contributor to Parkinsons disease, according to the Michael J. Fox Foundation. Most Parkinsons cases are categorized as idiopathic of unknown cause with only about 10 percent of cases having been linked to a genetic cause. LRRK2 gene mutations are the most common cause of Parkinsonsin that minority, which represents only 1 to 2 percent of total Parkinsons cases.
However, LRRK2 mutations account for a much higher proportion of Parkinsonscases among people of certain ethnic groups, notably Ashkenazi Jews, North African Arab Berbers, and Basques, than they doin the general population.
The foundationnotes that while estimates vary, it is believed that mutated LRRK2 (predominantly the mutation scientists refer to as G2019S) account for some 15 to 20 percent of Parkinsons cases among Ashkenazi Jews, and about 40 percent of cases in North African Arab Berbers. Also, other genetic changes in LRRK2 have been found to increase risk of developing Parkinsons among people of other ethnic backgrounds, such as in Asians of Chinese descent.
Because LRRK2 protein function is heightened in people with Parkinsons disease, and is associated with a mutation in the LRRK2 gene, the foundation believes therapies targeting this gene could also accelerate development of treatments that can benefit a broader Parkinsons population.
However, one obstacle holding back this line of drug development is the limited understanding of LRRK2s exact structure. The foundationnotes that greater understanding of a proteins shape and structure can help developers design therapies more likely to engage a particular protein in treatment of disease.
Overcoming Gravitational Limitations
Earths gravitational field allows only low resolution versions of LRRK2 protein to be grown. However, the Crystallization of LRRK2 Under Microgravity Conditions (CASIS PCG 7) experiment will use automated biotechnology devices operating in the microgravity environment to grow larger, better-formed protein crystals with fewer defects that may yield higher resolution views of LRRK2. These will then be returned to Earth for postflight analysis.
Having a better detailed view of the precise shape and morphology of LRRK2s crystalline structure would help scientists better understand Parkinsons pathology, and accelerate development of LRRK2 inhibitor therapies designed to prevent, slow, or stop Parkinsons disease progression.
The unique environment of the International Space Station untethers research from restrictions imposed by gravity,CASIS president and executive director, Gregory H. Johnson, said in a press release. CASIS is glad to partner with The Michael J. Fox Foundation to explore the structure of this important piece of the Parkinsons puzzle.
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SpaceX’s Mars Plans Hit a Pothole. Up Next: the Moon? – WIRED
Posted: at 7:49 am
Elon Musk speaks at the International Space Station Research and Development Conference in Washington, D.C. on July 19, 2017.
Aaron Bernstein/Reuters
Its been less than a year since Elon Musk announced his plans to settle humans on Mars during a talk in Guadalajara, Mexico. On stage at the International Astronautical Congress, the billionaire invoked the lore of Hitchhikers Guide to the Galaxy and Battlestar Galactica while describing a massive passenger ship loaded with the essentialsyou know, like a movie theater and a restaurant. SpaceX hoped to launch these breezy cruises to the red planet in the early 2030s.
Plot twist: Musk's original vision is no longer canon in his universe. On Wednesday, Musk took questions during a keynote discussion at the International Space Station R&D conference in Washington, DC. In between dad jokes about tunnel digging , a staple artificial intelligence threat assessment , and a spirited attempt to unpack the potential for interplanetary war, he candidly revealed a series of obstacles for SpaceX and its plan to build a city on Mars. SpaceX is rebooting its colonization plan, and may pivot to focus on a moon base that would aid that effort.
The Hawthorne, California-based spaceflight company has spent years touting propulsive landing technology for the next version of its Dragon spacecraft. SpaceX expected to equip the Dragon V2, rated for crew and cargo, with four small SuperDraco engines and deployable landing legs to allow for a guided surface touchdownfirst on the Earths surface, and then, maybe, on Mars. SpaceX was confident enough in the design to propose a variant of the vehicle Musk claimed would be able to land anywhere in the solar system.
The pitch for those uncrewed Red Dragon missions to Mars included a collaboration with NASA to gather landing data, test communications, and plan for potential contamination from Earth-based microbes. The space agency, of course, has its own boots-on-Mars ambitions, and hopes to send astronauts to the red planet aboard the Orion spacecraft by 2040. Musk would later compare Red Dragon launches to a train leaving the station, delivering cargo and science to Mars in preparation for a human mission.
But now, SpaceX has pulled the plug on its prologue to an interplanetary future.
Musk explained that Red Dragon was no longer in line with the evolving vision SpaceX has for getting to Marsspecifically, the part where you have to land on Mars . The company is hitting pause on the development of its propulsive landing technology on the Dragon V2 spacecraft. Musk argued that while the technology works, SpaceX would be put through the wringer trying to meet NASAs safety standards for landing a human crew on the ground. It doesnt seem like the right way to apply resources right now, Musk said. Im pretty confident that is not the right way, and that theres a far better approach. He later tweeted that SpaceX would still land with propulsive thrusters on Mars, but with a larger spacecraft.
SpaceX has had a busy year adding to its growing arsenal of recovered rockets while launching more times than any other year since its founding. The company also managed to re-fly both its Falcon 9 rocket and Dragon cargo capsule . In the flurry of praise surrounding rocket landings and Mars concepts, the fact that SpaceX has yet to attempt or complete a deep space mission of any kind still weighs on the companys future. Red Dragon would have been SpaceXs first toe into the deep end of the pool.
Its journey would have begun atop the triple-booster Falcon Heavy rocket, the famously-delayed launch vehicle that Musk claims has over twice the payload capability of a single Falcon 9 rocket, able to easily deliver 100,000 pounds to low-Earth orbit. At the ISS R&D conference, Musk invited the audience and those watching the livestream to witness the launch of the vehiclecurrently projected for this fallfrom Kennedy Space Center. But he followed with an uneasy disclaimer: Real good chance that vehicle doesnt make it to orbit.
That uncertainty doesnt bode well for Musks original Mars ambitions. Musk argued that the Falcon Heavy was impossible to test on the ground due to the machines complexity. And he said that development was far more difficult than SpaceX expected, admitting that the company was naive in its original projections. The simultaneous firing 27 orbital engines notwithstanding, launching a Falcon Heavy includes changing aerodynamics, heightened vibration, and an enormous thrust that pushes qualification levels of the flight hardware to the limit. Musk admitted on Wednesday that limited damage to former Apollo 11 Pad 39A would be a win in the aftermath of the Falcon Heavy test flight. Along with Musk, the audience laughed nervously.
According to Musks keynote this week, SpaceX is planning to scale down its Mars-bound spacecraft to a size suitable for a wider range of missionsmissions that would help pay for its development costs. A size reduction would certainly have a large economic impact on manufacturing, but savings could be augmented by focusing all efforts on a single reusable vehicle that could serve both low-Earth orbit and deep space. And Musk also offered that building a base on the moon is essential to getting the public excited about space again and would be an excellent stepping stone toward Mars.
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But is that a suggestion to another company? To NASA? Or is SpaceX going to unveil plans for a moon base as part of their updated Mars architecture?
Elon Musk has said that he would offer priority seating to NASA for missions to lunar orbit. SpaceX was the first private company to dock with the space station and the success between the federal space agency and the spaceflight company could point to a continuing partnership that expands beyond low Earth orbit. The ISS wont be around forever, and with NASA shifting toward deep space exploration, the opportunity to give the agency a lift is there. Especially if NASA wants to return to the moon.
But that doesnt mean SpaceX is abandoning its Mars ambitions; far from it. SpaceX owes much of its financial and development success to its partnership with NASA, and theres no doubt Musk will pursue that partnership beyond low-Earth orbit. That means that NASA astronauts could one day be flying on these deep space missions under lucrative taxpayer-funded contracts. Before then, SpaceX will have to fully prove its technology, along with life support systems and radiation protection for crewed missions.
Just a week ago, Musk dispatched SpaceX VP Tim Hughes to make the case for deep space in front of the Senate Subcommittee on Space, Science & Technology. Hughes used the success of SpaceX and NASAs commercial resupply missions and the governing Commercial Orbital Transportation Services program to make a case for partnership in deep space exploration. "To this day, Americas achievement of landing men on the moon and returning them safely to Earth likely represents humankinds greatest and most inspirational technological achievement, he said. Now, other nations like China seek to replicate an achievement America first accomplished 48 years ago. Maybe SpaceX can add private companies to the roster.
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C9ORF72 Throws a Wrench into DNA Repair Machinery | ALZFORUM – Alzforum
Posted: at 7:48 am
21 Jul 2017
Hexanucleotide expansions in the C9ORF72 genethe most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementiamount a multipronged attack on the DNA repair system, according to a July 17 study in Nature Neuroscience. Researchers led by Mimoun Azzouz and Sherif El-Khamisy at the University of Sheffield in England reported that the repeat expansions trigger the formation of DNA-RNA hybrids, called R-loops, that break DNA. At the same time, the unusual dipeptide repeats (DPRs) translated from these expansions derail efforts to mend the damage. The researchers found evidence of broken DNA and a subpar repair response in mice expressing the expansions, and also in postmortem tissue from C9-ALS patients. They proposed that the onslaught of DNA damage in neurons ultimately leads to their demise, and that targeting the pathway could become a therapeuticstrategy.
DNA damage is a common hazard inside cells, and an extensive repair system exists to lessen its toll. Neurons are acutely dependent on this repair machinery, as they cannot easily wipe the slate clean through replication (see Pan et al., 2014).Making matters worse, oxidative DNA damage increases in the brain, and repair mechanisms start to falter with age and in the context of neurodegenerative disease (Sep 2011 news; Feb 2013 conference news).
Against this backdrop, El-Khamisy and colleagues wondered if an additional stressorC9ORF72 hexanucleotide expansionsmight add fuel to the fire. These expansions of the GGGGCC sequence exist in hundreds to thousands of copies in people with ALS/FTD. Both RNA foci formed from their transcription, and the DPRs generated by their translation, reportedly inflict damage on neurons. The researchers hypothesized that due to the expansions repetitive nature, and the abundance of GC repeats within them, the C9ORF72 expansions could be extremely prone to folding into R-loops, a type of DNA-RNA hybrid structure that can form during transcription (Aguilera and Garcia-Muse, 2012). R-loops are known triggers of double-stranded DNA breaks (Hamperl and Cimprich, 2014).
To learn if the expansions caused R-loops, first author Callum Walker and colleagues transfected the expansions into human fetal lung fibroblasts. Then they probed with antibodies specific to R-loops and phosphorylated histone H2AX, an established indicator of double-stranded breakages. Indeed, they found that cells expressing 102 repeats that could not be translatedand thus only formed RNA foci, not DPRsharbored elevated numbers of R-loops and breaks. This was also the case in cells transfected with constructs that did result in the translation of 34 or 69 DPRs. Notably, overexpression of senataxin, an RNA helicase known to resolve R-loops, reduced the number of breakages and even normalized the uptick in cell death the breakages triggered. Together, the findings suggested that the repeat expansions caused R-loops, which snapped DNA and harmedcells.
Cells transfected with dipeptide repeats (green) build up R-loops (red) in their DNA. [Courtesy of Walker et al., Nature Neuroscience2017.]
The researchers further wondered whether the repeat expansions would affect DNA repair. In both human fibroblasts and primary rat cortical neurons expressing the expansions, the researchers found the repair machinery to be profoundly hobbled. For starters, ataxia telangiectasia (ATM), the master DNA repair kinase, was hypophosphorylated and failed to activate when the researchers treated cells with DNA-damaging toxins. This led to a dismal nuclear recruitment of 53BP1, a factor that rejoins broken DNA, as well as subpar phosphorylation of another key ATM target,p53.
Through an extensive battery of biochemical and immunostaining experiments, the researchers zeroed in on the mechanisms that derailed the DNA repair machinery. The E3 ubiquitin ligase RN168 normally ubiquitylates histone H2A, an adornment that is needed to recruit 53BP1 to damaged DNA. However, in cells expressing the expansions, the researchers found RN168 tied up in p62 inclusions instead. This led to a reduction in ubiquitylated H2A and stymied 53BP1 recruitment. Interestingly, previous studies have reported that successful recruitment of 53BP1 to DNA helps sustain further ATM signaling (Lee et al., 2010). Therefore, RN168s entrapment in p62 inclusions could potentially derail the entire DNA repair process. In support of this idea, overexpression of RN168, or depletion of p62, restored 53BP1 recruitment and reduced the number of DNA breaks in cells expressing the repeatexpansions.
Strikingly, the researchers also observed R-loops, double-stranded breaks, and signs of weak ATM signaling in neurons from mice injected with viral vectors harboring the repeat expansions. These animals suffered a 20 percent loss in brainstem neurons, as well as motor deficits. The researchers proposed that DNA damage was the primary cause of this neurodegeneration, a hypothesis they will test by overexpressing senataxin and/or RN168 in the animals, El-Khamisy toldAlzforum.
The researchers also found evidence of DNA in disrepair in postmortem spinal cord tissue from ALS patients, which were wrought with R-loops, double-stranded DNA breaks, and signs of ATM signalingdefects.
Repeat Assault. In the proposed model, C9ORF72 repeat expansions damage DNA and thwart its repair. [Courtesy of Walker et al., Nature Neuroscience2017.]
The researchers proposed that C9ORF72 hexanucleotide expansions attacked DNA via two distinct, yet intertwined, pathways: through directly causing damage via R-loops, and by dismantling ATM-mediated DNA repair. El-Khamisy proposed that the repeat-laden RNA causes R-loops, while the DPRs manifest the p62 inclusions that sequester RN168 and disrupt repair. Interestingly, the latter pathway meshes with other recent findings implicating RN168 sequestration in p62 inclusions in the disruption of DNA repair (Wang et al., 2016).
Walkers findings dovetail with a previous study led by Li-Huei Tsai of MIT, which reported that the ALS gene FUS is recruited to DNA breaks and helps orchestrate repair (Sep 2013 news). The findings of the current paper are very consistent with ours, and together make a strong argument for the role of unrepaired DNA breaks in ALS, Tsaicommented.
This paper is particularly well done, commented Ray Truant of McMaster University in Hamilton, Canada. It really establishes ATM-mediated DNA repair as a common node in neurodegenerative disease, hesaid.
Truant recently reported that mutated huntingtin protein disrupted DNA repair (Maiuri et al., 2017). He added that as reactive oxidation builds in the brain with age, the efficiency of the DNA repair response could strongly influence the onset of neurodegenerative disease, a hypothesis supported by recent genome wide association studies (Bettencourt et al., 2016;Jones et al., 2017).
The study also provides researchers with a number of therapeutic targets, some of which may prove useful across neurodegenerative diseases, Truant added.JessicaShugart
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C9ORF72 Throws a Wrench into DNA Repair Machinery | ALZFORUM - Alzforum
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Police: DNA links Decatur man to April burglary – The Decatur Daily
Posted: at 7:48 am
A Decatur man was arrested Thursday after DNA collected from the scene of a burglary matched his DNA in the CODIS criminal DNA database, Decatur police said.
Eric Deondre Warner, 35, of 416 10th Ave. N.W., was charged Thursday with third-degree burglary, police said.
On Monday, DNA collected from the scene of the burglary matched with his DNA, which was on file in the CODIS database, police said.
On April 19, a burglary in the 400 block of Finley Drive N.W. was reported to police, reports show. The victim said items were taken from the home and it was "completely ransacked," according to reports.
Investigators were able to collect DNA evidence from the scene, which ultimately led to Warner being developed as a suspect, police said.
Warrants for Warner's arrest were obtained Thursday and were served on him in the Morgan County Jail, where he was incarcerated for other charges, police said.
Bail for his new burglary charge was set at $2,500.
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Who Killed Robin Brooks? DNA Technology Helps Paint Portrait of Killer – FOX40
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ROSEMONT -- Cold case investigators said Robin Brooks was raped and stabbed to death inside her apartment in the Rosemont area of Sacramento County more than 37 years ago.
Detectives have a full DNA profile of the suspected killer from his blood, but the case is still unsolved after all these years. But now, new technology is giving detectives a different way to look at the DNA and a glimpse at what the killer could possibly look like.
Its called DNA phenotyping. It sounds like science fiction, but this forensic method uses an unknown suspects DNA to create a composite sketch of the mystery persons physical characteristics.
Its not intended to be a photo ID, said Dr. Ellen Greytak over the phone to FOX40. Its a genetic witness in the absence of an eye witness.
Doctor Greytak works for Parabon NanoLabs, a Reston, Virginia-based biotech company that offers the tool called Snapshot. The Sacramento County Sheriffs Department has contracted the company to come up with two profiles of the suspected killer in Brooks unsolved murder case.
We have DNA, we have the person who did this, said retired Sacramento County sheriffs Detective Micki Links. There's no doubt about who it is. We just need their name.
The DNA profile of the suspected killer in Brooks case was put into all the criminal databases in 2004, but a match has never been made.
Links said she believes these two profiles will aid in the investigation by giving fading memories a look back at what the killers face may have looked like when he was 25. Another profile has the suspect aged to 56.
Links also shared new details on Robins whereabouts before her death.
For decades, investigators thought Brooks finished her shift at Donut Time off Keifer Boulevard and walked straight home to her apartment on Tallyho Drive. That apartment has been renamed the Garden Club Apartments.
But detectives said an informant, who has been cleared as a suspect, has come forward with a different timeline. He told them he saw Brooks at a house party somewhere off Roseport Way. The unnamed informant also told investigators Brooks went to the party after work and then went home.
The informant added that the party was made up of mostly teens, between 15 and 19 years old, many from Hiram Johnson High School and the nearby Lincoln Village.
You're not going to get away with this, said Links. I'm going to do whatever I can to find you, and make you pay for what you did.
Robins family is also still fighting for answers. Maria Arrick, Robins older sister, is offering up to a $10,000 reward for information that leads to the arrest of Brooks killer.
If you have any information regarding this case, please contact the Sacramento County Sheriffs Department main homicide line at (916) 874-5057. Or you can go to a special website set up for the victims of unsolved homicides in Sacramento County.
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Removal of Aging Cells to Increase Longevity – Anti Aging News
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1167 1 Posted on Jul 21, 2017, 8 a.m.
Researchers find that a targeted removal of senescent cells could delay the onset of age-relateddegenerative joint conditions,such as osteoarthritis.
An international team of professional researchers joined forces to conduct a study that confirmed the targeted removal of senescent cells that collect in vertebrate tissue across the aging process contributes to delaying the onset of pathologies related to aging. The research was led by the Johns Hopkins University School of Medicine researcher Dr. Chaekyu Kim. He worked in tandem with the Johns Hopkins University School of Medicine's Dr. Ok Hee Jeon. Additional contributors from the University of California, Berkeley, the Mayo Clinic College of Medicine, the University Medical Center Groningen and the Buck Institute for Research on Aging and Unity Biotechnology, Inc. also played a part in the research. The findings were published this past April in the journal Nature Medicine.
About the Study
The research team presented a new pharmacologic candidate for the alleviation of degenerative joint conditions like osteoarthritis (OA) that are age-related. This occurs through the selective destroying of senescent cells known as SnCs. Such cells gather throughout the aging process in the body's vertebrate tissues. They are located at areas where age-related pathology occurs. Though such cells play an important role in the healing of wounds and repairing injured body sites, they might also lead to the onset of cancer within tissues. As an example, in particular joints like the knees and other cartilage tissues, SnCs are not always cleared from the area following the injury. This leads to the continuation of OA development.
In order to test the notion that SnCs might play a role in OA development, the researchers cut the anterior cruciate ligaments in young and old mice to a mimic a similar injury in human beings. The researchers applied injections of the experimental drug known as UBX0101 to remove SnCs following the anterior cruciate ligament transection surgery.
Preclinical studies in human and mice cells suggest removing SnCs dramatically decreases the development of post-traumatic OA as well as related pain. Removing SnCs also creates a prochondrogenic environment that allows for the growth of new cartilage and joint repair
The Findings
The findings suggest the selective removal of aged cells from the body's joints might decrease the development of post-traumatic OA. This selective removal might also allow for the growth of new cartilage and the repairing of joints. Aged mice did not show signs of any cartilage regeneration following the treatment applied through UBX0101 injections. The findings are relevant to human disease through validation with the use of chondrocytes isolated from patients who suffer from arthritis. The findings offer important insights into therapies keying in on the use of SnCs to treat trauma as well as degenerative joint disease related to the aging process.
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Removal of Aging Cells to Increase Longevity - Anti Aging News
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